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Abnormal expression of plasminogen activator inhibitors in patients with gestational trophoblastic disease

Academic Article
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Overview

authors

  • Estelles, A.
  • Grancha, S.
  • Gilabert, J.
  • Thinnes, T.
  • Chirivella, M.
  • Espana, F.
  • Aznar, J.
  • Loskutoff, David J.

publication date

  • October 1996

journal

  • American Journal of Pathology  Journal

abstract

  • We previously reported significantly elevated levels of plasminogen activator inhibitor type 1 (PAI-1) in plasma and placenta from pregnant women with severe pre-eclampsia, and pre-eclampsia is a frequent problem in molar pregnancies. As increases in PAI-1 may contribute to the placental alterations that occur in pre-eclampsia, we have begun to investigate changes in PAI-1 as well as PAI-2 and several other components of the fibrinolytic system in patients with trophoblastic disease. Significant increases in plasma PAI-1 and decreases in plasma PAI-2 levels were observed in molar pregnancies when compared with the levels in normal pregnant women of similar gestational age. PAI-1 antigen levels also were increased, and PAI-2 levels were decreased in placenta from women with molar pregnancies compared with placenta obtained by spontaneous abortion. Immunohistochemical analysis revealed strong positive and specific staining of PAI-1 in trophoblastic epithelium in molar pregnancies and relatively weak staining of PAI-2. No association between the distribution of PAI-1 and vitronectin was found, and no specific signal for tissue type PA, urokinase type PA, tumor necrosis factor-alpha, or interleukin-1 was detected. In situ hybridization revealed an increase in PAI-1 but not PAI-2 mRNAs in placenta from molar pregnancies in comparison with placenta from abortions. These results demonstrate increased PAI-1 protein and mRNA in trophoblastic disease and suggest that localized elevated levels of PAI-1 may contribute to the hemostatic problems associated with this disorder.

subject areas

  • Female
  • Humans
  • Hydatidiform Mole
  • Placenta
  • Plasminogen Activator Inhibitor 1
  • Plasminogen Activator Inhibitor 2
  • Plasminogen Inactivators
  • Pregnancy
  • Tissue Polypeptide Antigen
  • Uterine Neoplasms
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Identity

PubMed Central ID

  • PMC1865200

International Standard Serial Number (ISSN)

  • 0002-9440

PubMed ID

  • 8863672
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Additional Document Info

start page

  • 1229

end page

  • 1239

volume

  • 149

issue

  • 4

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