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Topol, Eric
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Topol, Eric

Faculty Member
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Positions

  • 2017 - Executive Vice President, Scripps Research
  • 2017 - Professor of Genomics, Molecular Medicine , Scripps Research
  • 2009 - Gary and Mary West Endowed Chair of Innovative Medicine, Scripps Health
  • 2009 - Co-Founder and Vice-Chairman, West Health Institute
  • 2007 - Chief Academic Officer, Scripps Health
  • 2007 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2007 - Director, Translational Institute , Scripps Research
  • 2007 - 2017 Professor of Genomics, Molecular and Experimental Medicine (MEM) , Scripps Research
  • 2003 - 2006 Professor of Genetics, Case Western Reserve University
  • 1991 - 2006 Chairman, Department of Cardiovascular Medicine, Cleveland Clinic
  • 2002 - 2005 Founder and Provost, Cleveland Clinic Lerner College of Medicine of Case Western University
  • 2000 - 2005 Chief Academic Officer, Cleveland Clinic
  • 1985 - 1991 Professor with Tenure, Department of Internal Medicine, University of Michigan
  • 1982 - 1985 Cardiology Fellow, Johns Hopkins University
  • 1979 - 1982 Internal Medicine Resident, University of California, San Francisco
Dr. Eric Topol studies the genome of patients who have particular medical conditions or who have been healthy beyond the 8th decade to determine variants associated with the phenotype. His research moves this information forward in medicine to provide individualization of medical care in the future.

Research Areas research areas

  • Diabetes (UMLS)
  • Heart Disease (UMLS)
  • Obesity (UMLS)

Contact

  • etopol@scripps.edu

Websites

  • Eric Topol, M.D. (TSRI)
  • Eric Topol, M.D. (Scripps Health)
  • Laboratory Website
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Publications

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  • academic article

    • Burton, D. R., Topol, E. J. Toward superhuman SARS-CoV-2 immunity? Nature Medicine  2021 27:5-6  DOI:10.1038/s41591-020-01180-x  PMID:33257892
    • Quer, G., Radin, J. M., Gadaleta, M., Baca-Motes, K., Ariniello, L., Ramos, E., Kheterpal, V., Topol, E. J., Steinhubl, S. R. Wearable sensor data and self-reported symptoms for COVID-19 detection Nature Medicine  2021 27:73-77  DOI:10.1038/s41591-020-1123-x  PMID:33122860
    • Topol, E. Which Country Has the World's Best Health Care? Nature  2020 582:331-333
    • Milstein, A., Topol, E. J. Computer vision's potential to improve health care Lancet  2020 395:1537-1537  DOI:10.1016/s0140-6736(20)31090-4  PMID:32416778
    • Keane, P. A., Topol, E. J. Digital medicine Medicine and meteorology: Cloud, connectivity, and care Lancet  2020 395:1334-1334  PMID:32334694
    • Nagendran, M., Chen, Y., Lovejoy, C. A., Gordon, A. C., Komorowski, M., Harvey, H., Topol, E. J., Ioannidis, J. P. A., Collins, G. S., Maruthappu, M. Artificial intelligence versus clinicians: systematic review of design, reporting standards, and claims of deep learning studies BMJ-British Medical Journal  2020 368  DOI:10.1136/bmj.m689  PMID:32213531  PMCID:PMC7190037
    • Dorsey, E. R., Topol, E. J. Telemedicine 2020 and the next decade Lancet  2020 395:859-859  PMID:32171399
    • Berzin, T. M., Topol, E. J. Adding artificial intelligence to gastrointestinal endoscopy Lancet  2020 395:485-485  PMID:32061286
    • Quer, G., Gouda, P., Galarnyk, M., Topol, E. J., Steinhubl, S. R. Inter- and intraindividual variability in daily resting heart rate and its associations with age, sex, sleep, BMI, and time of year: Retrospective, longitudinal cohort study of 92,457 adults PLoS One  2020 15  DOI:10.1371/journal.pone.0227709  PMID:32023264  PMCID:PMC7001906
    • Muse, E. D., Topol, E. J. A brighter future for kidney disease? Lancet  2020 395:179-179  PMID:31954451
    • Jaiswal, S. J., Quer, G., Galarnyk, M., Steinhubl, S. R., Topol, E. J., Owens, R. L. Association of Sleep Duration and Variability With Body Mass Index Sleep Measurements in a Large US Population of Wearable Sensor Users JAMA Internal Medicine  2020  DOI:10.1001/jamainternmed.2020.2834  PMID:32926073  PMCID:PMC7490746
    • Topol, E. J. COVID-19 can affect the heart Science  2020 370:408-409  DOI:10.1126/science.abe2813  PMID:32967937
    • Verghese, A., Topol, E. Courage in a climate of fear Science Translational Medicine  2020 12  DOI:10.1126/scitranslmed.abf2461  PMID:33077677
    • Muse, E. D., Topol, E. J. Digital medicine Guiding ultrasound image capture with artificial intelligence Lancet  2020 396:749-749  PMID:32919501
    • Kanchan, K., Iyer, K., Yanek, L. R., Carcamo-Orive, I., Taub, M. A., Malley, C., Baldwin, K., Becker, L. C., Broeckel, U., Cheng, L. Z., Cowan, C., D'Antonio, M., et al. Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program Stem Cell Research  2020 46  DOI:10.1016/j.scr.2020.101803  PMID:32442913
    • Norgeot, B., Quer, G., Beaulieu-Jones, B. K., Torkamani, A., Dias, R., Gianfrancesco, M., Arnaout, R., Kohane, I. S., Saria, S., Topol, E., Obermeyer, Z., Yu, B., et al. Minimum information about clinical artificial intelligence modeling: the MI-CLAIM checklist Nature Medicine  2020 26:1320-1324  DOI:10.1038/s41591-020-1041-y  PMID:32908275  PMCID:PMC7538196
    • Harvey, H., Topol, E. J. More than meets the AI: refining image acquisition and resolution Lancet  2020 396:1479-1479  PMID:33160557
    • Oran, D. P., Topol, E. J. Prevalence of Asymptomatic SARS-CoV-2 Infection A Narrative Review Annals of Internal Medicine  2020 173:362-367  DOI:10.7326/m20-3012  PMID:32491919  PMCID:PMC7281624
    • Angrist, M., Barrangou, R., Baylis, F., Brokowski, C., Burgio, G., Caplan, A., Chapman, C. R., Church, G. M., Cook-Deegan, R., Cwik, B., Doudna, J. A., Evans, J. H., et al. Reactions to the National Academies/Royal Society Report on Heritable Human Genome Editing Crispr Journal  2020 3:332-349  DOI:10.1089/crispr.2020.29106.man  PMID:33095048
    • Topol, E. J. Welcoming new guidelines for AI clinical research Nature Medicine  2020 26:1318-1320  DOI:10.1038/s41591-020-1042-x  PMID:32908274
    • Salfati, E. L., Spencer, E. G., Topol, S. E., Muse, E. D., Rueda, M., Lucas, J. R., Wagner, G. N., Campman, S., Topol, E. J., Torkamani, A. Re-analysis of whole-exome sequencing data uncovers novel diagnostic variants and improves molecular diagnostic yields for sudden death and idiopathic diseases Genome Medicine  2019 11  DOI:10.1186/s13073-019-0702-2  PMID:31847883  PMCID:PMC6916453
    • Keane, P., Topol, E. Digital medicine Reinventing the eye exam Lancet  2019 394:2141-2141
    • Regev, A., Zhang, F., Jaffee, E., Farrar, J., Nkengasong, J., Topol, E., Partridge, L., Mundel, T., Tabernero, J., Sabeti, P., Toreele, E. Looking forward 25 years: the future of medicine Nature Medicine  2019 25:1804-1807  DOI:10.1038/s41591-019-0693-y  PMID:31806889
    • Esteva, A., Topol, E. Can skin cancer diagnosis be transformed by AI? Lancet  2019 394:1795-1795
    • Chan, J., Raju, S. C., Topol, E. Towards a tricorder for diagnosing paediatric conditions Lancet  2019 394:907-907  DOI:10.1016/s0140-6736(19)32087-2
    • Muse, E. D., Topol, E. J. Digital orthodoxy of human data collection Lancet  2019 394:556-556  PMID:31423988
    • Topol, E. J. Everybody wants to go to heaven but nobody wants to die: bioethics and the transformation of health care in america Nature  2019 572:308-309  DOI:10.1038/d41586-019-02412-y
    • Pandey, A. C., Topol, E. J. Dispense with supplements for improving heart outcomes Annals of Internal Medicine  2019 171:216-217  DOI:10.7326/m19-1498  PMID:31284306
    • Topol, E. J. Deep learning detects impending organ injury Nature  2019 572:36-37  DOI:10.1038/d41586-019-02308-x  PMID:31367025
    • Topol, E., Lee, K. F. It takes a planet Nature Biotechnology  2019 37:858-861  DOI:10.1038/s41587-019-0214-z  PMID:31375799
    • Oran, D. P., Topol, E. J. Digital medicine The rise of the virtualist Lancet  2019 394:17-17  DOI:10.1377/hblog20180319.150005
    • Topol, E. Man and machine medicine Scientist  2019 33:61-61
    • Topol, E. J. A decade of digital medicine innovation Science Translational Medicine  2019 11  DOI:10.1126/scitranslmed.aaw7610  PMID:31243153
    • Torkamani, A., Topol, E. Polygenic risk scores expand to obesity Cell  2019 177:518-520  DOI:10.1016/j.cell.2019.03.051  PMID:31002792
    • Waalen, J., Peters, M., Ranamukhaarachchi, D., Li, J., Ebner, G., Senkowsky, J., Topol, E. J., Steinhubl, S. R. Real world usage characteristics of a novel mobile health self-monitoring device: Results from the Scanadu Consumer Health Outcomes (SCOUT) Study PLoS One  2019 14  DOI:10.1371/journal.pone.0215468  PMID:30990860  PMCID:PMC6467418
    • Evangelista, L., Steinhubl, S. R., Topol, E. J. Digital health care for older adults Lancet  2019 393:1493-1493  DOI:10.1016/s0140-6736(19)30800-1  PMID:30983579
    • Jaiswal, S. J., Topol, E. J., Steinhubl, S. R. Digitising the way to better sleep health Lancet  2019 393:639-639  DOI:10.1001/jamapsychiatry.2018.2745  PMID:30782334
    • Ensign, S. F., Baca-Motes, K., Steinhubl, S. R., Topol, E. J. Characteristics of the modern-day physician house call Medicine  2019 98  DOI:10.1097/md.0000000000014671  PMID:30813215  PMCID:PMC6408061
    • Kumar, A., Thomas, S. K., Wong, K. C., Lo Sardo, V., Cheah, D. S., Hou, Y. H., Placone, J. K., Tenerelli, K. P., Ferguson, W. C., Torkamani, A., Topol, E. J., Baldwin, K. K., et al. Mechanical activation of noncoding-RNA-mediated regulation of disease-associated phenotypes in human cardiomyocytes Nature Biomedical Engineering  2019 3:137-146  DOI:10.1038/s41551-018-0344-5
    • Hamideh, D., Arellano, B., Topol, E. J., Steinhubl, S. R. Your digital nutritionist Lancet  2019 393:19-19  DOI:10.1016/s0140-6736(18)33170-2  PMID:30614448
    • Spencer, E. G., Topol, E. J. Direct to consumer fitness DNA testing Clinical Chemistry  2019 65:45-47  DOI:10.1373/clinchem.2018.287326  PMID:30274978
