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Wineinger, Nathan
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Wineinger, Nathan

Faculty Member
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Positions

  • 2018 - Assistant Professor, Integrative Structural and Computational Biology (ISCB) , Scripps Research
  • 2014 - Director, Biostatistics, , Translational Institute , Scripps Research

Contact

  • nwineing@scripps.edu

Websites

  • Nathan Wineinger, Ph.D.
  • STSI
  • Twitter @NathanWineinger
  • Publications
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Publications

recent publications
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  • Publications without PubMed PMIDs

  • academic article

    • Jaiswal, S. J., Kang, D. Y., Wineinger, N. E., Owens, R. L. Objectively measured sleep fragmentation is associated with incident delirium in older hospitalized patients: Analysis of data collected from an randomized controlled trial Journal of Sleep Research  2020  DOI:10.1111/jsr.13205  PMID:33051948
    • Giraldez, S., Tamayo, P., Wineinger, N., Kim, W., Reed, S. I. Cyclin E overexpression in human mammary epithelial cells promotes epithelial cancer-specific copy number alterations iScience  2019 19:850-859  DOI:10.1016/j.isci.2019.08.043  PMID:31513970  PMCID:PMC6739637
    • Wineinger, N. E., Barrett, P. M., Zhang, Y., Irfanullah, I., Muse, E. D., Steinhubl, S. R., Topol, E. J. Identification of paroxysmal atrial fibrillation subtypes in over 13,000 individuals Heart Rhythm  2019 16:26-30  DOI:10.1016/j.hrthm.2018.08.012  PMID:30118885
    • Klimentidis, Y. C., Raichlen, D. A., Bea, J., Garcia, D. O., Wineinger, N. E., Mandarino, L. J., Alexander, G. E., Chen, Z., Going, S. B. In response to: 'Information bias in measures of self-reported physical activity' International Journal of Obesity  2018 42:2064-2065  DOI:10.1038/s41366-018-0251-6  PMID:30464230
    • Jaiswal, S. J., McCarthy, T. J., Wineinger, N. E., Kang, D. Y., Song, J., Garcia, S., van Niekerk, C. J., Lu, C. Y., Loeks, M., Owens, R. L. Melatonin and sleep in preventing hospitalized delirium: a randomized clinical trial American Journal of Medicine  2018 131:1110-1117  DOI:10.1016/j.amjmed.2018.04.009  PMID:29729237  PMCID:PMC6163056
    • Torkamani, A., Wineinger, N. E., Topol, E. J. The personal and clinical utility of polygenic risk scores Nature Reviews Genetics  2018 19:581-590  DOI:10.1038/s41576-018-0018-x  PMID:29789686
    • Klimentidis, Y. C., Raichlen, D. A., Bea, J., Garcia, D. O., Wineinger, N. E., Mandarino, L. J., Alexander, G. E., Chen, Z., Going, S. B. Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE International Journal of Obesity  2018 42:1161-1176  DOI:10.1038/s41366-018-0120-3  PMID:29899525
    • Kim, K. I., Nikzad, N., Quer, G., Wineinger, N. E., Vegreville, M., Normand, A., Schmidt, N., Topol, E. J., Steinhubl, S. Real world home blood pressure variability in over 56,000 individuals with nearly 17 million measurements American Journal of Hypertension  2018 31:566-573  DOI:10.1093/ajh/hpx221  PMID:29365036  PMCID:PMC5905665
    • Muse, E. D., Wineinger, N. E., Spencer, E. G., Peters, M., Henderson, R., Zhang, Y., Barrett, P. M., Rivera, S. P., Wohlgemuth, J. G., Devlin, J. J., Shiffman, D., Topol, E. J. Validation of a genetic risk score for atrial fibrillation: A prospective multicenter cohort study PLoS Medicine  2018 15  DOI:10.1371/journal.pmed.1002525  PMID:29534064  PMCID:PMC5849279
