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  • Lester-Coll, N. H., Topol, E. J. Radiation oncology 2.0 Lancet  2021 398:654-654  PMID:34419194
  • Burioni, R., Topol, E. J. Has SARS-CoV-2 reached peak fitness? Nature Medicine  2021 27:1323-1324  DOI:10.1038/s41591-021-01421-7  PMID:34155413
  • Pandey, A. C., Golbus, J. R., Topol, E. J. Cardiac rehabilitation in the digital era Lancet  2021 398:16-16  PMID:34217385
  • Obermeyer, Z., Topol, E. J. Artificial intelligence, bias, and patients' perspectives Lancet  2021 397:2038-2038  PMID:34062138
  • Keane, P. A., Topol, E. J. AI-facilitated health care requires education of clinicians Lancet  2021 397:1254-1254  PMID:33812482
  • Burioni, R., Topol, E. J. Assessing the human immune response to SARS-CoV-2 variants Nature Medicine  2021 27:571-572  DOI:10.1038/s41591-021-01290-0  PMID:33649495
  • Gibbons, G. H., Seidman, C. E., Topol, E. J. Conquering Atherosclerotic Cardiovascular Disease-50 Years of Progress New England Journal of Medicine  2021 384:785-788  DOI:10.1056/NEJMp2033115  PMID:33657686
  • Topol, E. J. What's lurking in your electrocardiogram? Lancet  2021 397:785-785  PMID:33640054
  • Oran, D. P., Topol, E. J. Prevalence of Asymptomatic SARS-CoV-2 Infection RESPONSE Annals of Internal Medicine  2021 174:286-287  DOI:10.7326/l20-1285  PMID:33587872
  • Burton, D. R., Topol, E. J. Variant-proof vaccines - invest now for the next pandemic Nature  2021 590:386-388  DOI:10.1038/d41586-021-00340-4  PMID:33558746
  • Oran, D. P., Topol, E. J. The Proportion of SARS-CoV-2 Infections That Are Asymptomatic A Systematic Review Annals of Internal Medicine  2021 174:655-662  DOI:10.7326/m20-6976  PMID:33481642  PMCID:PMC7839426
  • Topol, E. J. Messenger RNA vaccines against SARS-CoV-2 Cell  2021 184:1401-1401  DOI:10.1016/j.cell.2020.12.039  PMID:33740443  PMCID:PMC7805392
  • Esteva, A., Chou, K., Yeung, S., Naik, N., Madani, A., Mottaghi, A., Liu, Y., Topol, E., Dean, J., Socher, R. Deep learning-enabled medical computer vision NPJ Digital Medicine  2021 4  DOI:10.1038/s41746-020-00376-2  PMID:33420381  PMCID:PMC7794558
  • Piech, C., Malik, A., Topol, E. J. Digitising the vision test Lancet  2021 398:1296-1296  DOI:10.1126/science.abc4226  PMID:34627485
  • Burton, D. R., Topol, E. J. Toward superhuman SARS-CoV-2 immunity? Nature Medicine  2021 27:5-6  DOI:10.1038/s41591-020-01180-x  PMID:33257892
  • Topol, E. J. Is my cough COVID-19? Lancet  2020 396:1874-1874  DOI:10.1016/s0140-6736(20)32589-7  PMID:33308459  PMCID:PMC7836626
  • Jaiswal, S. J., Quer, G., Galarnyk, M., Steinhubl, S. R., Topol, E. J., Owens, R. L. Association of Sleep Duration and Variability With Body Mass Index Sleep Measurements in a Large US Population of Wearable Sensor Users JAMA Internal Medicine  2020  DOI:10.1001/jamainternmed.2020.2834  PMID:32926073  PMCID:PMC7490746
  • Harvey, H., Topol, E. J. More than meets the AI: refining image acquisition and resolution Lancet  2020 396:1479-1479  PMID:33160557
  • Quer, G., Radin, J. M., Gadaleta, M., Baca-Motes, K., Ariniello, L., Ramos, E., Kheterpal, V., Topol, E. J., Steinhubl, S. R. Wearable sensor data and self-reported symptoms for COVID-19 detection Nature Medicine  2020 27:73-77  DOI:10.1038/s41591-020-1123-x  PMID:33122860