    • Topol, E. J. High-performance medicine: the convergence of human and artificial intelligence Nature Medicine  2019 25:44-56  DOI:10.1038/s41591-018-0300-7  PMID:30617339
    • Wineinger, N. E., Barrett, P. M., Zhang, Y., Irfanullah, I., Muse, E. D., Steinhubl, S. R., Topol, E. J. Identification of paroxysmal atrial fibrillation subtypes in over 13,000 individuals Heart Rhythm  2019 16:26-30  DOI:10.1016/j.hrthm.2018.08.012  PMID:30118885
    • Lo Sardo, V., Chubukov, P., Ferguson, W., Kumar, A., Teng, E. L., Duran, M., Zhang, L., Cost, G., Engler, A. J., Urnov, F., Topol, E. J., Torkamani, A., et al. Unveiling the role of the most impactful cardiovascular risk locus through haplotype editing Cell  2018 175:1796-1810  DOI:10.1016/j.cell.2018.11.014  PMID:30528432
    • Tarassenko, L., Topol, E. J. Monitoring jet engines and the health of people JAMA-Journal of the American Medical Association  2018 320:2309-2310  DOI:10.1001/jama.2018.16558  PMID:30453330
    • Wang, F., Wang, I. Z., Ellis, S., Archacki, S., Barnard, J., Hubbard, C., Topol, E. J., Chen, Q., Wang, Q. K. Analysis of causal effect of APOA5 variants on premature coronary artery disease Annals of Human Genetics  2018 82:437-447  DOI:10.1111/ahg.12273  PMID:30024021  PMCID:PMC6188800
    • Torkamani, A., Topol, E. Your genome, on demand MIT Technology Review  2018 121:20-21
    • Radin, J. M., Topol, E. J., Steinhubl, S. R. A digital toolkit for improved maternal health Lancet  2018 392:1107-1107  DOI:10.1016/s0140-6736(18)32294-3
    • Steinhubl, S. R., Topol, E. J. A skin patch for sensing blood pressures Nature Biomedical Engineering  2018 2:633-634  DOI:10.1038/s41551-018-0296-9
    • Quer, G., Nikzad, N., Chieh, A., Normand, A., Vegreville, M., Topol, E. J., Steinhubl, S. R. Home monitoring of blood pressure: short-term changes during serial measurements for 56398 subjects Ieee Journal of Biomedical and Health Informatics  2018 22:1691-1698  DOI:10.1109/jbhi.2017.2776946  PMID:29989995  PMCID:PMC6053341
    • Torkamani, A., Wineinger, N. E., Topol, E. J. The personal and clinical utility of polygenic risk scores Nature Reviews Genetics  2018 19:581-590  DOI:10.1038/s41576-018-0018-x  PMID:29789686
    • Steinhubl, S. R., Topol, E. J. Now we're talking: bringing a voice to digital medicine Lancet  2018 392:627-627
    • Modena, B. D., Bellahsen, O., Nikzad, N., Chieh, A., Parikh, N., Dufek, D. M., Ebner, G., Topol, E. J., Steinhubl, S. Advanced and accurate mobile health tracking devices record new cardiac vital signs Hypertension  2018 72:503-510  DOI:10.1161/hypertensionaha.118.11177  PMID:29967036  PMCID:PMC6044460
    • Song, M. Y., Steinhubl, S. R., Topol, E. J. Digital medicine: The beginning of the end of fingersticks? Lancet  2018 392:203-203  DOI:10.1016/s0140-6736(18)31576-9
    • Steinhubl, S. R., Waalen, J., Edwards, A. M., Ariniello, L. M., Mehta, R. R., Ebner, G. S., Carter, C., Baca-Motes, K., Felicione, E., Sarich, T., Topol, E. J. Effect of a home-based wearable continuous ECG monitoring patch on detection of undiagnosed atrial fibrillation the mSToPS randomized clinical trial JAMA-Journal of the American Medical Association  2018 320:146-155  DOI:10.1001/jama.2018.8102  PMID:29998336
    • Muse, E. D., Torkamani, A., Topol, E. J. When genomics goes digital Lancet  2018 391:2405-2405  DOI:10.1038/s41576-018-0018-x  PMID:29916375
    • Topol, E. Bad blood secrets and lies in a Silicon Valley startup Nature  2018 557:306-307
    • Kim, K. I., Nikzad, N., Quer, G., Wineinger, N. E., Vegreville, M., Normand, A., Schmidt, N., Topol, E. J., Steinhubl, S. Real world home blood pressure variability in over 56,000 individuals with nearly 17 million measurements American Journal of Hypertension  2018 31:566-573  DOI:10.1093/ajh/hpx221  PMID:29365036  PMCID:PMC5905665
    • Telenti, A., Steinhubl, S. R., Topol, E. J. Rethinking the medical record Lancet  2018 391:1013-1013  PMID:29565009
    • Mikk, K. A., Sleeper, H. A., Topol, E. Patient data ownership reply JAMA-Journal of the American Medical Association  2018 319:935-936  DOI:10.1001/jama.2017.21688  PMID:29509862
    • Jha, S., Topol, E. J. Information and artificial intelligence Journal of the American College of Radiology  2018 15:509-511  DOI:10.1016/j.jacr.2017.12.025
    • Steinhubl, S. R., Kim, K. I., Ajayi, T., Topol, E. J. Virtual care for improved global health Lancet  2018 391:419-419  PMID:29407024
    • Dharajiya, N. G., Grosu, D. S., Farkas, D. H., McCullough, R. M., Almasri, E., Sun, Y., Kim, S. K., Jensen, T. J., Saldivar, J. S., Topol, E. J., van den Boom, D., Ehrich, M. Incidental detection of maternal neoplasia in noninvasive prenatal testing Clinical Chemistry  2018 64:329-335  DOI:10.1373/clinchem.2017.277517  PMID:28982650
    • Muse, E. D., Wineinger, N. E., Spencer, E. G., Peters, M., Henderson, R., Zhang, Y., Barrett, P. M., Rivera, S. P., Wohlgemuth, J. G., Devlin, J. J., Shiffman, D., Topol, E. J. Validation of a genetic risk score for atrial fibrillation: A prospective multicenter cohort study PLoS Medicine  2018 15  DOI:10.1371/journal.pmed.1002525  PMID:29534064  PMCID:PMC5849279
    • Bansal, V., Gassenhuber, J., Phillips, T., Oliveira, G., Harbaugh, R., Villarasa, N., Topol, E. J., Seufferlein, T., Boehm, B. O. Spectrum of mutations in monogenic diabetes genes identified from high-throughput DNA sequencing of 6888 individuals BMC Medicine  2017 15  DOI:10.1186/s12916-017-0977-3  PMID:29207974  PMCID:PMC5717832
    • Steinhubl, S. R., McGovern, P., Dylan, J., Topol, E. J. The digitised clinical trial Lancet  2017 390:2135-2135  PMID:29143747
    • Mikk, K. A., Sleeper, H. A., Topol, E. J. The pathway to patient data ownership and better health JAMA-Journal of the American Medical Association  2017 318:1433-1434  DOI:10.1001/jama.2017.12145  PMID:28973063
    • Muse, E. D., Kramer, E. R., Wang, H. Y., Barrett, P., Parviz, F., Novotny, M. A., Lasken, R. S., Jatkoe, T. A., Oliveira, G., Peng, H. F., Lu, J., Connelly, M. C., et al. A whole blood molecular signature for acute myocardial infarction Scientific Reports  2017 7  DOI:10.1038/s41598-017-12166-0  PMID:28947747  PMCID:PMC5612952
    • Torkamani, A., Andersen, K. G., Steinhubl, S. R., Topol, E. J. High-Definition Medicine Cell  2017 170:828-843  DOI:10.1016/j.cell.2017.08.007  PMID:28841416
    • Quer, G., Muse, E. D., Nikzad, N., Topol, E. J., Steinhubl, S. R. Digital medicine: Augmenting diagnostic vision with AI Lancet  2017 390:221-221
    • Barrett, P. M., Steinhubl, S. R., Muse, E. D., Topol, E. J. Digitising the mind Lancet  2017 389:1877-1877  PMID:28513442
    • Muse, E. D., Barrett, P. M., Steinhubl, S. R., Topol, E. J. Towards a smart medical home Lancet  2017 389:358-358  PMID:28137686
    • Topol, E. J. Is there an ICD-10 code for hyperbole? JAMA-Journal of the American Medical Association  2017 317:10-11  PMID:28030677
    • Guo, Y., Wang, F., Li, L., Gao, H., Arckacki, S., Wang, I. Z., Barnard, J., Ellis, S., Hubbard, C., Topol, E. J., Chen, Q., Wang, Q. K. Genome-wide linkage analysis of large multiple multigenerational families identifies novel genetic loci for coronary rrtery disease Scientific Reports  2017 7  DOI:10.1038/s41598-017-05381-2  PMID:28710368  PMCID:PMC5511258
    • Lo Sardo, V., Ferguson, W., Erikson, G. A., Topol, E. J., Baldwin, K. K., Torkamani, A. Influence of donor age on induced pluripotent stem cells Nature Biotechnology  2017 35:69-74  DOI:10.1038/nbt.3749  PMID:27941802
    • Jha, S., Topol, E. J. Adapting to artificial intelligence radiologists and pathologists as information specialists JAMA-Journal of the American Medical Association  2016 316:2353-2354  DOI:10.1001/jama.2016.17438  PMID:27898975
    • Kim, J. Y., Wineinger, N. E., Taitel, M., Radin, J. M., Akinbosoye, O., Jiang, J., Nikzad, N., Orr, G., Topol, E., Steinhubl, S. Self-monitoring utilization patterns among individuals in an incentivized program for healthy behaviors Journal of Medical Internet Research  2016 18:83-97  DOI:10.2196/jmir.6371  PMID:27856407
    • Radin, J. M., Topol, E. J., Andersen, K. G., Steinhubl, S. R. A laboratory in your pocket Lancet  2016 388:1875-1875  PMID:27751390
    • Torkamani, A., Muse, E. D., Spencer, E. G., Rueda, M., Wagner, G. N., Lucas, J. R., Topol, E. J. Molecular autopsy for sudden unexpected death JAMA-Journal of the American Medical Association  2016 316:1492-1494  PMID:27727376
    • Dorsey, E. R., Topol, E. J. State of Telehealth REPLY New England Journal of Medicine  2016 375:1400-1400
    • Topol, E. The evangelist of individualized medicine Technology Review  2016 119:91-92
    • Topol, E. Digital medicine: empowering both patients and clinicians Lancet  2016 388:740-741  PMID:27560260
    • Steinhubl, S. R., Muse, E. D., Barrett, P. M., Topol, E. J. Off the cuff : rebooting blood pressure treatment Lancet  2016 388:749-749  PMID:27560266
    • Gollamudi, S. S., Topol, E. J., Wineinger, N. E. A framework for smartphone-enabled, patient-generated health data analysis PeerJ  2016 4  DOI:10.7717/peerj.2284  PMID:27547580  PMCID:PMC4975026
    • Topol, E. J. Money back guarantees for non-reproducible results? BMJ-British Medical Journal  2016 353  DOI:10.1136/bmj.i2770  PMID:27221803
    • Erikson, G. A., Bodian, D. L., Rueda, M., Molparia, B., Scott, E. R., Scott-Van Zeeland, A. A., Topol, S. E., Wineinger, N. E., Niederhuber, J. E., Topol, E. J., Torkamani, A. Whole-genome sequencing of a healthy aging cohort Cell  2016 165:1002-1011  DOI:10.1016/j.cell.2016.03.022  PMID:27114037  PMCID:PMC4860090
    • Steinhubl, S. R., Mehta, R. R., Ebner, G. S., Ballesteros, M. M., Waalen, J., Steinberg, G., Van Crocker Jr., P., Felicione, E., Carter, C. T., Edmonds, S., Honcz, J. P., Miralles, G. D., et al. Rationale and design of a home-based trial using wearable sensors to detect asymptomatic atrial fibrillation in a targeted population: The mHealth Screening To Prevent Strokes (mSToPS) trial American Heart Journal  2016 175:77-85  DOI:10.1016/j.ahj.2016.02.011  PMID:27179726
    • Barrett, P. M., Topol, E. J. Smartphone Medicine It Professional  2016 18:52-54
