related to degree

• Lo, Julian Castro, Ph.D. in Chemistry, Scripps Research 2012 - 2017

authors

• Lo, Julian Castro
• Gui, J.
• Yabe, Y.
• Pan, C. M.
• Baran, Phil

publication date

• 2014

journal

• Nature  Journal

abstract

• Carbon-carbon (C-C) bonds form the backbone of many important molecules, including polymers, dyes and pharmaceutical agents. The development of new methods to create these essential connections in a rapid and practical fashion has been the focus of numerous organic chemists. This endeavour relies heavily on the ability to form C-C bonds in the presence of sensitive functional groups and congested structural environments. Here we report a chemical transformation that allows the facile construction of highly substituted and uniquely functionalized C-C bonds. Using a simple iron catalyst, an inexpensive silane and a benign solvent under ambient atmosphere, heteroatom-substituted olefins are easily reacted with electron-deficient olefins to create molecular architectures that were previously difficult or impossible to access. More than 60 examples are presented with a wide array of substrates, demonstrating the chemoselectivity and mildness of this simple reaction.

subject areas

• Alkenes
• Carbon
• Chemistry Techniques, Synthetic

PubMed Central ID

• PMC4271735

International Standard Serial Number (ISSN)

• 0028-0836

Digital Object Identifier (DOI)

• 10.1038/nature14006

PubMed ID

• 25519131

start page

• 343

end page

• 348

volume

• 516

issue

• 7531