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Zhou, Jiacheng

Graduate Student

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Positions

• 2005 - Executive Director, Incyte

Websites

• Doctoral Dissertation

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Publications

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• academic article

  • Priestley, E. S., De Lucca, I., Zhou, J. L., Zhou, J., Saiah, E., Stanton, R., Robinson, L., Luettgen, J. M., Wei, A., Wen, X., Knabb, R. M., Wong, P. C., et al. Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor Bioorganic & Medicinal Chemistry Letters  2013 23:2432-2435  DOI:10.1016/j.bmcl.2013.02.013
  • Xue, C. B., Chen, L., Cao, G., Zhang, K., Wang, A., Meloni, D., Glenn, J., Anand, R., Xia, M., Kong, L., Huang, T., Feng, H., et al. Discovery of INCB9471, a potent, selective, and orally bioavailable CCR5 antagonist with potent anti-HIV-1 activity ACS Medicinal Chemistry Letters  2010 1:483-487  DOI:10.1021/ml1001536  PMID:24900235  PMCID:PMC4007949
  • Lin, Q., Meloni, D., Pan, Y., Xia, M., Rodgers, J., Shepard, S., Li, M., Galya, L., Metcalf, B., Yue, T. Y., Liu, P., Zhou, J. Enantioselective synthesis of Janus kinase inhibitor INCB018424 via an organocatalytic aza-Michael reaction Organic Letters  2009 11:1999-2002  DOI:10.1021/ol900350k  PMID:19385672
  • Zhou, J., Bhattacharjee, A., Chen, S., Chen, Y., Duffy, E., Farmer, J., Goldberg, J., Hanselmann, R., Ippolito, J. A., Lou, R., Orbin, A., Oyelere, A., et al. Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics Bioorganic & Medicinal Chemistry Letters  2008 18:6175-6178  DOI:10.1016/j.bmcl.2008.10.011  PMID:18947996
  • Zhou, J., Bhattacharjee, A., Chen, S., Chen, Y., Duffy, E., Farmer, J., Goldberg, J., Hanselmann, R., Ippolito, J. A., Lou, R., Orbin, A., Oyelere, A., et al. Design at the atomic level: generation of novel hybrid biaryloxazolidinones as promising new antibiotics Bioorganic & Medicinal Chemistry Letters  2008 18:6179-6183  DOI:10.1016/j.bmcl.2008.10.014  PMID:18951792
  • Hanselmann, R., Zhou, J., Ma, P., Confalone, P. N. Synthesis of cyclic and acyclic β-amino acids via chelation-controlled 1,3-dipolar cycloaddition Journal of Organic Chemistry  2003 68:8739-8741  DOI:10.1021/jo034940o  PMID:14575516
  • Boger, D. L.*, Zhou, J. C.*, Borzilleri, R. M., Nukui, S., Castle, S. L. Synthesis of (9R,12S)- and (9S,12S)-cycloisodityrosine and their N-methyl derivatives Journal of Organic Chemistry  1997 62:2054-2069  DOI:10.1021/jo961346o  PMID:11671510 (* = equal contribution)
  • Boger, D. L.*, Zhou, J. C.* Key analogues of the tetrapeptide subunit of RA-VII and deoxybouvardin Bioorganic & Medicinal Chemistry  1996 4:1597-1603  DOI:10.1016/0968-0896(96)00151-4  PMID:8931929 (* = equal contribution)
  • Boger, D. L.*, Zhou, J. C.* Alternative synthesis of the cycloisodityrosine subunit of deoxybouvardin, RA-VII, and related agents: reassignment of the stereochemistry of prior intermediates Journal of Organic Chemistry  1996 61:3938-3939  DOI:10.1021/jo9604144  PMID:11667262 (* = equal contribution)
  • Boger, D. L.*, Zhou, J. C.*, Cai, H. Demonstration and definition of the noncovalent binding selectivity of agents related to CC-1065 by an affinity cleavage agent: Noncovalent binding coincidental with alkylation Bioorganic & Medicinal Chemistry  1996 4:859-867  DOI:10.1016/0968-0896(96)00073-9  PMID:8818235 (* = equal contribution)