    • Barrett, P. M., Topol, E. J. To truly look inside Lancet  2016 387:1268-1269  PMID:27035018
    • Bloss, C. S., Wineinger, N. E., Peters, M., Boeldt, D. L., Ariniello, L., Kim, J. Y., Sheard, J., Komatireddy, R., Barrett, P., Topol, E. J. A prospective randomized trial examining health care utilization in individuals using multiple smartphone-enabled biosensors PeerJ  2016 4  DOI:10.7717/peerj.1554  PMID:26788432  PMCID:PMC4715435
    • Dorsey, E. R., Topol, E. J. State of telehealth New England Journal of Medicine  2016 375:154-161  DOI:10.1056/NEJMra1601705  PMID:27410924
    • Wilbanks, J. T., Topol, E. J. Stop the privatization of health data Nature  2016 535:345-348  PMID:27443724
    • Filkins, B. L., Kim, J. Y., Roberts, B., Armstrong, W., Miller, M. A., Hultner, M. L., Castillo, A. P., Ducom, J. C., Topol, E. J., Steinhubl, S. R. Privacy and security in the era of digital health: what should translational researchers know and do about it? American Journal of Translational Research  2016 8:1560-1580  PMID:27186282  PMCID:PMC4859641
    • Lauer, M. S., Krumholz, H. M., Topol, E. J. Time for a prepublication culture in clinical research? Lancet  2015 386:2447-2449  DOI:10.1016/S0140-6736(15)01177-0  PMID:26738703  PMCID:PMC5082701
    • Bloss, C. S., Zeeland, A. A. S. V., Topol, S. E., Darst, B. F., Boeldt, D. L., Erikson, G. A., Bethel, K. J., Bjork, R. L., Friedman, J. R., Hwynn, N., Patay, B. A., Pockros, P. J., et al. A genome sequencing program for novel undiagnosed diseases Genetics in Medicine  2015 17:995-1001  DOI:10.1038/gim.2015.21  PMID:25790160  PMCID:PMC4575596
    • Harper, A. R., Nayee, S., Topol, E. J. Protective alleles and modifier variants in human health and disease Nature Reviews Genetics  2015 16:689-701  DOI:10.1038/nrg4017  PMID:26503796
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    • Topol, E. J. Novel antithrombotic approaches to coronary-artery disease American Journal of Cardiology  1995 75:B27-B33  DOI:10.1016/0002-9149(95)80007-f
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    • Boehrer, J. D., Kereiakes, D. J., Navetta, F. I., Califf, R. M., Topol, E. J. Effects of profound platelet inhibition with c7e3 before coronary angioplasty on complications of coronary-bypass survey American Journal of Cardiology  1994 74:1166-1170  DOI:10.1016/0002-9149(94)90474-x  PMID:7977081
    • Kleiman, N. S., White, H. D., Ohman, E. M., Ross, A. M., Woodlief, L. H., Califf, R. M., Holmes, D. R., Bates, E., Pfisterer, M., Vahanian, A., Topol, E. J. Mortality within 24 hours of thrombolysis for myocardial-infarction - the importance of early reperfusion Circulation  1994 90:2658-2665  PMID:7994805
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    • Maclsaac, A. I., Ellis, S. G., Muller, D. W., Topol, E. J., Whitlow, P. L. Comparison of 3 coronary stents - clinical and angiographic outcome after elective placement in 134 consecutive patients Catheterization and Cardiovascular Diagnosis  1994 33:199-204  DOI:10.1002/ccd.1810330302  PMID:7874711
    • Savage, M. P., Fischman, D. L., Schatz, R. A., Teirstein, P. S., Leon, M. B., Baim, D., Ellis, S. G., Topol, E. J., Hirshfeld, J. W., Cleman, M. W., Buchbinder, M., Bailey, S., et al. Long-term angiographic and clinical outcome after implantation of a balloon-expandable stent in the native coronary circulation Journal of the American College of Cardiology  1994 24:1207-1212  PMID:7930240
    • Ellis, S. G., Dasilva, E. R., Heyndrickx, G., Talley, J. D., Cernigliaro, C., Steg, G., Spaulding, C., Nobuyoshi, M., Erbel, R., Vassanelli, C., Topol, E. J. Randomized comparison of rescue angioplasty with conservative management of patients with early failure of thrombolysis for acute anterior myocardial-infarction Circulation  1994 90:2280-2284  PMID:7955184
    • Mark, D. B., Naylor, C. D., Hlatky, M. A., Califf, R. M., Topol, E. J., Granger, C. B., Knight, J. D., Nelson, C. L., Lee, K. L., Clappchanning, N. E., Sutherland, W., Pilote, L., et al. Use of medical resources and quality-of-life after acute myocardial-infarction in canada and the united-states New England Journal of Medicine  1994 331:1130-1135  DOI:10.1056/nejm199410273311706  PMID:7935638
    • Lincoff, A. M., Topol, E. J., Ellis, S. G. Local-drug delivery for the prevention of restenosis - fact, fancy, and future Circulation  1994 90:2070-2084  PMID:7923695
    • Tcheng, J. E., Ellis, S. G., George, B. S., Kereiakes, D. J., Kleiman, N. S., Talley, J. D., Wang, A. L., Weisman, H. F., Califf, R. M., Topol, E. J. Pharmacodynamics of chimeric glycoprotein iib/iiia integrin antiplatelet antibody fab 7e3 in high-risk coronary angioplasty Circulation  1994 90:1757-1764  PMID:7923659
    • Topol, E., Califf, R., Vandewerf, F., Ardissino, D., Armstrong, P., Aylward, P., Barbash, G., Bates, E., Beatt, K., Betriu, A., Chesebro, J., Col, J., et al. Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes Circulation  1994 90:1631-1637  PMID:7923645
    • Nissen, S. E., Pepine, C. J., Bashore, T. M., Block, P. C., Bonchek, L. I., Brinker, J. A., Carabello, B., Douglas, J. S., Elion, J. L., Hirshfeld, J. W., Holmes, D. R., Johnson, W. L., et al. Cardiac angiography without cine film - erecting a tower-of-babel in the cardiac-catheterization laboratory Journal of the American College of Cardiology  1994 24:834-837  PMID:8077561
    • Lefkovits, J., Topol, E. J. Direct thrombin inhibitors in cardiovascular medicine Circulation  1994 90:1522-1536  PMID:8087958
    • Steinberg, J. S., Hochman, J. S., Morgan, C. D., Dorian, P., Naylor, C. D., Theroux, P., Topol, E. J., Armstrong, P. W. Effects of thrombolytic therapy administered 6 to 24 hours after myocardial-infarction on the signal-averaged ecg - results of a multicenter randomized trial Circulation  1994 90:746-752  PMID:8044943
    • Faxon, D. P., Spiro, T. E., Minor, S., Cote, G., Douglas, J., Gottlieb, R., Califf, R., Dorosti, K., Topol, E., Gordon, J. B., Ohmen, M., Raizner, A., et al. Low-molecular-weight heparin in prevention of restenosis after angioplasty - results of enoxaparin restenosis (era) trial Circulation  1994 90:908-914  PMID:8044962
    • Holmes, D. R., Topol, E. J., Adelman, A. G., Cohen, E. A., Califf, R. M. Randomized trials of directional coronary atherectomy - implications for clinical-practice and future investigation Journal of the American College of Cardiology  1994 24:431-439  PMID:8034880
    • Braunwald, E., Jones, R. H., Mark, D. B., Brown, J., Brown, L., Cheitlin, M. D., Concannon, C. A., Cowan, M., Edwards, C., Fuster, V., Goldman, L., Green, L. A., et al. Diagnosing and managing unstable angina Circulation  1994 90:613-622  PMID:8026048
    • Wall, T. C., Califf, R. M., Blankenship, J., Talley, J. D., Tannenbaum, M., Schwaiger, M., Gacioch, G., Cohen, M. D., Sanz, M., Leimberger, J. D., Topol, E. J. Intravenous fluosol in the treatment of acute myocardial-infarction - results of the thrombolysis and angioplasty in myocardial-infarction-9 trial Circulation  1994 90:114-120  PMID:8025985
    • Brown, D. L., Macisaac, A. I., Topol, E. J. Pulmonary hemorrhage after intracoronary stent placement Journal of the American College of Cardiology  1994 24:91-94  PMID:8006287
    • Ellis, S. G., Lincoff, A. M., George, B. S., Kereiakes, D. J., Ohman, E. M., Krucoff, M. W., Califf, R. M., Topol, E. J. Randomized evaluation of coronary angioplasty for early timi-2 flow after thrombolytic therapy for the treatment of acute myocardial-infarction - a new look at an old study Coronary Artery Disease  1994 5:611-615  DOI:10.1097/00019501-199407000-00009  PMID:7952423
    • Defranco, A. C., Topol, E. J. Invasive strategies for acute myocardial-infarction in the elderly Cardiology in the Elderly  1994 2:274-289
    • Lee, K. L., Califf, R. M., Simes, J., Vandewerf, F., Topol, E. J. Holding gusto up to the light Annals of Internal Medicine  1994 120:876-881  PMID:8154647
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    • Topol, E. J., Califf, R. M., Weisman, H. F., Ellis, S. G., Tcheng, J. E., Worley, S., Ivanhoe, R., George, B. S., Fintel, D., Weston, M., Sigmon, K., Anderson, K. M., et al. Randomized trial of coronary intervention with antibody against platelet iib/iiia integrin for reduction of clinical restenosis - results at 6 months Lancet  1994 343:881-886  DOI:10.1016/s0140-6736(94)90007-8  PMID:7908357
    • Califf, R. M., Shadoff, N., Valett, N., Bates, E., Galeana, A., Knopf, W., Shaftel, J., Bender, M. J., Aversano, T., Raqueno, J., Gurbel, P., Cowfer, J., et al. Use of a monoclonal-antibody directed against the platelet glycoprotein iib/iiia receptor in high-risk coronary angioplasty New England Journal of Medicine  1994 330:956-961  PMID:8121459
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    • Rosenschein, U., Ellis, S. G., Haudenschild, C. C., Yakubov, S. J., Muller, D. W. M., Dick, R. J., Topol, E. J. Comparison of histopathologic coronary lesions obtained from directional atherectomy in stable angina versus acute coronary syndromes American Journal of Cardiology  1994 73:508-510  DOI:10.1016/0002-9149(94)90683-1  PMID:8141093
    • Holmes, D. R., Topol, E. J. Dilate or debulk Cleveland Clinic Journal of Medicine  1994 61:124-126  PMID:8194176
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    • Topol, E. J., Califf, R. M. Scorecard cardiovascular medicine - its impact and future-directions Annals of Internal Medicine  1994 120:65-70  PMID:8250458
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    • Ross, A. M., Simoons, M. L., Lundergan, C., Thompson, M., Reiner, J., Deychak, Y., Rohrbeck, S., Coyne, K., Walker, P., Cho, S., Greenhouse, S., Lee, K., et al. The effects of tissue-plasminogen activator, streptokinase, or both on coronary-artery patency, ventricular-function, and survival after acute myocardial-infarction New England Journal of Medicine  1993 329:1615-1622  PMID:8232430
    • Bernardi, M. M., Califf, R. M., Kleiman, N., Ellis, S. G., Topol, E. J. Lack of usefulness of prolonged bleeding times in predicting hemorrhagic events in patients receiving the 7e3 glycoprotein iib/iiia platelet antibody American Journal of Cardiology  1993 72:1121-1125  DOI:10.1016/0002-9149(93)90979-m  PMID:8237799
