recent publications

• All Publications
• PubMed Display for Export
• Publications without PubMed PMIDs

• academic article

  • Muse, E. D., Topol, E. J. A brighter future for kidney disease? Lancet  2020 395:179-179  PMID:31954451
  • Berzin, T. M., Topol, E. J. Adding artificial intelligence to gastrointestinal endoscopy Lancet  2020 395:485-485  PMID:32061286
  • Topol, E. J. A decade of digital medicine innovation Science Translational Medicine  2019 11  DOI:10.1126/scitranslmed.aaw7610  PMID:31243153
  • Esteva, A., Topol, E. Can skin cancer diagnosis be transformed by AI? Lancet  2019 394:1795-1795
  • Ensign, S. F., Baca-Motes, K., Steinhubl, S. R., Topol, E. J. Characteristics of the modern-day physician house call Medicine  2019 98  DOI:10.1097/md.0000000000014671  PMID:30813215  PMCID:PMC6408061
  • Topol, E. J. Deep learning detects impending organ injury Nature  2019 572:36-37  DOI:10.1038/d41586-019-02308-x  PMID:31367025
  • Evangelista, L., Steinhubl, S. R., Topol, E. J. Digital health care for older adults Lancet  2019 393:1493-1493  DOI:10.1016/s0140-6736(19)30800-1  PMID:30983579
  • Keane, P., Topol, E. Digital medicine Reinventing the eye exam Lancet  2019 394:2141-2141
  • Oran, D. P., Topol, E. J. Digital medicine The rise of the virtualist Lancet  2019 394:17-17  DOI:10.1377/hblog20180319.150005
  • Muse, E. D., Topol, E. J. Digital orthodoxy of human data collection Lancet  2019 394:556-556  PMID:31423988
  • Jaiswal, S. J., Topol, E. J., Steinhubl, S. R. Digitising the way to better sleep health Lancet  2019 393:639-639  DOI:10.1001/jamapsychiatry.2018.2745  PMID:30782334
  • Spencer, E. G., Topol, E. J. Direct to consumer fitness DNA testing Clinical Chemistry  2019 65:45-47  DOI:10.1373/clinchem.2018.287326  PMID:30274978
  • Pandey, A. C., Topol, E. J. Dispense with supplements for improving heart outcomes Annals of Internal Medicine  2019 171:216-217  DOI:10.7326/m19-1498  PMID:31284306
  • Topol, E. J. Everybody wants to go to heaven but nobody wants to die: bioethics and the transformation of health care in america Nature  2019 572:308-309  DOI:10.1038/d41586-019-02412-y
  • Topol, E. J. High-performance medicine: the convergence of human and artificial intelligence Nature Medicine  2019 25:44-56  DOI:10.1038/s41591-018-0300-7  PMID:30617339
  • Wineinger, N. E., Barrett, P. M., Zhang, Y., Irfanullah, I., Muse, E. D., Steinhubl, S. R., Topol, E. J. Identification of paroxysmal atrial fibrillation subtypes in over 13,000 individuals Heart Rhythm  2019 16:26-30  DOI:10.1016/j.hrthm.2018.08.012  PMID:30118885
  • Topol, E., Lee, K. F. It takes a planet Nature Biotechnology  2019 37:858-861  DOI:10.1038/s41587-019-0214-z  PMID:31375799
  • Regev, A., Zhang, F., Jaffee, E., Farrar, J., Nkengasong, J., Topol, E., Partridge, L., Mundel, T., Tabernero, J., Sabeti, P., Toreele, E. Looking forward 25 years: the future of medicine Nature Medicine  2019 25:1804-1807  DOI:10.1038/s41591-019-0693-y  PMID:31806889
  • Topol, E. Man and machine medicine Scientist  2019 33:61-61
  • Kumar, A., Thomas, S. K., Wong, K. C., Lo Sardo, V., Cheah, D. S., Hou, Y. H., Placone, J. K., Tenerelli, K. P., Ferguson, W. C., Torkamani, A., Topol, E. J., Baldwin, K. K., et al. Mechanical activation of noncoding-RNA-mediated regulation of disease-associated phenotypes in human cardiomyocytes Nature Biomedical Engineering  2019 3:137-146  DOI:10.1038/s41551-018-0344-5
  • Torkamani, A., Topol, E. Polygenic risk scores expand to obesity Cell  2019 177:518-520  DOI:10.1016/j.cell.2019.03.051  PMID:31002792
  • Salfati, E. L., Spencer, E. G., Topol, S. E., Muse, E. D., Rueda, M., Lucas, J. R., Wagner, G. N., Campman, S., Topol, E. J., Torkamani, A. Re-analysis of whole-exome sequencing data uncovers novel diagnostic variants and improves molecular diagnostic yields for sudden death and idiopathic diseases Genome Medicine  2019 11  DOI:10.1186/s13073-019-0702-2  PMID:31847883  PMCID:PMC6916453
  • Waalen, J., Peters, M., Ranamukhaarachchi, D., Li, J., Ebner, G., Senkowsky, J., Topol, E. J., Steinhubl, S. R. Real world usage characteristics of a novel mobile health self-monitoring device: Results from the Scanadu Consumer Health Outcomes (SCOUT) Study PLoS One  2019 14  DOI:10.1371/journal.pone.0215468  PMID:30990860  PMCID:PMC6467418
  • Chan, J., Raju, S. C., Topol, E. Towards a tricorder for diagnosing paediatric conditions Lancet  2019 394:907-907  DOI:10.1016/s0140-6736(19)32087-2
  • Hamideh, D., Arellano, B., Topol, E. J., Steinhubl, S. R. Your digital nutritionist Lancet  2019 393:19-19  DOI:10.1016/s0140-6736(18)33170-2  PMID:30614448
  • Radin, J. M., Topol, E. J., Steinhubl, S. R. A digital toolkit for improved maternal health Lancet  2018 392:1107-1107  DOI:10.1016/s0140-6736(18)32294-3
  • Steinhubl, S. R., Topol, E. J. A skin patch for sensing blood pressures Nature Biomedical Engineering  2018 2:633-634  DOI:10.1038/s41551-018-0296-9
  • Modena, B. D., Bellahsen, O., Nikzad, N., Chieh, A., Parikh, N., Dufek, D. M., Ebner, G., Topol, E. J., Steinhubl, S. Advanced and accurate mobile health tracking devices record new cardiac vital signs Hypertension  2018 72:503-510  DOI:10.1161/hypertensionaha.118.11177  PMID:29967036  PMCID:PMC6044460
  • Wang, F., Wang, I. Z., Ellis, S., Archacki, S., Barnard, J., Hubbard, C., Topol, E. J., Chen, Q., Wang, Q. K. Analysis of causal effect of APOA5 variants on premature coronary artery disease Annals of Human Genetics  2018 82:437-447  DOI:10.1111/ahg.12273  PMID:30024021  PMCID:PMC6188800
  • Topol, E. Bad blood secrets and lies in a Silicon Valley startup Nature  2018 557:306-307
  • Song, M. Y., Steinhubl, S. R., Topol, E. J. Digital medicine: The beginning of the end of fingersticks? Lancet  2018 392:203-203  DOI:10.1016/s0140-6736(18)31576-9
  • Steinhubl, S. R., Waalen, J., Edwards, A. M., Ariniello, L. M., Mehta, R. R., Ebner, G. S., Carter, C., Baca-Motes, K., Felicione, E., Sarich, T., Topol, E. J. Effect of a home-based wearable continuous ECG monitoring patch on detection of undiagnosed atrial fibrillation the mSToPS randomized clinical trial JAMA-Journal of the American Medical Association  2018 320:146-155  DOI:10.1001/jama.2018.8102  PMID:29998336
  • Quer, G., Nikzad, N., Chieh, A., Normand, A., Vegreville, M., Topol, E. J., Steinhubl, S. R. Home monitoring of blood pressure: short-term changes during serial measurements for 56398 subjects Ieee Journal of Biomedical and Health Informatics  2018 22:1691-1698  DOI:10.1109/jbhi.2017.2776946  PMID:29989995  PMCID:PMC6053341
  • Dharajiya, N. G., Grosu, D. S., Farkas, D. H., McCullough, R. M., Almasri, E., Sun, Y., Kim, S. K., Jensen, T. J., Saldivar, J. S., Topol, E. J., van den Boom, D., Ehrich, M. Incidental detection of maternal neoplasia in noninvasive prenatal testing Clinical Chemistry  2018 64:329-335  DOI:10.1373/clinchem.2017.277517  PMID:28982650
  • Jha, S., Topol, E. J. Information and artificial intelligence Journal of the American College of Radiology  2018 15:509-511  DOI:10.1016/j.jacr.2017.12.025
  • Tarassenko, L., Topol, E. J. Monitoring jet engines and the health of people JAMA-Journal of the American Medical Association  2018 320:2309-2310  DOI:10.1001/jama.2018.16558  PMID:30453330
  • Steinhubl, S. R., Topol, E. J. Now we're talking: bringing a voice to digital medicine Lancet  2018 392:627-627
  • Mikk, K. A., Sleeper, H. A., Topol, E. Patient data ownership reply JAMA-Journal of the American Medical Association  2018 319:935-936  DOI:10.1001/jama.2017.21688  PMID:29509862
  • Kim, K. I., Nikzad, N., Quer, G., Wineinger, N. E., Vegreville, M., Normand, A., Schmidt, N., Topol, E. J., Steinhubl, S. Real world home blood pressure variability in over 56,000 individuals with nearly 17 million measurements American Journal of Hypertension  2018 31:566-573  DOI:10.1093/ajh/hpx221  PMID:29365036  PMCID:PMC5905665
  • Telenti, A., Steinhubl, S. R., Topol, E. J. Rethinking the medical record Lancet  2018 391:1013-1013  PMID:29565009
  • Torkamani, A., Wineinger, N. E., Topol, E. J. The personal and clinical utility of polygenic risk scores Nature Reviews Genetics  2018 19:581-590  DOI:10.1038/s41576-018-0018-x  PMID:29789686
  • Lo Sardo, V., Chubukov, P., Ferguson, W., Kumar, A., Teng, E. L., Duran, M., Zhang, L., Cost, G., Engler, A. J., Urnov, F., Topol, E. J., Torkamani, A., et al. Unveiling the role of the most impactful cardiovascular risk locus through haplotype editing Cell  2018 175:1796-1810  DOI:10.1016/j.cell.2018.11.014  PMID:30528432
  • Muse, E. D., Wineinger, N. E., Spencer, E. G., Peters, M., Henderson, R., Zhang, Y., Barrett, P. M., Rivera, S. P., Wohlgemuth, J. G., Devlin, J. J., Shiffman, D., Topol, E. J. Validation of a genetic risk score for atrial fibrillation: A prospective multicenter cohort study PLoS Medicine  2018 15  DOI:10.1371/journal.pmed.1002525  PMID:29534064  PMCID:PMC5849279
  • Steinhubl, S. R., Kim, K. I., Ajayi, T., Topol, E. J. Virtual care for improved global health Lancet  2018 391:419-419  PMID:29407024
  • Muse, E. D., Torkamani, A., Topol, E. J. When genomics goes digital Lancet  2018 391:2405-2405  DOI:10.1038/s41576-018-0018-x  PMID:29916375
  • Torkamani, A., Topol, E. Your genome, on demand MIT Technology Review  2018 121:20-21
  • Muse, E. D., Kramer, E. R., Wang, H. Y., Barrett, P., Parviz, F., Novotny, M. A., Lasken, R. S., Jatkoe, T. A., Oliveira, G., Peng, H. F., Lu, J., Connelly, M. C., et al. A whole blood molecular signature for acute myocardial infarction Scientific Reports  2017 7  DOI:10.1038/s41598-017-12166-0  PMID:28947747  PMCID:PMC5612952
  • Quer, G., Muse, E. D., Nikzad, N., Topol, E. J., Steinhubl, S. R. Digital medicine: Augmenting diagnostic vision with AI Lancet  2017 390:221-221
  • Barrett, P. M., Steinhubl, S. R., Muse, E. D., Topol, E. J. Digitising the mind Lancet  2017 389:1877-1877  PMID:28513442
  • Guo, Y., Wang, F., Li, L., Gao, H., Arckacki, S., Wang, I. Z., Barnard, J., Ellis, S., Hubbard, C., Topol, E. J., Chen, Q., Wang, Q. K. Genome-wide linkage analysis of large multiple multigenerational families identifies novel genetic loci for coronary rrtery disease Scientific Reports  2017 7  DOI:10.1038/s41598-017-05381-2  PMID:28710368  PMCID:PMC5511258
  • Torkamani, A., Andersen, K. G., Steinhubl, S. R., Topol, E. J. High-Definition Medicine Cell  2017 170:828-843  DOI:10.1016/j.cell.2017.08.007  PMID:28841416
  • Lo Sardo, V., Ferguson, W., Erikson, G. A., Topol, E. J., Baldwin, K. K., Torkamani, A. Influence of donor age on induced pluripotent stem cells Nature Biotechnology  2017 35:69-74  DOI:10.1038/nbt.3749  PMID:27941802
  • Topol, E. J. Is there an ICD-10 code for hyperbole? JAMA-Journal of the American Medical Association  2017 317:10-11  PMID:28030677
  • Bansal, V., Gassenhuber, J., Phillips, T., Oliveira, G., Harbaugh, R., Villarasa, N., Topol, E. J., Seufferlein, T., Boehm, B. O. Spectrum of mutations in monogenic diabetes genes identified from high-throughput DNA sequencing of 6888 individuals BMC Medicine  2017 15  DOI:10.1186/s12916-017-0977-3  PMID:29207974  PMCID:PMC5717832
  • Steinhubl, S. R., McGovern, P., Dylan, J., Topol, E. J. The digitised clinical trial Lancet  2017 390:2135-2135  PMID:29143747
  • Mikk, K. A., Sleeper, H. A., Topol, E. J. The pathway to patient data ownership and better health JAMA-Journal of the American Medical Association  2017 318:1433-1434  DOI:10.1001/jama.2017.12145  PMID:28973063
  • Muse, E. D., Barrett, P. M., Steinhubl, S. R., Topol, E. J. Towards a smart medical home Lancet  2017 389:358-358  PMID:28137686
  • Gollamudi, S. S., Topol, E. J., Wineinger, N. E. A framework for smartphone-enabled, patient-generated health data analysis PeerJ  2016 4  DOI:10.7717/peerj.2284  PMID:27547580  PMCID:PMC4975026
  • Radin, J. M., Topol, E. J., Andersen, K. G., Steinhubl, S. R. A laboratory in your pocket Lancet  2016 388:1875-1875  PMID:27751390
  • Bloss, C. S., Wineinger, N. E., Peters, M., Boeldt, D. L., Ariniello, L., Kim, J. Y., Sheard, J., Komatireddy, R., Barrett, P., Topol, E. J. A prospective randomized trial examining health care utilization in individuals using multiple smartphone-enabled biosensors PeerJ  2016 4  DOI:10.7717/peerj.1554  PMID:26788432  PMCID:PMC4715435
  • Jha, S., Topol, E. J. Adapting to artificial intelligence radiologists and pathologists as information specialists JAMA-Journal of the American Medical Association  2016 316:2353-2354  DOI:10.1001/jama.2016.17438  PMID:27898975
  • Topol, E. Digital medicine: empowering both patients and clinicians Lancet  2016 388:740-741  PMID:27560260
  • Torkamani, A., Muse, E. D., Spencer, E. G., Rueda, M., Wagner, G. N., Lucas, J. R., Topol, E. J. Molecular autopsy for sudden unexpected death JAMA-Journal of the American Medical Association  2016 316:1492-1494  PMID:27727376
  • Topol, E. J. Money back guarantees for non-reproducible results? BMJ-British Medical Journal  2016 353  DOI:10.1136/bmj.i2770  PMID:27221803
  • Steinhubl, S. R., Muse, E. D., Barrett, P. M., Topol, E. J. Off the cuff : rebooting blood pressure treatment Lancet  2016 388:749-749  PMID:27560266
  • Filkins, B. L., Kim, J. Y., Roberts, B., Armstrong, W., Miller, M. A., Hultner, M. L., Castillo, A. P., Ducom, J. C., Topol, E. J., Steinhubl, S. R. Privacy and security in the era of digital health: what should translational researchers know and do about it? American Journal of Translational Research  2016 8:1560-1580  PMID:27186282  PMCID:PMC4859641
  • Steinhubl, S. R., Mehta, R. R., Ebner, G. S., Ballesteros, M. M., Waalen, J., Steinberg, G., Van Crocker Jr., P., Felicione, E., Carter, C. T., Edmonds, S., Honcz, J. P., Miralles, G. D., et al. Rationale and design of a home-based trial using wearable sensors to detect asymptomatic atrial fibrillation in a targeted population: The mHealth Screening To Prevent Strokes (mSToPS) trial American Heart Journal  2016 175:77-85  DOI:10.1016/j.ahj.2016.02.011  PMID:27179726
  • Kim, J. Y., Wineinger, N. E., Taitel, M., Radin, J. M., Akinbosoye, O., Jiang, J., Nikzad, N., Orr, G., Topol, E., Steinhubl, S. Self-monitoring utilization patterns among individuals in an incentivized program for healthy behaviors Journal of Medical Internet Research  2016 18:83-97  DOI:10.2196/jmir.6371  PMID:27856407
  • Barrett, P. M., Topol, E. J. Smartphone Medicine It Professional  2016 18:52-54
  • Dorsey, E. R., Topol, E. J. State of Telehealth REPLY New England Journal of Medicine  2016 375:1400-1400
  • Dorsey, E. R., Topol, E. J. State of telehealth New England Journal of Medicine  2016 375:154-161  DOI:10.1056/NEJMra1601705  PMID:27410924
  • Wilbanks, J. T., Topol, E. J. Stop the privatization of health data Nature  2016 535:345-348  PMID:27443724
  • Topol, E. The evangelist of individualized medicine Technology Review  2016 119:91-92
  • Barrett, P. M., Topol, E. J. To truly look inside Lancet  2016 387:1268-1269  PMID:27035018
  • Erikson, G. A., Bodian, D. L., Rueda, M., Molparia, B., Scott, E. R., Scott-Van Zeeland, A. A., Topol, S. E., Wineinger, N. E., Niederhuber, J. E., Topol, E. J., Torkamani, A. Whole-genome sequencing of a healthy aging cohort Cell  2016 165:1002-1011  DOI:10.1016/j.cell.2016.03.022  PMID:27114037  PMCID:PMC4860090
  • Guillot, J., Topol, E., Brynjolfsson, E. Fighting for Zach Technology Review  2015 118:10-11
  • Topol, E. Watch This Technology Review  2015 118:11-11
  • Bloss, C. S., Zeeland, A. A. S. V., Topol, S. E., Darst, B. F., Boeldt, D. L., Erikson, G. A., Bethel, K. J., Bjork, R. L., Friedman, J. R., Hwynn, N., Patay, B. A., Pockros, P. J., et al. A genome sequencing program for novel undiagnosed diseases Genetics in Medicine  2015 17:995-1001  DOI:10.1038/gim.2015.21  PMID:25790160  PMCID:PMC4575596
  • Steinhubl, S. R., Wineingeri, N. E., Patel, S., Boeldt, D. L., Mackellar, G., Porter, V., Redmond, J. T., Muse, E. D., Nicholson, L., Chopra, D., Topol, E. J. Cardiovascular and nervous system changes during meditation Frontiers in Human Neuroscience  2015 9  DOI:10.3389/fnhum.2015.00145  PMID:25852526  PMCID:PMC4364161
  • Topol, E. J., Steinhubl, S. R., Torkamani, A. Digital medical tools and sensors JAMA-Journal of the American Medical Association  2015 313:353-354  DOI:10.1001/jama.2014.17125  PMID:25626031  PMCID:PMC4751024
  • Rifai, N., Topol, E., Chan, E., Lo, Y. M. D., Wittwer, C. T. Disruptive innovation in laboratory medicine Clinical Chemistry  2015 61:1129-1132  DOI:10.1373/clinchem.2015.243667  PMID:26152753
  • Boeldt, D. L., Wineinger, N. E., Waalen, J., Gollamudi, S., Grossberg, A., Steinhubl, S. R., McCollister-Slipp, A., Rogers, M. A., Silvers, C., Topol, E. J. How consumers and physicians view new medical technology: comparative survey Journal of Medical Internet Research  2015 17:e215  DOI:10.2196/jmir.4456  PMID:26369254  PMCID:PMC4642377
  • Boeldt, D. L., Schork, N. J., Topol, E. J., Bloss, C. S. Influence of individual differences in disease perception on consumer response to direct-to-consumer genomic testing Clinical Genetics  2015 87:225-232  DOI:10.1111/cge.12419  PMID:24798746  PMCID:PMC4758676
  • Teirstein, P., Topol, E. J. Maintenance of certification and the interstate medical licensure compact reply JAMA-Journal of the American Medical Association  2015 314:952-952  PMID:26325571
  • Steinhubl, S. R., Topol, E. J. Moving from digitalization to digitization in cardiovascular care why is it important, and what could it mean for patients and providers? Journal of the American College of Cardiology  2015 66:1489-1496  DOI:10.1016/j.jacc.2015.08.006  PMID:26403346  PMCID:PMC4583658
  • Braenne, I., Civelek, M., Vilne, B., Di Narzo, A., Johnson, A. D., Zhao, Y., Reiz, B., Codoni, V., Webb, T. R., Asl, H. F., Hamby, S. E., Zeng, L., et al. Prediction of causal candidate genes in coronary artery disease loci Arteriosclerosis Thrombosis and Vascular Biology  2015 35:2207-2217  DOI:10.1161/atvbaha.115.306108  PMID:26293461  PMCID:PMC4583353
  • Harper, A. R., Nayee, S., Topol, E. J. Protective alleles and modifier variants in human health and disease Nature Reviews Genetics  2015 16:689-701  DOI:10.1038/nrg4017  PMID:26503796
  • Topol, E. J. The big medical data miss: challenges in establishing an open medical resource Nature Reviews Genetics  2015 16:253-254  DOI:10.1038/nrg3943  PMID:25882108
  • Steinhubl, S. R., Muse, E. D., Topol, E. J. The emerging field of mobile health Science Translational Medicine  2015 7  DOI:10.1126/scitranslmed.aaa3487  PMID:25877894  PMCID:PMC4748838
  • Teirstein, P. S., Topol, E. J. The role of maintenance of certification programs in governance and professionalism JAMA-Journal of the American Medical Association  2015 313:1809-1810  DOI:10.1001/jama.2015.3576  PMID:25965219  PMCID:PMC4751049
  • Lauer, M. S., Krumholz, H. M., Topol, E. J. Time for a prepublication culture in clinical research? Lancet  2015 386:2447-2449  DOI:10.1016/S0140-6736(15)01177-0  PMID:26738703  PMCID:PMC5082701
  • Kish, L. J., Topol, E. J. Unpatients-why patients should own their medical data Nature Biotechnology  2015 33:921-924  PMID:26348958
  • Shen, G. Q., Girelli, D., Li, L., Rao, S., Archacki, S., Olivieri, O., Martinelli, N., Park, J. E., Chen, Q., Topol, E. J., Wang, Q. K. A novel molecular diagnostic marker for familial and early-onset coronary artery disease and myocardial infarction in the LRP8 gene Circulation-Cardiovascular Genetics  2014 7:514-520  DOI:10.1161/circgenetics.113.000321  PMID:24867879  PMCID:PMC4140990
  • Khan, H. A., Wineinger, N. E., Uddin, P. Q., Mehta, H. S., Rubenson, D. S., Topol, E. J. Can hospital rounds with pocket ultrasound by cardiologists reduce standard echocardiography? American Journal of Medicine  2014 127:669.e1-669.e7  DOI:10.1016/j.amjmed.2014.03.015  PMID:24674919  PMCID:PMC4074438
  • Barrett, P. M., Komatireddy, R., Haaser, S., Topol, S., Sheard, J., Encinas, J., Fought, A. J., Topol, E. J. Comparison of 24-hour Holter monitoring with 14-day novel adhesive patch electrocardiographic monitoring American Journal of Medicine  2014 127:95.e11  DOI:10.1016/j.amjmed.2013.10.003  PMID:24384108  PMCID:PMC3882198
  • Bloss, C. S., Schork, N. J., Topol, E. J. Direct-to-consumer pharmacogenomic testing is associated with increased physician utilisation Journal of Medical Genetics  2014 51:83-89  DOI:10.1136/jmedgenet-2013-101909  PMID:24343916
  • Scott-Van Zeeland, A. A., Bloss, C. S., Tewhey, R., Bansal, V., Torkamani, A., Libiger, O., Duvvuri, V., Wineinger, N., Galvez, L., Darst, B. F., Smith, E. N., Carson, A., et al. Evidence for the role of EPHX2 gene variants in anorexia nervosa Molecular Psychiatry  2014 19:724-732  DOI:10.1038/mp.2013.91  PMID:23999524  PMCID:PMC3852189
  • Bethel, K., Luttgen, M. S., Damani, S., Kolatkar, A., Lamy, R., Sabouri-Ghomi, M., Topol, S., Topol, E. J., Kuhn, P. Fluid phase biopsy for detection and characterization of circulating endothelial cells in myocardial infarction Physical Biology  2014 11:016002  DOI:10.1088/1478-3975/11/1/016002  PMID:24406475  PMCID:PMC4143170
  • Chen, Y. Z., Friedman, J. R., Chen, D. H., Chan, G. C. K., Bloss, C. S., Hisama, F. M., Topol, S. E., Carson, A. R., Pham, P. H., Bonkowski, E. S., Scott, E. R., Lee, J. K., et al. Gain-of-function ADCY5 mutations in familial dyskinesia with facial myokymia Annals of Neurology  2014 75:542-549  DOI:10.1002/ana.24119  PMID:24700542  PMCID:PMC4457323
  • Gao, H., Li, L., Rao, S., Shen, G., Xi, Q., Chen, S., Zhang, Z., Wang, K., Ellis, S. G., Chen, Q., Topol, E. J., Wang, Q. K. Genome-wide linkage scan identifies two novel genetic loci for coronary artery disease: in GeneQuest families PLoS One  2014 9:e113935  DOI:10.1371/journal.pone.0113935  PMID:25485937  PMCID:PMC4259362
  • Steinhubl, S. R., Muse, E. D., Topol, E. J. Implementation of mobile health tools. Reply JAMA-Journal of the American Medical Association  2014 311:1448-1449  DOI:10.1001/jama.2014.1112  PMID:24715085
  • Topol, E. J. Individualized medicine from prewomb to tomb Cell  2014 157:241-253  DOI:10.1016/j.cell.2014.02.012  PMID:24679539  PMCID:PMC3995127
  • Walsh III, J. A., Topol, E. J., Steinhubl, S. R. Novel wireless devices for cardiac monitoring Circulation  2014 130:573-581  DOI:10.1161/circulationaha.114.009024  PMID:25114186  PMCID:PMC4135373
  • Tang, W. H. W., Topol, E. J., Fan, Y., Wu, Y., Cho, L., Stevenson, C., Ellis, S. G., Hazen, S. L. Prognostic value of estimated functional capacity incremental to cardiac biomarkers in stable cardiac patients Journal of the American Heart Association  2014 3:e000960  DOI:10.1161/jaha.114.000960
  • Steinhubl, S. R., Topol, E. J. RESPONSE: Time for the pager to enter retirement Journal of the American College of Cardiology  2014 64:2705-2705
  • Cruchaga, C., Karch, C. M., Jin, S. C., Benitez, B. A., Cai, Y., Guerreiro, R., Harari, O., Norton, J., Budde, J., Bertelsen, S., Jeng, A. T., Cooper, B., et al. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease Nature  2014 505:550-554  DOI:10.1038/nature12825  PMID:24336208  PMCID:PMC4050701
  • Goldberg, R., Kauffman, S., Topol, E. J. Study design and the drug development process JAMA-Journal of the American Medical Association  2014 311:2023-2023  DOI:10.1001/jama.2014.3826  PMID:24846044
  • Gaglani, S. M., Topol, E. J. iMedEd: the role of mobile health technologies in medical education Academic Medicine  2014 89:1207-1209  DOI:10.1097/acm.0000000000000361  PMID:24892404  PMCID:PMC4146691
  • Bloss, C. S., Wineinger, N. E., Darst, B. F., Schork, N. J., Topol, E. J. Impact of direct-to-consumer genomic testing at long term follow-up Journal of Medical Genetics  2013 393-400  DOI:10.1136/jmedgenet-2012-101207  PMID:23559530
  • Dunn, S. P., Steinhubl, S. R., Bauer, D., Charnigo, R. J., Berger, P. B., Topol, E. J. Impact of proton pump inhibitor therapy on the efficacy of clopidogrel in the CAPRIE and CREDO trials Journal of the American Heart Association  2013 2:e004564  DOI:10.1161/jaha.112.004564  PMID:23525436  PMCID:PMC3603228
  • Shen, G. Q., Girelli, D., Li, L., Olivieri, O., Martinelli, N., Chen, Q., Topol, E. J., Wang, Q. K. Multi-allelic haplotype association identifies novel information different from single-SNP analysis: A new protective haplotype in the LRP8 gene is against familial and early-onset CAD and MI Gene  2013 521:78-81  DOI:10.1016/j.gene.2013.03.022  PMID:23524007  PMCID:PMC3919654
  • Darst, B. F., Madlensky, L., Schork, N. J., Topol, E. J., Bloss, C. S. Perceptions of genetic counseling services in direct-to-consumer personal genomic testing Clinical Genetics  2013 84:335-339  DOI:10.1111/cge.12166  PMID:23590221
  • Goetz, L., Bethel, K., Topol, E. J. Rebooting cancer tissue handling in the sequencing era: Toward routine use of frozen tumor tissue JAMA-Journal of the American Medical Association  2013 309:37-38  PMID:23280221
  • Firstenberg, M. S., Dyke, C. M., Angiolillo, D. J., Ramaiahm, C., Price, M., Brtko, M., Welsby, I., Chandna, H., Holmes, D. R., Voeltz, M., Tummala, P., Hutyra, M., et al. Safety and efficacy of cangrelor, an intravenous, short-acting platelet inhibitor in patients requiring coronary artery bypass surgery Heart Surgery Forum  2013 16:E60-E69  DOI:10.1532/hsf98.20121103  PMID:23625478
  • Barrett, P. M., Topol, E. J. The fibrillin-1 gene: Unlocking new therapeutic pathways in cardiovascular disease Heart  2013 99:83-90  DOI:10.1136/heartjnl-2012-301840  PMID:22942299
  • Good, C. W., Steinhubl, S. R., Brennan, D. M., Lincoff, A. M., Topol, E. J., Berger, P. B. Is there a clinically significant interaction between calcium channel antagonists and clopidogrel?: results from the Clopidogrel for the Reduction of Events During Observation (CREDO) trial Circulation-Cardiovascular Interventions  2012 5:77-81  DOI:10.1161/circinterventions.111.963405  PMID:22319066
  • Lansky, A., Elashoff, M. R., Ng, V., McPherson, J., Lazar, D., Kraus, W. E., Voros, S., Schwartz, R. S., Topol, E. J., Investigators, Predict A gender-specific blood-based gene expression score for assessing obstructive coronary artery disease in nondiabetic patients: Results of the personalized risk evaluation and diagnosis in the coronary tree (predict) trial American Heart Journal  2012 164:320-326  DOI:10.1016/j.ahj.2012.05.012  PMID:22980297
  • Bloss, C. S., Topol, E. J., Schork, N. J. Association of direct-to-consumer genome-wide disease risk estimates and self-reported disease Genetic Epidemiology  2012 36:66-70  DOI:10.1002/gepi.20664  PMID:22127769  PMCID:PMC3338895
  • Angiolillo, D. J., Firstenberg, M. S., Price, M. J., Tummala, P. E., Hutyra, M., Welsby, I. J., Voeltz, M. D., Chandna, H., Ramaiah, C., Brtko, M., Cannon, L., Dyke, C., et al. Bridging antiplatelet therapy with cangrelor in patients undergoing cardiac surgery a randomized controlled trial JAMA-Journal of the American Medical Association  2012 307:265-274  DOI:10.1001/jama.2011.2002  PMID:22253393  PMCID:PMC3774162
  • Damani, S., Bacconi, A., Libiger, O., Chourasia, A. H., Serry, R., Gollapudi, R., Goldberg, R., Rapeport, K., Haaser, S., Topol, S., Knowlton, S., Bethel, K., et al. Characterization of circulating endothelial cells in acute myocardial infarction Science Translational Medicine  2012 4:126ra33  DOI:10.1126/scitranslmed.3003451  PMID:22440735  PMCID:PMC3589570
  • Archacki, S. R., Angheloiu, G., Moravec, C. S., Liu, H., Topol, E. J., Wang, Q. K. Comparative gene expression analysis between coronary arteries and internal mammary arteries identifies a role for the tes gene in endothelial cell functions relevant to coronary artery disease Human Molecular Genetics  2012 21:1364-1373  DOI:10.1093/hmg/ddr574  PMID:22156939
  • Mehta, R. H., Stebbins, A. S., Lopes, R. D., Califf, R. M., Pieper, K. S., Armstrong, P. W., Van de Werf, F., Hochman, J. S., White, H. D., Topol, E. J., Alexander, J. H., Granger, C. B. Comparison of incidence of bleeding and mortality of men versus women with st-elevation myocardial infarction treated with fibrinolysis American Journal of Cardiology  2012 109:320-326  DOI:10.1016/j.amjcard.2011.09.012  PMID:22078221
  • Barrett, P. M., Alagely, A., Topol, E. J. Cystic fibrosis in an era of genomically guided therapy Human Molecular Genetics  2012 21:R66-R71  DOI:10.1093/hmg/dds345  PMID:22914736
  • Geeganage, C. M., Diener, H. C., Algra, A., Chen, C., Topol, E. J., Dengler, R., Markus, H. S., Bath, M. W., Bath, P. M. W., Acute Antiplatelet Stroke, Trialist Dual or mono antiplatelet therapy for patients with acute ischemic stroke or transient ischemic attack: Systematic review and meta-analysis of randomized controlled trials Stroke  2012 43:1058-66  DOI:10.1161/strokeaha.111.637686  PMID:22282894
  • Tewhey, R., Cannavino, C. R., Leake, J. A. D., Bansal, V., Topol, E. J., Torkamani, A., Bradley, J. S., Schork, N. J. Genetic structure of community acquired methicillin-resistant Staphylococcus aureus USA300 BMC Genomics  2012 13:508  DOI:10.1186/1471-2164-13-508  PMID:23009684  PMCID:PMC3598774
  • Murray, S. S., Smith, E. N., Villarasa, N., Nahey, T., Lande, J., Goldberg, H., Shaw, M., Rosenthal, L., Ramza, B., Alaeddini, J., Han, X. Q., Damani, S., et al. Genome-wide association of implantable cardioverter-defibrillator activation with life-threatening arrhythmias PLoS One  2012 7:e25387  DOI:10.1371/journal.pone.0025387  PMID:22247754  PMCID:PMC3256134
  • Price, M. J., Murray, S. S., Angiolillo, D. J., Lillie, E., Smith, E. N., Tisch, R. L., Schork, N. J., Teirstein, P. S., Topol, E. J., Investigators, Gift Influence of genetic polymorphisms on the effect of high-and standard-dose clopidogrel after percutaneous coronary intervention the gift (genotype information and functional testing) study Journal of the American College of Cardiology  2012 59:1928-1937  DOI:10.1016/j.jacc.2011.11.068  PMID:22624833
  • Good, C. W., Steinhubl, S. R., Brennan, D. M., Lincoff, A. M., Topol, E. J., Berger, P. B. Is there a clinically significant interaction between calcium channel antagonists and clopidogrel? Results from the clopidogrel for the reduction of events during observation (credo) trial Circulation-Cardiovascular Interventions  2012 5:77-81  DOI:10.1161/circinterventions.111.963405  PMID:22319066
  • Komatireddy, R., Topol, E. J. Medicine unplugged: The future of laboratory medicine Clinical Chemistry  2012 58:1644-1647  DOI:10.1373/clinchem.2012.194324  PMID:23071365
  • Harper, A. R., Topol, E. J. Pharmacogenomics in clinical practice and drug development Nature Biotechnology  2012 30:1117-1124  DOI:10.1038/nbt.2424  PMID:23138311  PMCID:PMC3819119
  • Shamoon, H., Center, D., Davis, P., Tuchman, M., Ginsberg, H., Califf, R., Stephens, D., Mellman, T., Verbalis, J., Nadler, L., Shekhar, A., Ford, D., et al. Preparedness of the ctsa's structural and scientific assets to support the mission of the national center for advancing translational sciences (ncats) CTS-Clinical and Translational Science  2012 5:121-129  DOI:10.1111/j.1752-8062.2012.00401.x  PMID:22507116  PMCID:PMC3335735
  • Bhatt, D. L., Pare, G., Eikelboom, J. W., Simonsen, K. L., Emison, E. S., Fox, K. A. A., Steg, P. G., Montalescot, G., Bhakta, N., Hacke, W., Flather, M. D., Mak, K. H., et al. The relationship between cyp2c19 polymorphisms and ischaemic and bleeding outcomes in stable outpatients: The charisma genetics study European Heart Journal  2012 33:2143-2150  DOI:10.1093/eurheartj/ehs059  PMID:22450429
  • Rosenberg, S., Elashoff, M. R., Lieu, H. D., Brown, B. O., Kraus, W. E., Schwartz, R. S., Voros, S., Ellis, S. G., Waksman, R., McPherson, J. A., Lansky, A. J., Topol, E. J., et al. Whole blood gene expression testing for coronary artery disease in nondiabetic patients: Major adverse cardiovascular events and interventions in the predict trial Journal of Cardiovascular Translational Research  2012 5:366-374  DOI:10.1007/s12265-012-9353-z  PMID:22396313  PMCID:PMC3349850
  • Harismendy, O., Notani, D., Song, X. Y., Rahim, N. G., Tanasa, B., Heintzman, N., Ren, B., Fu, X. D., Topol, E. J., Rosenfeld, M. G., Frazer, K. A. 9p21 DNA variants associated with coronary artery disease impair interferon-gamma signalling response Nature  2011 470:264-268  DOI:10.1038/nature09753  PMID:21307941  PMCID:PMC3079517
  • Torkamani, A., Scott-Van Zeeland, A. A., Topol, E. J., Schork, N. J. Annotating individual human genomes Genomics  2011 98:233-241  DOI:10.1016/j.ygeno.2011.07.006  PMID:21839162  PMCID:PMC4074010
  • Mehta, R. H., O'Shea, J. C., Stebbins, A. L., Granger, C. B., Armstrong, P. W., White, H. D., Topol, E. J., Califf, R. M., Ohman, E. M. Association of mortality with years of education in patients with st-segment elevation myocardial infarction treated with fibrinolysis Journal of the American College of Cardiology  2011 57:138-146  DOI:10.1016/j.jacc.2010.09.021  PMID:21211684
  • Berger, J. S., Bhatt, D. L., Steg, P. G., Steinhubl, S. R., Montalescot, G., Shao, M. Y., Hacke, W., Fox, K. A., Berger, P. B., Topol, E. J., Lincoff, A. M., Investigators, Charisma Bleeding, mortality, and antiplatelet therapy: Results from the clopidogrel for high atherothrombotic risk and ischemic stabilization, management, and avoidance (charisma) trial American Heart Journal  2011 162:98-105  DOI:10.1016/j.ahj.2011.04.015  PMID:21742095
  • Elashoff, M. R., Wingrove, J. A., Beineke, P., Daniels, S. E., Tingley, W. G., Rosenberg, S., Voros, S., Kraus, W. E., Ginsburg, G. S., Schwartz, R. S., Ellis, S. G., Tahirkheli, N., et al. Development of a blood-based gene expression algorithm for assessment of obstructive coronary artery disease in non-diabetic patients BMC Medical Genomics  2011 4:26  DOI:10.1186/1755-8794-4-26  PMID:21443790  PMCID:PMC3072303
  • Bloss, C. S., Darst, B. F., Topol, E. J., Schork, N. J. Direct-to-consumer personalized genomic testing Human Molecular Genetics  2011 20:R132-R141  DOI:10.1093/hmg/ddr349  PMID:21828075  PMCID:PMC3179383
  • Chen, J., Shi, C. X., Mahoney, E. M., Dunn, E. S., Rinfret, S., Caro, J. J., O'Brien, J., El-Hadi, W., Bhatt, D. L., Topol, E. J., Cohen, D. J. Economic evaluation of clopidogrel plus aspirin for secondary prevention of cardiovascular events in canada for patients with established cardiovascular disease: Results from the charisma trial Canadian Journal of Cardiology  2011 27:222-231  DOI:10.1016/j.cjca.2010.12.021  PMID:21459271
  • Hankey, G. J., Johnston, S. C., Easton, J. D., Hacke, W., Mas, J. L., Brennan, D., Mak, K. H., Bhatt, D. L., Fox, K. A. A., Topol, E. J., Investigators, Charisma Trial Effect of clopidogrel plus asa vs. Asa early after tia and ischaemic stroke: A substudy of the charisma trial International Journal of Stroke  2011 6:3-9  DOI:10.1111/j.1747-4949.2010.00535.x  PMID:21205234
  • Bloss, C. S., Schork, N. J., Topol, E. J. Effect of direct-to-consumer genomewide profiling to assess disease risk New England Journal of Medicine  2011 364:524-534  DOI:10.1056/NEJMoa1011893  PMID:21226570  PMCID:PMC3786730
  • Damani, S. B., Topol, E. J. Emerging clinical applications in cardiovascular pharmacogenomics Wiley Interdisciplinary Reviews-Systems Biology and Medicine  2011 3:206-215  DOI:10.1002/wsbm.113  PMID:20730785  PMCID:PMC3000890
  • Damani, S. B., Topol, E. J. Emerging genomic applications in coronary artery disease JACC-Cardiovascular Interventions  2011 4:473-482  DOI:10.1016/j.jcin.2010.12.016  PMID:21596318
  • Bloss, C. S., Madlensky, L., Schork, N. J., Topol, E. J. Genomic information as a behavioral health intervention: Can it work? Personalized Medicine  2011 8:659-667  DOI:10.2217/pme.11.73  PMID:22199991  PMCID:PMC3244209
  • Weber, M., Bhatt, D. L., Brennan, D. M., Hankey, G. J., Steinhubl, S. R., Johnston, S. C., Montalescot, G., Mak, K. H., Fox, K. A. A., Easton, D. J., Topol, E. J., Hamm, C. W., et al. High-sensitivity c-reactive protein and clopidogrel treatment in patients at high risk of cardiovascular events: A substudy from the charisma trial Heart  2011 97:626-631  DOI:10.1136/hrt.2010.210419  PMID:21393433
  • Liebo, M. J., Israel, R. L., Lillie, E. O., Smith, M. R., Rubenson, D. S., Topol, E. J. Is pocket mobile echocardiography the next-generation stethoscope? A cross-sectional comparison of rapidly acquired images with standard transthoracic echocardiography Annals of Internal Medicine  2011 155:33-38  DOI:10.1059/0003-4819-155-1-201107050-00005  PMID:21727291
  • Lanktree, M. B., Guo, Y. R., Murtaza, M., Glessner, J. T., Bailey, S. D., Onland-Moret, N. C., Lettre, G., Ongen, H., Rajagopalan, R., Johnson, T., Shen, H., Nelson, C. P., et al. Meta-analysis of dense genecentric association studies reveals common and uncommon variants associated with height American Journal of Human Genetics  2011 88:6-18  DOI:10.1016/j.ajhg.2010.11.007  PMID:21194676  PMCID:PMC3014369
  • Price, M. J., Angiolillo, D. J., Teirstein, P. S., Lillie, E., Manoukian, S. V., Berger, P. B., Tanguay, J. F., Cannon, C. P., Topol, E. J. Platelet reactivity and cardiovascular outcomes after percutaneous coronary intervention a time-dependent analysis of the gauging responsiveness with a verifynow p2y12 assay: Impact on thrombosis and safety (gravitas) trial Circulation  2011 124:1132-1137  DOI:10.1161/circulationaha.111.029165  PMID:21875913
  • Price, M. J., Berger, P. B., Teirstein, P. S., Tanguay, J. F., Angiolillo, D. J., Spriggs, D., Puri, S., Robbins, M., Garratt, K. N., Bertrand, O. F., Stillablower, M. E., Aragon, J. R., et al. Standard- vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial JAMA-Journal of the American Medical Association  2011 305:1087-1095  DOI:10.1001/jama.2011.290  PMID:21406646
  • Tewhey, R., Bansal, V., Torkamani, A., Topol, E. J., Schork, N. J. The importance of phase information for human genomics Nature Reviews Genetics  2011 12:215-223  DOI:10.1038/nrg2950  PMID:21301473  PMCID:PMC3753045
  • Lillie, E. O., Patay, B., Diamant, J., Issell, B., Topol, E. J., Schork, N. J. The n-of-1 clinical trial: The ultimate strategy for individualizing medicine? Personalized Medicine  2011 8:161-173  DOI:10.2217/pme.11.7  PMID:21695041  PMCID:PMC3118090
  • Berger, P. B., Bhatt, D. L., Fuster, V., Steg, P. G., Fox, K. A. A., Shao, M., Brennan, D. M., Hacke, W., Montalescot, G., Steinhubl, S. R., Topol, E. J. Bleeding complications with dual antiplatelet therapy among patients with stable vascular disease or risk factors for vascular disease: results from the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance (CHARISMA) trial Circulation  2010 121:2575-2583  DOI:10.1161/circulationaha.109.895342  PMID:20516378
  • Bhatia, G., Bansal, V., Harismendy, O., Schork, N. J., Topol, E. J., Frazer, K., Bafna, V. A covering method for detecting genetic associations between rare variants and common phenotypes PLoS Computational Biology  2010 6:e1000954  DOI:10.1371/journal.pcbi.1000954  PMID:20976246  PMCID:PMC2954823
  • Yang, R., Li, L., Seidelmann, S. B., Shen, G. Q., Sharma, S., Rao, S. Q., Abdullah, K. G., MacKinlay, K. G., Elston, R. C., Chen, Q. Y., Topol, E. J., Wang, Q. K. A genome-wide linkage scan identifies multiple quantitative trait loci for hdl-cholesterol levels in families with premature cad and mi Journal of Lipid Research  2010 51:1442-1451  DOI:10.1194/jlr.M004325  PMID:20075193  PMCID:PMC3035507
  • Bansal, V., Harismendy, O., Tewhey, R., Murray, S. S., Schork, N. J., Topol, E. J., Frazer, K. A. Accurate detection and genotyping of snps utilizing population sequencing data Genome Research  2010 20:537-545  DOI:10.1101/gr.100040.109  PMID:20150320  PMCID:PMC2847757
  • Berger, P. B., Bhatt, D. L., Fuster, V., Steg, P. G., Fox, K. A. A., Shao, M. Y., Brennan, D. M., Hacke, W., Montalescot, G., Steinhubl, S. R., Topol, E. J., Investigators, Charisma Bleeding complications with dual antiplatelet therapy among patients with stable vascular disease or risk factors for vascular disease Circulation  2010 121:2575-2583  DOI:10.1161/circulationaha.109.895342  PMID:20516378
  • Ellinor, P. T., Lunetta, K. L., Glazer, N. L., Pfeufer, A., Alonso, A., Chung, M. K., Sinner, M. F., de Bakker, P. I. W., Mueller, M., Lubitz, S. A., Fox, E., Darbar, D., et al. Common variants in kcnn3 are associated with lone atrial fibrillation Nature Genetics  2010 42:240-244  DOI:10.1038/ng.537  PMID:20173747  PMCID:PMC2871387
  • Bloss, C. S., Ornowski, L., Silver, E., Cargill, M., Vanier, V., Schork, N. J., Topol, E. J. Consumer perceptions of direct-to-consumer personalized genomic risk assessments Genetics in Medicine  2010 12:556-566  DOI:10.1097/GIM.0b013e3181eb51c6  PMID:20717041
  • Hankey, G. J., Hacke, W., Easton, J. D., Johnston, S. C., Mas, J. L., Brennan, D. M., Bhatt, D. L., Fox, K. A. A., Topol, E. J., Investigators, Charisma Trial Effect of clopidogrel on the rate and functional severity of stroke among high vascular risk patients a prespecified substudy of the clopidogrel for high atherothrombotic risk and ischemic stabilization, management and avoidance (charisma) trial Stroke  2010 41:1679-1683  DOI:10.1161/strokeaha.110.586727  PMID:20595658
  • Montalescot, G., Ellis, S. G., de Belder, M. A., Janssens, L., Katz, O., Pluta, W., Ecollan, P., Tendera, M., van Boven, A. J., Widimsky, P., Andersen, H. R., Betriu, A., et al. Enoxaparin in primary and facilitated percutaneous coronary intervention a formal prospective nonrandomized substudy of the finesse trial (facilitated intervention with enhanced reperfusion speed to stop events) JACC-Cardiovascular Interventions  2010 3:203-212  DOI:10.1016/j.jcin.2009.11.012  PMID:20170878
  • Schork, N. J., Topol, E. J. Genotype-based risk and pharmacogenetic sampling in clinical trials Journal of Biopharmaceutical Statistics  2010 20:315-333  DOI:10.1080/10543400903572779  PMID:20309761  PMCID:PMC2892229
  • Tackett, A. H., Bailey, A. L., Foody, J. M., Miller, J. M., Apperson-Hansen, C., Ohman, E. M., Hochman, J. S., Karnash, S. L., Califf, R. M., Topol, E. J., Moliterno, D. J. Hormone replacement therapy among postmenopausal women presenting with acute myocardial infarction: Insights from the gusto-iii trial American Heart Journal  2010 160:678-684  DOI:10.1016/j.ahj.2010.06.030  PMID:20934562