  • Verghese, A., Topol, E. Courage in a climate of fear Science Translational Medicine  2020 12  DOI:10.1126/scitranslmed.abf2461  PMID:33077677
  • Angrist, M., Barrangou, R., Baylis, F., Brokowski, C., Burgio, G., Caplan, A., Chapman, C. R., Church, G. M., Cook-Deegan, R., Cwik, B., Doudna, J. A., Evans, J. H., et al. Reactions to the National Academies/Royal Society Report on Heritable Human Genome Editing Crispr Journal  2020 3:332-349  DOI:10.1089/crispr.2020.29106.man  PMID:33095048
  • Topol, E. J. COVID-19 can affect the heart Science  2020 370:408-409  DOI:10.1126/science.abe2813  PMID:32967937
  • Muse, E. D., Topol, E. J. Digital medicine Guiding ultrasound image capture with artificial intelligence Lancet  2020 396:749-749  PMID:32919501
  • Norgeot, B., Quer, G., Beaulieu-Jones, B. K., Torkamani, A., Dias, R., Gianfrancesco, M., Arnaout, R., Kohane, I. S., Saria, S., Topol, E., Obermeyer, Z., Yu, B., et al. Minimum information about clinical artificial intelligence modeling: the MI-CLAIM checklist Nature Medicine  2020 26:1320-1324  DOI:10.1038/s41591-020-1041-y  PMID:32908275  PMCID:PMC7538196
  • Topol, E. J. Welcoming new guidelines for AI clinical research Nature Medicine  2020 26:1318-1320  DOI:10.1038/s41591-020-1042-x  PMID:32908274
  • Topol, E. Which Country Has the World's Best Health Care? Nature  2020 582:331-333
  • Oran, D. P., Topol, E. J. Prevalence of Asymptomatic SARS-CoV-2 Infection A Narrative Review Annals of Internal Medicine  2020 173:362-367  DOI:10.7326/m20-3012  PMID:32491919  PMCID:PMC7281624
  • Milstein, A., Topol, E. J. Computer vision's potential to improve health care Lancet  2020 395:1537-1537  DOI:10.1016/s0140-6736(20)31090-4  PMID:32416778
  • Kanchan, K., Iyer, K., Yanek, L. R., Carcamo-Orive, I., Taub, M. A., Malley, C., Baldwin, K., Becker, L. C., Broeckel, U., Cheng, L. Z., Cowan, C., D'Antonio, M., et al. Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program Stem Cell Research  2020 46  DOI:10.1016/j.scr.2020.101803  PMID:32442913
  • Keane, P. A., Topol, E. J. Digital medicine Medicine and meteorology: Cloud, connectivity, and care Lancet  2020 395:1334-1334  PMID:32334694
  • Nagendran, M., Chen, Y., Lovejoy, C. A., Gordon, A. C., Komorowski, M., Harvey, H., Topol, E. J., Ioannidis, J. P. A., Collins, G. S., Maruthappu, M. Artificial intelligence versus clinicians: systematic review of design, reporting standards, and claims of deep learning studies BMJ-British Medical Journal  2020 368  DOI:10.1136/bmj.m689  PMID:32213531  PMCID:PMC7190037
  • Dorsey, E. R., Topol, E. J. Telemedicine 2020 and the next decade Lancet  2020 395:859-859  PMID:32171399
  • Berzin, T. M., Topol, E. J. Adding artificial intelligence to gastrointestinal endoscopy Lancet  2020 395:485-485  PMID:32061286
  • Quer, G., Gouda, P., Galarnyk, M., Topol, E. J., Steinhubl, S. R. Inter- and intraindividual variability in daily resting heart rate and its associations with age, sex, sleep, BMI, and time of year: Retrospective, longitudinal cohort study of 92,457 adults PLoS One  2020 15  DOI:10.1371/journal.pone.0227709  PMID:32023264  PMCID:PMC7001906
