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Wolfe, Amanda
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Wolfe, Amanda

Graduate Student
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Positions

  • 2013 - Faculty Member, University of North Carolina Asheville (UNCA)

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  • Doctoral Dissertation
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Publications

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  • academic article

    • Murray, E. M., Allen, C. F., Handy, T. E., Huffine, C. A., Craig, W. R., Seaton, S. C., Wolfe, A. L. Development of a robust and quantitative high-throughput screening method for antibiotic production in bacterial libraries ACS Omega  2019 4:15414-15420  DOI:10.1021/acsomega.9b01461  PMID:31572841  PMCID:PMC6761686
    • Bouthillette, L. M., Darcey, C. A., Handy, T. E., Seaton, S. C., Wolfe, A. L. Isolation of the antibiotic pseudopyronine B and SAR evaluation of C3/C6 alkyl analogs Bioorganic & Medicinal Chemistry Letters  2017 27:2762-2765  DOI:10.1016/j.bmcl.2017.04.067  PMID:28478925
    • degree-related publication Wolfe, A. L., Duncan, K. K., Lajiness, J. P., Zhu, K. C., Duerfeldt, A. S., Boger, D. L. A fundamental relationship between hydrophobic properties and biological activity for the duocarmycin class of DNA-alkylating antitumor drugs: hydrophobic-binding-driven bonding Journal of Medicinal Chemistry  2013 56:6845-6857  DOI:10.1021/jm400665c  PMID:23944748  PMCID:PMC3793852
    • degree-related publication Vielhauer, G. A., Swink, M., Parelkar, N. K., Lajiness, J. P., Wolfe, A. L., Boger, D. Evaluation of a reductively activated duocarmycin prodrug against murine and human solid cancers Cancer Biology & Therapy  2013 14:527-536  DOI:10.4161/cbt.24348  PMID:23760495  PMCID:PMC3813569
    • degree-related publication Wolfe, A. L., Duncan, K. K., Parelkar, N. K., Brown, D., Vielhauer, G. A., Boger, D. L. Efficacious cyclic N-acyl O-amino phenol duocarmycin prodrugs Journal of Medicinal Chemistry  2013 56:4104-4115  DOI:10.1021/jm400413r  PMID:23627265  PMCID:PMC3687800
    • degree-related publication Xie, J., Wolfe, A. L., Boger, D. L. Total synthesis of kopsinine Organic Letters  2013 15:868-870  DOI:10.1021/ol303573f  PMID:23391149  PMCID:PMC3578506
    • degree-related publication Wolfe, A. L., Duncan, K. K., Parelkar, N. K., Weir, S. J., Vielhauer, G. A., Boger, D. L. A novel, unusually efficacious duocarmycin carbamate prodrug that releases no residual byproduct Journal of Medicinal Chemistry  2012 55:5878-5886  DOI:10.1021/jm300330b  PMID:22650244  PMCID:PMC3386426
    • Mammana, A., Asakawa, T., Bitsch-Jensen, K., Wolfe, A., Chaturantabut, S., Otani, Y., Li, X., Li, Z., Nakanishi, K., Balaz, M., Ellestad, G. A., Berova, N. Synthesis and characterization of water-soluble free-base, zinc and copper porphyrin-oligonucleotide conjugates Bioorganic & Medicinal Chemistry  2008 16:6544-6551  DOI:10.1016/j.bmc.2008.05.041  PMID:18524599
    • Ballard, T. E., Richards, J. J., Wolfe, A. L., Melander, C. Synthesis and antibiofilm activity of a second-generation reverse-amide oroidin library: a structure-activity relationship study Chemistry-a European Journal  2008 14:10745-10761  DOI:10.1002/chem.200801419  PMID:18942682
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Background

education and training

  • Ph.D. in Chemistry, Scripps Research 2008 - 2013
  • B.S. in Chemistry, North Carolina State University 2004 - 2008

advisee of

  • graduate advising relationship

    • Boger, Dale, Ph.D.  candidacy, 2009 - 2013
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Contact

full name

  • Amanda Lynn Wolfe

geographic location

  • Scripps California 

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