  • Chen, W., Kahonen, M., Kettunen, J., Lehtimaki, T., Peltonen, L., Raitakari, O. T., Salem, R. M., Schork, N. J., Shaw, M., Srinivasan, S. R., Topol, E. J., Viikari, J. S., et al. Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study PLoS Genetics  2010 6:e1001094  DOI:10.1371/journal.pgen.1001094  PMID:20838585  PMCID:PMC2936521
  • Rosenberg, S., Elashoff, M. R., Beineke, P., Daniels, S. E., Wingrove, J. A., Tingley, W. G., Sager, P. T., Sehnert, A. J., Yau, M., Kraus, W. E., Newby, L. K., Schwartz, R. S., et al. Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients Annals of Internal Medicine  2010 153:425-434  DOI:10.7326/0003-4819-153-7-201010050-00005  PMID:20921541  PMCID:PMC3786733
  • Topol, E. J. Pharmacy benefit managers, pharmacies, and pharmacogenomic testing: Prescription for progress? Science Translational Medicine  2010 2:44cm22  DOI:10.1126/scitranslmed.3001067  PMID:20702854
  • Barker, C. M., Murray, S. S., Teirstein, P. S., Kandzari, D. E., Topol, E. J., Price, M. J. Pilot study of the antiplatelet effect of increased clopidogrel maintenance dosing and its relationship to cyp2c19 genotype in patients with high on-treatment reactivity JACC-Cardiovascular Interventions  2010 3:1001-1007  DOI:10.1016/j.jcin.2010.07.012  PMID:20965456
  • Harismendy, O., Bansal, V., Bhatia, G., Nakano, M., Scott, M., Wang, X. Y., Dib, C., Turlotte, E., Sipe, J. C., Murray, S. S., Deleuze, J. F., Bafna, V., et al. Population sequencing of two endocannabinoid metabolic genes identifies rare and common regulatory variants associated with extreme obesity and metabolite level Genome Biology  2010 11:R118  DOI:10.1186/gb-2010-11-11-r118  PMID:21118518  PMCID:PMC3156957
  • Topol, E. J., Bousser, M. G., Fox, K. A. A., Creager, M. A., Despres, J. P., Easton, J. D., Hamm, C. W., Montalescot, G., Steg, P. G., Pearson, T. A., Cohen, E., Gaudin, C., et al. Rimonabant for prevention of cardiovascular events (crescendo): A randomised, multicentre, placebo-controlled trial Lancet  2010 376:517-523  DOI:10.1016/s0140-6736(10)60935-x  PMID:20709233
  • Valgimigli, M., Biondi-Zoccai, G., Tebaldi, M., van't Hof, A. W., Campo, G., Hamm, C., ten Berg, J., Bolognese, L., Saia, F., Danzi, G. B., Briguori, C., Okmen, E., et al. Tirofiban as adjunctive therapy for acute coronary syndromes and percutaneous coronary intervention: A meta-analysis of randomized trials European Heart Journal  2010 31:35-49  DOI:10.1093/eurheartj/ehp376  PMID:19755402
  • Topol, E. J. Transforming medicine via digital innovation Science Translational Medicine  2010 2:16cm4  DOI:10.1126/scitranslmed.3000484  PMID:20371472  PMCID:PMC3756088
  • Ellis, S. G., Tendera, M., de Belder, M. A., van Boven, A. J., Widimsky, P., Andersen, H. R., Betriu, A., Savonitto, S., Adamus, J., Peruga, J. Z., Hamankiewicz, M., Pluta, W., et al. 1-year survival in a randomized trial of facilitated reperfusion results from the finesse (facilitated intervention with enhanced reperfusion speed to stop events) trial JACC-Cardiovascular Interventions  2009 2:909-916  DOI:10.1016/j.jcin.2009.07.009  PMID:19850248
  • Joyner, A. H., Roddey, J. C., Bloss, C. S., Bakken, T. E., Rimol, L. M., Melle, I., Agartz, I., Djurovic, S., Topol, E. J., Schork, N. J., Andreassen, O. A., Dale, A. M. A common MECP2 haplotype associates with reduced cortical surface area in humans in two independent populations Proceedings of the National Academy of Sciences of the United States of America  2009 106:15483-15488  DOI:10.1073/pnas.0901866106  PMID:19717458  PMCID:PMC2741277
  • Steinhubl, S. R., Bhatt, D. L., Brennan, D. M., Montalescot, G., Hankey, G. J., Eikelboom, J. W., Berger, P. B., Topol, E. J., Investigators, Charisma Aspirin to prevent cardiovascular disease: The association of aspirin dose and clopidogrel with thrombosis and bleeding Annals of Internal Medicine  2009 150:379-386  DOI:10.7326/0003-4819-150-6-200903170-00006  PMID:19293071
  • Herrmann, H. C., Lu, J. D., Brodie, B. R., Armstrong, P. W., Montalescot, G., Betriu, A., Neuman, F. J., Effron, M. B., Barnathan, E. S., Topol, E. J., Ellis, S. G., Investigators, Finesse Benefit of facilitated percutaneous coronary intervention in high-risk st-segment elevation myocardial infarction patients presenting to nonpercutaneous coronary intervention hospitals JACC-Cardiovascular Interventions  2009 2:917-924  DOI:10.1016/j.jcin.2009.06.018  PMID:19850249
  • Aronow, H. D., Steinhubl, S. R., Brennan, D. M., Berger, P. B., Topol, E. J., Investigators, Credo Bleeding risk associated with 1 year of dual antiplatelet therapy after percutaneous coronary intervention: Insights from the clopidogrel for the reduction of events during observation (credo) trial American Heart Journal  2009 157:369-374  DOI:10.1016/j.ahj.2008.09.011  PMID:19185647
  • Collet, J. P., Montalescot, G., Steg, P. G., Steinhubl, S. R., Fox, K. A. A., Hu, T. F., Johnston, S. C., Hamm, C. W., Bhatt, D. L., Topol, E. J. Clinical outcomes according to permanent discontinuation of clopidogrel or placebo in the charisma trial Archives of Cardiovascular Diseases  2009 102:485-496  DOI:10.1016/j.acvd.2009.03.012  PMID:19664568
  • Dasgupta, A., Steinhubl, S. R., Bhatt, D. L., Berger, P. B., Shao, M. Y., Mak, K. H., Fox, K. A. A., Montalescot, G., Weber, M. A., Haffner, S. M., Dimas, A. P., Steg, P. G., et al. Clinical outcomes of patients with diabetic nephropathy randomized to clopidogrel plus aspirin versus aspirin alone (a post hoc analysis of the clopidogrel for high atherothrombotic risk and ischemic stabilization, management, and avoidance [CHARISMA] trial) American Journal of Cardiology  2009 103:1359-1363  DOI:10.1016/j.amjcard.2009.01.342  PMID:19427428
  • Schork, N. J., Murray, S. S., Frazer, K. A., Topol, E. J. Common vs. Rare allele hypotheses for complex diseases Current Opinion in Genetics & Development  2009 19:212-219  DOI:10.1016/j.gde.2009.04.010  PMID:19481926  PMCID:PMC2914559
  • Chen, J., Bhatt, D. L., Dunn, E. S., Shi, C. X., Caro, J. J., Mahoney, E. M., Gabriel, S., Jackson, J. D., Topol, E. J., Cohen, D. J. Cost-effectiveness of clopidogrel plus aspirin versus aspirin alone for secondary prevention of cardiovascular events: Results from the charisma trial Value in Health  2009 12:872-879  DOI:10.1111/j.1524-4733.2009.00529.x  PMID:19490556
  • Robertson, J. O., Li, W., Silverstein, R. L., Topol, E. J., Smith, J. D. Deficiency of lrp8 in mice is associated with altered platelet function and prolonged time for in vivo thrombosis Thrombosis Research  2009 123:644-652  DOI:10.1016/j.thromres.2008.07.003  PMID:18706682  PMCID:PMC2661626
  • Tewhey, R., Nakano, M., Wang, X. Y., Pabon-Pena, C., Novak, B., Giuffre, A., Lin, E., Happe, S., Roberts, D. N., LeProust, E. M., Topol, E. J., Harismendy, O., et al. Enrichment of sequencing targets from the human genome by solution hybridization Genome Biology  2009 10:R116  DOI:10.1186/gb-2009-10-10-r116  PMID:19835619  PMCID:PMC2784331
  • Mak, K. H., Bhatt, D. L., Shao, M. Y., Hankey, G. J., Easton, J. D., Fox, K. A. A., Topol, E. J. Ethnic variation in adverse cardiovascular outcomes and bleeding complications in the clopidogrel for high atherothrombotic risk and ischemic stabilization, management, and avoidance (charisma) study American Heart Journal  2009 157:658-665  DOI:10.1016/j.ahj.2008.08.031  PMID:19332192
  • Price, M. J., Berger, P. B., Angiolillo, D. J., Teirstein, P. S., Tanguay, J. F., Kandzari, D. E., Cannon, C. P., Topol, E. J. Evaluation of individualized clopidogrel therapy after drug-eluting stent implantation in patients with high residual platelet reactivity: Design and rationale of the gravitas trial American Heart Journal  2009 157:818-824  DOI:10.1016/j.ahj.2009.02.012  PMID:19376306
  • Harismendy, O., Ng, P. C., Strausberg, R. L., Wang, X. Y., Stockwell, T. B., Beeson, K. Y., Schork, N. J., Murray, S. S., Topol, E. J., Levy, S., Frazer, K. A. Evaluation of next generation sequencing platforms for population targeted sequencing studies Genome Biology  2009 10:R32  DOI:10.1186/gb-2009-10-3-r32  PMID:19327155  PMCID:PMC2691003
  • Frazer, K. A., Murray, S. S., Schork, N. J., Topol, E. J. Human genetic variation and its contribution to complex traits Nature Reviews Genetics  2009 10:241-251  DOI:10.1038/nrg2554  PMID:19293820
  • Shishehbor, M. H., Madhwal, S., Rajagopal, V., Hsu, A., Kelly, P., Gurm, H. S., Kapadia, S. R., Lauer, M. S., Topol, E. J. Impact of blood transfusion on short- and long-term mortality in patients with st-segment elevation myocardial infarction JACC-Cardiovascular Interventions  2009 2:46-53  DOI:10.1016/j.jcin.2008.09.011  PMID:19463397
  • Tewhey, R., Warner, J. B., Nakano, M., Libby, B., Medkova, M., David, P. H., Kotsopoulos, S. K., Samuels, M. L., Hutchison, J. B., Larson, J. W., Topol, E. J., Weiner, M. P., et al. Microdroplet-based pcr enrichment for large-scale targeted sequencing Nature Biotechnology  2009 27:1025-1031  DOI:10.1038/nbt.1583  PMID:19881494  PMCID:PMC2779736
  • Cacoub, P. P., Bhatt, D. L., Steg, P. G., Topol, E. J., Creager, M. A., Investigators, Charisma Patients with peripheral arterial disease in the charisma trial European Heart Journal  2009 30:192-201  DOI:10.1093/eurheartj/ehn534  PMID:19136484
  • Dosh, K., Berger, P. B., Marso, S., van Lente, F., Brennan, D. M., Charnigo, R., Topol, E. J., Steinhubl, S. Relationship between baseline inflammatory markers, antiplatelet therapy, and adverse cardiac events after percutaneous coronary intervention an analysis from the clopidogrel for the reduction of events during observation trial Circulation-Cardiovascular Interventions  2009 2:503-512  DOI:10.1161/circinterventions.109.879312  PMID:20031767
  • Berger, J. S., Elliott, L., Gallup, D., Roe, M., Granger, C. B., Armstrong, P. W., Simes, R. J., White, H. D., Van de Werf, F., Topol, E. J., Hochman, J. S., Newby, L. K., et al. Sex differences in mortality following acute coronary syndromes JAMA-Journal of the American Medical Association  2009 302:874-882  DOI:10.1001/jama.2009.1227  PMID:19706861  PMCID:PMC2778841
  • Berger, J. S., Bhatt, D. L., Steinhubl, S. R., Shao, M. Y., Steg, P. G., Montalescot, G., Hacke, W., Fox, K. A., Lincoff, A. M., Topol, E. J., Berger, P. B., Investigators, Charisma Smoking, clopidogrel, and mortality in patients with established cardiovascular disease Circulation  2009 120:2337-2344  DOI:10.1161/circulationaha.109.866533  PMID:19933933  PMCID:PMC2814172
  • Van De Werf, F. J., Topol, E. J., Sobel, B. E. The impact of fibrinolytic therapy for st-segment-elevation acute myocardial infarction Journal of Thrombosis and Haemostasis  2009 7:14-20  DOI:10.1111/j.1538-7836.2008.03195.x  PMID:19090814
  • Mak, K. H., Bhatt, D. L., Shao, M., Haffner, S. M., Hamm, C. W., Hankey, G. J., Johnston, S. C., Montalescot, G., Steg, P. G., Steinhubl, S. R., Fox, K. A. A., Topol, E. J. The influence of body mass index on mortality and bleeding among patients with or at high-risk of atherothrombotic disease European Heart Journal  2009 30:857-865  DOI:10.1093/eurheartj/ehp037  PMID:19233855
  • Berger, J. S., Bhatt, D. L., Cannon, C. P., Chen, Z. M., Jiang, L. X., Jones, J. B., Mehta, S. R., Sabatine, M. S., Steinhubl, S. R., Topol, E. J., Berger, P. B. The relative efficacy and safety of clopidogrel in women and men a sex-specific collaborative meta-analysis Journal of the American College of Cardiology  2009 54:1935-1945  DOI:10.1016/j.jacc.2009.05.074  PMID:19909874
  • Elias, D. J., Topol, E. J. Warfarin pharmacogenomics: A big step forward for individualized medicine: enlightened dosing of warfarin European Journal of Human Genetics  2008 16:532-534  DOI:10.1038/sj.ejhg.5201945  PMID:18301451
  • Hart, R. G., Bhatt, D. L., Hacke, W., Fox, K. A. A., Hankey, G. J., Berger, P. B., Hu, T. F., Topol, E. J., Invest, Charisma Clopidogrel and aspirin versus aspirin alone for the prevention of stroke in patients with a history of atrial fibrillation: Subgroup analysis of the charisma randomized trial Cerebrovascular Diseases  2008 25:344-347  DOI:10.1159/000118380  PMID:18303254
  • Sabatine, M. S., Hamdalla, H. N., Mehta, S. R., Fox, K. A. A., Topol, E. J., Steinhubl, S. R., Cannon, C. P. Efficacy and safety of clopidogrel pretreatment before percutaneous coronary intervention with and without glycoprotein iib/iiia inhibitor use American Heart Journal  2008 155:910-917  DOI:10.1016/j.ahj.2007.11.020  PMID:18440341
  • Ellis, S. G., Tendera, M., de Belder, M. A., van Boven, A. J., Widimsky, P., Janssens, L., Andersen, H. R., Betriu, A., Savonitto, S., Adamus, J., Peruga, J. Z., Kosmider, M., et al. Facilitated pci in patients with st-elevation myocardial infarction New England Journal of Medicine  2008 358:2205-2217  DOI:10.1056/NEJMoa0706816  PMID:18499565
  • Abdullah, K. G., Li, L., Shen, G. Q., Hu, Y., Yang, Y., MacKinlay, K. G., Topol, E. J., Wang, Q. K. Four snps on chromosome 9p21 confer risk to premature, familial cad and mi in an american caucasian population (genequest) Annals of Human Genetics  2008 72:654-657  DOI:10.1111/j.1469-1809.2008.00454.x  PMID:18505420  PMCID:PMC2634771
  • Rahim, N. G., Harismendy, O., Topol, E. J., Frazer, K. A. Genetic determinants of phenotypic diversity in humans Genome Biology  2008 9:215  DOI:10.1186/gb-2008-9-4-215  PMID:18439327  PMCID:PMC2643926
  • Seidelmann, S. B., Li, L., Shen, G. Q., Topol, E. J., Wang, Q. K. Identification of a novel locus for triglyceride on chromosome 1p31-32 in families with premature cad and mi Journal of Lipid Research  2008 49:1034-1038  DOI:10.1194/jlr.M700576-JLR200  PMID:18245017  PMCID:PMC2311437
  • Eikelboom, J. W., Hankey, G. J., Thom, J., Bhatt, D. L., Steg, P. G., Montalescot, G., Johnston, S. C., Steinhubl, S. R., Mak, K. H., Easton, J. D., Hamm, C., Hu, T. F., et al. Incomplete inhibition of thromboxane biosynthesis by acetylsalicylic acid determinants and effect on cardiovascular risk Circulation  2008 118:1705-1712  DOI:10.1161/circulationaha.108.768283  PMID:18838564
  • Inrig, J. K., Patel, U. D., Briley, L. P., She, L. L., Gillespie, B. S., Easton, J. D., Topol, E. J., Szczech, L. A. Mortality, kidney disease and cardiac procedures following acute coronary syndrome Nephrology Dialysis Transplantation  2008 23:934-940  DOI:10.1093/ndt/gfm689  PMID:17984102
  • Torkamani, A., Topol, E. J., Schork, N. J. Pathway analysis of seven common diseases assessed by genome-wide association Genomics  2008 92:265-272  DOI:10.1016/j.ygeno.2008.07.011  PMID:18722519  PMCID:PMC2602835
  • Aronow, H. D., Califf, R. M., Harrington, R. A., Vallee, M., Graffagnino, C., Shuaib, A., Fitzgerald, D. J., Easton, J. D., Van de Werf, F., Diener, H. C., Ferguson, J., Koudstaal, P. J., et al. Relation between aspirin dose, all-cause mortality, and bleeding in patients with recent cerebrovascular or coronary ischemic events (from the bravo trial) American Journal of Cardiology  2008 102:1285-1290  DOI:10.1016/j.amjcard.2008.07.019  PMID:18993142
  • Aronow, H. D., Lincoff, A. M., Quinn, M. J., McRae, A. T., Gurm, H. S., Houghtaling, P. L., Granger, C. B., Harrington, R. A., de Werf, F. V., Topol, E. J., Lauer, M. S., Gusto, Ilb Relation between previous lipid-lowering therapy and infaret size (creatine kinase-mb level) in patients presenting with acute myocardial infarction American Journal of Cardiology  2008 102:1119-1124  DOI:10.1016/j.amjcard.2008.06.032  PMID:18940276
  • Bhattacharyya, T., Nicholls, S. J., Topol, E. J., Zhang, R. L., Yang, X., Schmitt, D., Fu, X. M., Shao, M. Y., Brennan, D. M., Ellis, S. G., Brennan, M. L., Allayee, H., et al. Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk JAMA-Journal of the American Medical Association  2008 299:1265-1276  DOI:10.1001/jama.299.11.1265  PMID:18349088  PMCID:PMC3014051
  • Best, P. J. M., Steinhubl, S. R., Berger, P. B., Dasgupta, A., Brennan, D. M., Szczech, L. A., Califf, R. M., Topol, E. J., Investigators, Credo The efficacy and safety of short- and long-term dual antiplatelet therapy in patients with mild or moderate chronic kidney disease: Results from the clopidogrel for the reduction of events during observation (credo) trial American Heart Journal  2008 155:687-693  DOI:10.1016/j.ahj.2007.10.046  PMID:18371477
  • Musunuru, K., Kral, B. G., Blumenthal, R. S., Fuster, V., Campbell, C. Y., Gluckman, T. J., Lange, R. A., Topol, E. J., Willerson, J. T., Desai, M. Y., Davidson, M. H., Mora, S. The use of high-sensitivity assays for c-reactive protein in clinical practice Nature Clinical Practice Cardiovascular Medicine  2008 5:621-635  DOI:10.1038/ncpcardio1322  PMID:18711404  PMCID:PMC2639398
  • Jozic, J., Orford, J., Steinhubl, S., Berger, P., Hsu, A., Topol, E. Timing and correlates of very early major adverse clinical events following percutaneous coronary intervention Journal of Invasive Cardiology  2008 20:113-118  PMID:18316826
  • Bhatt, D. L., Chew, D. P., Grines, C., Mukherjee, D., Leesar, M., Gilchrist, I. C., Corbelli, J. C., Blankenship, J. C., Eres, A., Steinhubl, S., Tan, W. A., Resar, J. R., et al. Interventional cardiology - Peroxisome proliferator-activated receptor gamma agonists for the Prevention of Adverse events following percutaneous coronary Revascularization - results of the PPAR Study American Heart Journal  2007 154:137-143  DOI:10.1016/j.ahj.2007.03.029
  • Luke, M. M., Kane, J. P., Liu, D. M., Rowland, C. M., Shiffman, D., Cassano, J., Catanese, J. J., Pullinger, C. R., Leong, D. U., Arellano, A. R., Tong, C. H., Movsesyan, I., et al. A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery disease Arteriosclerosis, Thrombosis, and Vascular Biology  2007 27:2030-2036  DOI:10.1161/atvbaha.107.141291  PMID:17569884
  • Wang, T. H., Bhatt, D. L., Fox, K. A. A., Steinhubl, S. R., Brennan, D. M., Hacke, W., Mak, K. H., Pearson, T. A., Boden, W. E., Steg, P. G., Flather, M. D., Montalescot, G., et al. An analysis of mortality rates with dual-antiplatelet therapy in the primary prevention population of the charisma trial European Heart Journal  2007 28:2200-2207  DOI:10.1093/eurheartj/ehm274  PMID:17673448
  • Shen, G. Q., Li, L., Girelli, D., Seidelmann, S. B., Rao, S., Fan, C., Park, J. E., Xi, Q., Li, J., Hu, Y., Olivieri, O., Marchant, K., et al. An lrp8 variant is associated with familial and premature coronary artery disease and myocardial infarction American Journal of Human Genetics  2007 81:780-791  DOI:10.1086/521581  PMID:17847002  PMCID:PMC2227927
  • Luo, A. K., Jefferson, B. K., Garcia, M. J., Ginsburg, G. S., Topol, E. J. Challenges in the phenotypic characterisation of patients in genetic studies of coronary artery disease Journal of Medical Genetics  2007 44:161-165  DOI:10.1136/jmg.2006.045732  PMID:17158593  PMCID:PMC2598022
  • Mahaffey, K. W., Roe, M. T., Kilaru, R., Alexander, J. H., Van de Werf, F., Califf, R. M., Simoons, M. L., Topol, E. J., Harrington, R. A. Creatine kinase-mb elevation after coronary artery bypass grafting surgery in patients with non-st-segment elevation acute coronary syndromes predict worse outcomes: Results from four large clinical trials European Heart Journal  2007 28:425-432  DOI:10.1093/eurheartj/ehl483  PMID:17267458
  • Damani, S. B., Topol, E. J. Future use of genomics in coronary artery disease Journal of the American College of Cardiology  2007 50:1933-1940  DOI:10.1016/j.jacc.2007.07.062  PMID:17996556
  • Reynolds, H. R., Farkouh, M. E., Lincoff, A. M., Hsu, A., Swahn, E., Sadowski, Z. P., White, J. A., Topol, E. J., Hochman, J. S., Investigators, Gusto V. Impact of female sex on death and bleeding after fibrinolytic treatment of myocardial infarction in gusto v Archives of Internal Medicine  2007 167:2054-2060  DOI:10.1001/archinte.167.19.2054  PMID:17954798
  • Mak, K. H., Ma, S., Heng, D., Tan, C. E., Tai, E. S., Topol, E. J., Chew, S. K. Impact of sex, metabolic syndrome, and diabetes mellitus on cardiovascular events American Journal of Cardiology  2007 100:227-233  DOI:10.1016/j.amjcard.2007.02.090  PMID:17631075
  • Shishehbor, M. H., Lauer, M. S., Singh, I. M., Chew, D. P., Karha, J., Brener, S. J., Moliterno, D. J., Ellis, S. G., Topol, E. J., Bhatt, D. L. In unstable angina or non-st-segment acute coronary syndrome, should patients with multivessel coronary artery disease undergo multivessel or culprit-only stenting? Journal of the American College of Cardiology  2007 49:849-854  DOI:10.1016/j.jacc.2006.10.054  PMID:17320742
  • Bhatt, D. L., Chew, D. P., Grines, C., Mukherjee, D., Leesar, M., Gilchrist, I. C., Corbelli, J. C., Blankenship, J. C., Eres, A., Steinhubl, S., Tan, W. A., Resar, J. R., et al. Interventional cardiology - peroxisome proliferator-activated receptor gamma agonists for the prevention of adverse events following percutaneous coronary revascularization - results of the ppar study American Heart Journal  2007 154:137-143  DOI:10.1016/j.ahj.2007.03.029  PMID:17584566
  • Saw, J., Brennan, D. M., Steinhubl, S. R., Bhatt, D. L., Mak, K. H., Fox, K., Topol, E. J., Investigators, Charisma Lack of evidence of a clopidogrel-statin interaction in the charisma trial Journal of the American College of Cardiology  2007 50:291-295  DOI:10.1016/j.jacc.2007.01.097  PMID:17659194
  • Singh, M., White, J., Hasdai, D., Hodgson, P. K., Berger, P. B., Topol, E. J., Calif, R. M., Holmes, D. R. Long-term outcome and its predictors among patients with st-segment elevation myocardial infarction complicated by shock: Insights from the gusto-i trial Journal of the American College of Cardiology  2007 50:1752-1758  DOI:10.1016/j.jacc.2007.04.101  PMID:17964038
  • Bhatt, D. L., Flather, M. D., Hacke, W., Berger, P. B., Black, H. R., Boden, W. E., Cacoub, P., Cohen, E. A., Creager, M. A., Easton, J. D., Hamm, C. W., Hankey, G. J., et al. Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the charisma trial Journal of the American College of Cardiology  2007 49:1982-1988  DOI:10.1016/j.jacc.2007.03.025  PMID:17498584
  • Feit, F., Voeltz, M. D., Attubato, M. J., Lincoff, A. M., Chew, D. P., Bittl, J. A., Topol, E. J., Manoukian, S. V. Predictors and impact of major hemorrhage on mortality following percutaneous coronary intervention from the replace-2 trial American Journal of Cardiology  2007 100:1364-1369  DOI:10.1016/j.amjcard.2007.06.026  PMID:17950791
  • Wang, Z., Nicholls, S. J., Rodriguez, E. R., Kummu, O., Horkko, S., Barnard, J., Reynolds, W. F., Topol, E. J., DiDonato, J. A., Hazen, S. L. Protein carbamylation links inflammation, smoking, uremia and atherogenesis Nature Medicine  2007 13:1176-1184  DOI:10.1038/nm1637  PMID:17828273
  • Anwaruddin, S., Askari, A. T., Topol, E. J. Redefining risk in acute coronary syndromes using molecular medicine Journal of the American College of Cardiology  2007 49:279-289  DOI:10.1016/j.jacc.2006.08.051  PMID:17239708
  • Inrig, J. K., Gillespie, B. S., Patel, U. D., Briley, L. P., She, L., Easton, J. D., Topol, E., Szczech, L. A. Risk for cardiovascular outcomes among subjects with atherosclerotic cardiovascular disease and greater-than-normal estimated glomerular filtration rate Clinical Journal of the American Society of Nephrology  2007 2:1215-1222  DOI:10.2215/cjn.00930207  PMID:17942781
  • Tang, W. H. W., Steinhubl, S. R., Van Lente, F., Brennan, D., McErlean, E., Maroo, A., Francis, G. S., Topol, E. J. Risk stratification for patients undergoing nonurgent percutaneous coronary intervention using n-terminal pro-b-type natriuretic peptide: A clopidogrel for the reduction of events during observation (credo) substudy American Heart Journal  2007 153:36-41  DOI:10.1016/j.ahj.2006.10.011  PMID:17174634
  • Mehta, R. H., Califf, R. M., Garg, J., White, H. D., Van de Werf, F., Armstrong, P. W., Pieper, K. S., Topol, E. J., Granger, C. B. The impact of anthropomorphic indices on clinical outcomes in patients with acute st-elevation myocardial infarction European Heart Journal  2007 28:415-424  DOI:10.1093/eurheartj/ehl329  PMID:17040928
  • Stenina, O. I., Topol, E. J., Plow, E. F. Thrombospondins, their polymorphisms, and cardiovascular disease Arteriosclerosis, Thrombosis, and Vascular Biology  2007 27:1886-1894  DOI:10.1161/atvbaha.107.141713  PMID:17569883
  • Helgadottir, A., Manolescu, A., Helgason, A., Thorleifsson, G., Thorsteinsdottir, U., Gudbjartsson, D. F., Gretarsdottir, S., Magnusson, K. P., Gudmundsson, G., Hicks, A., Jonsson, T., Grant, S. F. A., et al. A variant of the gene encoding leukotriene a4 hydrolase confers ethnicity-specific risk of myocardial infarction Nature Genetics  2006 38:68-74  DOI:10.1038/ng1692  PMID:16282974
  • Blankenship, J. C., Haldis, T., Feit, F., Hu, T. F., Kleiman, N. S., Topol, E. J., Lincoff, A. M., Investigators, Replace- Angiographic adverse events, creatine kinase-mb elevation, and ischemic end points complicating percutaneous coronary intervention (a replace-2 substudy) American Journal of Cardiology  2006 97:1591-1596  DOI:10.1016/j.amjcard.2005.12.050  PMID:16728220
  • Wang, T. H., Bhatt, D. L., Topol, E. J. Aspirin and clopidogrel resistance: An emerging clinical entity European Heart Journal  2006 27:647-654  DOI:10.1093/eurheartj/ehi684  PMID:16364973
  • Chew, D. P., Bhatt, D. L., Lincoff, A. M., Wolski, K., Topol, E. J. Clinical end point definitions after percutaneous coronary intervention and their relationship to late mortality: An assessment by attributable risk Heart  2006 92:945-950  DOI:10.1136/hrt.2005.078758  PMID:16387822  PMCID:PMC1860685
  • Bhatt, D. L., Fox, K. A. A., Hacke, W., Berger, P. B., Black, H. R., Boden, W. E., Cacoub, P., Cohen, E. A., Creager, M. A., Easton, J. D., Flather, M. D., Haffner, S. M., et al. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events New England Journal of Medicine  2006 354:1706-1717  DOI:10.1056/NEJMoa060989  PMID:16531616
  • Kao, J., Lincoff, A. M., Topol, E. J., Madrid, A., Price, M. J., Sawhney, N., Teirstein, P. S. Direct thrombin inhibition appears to be a safe and effective anticoagulant for percutaneous bypass graft interventions Catheterization and Cardiovascular Interventions  2006 68:352-356  DOI:10.1002/ccd.20735  PMID:16892428
  • Galla, J. M., Mahaffey, K. W., Sapp, S. K., Alexander, J. H., Roe, M. T., Ohman, E. M., Granger, C. B., Armstrong, P. W., Harrington, R. A., White, H. D., Simoons, M. L., Newby, L. K., et al. Elevated creatine kinase-mb with normal creatine kinase predicts worse outcomes in patients with acute coronary syndromes: Results from 4 large clinical trials American Heart Journal  2006 151:16-24  DOI:10.1016/j.ahj.2005.01.045  PMID:16368286
  • Mukherjee, D., Topol, E. J., Moliterno, D. J., Brennan, D. M., Ziada, K., Cho, L., Steinhubl, S. R., Investigators, Credo Extracardiac vascular disease and effectiveness of sustained clopidogrel treatment Heart  2006 92:49-51  DOI:10.1136/hrt.2005.064501  PMID:15845611  PMCID:PMC1860989
  • Shiffman, D., Rowland, C. M., Louie, J. Z., Luke, M. M., Bare, L. A., Bolonick, J. I., Young, B. A., Catanese, J. J., Stiggins, C. F., Pullinger, C. R., Topol, E. J., Malloy, M. J., et al. Gene variants of vamp8 and hnrpul1 are associated with early-onset myocardial infarction Arteriosclerosis, Thrombosis, and Vascular Biology  2006 26:1613-1618  DOI:10.1161/01.ATV.0000226543.77214.e4  PMID:16690874
  • Topol, E. J., Smith, J., Plow, E. F., Wang, Q. K. Genetic susceptibility to myocardial infarction and coronary artery disease Human Molecular Genetics  2006 15:R117-R123  DOI:10.1093/hmg/ddl183  PMID:16987874
  • Ellis, S. G., Penn, M. S., Bolwell, B., Garcia, M., Chacko, M., Wang, T., Brezina, K. J., McConnell, G., Topol, E. J. Granulocyte colony stimulating factor in patients with large acute myocardial infarction: Results of a pilot dose-escalation randomized trial American Heart Journal  2006 152:1051.e9  DOI:10.1016/j.ahj.2006.09.003
  • Hewson, M. G., Copeland, H. L., Mascha, E., Arrigain, S., Topol, E., Fox, J. E. B. Integrative medicine: Implementation and evaluation of a professional development program using experiential learning and conceptual change teaching approaches Patient Education and Counseling  2006 62:5-12  DOI:10.1016/j.pec.2006.03.005  PMID:16766243
  • Chacko, M., Lincoff, A. M., Wolski, K. E., Cohen, D. J., Bittl, J. A., Lansky, A. J., Tsuchiya, Y., Betriu, A., Yen, M. H., Chew, D. P., Cho, L., Topol, E. J. Ischemic and bleeding outcomes in women treated with bivalirudin during percutaneous coronary intervention: a subgroup analysis of the Randomized Evaluation in PCI Linking Angiomax to Reduced Clinical Events (REPLACE)-2 trial American Heart Journal  2006 151:1032.e1-1032.e7  DOI:10.1016/j.ahj.2006.02.012  PMID:16644331
  • Salpeter, S. R., Gregor, P., Ormiston, T. M., Whitlock, R., Raina, P., Thabane, L., Topol, E. J. Meta-analysis: Cardiovascular events associated with nonsteroidal anti-inflammatory drugs American Journal of Medicine  2006 119:552-559  DOI:10.1016/j.amjmed.2005.10.056  PMID:16828623
  • Steinhubl, S. R., Berger, P. B., Brennan, D. A., Topol, E. J., Investigators, Credo Optimal timing for pre-treatment with before percutaneous the initiation of 300 mg clopidogrel coronary intervention Journal of the American College of Cardiology  2006 47:939-943  DOI:10.1016/j.jacc.2005.10.047  PMID:16516075
  • Shishelibor, M. H., Topol, E. J., Mukherjee, D., Hu, T. F., Cohen, D. J., Stone, G. W., McClure, R., Roffi, M., Moliterno, D. J., TARGET Investigators Outcome of multivessel coronary intervention in the contemporary percutaneous revascularization era American Journal of Cardiology  2006 97:1585-1590  DOI:10.1016/j.amjcard.2005.12.049  PMID:16728219
  • Rajagopal, V., Lincoff, A. M., Cohen, D. J., Gurm, H. S., Hu, T. F., Desmet, W. J., Kleiman, N. S., Bittl, J. A., Feit, F., Topol, E. J. Outcomes of patients with acute coronary syndromes who are treated with bivalirudin during percutaneous coronary intervention: An analysis from the randomized evaluation in pci linking angiomax to reduced clinical events (replace-2) trial American Heart Journal  2006 152:149-154  DOI:10.1016/j.ahj.2005.09.007  PMID:16824845
  • Wang, K., Zhou, Z. M., Zhang, M., Fan, L. M., Forudi, F., Zhou, X. R., Qu, W., Lincoff, A. M., Schmidt, A. M., Topol, E. J., Penn, M. S. Peroxisome proliferator-activated receptor gamma down-regulates receptor for advanced glycation end products and inhibits smooth muscle cell proliferation in a diabetic and nondiabetic rat carotid artery injury model Journal of Pharmacology and Experimental Therapeutics  2006 317:37-43  DOI:10.1124/jpet.105.095125  PMID:16368901
  • Robertson, J. O., Lincoff, A. M., Wolski, K., Topol, E. J. Planned versus provisional use of glycoprotein iib/iiia inhibitors in smokers undergoing percutaneous' coronary intervention American Journal of Cardiology  2006 97:1679-1684  DOI:10.1016/j.amjcard.2005.12.066  PMID:16765113
  • Brener, S. J., Lytle, B. W., Casserly, I. P., Ellis, S. G., Topol, E. J., Lauer, M. S. Predictors of revascularization method and long-term outcome of percutaneous coronary intervention or repeat coronary bypass surgery in patients with multivessel coronary disease and previous coronary bypass surgery European Heart Journal  2006 27:413-418  DOI:10.1093/eurheartj/ehi646  PMID:16272211
  • Karha, J., Topol, E. J. Primary percutaneous coronary intervention vs. Fibrinolytic therapy for acute st-elevation myocardial infarction in the elderly American Journal of Geriatric Cardiology  2006 15:19-21  DOI:10.1111/j.1076-7460.2006.05290.x  PMID:16415642
  • Exaire, J. E., Butman, S. M., Ebrahimi, R., Kleiman, N. S., Harrington, R. A., Schweiger, M. J., Bittl, J. A., Wolski, K., Topol, E. J., Lincoff, A. M., Invest, Replace- Provisional glycoprotein iib/iiia blockade in a randomized investigation of bivalirudin versus heparin plus planned glycoprotein iib/iiia inhibition during percutaneous coronary intervention: Predictors and outcome in the randomized evaluation in percutaneous coronary intervention linking angiomax to reduced clinical events (replace)-2 trial American Heart Journal  2006 152:157-162  DOI:10.1016/j.ahj.2005.09.004  PMID:16824849
  • Bushnell, C. D., Griffin, J., Newby, L. K., Goldstein, L. B., Mahaffey, K. W., Graffagnino, C. A., Harrington, R. A., White, H. D., Simes, R. J., Califf, R. M., Topol, E. J., Easton, J. D. Statin use and sex-specific stroke outcomes in patients with vascular disease Stroke  2006 37:1427-1431  DOI:10.1161/01.STR.0000221315.60282.ca  PMID:16645137
  • Shishehbor, M. H., Zhang, R. L., Medina, H., Brennan, M. L., Brennan, D. M., Ellis, S. G., Topol, E. J., Hazen, S. L. Systemic elevations of free radical oxidation products of arachidonic acid are associated with angiographic evidence of coronary artery disease Free Radical Biology and Medicine  2006 41:1678-1683  DOI:10.1016/j.freeradbiomed.2006.09.001  PMID:17145556  PMCID:PMC1945055
  • Topol, E. J. The genetics of heart attack Heart  2006 92:855-861  DOI:10.1136/hrt.2005.060202  PMID:16698843  PMCID:PMC1860653
  • Saw, J., Bhatt, D. L., Moliterno, D. J., Brener, S. J., Steinhubl, S. R., Lincoff, A. M., Tcheng, J. E., Harrington, R. A., Simoons, M., Hu, T., Sheikh, M. A., Kereiakes, D. J., et al. The influence of peripheral arterial disease on outcomes - a pooled analysis of mortality in eight large randomized percutaneous coronary intervention trials Journal of the American College of Cardiology  2006 48:1567-1572  DOI:10.1016/j.jacc.2006.03.067  PMID:17045889
  • Goodman, S. G., Fu, Y. L., Langer, A., Barr, A., Tan, M., Wagner, G. S., Barbagelata, A., Sgarbossa, E. B., Birnbaum, Y., Granger, C. B., Califf, R. M., Van de Werf, F., et al. The prognostic value of the admission and predischarge electrocardiogram in acute coronary syndromes: The gusto-iib ecg core laboratory experience American Heart Journal  2006 152:277-284  DOI:10.1016/j.ahj.2005.12.022  PMID:16875908
  • Martin, J. L., Jia, G., Martin, S. S., Shapiro, T. A., Herrmann, H. C., DiBattiste, P. M., Topol, E. J., Moliterno, D. J. The relationship of obesity to ischemic outcomes following coronary stent placement in contemporary practice Catheterization and Cardiovascular Interventions  2006 67:563-570  DOI:10.1002/ccd.20622  PMID:16532491
  • Topol, E. J. A contemporary assessment of low-molecular-weight heparin for the treatment of acute coronary syndromes: Factoring in new trials and meta-analysis data American Heart Journal  2005 149:S100-S106  DOI:10.1016/j.ahj.2005.02.024  PMID:16124950
  • Bhatt, D. L., Fox, K. A., Hacke, W., Berger, P. B., Black, H. R., Boden, W. E., Cacoub, P., Cohen, E. A., Creager, M. A., Easton, J. D., Flather, M. D., Haffner, S. M., et al. A global view of atherothrombosis: baseline characteristics in the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance (CHARISMA) trial American Heart Journal  2005 150:401.e1-401.e7  DOI:10.1016/j.ahj.2005.03.017  PMID:16169314
  • Li, L. B., Jiang, W., Li, X., Moser, K. L., Guo, Z., Du, L., Wang, Q. J., Topol, E. J., Wang, Q., Rao, S. A robust hybrid between genetic algorithm and support vector machine for extracting an optimal feature gene subset Genomics  2005 85:16-23  DOI:10.1016/j.ygeno.2004.09.007  PMID:15607418
  • De Luca, G., Suryapranata, H., Stone, G. W., Antoniucci, D., Tcheng, J. E., Neumann, F. J., Van de Werf, F., Antman, E. M., Topol, E. J. Abciximab as adjunctive therapy to reperfusion in acute st-segment elevation myocardial infarction - a meta-analysis of randomized trials JAMA-Journal of the American Medical Association  2005 293:1759-1765  DOI:10.1001/jama.293.14.1759  PMID:15827315
  • Serebruany, V. L., Steinhubl, S. R., Berger, P. B., Malinin, A. I., Baggish, J. S., Bhatt, D. L., Topol, E. J. Analysis of risk of bleeding complications after different doses of aspirin in 192,036 patients enrolled in 31 randomized controlled trials American Journal of Cardiology  2005 95:1218-1222  DOI:10.1016/j.amjcard.2005.01.049  PMID:15877994
  • Jefferson, B. K., Foster, J. H., McCarthy, J. J., Ginsburg, G., Parker, A., Kottke-Marchant, K., Topol, E. J. Aspirin resistance and a single gene American Journal of Cardiology  2005 95:805-808  DOI:10.1016/j.amjcard.2004.11.045  PMID:15757620
  • Mehta, R. H., Califf, R. M., Garg, J., Pieper, K. S., Alexander, J. H., Moliterno, D. J., Van de Werf, F., Ohman, E. M., White, H. D., Topol, E. J., Granger, C. B. Association of height with outcomes in patients with acute myocardial infarction receiving reperfusion therapy American Journal of Cardiology  2005 95:1371-1375  DOI:10.1016/j.amjcard.2005.01.087  PMID:15904648
  • Chew, D. P., Lincoff, A. M., Gurm, H., Wolski, K., Cohen, D. J., Henry, T., Feit, F., Topol, E. J., Invest, Replace- Bivalirudin versus heparin and glycoprotein iib/iiia inhibition among patients with renal impairment undergoing percutaneous coronary intervention (a subanalysis of the replace-2 trial) American Journal of Cardiology  2005 95:581-585  DOI:10.1016/j.amjcard.2004.11.003  PMID:15721095
  • Ebrahimi, R., Lincoff, A. M., Bittl, J. A., Chew, D., Wolski, K., Wadhan, N., Toggart, E. J., Topol, E. J. Bivalirudin vs heparin in percutaneous coronary intervention: A pooled analysis Journal of Cardiovascular Pharmacology and Therapeutics  2005 10:209-216  DOI:10.1177/107424840501000401  PMID:16382257
  • Bhatt, D. L., Topol, E. J. Cardiac enzyme elevation after successful percutaneous coronary intervention is not an independent predictor of adverse outcomes. Response Circulation  2005 112:922-922
  • Wang, K., Tarakji, K., Zhou, Z. M., Zhang, M., Forudi, F., Zhou, X. R., Koki, A. T., Smith, M. E., Keller, B. T., Topol, E. J., Lincoff, A. M., Penn, M. S. Celecoxib, a selective cyclooxygenase-2 inhibitor, decreases monocyte chemoattractant protein-1 expression and neointimal hyperplasia in the rabbit atherosclerotic balloon injury model Journal of Cardiovascular Pharmacology  2005 45:61-67  DOI:10.1097/00005344-200501000-00011  PMID:15613981
  • Mahaffey, K. W., Roe, M. T., Kilaru, R., French, J. K., Alexander, J. H., Berdan, L. G., Van De Werf, F., Simoons, M. L., Weaver, W. D., White, H. D., Lincoff, A. M., Kleiman, N. S., et al. Characterization of myocardial infarction as an end point in two large trials of acute coronary syndromes American Journal of Cardiology  2005 95:1404-1408  DOI:10.1016/j.amjcard.2005.02.005  PMID:15950560
  • Rebeiz, A. G., Johanson, P., Green, C. L., Crater, S. W., Roe, M. T., Langer, A., Giugliano, R. P., Lincoff, A. M., Newby, L. K., Harrington, R. A., Topol, E. J., Califf, R. M., et al. Comparison of st-segment resolution with combined fibrinolytic and glycoprotein iib/iiia inhibitor therapy versus fibrinolytic alone (data from four clinical trials) American Journal of Cardiology  2005 95:611-614  DOI:10.1016/j.amjcard.2004.10.038  PMID:15721101
  • Chan, A. W., Yadav, J. S., Bhatt, D. L., Bajzer, C. T., Gum, P. A., Roffi, M., Cho, L., Agah, R., Topol, E. J. Comparison of the safety and efficacy of emboli prevention devices versus platelet glycoprotein IIb/IIIa inhibition during carotid stenting American Journal of Cardiology  2005 95:791-795  DOI:10.1016/j.amjcard.2004.11.041  PMID:15757616
  • Agah, R., Ellis, S., Chase, S., Henderson, M., Mlady, L., Murugesan, G., Tubbs, R., Marchant, K., Warshawsky, I., Rouse, C., Hughes, K., Welch, P., et al. Creation of a large-scale genetic data bank for cardiovascular association studies American Heart Journal  2005 150:500-506  DOI:10.1016/j.ahj.2005.03.063  PMID:16169331
  • Sinnaeve, P. R., Simes, J., Yusuf, S., Garg, J., Mehta, S., Eikelboom, J., Bittl, J. A., Serruys, P., Topol, E. J., Granger, C. B. Direct thrombin inhibitors in acute coronary syndromes: Effect in patients undergoing early percutaneous coronary intervention European Heart Journal  2005 26:2396-2403  DOI:10.1093/eurheartj/ehi590  PMID:16214829
  • Bhatt, D. L., Topol, E. J. Does creatinine kinase-mb elevation after percutaneous coronary intervention predict outcomes in 2005? Periprocedural cardiac enzyme elevation predicts adverse outcomes Circulation  2005 112:906-915  DOI:10.1161/circulationaha.104.483297  PMID:16087811
  • Nissen, S. E., Wolski, K., Topol, E. J. Effect of muraglitazar on death and major adverse cardiovascular events in patients with type 2 diabetes mellitus JAMA-Journal of the American Medical Association  2005 294:2581-2586  DOI:10.1001/jama.294.20.joc50147  PMID:16239637
  • Gurm, H. S., Rajagopal, V., Fathi, R., Vivekanathan, D., Yadav, J. S., Bhatt, D. L., Ellis, S. G., Lincoff, A. M., Topol, E. J. Effectiveness and safety of bivalirudin during percutaneous coronary intervention in a single medical center American Journal of Cardiology  2005 95:716-721  DOI:10.1016/j.amjcard.2004.11.021  PMID:15757596
  • Hakonarson, H., Thorvaldsson, S., Helgadottir, A., Gudbjartsson, D., Zink, F., Andresdottir, M., Manolescu, A., Arnar, D. O., Andersen, K., Sigurdsson, A., Thorgeirsson, G., Jonsson, A., et al. Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction - a randomized trial JAMA-Journal of the American Medical Association  2005 293:2245-2256  DOI:10.1001/jama.293.18.2245  PMID:15886380
  • Savonitto, S., Cohen, M. G., Politi, A., Hudson, M. P., Kong, D. F., Huang, Y., Pieper, K. S., Mauri, F., Wagner, G. S., Califf, R. M., Topol, E. J., Granger, C. B. Extent of st-segment depression and cardiac events in non-st-segment elevation acute coronary syndromes European Heart Journal  2005 26:2106-2113  DOI:10.1093/eurheartj/ehi395  PMID:15987706
  • Shiffman, D., Ellis, S. G., Rowland, C. M., Malloy, M. J., Luke, M. M., Iakoubova, O. A., Pullinger, C. R., Cassano, J., Aouizerat, B. E., Fenwick, R. G., Reitz, R. E., Catanese, J. J., et al. Identification of four gene variants associated with myocardial infarction American Journal of Human Genetics  2005 77:596-605  DOI:10.1086/491674  PMID:16175505  PMCID:PMC1275608
  • Meine, T. J., Al-Khatib, S. M., Alexander, J. H., Granger, C. B., White, H. D., Kilaru, R., Williams, K., Ohman, E. M., Topol, E., Califf, R. M. Incidence, predictors, and outcomes of high-degree atrioventricular block complicating acute myocardial infarction treated with thrombolytic therapy American Heart Journal  2005 149:670-674  DOI:10.1016/j.ahj.2004.07.035  PMID:15990751
  • Beinart, S. C., Kolm, P., Veledar, E., Zhang, Z. F., Mahoney, E. M., Bouin, O., Gabriel, S., Jackson, J., Chen, R., Caro, J., Steinhubl, S., Topol, E., et al. Long-term cost effectiveness of early and sustained dual oral antiplatelet therapy with clopidogrel given for up to one year after percutaneous coronary intervention - results from the clopidogrel for the reduction of events during observation (credo) trial Journal of the American College of Cardiology  2005 46:761-769  DOI:10.1016/j.jacc.2005.03.073  PMID:16139122