    • Brown, D. L., Topol, E. J. Stroke complicating percutaneous coronary revascularization American Journal of Cardiology  1993 72:1207-1209  DOI:10.1016/0002-9149(93)90998-r  PMID:8237818
    • Ohman, E. M., Topol, E. J., Califf, R. M., Bates, E. R., Ellis, S. G., Kereiakes, D. J., George, B. S., Samaha, J. K., Kline, E., Sigmon, K. N., Stack, R. S. An analysis of the cause of early mortality after administration of thrombolytic therapy Coronary Artery Disease  1993 4:957-964  DOI:10.1097/00019501-199311000-00002  PMID:8173712
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    • Nath, F. C., Muller, D. W. M., Rosenschein, U., Ellis, S. G., Topol, E. J. Heparin monitoring during coronary intervention - activated clotting time versus activated partial thromboplastin time Canadian Journal of Cardiology  1993 9:797-801  PMID:8281479
    • Cowley, M. J., Vandermael, M., Topol, E. J., Whitlow, P. L., Dean, L. S., Bulle, T. M., Ellis, S. G. Is traditionally defined complete revascularization needed for patients with multivessel disease treated by elective coronary angioplasty Journal of the American College of Cardiology  1993 22:1289-1297  PMID:8227782
    • Baim, D. S., Hinohara, T., Holmes, D., Topol, E., Pinkerton, C., King, S. B., Whitlow, P., Kereiakes, D., Farley, B., Simpson, J. B. Results of directional coronary atherectomy during multicenter preapproval testing American Journal of Cardiology  1993 72:6E-11E  DOI:10.1016/0002-9149(93)91032-d  PMID:8213572
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    • Hampton, J., Wilcox, R., Armstrong, P., Aylward, P., Bett, N., Charbonnier, B., Gulba, D., Heikkila, J., Jensen, G., Lopezbescos, L., Moulopoulos, S., Seabragomes, R., et al. Late assessment of thrombolytic efficacy (late) study with alteplase 6-24 hours after onset of acute myocardial-infarction Lancet  1993 342:759-766  PMID:8103874
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    • George, B. S., Voorhees, W. D., Roubin, G. S., Fearnot, N. E., Pinkerton, C. A., Raizner, A. E., King, S. B., Holmes, D. R., Topol, E. J., Kereiakes, D. J., Hartzler, G. O. Multicenter investigation of coronary stenting to treat acute or threatened closure after percutaneous transluminal coronary angioplasty - clinical and angiographic outcomes Journal of the American College of Cardiology  1993 22:135-143  PMID:8509533
    • Defeyter, Pimj, Vansuylen, R. J., Dejaegere, P. P. T., Topol, E. J., Serruys, P. W. Balloon angioplasty for the treatment of lesions in saphenous-vein bypass grafts Journal of the American College of Cardiology  1993 21:1539-1549  PMID:8496517
    • Casale, P. N., Whitlow, P. L., Franco, I., Grigera, F., Pashkow, F. J., Topol, E. J. Comparison of major complication rates with new atherectomy devices for percutaneous coronary intervention in women versus men American Journal of Cardiology  1993 71:1221-1223  DOI:10.1016/0002-9149(93)90650-2  PMID:8480650
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    • Topol, E. J., Bonan, R., Jewitt, D., Sigwart, U., Kakkar, V. V., Rothman, M., Debono, D., Ferguson, J., Willerson, J. T., Strony, J., Ganz, P., Cohen, M. D., et al. Use of a direct antithrombin, hirulog, in place of heparin during coronary angioplasty Circulation  1993 87:1622-1629  PMID:8491018
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    • Lincoff, A. M., Topol, E. J., Chapekis, A. T., George, B. S., Candela, R. J., Muller, D. W. M., Zimmerman, C. A., Ellis, S. G. Intracoronary stenting compared with conventional therapy for abrupt vessel closure complicating coronary angioplasty - a matched case-control study Journal of the American College of Cardiology  1993 21:866-875  PMID:8450155
    • Granger, C. B., Califf, R. M., Young, S., Candela, R., Samaha, J., Worley, S., Kereiakes, D. J., Topol, E. J. Outcome of patients with diabetes-mellitus and acute myocardial-infarction treated with thrombolytic agents Journal of the American College of Cardiology  1993 21:920-925  PMID:8450161
    • Sane, D. C., Califf, R. M., Sigmon, K. N., Topol, E. J., Stump, D. C. Effect of heparin administration on fibrinogenolysis during thrombolytic therapy with tissue plasminogen activator for acute myocardial infarction Fibrinolysis  1993 7:103-107  DOI:10.1016/0268-9499(93)90030-y
    • Wall, T. C., Califf, R. M., Ellis, S. G., Sigmon, K., Kereiakes, D., George, B. S., Samaha, J., Sane, D., Stump, D. C., Stack, R. S., Topol, E. J. Lack of impact of early catheterization and fibrin specificity on bleeding complications after thrombolytic therapy Journal of the American College of Cardiology  1993 21:597-603  PMID:8436740
    • Popma, J. J., Decesare, N. B., Pinkerton, C. A., Kereiakes, D. J., Whitlow, P., King, S. B., Topol, E. J., Holmes, D. R., Leon, M. B., Ellis, S. G. Quantitative-analysis of factors influencing late lumen loss and restenosis after directional coronary atherectomy American Journal of Cardiology  1993 71:552-557  DOI:10.1016/0002-9149(93)90510-j  PMID:8438740
    • Nath, F. C., Muller, D. W. M., Ellis, S. G., Rosenschein, U., Chapekis, A., Quain, L., Zimmerman, C., Topol, E. J. Thrombosis of a flexible coil coronary stent - frequency, predictors and clinical outcome Journal of the American College of Cardiology  1993 21:622-627  PMID:8436743
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    • Ellis, S. G., Tcheng, J. E., Navetta, F. I., Muller, D. W. M., Weisman, H. F., Smith, C., Anderson, K. M., Califf, R. M., Topol, E. J. Safety and antiplatelet effect of murine monoclonal-antibody 7e3 fab directed against platelet glycoprotein-iib/iiia in patients undergoing elective coronary angioplasty Coronary Artery Disease  1993 4:167-175  DOI:10.1097/00019501-199302000-00007  PMID:8269208
    • Lincoff, A. M., Topol, E. J. Illusion of reperfusion. Does anyone achieve optimal reperfusion during acute myocardial infarction? Circulation  1993 87:1792-1805  PMID:8353902
    • Doorey, A. J., Michelson, E. L., Topol, E. J. Thrombolytic therapy of acute myocardial-infarction - keeping the unfulfilled promises JAMA-Journal of the American Medical Association  1992 268:3108-3114  DOI:10.1001/jama.268.21.3108  PMID:1433742
    • Sutton, J. M., Topol, E. J. Left ventricular function assessment and acute myocardial infarction Current Opinion in Cardiology  1992 7:1035-1045  DOI:10.1097/00001573-199212000-00016
    • Ellis, S. G., Savage, M., Fischman, D., Baim, D. S., Leon, M., Goldberg, S., Hirshfeld, J. W., Cleman, M. W., Teirstein, P. S., Walker, C., Bailey, S., Buchbinder, M., et al. Restenosis after placement of palmaz-schatz stents in native coronary-arteries - initial results of a multicenter experience Circulation  1992 86:1836-1844  PMID:1451256
    • Popma, J. J., Califf, R. M., Ellis, S. G., George, B. S., Kereiakes, D. J., Samaha, J. K., Worley, S. J., Anderson, J. L., Stump, D., Woodlief, L., Sigmon, K., Wall, T. C., et al. Mechanism of benefit of combination thrombolytic therapy for acute myocardial-infarction - a quantitative angiographic and hematologic study Journal of the American College of Cardiology  1992 20:1305-1312  PMID:1430679
    • Rosenschein, U., Yakubov, S. J., Guberinich, D., Bach, D. S., Sonda, P. L., Abrams, G. D., Topol, E. J. Shock-wave thrombus ablation, a new method for noninvasive mechanical thrombolysis American Journal of Cardiology  1992 70:1358-1361  DOI:10.1016/0002-9149(92)90775-t  PMID:1442591
    • Ellis, S. G., Mooney, M. R., George, B. S., Dasilva, E. E. R., Talley, J. D., Flanagan, W. H., Topol, E. J., Griffin, B., Samaha, J., Sawicki, E., Mooney, J., Chapekis, A. T., et al. Randomized trial of late elective angioplasty versus conservative management for patients with residual stenoses after thrombolytic treatment of myocardial-infarction Circulation  1992 86:1400-1406  PMID:1423952
    • Williamson, B. D., Muller, D. W. M., Topol, E. J. Should older patients with acute myocardial-infarction receive thrombolytic therapy Drugs & Aging  1992 2:461-468  PMID:1493350
    • Schwartz, R. S., Holmes, D. R., Topol, E. J. The restenosis paradigm revisited - an alternative proposal for cellular mechanisms Journal of the American College of Cardiology  1992 20:1284-1293  PMID:1401633
    • Rosenschein, U., Ellis, S. G., Yakubov, S. J., Haudenschild, C. C., Dick, R. J., Topol, E. J. Histopathologic correlates of coronary lesion angiographic morphology - lessons from a directional atherectomy experience Coronary Artery Disease  1992 3:953-961
    • Grambow, D. W., Topol, E. J. Effect of maximal medical therapy on refractoriness of unstable angina-pectoris American Journal of Cardiology  1992 70:577-581  DOI:10.1016/0002-9149(92)90194-4  PMID:1354937
    • Granger, C. B., Califf, R. M., Topol, E. J. Thrombolytic therapy for acute myocardial-infarction - a review Drugs  1992 44:293-325  DOI:10.2165/00003495-199244030-00002  PMID:1382931
    • Arnold, A. Z., Topol, E. J. Assessment of reperfusion after thrombolytic therapy for myocardial-infarction American Heart Journal  1992 124:441-447  DOI:10.1016/0002-8703(92)90611-x  PMID:1636587
    • Muller, D. W. M., Topol, E. J., Abrams, G. D., Gallagher, K. P., Ellis, S. G. Intramural methotrexate therapy for the prevention of neointimal thickening after balloon angioplasty Journal of the American College of Cardiology  1992 20:460-466  PMID:1386089
    • Topol, E. J., Califf, R. M., Vandormael, M., Grines, C. L., George, B. S., Sanz, M. L., Wall, T., Obrien, M., Schwaiger, M., Aguirre, F. V., Young, S., Popma, J. J., et al. A randomized trial of late reperfusion therapy for acute myocardial infarction Circulation  1992 85:2090-2099  PMID:1591828
    • Popma, J. J., Topol, E. J., Hinohara, T., Pinkerton, C. A., Baim, D. S., King, S. B., Holmes, D. R., Whitlow, P. L., Kereiakes, D. J., Hartzler, G. O., Kent, K. M., Ellis, S. G., et al. Abrupt vessel closure after directional coronary atherectomy Journal of the American College of Cardiology  1992 19:1372-1379  PMID:1593028
