recent publications
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academic article
- Jaiswal, S. J., Kang, D. Y., Wineinger, N. E., Owens, R. L. Objectively measured sleep fragmentation is associated with incident delirium in older hospitalized patients: Analysis of data collected from an randomized controlled trial Journal of Sleep Research 2020 DOI:10.1111/jsr.13205 PMID:33051948
- Giraldez, S., Tamayo, P., Wineinger, N., Kim, W., Reed, S. I. Cyclin E overexpression in human mammary epithelial cells promotes epithelial cancer-specific copy number alterations iScience 2019 19:850-859 DOI:10.1016/j.isci.2019.08.043 PMID:31513970 PMCID:PMC6739637
- Wineinger, N. E., Barrett, P. M., Zhang, Y., Irfanullah, I., Muse, E. D., Steinhubl, S. R., Topol, E. J. Identification of paroxysmal atrial fibrillation subtypes in over 13,000 individuals Heart Rhythm 2019 16:26-30 DOI:10.1016/j.hrthm.2018.08.012 PMID:30118885
- Klimentidis, Y. C., Raichlen, D. A., Bea, J., Garcia, D. O., Wineinger, N. E., Mandarino, L. J., Alexander, G. E., Chen, Z., Going, S. B. In response to: 'Information bias in measures of self-reported physical activity' International Journal of Obesity 2018 42:2064-2065 DOI:10.1038/s41366-018-0251-6 PMID:30464230
- Jaiswal, S. J., McCarthy, T. J., Wineinger, N. E., Kang, D. Y., Song, J., Garcia, S., van Niekerk, C. J., Lu, C. Y., Loeks, M., Owens, R. L. Melatonin and sleep in preventing hospitalized delirium: a randomized clinical trial American Journal of Medicine 2018 131:1110-1117 DOI:10.1016/j.amjmed.2018.04.009 PMID:29729237 PMCID:PMC6163056
- Torkamani, A., Wineinger, N. E., Topol, E. J. The personal and clinical utility of polygenic risk scores Nature Reviews Genetics 2018 19:581-590 DOI:10.1038/s41576-018-0018-x PMID:29789686
- Klimentidis, Y. C., Raichlen, D. A., Bea, J., Garcia, D. O., Wineinger, N. E., Mandarino, L. J., Alexander, G. E., Chen, Z., Going, S. B. Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE International Journal of Obesity 2018 42:1161-1176 DOI:10.1038/s41366-018-0120-3 PMID:29899525
- Kim, K. I., Nikzad, N., Quer, G., Wineinger, N. E., Vegreville, M., Normand, A., Schmidt, N., Topol, E. J., Steinhubl, S. Real world home blood pressure variability in over 56,000 individuals with nearly 17 million measurements American Journal of Hypertension 2018 31:566-573 DOI:10.1093/ajh/hpx221 PMID:29365036 PMCID:PMC5905665
- Muse, E. D., Wineinger, N. E., Spencer, E. G., Peters, M., Henderson, R., Zhang, Y., Barrett, P. M., Rivera, S. P., Wohlgemuth, J. G., Devlin, J. J., Shiffman, D., Topol, E. J. Validation of a genetic risk score for atrial fibrillation: A prospective multicenter cohort study PLoS Medicine 2018 15 DOI:10.1371/journal.pmed.1002525 PMID:29534064 PMCID:PMC5849279
- Walters, K. M., Simon, R. A., Woessner, K. M., Wineinger, N. E., White, A. A. Effect of misoprostol on patients with aspirin-exacerbated respiratory disease undergoing aspirin challenge and desensitization Annals of Allergy Asthma & Immunology 2017 119:71-76 DOI:10.1016/j.anai.2017.05.003 PMID:28668243