  • Pluskota, E., Stenina, O. I., Krukovets, I., Szpak, D., Topol, E. J., Plow, E. F. Mechanism and effect of thrombospondin-4 polymorphisms on neutrophil function Blood  2005 106:3970-3978  DOI:10.1182/blood-2005-03-1292  PMID:16099885  PMCID:PMC1895095
  • Jefferson, B. K., Topol, E. J., Gersh, B. J. Molecular mechanisms of myocardial infarction Current Problems in Cardiology  2005 30:333-374  DOI:10.1016/j.cpcardiol.2005.02.002  PMID:15973291
  • Mukherjee, D., Topol, E. J., Bertrand, M. E., Kristensen, S. D., Herrmann, H. C., Neumann, F. J., Yakubov, S. J., Bassand, J. P., McClure, R. R., Stone, G. W., Ardissino, D., Moliterno, D. J., et al. Mortality at 1 year for the direct comparison of tirofiban and abciximab during percutaneous coronary revascularization: Do tirofiban and reopro give similar efficacy outcomes at trial 1-year follow-up European Heart Journal  2005 26:2524-2528  DOI:10.1093/eurheartj/ehi459  PMID:16107485
  • Vasilyev, N., Williams, T., Brennan, M. L., Unzek, S., Zhou, X. R., Heinecke, J. W., Spitz, D. R., Topol, E. J., Hazen, S. L., Penn, M. S. Myeloperoxidase-generated oxidants modulate left ventricular remodeling but not infarct size after myocardial infarction Circulation  2005 112:2812-2820  DOI:10.1161/circulationaha.105.542340  PMID:16267254
  • Chen, M. S., Bhatt, D. L., Chew, D. P., Moliterno, D. J., Ellis, S. G., Topol, E. J. Outcomes in african americans and whites after percutaneous coronary intervention American Journal of Medicine  2005 118:1019-1025  DOI:10.1016/j.amjmed.2004.12.035  PMID:16164889
  • Labinaz, M., Mathias, J., Pieper, K., Granger, C. B., Lincoff, A. M., Moliterno, D. J., Van de Werf, F., Simes, J., White, H. D., Simoons, M. L., Califf, R. M., Topol, E. J., et al. Outcomes of patients with acute coronary syndromes and prior percutaneous coronary intervention: A pooled analysis of three randomized clinical trials European Heart Journal  2005 26:128-136  DOI:10.1093/eurheartj/ehi061  PMID:15618068
  • Wang, K., Zhou, X. R., Zhou, Z. M., Mal, N., Fan, L. M., Zhang, M., Lincoff, A. M., Plow, E. F., Topol, E. J., Penn, M. S. Platelet, not endothelial, p-selectin is required for neointimal formation after vascular injury Arteriosclerosis, Thrombosis, and Vascular Biology  2005 25:1584-1589  DOI:10.1161/01.ATV.0000172687.01179.d4  PMID:15947246
  • Stenina, O. I., Ustinov, V., Krukovets, I., Marinic, T., Topol, E. J., Plow, E. F. Polymorphisms a387p in thrombospondin-4 and n700s in thrombospondin-1 perturb calcium binding sites FASEB Journal  2005 19:1893-1895  DOI:10.1096/fj.05-3712fje  PMID:16148025
  • Topol, E. J. The genomic basis of myocardial infarction Journal of the American College of Cardiology  2005 46:1456-1465  DOI:10.1016/j.jacc.2005.06.064  PMID:16226168
  • Berger, P. B., Best, P. J. M., Topol, E. J., White, J., DiBattiste, P. M., Chan, A. W., Kristensen, S. D., Herrmann, H. C., Moliterno, D. J. The relation of renal function to ischemic and bleeding outcomes with 2 different glycoprotein iib/iiia inhibitors: The do tirofiban and reopro give similar efficacy outcome (target) trial American Heart Journal  2005 149:869-875  DOI:10.1016/j.ahj.2004.12.002  PMID:15894970
  • Brener, S. J., Lincoff, A. M., Bates, E. R., Jia, G., Armstrong, P. W., Guetta, V., Hochman, J. S., Savonitto, S., Wilcox, R. G., White, H. D., Topol, E. J., Investigators, Gusto V. The relationship between baseline risk and mortality in st-elevation acute myocardial infarction treated with pharmacological reperfusion: Insights from the global utilization of strategies to open occluded arteries (gusto) v trial American Heart Journal  2005 150:89-93  DOI:10.1016/j.ahj.2005.01.030  PMID:16084153
  • Narizhneva, N. V., Razorenova, O. V., Podrez, E. A., Chen, J. H., Chandrasekharan, U. M., DiCorleto, P. E., Plow, E. F., Topol, E. J., Byzova, T. V. Thrombospondin-1 up-regulates expression of cell adhesion molecules and promotes monocyte binding to endothelium FASEB Journal  2005 19:1158-1160  DOI:10.1096/fj.04-3310fje  PMID:15833768  PMCID:PMC1569946
  • Guo, Z., Zhang, T. W., Li, X., Wang, Q., Xu, J. Z., Yu, H., Zhu, J., Wang, H. Y., Wang, C. G., Topol, E. J., Rao, S. Q. Towards precise classification of cancers based on robust gene functional expression profiles BMC Bioinformatics  2005 6:58  DOI:10.1186/1471-2105-6-58  PMID:15774002  PMCID:PMC1274255
  • Gurm, H. S., Sarembock, I. J., Kereiakes, D. J., Young, J. J., Harrington, R. A., Kleiman, N., Feit, F., Wolski, K., Bittl, J. A., Wilcox, R., Topol, E. J., Lincoff, A. M., et al. Use of bivalirudin during percutaneous coronary intervention in patients with diabetes mellitus - an analysis from the randomized evaluation in percutaneous coronary intervention linking angiomax to reduced clinical events (replace)-2 trial Journal of the American College of Cardiology  2005 45:1932-1938  DOI:10.1016/j.jacc.2005.02.074  PMID:15963389
  • Serebruany, V. L., Steinhubl, S. R., Berger, P. B., Malinin, A. I., Bhatt, D. L., Topol, E. J. Variability in platelet responsiveness to clopidogrel among 544 individuals Journal of the American College of Cardiology  2005 45:246-251  DOI:10.1016/j.jacc.2004.09.067  PMID:15653023
  • Brener, S. J., Topol, E. J. Adjunctive therapy for percutaneous revascularization in acute myocardial infarction Current Pharmaceutical Design  2004 10:399-405  DOI:10.2174/1381612043453333  PMID:14965201
  • Li, X., Rao, S. Q., Zhang, T. W., Guo, Z., Zhang, Q. P., Moser, K. L., Topol, E. J. An ensemble method for gene discovery based on DNA microarray data Science in China Series C-Life Sciences  2004 47:396-405  DOI:10.1360/03yc0127  PMID:15623151
  • Quinn, M. J., Aronow, H. D., Calif, R. M., Bhatt, D. L., Sapp, S., Kleiman, N. S., Harrington, R. A., Kong, D. F., Kandzari, D. E., Topol, E. J. Aspirin dose and six-month outcome after an acute coronary syndrome Journal of the American College of Cardiology  2004 43:972-978  DOI:10.1016/j.jacc.2003.09.059  PMID:15028352
  • Freedman, M. L., Reich, D., Penney, K. L., McDonald, G. J., Mignault, A. A., Patterson, N., Gabriel, S. B., Topol, E. J., Smoller, J. W., Pato, C. N., Pato, M. T., Petryshen, T. Y. L., et al. Assessing the impact of population stratification on genetic association studies Nature Genetics  2004 36:388-393  DOI:10.1038/ng1333  PMID:15052270
  • McGuire, D. K., Newby, L. K., Bhapkar, M. V., Moliterno, D. J., Hochman, J. S., Klein, W. W., Weaver, W. D., Pfisterer, M., Corbalan, R., Dellborg, M., Granger, C. B., Van de Werf, F., et al. Association of diabetes mellitus and glycemic control strategies with clinical outcomes after acute coronary syndromes American Heart Journal  2004 147:246-252  DOI:10.1016/j.ahj.2003.07.024  PMID:14760321
  • Asher, C. R., Moliterno, D. J., Bhapkar, M. V., McGuire, D. K., Rao, S. V., Holmes, D. R., Newby, L. K., Bates, E. R., Topol, E. J., Investigators, Symphony, Investigators, 2nd SYMPHONY Association of race with complications and prognosis fohowing acute coronary syndromes American Journal of Cardiology  2004 94:792-794  DOI:10.1016/j.amjcard.2004.05.069  PMID:15374792
  • Ringleb, P. A., Bhatt, D. L., Hirsch, A. T., Topol, E. J., Hacke, W., Investigators, Caprie Benefit of clopidogrel over aspirin is amplified in patients with a history of ischemic events Stroke  2004 35:528-532  DOI:10.1161/01.str.0000110221.54366.49  PMID:14739421
  • Askari, A., Unzek, S., Goldman, C. K., Ellis, S. G., Thomas, J. D., DiCorleto, P. E., Topol, E. J., Penn, M. S. Cellular, but not direct, adenoviral delivery of vascular endothelial growth factor results in improved left ventricular function and neovascularization in dilated ischemic cardiomyopathy Journal of the American College of Cardiology  2004 43:1908-1914  DOI:10.1016/j.jacc.2003.12.045  PMID:15145120
  • Bhatt, D. L., Topol, E. J., Comm, Charisma Executive Clopidogrel added to aspirin versus aspirin alone in secondary prevention and high-risk primary prevention: Rationale and design of the clopidogrel for high atherothrombotic risk and ischemic stabilization, management, and avoidance (charisma) trial American Heart Journal  2004 148:263-268  DOI:10.1016/j.ahj.2004.03.028  PMID:15308995
  • Lincoff, A. M., Bittl, J. A., Kleiman, N. S., Sarembock, I. J., Jackman, J. D., Mehta, S., Tannenbaum, M. A., Niederman, A. L., Bachinsky, W. B., Tift-Mann, J., Parker, H. G., Kereiakes, D. J., et al. Comparison of bivalirudin versus heparin during percutaneous coronary intervention (the randomized evaluation of pci linking angiomax to reduced clinical events replace -1 trial) American Journal of Cardiology  2004 93:1092-1096  DOI:10.1016/j.amjcard.2004.01.033  PMID:15110198
  • Saw, J., Topol, E. J., Steinhubl, S. R., Brennan, D., Berger, P. B., Moliterno, D. J., Investigators, Credo Comparison of long-term usefulness-of clopidogrel therapy after the first percutaneous coronary intervention or coronary artery bypass grafting versus that after the second or repeat intervention American Journal of Cardiology  2004 94:623-625  DOI:10.1016/j.amjcard.2004.05.026  PMID:15342293
  • Casserly, I., Topol, E. Convergence of atherosclerosis and alzheimer's disease: Inflammation, cholesterol, and misfolded proteins Lancet  2004 363:1139-1146  DOI:10.1016/s0140-6736(04)15900-x  PMID:15064035
  • Roe, M. T., Mahaffey, K. W., Kilaru, R., Alexander, J. H., Akkerhuis, K. M., Simoons, M. L., Harrington, R. A., Tardiff, B. E., Granger, C. B., Ohman, E. M., Moliterno, D. J., Lincoff, A. M., et al. Creatine kinase-mb elevation after percutaneous coronary intervention predicts adverse outcomes in patients with acute coronary syndromes European Heart Journal  2004 25:313-321  DOI:10.1016/j.ehj.2003.12.009  PMID:14984920
  • Gurm, H. S., Lincoff, A. M., Kleiman, N. S., Kereiakes, D. J., Tcheng, J. E., Aronow, H. D., Askari, A. T., Brennan, D. M., Topol, E. J. Double jeopardy of renal insufficiency and anemia in patients undergoing percutaneous coronary interventions American Journal of Cardiology  2004 94:30-34  DOI:10.1016/j.amjcard.2004.03.025  PMID:15219504
  • Cohen, D. J., Lincoff, A. M., Lavelle, T. A., Chen, H. L., Bakhai, A., Berezin, R. H., Jackman, D., Sarembock, I. J., Topol, E. J., Investigators, Replace- Economic evaluation of bivalirudin with provisional glycoprotein iib/iiia inhibition versus heparin with routine glycoprotein iib/iiia inhibition for percutaneous coronary intervention - results from the replace-2 trial Journal of the American College of Cardiology  2004 44:1792-1800  DOI:10.1016/j.jacc.2004.05.085  PMID:15519009
  • Nissen, S. E., Tuzcu, E. M., Libby, P., Thompson, P. D., Ghali, M., Garza, D., Berman, L., Shi, H., Buebendorf, E., Topol, E. J., Investigators, Camelot Effect of antihypertensive agents on cardiovascular events in patients with coronary disease and normal blood pressure the camelot study: A randomized controlled trial JAMA-Journal of the American Medical Association  2004 292:2217-2226  DOI:10.1001/jama.292.18.2217  PMID:15536108
  • Quinn, M. J., Bhatt, D. L., Zidar, F., Vivekananthan, D., Chew, D. P., Ellis, S. G., Plow, E., Topol, E. J. Effect of clopidogrel pretreatment on inflammatory marker expression in patients undergoing percutaneous coronary intervention American Journal of Cardiology  2004 93:679-684  DOI:10.1016/j.amjcard.2003.11.048  PMID:15019868
  • Vivekananthan, D. P., Bhatt, D. L., Chew, D. P., Zidar, F. J., Chan, A. W., Moliterno, D. J., Ellis, S. G., Topol, E. J. Effect of clopidogrel pretreatment on periprocedural rise in c-reactive protein after percutaneous coronary intervention American Journal of Cardiology  2004 94:358-360  DOI:10.1016/j.amjcard.2004.04.035  PMID:15276105
  • Ellis, S. G., Armstrong, P., Betriu, A., Brodie, B., Herrmann, H., Montalescot, G., Neumann, F. J., Smith, J. J., Topol, E., Investigators, Finesse Facilitated percutaneous coronary intervention versus primary percutaneous coronary intervention: Design and rationale of the facilitated intervention with enhanced reperfusion speed to stop events (finesse) trial American Heart Journal  2004 147  DOI:10.1016/j.ahj.2003.07.025
  • Chiu, J. H., Bhatt, D. L., Ziada, K. M., Chew, D. P., Whitlow, P. L., Lincoff, A. M., Ellis, S. G., Topol, E. J. Impact of female sex on outcome after percutaneous coronary intervention American Heart Journal  2004 148:998-1002  DOI:10.1016/j.ahj.2004.05.045  PMID:15632884
  • Kaul, P., Newby, L. K., Fu, Y. L., Mark, D. B., Califf, R. M., Topol, E. J., Aylward, P., Granger, C. B., Van de Werf, F., Armstrong, P. W., Grp, Vigour International differences in evolution of early discharge after acute myocardial infarction Lancet  2004 363:511-517  DOI:10.1016/s0140-6736(04)15536-0  PMID:14975612
  • Saw, J., Lincoff, A. M., DeSmet, W., Betriu, A., Rutsch, W., Wilcox, R. G., Kleiman, N. S., Wolski, K., Topol, E. J., Investigators, Replace- Lack of clopidogrel pretreatment effect on the relative efficacy of bivalirudin with provisional glycoprotein iib/iiia blockade compared to heparin with routine glycoprotein iib/iiia blockade - a replace-2 substudy Journal of the American College of Cardiology  2004 44:1194-1199  DOI:10.1016/j.jacc.2004.06.049  PMID:15364319
  • McCarthy, J. J., Parker, A., Salem, R., Moliterno, D. J., Wang, Q., Plow, E. F., Rao, S., Shen, G., Rogers, W. J., Newby, L. K., Cannata, R., Glatt, K., et al. Large scale association analysis for identification of genes underlying premature coronary heart disease: Cumulative perspective from analysis of 111 candidate genes Journal of Medical Genetics  2004 41:334-341  DOI:10.1136/jmg.2003.016584  PMID:15121769  PMCID:PMC1579684
  • Lincoff, A. M., Kleiman, N. S., Kereiakes, D. J., Feit, F., Bittl, J. A., Jackman, J. D., Sarembock, I. J., Cohen, D. J., Spriggs, D., Ebrahimi, R., Keren, G., Carr, J., et al. Long-term efficacy of bivalirudin and provisional glycoprotein iib/iiia blockade vs heparin and planned glycoprotein iib/iiia blockade during percutaneous coronary revascularization - replace-2 randomized trial JAMA-Journal of the American Medical Association  2004 292:696-703  DOI:10.1001/jama.292.6.696  PMID:15304466
  • Kaul, P., Armstrong, P. W., Chang, W. C., Naylor, C. D., Granger, C. B., Lee, K. L., Peterson, E. D., Califf, R. M., Topol, E. J., Mark, D. B. Long-term mortality of patients with acute myocardial infarction in the united states and canada - comparison of patients enrolled in global utilization of streptokinase and t-pa for occluded coronary arteries (gusto)-i Circulation  2004 110:1754-1760  DOI:10.1161/01.cir.0000142671.06167.91  PMID:15381645
  • Bittl, J. A., Chew, D. P., Topol, E. J., Kong, D. F., Calif, R. M. Meta-analysis of randomized trials of percutaneous transluminal coronary angioplasty versus atherectomy, cutting balloon atherotomy, or laser angioplasty Journal of the American College of Cardiology  2004 43:936-942  DOI:10.1016/j.jacc.2003.10.039  PMID:15028347
  • Narizhneva, N. V., Byers-Ward, V. J., Quinn, M. J., Zidar, F. J., Plow, E. F., Topol, E. J., Byzova, T. V. Molecular and functional differences induced in thrombospondin-1 by the single nucleotide polymorphism associated with the risk of premature, familial myocardial infarction Journal of Biological Chemistry  2004 279:21651-21657  DOI:10.1074/jbc.M311090200  PMID:15007078  PMCID:PMC1459418
  • Gurm, H. S., Lincoff, A. M., Lee, D., Tang, W. H. W., Jia, G., Booth, J. E., Califf, R. M., Ohman, E. M., Van de Werf, F., Armstrong, P. W., Guetta, V., Wilcox, R., et al. Outcome of acute st-segment elevation myocardial infarction in diabetics treated with fibrinolytic or combination reduced fibrinolytic therapy and platelet glycoprotein iib/iiia inhibition - lessons from the gusto v trial Journal of the American College of Cardiology  2004 43:542-548  DOI:10.1016/j.jacc.2003.09.038  PMID:14975461
  • Roffi, M., Topol, E. J. Percutaneous coronary intervention in diabetic patients with non-st-segment elevation acute coronary syndromes European Heart Journal  2004 25:190-198  DOI:10.1016/j.ehj.2003.10.027  PMID:14972418
  • Wang, Q., Rao, S. Q., Shen, G. Q., Li, L., Moliterno, D. J., Newby, L. K., Rogers, W. J., Cannata, R., Zirzow, E., Elston, R. C., Topol, E. J. Premature myocardial infarction novel susceptibility locus on chromosome 1p34-36 identified by genomewide linkage analysis American Journal of Human Genetics  2004 74:262-271  DOI:10.1086/381560  PMID:14732905  PMCID:PMC1181924
  • Brener, S. J., Lytle, B. W., Casserly, I. P., Schneider, J. P., Topol, E. J., Lauer, M. S. Propensity analysis of long-term survival after surgical or percutaneous revascularization in patients with multivessel coronary artery disease and high-risk features Circulation  2004 109:2290-2295  DOI:10.1161/01.cir.0000126826.58526.14  PMID:15117846
  • Ellis, S. G., Bajzer, C. T., Bhatt, D. L., Brener, S. J., Whitlow, P. L., Lincoff, A. M., Moliterno, D. J., Raymond, R. E., Tuzcu, E. M., Franco, I., Dushman-Ellis, S., Lander, K. J. Real-world bare metal stenting: Identification of patients at low or very low risk of 9-month coronary revascularization Catheterization and Cardiovascular Interventions  2004 63:135-140  DOI:10.1002/ccd.20132  PMID:15390245
  • Rajagopal, V., Gurm, H. S., Bhatt, D. L., Lincoff, A. M., Tcheng, J. E., Kereiakes, D. J., Kleiman, N. S., Jia, G., Topol, E. J. Relation of an elevated white blood cell count after percutaneous coronary intervention to long-term mortality American Journal of Cardiology  2004 94:190-192  DOI:10.1016/j.amjcard.2004.03.060  PMID:15246898
  • Brener, S. J., Moliterno, D. J., Lincoff, A. M., Steinhubl, S. R., Wolski, K. E., Topol, E. J. Relationship between activated clotting time and ischemic or hemorrhagic complications - analysis of 4 recent randomized clinical trials of percutaneous coronary intervention Circulation  2004 110:994-998  DOI:10.1161/01.cir.0000139868.53594.24  PMID:15302778
  • Rao, S. V., Jollis, J. G., Harrington, R. A., Granger, C. B., Newby, L. K., Armstrong, P. W., Moliterno, D. J., Lindblad, L., Pieper, K., Topol, E. J., Stamler, J. S., Califf, R. M. Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes JAMA-Journal of the American Medical Association  2004 292:1555-1562  DOI:10.1001/jama.292.13.1555  PMID:15467057
  • Wessel, J., Topol, E. J., Ji, M., Meyer, J., McCarthy, J. J. Replication of the association between the thrombospondin-4 a387p polymorphism and myocardial infarction American Heart Journal  2004 147:905-909  DOI:10.1016/j.ahj.2003.12.013  PMID:15131549
  • Kandzari, D. E., Granger, C. B., Simoons, M. L., White, H. D., Simes, J., Mahaffey, K. W., Gore, J., Weaver, W. D., Longstreth, W. T., Stebbins, A., Lee, K. L., Califf, R. M., et al. Risk factors for intracranial hemorrhage and nonhemorrhagic stroke after fibrinolytic therapy (from the gusto-i trial) American Journal of Cardiology  2004 93:458-461  DOI:10.1016/j.amjcard.2003.10.043  PMID:14969623
  • Penn, M. S., Zhang, M., Deglurkar, I., Topol, E. J. Role of stem cell homing in myocardial regeneration International Journal of Cardiology  2004 95:S23-S25  DOI:10.1016/j.ijcard.2004.04.000  PMID:15336840
  • Cura, F. A., Roffi, M., Pasca, N., Wolski, K. E., Lincoff, A. M., Topol, E. J., Lauer, M. S., Global use of strategies to, open St-segment resolution 60 minutes after combination treatment of abciximab with reteplase or reteplase alone for acute myocardial infarction (30-day mortality results from the resolution of st-segment after reperfusion therapy substudy) American Journal of Cardiology  2004 94:859-863  DOI:10.1016/j.amjcard.2004.06.018  PMID:15464665
  • Maroo, A., Topol, E. J. The early history and development of thrombolysis in acute myocardial infarction Journal of Thrombosis and Haemostasis  2004 2:1867-1870  DOI:10.1111/j.1538-7836.2004.00881.x  PMID:15550011
  • Helgadottir, A., Manolescu, A., Thorleifsson, G., Gretarsdottir, S., Jonsdottir, H., Thorsteinsdottir, U., Samani, N. J., Gudmundsson, G., Grant, S. F. A., Thorgeirsson, G., Sveinbjornsdottir, S., Valdimarsson, E. M., et al. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke Nature Genetics  2004 36:233-239  DOI:10.1038/ng1311  PMID:14770184
  • Merlini, P. A., Rossi, M., Menozzi, A., Buratti, S., Brennan, D. M., Moliterno, D. J., Topol, E. J., Ardissino, D. Thrombocytopenia caused by abciximab or tirofiban and its association with clinical outcome in patients undergoing coronary stenting Circulation  2004 109:2203-2206  DOI:10.1161/01.cir.0000127867.41621.85  PMID:15117843
  • Bhagavatula, M. R. K., Fan, C., Shen, G. Q., Cassano, J., Plow, E. F., Topol, E. J., Wang, Q. Transcription factor mef2a mutations in patients with coronary artery disease Human Molecular Genetics  2004 13:3181-3188  DOI:10.1093/hmg/ddh329  PMID:15496429  PMCID:PMC1579761
  • Exaire, J. E., Dauerman, H. L., Topol, E. J., Blankenship, J. C., Wolski, K., Raymond, R. E., Cohen, E. A., Moliterno, D. J., TARGET Investigators Triple antiplatelet therapy does not increase femoral access bleeding with vascular closure devices American Heart Journal  2004 147:31-34  DOI:10.1016/j.ahj.2003.07.019  PMID:14691415
  • Topol, E. J. A guide to therapeutic decision-making in patients with non-st-segment elevation acute coronary syndromes Journal of the American College of Cardiology  2003 41:123S-129S  DOI:10.1016/s0735-1097(02)02689-x
  • Migrino, R. Q., Topol, E. J. A matter of life and death? The heart protection study and protection of clinical trial participants Controlled Clinical Trials  2003 24:501-505  DOI:10.1016/s0197-2456(03)00091-6  PMID:14500049
  • Gum, P. A., Kottke-Marchant, K., Welsh, P. A., White, J., Topol, E. J. A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease Journal of the American College of Cardiology  2003 41:961-965  DOI:10.1016/s0735-1097(02)03014-0  PMID:12651041
  • Brener, S. J., Ellis, S. G., Schneider, J., Apperson-Hansen, C., Topol, E. J. Abciximab-facilitated percutaneous coronary intervention and long-term survival - a prospective single-center registry European Heart Journal  2003 24:630-638  DOI:10.1016/s0195-668x(02)00812-6  PMID:12657221
  • Cho, L., Bhatt, D. L., Marso, S. P., Brennan, D., Holmes, D. R., Califf, R. M., Topol, E. J. An invasive strategy is associated with decreased mortality in patients with unstable angina and non-st-elevation myocardial infarction: Gusto iib trial American Journal of Medicine  2003 114:106-111  DOI:10.1016/s0002-9343(02)01446-8  PMID:12586229
  • Ross, M. J., Herrmann, H. C., Moliterno, D. J., Blankenship, J. C., Demopoulos, L., DiBattiste, P. M., Ellis, S. G., Ghazzal, Z., Martin, J. L., White, J., Topol, E. J. Angiographic variables predict increased risk for adverse ischernic events after coronary stenting with glycoprotein iib/iiia inhibition - results from the target trial Journal of the American College of Cardiology  2003 42:981-988  DOI:10.1016/s0735-1097(03)00913-6  PMID:13678916
  • Yen, M. H., Bhatt, D. L., Chew, D. P., Harrington, R. A., Newby, L. K., Ardissino, D., Van de Werf, F., White, J. A., Moliterno, D. J., Topol, E. J. Association between admission white blood cell count and one-year mortality in patients with acute coronary syndromes American Journal of Medicine  2003 115:318-321  DOI:10.1016/s0002-9343(03)00358-9  PMID:12967697
  • McCarthy, J. J., Lehner, T., Reeves, C., Moliterno, D. J., Newby, L. K., Rogers, W. J., Topol, E. J., GeneQuest, Invest Association of genetic variants in the hdl receptor, sr-b1, with abnormal lipids in women with coronary artery disease Journal of Medical Genetics  2003 40:453-458  DOI:10.1136/jmg.40.6.453  PMID:12807968  PMCID:PMC1735488
  • Lincoff, A. M., Bittl, J. A., Harrington, R. A., Feit, F., Kleiman, N. S., Jackman, J. D., Sarembock, I. J., Cohen, D. J., Spriggs, D., Ebrahimi, R., Keren, G., Carr, J., et al. Bivalirudin and provisional glycoprotein iib/iiia blockade compared with heparin and planned glycoprotein iib/iiia blockade during percutaneous coronary intervention - replace-2 randomized trial JAMA-Journal of the American Medical Association  2003 289:853-863  DOI:10.1001/jama.289.7.853  PMID:12588269
  • Wang, K., Zhou, X. R., Zhou, Z. M., Tarakji, K., Carneiro, M., Penn, M. S., Murray, D., Klein, A., Humphries, R. G., Turner, J., Thomas, J. D., Topol, E. J., et al. Blockade of the platelet p2y(12) receptor by ar-c69931mx sustains coronary artery recanalization and improves the myocardial tissue perfusion in a canine thrombosis model Arteriosclerosis, Thrombosis, and Vascular Biology  2003 23:357-362  DOI:10.1161/01.atv.0000052669.50791.0b  PMID:12588784
  • L'Allier, P. L., Aronow, H. D., Cura, F. A., Bhatt, D. L., Albirini, A., Schneider, J. P., Topol, E. J., Ellis, S. G. Clopidogrel is associated with better in-hospital and 30-day outcomes than ticlopidine after coronary stenting Canadian Journal of Cardiology  2003 19:1041-1046  PMID:12915931
  • Topol, E. J. Current status and future prospects for acute myocardial infarction therapy Circulation  2003 108:6-13  DOI:10.1161/01.CIR.0000086950.37612.7b  PMID:12847052
  • Mukherjee, D., Topol, E. J. Cyclooxygenase-2: Where are we in 2003? Cardiovascular risk and cox-2 inhibitors Arthritis Research & Therapy  2003 5:8-11  DOI:10.1186/ar609  PMID:12716442  PMCID:PMC154429
  • Casserly, I. P., Topol, E. J., Jia, G., Lange, R. A., Hamm, C., Meier, B., DiBattiste, P. M., Lakkis, N., Chew, D. P., Stone, G. W., Cohen, D. J., Moliterno, D. J. Effect of abciximab versus tirofiban on activated clotting time during percutaneous intervention and its relation to clinical outcomes - observations from the target trial American Journal of Cardiology  2003 92:125-129  DOI:10.1016/s0002-9149(03)00525-3  PMID:12860211
  • Bhatt, D. L., Chew, D. P., Lincoff, A. M., Simoons, M. L., Harrington, R. A., Ommen, S. R., Jia, G., Topol, E. J., Investigators, Pursuit Effect of revascularization on mortality associated with an elevated white blood cell count in acute coronary syndromes American Journal of Cardiology  2003 92:136-140  DOI:10.1016/s0002-9149(03)00527-7  PMID:12860213
  • Askari, A. T., Unzek, S., Popovic, Z. B., Goldman, C. K., Forudi, F., Kiedrowski, M., Rovner, A., Ellis, S. G., Thomas, J. D., DiCorleto, P. E., Topol, E. J., Penn, M. S. Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy Lancet  2003 362:697-703  DOI:10.1016/s0140-6736(03)14232-8  PMID:12957092
  • Cura, F. A., Kapadia, S. R., L'Allier, P. L., Ziada, K. M., Mukherjee, D., Wolski, K. E., Yadav, J. S., Brener, S. J., Whitlow, P. L., Topol, E. J., Ellis, S. G. Effect of uncoated stenting versus balloon angioplasty alone of long coronary (> 20 mm) versus shorter narrowings on one-year event-free survival American Journal of Cardiology  2003 91:587-590  DOI:10.1016/s0002-9149(02)03313-1  PMID:12615267
  • McCarthy, J. J., Meyer, J., Moliterno, D. J., Newby, L. K., Rogers, W. J., Topol, E. J. Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients Human Genetics  2003 114:87-98  DOI:10.1007/s00439-003-1026-1  PMID:14557872
  • Tolleson, T. R., Newby, L. K., Harrington, R. A., Bhapkar, M. V., Verheught, F. W. A., Berger, P. B., Moliterno, D. J., White, H. D., Ohman, E. M., Van de Werf, F., Topol, E. J., Califf, R. M., et al. Frequency of stent thrombosis after acute coronary syndromes (from the symphony and 2nd symphony trials) American Journal of Cardiology  2003 92:330-333  DOI:10.1016/s0002-9149(03)00641-6  PMID:12888148
  • Hasdai, D., Topol, E. J., Kilaru, R., Battler, A., Harrington, R. A., Vahanian, A., Ohman, E. M., Granger, C. B., Van de Werf, F., Simoons, M. L., O'Connor, C. M., Holmes, D. R. Frequency, patient characteristics, and, outcomes of mild-to-moderate heart failure complicating st-segment elevation acute myocardial infarction: Lessons from 4 international fibrinolytic therapy trials American Heart Journal  2003 145:73-79  DOI:10.1067/mhj.2003.53  PMID:12514657
  • Rao, S. Q., Li, L., Li, X., Moser, K. L., Guo, Z., Shen, G. Q., Cannata, R., Zirzow, E., Topol, E. J., Wang, Q. Genetic linkage analysis of longitudinal hypertension phenotypes using three summary measures BMC Genetics  2003 4:S24  DOI:10.1186/1471-2156-4-s1-s24  PMID:14975092
  • Archacki, S. R., Angheloiu, G., Tian, X. L., Tan, F. L., DiPaola, N., Shen, G. Q., Moravec, C., Ellis, S., Topol, E. J., Wang, Q. Identification of new genes differentially expressed in coronary artery disease by expression profiling Physiological Genomics  2003 15:65-74  DOI:10.1152/physiolgenomics.00181.2002  PMID:12902549
  • Khadour, F. H., Fu, Y. L., Chang, W. C., Ma, X., Mark, D., Granger, C. B., Topol, E. J., Califf, R. M., Armstrong, P. W., investigators, Gusto IIb Impact of on-site cardiac interventional facilities on management and outcome of patients with acute coronary syndromes Canadian Journal of Cardiology  2003 19:257-263  PMID:12677281
  • Gurm, H. S., Bhatt, D. L., Lincoff, A. M., Tcheng, J. E., Kereiakes, D. J., Kleiman, N. S., Jia, G., Topol, E. J. Impact of preprocedural white blood cell count on long term mortality after percutaneous coronary intervention: Insights from the epic, epilog, and epistent trials Heart  2003 89:1200-1204  DOI:10.1136/heart.89.10.1200  PMID:12975419
  • Aronow, H. D., Novaro, G. M., Lauer, M. S., Brennan, D. M., Lincoff, A. M., Topol, E. J., Kereiakes, D. J., Nissen, S. E. In-hospital initiation of lipid-lowering therapy after coronary intervention as a predictor of long-term utilization - a propensity analysis Archives of Internal Medicine  2003 163:2576-2582  DOI:10.1001/archinte.163.21.2576  PMID:14638557
  • Stenina, O. I., Krukovets, I., Wang, K., Zhou, Z. M., Forudi, F., Penn, M. S., Topol, E. J., Plow, E. F. Increased expression of thrombospondin-1 in vessel wall of diabetic zucker rat Circulation  2003 107:3209-3215  DOI:10.1161/01.cir.0000074223.56882.97  PMID:12810612
  • Quinn, M. J., Byzova, T. V., Qin, J., Topol, E. J., Plow, E. F. Integrin alpha(iib)beta(3) and its antagonism Arteriosclerosis, Thrombosis, and Vascular Biology  2003 23:945-952  DOI:10.1161/01.atv.0000066686.46338.f1  PMID:12637342
  • Kramer, J. M., Newby, L. K., Chang, W. C., Simes, R. J., Van de Werf, F., Granger, C. B., Lee, K. L., White, H. D., Piegas, L. S., Topol, E. J., Califf, R. M., Armstrong, P. W., et al. International variation in the use of evidence-based medicines for acute coronary syndromes European Heart Journal  2003 24:2133-2141  DOI:10.1016/j.ehj.2003.09.018  PMID:14643274
  • Saw, J., Steinhubl, S. R., Berger, P. B., Kereiakes, D. J., Serebruany, V. L., Brennan, D., Topol, E. J., Clopidogrel Reduction Events, Durin Lack of adverse clopidogrel-atorvastatin clinical interaction from secondary analysis of a randomized, placebo-controlled clopidogrel trial Circulation  2003 108:921-924  DOI:10.1161/01.cir.0000088780.57432.43  PMID:12925453
  • Wang, K., Kessler, P. D., Zhou, Z. M., Penn, M. S., Forudi, F., Zhou, X. R., Tarakji, K., Kibbe, M., Kovesdi, I., Brough, D. E., Topol, E. J., Lincoff, A. M. Local adenoviral-mediated inducible nitric oxide synthase gene transfer inhibits neointimal formation in the porcine coronary stented model Molecular Therapy  2003 7:597-603  DOI:10.1016/s1525-0016(03)00061-3  PMID:12718902
  • Ottervanger, J. P., Armstrong, P., Barnathan, E. S., Boersma, E., Cooper, J. S., Ohman, E. M., James, S., Topol, E., Wallentin, L., Simoons, M. L., Invest, Gusto Iv-Acs Long-term results after the glycoprotein iib/iiia inhibitor abciximab in unstable angina - one-year survival in the gusto iv-acs (global use of strategies to open occluded coronary arteries iv - acute coronary syndrome) trial Circulation  2003 107:437-442  DOI:10.1161/01.cir0000046487.06811.5e  PMID:12551868
  • Kong, D. F., Hasselblad, V., Harrington, R. A., White, H. D., Tcheng, J. E., Kandzari, D. E., Topol, E. J., Califf, R. M. Meta-analysis of survival with platelet glycoprotein IIb/IIIa antagonists for percutaneous coronary interventions American Journal of Cardiology  2003 92:651-655  DOI:10.1016/s002-9149(03)00816-6  PMID:12972100
  • Guo, Z., Li, X., Rao, S. Q., Moser, K. L., Zhang, T. W., Gong, B. S., Shen, G. Q., Li, L., Cannata, R., Zirzow, E., Topol, E. J., Wang, Q. Multivariate sib-pair linkage analysis of longitudinal phenotypes by three step-wise analysis approaches BMC Genetics  2003 4:S68  DOI:10.1186/1471-2156-4-s1-s68  PMID:14975136
  • Wang, L. J., Fan, C., Topol, S. E., Topol, E. J., Wang, Q. Mutation of mef2a in an inherited disorder with features of coronary artery disease Science  2003 302:1578-1581  DOI:10.1126/science.1088477  PMID:14645853  PMCID:PMC1618876
  • Askari, A. T., Brennan, M. L., Zhou, X. R., Drinko, J., Morehead, A., Thomas, J. D., Topol, E. J., Hazen, S. L., Penn, M. S. Myeloperoxidase and plasminogen activator inhibitor 1 play a central role in ventricular remodeling after myocardial infarction Journal of Experimental Medicine  2003 197:615-624  DOI:10.1084/jem.20021426  PMID:12615902  PMCID:PMC2193831
  • James, S. K., Lindahl, B., Siegbahn, A., Stridsberg, M., Venge, P., Armstrong, P., Barnathan, E. S., Califf, R., Topol, E. J., Simoons, M. L., Wallentin, L. N-terminal pro-brain natriuretic peptide and other risk markers for the separate prediction of mortality and subsequent myocardial infarction in patients with unstable coronary artery disease - a global utilization of strategies to open occluded arteries (gusto)-iv substudy Circulation  2003 108:275-281  DOI:10.1161/01.cir.0000079170.10579.dc  PMID:12847065
  • Chiu, J. H., Topol, E. J., Whitlow, P. L., Hsu, A. P., Tuzcu, E. M., Franco, I., Moliterno, D. J. Peripheral vascular disease and one-year mortality following percutaneous coronary revascularization American Journal of Cardiology  2003 92:582-583  DOI:10.1016/s0002-9149(03)00726-4  PMID:12943879
  • Newby, L. K., Bhapkar, M. V., White, H. D., Topol, E. J., Dougherty, F. C., Harrington, R. A., Smith, M. C., Asarch, L. F., Califf, R. M., Investigators, Symphony, Investigators, 2nd Symphony Predictors of 90-day outcome in patients stabilized after acute coronary syndromes European Heart Journal  2003 24:172-181  DOI:10.1016/s0195-668x(03)00325-1  PMID:12573274
  • Gurm, H. S., Bhatt, D. L., Gupta, R., Ellis, S. G., Topol, E. J., Lauer, M. S. Preprocedural white blood cell count and death after percutaneous coronary intervention American Heart Journal  2003 146:692-698  DOI:10.1016/s0002-8703(03)00230-8  PMID:14564325
  • Khot, U. N., Khot, M. B., Bajzer, C. T., Sapp, S. K., Ohman, E. M., Brener, S. J., Ellis, S. G., Lincoff, A. M., Topol, E. J. Prevalence of conventional risk factors in. Patients with coronary heart disease JAMA-Journal of the American Medical Association  2003 290:898-904  DOI:10.1001/jama.290.7.898  PMID:12928466
  • Grines, C., Patel, A., Zijlstra, F., Weaver, W. D., Granger, C., Simes, R. J., Ellis, S., Betriu, A., Garcia, E., Grinfeld, L., Gibbons, R., Ribeiro, E., et al. Primary coronary angioplasty compared with intravenous thrombolytic therapy for acute myocardial infarction: Six-month follow up and analysis of individual patient data from randomized trials American Heart Journal  2003 145:47-57  DOI:10.1067/mhj.2003.40  PMID:12514654
  • Khot, U. N., Jia, G., Moliterno, D. J., Lincoff, A. M., Khot, M. B., Harrington, R. A., Topol, E. J. Prognostic importance of physical examination for heart failure in non-st-elevation acute coronary syndromes - the enduring value of killip classification JAMA-Journal of the American Medical Association  2003 290:2174-2181  DOI:10.1001/jama.290.16.2174  PMID:14570953
  • Brennan, M., Penn, M. S., Van Lente, F., Nambi, V., Shishehbor, M. H., Aviles, R. J., Goormastic, M., Pepoy, M. L., McErlean, E. S., Topol, E. J., Nissen, S. E., Hazen, S. L. Prognostic value of myeloperoxidase in patients with chest pain New England Journal of Medicine  2003 349:1595-1604  DOI:10.1056/NEJMoa035003  PMID:14573731
  • You, S. A., Archacki, S. R., Angheloiu, G., Moravec, C. S., Rao, S. Q., Kinter, M., Topol, E. J., Wang, Q. Proteomic approach to coronary atherosclerosis shows ferritin light chain as a significant marker: Evidence consistent with iron hypothesis in atherosclerosis Physiological Genomics  2003 13:25-30  DOI:10.1152/physiolgenomics.00124.2002  PMID:12644631
  • Topol, E. J., Easton, D., Harrington, R. A., Amarenco, P., Califf, R. M., Graffagnino, C., Davis, S., Diener, H. C., Ferguson, J., Fitzgerald, D., Granett, J., Shuaib, A., et al. Randomized, double-blind, placebo-controlled, international trial of the oral iib/iiia antagonist lotrafiban in coronary and cerebrovascular disease Circulation  2003 108:399-406  DOI:10.1161/01.cir.0000084501.48570.f6  PMID:12874182
  • Zhou, Z. M., Wang, K., Penn, M. S., Marso, S. P., Lauer, M. A., Forudi, F., Zhou, X. R., Qu, W., Lu, Y., Stern, D. M., Schmidt, A. M., Lincoff, A. M., et al. Receptor for age (rage) mediates neointimal formation in response to arterial injury Circulation  2003 107:2238-2243  DOI:10.1161/01.cir.0000063577.32819.23  PMID:12719284
  • Topol, E. J., Kereiakes, D. J. Regionalization of care for acute ischemic heart disease - a call for specialized centers Circulation  2003 107:1463-1466  DOI:10.1161/01.cir.0000063680.45780.a0  PMID:12654599
  • Chan, A. W., Bhatt, D. L., Chew, D. P., Reginelli, J., Schneider, J. P., Topol, E. J., Ellis, S. G. Relation of inflammation and benefit of statins after percutaneous coronary interventions Circulation  2003 107:1750-1756  DOI:10.1161/01.cir.0000060541.18923.e9  PMID:12665489
  • Cho, L., Bhatt, D. L., Brennan, D., Wilcox, R. G., Topol, E. J. Relation of insurance status to performance of coronary angiography in patients with unstable angina pectoris or acute myocardial infarction American Journal of Cardiology  2003 91:721-723  DOI:10.1016/s0002-9149(02)03413-6  PMID:12633807
  • Brener, S. J., Bhatt, D. L., Moliterno, D. J., Schneider, J. P., Ellis, S. G., Topol, E. J. Revisiting optimal anticoagulation with unfractionated heparin during coronary stent implantation American Journal of Cardiology  2003 92:1468-1471  DOI:10.1016/j.amjcard.2003.08.063  PMID:14675590
  • Mukherjee, D., Hsu, A., Moliterno, D. J., Lincoff, A. M., Goormastic, M., Topol, E. J. Risk factors for premature coronary artery disease and determinants of adverse outcomes after revascularization in patients <= 40 years old American Journal of Cardiology  2003 92:1465-1467  DOI:10.1016/j.amjcard.2003.08.062  PMID:14675589
  • Savonitto, S., Armstrong, P. W., Lincoff, A. M., Jia, G., Sila, C. A., Booth, J., Terrosu, P., Cavallini, C., White, H. D., Ardissino, D., Califf, R. M., Topol, E. J., et al. Risk of intracranial haemorrhage with combined fibrinolytic and glycoprotein iib/iiia inhibitor therapy in acute myocardial infarction - dichotomous response as a function of age in the gusto v trial European Heart Journal  2003 24:1807-1814  DOI:10.1016/j.ehj.2003.07.004  PMID:14563339
  • Cho, L., Chew, D. P., Moliterno, D. J., Roffi, M., Ellis, S. G., Franco, I., Bajzer, C., Bhatt, D. L., Dorosti, K., Simpfendorder, C., Tuzcu, M., Yadav, J. S., et al. Safe and efficacious use of bivalirudin for percutaneous coronary intervention with adjunctive platelet glycoprotein IIb/IIIa receptor inhibition American Journal of Cardiology  2003 91:742-743  DOI:10.1016/s0002-9149(02)03420-3  PMID:12633814
  • Bhatt, D. L., Topol, E. J. Scientific and therapeutic advances in antiplatelet therapy Nature Reviews Drug Discovery  2003 2:15-28  DOI:10.1038/nrd985  PMID:12509756
  • Al-Khatib, S. M., Stebbins, A. L., Califf, R. M., Lee, K. L., Granger, C. B., White, H. D., Armstrong, P. W., Topol, E. J., Ohman, E. M. Sustained ventricular arrhythmias and mortality among patients with acute myocardial infarction: Results from the gusto-iii trial American Heart Journal  2003 145:515-521  DOI:10.1067/mhj.2003.170  PMID:12660676
  • Stenina, O. I., Desai, S. Y., Krukovets, I., Kight, K., Janigro, D., Topol, E. J., Plow, E. F. Thrombospondin-4 and its variants - expression and differential effects on endothelial cells Circulation  2003 108:1514-1519  DOI:10.1161/01.cir.0000089085.76320.4e  PMID:12952849
  • Roffi, M., Cattaneo, F., Topol, E. J. Thyrotoxicosis and the cardiovascular system: Subtle but serious effects Cleveland Clinic Journal of Medicine  2003 70:57-63  PMID:12549727
  • Newby, L. K., Hasselblad, V., Armstrong, P. W., Van de Werf, F. V., Mark, D. B., White, H. D., Topol, E. J., Califf, R. M. Time-based risk assessment after myocardial infarction. Implications for timing of discharge and applications to medical decision-making European Heart Journal  2003 24:182-189  DOI:10.1016/s0195-668x(03)00301-9  PMID:12573275
  • Chan, A. W., Moliterno, D. J., Berger, P. B., Stone, G. W., DiBattiste, P. M., Yakubov, S. L., Sapp, S. K., Wolski, K., Bhatt, D. L., Topol, E. J. Triple antiplatelet therapy during percutaneous coronary intervention is associated with improved outcomes including one-year survival - results from the do tirofiban and reopro give similar efficacy outcome trial (target) Journal of the American College of Cardiology  2003 42:1188-1195  DOI:10.1016/s0735-1097(03)00944-6  PMID:14522478
  • James, S. K., Armstrong, P., Barnathan, E., Califf, R., Lindahl, B., Siegbahn, A., Simoons, M. L., Topol, E. J., Venge, P., Wallentin, L., Investigators, Gusto-Iv-Acs Troponin and c-reactive protein have different relations to subsequent mortality and myocardial infarction after acute coronary syndrome - a gusto-iv substudy Journal of the American College of Cardiology  2003 41:916-924  DOI:10.1016/s0735-1097(02)02969-8  PMID:12651034
  • Kaul, P., Newby, L. K., Fu, Y. L., Hasselblad, V., Mahaffey, K. W., Christenson, R. H., Harrington, R. A., Ohman, E. M., Topol, E. J., Califf, R. M., Van de Werf, F., Armstrong, P. W., et al. Troponin t and quantitative st-segment depression offer complementary prognostic information in the risk stratification of acute coronary syndrome patients Journal of the American College of Cardiology  2003 41:371-380  DOI:10.1016/s0735-1097(02)02824-3  PMID:12575962