    • Topol, E. J., Armstrong, P., Vandewerf, F., Kleiman, N., Lee, K., Morris, D., Simoons, M., Barbash, G., White, H., Califf, R. M. Confronting the issues of patient safety and investigator conflict-of-interest in an international clinical-trial of myocardial reperfusion Journal of the American College of Cardiology  1992 19:1123-1128  PMID:1564212
    • Lincofe, A. M., Popma, J. J., Ellis, S. G., Hacker, J. A., Topol, E. J. Abrupt vessel closure complicating coronary angioplasty - clinical, angiographic and therapeutic profile Journal of the American College of Cardiology  1992 19:926-935  PMID:1552113
    • Wall, T. C., Califf, R. M., George, B. S., Ellis, S. G., Samaha, J. K., Kereiakes, D. J., Worley, S. J., Sigmon, K., Topol, E. J. Accelerated plasminogen-activator dose regimens for coronary thrombolysis Journal of the American College of Cardiology  1992 19:482-489  PMID:1537998
    • Gacioch, G. M., Ellis, S. G., Lee, L., Bates, E. R., Kirsh, M., Walton, J. A., Topol, E. J. Cardiogenic-shock complicating acute myocardial-infarction - the use of coronary angioplasty and the integration of the new support devices into patient-management Journal of the American College of Cardiology  1992 19:647-653  PMID:1538023
    • Decesare, N. B., Popma, J. J., Holmes, D. R., Dick, R. J., Whitlow, P. L., King, S. B., Pinkerton, C. A., Kereiakes, D. J., Topol, E. J., Haudenschild, C. C., Ellis, S. G. Clinical angiographic and histologic correlates of ectasia after directional coronary atherectomy American Journal of Cardiology  1992 69:314-319  DOI:10.1016/0002-9149(92)90226-o  PMID:1734641
    • Muller, D. W. M., Ellis, S. G., Topol, E. J. Experimental-models of coronary-artery restenosis Journal of the American College of Cardiology  1992 19:418-432  PMID:1732371
    • Muller, D. W. M., Topol, E. J. Thrombolytic therapy - adjuvant mechanical intervention for acute myocardial-infarction American Journal of Cardiology  1992 69:A60-A70  DOI:10.1016/0002-9149(92)91172-z
    • Muller, D. W. M., Shamir, K. J., Ellis, S. G., Topol, E. J. Peripheral vascular complications after conventional and complex percutaneous coronary interventional procedures American Journal of Cardiology  1992 69:63-68  DOI:10.1016/0002-9149(92)90677-q  PMID:1729869
    • Kirshenbaum, J. M., Bahr, R. D., Flaherty, J. T., Gurewich, V., Levine, H. J., Loscalzo, J., Schumacher, R. R., Topol, E. J., Wahr, D. W., Braunwald, E. Clot-selective coronary thrombolysis with low-dose synergistic combinations of single-chain urokinase-type plasminogen-activator and recombinant tissue-type plasminogen-activator American Journal of Cardiology  1991 68:1564-1569  DOI:10.1016/0002-9149(91)90310-h  PMID:1746455
    • Ellis, S. G., Myler, R. K., King, S. B., Douglas, J. S., Topol, E. J., Shaw, R. E., Stertzer, S. H., Roubin, G. S., Murphy, M. C. Causes and correlates of death after unsupported coronary angioplasty - implications for use of angioplasty and advanced support techniques in high-risk settings American Journal of Cardiology  1991 68:1447-1451  DOI:10.1016/0002-9149(91)90277-r  PMID:1746425
    • Muller, D. W. M., Topol, E. J., Ellis, S. G., Woodlief, L. H., Sigmon, K. N., Kereiakes, D. J., George, B. S., Worley, S. J., Samaha, J. K., Phillips, H., Califf, R. M. Determinants of the need for early acute intervention in patients treated conservatively after thrombolytic therapy for acute myocardial-infarction Journal of the American College of Cardiology  1991 18:1594-1601  PMID:1960302
    • Popma, J. J., Decesare, N. B., Ellis, S. G., Holmes, D. R., Pinkerton, C. A., Whitlow, P., King, S. B., Ghazzal, Z. M. B., Topol, E. J., Garratt, K. N., Kereiakes, D. J. Clinical, angiographic and procedural correlates of quantitative coronary dimensions after directional coronary atherectomy Journal of the American College of Cardiology  1991 18:1183-1189  PMID:1918694
    • Topol, E. J. Which thrombolytic agent should one choose Progress in Cardiovascular Diseases  1991 34:165-178  DOI:10.1016/0033-0620(91)90011-a  PMID:1947122
    • Tenaglia, A. N., Califf, R. M., Candela, R. J., Kereiakes, D. J., Berrios, E., Young, S. Y., Stack, R. S., Topol, E. J. Thrombolytic therapy in patients requiring cardiopulmonary-resuscitation American Journal of Cardiology  1991 68:1015-1019  DOI:10.1016/0002-9149(91)90488-7  PMID:1927913
    • Lee, P. N. V., Muller, D. W. M., Popma, J. J., Ellis, S. G., Topol, E. J. A comparison of clinical and quantitative angiographic outcomes of coronary stenting in elective and emergency settings: a single center experience Coronary Artery Disease  1991 2:945-951
    • Dellborg, M., Topol, E. J., Swedberg, K. Dynamic qrs complex and st segment vectorcardiographic monitoring can identify vessel patency in patients with acute myocardial-infarction treated with reperfusion therapy American Heart Journal  1991 122:943-948  DOI:10.1016/0002-8703(91)90455-q  PMID:1927880
    • Dick, R. J., Popma, J. J., Muller, D. W. M., Burek, K. A., Topol, E. J. In-hospital costs associated with new percutaneous coronary devices American Journal of Cardiology  1991 68:879-885  DOI:10.1016/0002-9149(91)90403-8  PMID:1927947
    • Bates, E. R., Topol, E. J. Limitations of thrombolytic therapy for acute myocardial-infarction complicated by congestive-heart-failure and cardiogenic-shock Journal of the American College of Cardiology  1991 18:1077-1084  PMID:1894853
    • Topol, E. J. Integration of anticoagulation, thrombolysis and coronary angioplasty for unstable angina-pectoris American Journal of Cardiology  1991 68:B136-B141  DOI:10.1016/0002-9149(91)90396-3
    • Muller, D. W. M., Topol, E. J. Implantable devices in the coronary-artery - from metal to genes Trends in Cardiovascular Medicine  1991 1:225-232  DOI:10.1016/1050-1738(91)90026-b  PMID:21239300
    • Morris, J. A., Muller, D. W. M., Topol, E. J. Combination thrombolytic therapy - a comparison of simultaneous and sequential regimens of tissue plasminogen-activator and urokinase American Heart Journal  1991 122:375-380  DOI:10.1016/0002-8703(91)90988-t  PMID:1907086
    • Kereiakes, D. J., Califf, R. M., George, B. S., Ellis, S., Samaha, J., Stack, R., Martin, L. H., Young, S., Topol, E. J. Coronary-bypass surgery improves global and regional left-ventricular function following thrombolytic therapy for acute myocardial-infarction American Heart Journal  1991 122:390-399  DOI:10.1016/0002-8703(91)90991-p  PMID:1907087
    • Ellis, S. G., Decesare, N. B., Pinkerton, C. A., Whitlow, P., King, S. B., Ghazzal, Z. M. B., Kereiakes, D. J., Popma, J. J., Menke, K. K., Topol, E. J., Holmes, D. R. Relation of stenosis morphology and clinical presentation to the procedural results of directional coronary atherectomy Circulation  1991 84:644-653  PMID:1860208
    • Popma, J. J., Topol, E. J. Adjuncts to thrombolysis for myocardial reperfusion Annals of Internal Medicine  1991 115:34-44  PMID:1675557
    • Ellis, S. G., Cowley, M. J., Disciascio, G., Deligonul, U., Topol, E. J., Bulle, T. M., Vandormael, M. G. Determinants of 2-year outcome after coronary angioplasty in patients with multivessel disease on the basis of comprehensive preprocedural evaluation - implications for patient selection Circulation  1991 83:1905-1914  PMID:2040043
    • Topol, E. J., Holmes, D. R., Rogers, W. J. Coronary angiography after thrombolytic therapy for acute myocardial-infarction Annals of Internal Medicine  1991 114:877-885  PMID:2014950
    • Schatz, R. A., Goldberg, S., Leon, M., Baim, D., Hirshfeld, J., Cleman, M., Ellis, S., Topol, E. Clinical-experience with the palmaz-schatz coronary stent Journal of the American College of Cardiology  1991 17:B155-B159
    • Muller, D. W. M., Ellis, S. G., Topol, E. J. Colchicine and antineoplastic therapy for the prevention of restenosis after percutaneous coronary interventions Journal of the American College of Cardiology  1991 17:B126-B131
    • Califf, R. M., Topol, E. J., Stack, R. S., Ellis, S. G., George, B. S., Kereiakes, D. J., Samaha, J. K., Worley, S. J., Anderson, J. L., Harrelson-Woodlief, S. L., Wall, T. C., Phillips, H. R., et al. Evaluation of combination thrombolytic therapy and timing of cardiac-catheterization in acute myocardial-infarction - results of thrombolysis and angioplasty in myocardial-infarction phase-5 randomized trial Circulation  1991 83:1543-1556  PMID:1902405
    • Ellis, S. G., Bates, E. R., Schaible, T., Weisman, H. F., Pitt, B., Topol, E. J. Prospects for the use of antagonists to the platelet glycoprotein-IIb glycoprotein-IIIa receptor to prevent postangioplasty restenosis and thrombosis Journal of the American College of Cardiology  1991 17:B89-B95
    • Dick, R. J. L., Haudenschild, C. C., Popma, J. J., Ellis, S. G., Muller, D. W., Topol, E. J. Directional atherectomy for total coronary occlusions Coronary Artery Disease  1991 2:189-199  DOI:10.1097/00019501-199104000-00010
    • Mark, D. B., Sigmon, K., Topol, E. J., Kereiakes, D. J., Pryor, D. B., Candela, R. J., Califf, R. M. Identification of acute myocardial-infarction patients suitable for early hospital discharge after aggressive interventional therapy - results from the thrombolysis and angioplasty in acute myocardial-infarction registry Circulation  1991 83:1186-1193  PMID:2013140
    • Muller, D. W. M., Topol, E. J., Ellis, S. G., Sigmon, K. N., Lee, K., Califf, R. M. Multivessel coronary-artery disease - a key predictor of short-term prognosis after reperfusion therapy for acute myocardial-infarction American Heart Journal  1991 121:1042-1049  DOI:10.1016/0002-8703(91)90661-z  PMID:1901190
    • Sutton, J. M., Topol, E. J. Significance of a negative exercise thallium test in the presence of a critical residual stenosis after thrombolysis for acute myocardial-infarction Circulation  1991 83:1278-1286  PMID:1901529
    • Topol, E. J., Agnelli, G. Strategies for administration of tissue plasminogen-activator Molecular Biology & Medicine  1991 8:219-234  PMID:1806764