  • Muse, E. D., Topol, E. J. A brighter future for kidney disease? Lancet  2020 395:179-179  PMID:31954451
  • Salfati, E. L., Spencer, E. G., Topol, S. E., Muse, E. D., Rueda, M., Lucas, J. R., Wagner, G. N., Campman, S., Topol, E. J., Torkamani, A. Re-analysis of whole-exome sequencing data uncovers novel diagnostic variants and improves molecular diagnostic yields for sudden death and idiopathic diseases Genome Medicine  2019 11  DOI:10.1186/s13073-019-0702-2  PMID:31847883  PMCID:PMC6916453
  • Keane, P., Topol, E. Digital medicine Reinventing the eye exam Lancet  2019 394:2141-2141
  • Regev, A., Zhang, F., Jaffee, E., Farrar, J., Nkengasong, J., Topol, E., Partridge, L., Mundel, T., Tabernero, J., Sabeti, P., Toreele, E. Looking forward 25 years: the future of medicine Nature Medicine  2019 25:1804-1807  DOI:10.1038/s41591-019-0693-y  PMID:31806889
  • Esteva, A., Topol, E. Can skin cancer diagnosis be transformed by AI? Lancet  2019 394:1795-1795
  • Chan, J., Raju, S. C., Topol, E. Towards a tricorder for diagnosing paediatric conditions Lancet  2019 394:907-907  DOI:10.1016/s0140-6736(19)32087-2
  • Muse, E. D., Topol, E. J. Digital orthodoxy of human data collection Lancet  2019 394:556-556  PMID:31423988
  • Topol, E. J. Everybody wants to go to heaven but nobody wants to die: bioethics and the transformation of health care in america Nature  2019 572:308-309  DOI:10.1038/d41586-019-02412-y
  • Pandey, A. C., Topol, E. J. Dispense with supplements for improving heart outcomes Annals of Internal Medicine  2019 171:216-217  DOI:10.7326/m19-1498  PMID:31284306
  • Topol, E. J. Deep learning detects impending organ injury Nature  2019 572:36-37  DOI:10.1038/d41586-019-02308-x  PMID:31367025
  • Topol, E., Lee, K. F. It takes a planet Nature Biotechnology  2019 37:858-861  DOI:10.1038/s41587-019-0214-z  PMID:31375799
  • Oran, D. P., Topol, E. J. Digital medicine The rise of the virtualist Lancet  2019 394:17-17  DOI:10.1377/hblog20180319.150005
  • Topol, E. Man and machine medicine Scientist  2019 33:61-61
  • Topol, E. J. A decade of digital medicine innovation Science Translational Medicine  2019 11  DOI:10.1126/scitranslmed.aaw7610  PMID:31243153
  • Torkamani, A., Topol, E. Polygenic risk scores expand to obesity Cell  2019 177:518-520  DOI:10.1016/j.cell.2019.03.051  PMID:31002792
  • Waalen, J., Peters, M., Ranamukhaarachchi, D., Li, J., Ebner, G., Senkowsky, J., Topol, E. J., Steinhubl, S. R. Real world usage characteristics of a novel mobile health self-monitoring device: Results from the Scanadu Consumer Health Outcomes (SCOUT) Study PLoS One  2019 14  DOI:10.1371/journal.pone.0215468  PMID:30990860  PMCID:PMC6467418
  • Evangelista, L., Steinhubl, S. R., Topol, E. J. Digital health care for older adults Lancet  2019 393:1493-1493  DOI:10.1016/s0140-6736(19)30800-1  PMID:30983579
  • Jaiswal, S. J., Topol, E. J., Steinhubl, S. R. Digitising the way to better sleep health Lancet  2019 393:639-639  DOI:10.1001/jamapsychiatry.2018.2745  PMID:30782334