- Cook, K. A., Modena, B. D., Wineinger, N. E., Woessner, K. M., Simon, R. A., White, A. A. Use of a composite symptom score during challenge in patients with suspected aspirin-exacerbated respiratory disease Annals of Allergy Asthma & Immunology 2017 118:597-602 DOI:10.1016/j.anai.2017.02.016 PMID:28477789
- Li, Q., Wineinger, N. E., Fu, D. J., Libiger, O., Alphs, L., Savitz, A., Gopal, S., Cohen, N., Schork, N. J. Genome-wide association study of paliperidone efficacy Pharmacogenetics and Genomics 2017 27:7-18 DOI:10.1097/fpc.0000000000000250 PMID:27846195 PMCID:PMC5152628
- Yin, X., Wineinger, N. E., Wang, K., Yue, W., Norgren, N., Wang, L., Yao, W., Jiang, X., Wu, B., Cui, Y., Shen, C., Cheng, H., et al. Common susceptibility variants are shared between schizophrenia and psoriasis in the Han Chinese population Journal of Psychiatry & Neuroscience 2016 41:413-421 DOI:10.1503/jpn.150210 PMID:27091718 PMCID:PMC5082512
- Kim, J. Y., Wineinger, N. E., Taitel, M., Radin, J. M., Akinbosoye, O., Jiang, J., Nikzad, N., Orr, G., Topol, E., Steinhubl, S. Self-monitoring utilization patterns among individuals in an incentivized program for healthy behaviors Journal of Medical Internet Research 2016 18:83-97 DOI:10.2196/jmir.6371 PMID:27856407
- Cabana-Dominguez, J., Roncero, C., Grau-Lopez, L., Rodriguez-Cintas, L., Barral, C., Abad, A. C., Erikson, G., Wineinger, N. E., Torrico, B., Arenas, C., Casas, M., Ribases, M., et al. A highly polymorphic copy number variant in the NSF gene is associated with cocaine dependence Scientific Reports 2016 6 DOI:10.1038/srep31033 PMID:27498889 PMCID:PMC4976312
- Gollamudi, S. S., Topol, E. J., Wineinger, N. E. A framework for smartphone-enabled, patient-generated health data analysis PeerJ 2016 4 DOI:10.7717/peerj.2284 PMID:27547580 PMCID:PMC4975026
- Alvarez-Garcia, O., Fisch, K. M., Wineinger, N. E., Akagi, R., Saito, M., Sasho, T., Su, A. I., Lotz, M. K. Increased DNA methylation and reduced expression of transcription factors in human osteoarthritis cartilage Arthritis & Rheumatology 2016 68:1876-1886 DOI:10.1002/art.39643 PMID:26881698 PMCID:PMC4963260
- Kim, J. Y., Wineinger, N. E., Steinhubl, S. R. The influence of wireless self-monitoring program on the relationship between patient activation and health behaviors, medication adherence, and blood pressure levels in hypertensive patients: a substudy of a randomized controlled trial Journal of Medical Internet Research 2016 18 DOI:10.2196/jmir.5429 PMID:27334418 PMCID:PMC4935792
- Erikson, G. A., Bodian, D. L., Rueda, M., Molparia, B., Scott, E. R., Scott-Van Zeeland, A. A., Topol, S. E., Wineinger, N. E., Niederhuber, J. E., Topol, E. J., Torkamani, A. Whole-genome sequencing of a healthy aging cohort Cell 2016 165:1002-1011 DOI:10.1016/j.cell.2016.03.022 PMID:27114037 PMCID:PMC4860090
- Bloss, C. S., Wineinger, N. E., Peters, M., Boeldt, D. L., Ariniello, L., Kim, J. Y., Sheard, J., Komatireddy, R., Barrett, P., Topol, E. J. A prospective randomized trial examining health care utilization in individuals using multiple smartphone-enabled biosensors PeerJ 2016 4 DOI:10.7717/peerj.1554 PMID:26788432 PMCID:PMC4715435