  • Boger, D. L.*, Zhou, J. C.*, Borzilleri, R. M., Nukui, S. Synthesis of (9S,12S)-cycloisodityrosine and its unnatural (9R,12S)-diastereomer Bioorganic & Medicinal Chemistry Letters  1996 6:1089-1092  DOI:10.1016/0960-894x(96)00179-5 (* = equal contribution)
  • Boger, D. L.*, Zhou, J. C.*, Winter, B., Kitos, P. A. Key analogs of the tetrapeptide subunit of RA-VII and deoxybouvardin Bioorganic & Medicinal Chemistry  1995 3:1579-1593  DOI:10.1016/0968-0896(95)00141-7  PMID:8770383 (* = equal contribution)
  • Boger, D. L., Colletti, S. L., Teramoto, S., Ramsey, T. M., Zhou, J. C. Synthesis of key analogs of bleomycin A(2) that permit a systematic evaluation of the linker region - identification of an exceptionally prominent role for the L-threonine substituent Bioorganic & Medicinal Chemistry  1995 3:1281-1295  DOI:10.1016/0968-0896(95)00113-u  PMID:8564421
  • Boger, D. L., Teramoto, S., Zhou, J. C. Key synthetic analogs of bleomycin A(2) that directly address the effect and role of the disaccharide - demannosylbleomycin A(2) and alpha-D-mannopyranosyldeglycobleomycin A(2) Journal of the American Chemical Society  1995 117:7344-7356  DOI:10.1021/ja00133a008
  • Boger, D. L.*, Zhou, J. C.* N-desmethyl derivatives of deoxybouvardin and RA-VII: synthesis and evaluation Journal of the American Chemical Society  1995 117:7364-7378  DOI:10.1021/ja00133a010 (* = equal contribution)
  • Boger, D. L., Patane, M. A., Zhou, J. C. Solution-phase conformational studies of the cyclic peptide RA-VII: lithium-chloride perturbation of the conformational equilibria Journal of the American Chemical Society  1995 117:7357-7363  DOI:10.1021/ja00133a009
  • Boger, D. L., Teramoto, S., Honda, T., Zhou, J. C. Synthesis and evaluation of the fully functionalized bleomycin A(2) metal-binding domain-containing the 2-O-(3-O-carbamoyl-alpha-D-mannopyranosyl)-alpha-L-gulopyranosyl disaccharide Journal of the American Chemical Society  1995 117:7338-7343  DOI:10.1021/ja00133a007
  • Boger, D. L., Patane, M. A., Zhou, J. C. Total synthesis of bouvardin, O-methylbouvardin, and O-methyl-N-9-desmethylbouvardin Journal of the American Chemical Society  1994 116:8544-8556  DOI:10.1021/ja00098a015
  • Boger, D. L.*, Zhou, J. C.* Total synthesis of (+)-piperazinomycin Journal of the American Chemical Society  1993 115:11426-11433  DOI:10.1021/ja00077a047 (* = equal contribution)
  • Boger, D. L.*, Zhou, J. C.* CDPI3-enediyne and CDPI3-EDTA conjugates - a new class of DNA cleaving agents Journal of Organic Chemistry  1993 58:3018-3024  DOI:10.1021/jo00063a019 (* = equal contribution)
  • Boger, D. L., Yohannes, D., Zhou, J. C., Patane, M. A. Total synthesis of cycloisodityrosine, RA-VII, deoxybouvardin, and N29-desmethyl-RA-VII - identification of the pharmacophore and reversal of the subunit functional roles Journal of the American Chemical Society  1993 115:3420-3430  DOI:10.1021/ja00062a004

Background

education and training

• Ph.D. in Chemistry, Scripps Research 1991 - 1996
• M.S. in Medicinal Chemistry, China Pharmaceutical University 1984 - 1987
• B.S. in Organic Chemistry, Nanjing University 1978 - 1982

advisee of

• graduate advising relationship

  • Boger, Dale, Ph.D.  candidacy, 1992 - 1996

Contact

full name

• Jiacheng Zhou

geographic location

• Scripps California