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Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase

Academic Article
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Overview

authors

  • Liverton, N. J.
  • Butcher, J. W.
  • Claiborne, Christopher Fairman
  • Claremon, D. A.
  • Libby, B. E.
  • Nguyen, K. T.
  • Pitzenberger, S. M.
  • Selnick, H. G.
  • Smith, G. R.
  • Tebben, A.
  • Vacca, J. P.
  • Varga, S. L.
  • Agarwal, L.
  • Dancheck, K.
  • Forsyth, A. J.
  • Fletcher, D. S.
  • Frantz, B.
  • Hanlon, W. A.
  • Harper, C. F.
  • Hofsess, S. J.
  • Kostura, M.
  • Lin, J.
  • Luell, S.
  • O'Neill, E. A.
  • Orevillo, C. J.
  • Pang, M.
  • Parsons, J.
  • Rolando, A.
  • Sahly, Y.
  • Visco, D. M.
  • O'Keefe, S. J.

publication date

  • June 1999

journal

  • Journal of Medicinal Chemistry  Journal

subject areas

  • Administration, Oral
  • Aminopyridines
  • Animals
  • Arthritis, Experimental
  • Biological Availability
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Drug Design
  • Enzyme Inhibitors
  • Female
  • Humans
  • Imidazoles
  • Macaca mulatta
  • Mice
  • Mitogen-Activated Protein Kinases
  • Rats
  • Stimulation, Chemical
  • Structure-Activity Relationship
  • Tumor Necrosis Factor-alpha
  • p38 Mitogen-Activated Protein Kinases
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Identity

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/jm9805236

PubMed ID

  • 10377223
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Additional Document Info

start page

  • 2180

end page

  • 2190

volume

  • 42

issue

  • 12

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