- Sieberts, S. K., Zhu, F., Garcia-Garcia, J., Stahl, E., Pratap, A., Pandey, G., Pappas, D., Aguilar, D., Anton, B., Bonet, J., Eksi, R., Fornes, O., et al. Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis Nature Communications 2016 7 DOI:10.1038/ncomms12460 PMID:27549343 PMCID:PMC4996969
- Johnson, L., Zhu, J., Scott, E. R., Wineinger, N. E. An examination of the relationship between lipid levels and associated genetic markers across racial/ethnic populations in the multi-ethnic study of atherosclerosis PLoS One 2015 10 DOI:10.1371/journal.pone.0126361 PMID:25951326 PMCID:PMC4423846
- Yin, X., Cheng, H., Lin, Y., Wineinger, N. E., Zhou, F., Sheng, Y., Yang, C., Li, P., Li, F., Shen, C., Yang, S., Schork, N. J., et al. A weighted polygenic risk score using 14 known susceptibility variants to estimate risk and age onset of psoriasis in han chinese PLoS One 2015 10:e0125369 DOI:10.1371/journal.pone.0125369 PMID:25933357 PMCID:PMC4416725
- Rajan, J. P., Wineinger, N. E., Stevenson, D. D., White, A. A. Prevalence of aspirin-exacerbated respiratory disease among asthmatic patients: A meta-analysis of the literature Journal of Allergy and Clinical Immunology 2015 135:676-U140 DOI:10.1016/j.jaci.2014.08.020 PMID:25282015
- Boeldt, D. L., Wineinger, N. E., Waalen, J., Gollamudi, S., Grossberg, A., Steinhubl, S. R., McCollister-Slipp, A., Rogers, M. A., Silvers, C., Topol, E. J. How consumers and physicians view new medical technology: comparative survey Journal of Medical Internet Research 2015 17:e215 DOI:10.2196/jmir.4456 PMID:26369254 PMCID:PMC4642377
- Klimentidis, Y. C., Zhou, J., Wineinger, N. E. Identification of allelic heterogeneity at type-2 diabetes loci and impact on prediction PLoS One 2014 9 DOI:10.1371/journal.pone.0113072 PMID:25393876 PMCID:PMC4231111
- Klimentidis, Y. C., Wineinger, N. E., Vazquez, A. I., de los Campos, G. Multiple metabolic genetic risk scores and type 2 diabetes risk in three racial/ethnic groups Journal of Clinical Endocrinology & Metabolism 2014 99:E1814-E1818 DOI:10.1210/jc.2014-1818 PMID:24905067 PMCID:PMC4154088
- Khan, H. A., Wineinger, N. E., Uddin, P. Q., Mehta, H. S., Rubenson, D. S., Topol, E. J. Can hospital rounds with pocket ultrasound by cardiologists reduce standard echocardiography? American Journal of Medicine 2014 127:669.e1-669.e7 DOI:10.1016/j.amjmed.2014.03.015 PMID:24674919 PMCID:PMC4074438
- Nievergelt, C. M., Wineinger, N. E., Libiger, O., Pham, P., Zhang, G., Baker, D. G., Marine Resiliency Study Investigators, Schork, N. J. Chip-based direct genotyping of coding variants in genome wide association studies: utility, issues and prospects Gene 2014 540:104-109 DOI:10.1016/j.gene.2014.01.069 PMID:24521671 PMCID:PMC3980715
- Yin, X., Wineinger, N. E., Cheng, H., Cui, Y., Zhou, F., Zuo, X., Zheng, X., Yang, S., Schork, N. J., Zhang, X. Common variants explain a large fraction of the variability in the liability to psoriasis in a Han Chinese population BMC Genomics 2014 15:87 DOI:10.1186/1471-2164-15-87 PMID:24479639 PMCID:PMC3909441
- Scott-Van Zeeland, A. A., Bloss, C. S., Tewhey, R., Bansal, V., Torkamani, A., Libiger, O., Duvvuri, V., Wineinger, N., Galvez, L., Darst, B. F., Smith, E. N., Carson, A., et al. Evidence for the role of EPHX2 gene variants in anorexia nervosa Molecular Psychiatry 2014 19:724-732 DOI:10.1038/mp.2013.91 PMID:23999524 PMCID:PMC3852189