  • Ensign, S. F., Baca-Motes, K., Steinhubl, S. R., Topol, E. J. Characteristics of the modern-day physician house call Medicine  2019 98  DOI:10.1097/md.0000000000014671  PMID:30813215  PMCID:PMC6408061
  • Kumar, A., Thomas, S. K., Wong, K. C., Lo Sardo, V., Cheah, D. S., Hou, Y. H., Placone, J. K., Tenerelli, K. P., Ferguson, W. C., Torkamani, A., Topol, E. J., Baldwin, K. K., et al. Mechanical activation of noncoding-RNA-mediated regulation of disease-associated phenotypes in human cardiomyocytes Nature Biomedical Engineering  2019 3:137-146  DOI:10.1038/s41551-018-0344-5
  • Hamideh, D., Arellano, B., Topol, E. J., Steinhubl, S. R. Your digital nutritionist Lancet  2019 393:19-19  DOI:10.1016/s0140-6736(18)33170-2  PMID:30614448
  • Spencer, E. G., Topol, E. J. Direct to consumer fitness DNA testing Clinical Chemistry  2019 65:45-47  DOI:10.1373/clinchem.2018.287326  PMID:30274978
  • Topol, E. J. High-performance medicine: the convergence of human and artificial intelligence Nature Medicine  2019 25:44-56  DOI:10.1038/s41591-018-0300-7  PMID:30617339
  • Wineinger, N. E., Barrett, P. M., Zhang, Y., Irfanullah, I., Muse, E. D., Steinhubl, S. R., Topol, E. J. Identification of paroxysmal atrial fibrillation subtypes in over 13,000 individuals Heart Rhythm  2019 16:26-30  DOI:10.1016/j.hrthm.2018.08.012  PMID:30118885
  • Lo Sardo, V., Chubukov, P., Ferguson, W., Kumar, A., Teng, E. L., Duran, M., Zhang, L., Cost, G., Engler, A. J., Urnov, F., Topol, E. J., Torkamani, A., et al. Unveiling the role of the most impactful cardiovascular risk locus through haplotype editing Cell  2018 175:1796-1810  DOI:10.1016/j.cell.2018.11.014  PMID:30528432
  • Tarassenko, L., Topol, E. J. Monitoring jet engines and the health of people JAMA-Journal of the American Medical Association  2018 320:2309-2310  DOI:10.1001/jama.2018.16558  PMID:30453330
  • Wang, F., Wang, I. Z., Ellis, S., Archacki, S., Barnard, J., Hubbard, C., Topol, E. J., Chen, Q., Wang, Q. K. Analysis of causal effect of APOA5 variants on premature coronary artery disease Annals of Human Genetics  2018 82:437-447  DOI:10.1111/ahg.12273  PMID:30024021  PMCID:PMC6188800
  • Torkamani, A., Topol, E. Your genome, on demand MIT Technology Review  2018 121:20-21
  • Radin, J. M., Topol, E. J., Steinhubl, S. R. A digital toolkit for improved maternal health Lancet  2018 392:1107-1107  DOI:10.1016/s0140-6736(18)32294-3
  • Steinhubl, S. R., Topol, E. J. A skin patch for sensing blood pressures Nature Biomedical Engineering  2018 2:633-634  DOI:10.1038/s41551-018-0296-9
  • Quer, G., Nikzad, N., Chieh, A., Normand, A., Vegreville, M., Topol, E. J., Steinhubl, S. R. Home monitoring of blood pressure: short-term changes during serial measurements for 56398 subjects Ieee Journal of Biomedical and Health Informatics  2018 22:1691-1698  DOI:10.1109/jbhi.2017.2776946  PMID:29989995  PMCID:PMC6053341
  • Torkamani, A., Wineinger, N. E., Topol, E. J. The personal and clinical utility of polygenic risk scores Nature Reviews Genetics  2018 19:581-590  DOI:10.1038/s41576-018-0018-x  PMID:29789686
  • Steinhubl, S. R., Topol, E. J. Now we're talking: bringing a voice to digital medicine Lancet  2018 392:627-627