    • Stewart, R. E., Kander, N., Juni, J. E., Ellis, S. G., Oneill, W. W., Schork, A., Topol, E. J., Schwaiger, M. Submaximal exercise tl-201 spect for assessment of interventional therapy in patients with acute myocardial-infarction American Heart Journal  1991 121:1033-1041  DOI:10.1016/0002-8703(91)90660-a  PMID:1901189
    • Sane, D. C., Stump, D. C., Topol, E. J., Sigmon, K. N., Kereiakes, D. J., George, B. S., Mantell, S. J., Macy, E., Collen, D., Califf, R. M. Correlation between base-line plasminogen-activator inhibitor levels and clinical outcome during therapy with tissue plasminogen-activator for acute myocardial-infarction Thrombosis and Haemostasis  1991 65:275-279  PMID:1904653
    • Lincoff, A. M., Popma, J. J., Ellis, S. G., Vogel, R. A., Topol, E. J. Percutaneous support devices for high-risk or complicated coronary angioplasty Journal of the American College of Cardiology  1991 17:770-780  PMID:1993799
    • Ohman, E. M., Califf, R. M., George, B. S., Quigley, P. J., Kereiakes, D. J., Harrelson-Woodlief, S. L., Candela, R. J., Flanagan, C., Stack, R. S., Topol, E. J. The use of intraaortic balloon pumping as an adjunct to reperfusion therapy in acute myocardial-infarction American Heart Journal  1991 121:895-901  DOI:10.1016/0002-8703(91)90205-v  PMID:1900381
    • Ellis, S. G., Debowey, D., Bates, E. R., Topol, E. J. Treatment of recurrent ischemia after thrombolysis and successful reperfusion for acute myocardial-infarction - effect on in-hospital mortality and left-ventricular function Journal of the American College of Cardiology  1991 17:752-757  PMID:1993797
    • Popma, J. J., Dick, R. J. L., Haudenschild, C. C., Topol, E. J., Ellis, S. G. Atherectomy of right coronary ostial stenoses - initial and long-term results, technical features and histologic-findings American Journal of Cardiology  1991 67:431-434  DOI:10.1016/0002-9149(91)90057-r  PMID:1994670
    • Nabel, E. G., Topol, E. J., Galeana, A., Ellis, S. G., Bates, E. R., Werns, S. W., Walton, J. A., Muller, D. W., Schwaiger, M., Pitt, B. A randomized placebo-controlled trial of combined early intravenous captopril and recombinant tissue-type plasminogen-activator therapy in acute myocardial-infarction Journal of the American College of Cardiology  1991 17:467-473  PMID:1825097
    • Clemmensen, P., Bates, E. R., Califf, R. M., Hlatky, M. A., Aronson, L., George, B. S., Lee, K. L., Kereiakes, D. J., Gacioch, G., Berrios, E., Topol, E. J. Complete atrioventricular-block complicating inferior wall acute myocardial-infarction treated with reperfusion therapy American Journal of Cardiology  1991 67:225-230  DOI:10.1016/0002-9149(91)90550-5  PMID:1899319
    • Kereiakes, D. J., Topol, E. J., George, B. S., Stack, R. S., Abbottsmith, C. W., Ellis, S., Candela, R. J., Harrelson, L., Martin, L. H., Califf, R. M. Myocardial-infarction with minimal coronary atherosclerosis in the era of thrombolytic reperfusion Journal of the American College of Cardiology  1991 17:304-312  PMID:1899433
    • Schatz, R. A., Baim, D. S., Leon, M., Ellis, S. G., Goldberg, S., Hirshfeld, J. W., Cleman, M. W., Cabin, H. S., Walker, C., Stagg, J., Buchbinder, M., Teirstein, P. S., et al. Clinical-experience with the palmaz-schatz coronary stent - initial results of a multicenter study Circulation  1991 83:148-161  PMID:1984878
    • Sane, D. C., Stump, D. C., Topol, E. J., Sigmon, K. N., Clair, W. K., Kereiakes, D. J., George, B. S., Stoddard, M. F., Bates, E. R., Stack, R. S., Califf, R. M. Racial-differences in responses to thrombolytic therapy with recombinant tissue-type plasminogen-activator - increased fibrin(ogen)olysis in blacks Circulation  1991 83:170-175  PMID:1898641
    • Muller, D. W. M., Topol, E. J. Selection of patients with acute myocardial-infarction for thrombolytic therapy Annals of Internal Medicine  1990 113:949-960  PMID:2240919
    • Wall, T. C., Califf, R. M., Harrelson-Woodlief, S. L. ,, Mark, D. B., Honan, M., Abbotsmith, C. W., Candela, R., Berrios, E., Phillips, H. R., Topol, E. J. Usefulness of a pericardial friction rub after thrombolytic therapy during acute myocardial-infarction in predicting amount of myocardial damage American Journal of Cardiology  1990 66:1418-1421  DOI:10.1016/0002-9149(90)90526-7  PMID:2123603
    • Bates, E. R., Clemmensen, P. M., Califf, R. M., Gorman, L. E., Aronson, L. G., George, B. S., Kereiakes, D. J., Topol, E. J. Precordial st segment depression predicts a worse prognosis in inferior infarction despite reperfusion therapy Journal of the American College of Cardiology  1990 16:1538-1544  PMID:2123903
    • Topol, E. J. Can thrombolysis be improved? Hospital Formulary  1990 25:19-22
    • Topol, E. J., Wilson, V. E. Pivotal role of early and sustained infarct vessel patency in patients with acute myocardial-infarction Heart & Lung  1990 19:583-595  PMID:2228647
    • Muller, D. W. M., Ellis, S. G., Debowey, D. L., Topol, E. J. Quantitative angiographic comparison of the immediate success of coronary angioplasty, coronary atherectomy and endoluminal stenting American Journal of Cardiology  1990 66:938-942  DOI:10.1016/0002-9149(90)90929-u  PMID:2220616
    • Ellis, S. G., Topol, E. J. Results of percutaneous transluminal coronary angioplasty of high-risk angulated stenoses American Journal of Cardiology  1990 66:932-937  DOI:10.1016/0002-9149(90)90928-t  PMID:2220615
    • Muller, D. W. M., Topol, E. J., George, B. S., Kereiakes, D. J., Aronson, L. G., Lee, K. L., Abbottsmith, C. W., Ellis, S. G., Califf, R. M. 2-year outcome after angiographically documented myocardial reperfusion for acute coronary-occlusion American Journal of Cardiology  1990 66:796-801  DOI:10.1016/0002-9149(90)90354-4  PMID:2220575
    • Ellis, S. G., Vandormael, M. G., Cowley, M. J., Disciascio, G., Deligonul, U., Topol, E. J., Bulle, T. M. Coronary morphological and clinical determinants of procedural outcome with angioplasty for multivessel coronary-disease - implications for patient selection Circulation  1990 82:1193-1202  PMID:2401060
    • Abbottsmith, C. W., Topol, E. J., George, B. S., Stack, R. S., Kereiakes, D. J., Candela, R. J., Anderson, L. C., Harrelson-Woodlief, S. L. ,, Califf, R. M. Fate of patients with acute myocardial-infarction with patency of the infarct-related vessel achieved with successful thrombolysis versus rescue angioplasty Journal of the American College of Cardiology  1990 16:770-778  PMID:1698843
    • Ohman, E. M., Califf, R. M., Topol, E. J., Candela, R., Abbottsmith, C., Ellis, S., Sigmon, K. N., Kereiakes, D., George, B., Stack, R. Consequences of reocclusion after successful reperfusion therapy in acute myocardial-infarction Circulation  1990 82:781-791  PMID:2394002
    • Oconnor, C. M., Califf, R. M., Massey, E. W., Mark, D. B., Kereiakes, D. J., Candela, R. J., Abbottsmith, C., George, B., Stack, R. S., Aronson, L., Mantell, S., Topol, E. J. Stroke and acute myocardial-infarction in the thrombolytic era - clinical correlates and long-term prognosis Journal of the American College of Cardiology  1990 16:533-540  PMID:2117618
    • Popma, J. J., Topol, E. J. Accelerated, combined, and adjunctive thrombolytic strategies for acute myocardial-infarction Current Opinion in Cardiology  1990 5:482-489  DOI:10.1097/00001573-199008000-00017
    • George, B. S., Candela, R. J., Topol, E. J., Stack, R. S., Kereiakes, D. J., Abbottsmith, C. W., Masek, R., Pickel, A., Dillon, J., Harrelson, L., Califf, R. M. Brachial approach to emergency cardiac-catheterization during thrombolytic therapy for acute myocardial-infarction Catheterization and Cardiovascular Diagnosis  1990 20:221-226  DOI:10.1002/ccd.1810200402  PMID:2119888
    • Williams, D. O., Topol, E. J., Califf, R. M., Roberts, R., Mancini, G. B. J., Joelson, J. M., Ellis, S. G., Kleiman, N. S. Intravenous recombinant tissue-type plasminogen-activator in patients with unstable angina-pectoris - results of a placebo-controlled, randomized trial Circulation  1990 82:376-383  PMID:2115407
    • Samson, M., Sutton, J. M., Topol, E. J., Serruys, P. W. Coronary angioplasty in myocardial-infarction - where are we Annales de Cardiologie et d'Angéiologie  1990 39:371-377  PMID:2205155
    • Topol, E. J. Coronary angioplasty in myocardial infarction Hospital Practice  1990 25:73-76, 79  PMID:2109756
    • Kavanaugh, K. M., Topol, E. J. Acute intervention during myocardial-infarction in patients with prior coronary-bypass surgery American Journal of Cardiology  1990 65:924-926  DOI:10.1016/0002-9149(90)91440-h  PMID:2321545
    • Califf, R. M., Topol, E. J., George, B. S., Kereiakes, D. J., Aronson, L. G., Lee, K. L., Martin, L., Candela, R., Abbottsmith, C., Oneill, W. W., Pryor, D. B., Stack, R. S. One-year outcome after therapy with tissue plasminogen-activator - report from the thrombolysis and angioplasty in myocardial-infarction trial American Heart Journal  1990 119:777-785  DOI:10.1016/s0002-8703(05)80311-4  PMID:2108575
    • Sutton, J. M., Topol, E. J. Usefulness of coronary-artery angioplasty strategies in acute myocardial-infarction Canadian Journal of Cardiology  1990 6:111-122  PMID:2187576
    • Muller, D. W. M., Topol, E. J., Califf, R. M., Sigmon, K. N., Gorman, L., George, B. S., Kereiakes, D. J., Lee, K. L., Ellis, S. G. Relationship between antecedent angina-pectoris and short-term prognosis after thrombolytic therapy for acute myocardial-infarction American Heart Journal  1990 119:224-231  DOI:10.1016/s0002-8703(05)80008-0  PMID:2405608
    • Kander, N. H., Holland, K. J., Pitt, B., Topol, E. J. A randomized pilot trial of brief versus prolonged heparin after successful reperfusion in acute myocardial-infarction American Journal of Cardiology  1990 65:139-142  DOI:10.1016/0002-9149(90)90074-b  PMID:2404389
    • Popma, J. J., Topol, E. J. Factors influencing restenosis after coronary angioplasty American Journal of Medicine  1990 88:N16-N24
    • Vogel, R. A., Shawl, F., Tommaso, C., Oneill, W., Overlie, P., Otoole, J., Vandormael, M., Topol, E., Tabari, K. K., Vogel, J., Smith, S., Freedmann, R., et al. Initial report of the national-registry-of-elective-cardiopulmonary bypass supported coronary angioplasty Journal of the American College of Cardiology  1990 15:23-29  PMID:2404047