- Bloss, C. S., Wineinger, N. E., Darst, B. F., Schork, N. J., Topol, E. J. Impact of direct-to-consumer genomic testing at long term follow-up Journal of Medical Genetics 2013 393-400 DOI:10.1136/jmedgenet-2012-101207 PMID:23559530
- Falola, M. I., Wiener, H. W., Wineinger, N. E., Cutter, G. R., Kimberly, R. P., Edberg, J. C., Arnett, D. K., Kaslow, R. A., Tang, J., Shrestha, S. Genomic copy number variants: evidence for association with antibody response to anthrax vaccine adsorbed PLoS One 2013 8 DOI:10.1371/journal.pone.0064813 PMID:23741398 PMCID:PMC3669407
- Wineinger, N. E., Harper, A., Libiger, O., Srinivasan, S. R., Chen, W., Berenson, G. S., Schork, N. J. Genomic risk models improve prediction of longitudinal lipid levels in children and young adults Frontiers in Genetics 2013 4:86 DOI:10.3389/fgene.2013.00086 PMID:23734161 PMCID:PMC3659298
- Zhao, W., Wineinger, N. E., Tiwari, H. K., Mosley, T. H., Broeckel, U., Arnett, D. K., Kardia, S. L. R., Kabagambe, E. K., Sun, Y. V. Copy number variations associated with obesity-related traits in African Americans: a joint analysis between GENOA and HyperGEN Obesity 2012 20:2431-2437 DOI:10.1038/oby.2012.162 PMID:22836685 PMCID:PMC3484176
- Wineinger, N. E., Tiwari, H. K. The impact of errors in copy number variation detection algorithms on association results PLoS One 2012 7 DOI:10.1371/journal.pone.0032396 PMID:22523537 PMCID:PMC3327691
- Forsberg, L. A., Rasi, C., Razzaghian, H. R., Pakalapati, G., Waite, L., Thilbeault, K. S., Ronowicz, A., Wineinger, N. E., Tiwari, H. K., Boomsma, D., Westerman, M. P., Harris, J. R., et al. Age-related somatic structural changes in the nuclear genome of human blood cells American Journal of Human Genetics 2012 90:217-228 DOI:10.1016/j.ajhg.2011.12.009 PMID:22305530 PMCID:PMC3276669
- Wineinger, N. E., Pajewski, N. M., Kennedy, R. E., Wojczynski, M. K., Vaughan, L. K., Hunt, S. C., Gu, C. C., Rao, D. C., Lorier, R., Broeckel, U., Arnett, D. K., Tiwari, H. K. Characterization of autosomal copy-number variation in African Americans: the HyperGEN Study European Journal of Human Genetics 2011 19:1271-1275 DOI:10.1038/ejhg.2011.115 PMID:21673747 PMCID:PMC3230358
- Irvin, M. R., Wineinger, N. E., Rice, T. K., Pajewski, N. M., Kabagambe, E. K., Gu, C. C., Pankow, J., North, K. E., Wilk, J. B., Freedman, B. I., Franceschini, N., Broeckel, U., et al. Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study Plos One 2011 6 DOI:10.1371/journal.pone.0024052 PMID:21901158 PMCID:PMC3162025
- Wineinger, N. E., Patki, A., Meyers, K. J., Broeckel, U., Gu, C. C., Rao, D. C., Devereux, R. B., Arnett, D. K., Tiwari, H. K. Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study BMC Medical Genomics 2011 4 DOI:10.1186/1755-8794-4-4 PMID:21223598 PMCID:PMC3027088
- Tiwari, H. K., Barnholtz-Sloan, J., Wineinger, N., Padilla, M. A., Vaughan, L. K., Allison, D. B. Review and evaluation of methods correcting for population stratification with a focus on underlying statistical principles Human Heredity 2008 66:67-86 DOI:10.1159/000119107 PMID:18382087 PMCID:PMC2803696