  • Modena, B. D., Bellahsen, O., Nikzad, N., Chieh, A., Parikh, N., Dufek, D. M., Ebner, G., Topol, E. J., Steinhubl, S. Advanced and accurate mobile health tracking devices record new cardiac vital signs Hypertension  2018 72:503-510  DOI:10.1161/hypertensionaha.118.11177  PMID:29967036  PMCID:PMC6044460
  • Song, M. Y., Steinhubl, S. R., Topol, E. J. Digital medicine: The beginning of the end of fingersticks? Lancet  2018 392:203-203  DOI:10.1016/s0140-6736(18)31576-9
  • Steinhubl, S. R., Waalen, J., Edwards, A. M., Ariniello, L. M., Mehta, R. R., Ebner, G. S., Carter, C., Baca-Motes, K., Felicione, E., Sarich, T., Topol, E. J. Effect of a home-based wearable continuous ECG monitoring patch on detection of undiagnosed atrial fibrillation the mSToPS randomized clinical trial JAMA-Journal of the American Medical Association  2018 320:146-155  DOI:10.1001/jama.2018.8102  PMID:29998336
  • Muse, E. D., Torkamani, A., Topol, E. J. When genomics goes digital Lancet  2018 391:2405-2405  DOI:10.1038/s41576-018-0018-x  PMID:29916375
  • Topol, E. Bad blood secrets and lies in a Silicon Valley startup Nature  2018 557:306-307
  • Kim, K. I., Nikzad, N., Quer, G., Wineinger, N. E., Vegreville, M., Normand, A., Schmidt, N., Topol, E. J., Steinhubl, S. Real world home blood pressure variability in over 56,000 individuals with nearly 17 million measurements American Journal of Hypertension  2018 31:566-573  DOI:10.1093/ajh/hpx221  PMID:29365036  PMCID:PMC5905665
  • Telenti, A., Steinhubl, S. R., Topol, E. J. Rethinking the medical record Lancet  2018 391:1013-1013  PMID:29565009
  • Mikk, K. A., Sleeper, H. A., Topol, E. Patient data ownership reply JAMA-Journal of the American Medical Association  2018 319:935-936  DOI:10.1001/jama.2017.21688  PMID:29509862
  • Jha, S., Topol, E. J. Information and artificial intelligence Journal of the American College of Radiology  2018 15:509-511  DOI:10.1016/j.jacr.2017.12.025
  • Steinhubl, S. R., Kim, K. I., Ajayi, T., Topol, E. J. Virtual care for improved global health Lancet  2018 391:419-419  PMID:29407024
  • Dharajiya, N. G., Grosu, D. S., Farkas, D. H., McCullough, R. M., Almasri, E., Sun, Y., Kim, S. K., Jensen, T. J., Saldivar, J. S., Topol, E. J., van den Boom, D., Ehrich, M. Incidental detection of maternal neoplasia in noninvasive prenatal testing Clinical Chemistry  2018 64:329-335  DOI:10.1373/clinchem.2017.277517  PMID:28982650
  • Muse, E. D., Wineinger, N. E., Spencer, E. G., Peters, M., Henderson, R., Zhang, Y., Barrett, P. M., Rivera, S. P., Wohlgemuth, J. G., Devlin, J. J., Shiffman, D., Topol, E. J. Validation of a genetic risk score for atrial fibrillation: A prospective multicenter cohort study PLoS Medicine  2018 15  DOI:10.1371/journal.pmed.1002525  PMID:29534064  PMCID:PMC5849279
  • Bansal, V., Gassenhuber, J., Phillips, T., Oliveira, G., Harbaugh, R., Villarasa, N., Topol, E. J., Seufferlein, T., Boehm, B. O. Spectrum of mutations in monogenic diabetes genes identified from high-throughput DNA sequencing of 6888 individuals BMC Medicine  2017 15  DOI:10.1186/s12916-017-0977-3  PMID:29207974  PMCID:PMC5717832
  • Steinhubl, S. R., McGovern, P., Dylan, J., Topol, E. J. The digitised clinical trial Lancet  2017 390:2135-2135  PMID:29143747