    • Walters, K. M., Simon, R. A., Woessner, K. M., Wineinger, N. E., White, A. A. Effect of misoprostol on patients with aspirin-exacerbated respiratory disease undergoing aspirin challenge and desensitization Annals of Allergy Asthma & Immunology  2017 119:71-76  DOI:10.1016/j.anai.2017.05.003  PMID:28668243
    • Cook, K. A., Modena, B. D., Wineinger, N. E., Woessner, K. M., Simon, R. A., White, A. A. Use of a composite symptom score during challenge in patients with suspected aspirin-exacerbated respiratory disease Annals of Allergy Asthma & Immunology  2017 118:597-602  DOI:10.1016/j.anai.2017.02.016  PMID:28477789
    • Li, Q., Wineinger, N. E., Fu, D. J., Libiger, O., Alphs, L., Savitz, A., Gopal, S., Cohen, N., Schork, N. J. Genome-wide association study of paliperidone efficacy Pharmacogenetics and Genomics  2017 27:7-18  DOI:10.1097/fpc.0000000000000250  PMID:27846195  PMCID:PMC5152628
    • Yin, X., Wineinger, N. E., Wang, K., Yue, W., Norgren, N., Wang, L., Yao, W., Jiang, X., Wu, B., Cui, Y., Shen, C., Cheng, H., et al. Common susceptibility variants are shared between schizophrenia and psoriasis in the Han Chinese population Journal of Psychiatry & Neuroscience  2016 41:413-421  DOI:10.1503/jpn.150210  PMID:27091718  PMCID:PMC5082512
    • Kim, J. Y., Wineinger, N. E., Taitel, M., Radin, J. M., Akinbosoye, O., Jiang, J., Nikzad, N., Orr, G., Topol, E., Steinhubl, S. Self-monitoring utilization patterns among individuals in an incentivized program for healthy behaviors Journal of Medical Internet Research  2016 18:83-97  DOI:10.2196/jmir.6371  PMID:27856407
    • Cabana-Dominguez, J., Roncero, C., Grau-Lopez, L., Rodriguez-Cintas, L., Barral, C., Abad, A. C., Erikson, G., Wineinger, N. E., Torrico, B., Arenas, C., Casas, M., Ribases, M., et al. A highly polymorphic copy number variant in the NSF gene is associated with cocaine dependence Scientific Reports  2016 6  DOI:10.1038/srep31033  PMID:27498889  PMCID:PMC4976312
    • Gollamudi, S. S., Topol, E. J., Wineinger, N. E. A framework for smartphone-enabled, patient-generated health data analysis PeerJ  2016 4  DOI:10.7717/peerj.2284  PMID:27547580  PMCID:PMC4975026
    • Alvarez-Garcia, O., Fisch, K. M., Wineinger, N. E., Akagi, R., Saito, M., Sasho, T., Su, A. I., Lotz, M. K. Increased DNA methylation and reduced expression of transcription factors in human osteoarthritis cartilage Arthritis & Rheumatology  2016 68:1876-1886  DOI:10.1002/art.39643  PMID:26881698  PMCID:PMC4963260
    • Kim, J. Y., Wineinger, N. E., Steinhubl, S. R. The influence of wireless self-monitoring program on the relationship between patient activation and health behaviors, medication adherence, and blood pressure levels in hypertensive patients: a substudy of a randomized controlled trial Journal of Medical Internet Research  2016 18  DOI:10.2196/jmir.5429  PMID:27334418  PMCID:PMC4935792
    • Erikson, G. A., Bodian, D. L., Rueda, M., Molparia, B., Scott, E. R., Scott-Van Zeeland, A. A., Topol, S. E., Wineinger, N. E., Niederhuber, J. E., Topol, E. J., Torkamani, A. Whole-genome sequencing of a healthy aging cohort Cell  2016 165:1002-1011  DOI:10.1016/j.cell.2016.03.022  PMID:27114037  PMCID:PMC4860090
    • Bloss, C. S., Wineinger, N. E., Peters, M., Boeldt, D. L., Ariniello, L., Kim, J. Y., Sheard, J., Komatireddy, R., Barrett, P., Topol, E. J. A prospective randomized trial examining health care utilization in individuals using multiple smartphone-enabled biosensors PeerJ  2016 4  DOI:10.7717/peerj.1554  PMID:26788432  PMCID:PMC4715435