    • Ellis, S. G., Muller, D. W., Topol, E. J. Possible survival benefit from concomitant beta-antagonist but not calcium-antagonist therapy during reperfusion for acute myocardial-infarction American Journal of Cardiology  1990 66:125-128  DOI:10.1016/0002-9149(90)90574-k  PMID:1973588
    • Muller, D. W. M., Topol, E. J. Unresolved issues: late reperfusion, lytic failure, and reocclusion Coronary Artery Disease  1990 1:39-49  DOI:10.1097/00019501-199001000-00007
    • Sane, D. C., Califf, R. M., Topol, E. J., Stump, D. C., Mark, D. B., Greenberg, C. S. Bleeding during thrombolytic therapy for acute myocardial-infarction - mechanisms and management Annals of Internal Medicine  1989 111:1010-1022  PMID:2688504
    • Holmes, D. R., Topol, E. J. Reperfusion momentum - lessons from the randomized trials of immediate coronary angioplasty for myocardial-infarction Journal of the American College of Cardiology  1989 14:1572-1578  DOI:10.1016/0735-1097(89)90401-4  PMID:2809019
    • Burek, K. A., Kirscht, J., Topol, E. J. Exercise capacity in patients 3 days after acute, uncomplicated myocardial-infarction Heart & Lung  1989 18:575-582  PMID:2684916
    • Califf, R. M., Topol, E. J., Gersh, B. J. From myocardial salvage to patient salvage in acute myocardial-infarction - the role of reperfusion therapy Journal of the American College of Cardiology  1989 14:1382-1388  DOI:10.1016/0735-1097(89)90445-2  PMID:2681322
    • Stump, D. C., Califf, R. M., Topol, E. J., Sigmon, K., Thornton, D., Masek, R., Anderson, L., Collen, D. Pharmacodynamics of thrombolysis with recombinant tissue-type plasminogen-activator - correlation with characteristics of and clinical outcomes in patients with acute myocardial-infarction Circulation  1989 80:1222-1230  PMID:2509104
    • Ellis, S. G., Topol, E. J., George, B. S., Kereiakes, D. J., Debowey, D., Sigmon, K. N., Pickel, A., Lee, K. L., Califf, R. M. Recurrent ischemia without warning - analysis of risk-factors for in-hospital ischemic events following successful thrombolysis with intravenous tissue plasminogen-activator Circulation  1989 80:1159-1165  PMID:2509102
    • Gacioch, G. M., Topol, E. J. Sudden paradoxic clinical deterioration during angioplasty of the occluded right coronary-artery in acute myocardial-infarction Journal of the American College of Cardiology  1989 14:1202-1209  DOI:10.1016/0735-1097(89)90418-x  PMID:2808974
    • Chapekis, A. T., Burek, K., Topol, E. J. The cost-benefit ratio of acute intervention for myocardial-infarction - results of a prospective, matched pair analysis American Heart Journal  1989 118:878-882  DOI:10.1016/0002-8703(89)90217-2  PMID:2510487
    • Topol, E. J., Ellis, S. G., Califf, R. M., George, B. S., Stump, D. C., Bates, E. R., Nabel, E. G., Walton, J. A., Candela, R. J., Lee, K. L., Kline, E. M., Pitt, B. Combined tissue-type plasminogen-activator and prostacyclin therapy for acute myocardial-infarction Journal of the American College of Cardiology  1989 14:877-884  PMID:2477426
    • Ellis, S. G., Shaw, R. E., King, S. B., Myler, R. K., Topol, E. J. Restenosis after excellent angiographic angioplasty result for chronic total coronary-artery occlusion - implications for newer percutaneous revascularization devices American Journal of Cardiology  1989 64:667-668  DOI:10.1016/0002-9149(89)90500-6  PMID:2528903
    • Muller, D. W. M., Topol, E. J. Acute myocardial infarction: early and late percutaneous trans-luminal coronary angioplasty Current Opinion in Cardiology  1989 4:524-530  DOI:10.1097/00001573-198908000-00012
    • Kereiakes, D. J., Topol, E. J., George, B. S., Abbottsmith, C. W., Stack, R. S., Candela, R. J., Oneill, W. W., Anderson, L. C., Califf, R. M. Favorable early and long-term prognosis following coronary-bypass surgery therapy for myocardial-infarction - results of a multicenter trial American Heart Journal  1989 118:199-207  DOI:10.1016/0002-8703(89)90177-4  PMID:2526573
    • Kander, N. H., Oneill, W., Topol, E. J., Gallison, L., Mileski, R., Ellis, S. G. Long-term follow-up of patients treated with coronary angioplasty for acute myocardial-infarction American Heart Journal  1989 118:228-233  DOI:10.1016/0002-8703(89)90180-4  PMID:2526574
    • Grines, C. L., Topol, E. J., Califf, R. M., Stack, R. S., George, B. S., Kereiakes, D., Boswick, J. M., Kline, E., Oneill, W. W. Prognostic implications and predictors of enhanced regional wall motion of the noninfarct zone after thrombolysis and angioplasty therapy of acute myocardial-infarction Circulation  1989 80:245-253  PMID:2526697
    • Muller, D. W. M., Ellis, S. G., Topol, E. J. Atherectomy of the left main coronary-artery with percutaneous cardiopulmonary bypass support American Journal of Cardiology  1989 64:114-116  DOI:10.1016/0002-9149(89)90668-1  PMID:2787097
    • Bates, E. R., Topol, E. J. Early hospital discharge in the myocardial reperfusion era Clinical Cardiology  1989 12:65-70  PMID:2691143
    • Topol, E. J. Recombinant tissue plasminogen-activator - implications in therapy Seminars in Hematology  1989 26:25-31
    • Ellis, S. G., Oneill, W. W., Bates, E. R., Walton, J. A., Nabel, E. G., Werns, S. W., Topol, E. J. Implications for patient triage from survival and left-ventricular functional recovery analyses in 500 patients treated with coronary angioplasty for acute myocardial-infarction Journal of the American College of Cardiology  1989 13:1251-1259  PMID:2522954
    • Ellis, S. G., Topol, E. J. Intracoronary stents - will they fulfill their promise as an adjunct to angioplasty Journal of the American College of Cardiology  1989 13:1425-1430  PMID:2522960
    • Ellis, S. G., Shaw, R. E., Gershony, G., Thomas, R., Roubin, G. S., Douglas, J. S., Topol, E. J., Startzer, S. H., Myler, R. K., King, S. B. Risk-factors, time course and treatment effect for restenosis after successful percutaneous trans-luminal coronary angioplasty of chronic total occlusion American Journal of Cardiology  1989 63:897-901  DOI:10.1016/0002-9149(89)90135-5  PMID:2522727
    • Loscalzo, J., Wharton, T. P., Kirshenbaum, J. M., Levine, H. J., Flaherty, J. T., Topol, E. J., Ramaswamy, K., Kosowsky, B. D., Salem, D. N., Ganz, P., Brinker, J. A., Gurewich, V., et al. Clot-selective coronary thrombolysis with pro-urokinase Circulation  1989 79:776-782  PMID:2494004
    • Ellis, S. G., Oneill, W. W., Bates, E. R., Walton, J. A., Nabel, E. G., Topol, E. J. Coronary angioplasty as primary therapy for acute myocardial-infarction 6 to 48 hours after symptom onset - report of an initial experience Journal of the American College of Cardiology  1989 13:1122-1126  PMID:2522467
    • Holland, K. J., Oneill, W. W., Bates, E. R., Pitt, B., Topol, E. J. Emergency percutaneous trans-luminal coronary angioplasty during acute myocardial-infarction for patients more than 70 years of age American Journal of Cardiology  1989 63:399-403  DOI:10.1016/0002-9149(89)90307-x  PMID:2521765
    • Topol, E. J., George, B. S., Kereiakes, D. J., Stump, D. C., Candela, R. J., Abbottsmith, C. W., Aronson, L., Pickel, A., Boswick, J. M., Lee, K. L., Ellis, S. G., Califf, R. M. A randomized controlled trial of intravenous tissue plasminogen-activator and early intravenous heparin in acute myocardial-infarction Circulation  1989 79:281-286  PMID:2492454
    • Ellis, S. G., Gallison, L., Grines, C. L., Langburd, A. B., Bates, E. R., Walton, J. A., Oneill, W. W., Topol, E. J. Incidence and predictors of early recurrent ischemia after successful percutaneous trans-luminal coronary angioplasty for acute myocardial-infarction American Journal of Cardiology  1989 63:263-268  DOI:10.1016/0002-9149(89)90327-5  PMID:2521536
    • Nicklas, J. M., Topol, E. J., Kander, N., Oneill, W. W., Walton, J. A., Ellis, S. G., Gorman, L., Pitt, B. Randomized, double-blind, placebo-controlled trial of tissue plasminogen-activator in unstable angina Journal of the American College of Cardiology  1989 13:434-441  PMID:2492325
    • Bates, E. R., Califf, R. M., Stack, R. S., Aronson, L., George, B. S., Candela, R. J., Kereiakes, D. J., Abbottsmith, C. W., Anderson, L., Pitt, B., Oneill, W. W., Topol, E. J. Thrombolysis and angioplasty in myocardial-infarction (tami-1) trial - influence of infarct location on arterial patency, left-ventricular function and mortality Journal of the American College of Cardiology  1989 13:12-18  PMID:2521226
    • Topol, E. J. Coronary angioplasty for acute myocardial-infarction Annals of Internal Medicine  1988 109:970-978  PMID:2973762
    • Steinberg, E. P., Topol, E. J., Sakin, J. W., Kahane, S. N., Appel, L. J., Powe, N. R., Anderson, G. F., Erickson, J. E., Guerci, A. D. Cost and procedure implications of thrombolytic therapy for acute myocardial-infarction Journal of the American College of Cardiology  1988 12:A58-A68
    • Topol, E. J., Califf, R. M., George, B. S., Kereiakes, D. J., Lee, K. L. Insights derived from the thrombolysis and angioplasty in myocardial-infarction (tami) trials Journal of the American College of Cardiology  1988 12:A24-A31
    • Ellis, S. G., Topol, E. J., Gallison, L., Grines, C. L., Langburd, A. B., Bates, E. R., Walton, J. A., Oneill, W. W. Predictors of success for coronary angioplasty performed for acute myocardial-infarction Journal of the American College of Cardiology  1988 12:1407-1415  PMID:2973481
    • Carlson, S. E., Aldrich, M. S., Greenberg, H. S., Topol, E. J. Intracerebral hemorrhage complicating intravenous tissue plasminogen-activator treatment Archives of Neurology  1988 45:1070-1073  PMID:3140769
    • Grines, C. L., Oneill, W. W., Anselmo, E. G., Juni, J. E., Topol, E. J. Comparison of left-ventricular function and contractile reserve after successful recanalization by thrombolysis versus rescue percutaneous trans-luminal coronary angioplasty for acute myocardial-infarction American Journal of Cardiology  1988 62:352-357  DOI:10.1016/0002-9149(88)90957-5  PMID:2970774