  • Mikk, K. A., Sleeper, H. A., Topol, E. J. The pathway to patient data ownership and better health JAMA-Journal of the American Medical Association  2017 318:1433-1434  DOI:10.1001/jama.2017.12145  PMID:28973063
  • Muse, E. D., Kramer, E. R., Wang, H. Y., Barrett, P., Parviz, F., Novotny, M. A., Lasken, R. S., Jatkoe, T. A., Oliveira, G., Peng, H. F., Lu, J., Connelly, M. C., et al. A whole blood molecular signature for acute myocardial infarction Scientific Reports  2017 7  DOI:10.1038/s41598-017-12166-0  PMID:28947747  PMCID:PMC5612952
  • Torkamani, A., Andersen, K. G., Steinhubl, S. R., Topol, E. J. High-Definition Medicine Cell  2017 170:828-843  DOI:10.1016/j.cell.2017.08.007  PMID:28841416
  • Quer, G., Muse, E. D., Nikzad, N., Topol, E. J., Steinhubl, S. R. Digital medicine: Augmenting diagnostic vision with AI Lancet  2017 390:221-221
  • Barrett, P. M., Steinhubl, S. R., Muse, E. D., Topol, E. J. Digitising the mind Lancet  2017 389:1877-1877  PMID:28513442
  • Muse, E. D., Barrett, P. M., Steinhubl, S. R., Topol, E. J. Towards a smart medical home Lancet  2017 389:358-358  PMID:28137686
  • Topol, E. J. Is there an ICD-10 code for hyperbole? JAMA-Journal of the American Medical Association  2017 317:10-11  PMID:28030677
  • Guo, Y., Wang, F., Li, L., Gao, H., Arckacki, S., Wang, I. Z., Barnard, J., Ellis, S., Hubbard, C., Topol, E. J., Chen, Q., Wang, Q. K. Genome-wide linkage analysis of large multiple multigenerational families identifies novel genetic loci for coronary rrtery disease Scientific Reports  2017 7  DOI:10.1038/s41598-017-05381-2  PMID:28710368  PMCID:PMC5511258
  • Lo Sardo, V., Ferguson, W., Erikson, G. A., Topol, E. J., Baldwin, K. K., Torkamani, A. Influence of donor age on induced pluripotent stem cells Nature Biotechnology  2017 35:69-74  DOI:10.1038/nbt.3749  PMID:27941802
  • Jha, S., Topol, E. J. Adapting to artificial intelligence radiologists and pathologists as information specialists JAMA-Journal of the American Medical Association  2016 316:2353-2354  DOI:10.1001/jama.2016.17438  PMID:27898975
  • Kim, J. Y., Wineinger, N. E., Taitel, M., Radin, J. M., Akinbosoye, O., Jiang, J., Nikzad, N., Orr, G., Topol, E., Steinhubl, S. Self-monitoring utilization patterns among individuals in an incentivized program for healthy behaviors Journal of Medical Internet Research  2016 18:83-97  DOI:10.2196/jmir.6371  PMID:27856407
  • Radin, J. M., Topol, E. J., Andersen, K. G., Steinhubl, S. R. A laboratory in your pocket Lancet  2016 388:1875-1875  PMID:27751390
  • Torkamani, A., Muse, E. D., Spencer, E. G., Rueda, M., Wagner, G. N., Lucas, J. R., Topol, E. J. Molecular autopsy for sudden unexpected death JAMA-Journal of the American Medical Association  2016 316:1492-1494  PMID:27727376
  • Dorsey, E. R., Topol, E. J. State of Telehealth REPLY New England Journal of Medicine  2016 375:1400-1400
  • Topol, E. The evangelist of individualized medicine Technology Review  2016 119:91-92
  • Topol, E. Digital medicine: empowering both patients and clinicians Lancet  2016 388:740-741  PMID:27560260