  • Vivekananthan, D. P., Penn, M. S., Sapp, S. K., Hsu, A., Topol, E. J. Use of antioxidant vitamins for the prevention of cardiovascular disease: Meta-analysis of randomised trials Lancet  2003 361:2017-2023  DOI:10.1016/s0140-6736(03)13637-9  PMID:12814711
  • Shishehbor, M. H., Bhatt, D. L., Topol, E. J. Using c-reactive protein to assess cardiovascular disease risk Cleveland Clinic Journal of Medicine  2003 70:634-640  PMID:12882386
  • Kereiakes, D. J., Lincoff, A. M., Anderson, K. M., Achenbach, R., Patel, K., Barnathan, E., Califf, R. M., Topol, E. J., Investigator, Epic Epilog Epistent Abciximab survival advantage following percutaneous coronary intervention is predicted by clinical risk profile American Journal of Cardiology  2002 90:628-30  DOI:10.1016/s0002-9149(02)02568-7  PMID:12231090
  • Zhou, Z. M., Penn, M. S., Forudi, F., Zhou, X. R., Tarakji, K., Topol, E. J., Lincoff, A. M., Wang, K. Administration of recombinant p-selectin glycoprotein ligand fc fusion protein suppresses inflammation and neointimal formation in zucker diabetic rat model Arteriosclerosis, Thrombosis, and Vascular Biology  2002 22:1598-1603  DOI:10.1161/01.atv.0000032676.20514.8f  PMID:12377736
  • Bhatt, D. L., Marso, S. P., Hirsch, A. T., Ringleb, P. A., Hacke, W., Topol, E. J. Amplified benefit of clopidogrel versus aspirin in patients with diabetes mellitus American Journal of Cardiology  2002 90:625-8  DOI:10.1016/s0002-9149(02)02567-5  PMID:12231089
  • Newby, L. K., Harrington, R. A., Bhapkar, M. V., Van de Werf, F., Hochman, J. S., Granger, C. B., Simes, R. J., Davis, C. G., Topol, E. J., Califf, R. M., Moliterno, D. J., Investigators, PARAGON A An automated strategy for bedside aptt determination and unfractionated heparin infusion adjustment in acute coronary syndromes: Insights from paragon a Journal of Thrombosis and Thrombolysis  2002 14:33-42  DOI:10.1023/a:1022062204490  PMID:12652148
  • Brener, S. J., Lytle, B. W., Schneider, J. P., Ellis, S. G., Topol, E. J. Association between ck-mb elevation after percutaneous or surgical revascularization and three-year mortality Journal of the American College of Cardiology  2002 40:1961-1967  DOI:10.1016/s0735-1097(02)02538-x  PMID:12475456
  • Penn, M. S., Francis, G. S., Ellis, S. G., Young, J. B., McCarthy, P. M., Topol, E. J. Autologous cell transplantation for the treatment of damaged myocardium Progress in Cardiovascular Diseases  2002 45:21-32  DOI:10.1053/pcad.2002.123466  PMID:12138412
  • Lincoff, A. M., Kleiman, N. S., Kottke-Marchant, K., Maierson, E. S., Maresh, K., Wolski, K. E., Topol, E. J. Bivalirudin with planned or provisional abciximab versus low-dose heparin and abciximab during percutaneous coronary revascularization: Results of the comparison of abciximab complications with hirulog for ischemic events trial (cachet) American Heart Journal  2002 143:847-853  DOI:10.1067/mhj.2002.122173  PMID:12040347
  • Breeman, A., Mercado, N., Lenzen, M., van den Brand, M. M. J., Harrington, R. A., Califf, R. M., Topol, E. J., Simoons, M. L., Boersma, E., Investigators, Pursuit Characteristics, treatment and outcome of patients with non-st-elevation acute coronary syndromes and multivessel coronary artery disease: Observations from pursuit (platelet glycoprotein iib/iiia in unstable angina: Receptor suppression using integrelin therapy) Cardiology  2002 98:195-201  DOI:10.1159/000067321  PMID:12566649
  • Ellis, S. G., Schneider, J. P., Topol, E. J. Comparison of long-term survival following non-Q-wave creatine kinase elevation after percutaneous coronary intervention in patients discharged on a beta blocker versus those not so treated American Journal of Cardiology  2002 89:751-753  DOI:10.1016/s0002-9149(01)02347-5  PMID:11897218
  • O'Shea, J. C., Wilcox, R. G., Skene, A. M., Stebbins, A. L., Granger, C. B., Armstrong, P. W., Bode, C., Ardissino, D., Emanuelsson, H., Aylward, P. H. E., White, H. D., Sadowski, Z., et al. Comparison of outcomes of patients with myocardial infarction when living alone versus those not living alone American Journal of Cardiology  2002 90:1374-1377  DOI:10.1016/s0002-9149(02)02876-x  PMID:12480048
  • Ellis, S. G., Chew, D., Chan, A., Whitlow, P. L., Schneider, J. P., Topol, E. J. Death following creatine kinase-mb elevation after coronary intervention - identification of an early risk period: Importance of creatine kinase-mb level, completeness of revascularization, ventricular function, and probable benefit of statin therapy Circulation  2002 106:1205-1210  DOI:10.1161/01.cir.0000028146.71416.2e  PMID:12208794
  • Yusuf, S., Granger, C., Eikelboom, J., Mehta, S., Pogue, J., Tait, P., Behar, S., Benderly, M., Hod, H., Kaplinsky, E., Barrett, N., Bilke, R., et al. Direct thrombin inhibitors in acute coronary syndromes: Principal results of a meta-analysis based on individual patients' data Lancet  2002 359:294-302  PMID:11830196
  • Steinhubl, S. R., Berger, P. B., Mann, J. T., Fry, E. T. A., DeLago, A., Wilmer, C., Topol, E. J., Investigators, Credo Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention - a randomized controlled trial JAMA-Journal of the American Medical Association  2002 288:2411-2420  DOI:10.1001/jama.288.19.2411  PMID:12435254
  • Chan, A. W., Bhatt, D. L., Chew, D. P., Quinn, M. J., Moliterno, D. J., Topol, E. J., Ellis, S. G. Early and sustained survival benefit associated with statin therapy at the time of percutaneous coronary intervention Circulation  2002 105:691-696  DOI:10.1161/hc0602.103586  PMID:11839623
  • Ronner, E., Boersma, E., Laarman, G. J., Somsen, G. A., Harrington, R. A., Deckers, J. W., Topol, E. J., Califf, R. M., Simoons, M. L. Early angioplasty in acute coronary syndromes without persistent st-segment elevation improves outcome but increases the need for six-month repeat revascularization - an analysis of the pursuit trial Journal of the American College of Cardiology  2002 39:1924-1929  DOI:10.1016/s0735-1097(02)01897-1  PMID:12084589
  • Topol, E. J. Economics and quality of care for patients with acute coronary syndromes: The impending crisis Clinical Cardiology  2002 25:I9-I15  PMID:12428814
  • Islam, M. A., Blankenship, J. C., Balog, C., Iliadis, E. A., Lincoff, M., Tcheng, J. E., Califf, R. M., Topol, E. J., Investigators, Epistent Effect of abciximab on angiographic complications during percutaneous coronary stenting in the evaluation of platelet iib/iiia inhibition in stenting trial (epistent) American Journal of Cardiology  2002 90:916-921  DOI:10.1016/s0002-9149(02)02653-x  PMID:12398954
  • Zhou, Z. M., Lauer, M. A., Wang, K., Forudi, F., Zhou, X. R., Song, X. Y., Solowski, N., Kapadia, S. R., Nakada, M. T., Topol, E. J., Lincoff, A. M. Effect of anti-tumor necrosis factor-alpha polyclonal antibody on restenosis after balloon angioplasty in a rabbit atherosclerotic model Atherosclerosis  2002 161:153-159  DOI:10.1016/s0021-9150(01)00640-2  PMID:11882327
  • Kottke-Marchant, K., Bahit, M. C., Granger, C. B., Zoldhelyi, P., Ardissino, D., Brooks, L., Griffin, J. H., Potthoff, R. F., Van de Werf, F., Califf, R. M., Topol, E. J. Effect of hirudin vs heparin on haemostatic activity in patients with acute coronary syndromes - the GUSTO-IIb haemostasis substudy European Heart Journal  2002 23:1202-1212  DOI:10.1053/euhj.2001.3074  PMID:12127922
  • Brener, S. J., Zeymer, U., Adgey, A. A. J., Vrobel, T. R., Ellis, S. G., Neuhaus, K. L., Juran, N., Ivanc, T. B., Ohman, E. M., Strony, J., Kitt, M., Topol, E. J., et al. Eptifibatide and low-dose tissue plasminogen activator in acute myocardial infarction - the integrilin and low-dose thrombolysis in acute myocardial infarction (intro ami) trial Journal of the American College of Cardiology  2002 39:377-386  DOI:10.1016/s0735-1097(01)01758-2  PMID:11823073
  • Ellis, S. G., Lincoff, A. M., Whitlow, P. L., Raymond, R. E., Franco, I., Schneider, J. P., Topol, E. J. Evidence that angiotensin-converting enzyme inhibitor use diminishes the need for coronary revascularization after stenting American Journal of Cardiology  2002 89:937-940  DOI:10.1016/s0002-9149(02)02242-7  PMID:11950431
  • Brener, S. J., Ellis, S. G., Schneider, J., Topol, E. J. Frequency and long-term impact of myonecrosis after coronary stenting European Heart Journal  2002 23:869-876  DOI:10.1053/euhj.2001.2976  PMID:12042008
  • Mazur, W., Kaluza, G. L., Sapp, S., Balog, C., Topol, E. J., Mark, D. B., Ellis, S. G., Kereiakes, D. J., Lincoff, A. M., Kleiman, N. S. Glycoprotein IIb-IIIa inhibition with abciximab and postprocedural risk assessment: lessons from the evaluation of platelet IIb/IIIa inhibitor for stenting trial and implication for ad hoc use of glycoprotein IIb-IIIa antagonists American Heart Journal  2002 143:594-601  DOI:10.1067/mhj.2002.121519  PMID:11923795
  • Casserly, I. P., Topol, E. J. Glycoprotein iib/iiia antagonists - from bench to practice Cellular and Molecular Life Sciences  2002 59:478-500  DOI:10.1007/s00018-002-8440-8  PMID:11964126
  • Gurm, H. S., Brennan, D. M., Booth, J., Tcheng, J. E., Lincoff, A. M., Topol, E. J. Impact of body mass index on outcome after percutaneous coronary intervention (the obesity paradox) American Journal of Cardiology  2002 90:42-5  DOI:10.1016/s0002-9149(02)02384-6  PMID:12088778
  • Stone, G. W., Moliterno, D. J., Bertrand, M., Neumann, F. J., Herrmann, H. C., Powers, E. R., Grines, C. L., Moses, J. W., Cohen, D. J., Cohen, E. A., Cohen, M., Wolski, K., et al. Impact of clinical syndrome acuity on the differential response to 2 glycoprotein IIb/IIIa inhibitors in patients undergoing coronary stenting: the TARGET Trial Circulation  2002 105:2347-2354  DOI:10.1161/01.cir.0000017635.82128.8c  PMID:12021219
  • Roffi, M., Moliterno, D. J., Meier, B., Powers, E. R., Grines, C. L., DiBattiste, P. M., Herrmann, H. C., Bertrand, M., Harris, K. E., Demopoulos, L. A., Topol, E. J., TARGET Investigators Impact of different platelet glycoprotein IIb/IIIa receptor inhibitors among diabetic patients undergoing percutaneous coronary intervention: Do Tirofiban and ReoPro Give Similar Efficacy Outcomes Trial (TARGET) 1-year follow-up Circulation  2002 105:2730-2736  DOI:10.1161/01.cir.0000018123.02672.c7  PMID:12057986
  • Robbins, M., Topol, E. J. Inflammation in acute coronary syndromes Cleveland Clinic Journal of Medicine  2002 69:130-142  PMID:12086253
  • Roffi, M., Mukherjee, D., Chew, D. P., Bhatt, D. L., Cho, L., Robbins, M. A., Ziada, K. M., Brennan, D. M., Ellis, S. G., Topol, E. J. Lack of benefit from intravenous platelet glycoprotein iib/iiia receptor inhibition as adjunctive treatment for percutaneous interventions of aortocoronary bypass grafts - a pooled analysis of five randomized clinical trials Circulation  2002 106:3063-3067  DOI:10.1161/01.cir.0000041250.89627.a9  PMID:12473552
  • Yoon, J., Wu, C. J., Homme, J., Tuch, R. J., Wolff, R. G., Topol, E. J., Lincoff, A. M. Local delivery of nitric oxide from an eluting stent to inhibit neointimal thickening in a porcine coronary injury model Yonsei Medical Journal  2002 43:242-251  PMID:11971219
  • Chan, A. W., Chew, D. P., Bhatt, D. L., Moliterno, D. J., Topol, E. J., Ellis, S. G. Long-term mortality benefit with the combination of stents and abciximab for cardiogenic shock complicating acute myocardial infarction American Journal of Cardiology  2002 89:132-136  DOI:10.1016/s0002-9149(01)02188-9  PMID:11792330
  • Wong, C. K., White, H. D., Wilcox, R. G., Criger, D. A., Califf, R. M., Topol, E. J., Ohman, E. M., GUSTO III Investigators Management and outcome of patients with atrial fibrillation during acute myocardial infarction: the GUSTO-III experience. Global use of strategies to open occluded coronary arteries Heart  2002 88:357-362  DOI:10.1136/heart.88.4.357  PMID:12231591  PMCID:PMC1767360
  • Bhatt, D. L., Bertrand, M. E., Berger, P. B., L'Allier, P. L., Moussa, I., Moses, J. W., Dangas, G., Taniuchi, M., Lasala, J. M., Holmes, D. R., Ellis, S. G., Topol, E. J. Meta-analysis of randomized and registry comparisons of ticlopidine with clopidogrel after stenting Journal of the American College of Cardiology  2002 39:9-14  DOI:10.1016/s0735-1097(01)01713-2  PMID:11755280
  • Mahaffey, K. W., Roe, M. T., Dyke, C. K., Newby, L. K., Kleiman, N. S., Connolly, P., Berdan, L. G., Sparapani, R., Lee, K. L., Armstrong, P. W., Topol, E. J., Califf, R. M., et al. Misreporting of myocardial infarction end points: Results of adjudication by a central clinical events committee in the paragon-b trial American Heart Journal  2002 143:242-248  DOI:10.1067/mhj.2002.120145  PMID:11835026
  • Lincoff, A. M., Califf, R. M., Van de Werf, F., Willerson, J. T., White, H. D., Armstrong, P. W., Guetta, V., Gibler, W. B., Hochman, J. S., Bode, C., Vahanian, A., Steg, P. G., et al. Mortality at 1 year with combination platelet glycoprotein iib/iiia inhibition and reduced-dose fibrinolytic therapy vs conventional fibrinolytic therapy for acute myocardial infarction - gusto v randomized trial JAMA-Journal of the American Medical Association  2002 288:2130-2135  DOI:10.1001/jama.288.17.2130  PMID:12413372
  • Chan, A. W., Quinn, M. J., Bhatt, D. L., Chew, D. P., Moliterno, D. J., Topol, E. J., Ellis, S. G. Mortality benefit of beta-blockade after successful elective percutaneous coronary intervention Journal of the American College of Cardiology  2002 40:669-675  DOI:10.1016/s0735-1097(02)02013-2  PMID:12204496
  • Topol, E. J., Lincoff, A. M., Kereiakes, D. J., Kleiman, N. S., Cohen, E. A., Ferguson, J. J., Tcheng, J. E., Sapp, S., Califf, R. M. Multi-year follow-up of abciximab therapy in three randomized, placebo-controlled trials of percutaneous coronary revascularization American Journal of Medicine  2002 113:1-6  DOI:10.1016/s0002-9343(02)01145-2  PMID:12106616
  • Dauterman, K., Topol, E. Optimal treatment and current situation in reperfusion after thrombolysis for acute myocardial infarction Annals of Medicine  2002 34:514-522  DOI:10.1080/078538902321117724  PMID:12553491
  • Mukherjee, D., Gurm, H., Tang, W. H. W., Roffi, M., Wolski, K., Moliterno, D. J., Guetta, V., Ardissinio, D., Bode, C., Steg, G., Lincoff, A. M., Topol, E. J. Outcome of acute, myocardial infarction in patients with prior coronary artery bypass grafting treated with combination reduced fibrinolytic therapy and abciximab American Journal of Cardiology  2002 90:1198-1203  DOI:10.1016/s0002-9149(02)02834-5  PMID:12450598
  • Moliterno, D. J., Yakubov, S. J., DiBattiste, P. M., Herrmann, H. C., Stone, G. W., Macaya, C., Neumann, F. J., Ardissino, D., Bassand, J. P., Borzi, L., Yeung, A. C., Harris, K. A., et al. Outcomes at 6 months for the direct comparison of tirofiban and abciximab during percutaneous coronary revascularisation with stent placement: The target follow-up study Lancet  2002 360:355-360  DOI:10.1016/s0140-6736(02)09605-8  PMID:12241774
  • Labinaz, M., Kilaru, R., Pieper, K., Marso, S. P., Kitt, M. M., Simoons, M. L., Califf, R. M., Topol, E. J., Armstrong, P. W., Harrington, R. A., Investigators, Pursuit Outcomes of patients with acute coronary syndromes and prior coronary artery bypass grafting - results from the platelet glycoprotein iib/iiia in unstable angina: Receptor suppression using integrilin therapy (pursuit) trial Circulation  2002 105:322-327  DOI:10.1161/hc0302.102578  PMID:11804987
  • Mehta, R. H., Criger, D. A., Granger, C. B., Pieper, K. K., Califf, R. M., Topol, E. J., Bates, E. R. Patient outcomes after fibrinolytic therapy for acute myocardial infarction at hospitals with and without coronary revascularization capability Journal of the American College of Cardiology  2002 40:1034-1040  DOI:10.1016/s0735-1097(02)02067-3  PMID:12354424
  • Rooner, E., Boersma, E., Akkerhuis, K. M., Harrington, R. A., Lincoff, A. M., Deckers, J. W., Karsch, K., Kleiman, N. S., Vahanian, A., Topol, E. J., Califf, R. M., Simoons, M. L. Patients with acute coronary syndromes without persistent st elevation undergoing percutaneous coronary intervention benefit most from early intervention with protection by a glycoprotein iib/iiia receptor blocker European Heart Journal  2002 23:239-246  DOI:10.1053/euhj.2001.2736  PMID:11792139
  • Gibler, W. B., Armstrong, P. W., Ohman, E. M., Weaver, W. D., Stebbins, A. L., Gore, J. M., Newby, L. K., Califf, R. M., Topol, E. J., Investigators, Gusto Persistence of delays in presentation and treatment for patients with acute myocardial infarction: The gusto-i and gusto-iii experience Annals of Emergency Medicine  2002 39:123-130  DOI:10.1067/mem.2002.121402  PMID:11823765
  • Mukherjee, D., Topol, E. J. Pharmacogenomics in cardiovascular diseases Progress in Cardiovascular Diseases  2002 44:479-498  DOI:10.1053/pcad.2002.123467  PMID:12077721
  • Roffi, M., Chew, D. P., Mukherjee, D., Bhatt, D. L., White, J. A., Moliterno, D. J., Heeschen, C., Hamm, C. W., Robbins, M. A., Kleiman, N. S., Theroux, P., White, H. D., et al. Platelet glycoprotein IIb/IIIa inhibition in acute coronary syndromes - gradient of benefit related to the revascularization strategy European Heart Journal  2002 23:1441-1448  DOI:10.1053/euhj.2002.3160  PMID:12208224
  • Quinn, M. J., Plow, E. F., Topol, E. J. Platelet glycoprotein IIb/IIIa inhibitors: recognition of a two-edged sword? Circulation  2002 106:379-385  DOI:10.1161/01.cir.0000019581.22812.b2  PMID:12119257
  • Boersma, E., Harrington, R. A., Moliterno, D. J., White, H., Theroux, P., Van de Werf, F., de Torbal, A., Armstrong, P. W., Wallentin, L. C., Wilcox, R. G., Simes, J., Califf, R. M., et al. Platelet glycoprotein iib/iiia inhibitors in acute coronary syndromes: A meta-analysis of all major randomised clinical trials Lancet  2002 359:189-198  DOI:10.1016/s0140-6736(02)07442-1  PMID:11812552
  • Lauer, M. A., Karweit, J. A., Cascade, E. F., Lin, N. D., Topol, E. J. Practice patterns and outcomes of percutaneous coronary interventions in the united states: 1995 to 1997 American Journal of Cardiology  2002 89:924-929  DOI:10.1016/s0002-9149(02)02240-3  PMID:11950429
  • Anderson, R. D., White, H. D., Ohman, E. M., Wagner, G. S., Krucoff, M. W., Armstrong, P. W., Weaver, W. D., Gibler, W. B., Stebbins, A. L., Califf, R. M., Topol, E. J. Predicting outcome after thrombolysis in acute myocardial infarction according to st-segment resolution at 90 minutes: A substudy of the gusto-iii trial American Heart Journal  2002 144:81-88  DOI:10.1067/mhj.2002.123319  PMID:12094192
  • Jeremias, A., Albirini, A., Ziada, K. M., Chew, D. P., Brener, S. J., Topol, E. J., Ellis, S. G. Prognostic significance of creatine kinase-mb elevation after percutaneous coronary intervention in patients with chronic renal dysfunction American Heart Journal  2002 143:1040-1045  DOI:10.1067/mhj.2002.122124  PMID:12075261
  • Cantor, W. J., Newby, L. K., Christenson, R. H., Tuttle, R. H., Hasselblad, V., Armstrong, P. W., Moliterno, D. J., Califf, R. M., Topol, E. J., Ohman, E. M., Investigators, Symphony, Investigators, 2nd Symphony Prognostic significance of elevated troponin i after percutaneous coronary intervention Journal of the American College of Cardiology  2002 39:1738-1744  DOI:10.1016/s0735-1097(02)01877-6  PMID:12039485
  • Mukherjee, D., Mahaffey, K. W., Moliterno, D. J., Harrington, R. A., Yadav, J. S., Pieper, K. S., Gallup, D., Dyke, C., Roe, M. T., Berdan, L., Lauer, M. S., Manttari, M., et al. Promise of combined low-molecular-weight heparin and platelet glycoprotein iib/iiia inhibition: Results from platelet iib/iiia antagonist for the reduction of acute coronary syndrome events in a global organization network b (paragon b) American Heart Journal  2002 144:995-1002  DOI:10.1067/mhj.2002.126118  PMID:12486423
  • Wang, K., Zhou, X. R., Zhou, Z. M., Tarakji, K., Qin, J. X., Sitges, M., Shiota, T., Forudi, F., Schaub, R. G., Kumar, A., Penn, M. S., Topol, E. J., et al. Recombinant soluble p-selectin glycoprotein ligand-ig (rpsgl-ig) attenuates infarct size and myeloperoxidase activity in a canine model of ischemia-reperfusion Thrombosis and Haemostasis  2002 88:149-154  PMID:12152656
  • Blankenship, J. C., Balog, C., Sapp, S. K., Califf, R. M., Lincoff, A. M., Tcheng, J. E., Topol, E. J. Reduction in vascular access site bleeding in sequential abciximab coronary intervention trials Catheterization and Cardiovascular Interventions  2002 57:476-483  DOI:10.1002/ccd.10322  PMID:12455081
  • Tamberella, M. R., Bhatt, D. L., Chew, D. P., Kereiakes, D. J., Topol, E. J., Steinhubl, S. R., Investigators, Gold Relation of platelet inactivation with intravenous glycoprotein iib/iiia antagonists to major bleeding (from the gold study) American Journal of Cardiology  2002 89:1429-1431  DOI:10.1016/s0002-9149(02)02362-7  PMID:12062743
  • Jeremias, A., Bhatt, D. L., Chew, D. P., Ziada, K. M., Albirini, A., Brener, S. J., Lincoff, M., Topol, E. J., Ellis, S. G. Safety of abciximab during percutaneous coronary intervention in patients with chronic renal insufficiency American Journal of Cardiology  2002 89:1209-1211  DOI:10.1016/s0002-9149(02)02308-1  PMID:12008179
  • Al-Khatib, S. M., Granger, C. B., Huang, Y., Lee, K. L., Califf, R. M., Simoons, M. L., Armstrong, P. W., Van de Werf, F., White, H. D., Simes, R. J., Moliterno, D. J., Topol, E. J., et al. Sustained ventricular arrhythmias among patients with acute coronary syndromes with no st-segment elevation - incidence, predictors, and outcomes Circulation  2002 106:309-312  DOI:10.1161/01.cir.0000022692.49934.e3  PMID:12119245
  • Lee, M. S., Wali, A. U., Menon, V., Berkowitz, S. D., Thompson, T. D., Califf, R. M., Topol, E. J., Granger, C. B., Hochman, J. S. The determinants of activated partial thromboplastin time, relation of activated partial thromboplastin time to clinical outcomes, and optimal dosing regimens for heparin treated patients with acute coronary syndromes: A review of gusto-iib Journal of Thrombosis and Thrombolysis  2002 14:91-101  DOI:10.1023/a:1023235926825  PMID:12714828
  • Savonitto, S., Granger, C. B., Ardissino, D., Gardner, L., Cavallini, C., Galvani, M., Ottani, F., White, H. D., Armstrong, P. W., Ohman, E. M., Pieper, K. S., Califf, R. M., et al. The prognostic value of creatine kinase elevations extends across the whole spectrum of acute coronary syndromes Journal of the American College of Cardiology  2002 39:22-29  DOI:10.1016/s0735-1097(01)01706-5  PMID:11755282
  • Mukherjee, D., Topol, E. J. The role of low-molecular-weight heparin in cardiovascular diseases Progress in Cardiovascular Diseases  2002 45:139-156  DOI:10.1053/pcad.2002.127679  PMID:12411975
  • Aviles, R. J., Askari, A. T., Lindahl, B., Wallentin, L., Jia, G., Ohman, E. M., Mahaffey, K. W., Newby, L. K., Califf, R. M., Simoons, M. L., Topol, E. J., Lauer, M. S., et al. Troponin t levels in patients with acute coronary syndromes, with or without renal dysfunction New England Journal of Medicine  2002 346:2047-2052  DOI:10.1056/NEJMoa013456  PMID:12087140
  • Lincoff, A. M., Kereiakes, D. J., Mascelli, M. A., Deckelbaum, L. I., Barnathan, E. S., Patel, K. K., Frederick, B., Nakada, M. T., Topol, E. J. Abciximab suppresses the rise in levels of circulating inflammatory markers after percutaneous coronary revascularization Circulation  2001 104:163-167  PMID:11447080
  • Zhang, Z. L., Brennan, M. L., Fu, X. M., Aviles, R. J., Pearce, G. L., Penn, M. S., Topol, E. J., Sprecher, D. L., Hazen, S. L. Association between myeloperoxidase levels and risk of coronary artery disease JAMA-Journal of the American Medical Association  2001 286:2136-2142  PMID:11694155
  • Al-Khatib, S. M., Pieper, K. S., Lee, K. L., Mahaffey, K. W., Hochman, J. S., Pepine, C. J., Kopecky, S. L., Akkerhuis, M., Stepinska, J., Simoons, M. L., Topol, E. J., Califf, R. M., et al. Atrial fibrillation and mortality among patients with acute coronary syndromes without st-segment elevation: Results from the pursuit trial American Journal of Cardiology  2001 88:76-79  DOI:10.1016/s0002-9149(01)01593-4
  • Lauer, M. A., Houghtaling, P. L., Peterson, J. G., Granger, C. B., Bhatt, D. L., Sapp, S. K., Simoons, M. L., Harrington, R. A., Topol, E. J., Lincoff, A. M. Attenuation of rebound ischemia after discontinuation of heparin therapy by glycoprotein iib/iiia inhibition with eptifibatide in patients with acute coronary syndromes - observations from the platelet iib/iiia in unstable angina: Receptor suppression using integrilin therapy (pursuit) trial Circulation  2001 104:2772-2777  DOI:10.1161/hc4801.100358  PMID:11733393
  • Newby, L. K., Ohman, E. M., Christenson, R. H., Moliterno, D. J., Harrington, R. A., White, H. D., Armstrong, P. W., Van de Werf, F., Pfisterer, M., Hasselblad, V., Califf, R. M., Topol, E. J., et al. Benefit of glycoprotein iib/iiia inhibition in patients with acute coronary syndromes and troponin t-positive status - the paragon-b troponin t substudy Circulation  2001 103:2891-2896  DOI:10.1161/‚Äã01.CIR.103.24.2891  PMID:11413076
  • Bittl, J. A., Chaitman, B. R., Feit, F., Kimball, W., Topol, E. J., Bivalirudin Angioplasty Study, Inv Bivalirudin versus heparin during coronary angioplasty for unstable or postinfarction angina: Final report reanalysis of the bivalirudin angioplasty study American Heart Journal  2001 142:952-959  DOI:10.1067/mhj.2001.119374  PMID:11717596
  • Patel, V. B., Robbins, M. A., Topol, E. J. C-reactive protein: A 'golden marker' for inflammation and coronary artery disease Cleveland Clinic Journal of Medicine  2001 68:521-524, 527  PMID:11405613
  • Roe, M. T., Granger, C. B., Puma, J. A., Hellkamp, A. S., Hochman, J. S., Ohman, E. M., White, H. D., Van de Werf, F., Armstrong, P. W., Ellis, S. G., Califf, R. M., Topol, E. J. Comparison of benefits and complications of hirudin versus heparin for patients with acute coronary syndromes undergoing early percutaneous coronary intervention American Journal of Cardiology  2001 88:1403-6, A6  DOI:10.1016/s0002-9149(01)02119-1  PMID:11741559
  • Topol, E. J., Moliterno, D. J., Herrmann, H. C., Powers, E. R., Grines, C. L., Cohen, D. J., Cohen, E. A., Bertrand, M., Neumann, F. J., Stone, G. W., DiBattiste, P. M., Demopoulos, L., et al. Comparison of two platelet glycoprotein IIb/IIIa inhibitors, tirofiban and abciximab, for the prevention of ischemic events with percutaneous coronary revascularization New England Journal of Medicine  2001 344:1888-1894  DOI:10.1056/nejm200106213442502  PMID:11419425
  • Chew, D. P., Bhatt, D. L., Lincoff, A. M., Moliterno, D. J., Brener, S. J., Wolski, K. E., Topol, E. J. Defining the optimal activated clotting time during percutaneous coronary intervention - aggregate results from 6 randomized, controlled trials Circulation  2001 103:961-966  PMID:11181470
  • Mahaffey, K. W., Harrington, R. A., Akkerhuis, M., Kleiman, N. S., Berdan, L. G., Crenshaw, B. S., Tardiff, B. E., Granger, C. B., DeJong, I., Bhapkar, M., Widimsky, P., Corbalon, R., et al. Disagreements between central clinical events committee and site investigator assessments of myocardial infarction endpoints in an international clinical trial: Review of the pursuit study Current Controlled Trials in Cardiovascular Medicine  2001 2:187-194  DOI:10.1186/cvm-2-4-187  PMID:11806794  PMCID:PMC57750
  • Hudson, M. P., Granger, C. B., Topol, E. J., Pieper, K. S., Armstrong, P. W., Barbash, G. I., Guerci, A. D., Vahanian, A., Califf, R. M., Ohman, E. M. Early reinfarction after fibrinolysis - experience from the global utilization of streptokinase and tissue plasminogen activator (alteplase) for occluded coronary arteries (gusto i) and global use of strategies to open occluded coronary arteries (gusto iii) trials Circulation  2001 104:1229-1235  DOI:10.1161/hc3601.095717  PMID:11551872
  • Chew, D. P., Bhatt, D. L., Robbins, M. A., Mukherjee, D., Roffi, M., Schneider, J. P., Topol, E. J., Ellis, S. G. Effect of clopidogrel added to aspirin before percutaneous coronary intervention on the risk associated with c-reactive protein American Journal of Cardiology  2001 88:672-674  DOI:10.1016/s0002-9149(01)01813-6  PMID:11564394
  • Aronow, H. D., Topol, E. J., Roe, M. T., Houghtaling, P. L., Wolski, K. E., Lincoff, A. M., Harrington, R. A., Califf, R. M., Ohman, E. M., Kleiman, N. S., Keltai, M., Wilcox, R. G., et al. Effect of lipid-lowering therapy on early mortality after acute coronary syndromes: An observational study Lancet  2001 357:1063-1068  DOI:10.1016/s0140-6736(00)04257-4  PMID:11297956
  • Cho, L., Bhatt, D. L., Wolski, K., Lincoff, M., Topol, E. J., Moliterno, D. Effect of smoking status and abciximab use on outcome after percutaneous coronary revascularisation: Pooled analysis from epic, epilog, and epistent American Heart Journal  2001 141:599-602  DOI:10.1067/mhj.2001.113573  PMID:11275926
  • Chew, D. P., Bhatt, D. L., Sapp, S., Topol, E. J. Increased mortality with oral platelet glycoprotein IIb/IIIa antagonists: a meta-analysis of phase III multicenter randomized trials Circulation  2001 103:201-206  PMID:11208677
  • Chew, D. P., Bhatt, D. L., Robbins, M. A., Penn, M. S., Schneider, J. P., Lauer, M. S., Topol, E. J., Ellis, S. G. Incremental prognostic value of elevated baseline c-reactive protein among established markers of risk in percutaneous coronary intervention Circulation  2001 104:992-997  DOI:10.1161/hc3401.095074  PMID:11524391
  • Chew, D. P., Roffi, M., Topol, E. J. Intravenous glycoprotein iib/iiia inhibition in non-st segment elevation acute coronary syndromes Progress in Cardiovascular Diseases  2001 44:195-206  DOI:10.1053/pcad.2001.29143  PMID:11727277
  • Anderson, K. M., Califf, R. M., Stone, G. W., Neumann, F. J., Montalescot, G., Miller, D. P., Ferguson, J. J., Willerson, J. T., Weisman, H. F., Topol, E. J. Long-term mortality benefit with abciximab in patients undergoing percutaneous coronary intervention Journal of the American College of Cardiology  2001 37:2059-2065  DOI:10.1016/s0735-1097(01)01290-6  PMID:11419888
  • Park, S. H., Marso, S. P., Zhou, Z. M., Foroudi, F., Topol, E. J., Lincoff, A. M. Neointimal hyperplasia after arterial injury is increased in a rat model of non-insulin-dependent diabetes mellitus Circulation  2001 104:815-819  DOI:10.1161/hc3301.092789  PMID:11502708
  • Labinaz, M., Sketch, M. H., Ellis, S. G., Abramowitz, B. M., Stebbins, A. L., Pieper, K. S., Holmes, D. R., Califf, R. M., Topol, E. J. Outcome of acute st-segment elevation myocardial infarction in patients with prior coronary artery bypass surgery receiving thrombolytic therapy American Heart Journal  2001 141:469-477  DOI:10.1067/mhj.2001.112779  PMID:11231447
  • Roffi, M., Chew, D. P., Mukherjee, D., Bhatt, D. L., White, J. A., Heeschen, C., Hamm, C. W., Moliterno, D. J., Califf, R. A., White, H. D., Kleiman, N. S., Theroux, P., et al. Platelet glycoprotein iib/iiia inhibitors reduce mortality in diabetic patients with non-st-segment-elevation acute coronary syndromes Circulation  2001 104:2767-2771  DOI:10.1161/hc4801.100029  PMID:11733392
  • Cura, F. A., L'Allier, P. L., Kapadia, S. R., Houghtaling, P. L., Dipaola, L. M., Ellis, S. G., Topol, E. J., Brener, S. J., IIb, Gusto, Investigator, Rapport Predictors and prognosis of suboptimal coronary blood flow after primary coronary angioplasty in patients with acute myocardial infarction American Journal of Cardiology  2001 88:124-128  DOI:10.1016/s0002-9149(01)01605-8  PMID:11448407
  • Lundergan, C. F., Ross, A. M., McCarthy, W. F., Reiner, J. S., Boyle, D., Fink, C., Califf, R. M., Topol, E. J., Simoons, M. L., Van Den Brand, M., Van de Werf, F., Coyne, K. S. Predictors of left ventricular function after acute myocardial infarction: Effects of time to treatment potency, and body mass index - the gusto-i angiographic experience American Heart Journal  2001 142:43-50  DOI:10.1067/mhj.2001.116076  PMID:11431655
  • Wang, K., Zhou, Z. M., Zhou, X. R., Tarakji, K., Topol, E. J., Lincoff, A. M. Prevention of intimal hyperplasia with recombinant soluble p-selectin glycoprotein ligand-immunoglobulin in the porcine coronary artery balloon injury model Journal of the American College of Cardiology  2001 38:577-582  DOI:10.1016/s0735-1097(01)01347-x  PMID:11499755
  • Gum, P. A., Kottke-Marchant, K., Poggio, E. C., Gurm, H., Welsh, P. A., Brooks, L., Sapp, S. K., Topol, E. J. Profile and prevalence of aspirin resistance in patients with cardiovascular disease American Journal of Cardiology  2001 88:230-235  DOI:10.1016/s0002-9149(01)01631-9  PMID:11472699
  • Peterson, J. G., Topol, E. J., Roe, M. T., Sapp, S. K., Lincoff, A. M., Deckers, J. W., Blackstone, E. H., Harrington, R. A., Califf, R. M., Lauer, M. S., Investigators, Pursuit Prognostic importance of concomitant heparin with eptifibatide in acute coronary syndromes American Journal of Cardiology  2001 87:532-536  DOI:10.1016/s0002-9149(00)01426-0  PMID:11230834
  • Kaul, P., Fu, Y. L., Chang, W. C., Harrington, R. A., Wagner, G. S., Goodman, S. G., Granger, C. B., Moliterno, D. J., Van de Werf, F., Califf, R. N., Topol, E. J., Armstrong, P. W., et al. Prognostic value of st segment depression in acute coronary syndromes: Insights from paragon-a applied to gusto-iib Journal of the American College of Cardiology  2001 38:64-71  DOI:10.1016/s0735-1097(01)01307-9  PMID:11451297
  • Bahit, M. C., Topol, E. J., Califf, R. M., Armstrong, P. W., Criger, D. A., Hasselblad, V., Betriu, A., Hirsh, J., Ardissino, D., Granger, C. B. Reactivation of ischemic events in acute coronary syndromes: Results from gusto-iib Journal of the American College of Cardiology  2001 37:1001-1007  DOI:10.1016/s0735-1097(01)01143-3  PMID:11263599
  • Topol, E. Recent advances in anticoagulant therapy for acute coronary syndromes American Heart Journal  2001 142:S22-S29  DOI:10.1067/mhj.2001.117034  PMID:11479487
  • Pilote, L., Miller, D. P., Califf, L. M., Topol, E. J., Investigators, Gusto- I. Recurrent ischemia after thrombolysis for acute myocardial infarction American Heart Journal  2001 141:559-565  DOI:10.1067/mhj.2001.113226  PMID:11275920
  • Topol, E. J., Califf, R. M., Van de Werf, F., Willerson, J. T., Booth, J., White, H., Clayman, M., Deckelbaum, L., Lincoff, A. M., Ohman, E. M., Bates, E., Gibler, W. B., et al. Reperfusion therapy for acute myocardial infarction with fibrinolytic therapy or combination reduced fibrinolytic therapy and platelet glycoprotein iib/iiia inhibition: The gusto randomised trial Lancet  2001 357:1905-1914  PMID:11425410
  • Mukherjee, D., Nissen, S. E., Topol, E. J. Risk of cardiovascular events associated with selective cox-2 inhibitors JAMA-Journal of the American Medical Association  2001 286:954-959  DOI:10.1001/jama.286.8.954  PMID:11509060
  • Akkerhuis, K. M., Deckers, J. W., Lincoff, A. M., Tcheng, J. E., Boersma, E., Anderson, K., Balog, C., Califf, R. M., Topol, E. J., Simoons, M. L. Risk of stroke associated with abciximab among patients undergoing percutaneous coronary intervention JAMA-Journal of the American Medical Association  2001 286:78-82  DOI:10.1001/jama.286.1.78  PMID:11434830
  • Topol, E. J., McCarthy, J., Gabriel, S., Moliterno, D. J., Rogers, W. J., Newby, L. K., Freedman, M., Metivier, J., Cannata, R., O'Donnell, C. J., Kottke-Marchant, K., Murugesan, G., et al. Single nucleotide polymorphisms in multiple novel thrombospondin genes may be associated with familial premature myocardial infarction Circulation  2001 104:2641-2644  DOI:10.1161/hc4701.100910  PMID:11723011
  • Bhatt, D. L., Chew, D. P., Hirsch, A. T., Ringleb, P. A., Hacke, W., Topol, E. J. Superiority of clopidogrel versus aspirin in patients with prior cardiac surgery Circulation  2001 103:363-368  PMID:11157686
  • Mahaffey, K. W., Harrington, R. A., Akkerhuis, M., Kleiman, N. S., Berdan, L. G., Crenshaw, B. S., Tardiff, B. E., Granger, C. B., DeJong, I., Bhapkar, M., Widimsky, P., Corbalon, R., et al. Systematic adjudication of myocardial infarction end-points in an international clinical trial Current Controlled Trials in Cardiovascular Medicine  2001 2:180-186  DOI:10.1186/cvm-2-4-180  PMID:11806793  PMCID:PMC57749
  • Greenbaum, A. B., Harrington, R. A., Hudson, M. P., MacAulay, C. M., Wilcox, R. G., Simoons, M. L., Berdan, L. G., Guerci, A., Cokkinos, D. V., Kitt, M. M., Lincoff, A. M., Topol, E. J., et al. Therapeutic value of eptifibatide at community hospitals transferring patients to tertiary referral centers early after admission for acute coronary syndromes Journal of the American College of Cardiology  2001 37:492-498  DOI:10.1016/s0735-1097(00)01143-8  PMID:11216968
  • White, H. D., Simes, R. J., Aylward, P. E. G., Armstrong, P. W., Califf, R. M., French, J. K., Granger, C. B., Marschner, I. C., Topol, E. J., Van de Werf, F. J., Wilcox, R. G., Hirulog Early Reperfusion, Occlusi Thrombin-specific anticoagulation with bivalirudin versus heparin in patients receiving fibrinolytic therapy for acute myocardial infarction: The hero-2 randomised trial Lancet  2001 358:1855-1863  PMID:11741625
  • Steinhubl, S. R., Ellis, S. G., Wolski, K., Lincoff, A. M., Topol, E. J., Investigators, Epistent Ticlopidine pretreatment before coronary stenting is associated with sustained decrease in adverse cardiac events - data from the evaluation of platelet iib/iiia inhibitor for stenting (epistent) trial Circulation  2001 103:1403-1409  PMID:11245644
  • Barbash, G. I., Birnbaum, Y., Bogaerts, K., Hudson, M., Lesaffre, E., Fu, Y. L., Goodman, S., Houbracken, K., Munsters, K., Granger, C. B., Pieper, K., Califf, R. M., et al. Treatment of reinfarction after thrombolytic therapy for acute myocardial infarction - an analysis of outcome and treatment choices in the global utilization of streptokinase and tissue plasminogen activator for occluded coronary arteries (gusto i) and assessment of the safety of a new thrombolytic (assent 2) studies Circulation  2001 103:954-960  PMID:11181469
  • Cohen, M. G., Pacchiana, C. M., Corbalan, R., Perez, J. E. I., Ponte, C. I., Oropeza, E. S., Diaz, R., Paolasso, E., Izasa, D., Rodas, M. A., Urrutia, C. E., Harrington, R. A., et al. Variation in patient management and outcomes for acute coronary syndromes in latin america and north america: Results from the platelet iib/iiia in unstable angina: Receptor suppression using integrilin therapy (pursuit) trial American Heart Journal  2001 141:391-401  DOI:10.1067/mhj.2001.113216  PMID:11231436
  • Batchelor, W. B., Granger, C. B., Kleiman, N. S., Phillips, H. R., Ellis, S. G., Betriu, A., Criger, D. A., Stebbins, A. L., Topol, E. J., Califf, R. M., Investigators, Gusto IIb A comparison of ionic versus nonionic contrast medium during primary percutaneous transluminal coronary angioplasty for acute myocardial infarction (gusto iib) American Journal of Cardiology  2000 85:692-697  DOI:10.1016/s0002-9149(99)00842-5  PMID:12000041
  • Moliterno, D. J., Topol, E. J., TARGET International Steering Committee A direct comparison of tirofiban and abciximab during percutaneous coronary revascularization and stent placement: rationale and design of the TARGET study American Heart Journal  2000 140:722-726  DOI:10.1067/mhj.2000.110094  PMID:11054616
  • Lincoff, A. M., LeNarz, L. A., Despotis, G. J., Smith, P. K., Booth, J. E., Raymond, R. E., Sapp, S. K., Cabot, C. F., Tcheng, J. E., Califf, R. M., Effron, M. B., Topol, E. J., et al. Abciximab and bleeding during coronary surgery: Results from the epilog and epistent trials Annals of Thoracic Surgery  2000 70:516-526  DOI:10.1016/s0003-4975(00)01343-6  PMID:10969673
  • Bhatt, D. L., Marso, S. P., Lincoff, A. M., Wolski, K. E., Ellis, S. G., Topol, E. J. Abciximab reduces mortality in diabetics following percutaneous coronary intervention Journal of the American College of Cardiology  2000 35:922-928  DOI:10.1016/s0735-1097(99)00650-6  PMID:10732889
  • Hasdai, D., Holmes, D. R., Criger, D. A., Topol, E. J., Califf, R. M., Harrington, R. A., Pursuit Trial ,Investigators Age and outcome after acute coronary syndromes without persistent st-segment elevation American Heart Journal  2000 139:858-866  DOI:10.1016/s0002-8703(00)90018-8  PMID:10783220
  • Bhatt, D. L., Topol, E. J. Antiplatelet and anticoagulant therapy in the secondary prevention of ischemic heart disease Medical Clinics of North America  2000 84:163-179, ix  DOI:10.1016/s0025-7125(05)70212-1  PMID:10685133
  • Bruce, C. J., Kuntz, R. E., Popma, J. J., Pieper, K. S., Topol, E. J., Holmes, D. R. Application of a continuous regression model of restenosis to saphenous vein grafts after successful percutaneous transluminal coronary angioplasty or directional coronary atherectomy Journal of the American College of Cardiology  2000 35:619-623  DOI:10.1016/s0735-1097(99)00595-1  PMID:10716463
  • Alexander, J. H., Sparapani, R. A., Mahaffey, K. W., Deckers, J. W., Newby, L. K., Ohman, E. M., Corbalan, R., Chierchia, S. L., Boland, J. B., Simoons, M. L., Califf, R. M., Topol, E. J., et al. Association between minor elevations of creatine kinase-mb level and mortality in patients with acute coronary syndromes without st-segment elevation JAMA-Journal of the American Medical Association  2000 283:347-353  DOI:10.1001/jama.283.3.347  PMID:10647797
  • Fu, Y. L., Chang, W. C., Mark, D., Califf, R. M., Mackenzie, B., Granger, C. B., Topol, E. J., Hlatky, M., Armstrong, P. W., Investigators, Gusto IIb Canadian-american differences in the management of acute coronary syndromes in the gusto iib trial - one-year follow-up of patients without st-segment elevation Circulation  2000 102:1375-1381  PMID:10993855
  • Hasdai, D., Topol, E. J., Califf, R. M., Berger, P. B., Holmes, D. R. Cardiogenic shock complicating acute coronary syndromes Lancet  2000 356:749-756  DOI:10.1016/s0140-6736(00)02640-4  PMID:11085707
  • Topol, E. J. Cardiology in the 21st century European Heart Journal Supplements  2000 2:E18-E27
  • Hasdai, D., Holmes, D. R., Criger, D. A., Topol, E. J., Califf, R. M., Wilcox, R. G., Paolasso, E., Simoons, M., Deckers, J., Harrington, R. A., investigators, Pursuit trial Cigarette smoking status and outcome among patients with acute coronary syndromes without persistent st-segment elevation: Effect of inhibition of platelet glycoprotein iib/iiia with eptifibatide American Heart Journal  2000 139:454-460  DOI:10.1067/mhj.2000.103847  PMID:10689260
