recent publications
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academic article
- Murray, E. M., Allen, C. F., Handy, T. E., Huffine, C. A., Craig, W. R., Seaton, S. C., Wolfe, A. L. Development of a robust and quantitative high-throughput screening method for antibiotic production in bacterial libraries ACS Omega 2019 4:15414-15420 DOI:10.1021/acsomega.9b01461 PMID:31572841 PMCID:PMC6761686
- Bouthillette, L. M., Darcey, C. A., Handy, T. E., Seaton, S. C., Wolfe, A. L. Isolation of the antibiotic pseudopyronine B and SAR evaluation of C3/C6 alkyl analogs Bioorganic & Medicinal Chemistry Letters 2017 27:2762-2765 DOI:10.1016/j.bmcl.2017.04.067 PMID:28478925
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Wolfe, A. L., Duncan, K. K., Lajiness, J. P., Zhu, K. C., Duerfeldt, A. S., Boger, D. L.
A fundamental relationship between hydrophobic properties and biological activity for the duocarmycin class of DNA-alkylating antitumor drugs: hydrophobic-binding-driven bonding
Journal of Medicinal Chemistry
2013
56:6845-6857
DOI:10.1021/jm400665c
PMID:23944748
PMCID:PMC3793852
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Vielhauer, G. A., Swink, M., Parelkar, N. K., Lajiness, J. P., Wolfe, A. L., Boger, D.
Evaluation of a reductively activated duocarmycin prodrug against murine and human solid cancers
Cancer Biology & Therapy
2013
14:527-536
DOI:10.4161/cbt.24348
PMID:23760495
PMCID:PMC3813569
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Wolfe, A. L., Duncan, K. K., Parelkar, N. K., Brown, D., Vielhauer, G. A., Boger, D. L.
Efficacious cyclic N-acyl O-amino phenol duocarmycin prodrugs
Journal of Medicinal Chemistry
2013
56:4104-4115
DOI:10.1021/jm400413r
PMID:23627265
PMCID:PMC3687800
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Xie, J., Wolfe, A. L., Boger, D. L.
Total synthesis of kopsinine
Organic Letters
2013
15:868-870
DOI:10.1021/ol303573f
PMID:23391149
PMCID:PMC3578506
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Wolfe, A. L., Duncan, K. K., Parelkar, N. K., Weir, S. J., Vielhauer, G. A., Boger, D. L.
A novel, unusually efficacious duocarmycin carbamate prodrug that releases no residual byproduct
Journal of Medicinal Chemistry
2012
55:5878-5886
DOI:10.1021/jm300330b
PMID:22650244
PMCID:PMC3386426
- Mammana, A., Asakawa, T., Bitsch-Jensen, K., Wolfe, A., Chaturantabut, S., Otani, Y., Li, X., Li, Z., Nakanishi, K., Balaz, M., Ellestad, G. A., Berova, N. Synthesis and characterization of water-soluble free-base, zinc and copper porphyrin-oligonucleotide conjugates Bioorganic & Medicinal Chemistry 2008 16:6544-6551 DOI:10.1016/j.bmc.2008.05.041 PMID:18524599
- Ballard, T. E., Richards, J. J., Wolfe, A. L., Melander, C. Synthesis and antibiofilm activity of a second-generation reverse-amide oroidin library: a structure-activity relationship study Chemistry-a European Journal 2008 14:10745-10761 DOI:10.1002/chem.200801419 PMID:18942682