    • Sieberts, S. K., Zhu, F., Garcia-Garcia, J., Stahl, E., Pratap, A., Pandey, G., Pappas, D., Aguilar, D., Anton, B., Bonet, J., Eksi, R., Fornes, O., et al. Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis Nature Communications  2016 7  DOI:10.1038/ncomms12460  PMID:27549343  PMCID:PMC4996969
    • Johnson, L., Zhu, J., Scott, E. R., Wineinger, N. E. An examination of the relationship between lipid levels and associated genetic markers across racial/ethnic populations in the multi-ethnic study of atherosclerosis PLoS One  2015 10  DOI:10.1371/journal.pone.0126361  PMID:25951326  PMCID:PMC4423846
    • Yin, X., Cheng, H., Lin, Y., Wineinger, N. E., Zhou, F., Sheng, Y., Yang, C., Li, P., Li, F., Shen, C., Yang, S., Schork, N. J., et al. A weighted polygenic risk score using 14 known susceptibility variants to estimate risk and age onset of psoriasis in han chinese PLoS One  2015 10:e0125369  DOI:10.1371/journal.pone.0125369  PMID:25933357  PMCID:PMC4416725
    • Rajan, J. P., Wineinger, N. E., Stevenson, D. D., White, A. A. Prevalence of aspirin-exacerbated respiratory disease among asthmatic patients: A meta-analysis of the literature Journal of Allergy and Clinical Immunology  2015 135:676-U140  DOI:10.1016/j.jaci.2014.08.020  PMID:25282015
    • Boeldt, D. L., Wineinger, N. E., Waalen, J., Gollamudi, S., Grossberg, A., Steinhubl, S. R., McCollister-Slipp, A., Rogers, M. A., Silvers, C., Topol, E. J. How consumers and physicians view new medical technology: comparative survey Journal of Medical Internet Research  2015 17:e215  DOI:10.2196/jmir.4456  PMID:26369254  PMCID:PMC4642377
    • Klimentidis, Y. C., Zhou, J., Wineinger, N. E. Identification of allelic heterogeneity at type-2 diabetes loci and impact on prediction PLoS One  2014 9  DOI:10.1371/journal.pone.0113072  PMID:25393876  PMCID:PMC4231111
    • Klimentidis, Y. C., Wineinger, N. E., Vazquez, A. I., de los Campos, G. Multiple metabolic genetic risk scores and type 2 diabetes risk in three racial/ethnic groups Journal of Clinical Endocrinology & Metabolism  2014 99:E1814-E1818  DOI:10.1210/jc.2014-1818  PMID:24905067  PMCID:PMC4154088
    • Khan, H. A., Wineinger, N. E., Uddin, P. Q., Mehta, H. S., Rubenson, D. S., Topol, E. J. Can hospital rounds with pocket ultrasound by cardiologists reduce standard echocardiography? American Journal of Medicine  2014 127:669.e1-669.e7  DOI:10.1016/j.amjmed.2014.03.015  PMID:24674919  PMCID:PMC4074438
    • Nievergelt, C. M., Wineinger, N. E., Libiger, O., Pham, P., Zhang, G., Baker, D. G., Marine Resiliency Study Investigators, Schork, N. J. Chip-based direct genotyping of coding variants in genome wide association studies: utility, issues and prospects Gene  2014 540:104-109  DOI:10.1016/j.gene.2014.01.069  PMID:24521671  PMCID:PMC3980715
    • Yin, X., Wineinger, N. E., Cheng, H., Cui, Y., Zhou, F., Zuo, X., Zheng, X., Yang, S., Schork, N. J., Zhang, X. Common variants explain a large fraction of the variability in the liability to psoriasis in a Han Chinese population BMC Genomics  2014 15:87  DOI:10.1186/1471-2164-15-87  PMID:24479639  PMCID:PMC3909441
    • Scott-Van Zeeland, A. A., Bloss, C. S., Tewhey, R., Bansal, V., Torkamani, A., Libiger, O., Duvvuri, V., Wineinger, N., Galvez, L., Darst, B. F., Smith, E. N., Carson, A., et al. Evidence for the role of EPHX2 gene variants in anorexia nervosa Molecular Psychiatry  2014 19:724-732  DOI:10.1038/mp.2013.91  PMID:23999524  PMCID:PMC3852189