  • Roe, M. T., Harrington, R. A., Prosper, D. M., Pieper, K. S., Bhatt, D. L., Lincoff, A. M., Simoons, M. L., Akkerhuis, M., Ohman, E. M., Kitt, M. M., Vahanian, A., Ruzyllo, W., et al. Clinical and therapeutic profile of patients presenting with acute coronary syndromes who do not have significant coronary artery disease Circulation  2000 102:1101-1106  PMID:10973837
  • Cho, L., Topol, E. J., Balog, C., Foody, J. M., Booth, J. E., Cabot, C., Kleiman, N. S., Tcheng, J. E., Califf, R., Lincoff, M. A. Clinical benefit of glycoprotein iib/iiia blockade with abciximab is independent of gender - pooled analysis from epic, epilog and epistent trials Journal of the American College of Cardiology  2000 36:381-386  DOI:10.1016/s0735-1097(00)00746-4  PMID:10933346
  • Kereiakes, D. J., Berkowitz, S. D., Lincoff, A. M., Tcheng, J. E., Wolski, K., Achenbach, R., Melsheimer, R., Anderson, K., Califf, R. M., Topol, E. J. Clinical correlates and course of thrombocytopenia during percutaneous coronary intervention in the era of abciximab platelet glycoprotein iib/iiia blockade American Heart Journal  2000 140:74-80  DOI:10.1067/mhj.2000.106615  PMID:10874266
  • Topol, C. E., Califf, R. M., Simes, R. J., Van de Werf, F., Diaz, R., Paolasso, E., Aylward, P. E., Keech, A., Klein, W., Piegas, L., Tomov, I., Armstrong, P. W., et al. Comparison of sibrafiban with aspirin for prevention of cardiovascular events after acute coronary syndromes: A randomised trial Lancet  2000 355:337-345  PMID:10665552
  • Newby, L. K., Eisenstein, E. L., Califf, R. M., Thompson, T. D., Nelson, C. L., Peterson, E. D., Armstrong, P. W., Van de Werf, F., White, H. D., Topol, E. J., Mark, D. B. Cost effectiveness of early discharge after uncomplicated acute myocardial infarction New England Journal of Medicine  2000 342:749-755  DOI:10.1056/nejm200003163421101  PMID:10717009
  • Mark, D. B., Harrington, R. A., Lincoff, A. M., Califf, R. M., Nelson, C. L., Tsiatis, A. A., Buell, H., Mahaffey, K. W., Davidson-Ray, L., Topol, E. J. Cost-effectiveness of platelet glycoprotein IIb/IIIa inhibition with eptifibatide in patients with non-ST-elevation acute coronary syndromes Circulation  2000 101:366-371  PMID:10653826
  • Bhatt, D. L., Topol, E. J. Current role of platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes JAMA-Journal of the American Medical Association  2000 284:1549-1558  DOI:10.1001/jama.284.12.1549  PMID:11000650
  • Gebel, J. M., Brott, T. G., Sila, C. A., Tomsick, T. A., Jauch, E., Salisbury, S., Khoury, J., Miller, R., Pancioli, A., Duldner, J. E., Topol, E. J., Broderick, J. P. Decreased perihematomal edema in thrombolysis-related intracerebral hemorrhage compared with spontaneous intracerebral hemorrhage Stroke  2000 31:596-600  PMID:10700491
  • Topol, E. J., Easton, J. D., Amarenco, P., Califf, R., Harrington, R., Graffagnino, C., Davis, S., Diener, H. C., Ferguson, J., Fitzgerald, D., Shuaib, A., Koudstaal, P. J., et al. Design of the blockade of the glycoprotein iib/iiia receptor to avoid vascular occlusion (bravo) trial American Heart Journal  2000 139:927-933  DOI:10.1067/mhj.2000.105107  PMID:10827369
  • Hasdai, D., Granger, C. B., Srivatsa, S. S., Criger, D. A., Ellis, S. G., Califf, R. M., Topol, E. J., Holmes, D. R. Diabetes mellitus and outcome after primary coronary angioplasty for acute myocardial infarction: Lessons from the gusto-iib angioplasty substudy Journal of the American College of Cardiology  2000 35:1502-1512  DOI:10.1016/s0735-1097(00)00591-x  PMID:10807453
  • Harrington, R. A., Armstrong, P. W., Graffagnino, C., Van de Werf, F., Kereiakes, D. J., Sigmon, K. N., Card, T., Joseph, D. M., Samuels, R., Granett, J., Chan, R., Califf, R. M., et al. Dose-finding, safety, and tolerability study of an oral platelet glycoprotein IIb/IIIa inhibitor, lotrafiban, in patients with coronary or cerebral atherosclerotic disease Circulation  2000 102:728-735  PMID:10942739
  • Kleiman, N. S., Lincoff, A. M., Flaker, G. C., Pieper, K. S., Wilcox, R. G., Berdan, L. G., Lorenz, T. J., Cokkinos, D. V., Simoons, M. L., Boersma, E., Topol, E. J., Califf, R. M., et al. Early percutaneous coronary intervention, platelet inhibition with eptifibatide, and clinical outcomes in patients with acute coronary syndromes Circulation  2000 101:751-757  PMID:10683348
  • Lincoff, A. M., Mark, D. B., Tcheng, J. E., Califf, R. M., Bala, M. V., Anderson, K. M., Davidson-Ray, L., Knight, J. D., Cabot, C. F., Topol, E. J., Investigators, Epilog Economic assessment of platelet glycoprotein iib/iiia receptor blockade with abciximab and low-dose heparin during percutaneous coronary revascularization - results from the epilog randomized trial Circulation  2000 102:2923-2929  PMID:11113041
  • Mak, K. H., Topol, E. J. Emerging concepts in the management of acute myocardial infarction in patients with diabetes mellitus Journal of the American College of Cardiology  2000 35:563-568  DOI:10.1016/s0735-1097(99)00628-2  PMID:10716456
  • Marso, S. P., Bhatt, D. L., Roe, M. T., Houghtaling, P. L., Labinaz, M., Kleiman, N. S., Dyke, C., Simmoons, M. L., Califf, R. M., Harrington, R. A., Topol, E. J., Investigators, Pursuit Enhanced efficacy of eptifibatide administration in patients with acute coronary syndrome requiring in-hospital coronary artery bypass grafting Circulation  2000 102:2952-2958  PMID:11113045
  • Peterson, J. G., Topol, E. J., Sapp, S. K., Young, J. B., Lincoff, A. M., Lauer, M. S. Evaluation of the effects of aspirin combined with angiotensin-converting enzyme inhibitors in patients with coronary artery disease American Journal of Medicine  2000 109:371-377  DOI:10.1016/s0002-9343(00)00492-7  PMID:11020393
  • Herrmann, H. C., Moliterno, D. J., Ohman, E. M., Stebbins, A. L., Bode, C., Betriu, A., Forycki, F., Miklin, J. S., Bachinsky, W. B., Lincoff, A. M., Califf, R. M., Topol, E. J. Facilitation of early percutaneous coronary intervention after reteplase with or without abciximab in acute myocardial infarction - results from the speed (gusto-4 pilot) trial Journal of the American College of Cardiology  2000 36:1489-1496  DOI:10.1016/s0735-1097(00)00923-2  PMID:11079647
  • Akkerhuis, K. M., Deckers, J. W., Boersma, E., Harrington, R. A., Stepinska, J., Mahaffey, K. W., Wilcox, R. G., Lincoff, A. M., Keltai, M., Topol, E. J., Califf, R. M., Simoons, M. L., et al. Geographic variability in outcomes within an international trial of glycoprotein iib/iiia inhibition in patients with acute coronary syndromes - results from pursuit European Heart Journal  2000 21:371-381  DOI:10.1053/euhj.1999.1743  PMID:10666351
  • Brieger, D. B., Mak, K. H., Miller, D. P., Califf, R. M., Topol, E. J., Investigators, Gusto- I. Hierarchy of risk based on history and location of prior myocardial infarction in the thrombolytic era American Heart Journal  2000 140:29-33  DOI:10.1067/mhj.2000.106166  PMID:10874260
  • Yamada, D. M., Topol, E. J. Importance of microembolization and inflammation in atherosclerotic heart disease American Heart Journal  2000 140:S90-S102  DOI:10.1067/mhj.2000.111611  PMID:11100003
  • Topol, E. J. Inflammation and embolization in ischemic heart disease Journal of Invasive Cardiology  2000 12:2B-7B  PMID:10731293
  • McGuire, D. K., Emanuelsson, H., Granger, C. B., Ohman, E. M., Moliterno, D. J., White, H. D., Ardissino, D., Box, J. W., Califf, R. M., Topol, E. J., Investigators, G. USTO-IIb Influence of diabetes mellitus on clinical outcomes across the spectrum of acute coronary syndromes - findings from the gusto-iib study European Heart Journal  2000 21:1750-1758  DOI:10.1053/euhj.2000.2317  PMID:11052839
  • Kleiman, N. S., Tracy, R. P., Talley, J. D., Sigmon, K., Joseph, D., Topol, E. J., Califf, R. M., Kitt, M., Ohman, E. M. Inhibition of platelet aggregation with a glycoprotein IIb-IIIa antagonist does not prevent thrombin generation in patients undergoing thrombolysis for acute myocardial infarction Journal of Thrombosis and Thrombolysis  2000 9:5-12  DOI:10.1023/a:1018650123272  PMID:10590183
  • Menon, V., Hochman, J. S., Stebbins, A., Pfisterer, M., Col, J., Anderson, R. D., Hasdai, D., Holmes, D. R., Bates, E. R., Topol, E. J., Califf, R. M., Ohman, E. M., et al. Lack of progress in cardiogenic shock: Lessons from the gusto trials European Heart Journal  2000 21:1928-1936  DOI:10.1053/euhj.2000.2240  PMID:11071798
  • Lincoff, A. M., Harrington, R. A., Califf, R. M., Hochman, J. S., Guerci, A. D., Ohman, E. M., Pepine, C. J., Kopecky, S. L., Kleiman, N. S., Pacchiana, C. M., Berdan, L. G., Kitt, M. M., et al. Management of patients with acute coronary syndromes in the united states by platelet glycoprotein iib/iiia inhibition - insights from the platelet glycoprotein iib/iiia in unstable angina: Receptor suppression using integrilin therapy (pursuit) trial Circulation  2000 102:1093-1100  PMID:10973836
  • Sgarbossa, E. B., Meyer, P. M., Pinski, S. L., Pavlovic-Surjancev, B., Barbagelata, A., Goodman, S. G., Lum, A. S., Underwood, D. A., Gates, K. B., Califf, R. M., Topol, E. J., Wagner, G. S. Negative t waves shortly after st-elevation acute myocardial infarction are a powerful marker for improved survival rate American Heart Journal  2000 140:385-394  DOI:10.1067/mhj.2000.108835  PMID:10966535
  • Wong, C. K., White, H. D., Wilcox, R. G., Criger, D. A., Califf, R. M., Topol, E. J., Ohman, E. M., GUSTO III Investigators New atrial fibrillation after acute myocardial infarction independently predicts death: the GUSTO-III experience American Heart Journal  2000 140:878-885  DOI:10.1067/mhj.2000.111108  PMID:11099991
  • Sane, D. C., Damaraju, L. V., Topol, E. J., Cabot, C. F., Mascelli, M. A., Harrington, R. A., Simoons, M. L., Califf, R. M. Occurrence and clinical significance of pseudothrombocytopenia during abciximab therapy Journal of the American College of Cardiology  2000 36:75-83  DOI:10.1016/s0735-1097(00)00688-4  PMID:10898416
  • Cho, L., Marso, S. P., Bhatt, D. L., Topol, E. J. Optimizing percutaneous coronary revascularization in diabetic women: Analysis from the epistent trial Journal of Womens Health & Gender-Based Medicine  2000 9:741-746  DOI:10.1089/15246090050147718  PMID:11025866
  • Lincoff, A. M., Califf, R. M., Topol, E. J. Platelet glycoprotein IIb/IIIa receptor blockade in coronary artery disease Journal of the American College of Cardiology  2000 35:1103-1115  DOI:10.1016/s0735-1097(00)00554-4  PMID:10758948
  • Hasdai, D., Harrington, R. A., Hochman, J. S., Califf, R. M., Battler, A., Box, J. W., Simoons, M. L., Deckers, J., Topol, E. J., Holmes, D. R. Platelet glycoprotein iib/iiia blockade and outcome of cardiogenic shock complicating acute coronary syndromes without persistent st-segment elevation Journal of the American College of Cardiology  2000 36:685-692  DOI:10.1016/s0735-1097(00)00814-7  PMID:10987585
  • Califf, R. M., Pieper, K. S., Lee, K. L., Van de Werf, F., Simes, R. J., Armstrong, P. W., Topol, E. J., Investigators, Gusto- I. Prediction of 1-year survival after thrombolysis for acute myocardial infarction in the global utilization of streptokinase and tpa for occluded coronary arteries trial Circulation  2000 101:2231-2238  PMID:10811588
  • Hasdai, D., Califf, R. M., Thompson, T. D., Hochman, J. S., Ohman, E. M., Pfisterer, M., Bates, E. R., Vahanian, A., Armstrong, P. W., Criger, D. A., Topol, E. J., Holmes, D. R. Predictors of cardiogenic shock after thrombolytic therapy for acute myocardial infarction Journal of the American College of Cardiology  2000 35:136-143  DOI:10.1016/s0735-1097(99)00508-2  PMID:10636271
  • Brener, S. J., Ellis, S. G., Sapp, S. K., Betriu, A., Granger, C. B., Burchenal, J. E. B., Moliterno, D. J., Califf, R. M., Topol, E. J., Investigators, Gusto IIb RAPPORT Predictors of death and reinfarction at 30 days after primary angioplasty: The gusto iib and rapport trials American Heart Journal  2000 139:476-481  DOI:10.1016/s0002-8703(00)90091-7  PMID:10689262
  • Boersma, E., Pieper, K. S., Steyerberg, E. W., Wilcox, R. G., Chang, W. C., Lee, K. L., Akkerhuis, K. M., Harrington, R. A., Deckers, J. W., Armstrong, P. W., Lincoff, A. M., Califf, R. M., et al. Predictors of outcome in patients with acute coronary syndromes without persistent ST-segment elevation results from an international trial of 9461 patients Circulation  2000 101:2557-2567  PMID:10840005
  • Cura, F. A., Bhatt, D. L., Lincoff, A. M., Kapadia, S. R., L'Allier, P. L., Ziada, K. M., Wolski, K. E., Moliterno, D. J., Brener, S. J., Ellis, S. G., Topol, E. J. Pronounced benefit of coronary stenting and adjunctive platelet glycoprotein IIb/IIIa inhibition in complex atherosclerotic lesions Circulation  2000 102:28-34  PMID:10880411
  • Marso, S. P., Ellis, S. G., Gurm, H. S., Lytle, B. W., Topol, E. J. Proteinuria is a key determinant of death in patients with diabetes after isolated coronary artery bypass grafting American Heart Journal  2000 139:939-944  DOI:10.1067/mhj.2000.105699  PMID:10827372
  • Topol, E. J., Yadav, J. S. Recognition of the importance of embolization in atherosclerotic vascular disease Circulation  2000 101:570-580  PMID:10662756
  • Braunwald, E., Califf, R. M., Cannon, C. P., Fox, K. A. A., Fuster, V., Gibler, W. B., Harrington, R. A., King, S. B., Kleiman, N. S., Theroux, P., Topol, E. J., Van de Werf, F., et al. Redefining medical treatment in the management of unstable angina American Journal of Medicine  2000 108:41-53  DOI:10.1016/s0002-9343(99)00416-7  PMID:11059440
  • Bhatt, D. L., Hirsch, A. T., Ringleb, P. A., Hacke, W., Topol, E. J., Investigators, Caprie Reduction in the need for hospitalization for recurrent ischemic events and bleeding with clopidogrel instead of aspirin American Heart Journal  2000 140:67-73  DOI:10.1067/mhj.2000.108239  PMID:10874265
  • Christenson, R. H., Vollmer, R. T., Ohman, E. M., Peck, S., Thompson, T. D., Duh, S. H., Ellis, S. G., Newby, L. K., Topol, E. J., Califf, R. M., Grp, Tami Study Relation of temporal creatine kinase-mb release and outcome after thrombolytic therapy for acute myocardial infarction American Journal of Cardiology  2000 85:543-547  DOI:10.1016/s0002-9149(99)00808-5  PMID:11078264
  • Crenshaw, B. S., Granger, C. B., Birnbaum, Y., Pieper, K. S., Morris, D. C., Kleiman, N. S., Vahanian, A., Califf, R. M., Topol, E. J., Strepto, Gusto- I. Global Utilization Risk factors, angiographic patterns, and outcomes in patients with ventricular septal defect complicating acute myocardial infarction Circulation  2000 101:27-32  PMID:10618300
  • Cura, F. A., Kapadia, S. R., L'Allier, P. L., Schneider, J. P., Kreindel, M. S., Silver, M. J., Yadav, J. S., Simpfendorfer, C. C., Raymond, R. R., Tuzcu, E. M., Franco, I., Whitlow, P. L., et al. Safety of femoral closure devices after percutaneous coronary interventions in the era of glycoprotein iib/iiia platelet blockade American Journal of Cardiology  2000 86:780-782  DOI:10.1016/s0002-9149(00)01081-x  PMID:11018201
  • Topol, E. J., Ohman, E. M., Armstrong, P. W., Wilcox, R., Skene, A. M., Aylward, P., Simes, J., Dalby, A., Betriu, A., Bode, C., White, H. D., Hochman, J. S., et al. Survival outcomes 1 year after reperfusion therapy with either alteplase or reteplase for acute myocardial infarction - results from the global utilization of streptokinase and t-pa for occluded coronary arteries (gusto) iii trial Circulation  2000 102:1761-1765  PMID:11023929
  • Chang, W. C., Fu, Y. L., Ohman, E. M., Gupta, M., Morris, A., Roth, S. N., Granger, C. B., Califf, R. M., Topol, E. J., Mark, D. B., Armstrong, P. W., Investigators, N. Am GUSTO-I GUSTO-III Temporal evolution in the management of acute st elevation myocardial infarction: The seven-year gusto experience from canada and the united states Canadian Journal of Cardiology  2000 16:1231-1239  PMID:11064297
  • Bhatt, D. L., Lincoff, M., Califf, R. M., Simoons, M. L., Tcheng, J. E., Brener, S. J., Wolski, K. E., Topol, E. J. The benefit of abciximab in percutaneous coronary revascularization is not device-specific American Journal of Cardiology  2000 85:1060-1064  DOI:10.1016/s0002-9149(00)00696-2  PMID:10781752
  • Topol, E. J. The future of antiplatelet therapy: optimizing management in patients with acute coronary syndrome Clinical Cardiology  2000 23:23-28  PMID:11129683
  • Thel, M. C., Califf, R. M., Tardiff, B. E., Gardner, L. H., Sigmon, K. N., Lincoff, A. M., Topol, E. J., Kitt, M. M., Blankenship, J. C., Tcheng, J. E., Investigators, Impact-Ii Timing of and risk factors for myocardial ischemic events after percutaneous coronary intervention (impact-ii) American Journal of Cardiology  2000 85:427-434  DOI:10.1016/s0002-9149(99)00767-5  PMID:10728945
  • Topol, E. J., Ohman, E. M., Barnathan, E., Califf, R. M., Lee, K. L., Lincoff, A. M., Scherer, J., Scott, R., Sketch, M. H., Weisman, H. F., Cantor, W., Evans, B., et al. Trial of abciximab with and without low-dose reteplase for acute myocardial infarction Circulation  2000 101:2788-2794  PMID:10859283
  • Bhatt, D. L., Kapadia, S. R., Yadav, J. S., Topol, E. J. Update on clinical trials of antiplatelet therapy for cerebrovascular diseases Cerebrovascular Diseases  2000 10:34-40  DOI:10.1159/000047602  PMID:11096181
  • Hasdai, D., Holmes, D. R., Califf, R. M., Thompson, T. D., Hochman, J. S., Pfisterer, M., Topol, E. J., Investigators, Gusto- I. Acute ischemic heart disease - cardiogenic shock complicating acute myocardial infarction: Predictors of death American Heart Journal  1999 138:21-31  DOI:10.1016/s0002-8703(99)70241-3  PMID:10385759
  • Steinhubl, S. R., Kottke-Marchant, K., Moliterno, D. J., Rosenthal, M. L., Godfrey, N. K., Coller, B. S., Topol, E. J., Lincoff, A. M. Attainment and maintenance of platelet inhibition through standard dosing of abciximab in diabetic and nondiabetic patients undergoing percutaneous coronary intervention Circulation  1999 100:1977-1982  PMID:10556224
  • Holmes, D. R., Barger, P. B., Hochman, J. S., Granger, C. B., Thompson, T. D., Califf, R. M., Vahanian, A., Bates, E. R., Topol, E. J. Cardiogenic shock in patients with acute ischemic syndromes with and without st-segment elevation Circulation  1999 100:2067-2073  PMID:10562262
  • Tardiff, B. E., Califf, R. M., Tcheng, J. E., Lincoff, A. M., Sigmon, K. N., Harrington, R. A., Mahaffey, K. W., Ohman, E. M., Teirstein, P. S., Blankenship, J. C., Kitt, M. M., Topol, E. J., et al. Clinical outcomes after detection of elevated cardiac enzymes in patients undergoing percutaneous intervention Journal of the American College of Cardiology  1999 33:88-96  DOI:10.1016/s0735-1097(98)00551-8  PMID:9935014
  • Kong, D. F., Topol, E. J., Bittl, J. A., White, H. D., Theroux, P., Hasselblad, V., Califf, R. M. Clinical outcomes of bivalirudin for ischemic heart disease Circulation  1999 100:2049-2053  PMID:10562259
  • Thel, M. C., Califf, R. M., Tcheng, J. E., Sigmon, K. N., Lincoff, A. M., Topol, E. J., Ellis, S. G., Investigators, Epic Clinical risk factors for ischemic complications after percutaneous coronary interventions: Results from the epic trial American Heart Journal  1999 137:264-273  DOI:10.1053/hj.1999.v137.92521  PMID:9924160
  • McClure, M. W., Berkowitz, S. D., Sparapani, R., Tuttle, R., Kleiman, N. S., Berdan, L. G., Lincoff, A. M., Deckers, J., Diaz, R., Karsch, K. R., Gretler, D., Kitt, M., et al. Clinical significance of thrombocytopenia during a non-st-elevation acute coronary syndrome - the platelet glycoprotein iib iiia in unstable angina: Receptor suppression using integrilin therapy (pursuit) trial experience Circulation  1999 99:2892-2900  PMID:10359733
  • Steinhubl, S. R., Topol, E. J. Clopidogrel with aspirin is the optimal antiplatelet regimen for intracoronary stenting Journal of Thrombosis and Thrombolysis  1999 7:227-231  DOI:10.1023/a:1008981408216  PMID:10373712
  • Ellis, S. G., Miller, D., Keys, T. F., Brown, K., Ellert, R., Howell, G., Lincoff, A. M., Topol, E. J. Comparing physician-specific two-year patient outcomes after coronary angiography - methodologic issues and results Journal of the American College of Cardiology  1999 33:1278-1285  DOI:10.1016/s0735-1097(99)00022-4  PMID:10193728
  • Eisenberg, M. J., Taylor, J. M., Cove, C. J., Brown, K. J., Ellis, S. G., Topol, E. J. Comparison of percutaneous coronary revascularization costs among hmo and non-hmo cardiologists practicing in the same institution Journal of Cardiovascular Diagnosis and Procedures  1999 16:87-97
  • Lincoff, A. M., Califf, R. M., Moliterno, D. J., Ellis, S. G., Ducas, J., Kramer, J. H., Kleiman, N. S., Cohen, E. A., Booth, J. E., Sapp, S. K., Cabot, C. F., Topol, E. J., et al. Complementary clinical benefits of coronary-artery stenting and blockade of platelet glycoprotein IIb/IIIa receptors. Evaluation of Platelet IIb/IIIa Inhibition in Stenting Investigators New England Journal of Medicine  1999 341:319-327  DOI:10.1056/nejm199907293410503  PMID:10423466
  • Kleiman, N. S., Granger, C. B., White, H. D., Armstrong, P., Ardissino, D., Van de Werf, F., Zoldeyhi, P., Thompson, T. D., Califf, R. M., Topol, E. J., Investigators, G. USTO-IIb Death and nonfatal reinfarction within the first 24 hours after presentation with an acute coronary syndrome: Experience from gusto-iib American Heart Journal  1999 137:12-23  DOI:10.1016/s0002-8703(99)70455-2  PMID:9878932
  • Brener, S. J., Barr, L. A., Burchenal, J. E. B., Wolski, K. E., Effron, M. B., Topol, E. J., Investigators, Rapport Effect of abciximab on the pattern of reperfusion in patients with acute myocardial infarction treated with primary angioplasty American Journal of Cardiology  1999 84:728-730  DOI:10.1016/s0002-9149(99)00421-x  PMID:10498145
  • Holmes, D. R., White, H. D., Pieper, K. S., Ellis, S. G., Califf, R. M., Topol, E. J. Effect of age on outcome with primary angioplasty versus thrombolysis Journal of the American College of Cardiology  1999 33:412-419  DOI:10.1016/s0735-1097(98)00579-8  PMID:9973021
  • Gilchrist, I. C., Gardner, L. H., Muhlestein, J. B., Arnold, A. M., Lincoff, A. M., Califf, R. M., Tcheng, J. E., Topol, E. J. Effect of institutional volume and academic status on outcomes of coronary interventions: The impact-ii experience American Heart Journal  1999 138:976-982  DOI:10.1016/s0002-8703(99)70026-8  PMID:10539832
  • Miller, J. M., Smalling, R., Ohman, E. M., Bode, C., Betriu, A., Kleiman, N. S., Schildcrout, J. S., Bastos, E., Topol, E. J., Califf, R. M., GUSTO III Investigators Effectiveness of early coronary angioplasty and abciximab for failed thrombolysis (reteplase or alteplase) during acute myocardial infarction (results from the gusto-iii trial) American Journal of Cardiology  1999 84:779-784  DOI:10.1016/s0002-9149(99)00437-3  PMID:10513773
  • Tung, C. Y., Granger, C. B., Sloan, M. A., Topol, E. J., Knight, J. D., Weaver, W. D., Mahaffey, K. W., White, H., Clapp-Channing, N., Simoons, M. L., Gore, J. M., Califf, R. M., et al. Effects of stroke on medical resource use and costs in acute myocardial infarction Circulation  1999 99:370-376  PMID:9918523
  • Hasdai, D., Holmes, D. R., Topol, E. J., Berger, P. B., Criger, D. A., Hochman, J. S., Bates, E. R., Vahanian, A., Armstrong, P. W., Wilcox, R., Ohman, E. M., Califf, R. M. Frequency and clinical outcome of cardiogenic shock during acute myocardial infarction among patients receiving reteplase or alteplase - results from gusto-iii European Heart Journal  1999 20:128-135  DOI:10.1053/euhj.1999.1282  PMID:10099909
  • Steinhubl, S. R., Tan, W. A., Foody, J. M., Topol, E. J., Investigators, Epistent Incidence and clinical course of thrombotic thrombocytopenic purpura due to ticlopidine following coronary stenting JAMA-Journal of the American Medical Association  1999 281:806-810  DOI:10.1001/jama.281.9.806  PMID:10071001
  • Asher, C. R., Topol, E. J., Moliterno, D. J. Insights into the pathophysiology of atherosclerosis and prognosis of black americans with acute coronary syndromes American Heart Journal  1999 138:1073-1081  DOI:10.1016/s0002-8703(99)70072-4  PMID:10577437
  • Harrington, R. A., Califf, R. M., Holmes, D. R., Pieper, K. S., Lincoff, A. M., Berdan, L. G., Thompson, T. D., Topol, E. J., Investigators, Caveat- I. Is all unstable angina the same? Insights from the coronary angioplasty versus excisional atherectamy trial (caveat-i) American Heart Journal  1999 137:227-233  DOI:10.1053/hj.1999.v137.90600  PMID:9924155
  • Simoons, M. L., van den Brand, M., Lincoff, N., Harrington, R., van der Wieken, R., Vahanian, A., Rutsch, W., Kootstra, J., Boersma, E., Califf, R. M., Topol, E. Minimal myocardial damage during coronary intervention is associated with impaired outcome European Heart Journal  1999 20:1112-1119  DOI:10.1053/euhj.1999.1521  PMID:10413641
  • Mahaffey, K. W., Granger, C. B., Sloan, M. A., Green, C. L., Gore, J. M., Weaver, W. D., White, H. D., Simoons, M. L., Barbash, G. I., Topol, E. J., Califf, R. M., Investigators, Gusto I. Neurosurgical evacuation of intracranial hemorrhage after thrombolytic therapy for acute myocardial infarction: Experience from the gusto-i trial American Heart Journal  1999 138:493-499  DOI:10.1016/s0002-8703(99)70152-3  PMID:10467200
  • Topol, E. J. New platelet glycoprotein IIb/IIIa inhibitor trials in percutaneous coronary intervention Journal of Invasive Cardiology  1999 11:3C-6C  PMID:10745614
  • Berger, P. B., Tuttle, R. H., Holmes, D. R., Topol, E. J., Aylward, P. E., Horgan, J. H., Califf, R. M., Investigators, Gusto I. One-year survival among patients with acute myocardial infarction complicated by cardiogenic shock, and its relation to early revascularization - results from the gusto-i trial Circulation  1999 99:873-878  PMID:10027808
  • Marso, S. P., Lincoff, A. M., Ellis, S. G., Bhatt, D. L., Tanguay, J. F., Kleiman, N. S., Hammoud, T., Booth, J. E., Sapp, S. K., Topol, E. J., Investigators, Epistent Optimizing the percutaneous interventional outcomes for patients with diabetes mellitus - results of the epistent (evaluation of platelet iib/iiia inhibitor for stenting trial) diabetic substudy Circulation  1999 100:2477-2484  PMID:10604884
  • Cohen, M. G., Granger, C. B., Ohman, E. M., Stebbins, A. L., Grinfeld, L. R., Cagide, A. M., Elizari, M. V., Betriu, A., Kong, D. F., Topol, E. J., Califf, R. M. Outcome of hispanic patients treated with thrombolytic therapy for acute myocardial infarction - results from the gusto-i and -iii trials Journal of the American College of Cardiology  1999 34:1729-1737  DOI:10.1016/s0735-1097(99)00433-7  PMID:10577563
  • Topol, E. J., Mark, D. B., Lincoff, A. M., Cohen, E., Burton, J., Kleiman, N., Talley, D., Sapp, S., Booth, J., Cabot, C. F., Anderson, K. M., Califf, R. M., et al. Outcomes at 1 year and economic implications of platelet glycoprotein iib/iiia blockade in patients undergoing coronary stenting: Results from a multicentre randomised trial Lancet  1999 354:2019-2024  DOI:10.1016/s0140-6736(99)10018-7  PMID:10636365
  • Boersma, E., Akkerhuis, K. M., Theroux, P., Califf, R. M., Topol, E. J., Simoons, M. L. Platelet glycoprotein iib/iiia receptor inhibition in non-st-elevation acute coronary syndromes - early benefit during medical treatment only, with additional protection during percutaneous coronary intervention Circulation  1999 100:2045-2048  PMID:10562258
  • Topol, E. J., Byzova, T. V., Plow, E. F. Platelet gpiib-iiia blockers Lancet  1999 353:227-231  DOI:10.1016/s0140-6736(98)11086-3  PMID:9923894
  • Alexander, J. H., Harrington, R. A., Tuttle, R. H., Berdan, L. G., Lincoff, A. M., Deckers, J. W., Simoons, M. L., Guerci, A., Hochman, J. S., Wilcox, R. G., Kitt, M. M., Eisenberg, P. R., et al. Prior aspirin use predicts worse outcomes in patients with non-st-elevation acute coronary syndromes American Journal of Cardiology  1999 83:1147-1151  DOI:10.1016/s0002-9149(99)00049-1  PMID:10215274
  • Savonitto, S., Ardissino, D., Granger, C. B., Morando, G., Prando, M. D., Mafrici, A., Cavallini, C., Melandri, G., Thompson, T. D., Vahanian, A., Ohman, E. M., Califf, R. M., et al. Prognostic value of the admission electrocardiogram in acute coronary syndromes JAMA-Journal of the American Medical Association  1999 281:707-713  DOI:10.1001/jama.281.8.707  PMID:10052440
  • Alexander, J. H., Granger, C. B., Sadowski, Z., Aylward, P. E., White, H. D., Thompson, T. D., Califf, R. M., Topol, E. J., Investigators, Gusto- I. Gusto- IIb Prophylactic lidocaine use in acute myocardial infarction: Incidence and outcomes from two international trials American Heart Journal  1999 137:799-805  DOI:10.1016/s0002-8703(99)70402-3  PMID:10220627
  • Horrigan, M. C. G., Malycky, J. L., Ellis, S. G., Topol, E. J., Nicolini, F. A. Reduction in myocardial infarct size by basic fibroblast growth factor following coronary occlusion in a canine model International Journal of Cardiology  1999 68:S85-S91  DOI:10.1016/s0167-5273(98)00296-4  PMID:10328616
  • Ellis, S. G., Guetta, V., Miller, D., Whitlow, P. L., Topol, E. J. Relation between lesion characteristics and risk with percutaneous intervention in the stent and glycoprotein iib/iiia era - an analysis of results from 10 907 lesions and proposal for new classification scheme Circulation  1999 100:1971-1976  PMID:10556223
  • Berger, P. B., Ellis, S. G., Holmes, D. R., Granger, C. B., Criger, D. A., Betriu, A., Topol, E. J., Califf, R. M., Investigators, Gusto Ii Relationship between delay in performing direct coronary angioplasty and early clinical outcome in patients with acute myocardial infarction - results from the global use of strategies to open occluded arteries in acute coronary syndromes (gusto-iib) trial Circulation  1999 100:14-20  PMID:10393675
  • Gassler, J. P., Topol, E. J. Reperfusion revisited: beyond TIMI 3 flow Clinical Cardiology  1999 22:20-29  PMID:10492850
  • Ohman, E. M., Armstrong, P. W., White, H. D., Granger, C. B., Wilcox, R. G., Weaver, W. D., Gibler, W. B., Stebbins, A. L., Cianciolo, C., Califf, R. M., Topol, E. J., GUSTO III Investigators Risk stratification with a point-of-care cardiac troponin t test in acute myocardial infarction American Journal of Cardiology  1999 84:1281-1286  DOI:10.1016/s0002-9149(99)00558-5  PMID:10614791
  • Hochman, J. S., Tamis, J. E., Thompson, T. D., Weaver, W. D., White, H. D., Van de Werf, F., Aylward, P., Topol, E. J., Califf, R. M., Global Use Strategies Open Occluded Coronary, Ar Sex, clinical presentation, and outcome in patients with acute coronary syndromes New England Journal of Medicine  1999 341:226-232  DOI:10.1056/nejm199907223410402  PMID:10413734
  • Van de Werf, F., Adgey, J., Ardissino, D., Armstrong, P. W., Aylward, P., Barbash, G., Betriu, A., Binbrek, A. S., Califf, R., Diaz, R., Fanebust, R., Fox, K., et al. Single-bolus tenecteplase compared with front-loaded alteplase in acute myocardial infarction: The assent-2 double-blind randomised trial Lancet  1999 354:716-722  DOI:10.1016/s0140-6736(99)07403-6  PMID:10475182
  • Hasdai, D., Lerman, A., Rihal, C. S., Criger, D. A., Garratt, K. N., Betriu, A., White, H. D., Topol, E. J., Granger, C. B., Ellis, S. G., Califf, R. M., Holmes, D. R. Smoking status and outcome after primary coronary angioplasty for acute myocardial infarction American Heart Journal  1999 137:612-620  DOI:10.1016/s0002-8703(99)70213-9  PMID:10097222
  • Rabbani, R., Topol, E. J. Strategies to achieve coronary arterial plaque stabilization Cardiovascular Research  1999 41:402-417  DOI:10.1016/s0008-6363(98)00279-x  PMID:10341840
  • Mahaffey, K. W., Harrington, R. A., Simoons, M. L., Granger, C. B., Graffagnino, C., Alberts, M. J., Laskowitz, D. T., Miller, J. M., Sloan, M. A., Berdan, L. G., MacAulay, C. M., Lincoff, A. M., et al. Stroke in patients with acute coronary syndromes - incidence and outcomes in the platelet glycoprotein iib/iiia in unstable angina: Receptor suppression using integrilin therapy (pursuit) trial Circulation  1999 99:2371-2377  PMID:10318656
  • Puma, J. A., Sketch, M. H., Thompson, T. D., Simes, R. J., Morris, D. C., White, H. D., Topol, E. J., Califf, R. M. Support for the open-artery hypothesis in survivors of acute myocardial infarction: Analysis of 11,228 patients treated with thrombolytic therapy American Journal of Cardiology  1999 83:482-487  DOI:10.1016/s0002-9149(98)00899-6  PMID:10073847
  • Lincoff, A. M., Tcheng, J. E., Califf, R. M., Kereiakes, D. J., Kelly, T. A., Timmis, G. C., Kleiman, N. S., Booth, J. E., Balog, C., Cabot, C. F., Anderson, K. M., Weisman, H. F., et al. Sustained suppression of ischemic complications of coronary intervention by platelet gp iib/iiia blockade with abciximab - one-year outcome in the epilog trial Circulation  1999 99:1951-1958  PMID:10208997
  • Califf, R. M., Stump, D., Topol, E. J., Mark, D. B. The impact of the cost-effectiveness study of gusto-1 on decision making with regard to fibrinolytic therapy American Heart Journal  1999 137:S90-S93  DOI:10.1016/s0002-8703(99)70438-2  PMID:10220606
  • Marso, S. P., Ellis, S. G., Tuzcu, E. M., Whitlow, P. L., Franco, I., Raymond, R. E., Topol, E. J. The importance of proteinuria as a determinant of mortality following percutaneous coronary revascularization in diabetics Journal of the American College of Cardiology  1999 33:1269-1277  DOI:10.1016/s0735-1097(99)00035-2  PMID:10193727
  • Patel, V. B., Topol, E. J. The pathogenesis and spectrum of acute coronary syndromes: From plaque formation to thrombosis Cleveland Clinic Journal of Medicine  1999 66:561-571  PMID:10535182
  • Narins, C. R., Miller, D. P., Califf, R. M., Topol, E. J. The relationship between periprocedural myocardial infarction and subsequent target vessel revascularization following percutaneous coronary revascularization - insights from the epic trial Journal of the American College of Cardiology  1999 33:647-653  DOI:10.1016/s0735-1097(98)00620-2  PMID:10080464
  • Kereiakes, D. J., Lincoff, A. M., Miller, D. P., Tcheng, J. E., Cabot, C. F., Anderson, K. M., Weisman, H. F., Califf, R. M., Topol, E. J., Investigation, Epilog Trial Abciximab therapy and unplanned coronary stent deployment - favorable effects on stent use, clinical outcomes, and bleeding complications Circulation  1998 97:857-864  PMID:9521334
  • Armstrong, P. W., Fu, Y. L., Chang, W. C., Topol, E. J., Granger, C. B., Betriu, A., Van de Werf, F., Lee, K. L., Califf, R. M., Investigators, G. USTO-IIb Acute coronary syndromes in the gusto-iib trial - prognostic insights and impact of recurrent ischemia Circulation  1998 98:1860-1868  PMID:9799205
  • Sgarbossa, E. B., Pinski, S. L., Topol, E. J., Califf, R. M., Barbagelata, A., Goodman, S. G., Gates, K. B., Granger, C. B., Miller, D. P., Underwood, D. A., Wagner, G. S., Investigators, Gusto- I. Acute myocardial infarction and complete bundle branch block at hospital admission: Clinical characteristics and outcome in the thrombolytic Journal of the American College of Cardiology  1998 31:105-110  DOI:10.1016/s0735-1097(97)00446-4  PMID:9426026
  • Motwani, J. G., Topol, E. J. Aortocoronary saphenous vein graft disease - pathogenesis, predisposition, and prevention Circulation  1998 97:916-931  PMID:9521341
  • Pfisterer, M., Cox, J. L., Granger, C. B., Brener, S. J., Naylor, C. D., Califf, R. M., van de Werf, F., Stebbins, A. L., Lee, K. L., Topol, E. J., Armstrong, P. W., Investigators, Gusto- I. Atenolol use and clinical outcomes after thrombolysis for acute myocardial infarction: The gusto-i experience Journal of the American College of Cardiology  1998 32:634-640  DOI:10.1016/s0735-1097(98)00279-4  PMID:9741504
  • Simons, G. R., Sgarbossa, E., Wagner, G., Califf, R. M., Topol, E. J., Natale, A. Atrioventricular and intraventricular conduction disorders in acute myocardial infarction: A reappraisal in the thrombolytic era Pace-Pacing and Clinical Electrophysiology  1998 21:2651-2663  DOI:10.1111/j.1540-8159.1998.tb00042.x  PMID:9894656
  • Brieger, D. B., Mak, K. H., White, H. D., Kleiman, N. S., Miller, D. P., Vahanian, A., Ross, A. M., Califf, R. M., Topol, E. J., Investigators, Gusto- I. Benefit of early sustained reperfusion in patients with prior myocardial infarction (the gusto-i trial) American Journal of Cardiology  1998 81:282-287  DOI:10.1016/s0002-9149(97)00909-0  PMID:9468068
  • Christenson, R. H., Duh, S. H., Newby, L. K., Ohman, E. M., Califf, R. M., Granger, C. B., Peck, S., Pieper, K. S., Armstrong, P. W., Katus, H. A., Topol, E. J., Investigators, G. USTO-IIa Cardiac troponin t and cardiac troponin i: Relative values in short-term risk stratification of patients with acute coronary syndromes Clinical Chemistry  1998 44:494-501  PMID:9510853
  • Kong, D. F., Califf, R. M., Miller, D. P., Moliterno, D. J., White, H. D., Harrington, R. A., Tcheng, J. E., Lincoff, A. M., Hasselblad, V., Topol, E. J. Clinical outcomes of therapeutic agents that block the platelet glycoprotein iib/iiia integrin in ischemic heart disease Circulation  1998 98:2829-2835  PMID:9860783
  • Gebel, J. M., Sila, C. A., Sloan, M. A., Granger, C. B., Weisenberger, J. P., Green, C. L., Topol, E. J., Mahaffey, K. W. Comparison of the abc/2 estimation technique to computer-assisted volumetric analysis of intraparenchymal and subdural hematomas complicating the gusto-1 trial Stroke  1998 29:1799-1801  PMID:9731597
  • Benzaquen, B. S., Eisenberg, M. J., Challapalli, R., Nguyen, T., Brown, K. J., Topol, E. J. Correlates of in-hospital cost among patients undergoing abdominal aortic aneurysm repair American Heart Journal  1998 136:696-702  DOI:10.1016/s0002-8703(98)70018-3  PMID:9778074
  • Ellis, S. G., Brown, K. J., Ellert, R., Howell, G. L., Miller, D. P., Flowers, N. M., Ott, P. A., Keys, T., Loop, F. D., Topol, E. J. Cost of cardiac care in the three years after coronary catheterization in a contained care system: Critical determinants and implications Journal of the American College of Cardiology  1998 31:1306-1313  DOI:10.1016/s0735-1097(98)00081-3  PMID:9581725
  • Topol, E. J. Current and emerging anti-thrombotic therapies for acute coronary syndromes Journal of Invasive Cardiology  1998 10:2D-7D  PMID:10762992
  • Serebruany, V. L., Gurbel, P. A., Shustov, A. R., Dalesandro, M. R., Gumbs, C. I., Grabletz, L. B., Bahr, R. D., Ohman, E. M., Topol, E. J., GUSTO III Investigators Depressed platelet status in an elderly patient with hemorrhagic stroke after thrombolysis for acute myocardial infarction Stroke  1998 29:235-238  PMID:9445356
  • Kleiman, N. S., Lincoff, A. M., Kereiakes, D. J., Miller, D. P., Aguirre, F. V., Anderson, K. M., Weisman, H. F., Califf, R. M., Topol, E. J., Investigators, Epilog Diabetes mellitus, glycoprotein iib/iiia blockade, and heparin - evidence for a complex interaction in a multicenter trial Circulation  1998 97:1912-1920  PMID:9609084
  • Khan, M. M., Ellis, S. G., Aguirre, F. V., Weisman, H. F., Wildermann, N. M., Califf, R. M., Topol, E. J., Kleiman, N. S., Invest, Epic Does intracoronary thrombus influence the outcome of high risk percutaneous transluminal coronary angioplasty? Clinical and angiographic outcomes in a large multicenter trial Journal of the American College of Cardiology  1998 31:31-36  DOI:10.1016/s0735-1097(97)00423-3  PMID:9426014
  • Topol, E. J. Drafter and draftees Lancet  1998 352:897-898  DOI:10.1016/s0140-6736(05)60036-0  PMID:9743001
  • Topol, E. EPISTENT (Evaluation of platelet IIb/IIIa inhibitor for stenting trial) Clinical Cardiology  1998 21:513-514
  • Gurbel, P. A., Serebruany, V. L., Shustov, A. R., Bahr, R. D., Carpo, C., Ohman, E. A., Topol, E. J., GUSTO III Investigators Effects of reteplase and alteplase on platelet aggregation and major receptor expression during the first 24 hours of acute myocardial infarction treatment Journal of the American College of Cardiology  1998 31:1466-1473  DOI:10.1016/s0735-1097(98)00172-7  PMID:9626821
  • Topol, E. J. Evolution of improved antithrombotic and antiplatelet agents: Genesis of the comparison of abciximab complications with hirulog and back-up abciximab events trial (cachet) American Journal of Cardiology  1998 82:63P-68P  DOI:10.1016/s0002-9149(98)00664-x  PMID:9809894
  • Ross, A. M., Coyne, K. S., Moreyra, E., Reiner, J. S., Greenhouse, S. W., Walker, P. L., Simoons, M. L., Draoui, Y. C., Califf, R. M., Topol, E. J., Van de Werf, F., Lundergan, C. F., et al. Extended mortality benefit of early postinfarction reperfusion Circulation  1998 97:1549-1556  PMID:9593559
  • Topol, E. J., Serruys, P. W. Frontiers in interventional cardiology Circulation  1998 98:1802-1820  PMID:9788837
  • Brieger, D. B., Mak, K. H., Kottke-Marchant, K., Topol, E. J. Heparin-induced thrombocytopenia Journal of the American College of Cardiology  1998 31:1449-1459  DOI:10.1016/s0735-1097(98)00134-x  PMID:9626819
  • Serebruany, V. L., Gurbel, P. A., Shustov, A. R., Ohman, E. M., Topol, E. J. Heterogeneity of platelet aggregation and major surface receptor expression in patients with acute myocardial infarction American Heart Journal  1998 136:398-405  DOI:10.1016/s0002-8703(98)70212-1  PMID:9736129
  • Hochrein, J., Sun, F. C., Pieper, K. S., Lee, K. L., Gates, K. B., Armstrong, P. W., Weaver, W. D., Goodman, S. G., Topol, E. J., Califf, R. M., Granger, C. B., Wagner, G. S. Higher t-wave amplitude associated with better prognosis in patients receiving thrombolytic therapy for acute myocardial infarction (a gusto-i substudy) American Journal of Cardiology  1998 81:1078-1084  DOI:10.1016/s0002-9149(98)00112-x  PMID:9605045
  • Mak, K. H., Kottke-Marchant, K., Brooks, L. M., Topol, E. J. In vitro efficacy of platelet glycoprotein IIb/IIIa antagonist in blocking platelet function in plasma of patients with heparin-induced thrombocytopenia Thrombosis and Haemostasis  1998 80:989-993  PMID:9869172
  • Gurbel, P. A., Serebruany, V. L., Shustov, A. R., Dalesandro, M., Gumbs, C. I., Grablutz, L. B., Bahr, R. D., Ohman, E. M., Topol, E. J. Increased baseline levels of platelet p-selectin, and platelet-endothelial cell adhesion molecule-1 in patients with acute myocardial infarction as predictors of unsuccessful thrombolysis Coronary Artery Disease  1998 9:451-456  DOI:10.1097/00019501-199809070-00008  PMID:9822864
  • Omoigui, N. A., Silver, M. J., Rybicki, L. A., Rosenthal, M., Berdan, L. G., Pieper, K., King, S. V., Califf, R. M., Topol, E. J. Influence of a randomized clinical trial on practice by participating investigators: Lessons from the coronary angioplasty versus excisional atherectomy trial (caveat) Journal of the American College of Cardiology  1998 31:265-272  DOI:10.1016/s0735-1097(97)00498-1  PMID:9462565