    • Topol, E. J., Nicklas, J. M., Kander, N. H., Walton, J. A., Ellis, S. G., Gorman, L., Pitt, B. Coronary revascularization after intravenous tissue plasminogen-activator for unstable angina-pectoris - results of a randomized, double-blind, placebo-controlled trial American Journal of Cardiology  1988 62:368-371  DOI:10.1016/0002-9149(88)90960-5  PMID:2970776
    • Califf, R. M., Topol, E. J., George, B. S., Boswick, J. M., Abbottsmith, C., Sigmon, K. N., Candela, R., Masek, R., Kereiakes, D., Oneill, W. W., Stack, R. S., Stump, D. Hemorrhagic complications associated with the use of intravenous tissue plasminogen-activator in treatment of acute myocardial-infarction American Journal of Medicine  1988 85:353-359  DOI:10.1016/0002-9343(88)90586-4  PMID:3137818
    • Topol, E. J. An overview of the thrombolysis and angioplasty in acute myocardial infarction (TAMI) trials Archives Des Maladies Du Coeur Et Des Vaisseaux  1988 81:45-49  PMID:2973302
    • Califf, R. M., Topol, E. J., George, B. S., Boswick, J. M., Lee, K. L., Stump, D., Dillon, J., Abbottsmith, C., Candela, R. J., Kereiakes, D. J., Oneill, W. W., Stack, R. S. Characteristics and outcome of patients in whom reperfusion with intravenous tissue-type plasminogen-activator fails - results of the thrombolysis and angioplasty in myocardial-infarction (tami) i-trial Circulation  1988 77:1090-1099  PMID:2966016
    • Topol, E. J., Califf, R. M., George, B. S., Kereiakes, D. J., Rothbaum, D., Candela, R. J., Abbotsmith, C. W., Pinkerton, C. A., Stump, D. C., Collen, D., Lee, K. L., Pitt, B., et al. Coronary arterial thrombolysis with combined infusion of recombinant tissue-type plasminogen-activator and urokinase in patients with acute myocardial-infarction Circulation  1988 77:1100-1107  PMID:2966017
    • Kereiakes, D. J., Topol, E. J., George, B. S., Abbottsmith, C. W., Stack, R. S., Candela, R. J., Oneill, W. W., Martin, L. H., Califf, R. M. Emergency coronary-artery bypass-surgery preserves global and regional left-ventricular function after intravenous tissue plasminogen-activator therapy for acute myocardial-infarction Journal of the American College of Cardiology  1988 11:899-907  PMID:2965716
    • Califf, R. M., Oneil, W., Stack, R. S., Aronson, L., Mark, D. B., Mantell, S., George, B. S., Candela, R. J., Kereiakes, D. J., Abbottsmith, C., Topol, E. J. Failure of simple clinical measurements to predict perfusion status after intravenous thrombolysis Annals of Internal Medicine  1988 108:658-662  PMID:3128953
    • Topol, E. J., Burek, K., Oneill, W. W., Kewman, D. G., Kander, N. H., Shea, M. J., Schork, M. A., Kirscht, J., Juni, J. E., Pitt, B. A randomized controlled trial of hospital discharge 3 days after myocardial-infarction in the era of reperfusion New England Journal of Medicine  1988 318:1083-1088  DOI:10.1056/nejm198804283181702  PMID:3281014
    • Stump, D. C., Topol, E. J., Chen, A. B., Hopkins, A., Collen, D. Monitoring of hemostasis parameters during coronary thrombolysis with recombinant tissue-type plasminogen-activator Thrombosis and Haemostasis  1988 59:133-137  PMID:2455358
    • Topol, E. J., George, B. S., Kereiakes, D. J., Candela, R. J., Abbottsmith, C. W., Stump, D. C., Boswick, J. M., Stack, R. S., Califf, R. M. Comparison of 2 dose regimens of intravenous tissue plasminogen-activator for acute myocardial-infarction American Journal of Cardiology  1988 61:723-728  DOI:10.1016/0002-9149(88)91055-7  PMID:2965504
    • Humphrey, L. S., Topol, E. J., Rosenfeld, G. I., Borkon, A. M., Baumgartner, W. A., Gardner, T. J., Maruschak, G., Weiss, J. L. Immediate enhancement of left-ventricular relaxation by coronary-artery bypass-grafting - intraoperative assessment Circulation  1988 77:886-896  PMID:3258195
    • Grines, C. L., Topol, E. J., Bates, E. R., Juni, J. E., Walton, J. A., Oneill, W. W. Infarct vessel status after intravenous tissue plasminogen-activator and acute coronary angioplasty - prediction of clinical outcome American Heart Journal  1988 115:1-7  DOI:10.1016/0002-8703(88)90510-8  PMID:2962478
    • Oneill, W. W., Topol, E. J., Pitt, B. Reperfusion therapy of acute myocardial-infarction Progress in Cardiovascular Diseases  1988 30:235-266  DOI:10.1016/0033-0620(88)90018-7  PMID:3275989
    • Guerci, A. D., Gerstenblith, G., Brinker, J. A., Chandra, N. C., Gottlieb, S. O., Bahr, R. D., Weiss, J. L., Shapiro, E. P., Flaherty, J. T., Bush, D. E., Chew, P. H., Gottlieb, S. H., et al. A randomized trial of intravenous tissue plasminogen-activator for acute myocardial-infarction with subsequent randomization to elective coronary angioplasty New England Journal of Medicine  1987 317:1613-1618  DOI:10.1056/nejm198712243172601  PMID:2960897
    • Topol, E. J., Bates, E. R., Walton, J. A., Baumann, G., Wolfe, S., Maino, J., Bayer, L., Gorman, L., Kline, E. M., Oneill, W. W., Pitt, B. Community-hospital administration of intravenous tissue plasminogen-activator in acute myocardial-infarction - improved timing, thrombolytic efficacy and ventricular-function Journal of the American College of Cardiology  1987 10:1173-1177  PMID:3119685
    • Topol, E. J. Acute intervention for myocardial-infarction Chest  1987 92:929-932  DOI:10.1378/chest.92.5.929  PMID:2959455
    • Topol, E. J. Clinical use of streptokinase and urokinase therapy for acute myocardial-infarction Heart & Lung  1987 16:760-774  PMID:3316129
    • Topol, E. J., Juni, J. E., Oneill, W. W., Nicklas, J. M., Shea, M. J., Burek, K., Pitt, B. Exercise testing 3 days after onset of acute myocardial-infarction American Journal of Cardiology  1987 60:958-962  DOI:10.1016/0002-9149(87)90332-8  PMID:2960230
    • Topol, E. J., Califf, R. M., Kereiakes, D. J., George, B. S. Thrombolysis and angioplasty in myocardial-infarction (tami) trial Journal of the American College of Cardiology  1987 10:B65-B74
    • Topol, E. J. Advances in thrombolytic therapy for acute myocardial-infarction Journal of Clinical Pharmacology  1987 27:735-745  PMID:3123526
    • Topol, E. J., Califf, R. M., George, B. S., Kereiakes, D. J., Abbottsmith, C. W., Candela, R. J., Lee, K. L., Pitt, B., Stack, R. S., Oneill, W. W. A randomized trial of immediate versus delayed elective angioplasty after intravenous tissue plasminogen-activator in acute myocardial-infarction New England Journal of Medicine  1987 317:581-588  DOI:10.1056/nejm198709033171001  PMID:2956516
    • Papadopoulos, S. M., Chandler, W. F., Salamat, M. S., Topol, E. J., Sackellares, J. C. Recombinant human tissue-type plasminogen-activator therapy in acute thromboembolic stroke Journal of Neurosurgery  1987 67:394-398  DOI:10.3171/jns.1987.67.3.0394  PMID:3112328
    • Oneill, W. W., Topol, E. J., Fung, A., Bourdillon, P. D. V., Nicklas, J. M., Walton, J., Bates, E. R., Pitt, B. Coronary angioplasty as therapy for acute myocardial infarction: University of Michigan experience Circulation  1987 76:79-87  PMID:2955959
    • Bates, E. R., Topol, E. J., Kline, E. M., Langburd, A. B., Fung, A. Y., Walton, J. A., Bourdillon, P. D. V., Vogel, R. A., Pitt, B., Oneill, W. W. Early reperfusion therapy improves left-ventricular function after acute inferior myocardial-infarction associated with right coronary-artery disease American Heart Journal  1987 114:261-267  DOI:10.1016/0002-8703(87)90488-1  PMID:2955688
    • Sanz, M. L., Mancini, J., Lefree, M. T., Mickelson, J. K., Starling, M. R., Vogel, R. A., Topol, E. J. Variability of quantitative digital subtraction coronary angiography before and after percutaneous trans-luminal coronary angioplasty American Journal of Cardiology  1987 60:55-60  DOI:10.1016/0002-9149(87)90984-2  PMID:2955693
    • Topol, E. J., Morris, D. C., Smalling, R. W., Schumacher, R. R., Taylor, C. R., Nishikawa, A., Liberman, H. A., Collen, D., Tufte, M. E., Grossbard, E. B., Oneill, W. W. A multicenter, randomized, placebo-controlled trial of a new form of intravenous recombinant tissue-type plasminogen-activator (activase) in acute myocardial-infarction Journal of the American College of Cardiology  1987 9:1205-1213  PMID:2953770
    • Wind, B. E., Snider, A. R., Buda, A. J., Oneill, W. W., Topol, E. J., Dilworth, L. R. Pulsed doppler assessment of left-ventricular diastolic filling in coronary-artery disease before and immediately after coronary angioplasty American Journal of Cardiology  1987 59:1041-1046  DOI:10.1016/0002-9149(87)90845-9  PMID:2953227
    • Kircher, B. J., Topol, E. J., Oneill, W. W., Pitt, B. Prediction of infarct coronary-artery recanalization after intravenous thrombolytic therapy American Journal of Cardiology  1987 59:513-515  DOI:10.1016/0002-9149(87)91158-1  PMID:3825886
    • Walsh, D. G., Kaplan, L. R., Burney, R. E., Topol, E. J., Oneill, W. W. Use of tissue plasminogen-activator in the emergency department for acute myocardial-infarction Annals of Emergency Medicine  1987 16:243-247  DOI:10.1016/s0196-0644(87)80166-x  PMID:2949679
    • Topol, E. J., Oneill, W. W., Langburd, A. B., Walton, J. A., Bourdillon, P. D. V., Bates, E. R., Grines, C. L., Schork, A. M., Kline, E., Pitt, B. A randomized, placebo-controlled trial of intravenous recombinant tissue-type plasminogen-activator and emergency coronary angioplasty in patients with acute myocardial-infarction Circulation  1987 75:420-428  PMID:2948735
    • Topol, E. J., Ellis, S. G., Fishman, J., Leimgruber, P., Myler, R. K., Stertzer, S. H., Oneill, W. W., Douglas, J. S., Roubin, G. S., King, S. B. Multicenter study of percutaneous trans-luminal angioplasty for right coronary-artery ostial stenosis Journal of the American College of Cardiology  1987 9:1214-1218  PMID:2953771
    • Myler, R. K., Topol, E. J., Shaw, R. E., Stertzer, S. H., Clark, D. A., Fishman, J., Murphy, M. C. Multiple vessel coronary angioplasty - classification, results, and patterns of restenosis in 494 consecutive patients Catheterization and Cardiovascular Diagnosis  1987 13:1-15  DOI:10.1002/ccd.1810130102  PMID:2949849
    • Fung, A. Y., Lai, P., Topol, E. J., Bates, E. R., Bourdillon, P. D. V., Walton, J. A.