  • Steinhubl, S. R., Muse, E. D., Barrett, P. M., Topol, E. J. Off the cuff : rebooting blood pressure treatment Lancet  2016 388:749-749  PMID:27560266
  • Gollamudi, S. S., Topol, E. J., Wineinger, N. E. A framework for smartphone-enabled, patient-generated health data analysis PeerJ  2016 4  DOI:10.7717/peerj.2284  PMID:27547580  PMCID:PMC4975026
  • Topol, E. J. Money back guarantees for non-reproducible results? BMJ-British Medical Journal  2016 353  DOI:10.1136/bmj.i2770  PMID:27221803
  • Erikson, G. A., Bodian, D. L., Rueda, M., Molparia, B., Scott, E. R., Scott-Van Zeeland, A. A., Topol, S. E., Wineinger, N. E., Niederhuber, J. E., Topol, E. J., Torkamani, A. Whole-genome sequencing of a healthy aging cohort Cell  2016 165:1002-1011  DOI:10.1016/j.cell.2016.03.022  PMID:27114037  PMCID:PMC4860090
  • Steinhubl, S. R., Mehta, R. R., Ebner, G. S., Ballesteros, M. M., Waalen, J., Steinberg, G., Van Crocker Jr., P., Felicione, E., Carter, C. T., Edmonds, S., Honcz, J. P., Miralles, G. D., et al. Rationale and design of a home-based trial using wearable sensors to detect asymptomatic atrial fibrillation in a targeted population: The mHealth Screening To Prevent Strokes (mSToPS) trial American Heart Journal  2016 175:77-85  DOI:10.1016/j.ahj.2016.02.011  PMID:27179726
  • Barrett, P. M., Topol, E. J. Smartphone Medicine It Professional  2016 18:52-54
  • Barrett, P. M., Topol, E. J. To truly look inside Lancet  2016 387:1268-1269  PMID:27035018
  • Bloss, C. S., Wineinger, N. E., Peters, M., Boeldt, D. L., Ariniello, L., Kim, J. Y., Sheard, J., Komatireddy, R., Barrett, P., Topol, E. J. A prospective randomized trial examining health care utilization in individuals using multiple smartphone-enabled biosensors PeerJ  2016 4  DOI:10.7717/peerj.1554  PMID:26788432  PMCID:PMC4715435
  • Dorsey, E. R., Topol, E. J. State of telehealth New England Journal of Medicine  2016 375:154-161  DOI:10.1056/NEJMra1601705  PMID:27410924
  • Wilbanks, J. T., Topol, E. J. Stop the privatization of health data Nature  2016 535:345-348  PMID:27443724
  • Filkins, B. L., Kim, J. Y., Roberts, B., Armstrong, W., Miller, M. A., Hultner, M. L., Castillo, A. P., Ducom, J. C., Topol, E. J., Steinhubl, S. R. Privacy and security in the era of digital health: what should translational researchers know and do about it? American Journal of Translational Research  2016 8:1560-1580  PMID:27186282  PMCID:PMC4859641
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  • Schulman, S. P., GoldschmidtClermont, P. J., Topol, E. J., Califf, R. M., Navetta, F. I., Willerson, J. T., Chandra, N. C., Guerci, A. D., Ferguson, J. J., Harrington, R. A., Lincoff, A. M., Yakubov, S. J., et al. Effects of integrelin, a platelet glycoprotein iib/iiia receptor antagonist, in unstable angina - a randomized multicenter trial Circulation  1996 94:2083-2089  PMID:8901655
  • Obrien, J. E., Peterson, E. D., Keeler, G. P., Berdan, L. G., Ohman, E. M., Faxon, D. P., Jacobs, A. K., Topol, E. J., Califf, R. M. Relation between estrogen replacement therapy and restenosis after percutaneous coronary interventions Journal of the American College of Cardiology  1996 28:1111-1118  DOI:10.1016/s0735-1097(96)00306-3  PMID:8890803