  • Topol, E., Califf, R., Simoons, M., Diaz, R., Paolasso, E., Klein, W., Boland, J., DeBacker, G., Armstrong, P., Corbalan, R., Isaza, D., Widimsky, P., et al. Inhibition of platelet glycoprotein IIb/IIIa with eptifibatide in patients with acute coronary syndromes New England Journal of Medicine  1998 339:436-443  PMID:9705684
  • Topol, E., Molitemo, D. J., Investigators, PARAGON International, randomized, controlled trial of lamifiban (a platelet glycoprotein iib/iiia inhibitor), heparin, or both in unstable angina Circulation  1998 97:2386-2395  DOI:10.1161/01.CIR.97.24.2386  PMID:9641689
  • Mandak, J. S., Blankenship, J. C., Gardner, L. H., Berkowitz, S. D., Aguirre, F. V., Sigmon, K. N., Timmis, G. C., Gilchrist, I. C., McIvor, M., Resar, J., Weiner, B. H., George, B. S., et al. Modifiable risk factors for vascular access site complications in the impact ii trial of angioplasty with versus without eptifibatide Journal of the American College of Cardiology  1998 31:1518-1524  DOI:10.1016/s0735-1097(98)00130-2  PMID:9626829
  • Califf, R. M., Abdelmeguid, A. E., Kuntz, R. E., Popma, J. J., Davidson, C. J., Cohen, E. A., Kleiman, N. S., Mahaffey, K. W., Topol, E. J., Pepine, C. J., Lipicky, R. J., Granger, C. B., et al. Myonecrosis after revascularization procedures Journal of the American College of Cardiology  1998 31:241-251  DOI:10.1016/s0735-1097(97)00506-8  PMID:9462562
  • Goodman, S. G., Langer, A., Ross, A. M., Wildermann, N. M., Barbagelata, A., Sgarbossa, E. B., Wagner, G. S., Granger, C. B., Califf, R. M., Topol, E. J., Simoons, M. L., Armstrong, P. W., et al. Non-q-wave versus q-wave myocardial infarction after thrombolytic therapy - angiographic and prognostic insights from the global utilization of streptokinase and tissue plasminogen activator for occluded coronary arteries-i angiographic substudy Circulation  1998 97:444-450  PMID:9490238
  • Berkowitz, S. D., Sane, D. C., Sigmon, K. N., Shavender, J. H., Harrington, R. A., Tcheng, J. E., Topol, E. J., Califf, R. M., Eval c, E. Prev Isch Compl Epic Stud Grp Occurrence and clinical significance of thrombocytopenia in a population undergoing high-risk percutaneous coronary revascularization Journal of the American College of Cardiology  1998 32:311-319  DOI:10.1016/s0735-1097(98)00252-6  PMID:9708455
  • Topol, E. Patient stratification and its predictive value for cardiac events European Heart Journal  1998 19:K5-K7  PMID:9790282
  • Kereiakes, D. J., Kleiman, N. S., Ferguson, J. J., Masud, Z., Broderick, T. M., Abbottsmith, C. W., Runyon, J. P., Anderson, L. C., Anders, R. J., Dreiling, R. J., Hantsbarger, G. L., Bryzinski, B., et al. Pharmacodynamic efficacy, clinical safety, and outcomes after prolonged platelet glycoprotein iib/iiia receptor blockade with oral xemilofiban - results of a multicenter, placebo-controlled, randomized trial Circulation  1998 98:1268-1278  PMID:9751674
  • Ghaffari, S., Kereiakes, D. J., Lincoff, A. M., Kelly, T. A., Timmis, G. C., Kleiman, N. S., Ferguson, J. J., Miller, D. P., Califf, R. A., Topol, E. J., Investigators, Epilog Platelet glycoprotein iib/iia receptor blockade with abciximab reduces ischemic complications in patients undergoing directional coronary atherectomy American Journal of Cardiology  1998 82:7-12  DOI:10.1016/s0002-9149(98)00238-0  PMID:9671000
  • Alexander, K. P., Peterson, E. D., Granger, C. B., Casas, A. C., Van de Werf, F., Armstrong, P. W., Guerci, A., Topol, E. J., Califf, R. M., Investigators, G. USTO-IIb Potential impact of evidence-based medicine in acute coronary syndromes: Insights from gusto-iib Journal of the American College of Cardiology  1998 32:2023-2030  DOI:10.1016/s0735-1097(98)00466-5  PMID:9857888
  • Sloan, M. A., Sila, C. A., Mahaffey, K. W., Granger, C. B., Longstreth, W. T., Koudstaal, P., White, H. D., Gore, J. M., Simoons, M. L., Weaver, W. D., Green, C. L., Topol, E. J., et al. Prediction of 30-day mortality among patients with thrombolysis-related intracranial hemorrhage Circulation  1998 98:1376-1382  PMID:9760291
  • Anderson, R. D., Ohman, E. M., Holmes, D. R., Harrington, R. A., Barsness, G. W., Wildermann, N. M., Phillips, H. R., Topol, E. J., Califf, R. M. Prognostic value of congestive heart failure history in patients undergoing percutaneous coronary interventions Journal of the American College of Cardiology  1998 32:936-941  DOI:10.1016/s0735-1097(98)00339-8  PMID:9768714
  • Gibler, W. B., Wilcox, R. G., Bode, C., Castaigne, A. D., Delooz, H., Elich, D., Fox, K. A. A., Kereiakes, D. J., Rupprecht, H., Topol, E. J. Prospective use of glycoprotein iib/iiia receptor blockers in the emergency department setting Annals of Emergency Medicine  1998 32:712-722  DOI:10.1016/s0196-0644(98)70072-1  PMID:9832669
  • Topol, E. J., Lincoff, A. M., Califf, R. M., Tcheng, J. E., Kleiman, N. S., Adelman, A. G., Burton, J. R., Talley, J. D., Ivanhoe, R. J., Ducas, C., Cheung, P. K., Schick, U., et al. Randomised placebo-controlled and balloon-angioplasty-controlled trial to assess safety of coronary stenting with use of platelet glycoprotein-IIb/IIIa blockade Lancet  1998 352:87-92  DOI:10.1016/s0140-6736(98)85010-1  PMID:9672272
  • Metz, B. K., White, H. D., Granger, C. B., Simes, R. J., Armstrong, P. W., Hirsh, J., Fuster, V., MacAulay, C. M., Califf, R. M., Topol, E. J., Global Use Strategies Open Occluded Coronary, A. Randomized comparison of direct thrombin inhibition versus heparin in conjunction with fibrinolytic therapy for acute myocardial infarction: Results from the gusto-iib trial Journal of the American College of Cardiology  1998 31:1493-1498  DOI:10.1016/s0735-1097(98)00138-7  PMID:9626825
  • Brener, S. J., Barr, L. A., Burchenal, J. E. B., Katz, S., George, B. S., Jones, A. A., Cohen, E. D., Gainey, P. C., White, H. J., Cheek, H. B., Moses, J. W., Moliterno, D. J., et al. Randomized, placebo-controlled trial of platelet glycoprotein iib/iiia blockade with primary angioplasty for acute myocardial infarction Circulation  1998 98:734-741  PMID:9727542
  • Betriu, A., Califf, R. M., Bosch, X., Guerci, A., Stebbins, A. L., Barbagelata, A., Aylward, P. E., Vahanian, A., Van de Werf, F., Topol, E. J., Investigators, Gusto- I. Recurrent ischemia after thrombolysis: Importance of associated clinical findings Journal of the American College of Cardiology  1998 31:94-102  DOI:10.1016/s0735-1097(97)00428-2  PMID:9426024
  • Ellis, S. G., Lincoff, A. M., Miller, D., Tcheng, J. E., Kleiman, N. S., Kereiakes, D., Califf, R., Topol, E. J., Investigators, Epilog, Investigators, Epic Reduction in complications of angioplasty with abciximab occurs largely independently of baseline lesion morphology Journal of the American College of Cardiology  1998 32:1619-1623  DOI:10.1016/s0735-1097(98)00403-3  PMID:9822087
  • Bhatt, D. L., Lincoff, A. M., Kereiakes, D. J., Tcheng, J. E., Simoons, M. L., van der Wieken, L. R., Godfrey, N., Califf, R. M., Topol, E. J. Reduction in the need for unplanned stenting with the use of platelet glycoprotein iib/iiia blockade in percutaneous coronary intervention American Journal of Cardiology  1998 82:1105-1106  DOI:10.1016/s0002-9149(98)00565-7  PMID:9817488
  • Mahaffey, K. W., Granger, C. B., Sloan, M. A., Thompson, T. D., Gore, J. M., Weaver, W. D., White, H. D., Simoons, M. L., Barbash, G. I., Topol, E. J., Califf, R. M., Investigators, Gusto I. Risk factors for in-hospital nonhemorrhagic stroke in patients with acute myocardial infarction treated with thrombolysis Circulation  1998 97:757-764  PMID:9498539
  • Newby, K. H., Thompson, T., Stebbins, A., Topol, E. J., Califf, R. M., Natale, A., Investigators, Gusto Sustained ventricular arrhythmias in patients receiving thrombolytic therapy: incidence and outcomes Circulation  1998 98:2567-2573  PMID:9843464
  • Mak, K. H., Tan, A. T. H., Chan, C., Koh, T. H., Topol, E. J. The clinical impact of platelet glycoprotein IIb/IIIa receptor blockade in cardiovascular medicine Japanese Circulation Journal-English Edition  1998 62:233-243  DOI:10.1253/jcj.62.233  PMID:9583455
  • Steinhubl, S. R., Lauer, M. S., Mukherjee, D. P., Moliterno, D. J., Lincoff, A. M., Ellis, S. G., Topol, E. J. The duration of pretreatment with ticlopidine prior to stenting is associated with the risk of procedure-related non-q-wave myocardial infarctions Journal of the American College of Cardiology  1998 32:1366-1370  DOI:10.1016/s0735-1097(98)00376-3  PMID:9809949
  • Topol, E. J. The future of antithrombotic and antiplatelet therapy for ischemic heart disease American Heart Journal  1998 136:S66-S68  DOI:10.1053/hj.1998.v136.93431  PMID:9778089
  • Granger, C. B., Becker, R., Tracy, R. P., Califf, R. M., Topol, E. J., Pieper, K. S., Ross, A. M., Roth, S., Lambrew, C., Bovill, E. G., Grp, Gusto- I. Hemostasis Substudy Thrombin generation, inhibition and clinical outcomes in patients with acute myocardial infarction treated with thrombolytic therapy and heparin: Results from the gusto-i trial Journal of the American College of Cardiology  1998 31:497-505  DOI:10.1016/s0735-1097(97)00539-1  PMID:9502626
  • Gebel, J. M., Sila, C. A., Sloan, M. A., Granger, C. B., Mahaffey, K. W., Weisenberger, J., Green, C. L., White, H. D., Gore, J. M., Weaver, W. D., Califf, R. M., Topol, E. J., et al. Thrombolysis-related intracranial hemorrhage - a radiographic analysis of 244 cases from the gusto-1 trial with clinical correlation Stroke  1998 29:563-569  PMID:9506593
  • Zabel, K. M., Granger, C. B., Becker, R. C., Bovill, E. G., Hirsh, J., Aylward, P. E., Topol, E. J., Califf, R. M., Investigators, Gusto- I. Use of bedside activated partial thromboplastin time monitor to adjust heparin dosing after thrombolysis for acute myocardial infarction: Results of gusto-i American Heart Journal  1998 136:868-876  DOI:10.1016/s0002-8703(98)70133-4  PMID:9812083
  • Newby, L. K., Christenson, R. H., Ohman, E. M., Armstrong, P. W., Thompson, T. D., Lee, K. L., Hamm, C. W., Katus, H. A., Cianciolo, C., Granger, C. B., Topol, E. J., Califf, R. M., et al. Value of serial troponin t measures for early and late risk stratification in patients with acute coronary syndromes Circulation  1998 98:1853-1859  PMID:9799204
  • Blankenship, J. C., Hellkamp, A. S., Aguirre, F. V., Demko, S. L., Topol, E. J., Califf, R. M., Investigators, Epic Vascular access site complications after percutaneous coronary intervention with abciximab in the evaluation of c7e3 for the prevention of ischemic complications (epic) trial American Journal of Cardiology  1998 81:36-40  DOI:10.1016/s0002-9149(97)00796-0  PMID:9462603
  • Steinhubl, S. R., Topol, E. J. Stenting for acute myocardial infarction Lancet  1997 350:532-533  DOI:10.1016/s0140-6736(05)63135-2
  • Forrester, J. S., Topol, E. J., Abele, J. E., Holmes, D. R., Skorton, D. J. 28th Bethesda Conference. Task force 5: Assessment, approval, and regulation of new technology Journal of the American College of Cardiology  1997 29:1171-1179  PMID:9137210
  • Betriu, A., Phillips, H., Ellis, S., Topol, E., Califf, R., VanderWerf, F., Ardissino, D., Armstrong, P. W., Aylward, P., Bates, E., Beatt, K., Cheseboro, J., et al. A clinical trial comparing primary coronary angioplasty with tissue plasminogen activator for acute myocardial infarction New England Journal of Medicine  1997 336:1621-1628  PMID:9173270
  • Topol, E., Califf, R., Ohman, E., Wilcox, R., Grinfeld, L., Aylward, P., Simes, R., Probst, P., vandeWerf, F., Armstrong, P., Heikkila, J., Vahanian, A., et al. A comparison of reteplase with alteplase for acute myocardial infarction New England Journal of Medicine  1997 337:1118-1123  PMID:9340503
  • Brener, S. J., Loop, F. D., Lytle, B. W., Ellis, S. G., Cosgrove, D. M., Topol, E. J. A profile of candidates for repeat myocardial revascularization: Implications for selection of treatment Journal of Thoracic and Cardiovascular Surgery  1997 114:153-161  DOI:10.1016/s0022-5223(97)70139-9  PMID:9270630
  • Christenson, R. H., Ohman, E. M., Topol, E. J., Peck, S., Newby, L. K., Duh, S. H., Kereiakes, D. J., Worley, S. J., Alosozana, G. L., Wall, T. C., Califf, R. M. Assessment of coronary reperfusion after thrombolysis with a model combining myoglobin, creatine kinase-mb, and clinical variables Circulation  1997 96:1776-1782  PMID:9323061
  • Crenshaw, B. S., Ward, S. R., Granger, C. B., Stebbins, A. L., Topol, E. J., Califf, R. M. Atrial fibrillation in the setting of acute myocardial infarction: The gusto-i experience Journal of the American College of Cardiology  1997 30:406-413  DOI:10.1016/s0735-1097(97)00194-0  PMID:9247512
  • Narins, C. R., Topol, E. J. Cardiology - attention shifts to the white clot Lancet  1997 350:SIII2-SIII2  PMID:9465178
  • Oconnor, C. M., Hathaway, W. R., Bates, E. R., Leimberger, J. D., Sigmon, K. N., Kereiakes, D. J., George, B. S., Samaha, J. K., Abbottsmith, C. W., Candela, R. J., Topol, E. J., Califf, R. M. Clinical characteristics and long-term outcome of patients in whom congestive heart failure develops after thrombolytic therapy for acute myocardial infarction: Development of a predictive model American Heart Journal  1997 133:663-673  DOI:10.1016/s0002-8703(97)70168-6  PMID:9200394
  • Ohman, E. M., Kleiman, N. S., Gacioch, G., Worley, S. J., Navetta, F. I., Talley, J. D., Anderson, H. V., Ellis, S. G., Cohen, M. D., Spriggs, D., Miller, M., Kereiakes, D., et al. Combined accelerated tissue-plasminogen activator and platelet glycoprotein iib/iiia integrin receptor blockade with integrin in acute myocardial infarction - results of a randomized, placebo-controlled, dose-ranging trial Circulation  1997 95:846-854  PMID:9054741
  • Pietila, K., Hermens, W. T., Harmoinen, A., Baardman, T., Pasternack, A., Topol, E. J., Simoons, M. L. Comparison of peak serum c-reactive protein and hydroxybutyrate dehydrogenase levels in patients with acute myocardial infarction treated with alteplase and streptokinase American Journal of Cardiology  1997 80:1075-1077  DOI:10.1016/s0002-9149(97)00606-1  PMID:9352981
  • Brener, S. J., Ellis, S. G., AppersonHansen, C., Leon, M. B., Topol, E. J. Comparison of stenting and balloon angioplasty for narrowings in aortocoronary saphenous vein conduits in place for more than five years American Journal of Cardiology  1997 79:13-18  PMID:9024728
  • Moliterno, D. J., Topol, E. J. Conjunctive use of platelet glycoprotein IIb/IIIa antagonists and thrombolytic therapy for acute myocardial infarction Thrombosis and Haemostasis  1997 78:214-219  PMID:9198156
  • Krucoff, M. W., Green, C. L., Langer, A., Klootwijk, P., Trollinger, K. M., Pope, J. E., Armstrong, P. W., Simoons, M. L., Topol, E. J., Califf, R. M. Continuous 12-lead st-segment recovery predicts outcome in acute myocardial infarction better than "snapshot" angiograms of timi flow Journal of Electrocardiology  1997 30:167-167
  • Hannan, E. L., Racz, M., Ryan, T. J., McCallister, B. D., Johnson, L. W., Arani, D. T., Guerci, A. D., Sosa, J., Topol, E. J. Coronary angioplasty volume-outcome relationships for hospitals and cardiologists JAMA-Journal of the American Medical Association  1997 277:892-898  DOI:10.1001/jama.277.11.892  PMID:9062327
  • Tardiff, B. E., Califf, R. M., Morris, D., Bates, E., Woodlief, L. H., Lee, K. L., Green, C., Rutsch, W., Betriu, A., Aylward, P. E., Topol, E. J. Coronary revascularization surgery after myocardial infarction: Impact of bypass surgery on survival after thrombolysis Journal of the American College of Cardiology  1997 29:240-249  PMID:9014973
  • Mahaffey, K. W., Granger, C. B., Toth, C. A., White, H. D., Stebbins, A. L., Barbash, G. I., Vahanian, A., Topol, E. J., Califf, R. M. Diabetic retinopathy should not be a contraindication to thrombolytic therapy for acute myocardial infarction: Review of ocular hemorrhage incidence and location in the gusto-i trial Journal of the American College of Cardiology  1997 30:1606-1610  DOI:10.1016/s0735-1097(97)00394-x  PMID:9385883
  • Holmes, D. R., Califf, R. M., VandeWerf, F., Berger, P. B., Bates, E. R., Simoons, M. L., White, H. D., Thompson, T. D., Topol, E. J. Difference in countries' use of resources and clinical outcome for patients with cardiogenic shock after myocardial infarction: Results from the gusto trial Lancet  1997 349:75-78  DOI:10.1016/s0140-6736(96)03031-0  PMID:8996417
  • Mak, K. H., Challapalli, R., Eisenberg, M. J., Anderson, K. M., Califf, R. M., Topol, E. J. Effect of platelet glycoprotein IIb/IIIa receptor inhibition on distal embolization during percutaneous revascularization of aortocoronary saphenous vein grafts American Journal of Cardiology  1997 80:985-988  DOI:10.1016/s0002-9149(97)00589-4  PMID:9352964
  • Ward, S. R., Sutton, J. M., Pieper, K. S., Schwaiger, M., Califf, R. M., Topol, E. J. Effects of thrombolytic regimen, early catheterization, and predischarge angiographic variables on six-week left ventricular function American Journal of Cardiology  1997 79:539-544  PMID:9068505
  • Migrino, R. Q., Young, J. B., Ellis, S. G., White, H. D., Lundergan, C. F., Miller, D. P., Granger, C. B., Ross, A. M., Califf, R. M., Topol, E. J. End-systolic volume index at 90 to 180 minutes into reperfusion therapy for acute myocardial infarction is a strong predictor of early and late mortality Circulation  1997 96:116-121  PMID:9236425
  • Lincoff, A. M., Califf, R. M., Anderson, K. M., Weisman, H. F., Aguirre, F. V., Kleiman, N. S., Harrington, R. A., Topol, E. J. Evidence for prevention of death and myocardial infarction with platelet membrane glycoprotein iib/iiia receptor blockade by abciximab (c7e3 fab) among patients with unstable angina undergoing percutaneous coronary revascularization Journal of the American College of Cardiology  1997 30:149-156  PMID:9207636
  • Simpfendorfer, C., KottkeMarchant, K., Lowrie, M., Anders, R. J., Burns, D. M., Miller, D. P., Cove, C. S., DeFranco, A. C., Ellis, S. G., Moliterno, D. J., Raymond, R. E., Sutton, J. M., et al. First chronic platelet glycoprotein iib/iiia integrin blockade - a randomized, placebo-controlled pilot study of xemilofiban in unstable angina with percutaneous coronary interventions Circulation  1997 96:76-81  PMID:9236420
  • Woodfield, S. L., Lundergan, C. F., Reiner, J. S., Thompson, M. A., Rohrbeck, S. C., Deychak, Y., Smith, J. O., Burton, J. R., McCarthy, W. F., Califf, R. M., White, H. D., Weaver, W. D., et al. Gender and acute myocardial infarction: Is there a different response to thrombolysis? Journal of the American College of Cardiology  1997 29:35-42  PMID:8996292
  • Berger, P. B., Holmes, D. R., Stebbins, A. L., Bates, E. R., Califf, R. M., Topol, E. J. Impact of an aggressive invasive catheterization and revascularization strategy on mortality in patients with cardiogenic shock in the global utilization of streptokinase and tissue plasminogen activator for occluded coronary arteries (gusto-i) trial - an observational study Circulation  1997 96:122-127  PMID:9236426
  • Levine, G. N., Jacobs, A. K., Keeler, G. P., Whitlow, P. L., Berdan, L. G., Leya, F., Topol, E. J., Califf, R. M. Impact of diabetes mellitus on percutaneous revascularization (caveat-i) American Journal of Cardiology  1997 79:748-755  PMID:9070553
  • Berkowitz, S. D., Granger, C. B., Peiper, K. S., Lee, K. L., Gore, J. M., Simoons, M., Armstrong, P. W., Topol, E. J., Califf, R. M. Incidence and predictors of bleeding after contemporary thrombolytic therapy for myocardial infarction Circulation  1997 95:2508-2516  PMID:9184581
  • Mak, K. H., Moliterno, D. J., Granger, C. B., Miller, D. P., White, H. D., Wilcox, R. G., Califf, R. M., Topol, E. J. Influence of diabetes mellitus on clinical outcome in the thrombolytic era of acute myocardial infarction Journal of the American College of Cardiology  1997 30:171-179  PMID:9207639
  • GottsaunerWolf, M., Jang, Y. S., Lincoff, A. M., Cohen, J. L., Labhasetwar, V., Poptic, E. J., Forudi, F., Guzman, L. A., DiCorleto, P. E., Levy, R. J., Topol, E. J., Ellis, S. G. Influence of local delivery of the protein tyrosine kinase receptor inhibitor tyrphostin-47 on smooth-muscle cell proliferation in a rat carotid balloon-injury model American Heart Journal  1997 133:329-334  DOI:10.1016/s0002-8703(97)70228-x  PMID:9060802
  • Ellis, S. G., Brener, S. J., DeLuca, S., Tuzcu, E. M., Raymond, R. E., Whitlow, P. L., Topol, E. J. Late myocardial ischemic events after saphenous vein graft intervention - importance of initially ''nonsignificant'' vein graft lesions American Journal of Cardiology  1997 79:1460-1464  PMID:9185633
  • Brieger, D., Topol, E. Local drug delivery systems and prevention of restenosis Cardiovascular Research  1997 35:405-413  DOI:10.1016/s0008-6363(97)00155-7  PMID:9415284
  • Moen, E. K., Asher, C. R., Miller, D. P., Weaver, W. D., White, H. D., Califf, R. M., Topol, E. J. Long-term follow-up of gender-specific outcomes after thrombolytic therapy for acute myocardial infarction from the gusto-i trial Journal of Womens Health  1997 6:285-293  DOI:10.1089/jwh.1997.6.285  PMID:9201663
  • Topol, E. J., Ferguson, J. J., Weisman, H. F., Tcheng, J. E., Ellis, S. G., Kleiman, N. S., Ivanhoe, R. J., Wang, A. L., Miller, D. P., Anderson, K. M., Califf, R. M. Long-term protection from myocardial ischemic events in a randomized trial of brief integrin beta(3) blockade with percutaneous coronary intervention JAMA-Journal of the American Medical Association  1997 278:479-484  DOI:10.1001/jama.278.6.479  PMID:9256222
  • Topol, E. J., Califf, R. M., VandeWerf, F., Simoons, M., Hampton, J., Lee, K. L., White, H., Simes, J., Armstrong, P. W. Perspectives on large-scale cardiovascular clinical trials for the new millennium Circulation  1997 95:1072-1082  PMID:9054772
  • Lefkovits, J., Topol, E. J. Pharmacological approaches for the prevention of restenosis after percutaneous coronary intervention Progress in Cardiovascular Diseases  1997 40:141-158  DOI:10.1016/s0033-0620(97)80006-0  PMID:9327830
  • Topol, E. J., Califf, R. M., Lincoff, A. M., Tcheng, J. E., Cabot, C. F., Weisman, H. F., Kereiakes, D., Lausten, D., Runyon, J. P., Howard, W., Kelly, T., Muncy, D., et al. Platelet glycoprotein IIb/IIIa receptor blockade and low-dose heparin during percutaneous coronary revascularization New England Journal of Medicine  1997 336:1689-1696  PMID:9182212
  • GottsaunerWolf, M., Jang, Y. S., Penn, M. S., Kaplan, A., Ellis, S. G., Chisolm, G. M., Topol, E. J., Lincoff, A. M. Quantitative evaluation of local drug delivery using the infusasleeve catheter Catheterization and Cardiovascular Diagnosis  1997 42:102-108  DOI:10.1002/(sici)1097-0304(199709)42:1<102::aid-ccd27>3.0.co;2-r  PMID:9286553
  • Tcheng, J. E., Lincoff, A. M., Sigmon, K. N., Lee, K. L., Kitt, M. M., Califf, R. M., Topol, E. J., Juran, N., Worley, S., Tuzi, J., Hollywood, L., Kleiman, N. S., et al. Randomised placebo-controlled trial of effect of eptifibatide on complications of percutaneous coronary intervention: IMPACT II Lancet  1997 349:1422-1428  PMID:9164315
  • Topol, E. J. Reperfusion for acute myocardial infarction: 1997 and beyond Cleveland Clinic Journal of Medicine  1997 64:9-12  PMID:9014377
  • Califf, R. M., Woodlief, L. H., Harrell, F. E., Lee, K. L., White, H. D., Guerci, A., Barbash, G. I., Simes, R. J., Weaver, W. D. D., Simoons, M. L., Topol, E. J. Selection of thrombolytic therapy for individual patients: Development of a clinical model American Heart Journal  1997 133:630-639  DOI:10.1016/s0002-8703(97)70164-9  PMID:9200390
  • Lincoff, A. M., Tcheng, J. E., Califf, R. M., Bass, T., Popma, J. J., Teirstein, P. S., Kleiman, N. S., Hattel, L. J., Anderson, H. V., Ferguson, J. J., Cabot, C. F., Anderson, K. M., et al. Standard versus low-dose weight-adjusted heparin in patients treated with the platelet glycoprotein iib/iiia receptor antibody fragment abciximab (c7e3 fab) during percutaneous coronary revascularization American Journal of Cardiology  1997 79:286-291  PMID:9036746
  • Belli, G., Ellis, S. G., Topol, E. J. Stenting for ischemic heart disease Progress in Cardiovascular Diseases  1997 40:159-182  DOI:10.1016/s0033-0620(97)80007-2  PMID:9327831
  • Lincoff, A. M., Furst, J. G., Ellis, S. G., Tuch, R. J., Topol, E. J. Sustained local delivery of dexamethasone by a novel intravascular eluting stent to prevent restenosis in the porcine coronary injury model Journal of the American College of Cardiology  1997 29:808-816  PMID:9091528
  • Barbagelata, N. A., Granger, C. B., Oqueli, E., Suarez, L. D., Borruel, M., Topol, E. J., Califf, R. M. Timi grade 3 flow and reocclusion after intravenous thrombolytic therapy: A pooled analysis American Heart Journal  1997 133:273-282  DOI:10.1016/s0002-8703(97)70220-5  PMID:9060794
  • Eisenberg, M. J., Califf, R. M., Cohen, E. A., Adelman, A. G., Mark, D. B., Topol, E. J. Use of evidence-based medical therapy in patients undergoing percutaneous coronary revascularization in the united states, europe, and canada American Journal of Cardiology  1997 79:867-872  PMID:9104896
  • Anderson, R. D., Ohman, E. M., Holmes, D. R., Col, J., Stebbins, A. L., Bates, E. R., Stomel, R. J., Granger, C. B., Topol, E. J., Califf, R. M. Use of intraaortic balloon counterpulsation in patients presenting with cardiogenic shock: Observations from the gusto-i study Journal of the American College of Cardiology  1997 30:708-715  DOI:10.1016/s0735-1097(97)00227-1  PMID:9283530
  • Brener, S. J., Leya, F. S., AppersonHansen, C., Cowley, M. J., Califf, R. M., Topol, E. J. A comparison of debulking versus dilatation of bifurcation coronary arterial narrowings (from the caveat i trial) American Journal of Cardiology  1996 78:1039-1041  DOI:10.1016/s0002-9149(96)00531-0  PMID:8916485
  • Topol, E. J., Califf, R., Granger, C., VandeWerf, F., Aylward, P., Simes, J., Col, J., Armstrong, P., Vahanian, A., Neuhaus, K., Rutsch, W., Ardissino, D., et al. A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes New England Journal of Medicine  1996 335:775-782  DOI:10.1056/NEJM199609123351103  PMID:8778585
  • Gent, M., Beaumont, D., Blanchard, J., Bousser, M. G., Coffman, J., Easton, J. D., Hampton, J. R., Harker, L. A., Janzon, L., Kusmierek, J. J. E., Panak, E., Roberts, R. S., et al. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (caprie) Lancet  1996 348:1329-1339  PMID:8918275
  • Mak, K. H., Eisenberg, M. J., Plante, S., Strauss, B. H., Arheart, K. L., Topol, E. J. Absence of increased in-hospital complications with reused balloon catheters American Journal of Cardiology  1996 78:717-719  DOI:10.1016/s0002-9149(96)00443-2  PMID:8831419
  • Granger, C. B., Hirsh, J., Califf, R. M., Col, J., White, H. D., Betriu, A., Woodlief, L. H., Lee, K. L., Bovill, E. G., Simes, J., Topol, E. J. Activated partial thromboplastin time and outcome after thrombolytic therapy for acute myocardial infarction: Results for the gusto-i trial Circulation  1996 93:870-878  PMID:8598077
  • White, H. D., Barbash, G. I., Califf, R. M., Simes, R. J., Granger, C. B., Weaver, W. D., Kleiman, N. S., Aylward, P. E., Gore, J. M., Vahanian, A., Lee, K. L., Ross, A. M., et al. Age and outcome with contemporary thrombolytic therapy - results from the gusto-i trial Circulation  1996 94:1826-1833  PMID:8873656
  • Ellis, S. G., Omoigui, N., Bittl, J. A., Lincoff, M., Wolfe, M. W., Howell, G., Topol, E. J. Analysis and comparison of operator-specific outcomes in interventional cardiology - from a multicenter database of 4860 quality-controlled procedures Circulation  1996 93:431-439  PMID:8565159
  • Woodfield, S. L., Lundergan, C. F., Reiner, J. S., Greenhouse, S. W., Thompson, M. A., Rohrbeck, S. C., Deychak, Y., Simoons, M. L., Califf, R. M., Topol, E. J., Ross, A. M. Angiographic findings and outcome in diabetic patients treated with thrombolytic therapy for acute myocardial infarction: The gusto-i experience Journal of the American College of Cardiology  1996 28:1661-1669  PMID:8962549
  • Almony, G. T., Lefkovits, J., Topol, E. J. Antiplatelet and anticoagulant use after myocardial infarction Clinical Cardiology  1996 19:357-365  PMID:8723593
  • Ohman, E. M., Armstrong, P. W., Christenson, R. H., Granger, C. B., Katus, H. A., Hamm, C. W., Ohanesian, M. A., Wagner, G. S., Kleiman, N. S., Harrell, F. E., Califf, R. M., Topol, E. J. Cardiac troponin t levels for risk stratification in acute myocardial ischemia New England Journal of Medicine  1996 335:1333-1341  DOI:10.1056/nejm199610313351801  PMID:8857016
  • Aguirre, F. V., Topol, E. J., Anderson, K. M., Kleiman, N. S., Weisman, H. E., FitzPatrick, S. E., Califf, R. M. Clinical benefit within patient subgroups receiving c7e3 fab (abciximab) during percutaneous coronary revascularization: Subgroup analysis from the epic trial Journal of Invasive Cardiology  1996 8:B21-B29
  • Challapalli, R., Lefkovits, J., Topol, E. J. Clinical trials of recombinant hirudin in acute coronary syndromes Coronary Artery Disease  1996 7:429-437  DOI:10.1097/00019501-199606000-00005  PMID:8889358
  • Rashid, J., Eisenberg, M. J., Topol, E. J. Cocaine-induced aortic dissection American Heart Journal  1996 132:1301-1304  DOI:10.1016/s0002-8703(96)90486-x  PMID:8969594
  • Weaver, W. D., White, H. D., Wilcox, R. G., Aylward, P. E., Morris, D., Guerci, A., Ohman, M., Barbash, G. I., Betriu, A., Sadowski, Z., Topol, E. J., Califf, R. M. Comparisons of characteristics and outcomes among women and men with acute myocardial infarction treated with thrombolytic therapy JAMA-Journal of the American Medical Association  1996 275:777-782  DOI:10.1001/jama.275.10.777  PMID:8598594
  • Pepine, C. J., Holmes, D. R., Block, P. C., Brinker, J. A., Mark, D. B., Mullins, C. E., Nissen, S. E., Topol, E. J., Williams, D. O., Goldberg, S., Hirshfeld, J. W., Serruys, P. W. Coronary artery stents Journal of the American College of Cardiology  1996 28:782-794  PMID:8772772
  • Mak, K. H., Eisenberg, M. J., Eccleston, D. S., Brown, K. J., Ellis, S. G., Topol, E. J. Cost-efficacy modeling of catheter reuse for percutaneous transluminal coronary angioplasty Journal of the American College of Cardiology  1996 28:106-111  DOI:10.1016/0735-1097(96)00097-6  PMID:8752801
  • Abdelmeguid, A. E., Ellis, S. G., Sapp, S. K., Whitlow, P. L., Topol, E. J. Defining the appropriate threshold of creatine kinase elevation after percutaneous coronary interventions American Heart Journal  1996 131:1097-1105  DOI:10.1016/s0002-8703(96)90083-6  PMID:8644587
  • Pilote, L., Miller, D. P., Califf, R. M., Rao, J. S., Weaver, W. D., Topol, E. J. Determinants of the use of coronary angiography and revascularization after thrombolysis for acute myocardial infarction New England Journal of Medicine  1996 335:1198-1205  DOI:10.1056/nejm199610173351606  PMID:8815943
  • Rao, A. K., Sun, L., Chesebro, J. H., Fuster, V., Harrington, R. A., Schwartz, D., Gallo, P., Matos, D., Topol, E. J. Distinct effects of recombinant desulfatohirudin (revasc) and heparin on plasma levels of fibrinopeptide a and prothrombin fragment f1.2 in unstable angina - a multicenter trial Circulation  1996 94:2389-2395  PMID:8921778
  • Newby, L. K., Califf, R. M., Guerci, A., Weaver, W. D., Col, J., Horgan, J. H., Mark, D. B., Stebbins, A., VandeWerf, F., Gore, J. M., Topol, E. J. Early discharge in the thrombolytic era: An analysis of criteria for uncomplicated infarction from the global utilization of streptokinase and t-pa for occluded coronary arteries (gusto) trial Journal of the American College of Cardiology  1996 27:625-632  PMID:8606274
  • Topol, E. J. Early myocardial reperfusion: An assessment of current strategies in acute myocardial infarction European Heart Journal  1996 17:42-48  PMID:11824003
  • Mark, D. B., Talley, J. D., Topol, E. J., Bowman, L., Lam, L. C., Anderson, K. M., Jollis, J. G., Cleman, M. W., Lee, K. L., Aversano, T., Untereker, W. J., DavidsonRay, L., et al. Economic assessment of platelet glycoprotein iib/iiia inhibition for prevention of ischemic complications of high-risk coronary angioplasty Circulation  1996 94:629-635  PMID:8772681
  • Holmes, D. R., Garratt, K. N., Isner, J. M., Kearney, M., Berdan, L. G., Schwartz, R. S., Califf, R. M., Topol, E. J. Effect of subintimal resection on initial outcome and restenosis for native coronary lesions and saphenous vein graft disease treated by directional coronary atherectomy - a report from the caveat i and ii investigators Journal of the American College of Cardiology  1996 28:645-651  DOI:10.1016/0735-1097(96)00185-4  PMID:8772751
  • Schulman, S. P., GoldschmidtClermont, P. J., Topol, E. J., Califf, R. M., Navetta, F. I., Willerson, J. T., Chandra, N. C., Guerci, A. D., Ferguson, J. J., Harrington, R. A., Lincoff, A. M., Yakubov, S. J., et al. Effects of integrelin, a platelet glycoprotein iib/iiia receptor antagonist, in unstable angina - a randomized multicenter trial Circulation  1996 94:2083-2089  PMID:8901655
  • Lefkovits, J., Ivanhoe, R. J., Califf, R. M., Bergelson, B. A., Anderson, K. M., Stoner, G. L., Weisman, H. F., Topol, E. J. Effects of platelet glycoprotein iib/iiia receptor blockade by a chimeric monoclonal antibody (abciximab) on acute and six-month outcomes after percutaneous transluminal coronary angioplasty for acute myocardial infarction American Journal of Cardiology  1996 77:1045-1051  DOI:10.1016/s0002-9149(96)00128-2  PMID:8644655
  • Sgarbossa, E. B., Pinski, S. L., Barbagelata, A., Underwood, D. A., Gates, K. B., Topol, E. J., Califf, R. M., Wagner, G. S. Electrocardiographic diagnosis of evolving acute myocardial infarction in the presence of left bundle-branch block New England Journal of Medicine  1996 334:481-487  DOI:10.1056/nejm199602223340801  PMID:8559200
  • LeBreton, H., Topol, E., Plow, E. F. Evidence for a pivotal role of platelets in vascular reocclusion and restenosis Cardiovascular Research  1996 31:235-236  DOI:10.1016/0008-6363(96)00005-3  PMID:8730399
  • Metz, B. K., Topol, E. J. Heparin as an adjuvant to thrombolytic therapy in acute myocardial infarction Biomedicine & Pharmacotherapy  1996 50:243-253  DOI:10.1016/0753-3322(96)84821-9  PMID:8952863
  • Lefkovits, J., Blankenship, J. C., Anderson, K. M., Stoner, G. L., Talley, J. D., Worley, S. J., Weisman, H. F., Califf, R. M., Topol, E. J. Increased risk of non-q wave myocardial infarction after directional atherectomy is platelet dependent: Evidence from the epic trial Journal of the American College of Cardiology  1996 28:849-855  DOI:10.1016/s0735-1097(96)00239-2  PMID:8837559
  • Redlitz, A., Nicolini, F. A., Malycky, J. L., Topol, E. J., Plow, E. F. Inducible carboxypeptidase activity - a role in clot lysis in vivo Circulation  1996 93:1328-1330  PMID:8641019
  • Langer, A., Goodman, S. G., Topol, E. J., Charlesworth, A., Skene, A. M., Wilcox, R. G., Armstrong, P. W. Late assessment of thrombolytic efficacy (late) study: Prognosis in patients with non-q wave myocardial infarction Journal of the American College of Cardiology  1996 27:1327-1332  DOI:10.1016/0735-1097(96)00012-5  PMID:8626939
  • Guzman, L. A., Labhasetwar, V., Song, C. X., Jang, Y. S., Lincoff, A. M., Levy, R., Topol, E. J. Local intraluminal infusion of biodegradable polymeric nanoparticles - a novel approach for prolonged drug delivery after balloon angioplasty Circulation  1996 94:1441-1448  PMID:8823004
  • vanderGiessen, W. J., Lincoff, A. M., Schwartz, R. S., vanBeusekom, H. M. M., Serruys, P. W., Holmes, D. R., Ellis, S. G., Topol, E. J. Marked inflammatory sequelae to implantation of biodegradable and nonbiodegradable polymers in porcine coronary arteries Circulation  1996 94:1690-1697  PMID:8840862
  • Califf, R. M., White, H. D., VandeWerf, E. V., Sadowski, Z., Armstrong, P. W., Vahanian, A., Simoons, M. L., Simes, R. J., Lee, K. L., Topol, E. J. One-year results from the global utilization of streptokinase and tpa for occluded coronary arteries (gusto-i) trial Circulation  1996 94:1233-1238  PMID:8822974
  • Omoigui, N. A., Miller, D. P., Brown, K. J., Annan, K., Cosgrove, D., Lytle, B., Loop, F., Topol, E. J. Outmigration for coronary bypass surgery in an era of public dissemination of clinical outcomes Circulation  1996 93:27-33  PMID:8616936
  • Lefkovits, J., Topol, E. J. Platelet glycoprotein IIb/IIIa receptor antagonists in coronary artery disease European Heart Journal  1996 17:9-18  PMID:8682137
  • Eisenberg, M. J., Topol, E. J. Prehospital administration of aspirin in patients with unstable angina and acute myocardial infarction Archives of Internal Medicine  1996 156:1506-1510  DOI:10.1001/archinte.156.14.1506  PMID:8687258
  • Peterson, E. D., Hathaway, W. R., Zabel, K. M., Pieper, K. S., Granger, C. B., Wagner, G. S., Topol, E. J., Bates, E. R., Simoons, M. L., Califf, R. M. Prognostic significance of precordial st segment depression during inferior myocardial infarction in the thrombolytic era: Results in 16,521 patients Journal of the American College of Cardiology  1996 28:305-312  DOI:10.1016/0735-1097(96)00133-7  PMID:8800102
  • Horrigan, M. C. G., MacIsaac, A. I., Nicolini, F. A., Vince, D. G., Lee, P., Ellis, S. G., Topol, E. J. Reduction in myocardial infarct size by basic fibroblast growth factor after temporary coronary occlusion in a canine model Circulation  1996 94:1927-1933  PMID:8873670
  • Obrien, J. E., Peterson, E. D., Keeler, G. P., Berdan, L. G., Ohman, E. M., Faxon, D. P., Jacobs, A. K., Topol, E. J., Califf, R. M. Relation between estrogen replacement therapy and restenosis after percutaneous coronary interventions Journal of the American College of Cardiology  1996 28:1111-1118  DOI:10.1016/s0735-1097(96)00306-3  PMID:8890803
  • Aylward, P. E., Wilcox, R. G., Horgan, J. H., White, H. D., Granger, C. B., Califf, R. M., Topol, E. J. Relation of increased arterial blood pressure to mortality and stroke in the context of contemporary thrombolytic therapy for acute myocardial infarction - a randomized trial Annals of Internal Medicine  1996 125:891-900  PMID:8967669
  • GottsaunerWolf, M., Moliterno, D. J., Lincoff, A. M., Topol, E. J. Restenosis - an open file Clinical Cardiology  1996 19:347-356  PMID:8723592
  • LeBreton, H., Plow, E. F., Topol, E. J. Role of platelets in restenosis after percutaneous coronary revascularization Journal of the American College of Cardiology  1996 28:1643-1651  PMID:8962547
  • Nicolini, F. A., Lee, P., Malycky, J. L., Lefkovits, J., KottkeMarchant, K., Plow, E. F., Topol, E. J. Selective inhibition of factor xa during thrombolytic therapy markedly improves coronary artery patency in a canine model of coronary thrombosis Blood Coagulation & Fibrinolysis  1996 7:39-48  DOI:10.1097/00001721-199601000-00005  PMID:8845461
  • Lefkovits, J., Malycky, J. L., Rao, J. S., Hart, C. E., Plow, E. F., Topol, E. J., Nicolini, F. A. Selective inhibition of factor xa is more efficient than factor viia-tissue factor complex blockade at facilitating coronary thrombolysis in the canine model Journal of the American College of Cardiology  1996 28:1858-1865  PMID:8962577
  • Abdelmeguid, A. E., Topol, E. J., Whitlow, P. L., Sapp, S. K., Ellis, S. G. Significance of mild transient release of creatine kinase-mb fraction after percutaneous coronary interventions Circulation  1996 94:1528-1536  PMID:8840840
  • Muller, D. W. M., Gordon, D., Topol, E. J., Levy, R. J., Golomb, G. Sustained-release local hirulog therapy decreases early thrombosis but not neointimal thickening after arterial stenting American Heart Journal  1996 131:211-218  DOI:10.1016/s0002-8703(96)90343-9  PMID:8579010
  • Lefkovits, J., Topol, E. J. The clinical role of platelet glycoprotein IIb/IIIa receptor inhibitors in ischemic heart disease Cleveland Clinic Journal of Medicine  1996 63:181-189  PMID:8665658
  • Barsness, G. W., Ohman, E. M., Califf, R. M., Kereiakes, D. J., George, B. S., Topol, E. J. The thrombolysis and angioplasty in myocardial infarction (tami) trials: A decade of reperfusion strategies Journal of Interventional Cardiology  1996 9:89-115  DOI:10.1111/j.1540-8183.1996.tb00604.x
  • Labinaz, M., Sketch, M. H., Stebbins, A. L., DeFranco, A. C., Holmes, D. R., Kleiman, N. S., Betriu, A., Rutsch, W. R., Vahanian, A., Topol, E. J., Califf, R. M. Thrombolytic therapy for patients with prior percutaneous transluminal coronary angioplasty and subsequent acute myocardial infarction American Journal of Cardiology  1996 78:1338-1344  DOI:10.1016/s0002-9149(96)00654-6  PMID:8970403
  • Newby, L. K., Rutsch, W. R., Califf, R. M., Simoons, M. L., Aylward, P. E., Armstrong, P. W., Woodlief, L. H., Lee, K. L., Topol, E. J., VandeWerf, F. Time from symptom onset to treatment and outcomes after thrombolytic therapy Journal of the American College of Cardiology  1996 27:1646-1655  PMID:8636549
  • Pichard, A., Ivanhoe, R., Satler, L., Masden, R., Chapekis, A., Lee, K. L., Reen, B., Levine, G., Abbottsmith, C., Gottlieb, R. S., Stillabower, M., Chambers, J., et al. A multicenter, randomized trial of coronary angioplasty versus directional atherectomy for patients with saphenous vein bypass graft lesions Circulation  1995 91:1966-1974  PMID:7895354
  • Holmes, D. R., Simpson, J. B., Berdan, L. G., Gottlieb, R. S., Leya, F., Keeler, G. P., Califf, R. M., Topol, E. J. Abrupt closure - the caveat-i experience Journal of the American College of Cardiology  1995 26:1494-1500  DOI:10.1016/0735-1097(95)00339-8  PMID:7594076
  • Silver, M. J., Sutton, J. M., Hook, S., Lee, P., Malycky, J. L., Phillips, M. L., Ellis, S. G., Topol, E. J., Nicolini, F. A. Adjunctive selectin blockade successfully reduces infarct size beyond thrombolysis in the electrolytic canine coronary-artery model Circulation  1995 92:492-499  PMID:7543381
  • Califf, R. M., Lincoff, A. M., Tcheng, J. E., Topol, E. J. An overview of the results of the EPIC trial European Heart Journal  1995 16:43-49  PMID:8869018
  • Gersh, B. J., Topol, E. J. Angioplasty or thrombolysis in acute myocardial-infarction - dilate or dissolve Cleveland Clinic Journal of Medicine  1995 62:15-19  PMID:7859398