    • Bloss, C. S., Wineinger, N. E., Darst, B. F., Schork, N. J., Topol, E. J. Impact of direct-to-consumer genomic testing at long term follow-up Journal of Medical Genetics  2013 393-400  DOI:10.1136/jmedgenet-2012-101207  PMID:23559530
    • Falola, M. I., Wiener, H. W., Wineinger, N. E., Cutter, G. R., Kimberly, R. P., Edberg, J. C., Arnett, D. K., Kaslow, R. A., Tang, J., Shrestha, S. Genomic copy number variants: evidence for association with antibody response to anthrax vaccine adsorbed PLoS One  2013 8  DOI:10.1371/journal.pone.0064813  PMID:23741398  PMCID:PMC3669407
    • Wineinger, N. E., Harper, A., Libiger, O., Srinivasan, S. R., Chen, W., Berenson, G. S., Schork, N. J. Genomic risk models improve prediction of longitudinal lipid levels in children and young adults Frontiers in Genetics  2013 4:86  DOI:10.3389/fgene.2013.00086  PMID:23734161  PMCID:PMC3659298
    • Zhao, W., Wineinger, N. E., Tiwari, H. K., Mosley, T. H., Broeckel, U., Arnett, D. K., Kardia, S. L. R., Kabagambe, E. K., Sun, Y. V. Copy number variations associated with obesity-related traits in African Americans: a joint analysis between GENOA and HyperGEN Obesity  2012 20:2431-2437  DOI:10.1038/oby.2012.162  PMID:22836685  PMCID:PMC3484176
    • Wineinger, N. E., Tiwari, H. K. The impact of errors in copy number variation detection algorithms on association results PLoS One  2012 7  DOI:10.1371/journal.pone.0032396  PMID:22523537  PMCID:PMC3327691
    • Forsberg, L. A., Rasi, C., Razzaghian, H. R., Pakalapati, G., Waite, L., Thilbeault, K. S., Ronowicz, A., Wineinger, N. E., Tiwari, H. K., Boomsma, D., Westerman, M. P., Harris, J. R., et al. Age-related somatic structural changes in the nuclear genome of human blood cells American Journal of Human Genetics  2012 90:217-228  DOI:10.1016/j.ajhg.2011.12.009  PMID:22305530  PMCID:PMC3276669
    • Wineinger, N. E., Pajewski, N. M., Kennedy, R. E., Wojczynski, M. K., Vaughan, L. K., Hunt, S. C., Gu, C. C., Rao, D. C., Lorier, R., Broeckel, U., Arnett, D. K., Tiwari, H. K. Characterization of autosomal copy-number variation in African Americans: the HyperGEN Study European Journal of Human Genetics  2011 19:1271-1275  DOI:10.1038/ejhg.2011.115  PMID:21673747  PMCID:PMC3230358
    • Irvin, M. R., Wineinger, N. E., Rice, T. K., Pajewski, N. M., Kabagambe, E. K., Gu, C. C., Pankow, J., North, K. E., Wilk, J. B., Freedman, B. I., Franceschini, N., Broeckel, U., et al. Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study Plos One  2011 6  DOI:10.1371/journal.pone.0024052  PMID:21901158  PMCID:PMC3162025
    • Wineinger, N. E., Patki, A., Meyers, K. J., Broeckel, U., Gu, C. C., Rao, D. C., Devereux, R. B., Arnett, D. K., Tiwari, H. K. Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study BMC Medical Genomics  2011 4  DOI:10.1186/1755-8794-4-4  PMID:21223598  PMCID:PMC3027088
    • Tiwari, H. K., Barnholtz-Sloan, J., Wineinger, N., Padilla, M. A., Vaughan, L. K., Allison, D. B. Review and evaluation of methods correcting for population stratification with a focus on underlying statistical principles Human Heredity  2008 66:67-86  DOI:10.1159/000119107  PMID:18382087  PMCID:PMC2803696
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Background

education and training

  • Ph.D. in Biostatistics, The University of Alabama at Birmingham 2011
  • B.A. in Mathematics, Grinnell College 2001 - 2005
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Contact

full name

  • Nathan E. Wineinger

geographic location

  • Scripps California 

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