  • Aguirre, F. V., Topol, E. J., Ferguson, J. J., Anderson, K., Blankenship, J. C., Heuser, R. R., Sigmon, K., Taylor, M., Gottlieb, R., Hanovich, G., Rosenberg, M., Donohue, T. J., et al. Bleeding complications with the chimeric antibody to platelet glycoprotein iib/iiia integrin in patients undergoing percutaneous coronary intervention Circulation  1995 91:2882-2890  PMID:7796496
  • Becker, R. C., Charlesworth, A., Wilcox, R. G., Hampton, J., Skene, A., Gore, J. M., Topol, E. J. Cardiac rupture associated with thrombolytic therapy - impact of time to treatment in the late assessment of thrombolytic efficacy (late) study Journal of the American College of Cardiology  1995 25:1063-1068  DOI:10.1016/0735-1097(94)00524-t  PMID:7897117
  • Harrington, R. A., Lincoff, A. M., Califf, R. M., Holmes, D. R., Berdan, L. G., Ohanesian, M. A., Keeler, G. P., Garratt, K. N., Ohman, E. M., Mark, D. B., Jacobs, A. K., Topol, E. J. Characteristics and consequences of myocardial-infarction after percutaneous coronary intervention - insights from the coronary angioplasty versus excisional atherectomy trial (caveat) Journal of the American College of Cardiology  1995 25:1693-1699  DOI:10.1016/0735-1097(95)00091-h  PMID:7759725
  • Holmes, D. R., Bates, E. R., Kleiman, N. S., Sadowski, Z., Horgan, J. H. S., Morris, D. C., Califf, R. M., Berger, P. B., Topol, E. J. Contemporary reperfusion therapy for cardiogenic-shock - the gusto-i trial experience Journal of the American College of Cardiology  1995 26:668-674  DOI:10.1016/0735-1097(95)00215-p  PMID:7642857
  • Williams, D. O., Baim, D. S., Bates, E., Bonan, R., Bost, J. E., Cowley, M., Faxon, D. P., Feit, F., Jones, R., Kellett, M. A., Kelsey, S. F., Sopko, G., et al. Coronary anatomic and procedural characteristics of patients randomized to coronary angioplasty in the bypass angioplasty revascularization investigation (bari) American Journal of Cardiology  1995 75:C27-C33  DOI:10.1016/s0002-9149(99)80392-0
  • Mark, D. B., Hlatky, M. A., Califf, R. M., Naylor, C. D., Lee, K. L., Armstrong, P. W., Barbash, G., White, H., Simoons, M. L., Nelson, C. L., Clappchanning, N., Knight, J. D., et al. Cost-effectiveness of thrombolytic therapy with tissue-plasminogen activator as compared with streptokinase for acute myocardial-infarction New England Journal of Medicine  1995 332:1418-1424  DOI:10.1056/nejm199505253322106  PMID:7723799
  • Christenson, R. H., Ohman, E. M., Topol, E. J., Ohanesian, M. A., Sigmon, K. N., Duh, S. H., Kereiakes, D., Worley, S. J., George, B. S., Pizzo, C. K., Wall, T. C., Califf, R. M. Creatine-kinase mm and mb isoforms in patients receiving thrombolytic therapy and acute angiography Clinical Chemistry  1995 41:844-852  PMID:7768002
  • Boehrer, J. D., Ellis, S. G., Pieper, K., Holmes, D. R., Keeler, G. P., Debowey, D., Chapekis, A. T., Leya, F., Mooney, M. R., Gottlieb, R. S., Serruys, P. W., Califf, R. M., et al. Directional atherectomy versus balloon angioplasty for coronary ostial and nonostial left anterior descending coronary-artery lesions - results from a randomized multicenter trial Journal of the American College of Cardiology  1995 25:1380-1386  DOI:10.1016/0735-1097(95)00008-r  PMID:7722137
  • Grines, C. L., Topol, E. J., Oneill, W. W., George, B. S., Kereiakes, D., Phillips, H. R., Leimberger, J. D., Woodlief, L. H., Califf, R. M. Effect of cigarette-smoking on outcome after thrombolytic therapy for myocardial-infarction Circulation  1995 91:298-303  PMID:7805231
  • Moliterno, D. J., Califf, R. M., Aguirre, F. V., Anderson, K., Sigmon, K. N., Weisman, H. F., Topol, E. J. Effect of platelet glycoprotein iib/iiia integrin blockade on activated clotting time during percutaneous transluminal coronary angioplasty or directional atherectomy (the epic trial) American Journal of Cardiology  1995 75:559-562  DOI:10.1016/s0002-9149(99)80616-x  PMID:7887377
  • Villa, A. E., Guzman, L. A., Poptic, E. J., Labhasetwar, V., Dsouza, S., Farrell, C. L., Plow, E. F., Levy, R. J., Dicorleto, P. E., Topol, E. J. Effects of antisense c-myb oligonucleotides on vascular smooth-muscle cell-proliferation and response to vessel wall injury Circulation Research  1995 76:505-513  PMID:7895327
  • Barbash, G. I., Reiner, J., White, H. D., Wilcox, R. G., Armstrong, P. W., Sadowski, Z., Morris, D., Aylward, P., Woodlief, L. H., Topol, E. J., Califf, R. M., Ross, A. M. Evaluation of paradoxic beneficial-effects of smoking in patients receiving thrombolytic therapy for acute myocardial-infarction - mechanism of the smokers paradox from the gusto-i trial, with angiographic insights Journal of the American College of Cardiology  1995 26:1222-1229  DOI:10.1016/0735-1097(95)00299-5  PMID:7594035
  • Barbagelata, A., Granger, C. B., Topol, E. J., Worley, S. J., Kereiakes, D. J., George, B. S., Ohman, E. M., Leimberger, J. D., Mark, D. B., Califf, R. M. Frequency, significance, and cost of recurrent ischemia after thrombolytic therapy for acute myocardial-infarction American Journal of Cardiology  1995 76:1007-1013  DOI:10.1016/s0002-9149(99)80285-9  PMID:7484852
  • Robinson, K., Mayer, E. L., Miller, D. P., Green, R., Vanlente, F., Gupta, A., Kottkemarchant, K., Savon, S. R., Selhub, J., Nissen, S. E., Kutner, M., Topol, E. J. Hyperhomocysteinemia and low pyridoxal-phosphate - common and independent reversible risk-factors for coronary-artery disease Circulation  1995 92:2825-2830  PMID:7586248
  • Harrington, R. A., Kleiman, N. S., Kottkemarchant, K., Lincoff, A. M., Tcheng, J. E., Sigmon, K. N., Joseph, D., Rios, G., Trainor, K., Rose, D., Greenberg, C. S., Kitt, M. M., et al. Immediate and reversible platelet inhibition after intravenous administration of a peptide glycoprotein iib/iiia inhibitor during percutaneous coronary intervention American Journal of Cardiology  1995 76:1222-1227  DOI:10.1016/s0002-9149(99)80345-2  PMID:7503000
  • Ellis, S. G., Miller, D. P., Brown, K. J., Omoigui, N., Howell, G. L., Kutner, M., Topol, E. J. In-hospital cost of percutaneous coronary revascularization - critical determinants and implications Circulation  1995 92:741-747  PMID:7641352
  • Jang, Y. S., Guzman, L. A., Lincoff, A. M., Gottsaunerwolf, M., Forudi, F., Hart, C. E., Courtman, D. W., Ezban, M., Ellis, S. G., Topol, E. J. Influence of blockade at specific levels of the coagulation cascade on restenosis in a rabbit atherosclerotic femoral-artery injury model Circulation  1995 92:3041-3050  PMID:7586275
  • Eccleston, D., Topol, E. J. Inhibitors of platelet glycoprotein IIb/IIIa as augmenters of thrombolysis Coronary Artery Disease  1995 6:947-955  PMID:8723017
  • Holmes, D. R., Califf, R. M., Topol, E. J. Lessons we have learned from the gusto trial Journal of the American College of Cardiology  1995 25:S10-S17  DOI:10.1016/0735-1097(95)90011-x
  • Simes, R. J., Topol, E. J., Holmes, D. R., White, H. D., Rutsch, W. R., Vahanian, A., Simoons, M. L., Morris, D., Betriu, A., Califf, R. M., Ross, A. M. Link between the angiographic substudy and mortality outcomes in a large randomized trial of myocardial reperfusion - importance of early and complete infarct artery reperfusion Circulation  1995 91:1923-1928  PMID:7895348
  • Abdelmeguid, A. E., Whitlow, P. L., Sapp, S. K., Ellis, S. G., Topol, E. J. Long-term outcome of transient, uncomplicated in-laboratory coronary artery closure Circulation  1995 91:2733-2741  PMID:7758178
  • Lefkovits, J., Plow, E. F., Topol, E. J. Mechanisms of disease - platelet glycoprotein IIb/IIIa receptors in cardiovascular medicine New England Journal of Medicine  1995 332:1553-1559  PMID:7739710
  • Smalling, R. W., Bode, C., Kalbfleisch, J., Sen, S., Limbourg, P., Forycki, F., Habib, G., Feldman, R., Hohnloser, S., Seals, A., Califf, R., Guerci, A., et al. More rapid, complete, and stable coronary thrombolysis with bolus administration of reteplase compared with alteplase infusion in acute myocardial infarction Circulation  1995 91:2725-2732  PMID:7758177
  • Tcheng, J. E., Harrington, R. A., Kottkemarchant, K., Kleiman, N. S., Ellis, S. G., Kereiakes, D. J., Mick, M. J., Navetta, F. I., Smith, J. E., Worley, S. J., Miller, J. A., Joseph, D. M., et al. Multicenter, randomized, double-blind, placebo-controlled trial of the platelet integrin glycoprotein iib/iiia blocker integrelin in elective coronary intervention Circulation  1995 91:2151-2157  PMID:7697843
  • Topol, E. J. Novel antithrombotic approaches to coronary-artery disease American Journal of Cardiology  1995 75:B27-B33  DOI:10.1016/0002-9149(95)80007-f
  • Omoigui, N. A., Topol, E. J. Observational versus randomized medical device testing before and after market approval - the atherectomy-versus-angioplasty controversy Controlled Clinical Trials  1995 16:143-149  DOI:10.1016/0197-2456(95)00035-f  PMID:7796597
  • Elliott, J. M., Berdan, L. G., Holmes, D. R., Isner, J. M., King, S. B., Keeler, G. P., Kearney, M., Califf, R. M., Topol, E. J. One-year follow-up in the coronary angioplasty versus excisional atherectomy trial (caveat-i) Circulation  1995 91:2158-2166  PMID:7697844
  • Topol, E. J., Nissen, S. E. Our preoccupation with coronary luminology - the dissociation between clinical and angiographic findings in ischemic-heart-disease Circulation  1995 92:2333-2342  PMID:7554219
  • Abdelmeguid, A. E., Whitlow, P. L., Simpfendorfer, C., Sapp, S. K., Franco, I., Ellis, S. G., Topol, E. J. Percutaneous revascularization of ostial saphenous-vein graft stenoses Journal of the American College of Cardiology  1995 26:955-960  DOI:10.1016/0735-1097(95)00266-x  PMID:7560623
  • Omoigui, N. A., Califf, R. M., Pieper, K., Keeler, G., Ohanesian, M. A., Berdan, L. G., Mark, D. B., Talley, J. D., Topol, E. J. Peripheral vascular complications in the coronary angioplasty versus excisional atherectomy trial (caveat-i) Journal of the American College of Cardiology  1995 26:922-930  DOI:10.1016/0735-1097(95)00263-4  PMID:7560619
  • Lefkovits, J., Topol, E. J. Platelet glycoprotein iib/iiia receptor inhibitors in ischemic-heart-disease Current Opinion in Cardiology  1995 10:420-426  DOI:10.1097/00001573-199507000-00012  PMID:7549085
  • Lefkovits, J., Holmes, D. R., Califf, R. M., Safian, R. D., Pieper, K., Keeler, G., Topol, E. J. Predictors and sequelae of distal embolization during saphenous-vein graft intervention from the caveat-ii trial Circulation  1995 92:734-740  PMID:7641351
  • Lee, K. L., Woodlief, L. H., Topol, E. J., Weaver, W. D., Betriu, A., Col, J., Simoons, M., Aylward, P., Vandewerf, F., Califf, R. M. Predictors of 30-day mortality in the era of reperfusion for acute myocardial-infarction - results from an international trial of 41 021 patients Circulation  1995 91:1659-1668  PMID:7882472
  • Topol, E. J. Prevention of cardiovascular ischemic complications with new platelet glycoprotein IIb/IIIa inhibitors American Heart Journal  1995 130:666-672  DOI:10.1016/0002-8703(95)90304-6  PMID:7668215
  • Ellis, S. G., Cowley, M. J., Whitlow, P. L., Vandormael, M., Lincoff, A. M., Disciascio, G., Dean, L. S., Topol, E. J. Prospective case-control comparison of percutaneous transluminal coronary revascularization in patients with multivessel disease treated in 1986-1987 versus 1991 - improved in-hospital and 12-month results Journal of the American College of Cardiology  1995 25:1137-1142  DOI:10.1016/0735-1097(94)00541-w  PMID:7897127
  • Moliterno, D. J., Elliott, J. M., Topol, E. J. Randomized trials of myocardial revascularization Current Problems in Cardiology  1995 20:128-190  DOI:10.1016/s0146-2806(06)80025-3
  • Pilote, L., Califf, R. M., Sapp, S., Miller, D. P., Mark, D. B., Weaver, W. D., Gore, J. M., Armstrong, P. W., Ohman, E. M., Topol, E. J. Regional variation across the united-states in the management of acute myocardial-infarction New England Journal of Medicine  1995 333:565-572  DOI:10.1056/nejm199508313330907  PMID:7623907
  • Guzman, L. A., Forudi, F., Villa, A. E., Topol, E. J. Role of leukocytes in neointimal formation after balloon angioplasty in the rabbit atherosclerotic model Coronary Artery Disease  1995 6:693-701  PMID:8747874
  • Lincoff, A. M., Topol, E. J., Califf, R. M., Sigmon, K. N., Lee, K. L., Ohman, E. M., Rosenschein, U., Ellis, S. G. Significance of a coronary-artery with thrombolysis in myocardial-infarction grade-2 flow patency (outcome in the thrombolysis and angioplasty in myocardial-infarction trials) American Journal of Cardiology  1995 75:871-876  DOI:10.1016/s0002-9149(99)80678-x  PMID:7732992
  • Gore, J. M., Granger, C. B., Simoons, M. L., Sloan, M. A., Weaver, D., White, H. D., Barbash, G. I., Vandewerf, F., Aylward, P. E., Topol, E. J., Califf, R. M. Stroke after thrombolysis - mortality and functional outcomes in the gusto-i trial Circulation  1995 92:2811-2818  PMID:7586246
  • Karnash, S. L., Granger, C. B., White, H. D., Woodlief, L. H., Topol, E. J., Califf, R. M. Treating menstruating women with thrombolytic therapy - insights from the global utilization of streptokinase and tissue-plasminogen activator for occluded coronary-arteries (gusto-i) trial Journal of the American College of Cardiology  1995 26:1651-1656  DOI:10.1016/0735-1097(95)00386-x  PMID:7594099
  • Vandewerf, F., Topol, E. J., Lee, K. L., Woodlief, L. H., Granger, C. B., Armstrong, P. W., Barbash, G. I., Hampton, J. R., Guerci, A., Simes, R. J., Ross, A. M., Califf, R. M. Variations in patient-management and outcomes for acute myocardial-infarction in the united-states and other countries - results from the gusto trial JAMA-Journal of the American Medical Association  1995 273:1586-1591  DOI:10.1001/jama.273.20.1586  PMID:7745771
  • Nissen, S. E., Pepine, C. J., Bashore, T. M., Block, P. C., Bonchek, L. I., Brinker, J. A., Carabello, B., Douglas, J. S., Elion, J. L., Hirshfeld, J. W., Holmes, D. R., Johnson, W. L., et al. Cardiac angiography without cine film - erecting a tower-of-babel in the cardiac-catheterization laboratory Journal of the American College of Cardiology  1994 24:834-837  PMID:8077561
  • Jang, Y. S., Lincoff, A. M., Plow, E. F., Topol, E. J. Cell-adhesion molecules in coronary-artery disease Journal of the American College of Cardiology  1994 24:1591-1601  PMID:7963103
  • Harrington, R. A., Sane, D. C., Califf, R. M., Sigmon, K. N., Abbottsmith, C. W., Candela, R. J., Lee, K. L., Topol, E. J. Clinical importance of thrombocytopenia occurring in the hospital phase after administration of thrombolytic therapy for acute myocardial-infarction Journal of the American College of Cardiology  1994 23:891-898  PMID:8106694
  • Nicolini, F. A., Lee, P., Rios, G., Kottkemarchant, K., Topol, E. J. Combination of platelet fibrinogen receptor antagonist and direct thrombin inhibitor at low-doses markedly improves thrombolysis Circulation  1994 89:1802-1809  PMID:8149546
  • Maclsaac, A. I., Ellis, S. G., Muller, D. W., Topol, E. J., Whitlow, P. L. Comparison of 3 coronary stents - clinical and angiographic outcome after elective placement in 134 consecutive patients Catheterization and Cardiovascular Diagnosis  1994 33:199-204  DOI:10.1002/ccd.1810330302  PMID:7874711
  • Rosenschein, U., Ellis, S. G., Haudenschild, C. C., Yakubov, S. J., Muller, D. W. M., Dick, R. J., Topol, E. J. Comparison of histopathologic coronary lesions obtained from directional atherectomy in stable angina versus acute coronary syndromes American Journal of Cardiology  1994 73:508-510  DOI:10.1016/0002-9149(94)90683-1  PMID:8141093
  • Paranandi, S. N., Topol, E. J. Contemporary clinical-trials of restenosis Journal of Invasive Cardiology  1994 6:109-124  PMID:10147167
  • Braunwald, E., Jones, R. H., Mark, D. B., Brown, J., Brown, L., Cheitlin, M. D., Concannon, C. A., Cowan, M., Edwards, C., Fuster, V., Goldman, L., Green, L. A., et al. Diagnosing and managing unstable angina Circulation  1994 90:613-622  PMID:8026048
  • Holmes, D. R., Topol, E. J. Dilate or debulk Cleveland Clinic Journal of Medicine  1994 61:124-126  PMID:8194176
  • Lefkovits, J., Topol, E. J. Direct thrombin inhibitors in cardiovascular medicine Circulation  1994 90:1522-1536  PMID:8087958
  • Reiner, J. S., Lundergan, C. F., Vandenbrand, M., Boland, J., Thompson, M. A., Machecourt, J., Py, A., Pilcher, G. S., Fink, C. A., Burton, J. R., Simoons, M. L., Califf, R. M., et al. Early angiography cannot predict postthrombolytic coronary reocclusion - observations from the gusto angiographic study Journal of the American College of Cardiology  1994 24:1439-1444  PMID:7930273
  • Boehrer, J. D., Kereiakes, D. J., Navetta, F. I., Califf, R. M., Topol, E. J. Effects of profound platelet inhibition with c7e3 before coronary angioplasty on complications of coronary-bypass survey American Journal of Cardiology  1994 74:1166-1170  DOI:10.1016/0002-9149(94)90474-x  PMID:7977081
  • Steinberg, J. S., Hochman, J. S., Morgan, C. D., Dorian, P., Naylor, C. D., Theroux, P., Topol, E. J., Armstrong, P. W. Effects of thrombolytic therapy administered 6 to 24 hours after myocardial-infarction on the signal-averaged ecg - results of a multicenter randomized trial Circulation  1994 90:746-752  PMID:8044943
  • Lefkovits, J., Topol, E. J. Future-directions in thrombolysis for myocardial-infarction - what are the unanswered questions Coronary Artery Disease  1994 5:306-316  DOI:10.1097/00019501-199404000-00006  PMID:8044342
  • Lee, K. L., Califf, R. M., Simes, J., Vandewerf, F., Topol, E. J. Holding gusto up to the light Annals of Internal Medicine  1994 120:876-881  PMID:8154647
  • Kawai, C., Simoons, M. L., Baigent, C., Lenert, L. A., Collins, R., Lopezsendon, J., Parish, S., Knatterud, G., Visani, L., Halls, H., Nicklas, J., Mead, G., et al. Indications for fibrinolytic therapy in suspected acute myocardial infarction - collaborative overview of early mortality and major morbidity results from all randomized trials of more than 1000 patients Lancet  1994 343:311-322  PMID:7905143
  • Wall, T. C., Califf, R. M., Blankenship, J., Talley, J. D., Tannenbaum, M., Schwaiger, M., Gacioch, G., Cohen, M. D., Sanz, M., Leimberger, J. D., Topol, E. J. Intravenous fluosol in the treatment of acute myocardial-infarction - results of the thrombolysis and angioplasty in myocardial-infarction-9 trial Circulation  1994 90:114-120  PMID:8025985
  • Defranco, A. C., Topol, E. J. Invasive strategies for acute myocardial-infarction in the elderly Cardiology in the Elderly  1994 2:274-289
  • Villa, A. E., Guzman, L. A., Chen, W. L., Golomb, G., Levy, R. J., Topol, E. J. Local-delivery of dexamethasone for prevention of neointimal proliferation in a rat model of balloon angioplasty Journal of Clinical Investigation  1994 93:1243-1249  DOI:10.1172/jci117078  PMID:8132764
  • Lincoff, A. M., Topol, E. J., Ellis, S. G. Local-drug delivery for the prevention of restenosis - fact, fancy, and future Circulation  1994 90:2070-2084  PMID:7923695
  • Savage, M. P., Fischman, D. L., Schatz, R. A., Teirstein, P. S., Leon, M. B., Baim, D., Ellis, S. G., Topol, E. J., Hirshfeld, J. W., Cleman, M. W., Buchbinder, M., Bailey, S., et al. Long-term angiographic and clinical outcome after implantation of a balloon-expandable stent in the native coronary circulation Journal of the American College of Cardiology  1994 24:1207-1212  PMID:7930240
  • Faxon, D. P., Spiro, T. E., Minor, S., Cote, G., Douglas, J., Gottlieb, R., Califf, R., Dorosti, K., Topol, E., Gordon, J. B., Ohmen, M., Raizner, A., et al. Low-molecular-weight heparin in prevention of restenosis after angioplasty - results of enoxaparin restenosis (era) trial Circulation  1994 90:908-914  PMID:8044962
  • Sutton, J. M., Ellis, S. G., Roubin, G. S., Pinkerton, C. A., King, S. B., Raizner, A. E., Holmes, D. R., Kereiakes, D. J., Topol, E. J. Major clinical events after coronary stenting - the multicenter registry of acute and elective gianturco-roubin stent placement Circulation  1994 89:1126-1137  PMID:8124799
  • Hicks, R. J., Melon, P., Kalff, V., Wolfe, E., Dick, R. J., Popma, J. J., Topol, E., Schwaiger, M. Metabolic imaging by positron emission tomography early after myocardial-infarction as a predictor of recovery of myocardial-function after reperfusion Journal of Nuclear Cardiology  1994 1:124-137  DOI:10.1007/bf02984084  PMID:9420679
  • Kleiman, N. S., White, H. D., Ohman, E. M., Ross, A. M., Woodlief, L. H., Califf, R. M., Holmes, D. R., Bates, E., Pfisterer, M., Vahanian, A., Topol, E. J. Mortality within 24 hours of thrombolysis for myocardial-infarction - the importance of early reperfusion Circulation  1994 90:2658-2665  PMID:7994805
  • Tcheng, J. E., Ellis, S. G., George, B. S., Kereiakes, D. J., Kleiman, N. S., Talley, J. D., Wang, A. L., Weisman, H. F., Califf, R. M., Topol, E. J. Pharmacodynamics of chimeric glycoprotein iib/iiia integrin antiplatelet antibody fab 7e3 in high-risk coronary angioplasty Circulation  1994 90:1757-1764  PMID:7923659
  • Brown, D. L., Macisaac, A. I., Topol, E. J. Pulmonary hemorrhage after intracoronary stent placement Journal of the American College of Cardiology  1994 24:91-94  PMID:8006287
  • Ellis, S. G., Dasilva, E. R., Heyndrickx, G., Talley, J. D., Cernigliaro, C., Steg, G., Spaulding, C., Nobuyoshi, M., Erbel, R., Vassanelli, C., Topol, E. J. Randomized comparison of rescue angioplasty with conservative management of patients with early failure of thrombolysis for acute anterior myocardial-infarction Circulation  1994 90:2280-2284  PMID:7955184
  • Ellis, S. G., Lincoff, A. M., George, B. S., Kereiakes, D. J., Ohman, E. M., Krucoff, M. W., Califf, R. M., Topol, E. J. Randomized evaluation of coronary angioplasty for early timi-2 flow after thrombolytic therapy for the treatment of acute myocardial-infarction - a new look at an old study Coronary Artery Disease  1994 5:611-615  DOI:10.1097/00019501-199407000-00009  PMID:7952423
  • Topol, E. J., Califf, R. M., Weisman, H. F., Ellis, S. G., Tcheng, J. E., Worley, S., Ivanhoe, R., George, B. S., Fintel, D., Weston, M., Sigmon, K., Anderson, K. M., et al. Randomized trial of coronary intervention with antibody against platelet iib/iiia integrin for reduction of clinical restenosis - results at 6 months Lancet  1994 343:881-886  DOI:10.1016/s0140-6736(94)90007-8  PMID:7908357
  • Topol, E., Califf, R., Vandewerf, F., Ardissino, D., Armstrong, P., Aylward, P., Barbash, G., Bates, E., Beatt, K., Betriu, A., Chesebro, J., Col, J., et al. Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes Circulation  1994 90:1631-1637  PMID:7923645
  • Vandewerf, F., Santopinto, J., Cordero, F. A., Fainstein, D., Corinaldesi, A., Zavatti, D., Luppi, O., Iparraguirre, H. P., Hirschson, A., Piombo, A., Lapuente, A., Kritzer, J., et al. Randomized trial of ridogrel, a combined thromboxane a(2) synthase inhibitor and thromboxane a(2)/prostaglandin endoperoxide receptor antagonist, versus aspirin as adjunct to thrombolysis in patients with acute myocardial-infarction - the ridogrel versus aspirin patency trial (rapt) Circulation  1994 89:588-595  PMID:8313547
  • Holmes, D. R., Topol, E. J., Adelman, A. G., Cohen, E. A., Califf, R. M. Randomized trials of directional coronary atherectomy - implications for clinical-practice and future investigation Journal of the American College of Cardiology  1994 24:431-439  PMID:8034880
  • Topol, E. J., Fuster, V., Harrington, R. A., Califf, R. M., Kleiman, N. S., Kereiakes, D. J., Cohen, M., Chapekis, A., Gold, H. K., Tannenbaum, M. A., Rao, A. K., Debowey, D., et al. Recombinant hirudin for unstable angina-pectoris - a multicenter, randomized angiographic trial Circulation  1994 89:1557-1566  PMID:8149521
  • Flaherty, J. T., Pitt, B., Gruber, J. W., Heuser, R. R., Rothbaum, D. A., Burwell, L. R., George, B. S., Kereiakes, D. J., Deitchman, D., Gustafson, N., Brinker, J. A., Becker, L. C., et al. Recombinant human superoxide-dismutase (h-sod) fails to improve recovery of ventricular-function in patients undergoing coronary angioplasty far acute myocardial-infarction Circulation  1994 89:1982-1991  PMID:8181121
  • Ellis, S. G., Popma, J. J., Buchbinder, M., Franco, I., Leon, M. B., Kent, K. M., Pichard, A. D., Satler, L. F., Topol, E. J., Whitlow, P. L. Relation of clinical presentation, stenosis morphology, and operator technique to the procedural results of rotational atherectomy and rotational atherectomy-facilitated angioplasty Circulation  1994 89:882-892  PMID:8313578
  • Topol, E. J., Califf, R. M. Scorecard cardiovascular medicine - its impact and future-directions Annals of Internal Medicine  1994 120:65-70  PMID:8250458
  • Sgarbossa, E. B., Topol, E. J. Semantic ambiguity, the non-nosology and myocardial-infarction Journal of Clinical Epidemiology  1994 47:441-446  DOI:10.1016/0895-4356(94)90165-1  PMID:7730869
  • Califf, R. M., Shadoff, N., Valett, N., Bates, E., Galeana, A., Knopf, W., Shaftel, J., Bender, M. J., Aversano, T., Raqueno, J., Gurbel, P., Cowfer, J., et al. Use of a monoclonal-antibody directed against the platelet glycoprotein iib/iiia receptor in high-risk coronary angioplasty New England Journal of Medicine  1994 330:956-961  PMID:8121459
  • Mark, D. B., Naylor, C. D., Hlatky, M. A., Califf, R. M., Topol, E. J., Granger, C. B., Knight, J. D., Nelson, C. L., Lee, K. L., Clappchanning, N. E., Sutherland, W., Pilote, L., et al. Use of medical resources and quality-of-life after acute myocardial-infarction in canada and the united-states New England Journal of Medicine  1994 331:1130-1135  DOI:10.1056/nejm199410273311706  PMID:7935638
  • Topol, E. J., Leya, F., Pinkerton, C. A., Whitlow, P. L., Hofling, B., Simonton, C. A., Masden, R. R., Serruys, P. W., Leon, M. B., Williams, D. O., King, S. B., Mark, D. B., et al. A comparison of directional atherectomy with coronary angioplasty in patients with coronary-artery disease New England Journal of Medicine  1993 329:221-227  DOI:10.1056/nejm199307223290401  PMID:8316266
  • Ohman, E. M., Topol, E. J., Califf, R. M., Bates, E. R., Ellis, S. G., Kereiakes, D. J., George, B. S., Samaha, J. K., Kline, E., Sigmon, K. N., Stack, R. S. An analysis of the cause of early mortality after administration of thrombolytic therapy Coronary Artery Disease  1993 4:957-964  DOI:10.1097/00019501-199311000-00002  PMID:8173712
  • Topol, E., Califf, R., Vandewerf, F., Armstrong, P. W., Aylward, P., Barbash, G., Bates, E., Betriu, A., Boissel, J. P., Chesebro, J., Col, J., Debono, D., et al. An international randomized trial comparing 4 thrombolytic strategies for acute myocardial-infarction New England Journal of Medicine  1993 329:673-682  PMID:8204123
  • Topol, E. J., Ellis, S. G., Cosgrove, D. M., Bates, E. R., Muller, D. W. M., Schork, N. J., Schork, M. A., Loop, F. D. Analysis of coronary angioplasty practice in the united-states with an insurance-claims data-base Circulation  1993 87:1489-1497  PMID:8141866
  • Lee, K. S., Topol, E. J., Stewart, W. J. Atypical presentation of papillary fibroelastoma mimicking multiple vegetations in suspected subacute bacterial-endocarditis American Heart Journal  1993 125:1443-1445  DOI:10.1016/0002-8703(93)91025-a  PMID:8480605
  • Defeyter, Pimj, Vansuylen, R. J., Dejaegere, P. P. T., Topol, E. J., Serruys, P. W. Balloon angioplasty for the treatment of lesions in saphenous-vein bypass grafts Journal of the American College of Cardiology  1993 21:1539-1549  PMID:8496517
  • Topol, E. J. Breaking the thrombolytic gridlock - insights from the gusto trial Cleveland Clinic Journal of Medicine  1993 60:445-447  PMID:8287504
  • Topol, E. J., Plow, E. F. Clinical-trials of platelet receptor inhibitors Thrombosis and Haemostasis  1993 70:94-98  PMID:8236122
  • Casale, P. N., Whitlow, P. L., Franco, I., Grigera, F., Pashkow, F. J., Topol, E. J. Comparison of major complication rates with new atherectomy devices for percutaneous coronary intervention in women versus men American Journal of Cardiology  1993 71:1221-1223  DOI:10.1016/0002-9149(93)90650-2  PMID:8480650
  • Krucoff, M. W., Croll, M. A., Pope, J. E., Granger, C. B., Oconnor, C. M., Sigmon, K. N., Wagner, B. L., Ryan, J. A., Lee, K. L., Kereiakes, D. J., Samaha, J. K., Worley, S. J., et al. Continuous 12-lead st-segment recovery analysis in the tami 7 study - performance of a noninvasive method for real-time detection of failed myocardial reperfusion Circulation  1993 88:437-446  PMID:8339407
  • Sane, D. C., Califf, R. M., Sigmon, K. N., Topol, E. J., Stump, D. C. Effect of heparin administration on fibrinogenolysis during thrombolytic therapy with tissue plasminogen activator for acute myocardial infarction Fibrinolysis  1993 7:103-107  DOI:10.1016/0268-9499(93)90030-y
  • Nath, F. C., Muller, D. W. M., Rosenschein, U., Ellis, S. G., Topol, E. J. Heparin monitoring during coronary intervention - activated clotting time versus activated partial thromboplastin time Canadian Journal of Cardiology  1993 9:797-801  PMID:8281479
  • Lincoff, A. M., Topol, E. J. Illusion of reperfusion. Does anyone achieve optimal reperfusion during acute myocardial infarction? Circulation  1993 87:1792-1805  PMID:8353902
  • Lincoff, A. M., Topol, E. J., Chapekis, A. T., George, B. S., Candela, R. J., Muller, D. W. M., Zimmerman, C. A., Ellis, S. G. Intracoronary stenting compared with conventional therapy for abrupt vessel closure complicating coronary angioplasty - a matched case-control study Journal of the American College of Cardiology  1993 21:866-875  PMID:8450155
  • Cowley, M. J., Vandermael, M., Topol, E. J., Whitlow, P. L., Dean, L. S., Bulle, T. M., Ellis, S. G. Is traditionally defined complete revascularization needed for patients with multivessel disease treated by elective coronary angioplasty Journal of the American College of Cardiology  1993 22:1289-1297  PMID:8227782
  • Wall, T. C., Califf, R. M., Ellis, S. G., Sigmon, K., Kereiakes, D., George, B. S., Samaha, J., Sane, D., Stump, D. C., Stack, R. S., Topol, E. J. Lack of impact of early catheterization and fibrin specificity on bleeding complications after thrombolytic therapy Journal of the American College of Cardiology  1993 21:597-603  PMID:8436740
  • Bernardi, M. M., Califf, R. M., Kleiman, N., Ellis, S. G., Topol, E. J. Lack of usefulness of prolonged bleeding times in predicting hemorrhagic events in patients receiving the 7e3 glycoprotein iib/iiia platelet antibody American Journal of Cardiology  1993 72:1121-1125  DOI:10.1016/0002-9149(93)90979-m  PMID:8237799
  • Hampton, J., Wilcox, R., Armstrong, P., Aylward, P., Bett, N., Charbonnier, B., Gulba, D., Heikkila, J., Jensen, G., Lopezbescos, L., Moulopoulos, S., Seabragomes, R., et al. Late assessment of thrombolytic efficacy (late) study with alteplase 6-24 hours after onset of acute myocardial-infarction Lancet  1993 342:759-766  PMID:8103874
  • Chapman, G. D., Ohman, M., Topol, E. J., Candela, R. J., Kereiakes, D. J., Samaha, J., Berrios, E., Pieper, K. S., Young, S. Y., Califf, R. M. Minimizing the risk of inappropriately administering thrombolytic therapy (thrombolysis and angioplasty in myocardial-infarction tami study-group) American Journal of Cardiology  1993 71:783-787  DOI:10.1016/0002-9149(93)90824-v  PMID:8456754
  • George, B. S., Voorhees, W. D., Roubin, G. S., Fearnot, N. E., Pinkerton, C. A., Raizner, A. E., King, S. B., Holmes, D. R., Topol, E. J., Kereiakes, D. J., Hartzler, G. O. Multicenter investigation of coronary stenting to treat acute or threatened closure after percutaneous transluminal coronary angioplasty - clinical and angiographic outcomes Journal of the American College of Cardiology  1993 22:135-143  PMID:8509533
  • Ohman, E. M., Christenson, R. H., Califf, R. M., George, B. S., Samaha, J. K., Kereiakes, D. J., Worley, S. J., Wall, T. C., Berrios, E., Sigmon, K. N., Lee, K., Topol, E. J. Noninvasive detection of reperfusion after thrombolysis based on serum creatine-kinase mb changes and clinical-variables American Heart Journal  1993 126:819-826  DOI:10.1016/0002-8703(93)90694-5  PMID:8213437
  • Granger, C. B., Califf, R. M., Young, S., Candela, R., Samaha, J., Worley, S., Kereiakes, D. J., Topol, E. J. Outcome of patients with diabetes-mellitus and acute myocardial-infarction treated with thrombolytic agents Journal of the American College of Cardiology  1993 21:920-925  PMID:8450161
  • Popma, J. J., Decesare, N. B., Pinkerton, C. A., Kereiakes, D. J., Whitlow, P., King, S. B., Topol, E. J., Holmes, D. R., Leon, M. B., Ellis, S. G. Quantitative-analysis of factors influencing late lumen loss and restenosis after directional coronary atherectomy American Journal of Cardiology  1993 71:552-557  DOI:10.1016/0002-9149(93)90510-j  PMID:8438740
  • Baim, D. S., Hinohara, T., Holmes, D., Topol, E., Pinkerton, C., King, S. B., Whitlow, P., Kereiakes, D., Farley, B., Simpson, J. B. Results of directional coronary atherectomy during multicenter preapproval testing American Journal of Cardiology  1993 72:6E-11E  DOI:10.1016/0002-9149(93)91032-d  PMID:8213572
  • Ellis, S. G., Tcheng, J. E., Navetta, F. I., Muller, D. W. M., Weisman, H. F., Smith, C., Anderson, K. M., Califf, R. M., Topol, E. J. Safety and antiplatelet effect of murine monoclonal-antibody 7e3 fab directed against platelet glycoprotein-iib/iiia in patients undergoing elective coronary angioplasty Coronary Artery Disease  1993 4:167-175  DOI:10.1097/00019501-199302000-00007  PMID:8269208
  • Brown, D. L., Topol, E. J. Stroke complicating percutaneous coronary revascularization American Journal of Cardiology  1993 72:1207-1209  DOI:10.1016/0002-9149(93)90998-r  PMID:8237818
  • Harrison, J. K., Califf, R. M., Woodlief, L. H., Kereiakes, D., George, B. S., Stack, R. S., Ellis, S. G., Lee, K. L., Oneill, W., Topol, E. J. Systolic left-ventricular function after reperfusion therapy for acute myocardial-infarction - an analysis of determinants of improvement Circulation  1993 87:1531-1541  PMID:8491008
  • Ross, A. M., Simoons, M. L., Lundergan, C., Thompson, M., Reiner, J., Deychak, Y., Rohrbeck, S., Coyne, K., Walker, P., Cho, S., Greenhouse, S., Lee, K., et al. The effects of tissue-plasminogen activator, streptokinase, or both on coronary-artery patency, ventricular-function, and survival after acute myocardial-infarction New England Journal of Medicine  1993 329:1615-1622  PMID:8232430
  • Lincoff, A. M., Califf, R. M., Ellis, S. G., Sigmon, K. N., Lee, K. L., Leimberger, J. D., Topol, E. J. Thrombolytic therapy for women with myocardial-infarction - is there a gender-gap Journal of the American College of Cardiology  1993 22:1780-1787  PMID:8245328
  • Nath, F. C., Muller, D. W. M., Ellis, S. G., Rosenschein, U., Chapekis, A., Quain, L., Zimmerman, C., Topol, E. J. Thrombosis of a flexible coil coronary stent - frequency, predictors and clinical outcome Journal of the American College of Cardiology  1993 21:622-627  PMID:8436743
  • Macisaac, A. I., Thomas, J. D., Topol, E. J. Toward the quiescent coronary plaque Journal of the American College of Cardiology  1993 22:1228-1241  PMID:8104965
  • Topol, E. J., Bonan, R., Jewitt, D., Sigwart, U., Kakkar, V. V., Rothman, M., Debono, D., Ferguson, J., Willerson, J. T., Strony, J., Ganz, P., Cohen, M. D., et al. Use of a direct antithrombin, hirulog, in place of heparin during coronary angioplasty Circulation  1993 87:1622-1629  PMID:8491018
  • Kalff, V., Hicks, R. J., Hutchins, G., Topol, E., Schwaiger, M. Use of c-11 acetate and dynamic positron emission tomography to assess regional myocardial oxygen-consumption in patients with acute myocardial-infarction receiving thrombolysis or coronary angioplasty American Journal of Cardiology  1993 71:529-535  DOI:10.1016/0002-9149(93)90507-9  PMID:8438738
  • Topol, E. J. Validation of the early open infarct vessel hypothesis American Journal of Cardiology  1993 72:G40-G45  DOI:10.1016/0002-9149(93)90106-m
  • Topol, E. J., Califf, R. M., Vandormael, M., Grines, C. L., George, B. S., Sanz, M. L., Wall, T., Obrien, M., Schwaiger, M., Aguirre, F. V., Young, S., Popma, J. J., et al. A randomized trial of late reperfusion therapy for acute myocardial infarction Circulation  1992 85:2090-2099  PMID:1591828
  • Popma, J. J., Topol, E. J., Hinohara, T., Pinkerton, C. A., Baim, D. S., King, S. B., Holmes, D. R., Whitlow, P. L., Kereiakes, D. J., Hartzler, G. O., Kent, K. M., Ellis, S. G., et al. Abrupt vessel closure after directional coronary atherectomy Journal of the American College of Cardiology  1992 19:1372-1379  PMID:1593028
  • Lincofe, A. M., Popma, J. J., Ellis, S. G., Hacker, J. A., Topol, E. J. Abrupt vessel closure complicating coronary angioplasty - clinical, angiographic and therapeutic profile Journal of the American College of Cardiology  1992 19:926-935  PMID:1552113
  • Wall, T. C., Califf, R. M., George, B. S., Ellis, S. G., Samaha, J. K., Kereiakes, D. J., Worley, S. J., Sigmon, K., Topol, E. J. Accelerated plasminogen-activator dose regimens for coronary thrombolysis Journal of the American College of Cardiology  1992 19:482-489  PMID:1537998
  • Arnold, A. Z., Topol, E. J. Assessment of reperfusion after thrombolytic therapy for myocardial-infarction American Heart Journal  1992 124:441-447  DOI:10.1016/0002-8703(92)90611-x  PMID:1636587
  • Gacioch, G. M., Ellis, S. G., Lee, L., Bates, E. R., Kirsh, M., Walton, J. A., Topol, E. J. Cardiogenic-shock complicating acute myocardial-infarction - the use of coronary angioplasty and the integration of the new support devices into patient-management Journal of the American College of Cardiology  1992 19:647-653  PMID:1538023
  • Decesare, N. B., Popma, J. J., Holmes, D. R., Dick, R. J., Whitlow, P. L., King, S. B., Pinkerton, C. A., Kereiakes, D. J., Topol, E. J., Haudenschild, C. C., Ellis, S. G. Clinical angiographic and histologic correlates of ectasia after directional coronary atherectomy American Journal of Cardiology  1992 69:314-319  DOI:10.1016/0002-9149(92)90226-o  PMID:1734641
  • Topol, E. J., Armstrong, P., Vandewerf, F., Kleiman, N., Lee, K., Morris, D., Simoons, M., Barbash, G., White, H., Califf, R. M. Confronting the issues of patient safety and investigator conflict-of-interest in an international clinical-trial of myocardial reperfusion Journal of the American College of Cardiology  1992 19:1123-1128  PMID:1564212
  • Grambow, D. W., Topol, E. J. Effect of maximal medical therapy on refractoriness of unstable angina-pectoris American Journal of Cardiology  1992 70:577-581  DOI:10.1016/0002-9149(92)90194-4  PMID:1354937
  • Muller, D. W. M., Ellis, S. G., Topol, E. J. Experimental-models of coronary-artery restenosis Journal of the American College of Cardiology  1992 19:418-432  PMID:1732371
  • Rosenschein, U., Ellis, S. G., Yakubov, S. J., Haudenschild, C. C., Dick, R. J., Topol, E. J. Histopathologic correlates of coronary lesion angiographic morphology - lessons from a directional atherectomy experience Coronary Artery Disease  1992 3:953-961
  • Muller, D. W. M., Topol, E. J., Abrams, G. D., Gallagher, K. P., Ellis, S. G. Intramural methotrexate therapy for the prevention of neointimal thickening after balloon angioplasty Journal of the American College of Cardiology  1992 20:460-466  PMID:1386089
  • Sutton, J. M., Topol, E. J. Left ventricular function assessment and acute myocardial infarction Current Opinion in Cardiology  1992 7:1035-1045  DOI:10.1097/00001573-199212000-00016
  • Popma, J. J., Califf, R. M., Ellis, S. G., George, B. S., Kereiakes, D. J., Samaha, J. K., Worley, S. J., Anderson, J. L., Stump, D., Woodlief, L., Sigmon, K., Wall, T. C., et al. Mechanism of benefit of combination thrombolytic therapy for acute myocardial-infarction - a quantitative angiographic and hematologic study Journal of the American College of Cardiology  1992 20:1305-1312  PMID:1430679
  • Muller, D. W. M., Shamir, K. J., Ellis, S. G., Topol, E. J. Peripheral vascular complications after conventional and complex percutaneous coronary interventional procedures American Journal of Cardiology  1992 69:63-68  DOI:10.1016/0002-9149(92)90677-q  PMID:1729869
  • Ellis, S. G., Mooney, M. R., George, B. S., Dasilva, E. E. R., Talley, J. D., Flanagan, W. H., Topol, E. J., Griffin, B., Samaha, J., Sawicki, E., Mooney, J., Chapekis, A. T., et al. Randomized trial of late elective angioplasty versus conservative management for patients with residual stenoses after thrombolytic treatment of myocardial-infarction Circulation  1992 86:1400-1406  PMID:1423952
  • Ellis, S. G., Savage, M., Fischman, D., Baim, D. S., Leon, M., Goldberg, S., Hirshfeld, J. W., Cleman, M. W., Teirstein, P. S., Walker, C., Bailey, S., Buchbinder, M., et al. Restenosis after placement of palmaz-schatz stents in native coronary-arteries - initial results of a multicenter experience Circulation  1992 86:1836-1844  PMID:1451256
  • Rosenschein, U., Yakubov, S. J., Guberinich, D., Bach, D. S., Sonda, P. L., Abrams, G. D., Topol, E. J. Shock-wave thrombus ablation, a new method for noninvasive mechanical thrombolysis American Journal of Cardiology  1992 70:1358-1361  DOI:10.1016/0002-9149(92)90775-t  PMID:1442591
  • Williamson, B. D., Muller, D. W. M., Topol, E. J. Should older patients with acute myocardial-infarction receive thrombolytic therapy Drugs & Aging  1992 2:461-468  PMID:1493350
  • Schwartz, R. S., Holmes, D. R., Topol, E. J. The restenosis paradigm revisited - an alternative proposal for cellular mechanisms Journal of the American College of Cardiology  1992 20:1284-1293  PMID:1401633
  • Muller, D. W. M., Topol, E. J. Thrombolytic therapy - adjuvant mechanical intervention for acute myocardial-infarction American Journal of Cardiology  1992 69:A60-A70  DOI:10.1016/0002-9149(92)91172-z
  • Granger, C. B., Califf, R. M., Topol, E. J. Thrombolytic therapy for acute myocardial-infarction - a review Drugs  1992 44:293-325  DOI:10.2165/00003495-199244030-00002  PMID:1382931
  • Doorey, A. J., Michelson, E. L., Topol, E. J. Thrombolytic therapy of acute myocardial-infarction - keeping the unfulfilled promises JAMA-Journal of the American Medical Association  1992 268:3108-3114  DOI:10.1001/jama.268.21.3108  PMID:1433742
  • Lee, P. N. V., Muller, D. W. M., Popma, J. J., Ellis, S. G., Topol, E. J. A comparison of clinical and quantitative angiographic outcomes of coronary stenting in elective and emergency settings: a single center experience Coronary Artery Disease  1991 2:945-951
  • Nabel, E. G., Topol, E. J., Galeana, A., Ellis, S. G., Bates, E. R., Werns, S. W., Walton, J. A., Muller, D. W., Schwaiger, M., Pitt, B. A randomized placebo-controlled trial of combined early intravenous captopril and recombinant tissue-type plasminogen-activator therapy in acute myocardial-infarction Journal of the American College of Cardiology  1991 17:467-473  PMID:1825097
  • Popma, J. J., Topol, E. J. Adjuncts to thrombolysis for myocardial reperfusion Annals of Internal Medicine  1991 115:34-44  PMID:1675557
  • Popma, J. J., Dick, R. J. L., Haudenschild, C. C., Topol, E. J., Ellis, S. G. Atherectomy of right coronary ostial stenoses - initial and long-term results, technical features and histologic-findings American Journal of Cardiology  1991 67:431-434  DOI:10.1016/0002-9149(91)90057-r  PMID:1994670
  • Ellis, S. G., Myler, R. K., King, S. B., Douglas, J. S., Topol, E. J., Shaw, R. E., Stertzer, S. H., Roubin, G. S., Murphy, M. C. Causes and correlates of death after unsupported coronary angioplasty - implications for use of angioplasty and advanced support techniques in high-risk settings American Journal of Cardiology  1991 68:1447-1451  DOI:10.1016/0002-9149(91)90277-r  PMID:1746425
  • Popma, J. J., Decesare, N. B., Ellis, S. G., Holmes, D. R., Pinkerton, C. A., Whitlow, P., King, S. B., Ghazzal, Z. M. B., Topol, E. J., Garratt, K. N., Kereiakes, D. J. Clinical, angiographic and procedural correlates of quantitative coronary dimensions after directional coronary atherectomy Journal of the American College of Cardiology  1991 18:1183-1189  PMID:1918694
  • Schatz, R. A., Goldberg, S., Leon, M., Baim, D., Hirshfeld, J., Cleman, M., Ellis, S., Topol, E. Clinical-experience with the palmaz-schatz coronary stent Journal of the American College of Cardiology  1991 17:B155-B159
  • Schatz, R. A., Baim, D. S., Leon, M., Ellis, S. G., Goldberg, S., Hirshfeld, J. W., Cleman, M. W., Cabin, H. S., Walker, C., Stagg, J., Buchbinder, M., Teirstein, P. S., et al. Clinical-experience with the palmaz-schatz coronary stent - initial results of a multicenter study Circulation  1991 83:148-161  PMID:1984878
  • Kirshenbaum, J. M., Bahr, R. D., Flaherty, J. T., Gurewich, V., Levine, H. J., Loscalzo, J., Schumacher, R. R., Topol, E. J., Wahr, D. W., Braunwald, E. Clot-selective coronary thrombolysis with low-dose synergistic combinations of single-chain urokinase-type plasminogen-activator and recombinant tissue-type plasminogen-activator American Journal of Cardiology  1991 68:1564-1569  DOI:10.1016/0002-9149(91)90310-h  PMID:1746455
  • Muller, D. W. M., Ellis, S. G., Topol, E. J. Colchicine and antineoplastic therapy for the prevention of restenosis after percutaneous coronary interventions Journal of the American College of Cardiology  1991 17:B126-B131
  • Morris, J. A., Muller, D. W. M., Topol, E. J. Combination thrombolytic therapy - a comparison of simultaneous and sequential regimens of tissue plasminogen-activator and urokinase American Heart Journal  1991 122:375-380  DOI:10.1016/0002-8703(91)90988-t  PMID:1907086
  • Clemmensen, P., Bates, E. R., Califf, R. M., Hlatky, M. A., Aronson, L., George, B. S., Lee, K. L., Kereiakes, D. J., Gacioch, G., Berrios, E., Topol, E. J. Complete atrioventricular-block complicating inferior wall acute myocardial-infarction treated with reperfusion therapy American Journal of Cardiology  1991 67:225-230  DOI:10.1016/0002-9149(91)90550-5  PMID:1899319
  • Topol, E. J., Holmes, D. R., Rogers, W. J. Coronary angiography after thrombolytic therapy for acute myocardial-infarction Annals of Internal Medicine  1991 114:877-885  PMID:2014950
  • Kereiakes, D. J., Califf, R. M., George, B. S., Ellis, S., Samaha, J., Stack, R., Martin, L. H., Young, S., Topol, E. J. Coronary-bypass surgery improves global and regional left-ventricular function following thrombolytic therapy for acute myocardial-infarction American Heart Journal  1991 122:390-399  DOI:10.1016/0002-8703(91)90991-p  PMID:1907087
  • Sane, D. C., Stump, D. C., Topol, E. J., Sigmon, K. N., Kereiakes, D. J., George, B. S., Mantell, S. J., Macy, E., Collen, D., Califf, R. M. Correlation between base-line plasminogen-activator inhibitor levels and clinical outcome during therapy with tissue plasminogen-activator for acute myocardial-infarction Thrombosis and Haemostasis  1991 65:275-279  PMID:1904653
  • Ellis, S. G., Cowley, M. J., Disciascio, G., Deligonul, U., Topol, E. J., Bulle, T. M., Vandormael, M. G. Determinants of 2-year outcome after coronary angioplasty in patients with multivessel disease on the basis of comprehensive preprocedural evaluation - implications for patient selection Circulation  1991 83:1905-1914  PMID:2040043
  • Muller, D. W. M., Topol, E. J., Ellis, S. G., Woodlief, L. H., Sigmon, K. N., Kereiakes, D. J., George, B. S., Worley, S. J., Samaha, J. K., Phillips, H., Califf, R. M. Determinants of the need for early acute intervention in patients treated conservatively after thrombolytic therapy for acute myocardial-infarction Journal of the American College of Cardiology  1991 18:1594-1601  PMID:1960302
  • Dick, R. J. L., Haudenschild, C. C., Popma, J. J., Ellis, S. G., Muller, D. W., Topol, E. J. Directional atherectomy for total coronary occlusions Coronary Artery Disease  1991 2:189-199  DOI:10.1097/00019501-199104000-00010
  • Dellborg, M., Topol, E. J., Swedberg, K. Dynamic qrs complex and st segment vectorcardiographic monitoring can identify vessel patency in patients with acute myocardial-infarction treated with reperfusion therapy American Heart Journal  1991 122:943-948  DOI:10.1016/0002-8703(91)90455-q  PMID:1927880
  • Califf, R. M., Topol, E. J., Stack, R. S., Ellis, S. G., George, B. S., Kereiakes, D. J., Samaha, J. K., Worley, S. J., Anderson, J. L., Harrelson-Woodlief, S. L., Wall, T. C., Phillips, H. R., et al. Evaluation of combination thrombolytic therapy and timing of cardiac-catheterization in acute myocardial-infarction - results of thrombolysis and angioplasty in myocardial-infarction phase-5 randomized trial Circulation  1991 83:1543-1556  PMID:1902405
  • Mark, D. B., Sigmon, K., Topol, E. J., Kereiakes, D. J., Pryor, D. B., Candela, R. J., Califf, R. M. Identification of acute myocardial-infarction patients suitable for early hospital discharge after aggressive interventional therapy - results from the thrombolysis and angioplasty in acute myocardial-infarction registry Circulation  1991 83:1186-1193  PMID:2013140
  • Muller, D. W. M., Topol, E. J. Implantable devices in the coronary-artery - from metal to genes Trends in Cardiovascular Medicine  1991 1:225-232  DOI:10.1016/1050-1738(91)90026-b  PMID:21239300
  • Dick, R. J., Popma, J. J., Muller, D. W. M., Burek, K. A., Topol, E. J. In-hospital costs associated with new percutaneous coronary devices American Journal of Cardiology  1991 68:879-885  DOI:10.1016/0002-9149(91)90403-8  PMID:1927947
  • Topol, E. J. Integration of anticoagulation, thrombolysis and coronary angioplasty for unstable angina-pectoris American Journal of Cardiology  1991 68:B136-B141  DOI:10.1016/0002-9149(91)90396-3
  • Bates, E. R., Topol, E. J. Limitations of thrombolytic therapy for acute myocardial-infarction complicated by congestive-heart-failure and cardiogenic-shock Journal of the American College of Cardiology  1991 18:1077-1084  PMID:1894853
  • Muller, D. W. M., Topol, E. J., Ellis, S. G., Sigmon, K. N., Lee, K., Califf, R. M. Multivessel coronary-artery disease - a key predictor of short-term prognosis after reperfusion therapy for acute myocardial-infarction American Heart Journal  1991 121:1042-1049  DOI:10.1016/0002-8703(91)90661-z  PMID:1901190
  • Kereiakes, D. J., Topol, E. J., George, B. S., Stack, R. S., Abbottsmith, C. W., Ellis, S., Candela, R. J., Harrelson, L., Martin, L. H., Califf, R. M. Myocardial-infarction with minimal coronary atherosclerosis in the era of thrombolytic reperfusion Journal of the American College of Cardiology  1991 17:304-312  PMID:1899433
  • Lincoff, A. M., Popma, J. J., Ellis, S. G., Vogel, R. A., Topol, E. J. Percutaneous support devices for high-risk or complicated coronary angioplasty Journal of the American College of Cardiology  1991 17:770-780  PMID:1993799
  • Ellis, S. G., Bates, E. R., Schaible, T., Weisman, H. F., Pitt, B., Topol, E. J. Prospects for the use of antagonists to the platelet glycoprotein-IIb glycoprotein-IIIa receptor to prevent postangioplasty restenosis and thrombosis Journal of the American College of Cardiology  1991 17:B89-B95
  • Sane, D. C., Stump, D. C., Topol, E. J., Sigmon, K. N., Clair, W. K., Kereiakes, D. J., George, B. S., Stoddard, M. F., Bates, E. R., Stack, R. S., Califf, R. M. Racial-differences in responses to thrombolytic therapy with recombinant tissue-type plasminogen-activator - increased fibrin(ogen)olysis in blacks Circulation  1991 83:170-175  PMID:1898641
  • Ellis, S. G., Decesare, N. B., Pinkerton, C. A., Whitlow, P., King, S. B., Ghazzal, Z. M. B., Kereiakes, D. J., Popma, J. J., Menke, K. K., Topol, E. J., Holmes, D. R. Relation of stenosis morphology and clinical presentation to the procedural results of directional coronary atherectomy Circulation  1991 84:644-653  PMID:1860208
  • Sutton, J. M., Topol, E. J. Significance of a negative exercise thallium test in the presence of a critical residual stenosis after thrombolysis for acute myocardial-infarction Circulation  1991 83:1278-1286  PMID:1901529
  • Topol, E. J., Agnelli, G. Strategies for administration of tissue plasminogen-activator Molecular Biology & Medicine  1991 8:219-234  PMID:1806764
  • Stewart, R. E., Kander, N., Juni, J. E., Ellis, S. G., Oneill, W. W., Schork, A., Topol, E. J., Schwaiger, M. Submaximal exercise tl-201 spect for assessment of interventional therapy in patients with acute myocardial-infarction American Heart Journal  1991 121:1033-1041  DOI:10.1016/0002-8703(91)90660-a  PMID:1901189
  • Ohman, E. M., Califf, R. M., George, B. S., Quigley, P. J., Kereiakes, D. J., Harrelson-Woodlief, S. L., Candela, R. J., Flanagan, C., Stack, R. S., Topol, E. J. The use of intraaortic balloon pumping as an adjunct to reperfusion therapy in acute myocardial-infarction American Heart Journal  1991 121:895-901  DOI:10.1016/0002-8703(91)90205-v  PMID:1900381
  • Tenaglia, A. N., Califf, R. M., Candela, R. J., Kereiakes, D. J., Berrios, E., Young, S. Y., Stack, R. S., Topol, E. J. Thrombolytic therapy in patients requiring cardiopulmonary-resuscitation American Journal of Cardiology  1991 68:1015-1019  DOI:10.1016/0002-9149(91)90488-7  PMID:1927913
  • Ellis, S. G., Debowey, D., Bates, E. R., Topol, E. J. Treatment of recurrent ischemia after thrombolysis and successful reperfusion for acute myocardial-infarction - effect on in-hospital mortality and left-ventricular function Journal of the American College of Cardiology  1991 17:752-757  PMID:1993797
  • Topol, E. J. Which thrombolytic agent should one choose Progress in Cardiovascular Diseases  1991 34:165-178  DOI:10.1016/0033-0620(91)90011-a  PMID:1947122
  • Muller, D. W. M., Topol, E. J., George, B. S., Kereiakes, D. J., Aronson, L. G., Lee, K. L., Abbottsmith, C. W., Ellis, S. G., Califf, R. M. 2-year outcome after angiographically documented myocardial reperfusion for acute coronary-occlusion American Journal of Cardiology  1990 66:796-801  DOI:10.1016/0002-9149(90)90354-4  PMID:2220575
  • Kander, N. H., Holland, K. J., Pitt, B., Topol, E. J. A randomized pilot trial of brief versus prolonged heparin after successful reperfusion in acute myocardial-infarction American Journal of Cardiology  1990 65:139-142  DOI:10.1016/0002-9149(90)90074-b  PMID:2404389
  • Popma, J. J., Topol, E. J. Accelerated, combined, and adjunctive thrombolytic strategies for acute myocardial-infarction Current Opinion in Cardiology  1990 5:482-489  DOI:10.1097/00001573-199008000-00017
  • Kavanaugh, K. M., Topol, E. J. Acute intervention during myocardial-infarction in patients with prior coronary-bypass surgery American Journal of Cardiology  1990 65:924-926  DOI:10.1016/0002-9149(90)91440-h  PMID:2321545
  • George, B. S., Candela, R. J., Topol, E. J., Stack, R. S., Kereiakes, D. J., Abbottsmith, C. W., Masek, R., Pickel, A., Dillon, J., Harrelson, L., Califf, R. M. Brachial approach to emergency cardiac-catheterization during thrombolytic therapy for acute myocardial-infarction Catheterization and Cardiovascular Diagnosis  1990 20:221-226  DOI:10.1002/ccd.1810200402  PMID:2119888
  • Topol, E. J. Can thrombolysis be improved? Hospital Formulary  1990 25:19-22
  • Ohman, E. M., Califf, R. M., Topol, E. J., Candela, R., Abbottsmith, C., Ellis, S., Sigmon, K. N., Kereiakes, D., George, B., Stack, R. Consequences of reocclusion after successful reperfusion therapy in acute myocardial-infarction Circulation  1990 82:781-791  PMID:2394002
  • Topol, E. J. Coronary angioplasty in myocardial infarction Hospital Practice  1990 25:73-76, 79  PMID:2109756
  • Samson, M., Sutton, J. M., Topol, E. J., Serruys, P. W. Coronary angioplasty in myocardial-infarction - where are we Annales de Cardiologie et d'Angéiologie  1990 39:371-377  PMID:2205155
  • Ellis, S. G., Vandormael, M. G., Cowley, M. J., Disciascio, G., Deligonul, U., Topol, E. J., Bulle, T. M. Coronary morphological and clinical determinants of procedural outcome with angioplasty for multivessel coronary-disease - implications for patient selection Circulation  1990 82:1193-1202  PMID:2401060
  • Popma, J. J., Topol, E. J. Factors influencing restenosis after coronary angioplasty American Journal of Medicine  1990 88:N16-N24
  • Abbottsmith, C. W., Topol, E. J., George, B. S., Stack, R. S., Kereiakes, D. J., Candela, R. J., Anderson, L. C., Harrelson-Woodlief, S. L. ,, Califf, R. M. Fate of patients with acute myocardial-infarction with patency of the infarct-related vessel achieved with successful thrombolysis versus rescue angioplasty Journal of the American College of Cardiology  1990 16:770-778  PMID:1698843
  • Vogel, R. A., Shawl, F., Tommaso, C., Oneill, W., Overlie, P., Otoole, J., Vandormael, M., Topol, E., Tabari, K. K., Vogel, J., Smith, S., Freedmann, R., et al. Initial report of the national-registry-of-elective-cardiopulmonary bypass supported coronary angioplasty Journal of the American College of Cardiology  1990 15:23-29  PMID:2404047
  • Williams, D. O., Topol, E. J., Califf, R. M., Roberts, R., Mancini, G. B. J., Joelson, J. M., Ellis, S. G., Kleiman, N. S. Intravenous recombinant tissue-type plasminogen-activator in patients with unstable angina-pectoris - results of a placebo-controlled, randomized trial Circulation  1990 82:376-383  PMID:2115407
  • Califf, R. M., Topol, E. J., George, B. S., Kereiakes, D. J., Aronson, L. G., Lee, K. L., Martin, L., Candela, R., Abbottsmith, C., Oneill, W. W., Pryor, D. B., Stack, R. S. One-year outcome after therapy with tissue plasminogen-activator - report from the thrombolysis and angioplasty in myocardial-infarction trial American Heart Journal  1990 119:777-785  DOI:10.1016/s0002-8703(05)80311-4  PMID:2108575
  • Topol, E. J., Wilson, V. E. Pivotal role of early and sustained infarct vessel patency in patients with acute myocardial-infarction Heart & Lung  1990 19:583-595  PMID:2228647
  • Ellis, S. G., Muller, D. W., Topol, E. J. Possible survival benefit from concomitant beta-antagonist but not calcium-antagonist therapy during reperfusion for acute myocardial-infarction American Journal of Cardiology  1990 66:125-128  DOI:10.1016/0002-9149(90)90574-k  PMID:1973588
  • Bates, E. R., Clemmensen, P. M., Califf, R. M., Gorman, L. E., Aronson, L. G., George, B. S., Kereiakes, D. J., Topol, E. J. Precordial st segment depression predicts a worse prognosis in inferior infarction despite reperfusion therapy Journal of the American College of Cardiology  1990 16:1538-1544  PMID:2123903
  • Muller, D. W. M., Ellis, S. G., Debowey, D. L., Topol, E. J. Quantitative angiographic comparison of the immediate success of coronary angioplasty, coronary atherectomy and endoluminal stenting American Journal of Cardiology  1990 66:938-942  DOI:10.1016/0002-9149(90)90929-u  PMID:2220616
  • Muller, D. W. M., Topol, E. J., Califf, R. M., Sigmon, K. N., Gorman, L., George, B. S., Kereiakes, D. J., Lee, K. L., Ellis, S. G. Relationship between antecedent angina-pectoris and short-term prognosis after thrombolytic therapy for acute myocardial-infarction American Heart Journal  1990 119:224-231  DOI:10.1016/s0002-8703(05)80008-0  PMID:2405608
  • Ellis, S. G., Topol, E. J. Results of percutaneous transluminal coronary angioplasty of high-risk angulated stenoses American Journal of Cardiology  1990 66:932-937  DOI:10.1016/0002-9149(90)90928-t  PMID:2220615
  • Muller, D. W. M., Topol, E. J. Selection of patients with acute myocardial-infarction for thrombolytic therapy Annals of Internal Medicine  1990 113:949-960  PMID:2240919
  • Oconnor, C. M., Califf, R. M., Massey, E. W., Mark, D. B., Kereiakes, D. J., Candela, R. J., Abbottsmith, C., George, B., Stack, R. S., Aronson, L., Mantell, S., Topol, E. J. Stroke and acute myocardial-infarction in the thrombolytic era - clinical correlates and long-term prognosis Journal of the American College of Cardiology  1990 16:533-540  PMID:2117618
  • Muller, D. W. M., Topol, E. J. Unresolved issues: late reperfusion, lytic failure, and reocclusion Coronary Artery Disease  1990 1:39-49  DOI:10.1097/00019501-199001000-00007
  • Wall, T. C., Califf, R. M., Harrelson-Woodlief, S. L. ,, Mark, D. B., Honan, M., Abbotsmith, C. W., Candela, R., Berrios, E., Phillips, H. R., Topol, E. J. Usefulness of a pericardial friction rub after thrombolytic therapy during acute myocardial-infarction in predicting amount of myocardial damage American Journal of Cardiology  1990 66:1418-1421  DOI:10.1016/0002-9149(90)90526-7  PMID:2123603
  • Sutton, J. M., Topol, E. J. Usefulness of coronary-artery angioplasty strategies in acute myocardial-infarction Canadian Journal of Cardiology  1990 6:111-122  PMID:2187576
  • Topol, E. J., George, B. S., Kereiakes, D. J., Stump, D. C., Candela, R. J., Abbottsmith, C. W., Aronson, L., Pickel, A., Boswick, J. M., Lee, K. L., Ellis, S. G., Califf, R. M. A randomized controlled trial of intravenous tissue plasminogen-activator and early intravenous heparin in acute myocardial-infarction Circulation  1989 79:281-286  PMID:2492454
  • Muller, D. W. M., Topol, E. J. Acute myocardial infarction: early and late percutaneous trans-luminal coronary angioplasty Current Opinion in Cardiology  1989 4:524-530  DOI:10.1097/00001573-198908000-00012
  • Muller, D. W. M., Ellis, S. G., Topol, E. J. Atherectomy of the left main coronary-artery with percutaneous cardiopulmonary bypass support American Journal of Cardiology  1989 64:114-116  DOI:10.1016/0002-9149(89)90668-1  PMID:2787097
  • Sane, D. C., Califf, R. M., Topol, E. J., Stump, D. C., Mark, D. B., Greenberg, C. S. Bleeding during thrombolytic therapy for acute myocardial-infarction - mechanisms and management Annals of Internal Medicine  1989 111:1010-1022  PMID:2688504
  • Loscalzo, J., Wharton, T. P., Kirshenbaum, J. M., Levine, H. J., Flaherty, J. T., Topol, E. J., Ramaswamy, K., Kosowsky, B. D., Salem, D. N., Ganz, P., Brinker, J. A., Gurewich, V., et al. Clot-selective coronary thrombolysis with pro-urokinase Circulation  1989 79:776-782  PMID:2494004
  • Topol, E. J., Ellis, S. G., Califf, R. M., George, B. S., Stump, D. C., Bates, E. R., Nabel, E. G., Walton, J. A., Candela, R. J., Lee, K. L., Kline, E. M., Pitt, B. Combined tissue-type plasminogen-activator and prostacyclin therapy for acute myocardial-infarction Journal of the American College of Cardiology  1989 14:877-884  PMID:2477426
  • Ellis, S. G., Oneill, W. W., Bates, E. R., Walton, J. A., Nabel, E. G., Topol, E. J. Coronary angioplasty as primary therapy for acute myocardial-infarction 6 to 48 hours after symptom onset - report of an initial experience Journal of the American College of Cardiology  1989 13:1122-1126  PMID:2522467
  • Bates, E. R., Topol, E. J. Early hospital discharge in the myocardial reperfusion era Clinical Cardiology  1989 12:65-70  PMID:2691143
  • Holland, K. J., Oneill, W. W., Bates, E. R., Pitt, B., Topol, E. J. Emergency percutaneous trans-luminal coronary angioplasty during acute myocardial-infarction for patients more than 70 years of age American Journal of Cardiology  1989 63:399-403  DOI:10.1016/0002-9149(89)90307-x  PMID:2521765
  • Burek, K. A., Kirscht, J., Topol, E. J. Exercise capacity in patients 3 days after acute, uncomplicated myocardial-infarction Heart & Lung  1989 18:575-582  PMID:2684916
  • Kereiakes, D. J., Topol, E. J., George, B. S., Abbottsmith, C. W., Stack, R. S., Candela, R. J., Oneill, W. W., Anderson, L. C., Califf, R. M. Favorable early and long-term prognosis following coronary-bypass surgery therapy for myocardial-infarction - results of a multicenter trial American Heart Journal  1989 118:199-207  DOI:10.1016/0002-8703(89)90177-4  PMID:2526573
  • Califf, R. M., Topol, E. J., Gersh, B. J. From myocardial salvage to patient salvage in acute myocardial-infarction - the role of reperfusion therapy Journal of the American College of Cardiology  1989 14:1382-1388  DOI:10.1016/0735-1097(89)90445-2  PMID:2681322
  • Ellis, S. G., Oneill, W. W., Bates, E. R., Walton, J. A., Nabel, E. G., Werns, S. W., Topol, E. J. Implications for patient triage from survival and left-ventricular functional recovery analyses in 500 patients treated with coronary angioplasty for acute myocardial-infarction Journal of the American College of Cardiology  1989 13:1251-1259  PMID:2522954
  • Ellis, S. G., Gallison, L., Grines, C. L., Langburd, A. B., Bates, E. R., Walton, J. A., Oneill, W. W., Topol, E. J. Incidence and predictors of early recurrent ischemia after successful percutaneous trans-luminal coronary angioplasty for acute myocardial-infarction American Journal of Cardiology  1989 63:263-268  DOI:10.1016/0002-9149(89)90327-5  PMID:2521536
  • Ellis, S. G., Topol, E. J. Intracoronary stents - will they fulfill their promise as an adjunct to angioplasty Journal of the American College of Cardiology  1989 13:1425-1430  PMID:2522960
  • Kander, N. H., Oneill, W., Topol, E. J., Gallison, L., Mileski, R., Ellis, S. G. Long-term follow-up of patients treated with coronary angioplasty for acute myocardial-infarction American Heart Journal  1989 118:228-233  DOI:10.1016/0002-8703(89)90180-4  PMID:2526574
  • Stump, D. C., Califf, R. M., Topol, E. J., Sigmon, K., Thornton, D., Masek, R., Anderson, L., Collen, D. Pharmacodynamics of thrombolysis with recombinant tissue-type plasminogen-activator - correlation with characteristics of and clinical outcomes in patients with acute myocardial-infarction Circulation  1989 80:1222-1230  PMID:2509104
  • Grines, C. L., Topol, E. J., Califf, R. M., Stack, R. S., George, B. S., Kereiakes, D., Boswick, J. M., Kline, E., Oneill, W. W. Prognostic implications and predictors of enhanced regional wall motion of the noninfarct zone after thrombolysis and angioplasty therapy of acute myocardial-infarction Circulation  1989 80:245-253  PMID:2526697
  • Nicklas, J. M., Topol, E. J., Kander, N., Oneill, W. W., Walton, J. A., Ellis, S. G., Gorman, L., Pitt, B. Randomized, double-blind, placebo-controlled trial of tissue plasminogen-activator in unstable angina Journal of the American College of Cardiology  1989 13:434-441  PMID:2492325
  • Topol, E. J. Recombinant tissue plasminogen-activator - implications in therapy Seminars in Hematology  1989 26:25-31
  • Ellis, S. G., Topol, E. J., George, B. S., Kereiakes, D. J., Debowey, D., Sigmon, K. N., Pickel, A., Lee, K. L., Califf, R. M. Recurrent ischemia without warning - analysis of risk-factors for in-hospital ischemic events following successful thrombolysis with intravenous tissue plasminogen-activator Circulation  1989 80:1159-1165  PMID:2509102
  • Holmes, D. R., Topol, E. J. Reperfusion momentum - lessons from the randomized trials of immediate coronary angioplasty for myocardial-infarction Journal of the American College of Cardiology  1989 14:1572-1578  DOI:10.1016/0735-1097(89)90401-4  PMID:2809019
  • Ellis, S. G., Shaw, R. E., King, S. B., Myler, R. K., Topol, E. J. Restenosis after excellent angiographic angioplasty result for chronic total coronary-artery occlusion - implications for newer percutaneous revascularization devices American Journal of Cardiology  1989 64:667-668  DOI:10.1016/0002-9149(89)90500-6  PMID:2528903
  • Ellis, S. G., Shaw, R. E., Gershony, G., Thomas, R., Roubin, G. S., Douglas, J. S., Topol, E. J., Startzer, S. H., Myler, R. K., King, S. B. Risk-factors, time course and treatment effect for restenosis after successful percutaneous trans-luminal coronary angioplasty of chronic total occlusion American Journal of Cardiology  1989 63:897-901  DOI:10.1016/0002-9149(89)90135-5  PMID:2522727
  • Gacioch, G. M., Topol, E. J. Sudden paradoxic clinical deterioration during angioplasty of the occluded right coronary-artery in acute myocardial-infarction Journal of the American College of Cardiology  1989 14:1202-1209  DOI:10.1016/0735-1097(89)90418-x  PMID:2808974
  • Chapekis, A. T., Burek, K., Topol, E. J. The cost-benefit ratio of acute intervention for myocardial-infarction - results of a prospective, matched pair analysis American Heart Journal  1989 118:878-882  DOI:10.1016/0002-8703(89)90217-2  PMID:2510487
  • Bates, E. R., Califf, R. M., Stack, R. S., Aronson, L., George, B. S., Candela, R. J., Kereiakes, D. J., Abbottsmith, C. W., Anderson, L., Pitt, B., Oneill, W. W., Topol, E. J. Thrombolysis and angioplasty in myocardial-infarction (tami-1) trial - influence of infarct location on arterial patency, left-ventricular function and mortality Journal of the American College of Cardiology  1989 13:12-18  PMID:2521226
  • Topol, E. J., Burek, K., Oneill, W. W., Kewman, D. G., Kander, N. H., Shea, M. J., Schork, M. A., Kirscht, J., Juni, J. E., Pitt, B. A randomized controlled trial of hospital discharge 3 days after myocardial-infarction in the era of reperfusion New England Journal of Medicine  1988 318:1083-1088  DOI:10.1056/nejm198804283181702  PMID:3281014
  • Topol, E. J. An overview of the thrombolysis and angioplasty in acute myocardial infarction (TAMI) trials Archives Des Maladies Du Coeur Et Des Vaisseaux  1988 81:45-49  PMID:2973302
  • Califf, R. M., Topol, E. J., George, B. S., Boswick, J. M., Lee, K. L., Stump, D., Dillon, J., Abbottsmith, C., Candela, R. J., Kereiakes, D. J., Oneill, W. W., Stack, R. S. Characteristics and outcome of patients in whom reperfusion with intravenous tissue-type plasminogen-activator fails - results of the thrombolysis and angioplasty in myocardial-infarction (tami) i-trial Circulation  1988 77:1090-1099  PMID:2966016
  • Topol, E. J., George, B. S., Kereiakes, D. J., Candela, R. J., Abbottsmith, C. W., Stump, D. C., Boswick, J. M., Stack, R. S., Califf, R. M. Comparison of 2 dose regimens of intravenous tissue plasminogen-activator for acute myocardial-infarction American Journal of Cardiology  1988 61:723-728  DOI:10.1016/0002-9149(88)91055-7  PMID:2965504
  • Grines, C. L., Oneill, W. W., Anselmo, E. G., Juni, J. E., Topol, E. J. Comparison of left-ventricular function and contractile reserve after successful recanalization by thrombolysis versus rescue percutaneous trans-luminal coronary angioplasty for acute myocardial-infarction American Journal of Cardiology  1988 62:352-357  DOI:10.1016/0002-9149(88)90957-5  PMID:2970774
  • Topol, E. J. Coronary angioplasty for acute myocardial-infarction Annals of Internal Medicine  1988 109:970-978  PMID:2973762
  • Topol, E. J., Califf, R. M., George, B. S., Kereiakes, D. J., Rothbaum, D., Candela, R. J., Abbotsmith, C. W., Pinkerton, C. A., Stump, D. C., Collen, D., Lee, K. L., Pitt, B., et al. Coronary arterial thrombolysis with combined infusion of recombinant tissue-type plasminogen-activator and urokinase in patients with acute myocardial-infarction Circulation  1988 77:1100-1107  PMID:2966017
  • Topol, E. J., Nicklas, J. M., Kander, N. H., Walton, J. A., Ellis, S. G., Gorman, L., Pitt, B. Coronary revascularization after intravenous tissue plasminogen-activator for unstable angina-pectoris - results of a randomized, double-blind, placebo-controlled trial American Journal of Cardiology  1988 62:368-371  DOI:10.1016/0002-9149(88)90960-5  PMID:2970776
  • Steinberg, E. P., Topol, E. J., Sakin, J. W., Kahane, S. N., Appel, L. J., Powe, N. R., Anderson, G. F., Erickson, J. E., Guerci, A. D. Cost and procedure implications of thrombolytic therapy for acute myocardial-infarction Journal of the American College of Cardiology  1988 12:A58-A68
  • Kereiakes, D. J., Topol, E. J., George, B. S., Abbottsmith, C. W., Stack, R. S., Candela, R. J., Oneill, W. W., Martin, L. H., Califf, R. M. Emergency coronary-artery bypass-surgery preserves global and regional left-ventricular function after intravenous tissue plasminogen-activator therapy for acute myocardial-infarction Journal of the American College of Cardiology  1988 11:899-907  PMID:2965716
  • Califf, R. M., Oneil, W., Stack, R. S., Aronson, L., Mark, D. B., Mantell, S., George, B. S., Candela, R. J., Kereiakes, D. J., Abbottsmith, C., Topol, E. J. Failure of simple clinical measurements to predict perfusion status after intravenous thrombolysis Annals of Internal Medicine  1988 108:658-662  PMID:3128953
  • Califf, R. M., Topol, E. J., George, B. S., Boswick, J. M., Abbottsmith, C., Sigmon, K. N., Candela, R., Masek, R., Kereiakes, D., Oneill, W. W., Stack, R. S., Stump, D. Hemorrhagic complications associated with the use of intravenous tissue plasminogen-activator in treatment of acute myocardial-infarction American Journal of Medicine  1988 85:353-359  DOI:10.1016/0002-9343(88)90586-4  PMID:3137818
  • Humphrey, L. S., Topol, E. J., Rosenfeld, G. I., Borkon, A. M., Baumgartner, W. A., Gardner, T. J., Maruschak, G., Weiss, J. L. Immediate enhancement of left-ventricular relaxation by coronary-artery bypass-grafting - intraoperative assessment Circulation  1988 77:886-896  PMID:3258195
  • Grines, C. L., Topol, E. J., Bates, E. R., Juni, J. E., Walton, J. A., Oneill, W. W. Infarct vessel status after intravenous tissue plasminogen-activator and acute coronary angioplasty - prediction of clinical outcome American Heart Journal  1988 115:1-7  DOI:10.1016/0002-8703(88)90510-8  PMID:2962478
  • Topol, E. J., Califf, R. M., George, B. S., Kereiakes, D. J., Lee, K. L. Insights derived from the thrombolysis and angioplasty in myocardial-infarction (tami) trials Journal of the American College of Cardiology  1988 12:A24-A31
  • Carlson, S. E., Aldrich, M. S., Greenberg, H. S., Topol, E. J. Intracerebral hemorrhage complicating intravenous tissue plasminogen-activator treatment Archives of Neurology  1988 45:1070-1073  PMID:3140769
  • Stump, D. C., Topol, E. J., Chen, A. B., Hopkins, A., Collen, D. Monitoring of hemostasis parameters during coronary thrombolysis with recombinant tissue-type plasminogen-activator Thrombosis and Haemostasis  1988 59:133-137  PMID:2455358
  • Ellis, S. G., Topol, E. J., Gallison, L., Grines, C. L., Langburd, A. B., Bates, E. R., Walton, J. A., Oneill, W. W. Predictors of success for coronary angioplasty performed for acute myocardial-infarction Journal of the American College of Cardiology  1988 12:1407-1415  PMID:2973481
  • Oneill, W. W., Topol, E. J., Pitt, B. Reperfusion therapy of acute myocardial-infarction Progress in Cardiovascular Diseases  1988 30:235-266  DOI:10.1016/0033-0620(88)90018-7  PMID:3275989
  • Topol, E. J., Morris, D. C., Smalling, R. W., Schumacher, R. R., Taylor, C. R., Nishikawa, A., Liberman, H. A., Collen, D., Tufte, M. E., Grossbard, E. B., Oneill, W. W. A multicenter, randomized, placebo-controlled trial of a new form of intravenous recombinant tissue-type plasminogen-activator (activase) in acute myocardial-infarction Journal of the American College of Cardiology  1987 9:1205-1213  PMID:2953770
  • Topol, E. J., Califf, R. M., George, B. S., Kereiakes, D. J., Abbottsmith, C. W., Candela, R. J., Lee, K. L., Pitt, B., Stack, R. S., Oneill, W. W. A randomized trial of immediate versus delayed elective angioplasty after intravenous tissue plasminogen-activator in acute myocardial-infarction New England Journal of Medicine  1987 317:581-588  DOI:10.1056/nejm198709033171001  PMID:2956516
  • Guerci, A. D., Gerstenblith, G., Brinker, J. A., Chandra, N. C., Gottlieb, S. O., Bahr, R. D., Weiss, J. L., Shapiro, E. P., Flaherty, J. T., Bush, D. E., Chew, P. H., Gottlieb, S. H., et al. A randomized trial of intravenous tissue plasminogen-activator for acute myocardial-infarction with subsequent randomization to elective coronary angioplasty New England Journal of Medicine  1987 317:1613-1618  DOI:10.1056/nejm198712243172601  PMID:2960897
  • Topol, E. J., Oneill, W. W., Langburd, A. B., Walton, J. A., Bourdillon, P. D. V., Bates, E. R., Grines, C. L., Schork, A. M., Kline, E., Pitt, B. A randomized, placebo-controlled trial of intravenous recombinant tissue-type plasminogen-activator and emergency coronary angioplasty in patients with acute myocardial-infarction Circulation  1987 75:420-428  PMID:2948735
  • Topol, E. J. Acute intervention for myocardial-infarction Chest  1987 92:929-932  DOI:10.1378/chest.92.5.929  PMID:2959455
  • Topol, E. J. Advances in thrombolytic therapy for acute myocardial-infarction Journal of Clinical Pharmacology  1987 27:735-745  PMID:3123526
  • Topol, E. J. Clinical use of streptokinase and urokinase therapy for acute myocardial-infarction Heart & Lung  1987 16:760-774  PMID:3316129
  • Topol, E. J., Bates, E. R., Walton, J. A., Baumann, G., Wolfe, S., Maino, J., Bayer, L., Gorman, L., Kline, E. M., Oneill, W. W., Pitt, B. Community-hospital administration of intravenous tissue plasminogen-activator in acute myocardial-infarction - improved timing, thrombolytic efficacy and ventricular-function Journal of the American College of Cardiology  1987 10:1173-1177  PMID:3119685
  • Oneill, W. W., Topol, E. J., Fung, A., Bourdillon, P. D. V., Nicklas, J. M., Walton, J., Bates, E. R., Pitt, B. Coronary angioplasty as therapy for acute myocardial infarction: University of Michigan experience Circulation  1987 76:79-87  PMID:2955959
  • Bates, E. R., Topol, E. J., Kline, E. M., Langburd, A. B., Fung, A. Y., Walton, J. A., Bourdillon, P. D. V., Vogel, R. A., Pitt, B., Oneill, W. W. Early reperfusion therapy improves left-ventricular function after acute inferior myocardial-infarction associated with right coronary-artery disease American Heart Journal  1987 114:261-267  DOI:10.1016/0002-8703(87)90488-1  PMID:2955688
  • Topol, E. J., Juni, J. E., Oneill, W. W., Nicklas, J. M., Shea, M. J., Burek, K., Pitt, B. Exercise testing 3 days after onset of acute myocardial-infarction American Journal of Cardiology  1987 60:958-962  DOI:10.1016/0002-9149(87)90332-8  PMID:2960230
  • Topol, E. J., Ellis, S. G., Fishman, J., Leimgruber, P., Myler, R. K., Stertzer, S. H., Oneill, W. W., Douglas, J. S., Roubin, G. S., King, S. B. Multicenter study of percutaneous trans-luminal angioplasty for right coronary-artery ostial stenosis Journal of the American College of Cardiology  1987 9:1214-1218  PMID:2953771
  • Myler, R. K., Topol, E. J., Shaw, R. E., Stertzer, S. H., Clark, D. A., Fishman, J., Murphy, M. C. Multiple vessel coronary angioplasty - classification, results, and patterns of restenosis in 494 consecutive patients Catheterization and Cardiovascular Diagnosis  1987 13:1-15  DOI:10.1002/ccd.1810130102  PMID:2949849
  • Kircher, B. J., Topol, E. J., Oneill, W. W., Pitt, B. Prediction of infarct coronary-artery recanalization after intravenous thrombolytic therapy American Journal of Cardiology  1987 59:513-515  DOI:10.1016/0002-9149(87)91158-1  PMID:3825886
  • Wind, B. E., Snider, A. R., Buda, A. J., Oneill, W. W., Topol, E. J., Dilworth, L. R. Pulsed doppler assessment of left-ventricular diastolic filling in coronary-artery disease before and immediately after coronary angioplasty American Journal of Cardiology  1987 59:1041-1046  DOI:10.1016/0002-9149(87)90845-9  PMID:2953227
  • Papadopoulos, S. M., Chandler, W. F., Salamat, M. S., Topol, E. J., Sackellares, J. C. Recombinant human tissue-type plasminogen-activator therapy in acute thromboembolic stroke Journal of Neurosurgery  1987 67:394-398  DOI:10.3171/jns.1987.67.3.0394  PMID:3112328
  • Topol, E. J., Califf, R. M., Kereiakes, D. J., George, B. S. Thrombolysis and angioplasty in myocardial-infarction (tami) trial Journal of the American College of Cardiology  1987 10:B65-B74
  • Walsh, D. G., Kaplan, L. R., Burney, R. E., Topol, E. J., Oneill, W. W. Use of tissue plasminogen-activator in the emergency department for acute myocardial-infarction Annals of Emergency Medicine  1987 16:243-247  DOI:10.1016/s0196-0644(87)80166-x  PMID:2949679
  • Sanz, M. L., Mancini, J., Lefree, M. T., Mickelson, J. K., Starling, M. R., Vogel, R. A., Topol, E. J. Variability of quantitative digital subtraction coronary angiography before and after percutaneous trans-luminal coronary angioplasty American Journal of Cardiology  1987 60:55-60  DOI:10.1016/0002-9149(87)90984-2  PMID:2955693
  • Topol, E. J., Biern, R. O., Reitz, B. A. Cardiac papillary fibroelastoma and stroke - echocardiographic diagnosis and guide to excision American Journal of Medicine  1986 80:129-132  DOI:10.1016/0002-9343(86)90063-x  PMID:3942145
  • Topol, E. J., Lerman, B. B., Baughman, K. L., Platia, E. V., Griffith, L. S. C. Denovo refractory ventricular tachyarrhythmias after coronary revascularization American Journal of Cardiology  1986 57:57-59  DOI:10.1016/0002-9149(86)90951-3  PMID:3484603
  • Topol, E. J., Herskowitz, A., Hutchins, G. M. Massive hemorrhagic myocardial-infarction after coronary thrombolysis American Journal of Medicine  1986 81:339-343  DOI:10.1016/0002-9343(86)90275-5  PMID:3090880
  • Topol, E. J., Fung, A. Y., Kline, E., Kaplan, L., Landis, D., Strozeski, M., Burney, R. E., Pitt, B., Oneill, W. W. Safety of helicopter transport and out-of-hospital intravenous fibrinolytic therapy in patients with evolving myocardial-infarction Catheterization and Cardiovascular Diagnosis  1986 12:151-155  PMID:3089627
  • Fung, A. Y., Lai, P., Topol, E. J., Bates, E. R., Bourdillon, P. D. V., Walton, J. A., Mancini, G. B. J., Kryski, T., Pitt, B., Oneill, W. W. Value of percutaneous trans-luminal coronary angioplasty after unsuccessful intravenous streptokinase therapy in acute myocardial-infarction American Journal of Cardiology  1986 58:686-691  DOI:10.1016/0002-9149(86)90338-3  PMID:2945418
  • Topol, E. J., Eha, J. E., Brin, K. P., Shapiro, E. P., Weiss, J. L., Riegel, M. B., Gottlieb, S. O., Brinker, J. A. Applicability of percutaneous trans-luminal coronary angioplasty to patients with recombinant tissue plasminogen-activator mediated thrombolysis Catheterization and Cardiovascular Diagnosis  1985 11:337-348  DOI:10.1002/ccd.1810110402  PMID:2931176
  • Topol, E. J., Bell, W. R., Weisfeldt, M. L. Coronary thrombolysis with recombinant tissue-type plasminogen-activator - a hematologic and pharmacologic study Annals of Internal Medicine  1985 103:837-843  PMID:3933395
  • Topol, E. J., Traill, T. A., Fortuin, N. J. Hypertensive hypertrophic cardiomyopathy of the elderly New England Journal of Medicine  1985 312:277-283  DOI:10.1056/nejm198501313120504  PMID:2857050
  • Topol, E. J., Weiss, J. L., Brinker, J. A., Brin, K. P., Gottlieb, S. O., Becker, L. C., Bulkley, B. H., Chandra, N., Flaherty, J. T., Gerstenblith, G., Gottlieb, S. H., Guerci, A. D., et al. Regional wall motion improvement after coronary thrombolysis with recombinant tissue plasminogen-activator - importance of coronary angioplasty Journal of the American College of Cardiology  1985 6:426-433  PMID:3160757
  • Topol, E. J., Myler, R. K., Stertzer, S. H. Selection of dilatation hardware for ptca - 1985 Catheterization and Cardiovascular Diagnosis  1985 11:629-637  DOI:10.1002/ccd.1810110613  PMID:2936462
  • Topol, E. J., Ciuffo, A. A., Pearson, T. A., Dillman, J., Builder, S., Grossbard, E., Weisfeldt, M. L., Bulkley, B. H. Thrombolysis with recombinant tissue plasminogen-activator in atherosclerotic thrombotic occlusion Journal of the American College of Cardiology  1985 5:85-91  PMID:4038373
  • Topol, E. J., Humphrey, L. S., Borkon, A. M., Baumgartner, W. A., Dorsey, D. L., Reitz, B. A., Weiss, J. L. Value of intraoperative left-ventricular microbubbles detected by trans-esophageal two-dimensional echocardiography in predicting neurologic outcome after cardiac operations American Journal of Cardiology  1985 56:773-775  DOI:10.1016/0002-9149(85)91134-8  PMID:4061300
  • Collen, D., Topol, E. J., Tiefenbrunn, A. J., Gold, H. K., Weisfeldt, M. L., Sobel, B. E., Leinbach, R. C., Brinker, J. A., Ludbrook, P. A., Yasuda, I., Bulkley, B. H., Robison, A. K., et al. Coronary thrombolysis with recombinant human tissue-type plasminogen-activator - a prospective, randomized, placebo-controlled trial Circulation  1984 70:1012-1017  PMID:6388898
  • Topol, E. J., Fortuin, N. J. Coronary-artery spasm and cardiac-arrest in carcinoid heart-disease American Journal of Medicine  1984 77:950-952  DOI:10.1016/0002-9343(84)90549-7  PMID:6496552
  • Topol, E. J., Weiss, J. L., Guzman, P. A., Dorseylima, S., Blanck, T. J. J., Humphrey, L. S., Baumgartner, W. A., Flaherty, J. T., Reitz, B. A. Immediate improvement of dysfunctional myocardial segments after coronary revascularization - detection by intraoperative trans-esophageal echocardiography Journal of the American College of Cardiology  1984 4:1123-1134  PMID:6334108
  • Lerman, B. B., Topol, E. J., Platia, E. V., Baughman, K. L. Orthostatic atrial tachycardia - autonomic influence on atrial pacemakers American Journal of Cardiology  1984 53:1406-1408  DOI:10.1016/0002-9149(84)90105-x  PMID:6711447
  • Topol, E. J., Lerman, B. B. Hypomagnesemic torsades de pointes American Journal of Cardiology  1983 52:1367-1368  DOI:10.1016/0002-9149(83)90611-2  PMID:6650429
  • Topol, E. J., Goldschlager, N., Ports, T. A., Dicarlo, L. A., Schiller, N. B., Botvinick, E. H., Chatterjee, K. Hemodynamic benefit of atrial-pacing in right ventricular myocardial-infarction Annals of Internal Medicine  1982 96:594-597  PMID:7073152