  • Ohman, E. M., Armstrong, P. W., Christenson, R. H., Granger, C. B., Katus, H. A., Hamm, C. W., Ohanesian, M. A., Wagner, G. S., Kleiman, N. S., Harrell, F. E., Califf, R. M., Topol, E. J. Cardiac troponin t levels for risk stratification in acute myocardial ischemia New England Journal of Medicine  1996 335:1333-1341  DOI:10.1056/nejm199610313351801  PMID:8857016
  • Pilote, L., Miller, D. P., Califf, R. M., Rao, J. S., Weaver, W. D., Topol, E. J. Determinants of the use of coronary angiography and revascularization after thrombolysis for acute myocardial infarction New England Journal of Medicine  1996 335:1198-1205  DOI:10.1056/nejm199610173351606  PMID:8815943
  • White, H. D., Barbash, G. I., Califf, R. M., Simes, R. J., Granger, C. B., Weaver, W. D., Kleiman, N. S., Aylward, P. E., Gore, J. M., Vahanian, A., Lee, K. L., Ross, A. M., et al. Age and outcome with contemporary thrombolytic therapy - results from the gusto-i trial Circulation  1996 94:1826-1833  PMID:8873656
  • Horrigan, M. C. G., MacIsaac, A. I., Nicolini, F. A., Vince, D. G., Lee, P., Ellis, S. G., Topol, E. J. Reduction in myocardial infarct size by basic fibroblast growth factor after temporary coronary occlusion in a canine model Circulation  1996 94:1927-1933  PMID:8873670
  • Lefkovits, J., Blankenship, J. C., Anderson, K. M., Stoner, G. L., Talley, J. D., Worley, S. J., Weisman, H. F., Califf, R. M., Topol, E. J. Increased risk of non-q wave myocardial infarction after directional atherectomy is platelet dependent: Evidence from the epic trial Journal of the American College of Cardiology  1996 28:849-855  DOI:10.1016/s0735-1097(96)00239-2  PMID:8837559
  • vanderGiessen, W. J., Lincoff, A. M., Schwartz, R. S., vanBeusekom, H. M. M., Serruys, P. W., Holmes, D. R., Ellis, S. G., Topol, E. J. Marked inflammatory sequelae to implantation of biodegradable and nonbiodegradable polymers in porcine coronary arteries Circulation  1996 94:1690-1697  PMID:8840862
  • Abdelmeguid, A. E., Topol, E. J., Whitlow, P. L., Sapp, S. K., Ellis, S. G. Significance of mild transient release of creatine kinase-mb fraction after percutaneous coronary interventions Circulation  1996 94:1528-1536  PMID:8840840
  • Mak, K. H., Eisenberg, M. J., Plante, S., Strauss, B. H., Arheart, K. L., Topol, E. J. Absence of increased in-hospital complications with reused balloon catheters American Journal of Cardiology  1996 78:717-719  DOI:10.1016/s0002-9149(96)00443-2  PMID:8831419
  • Guzman, L. A., Labhasetwar, V., Song, C. X., Jang, Y. S., Lincoff, A. M., Levy, R., Topol, E. J. Local intraluminal infusion of biodegradable polymeric nanoparticles - a novel approach for prolonged drug delivery after balloon angioplasty Circulation  1996 94:1441-1448  PMID:8823004
  • Califf, R. M., White, H. D., VandeWerf, E. V., Sadowski, Z., Armstrong, P. W., Vahanian, A., Simoons, M. L., Simes, R. J., Lee, K. L., Topol, E. J. One-year results from the global utilization of streptokinase and tpa for occluded coronary arteries (gusto-i) trial Circulation  1996 94:1233-1238  PMID:8822974
  • Topol, E. J., Califf, R., Granger, C., VandeWerf, F., Aylward, P., Simes, J., Col, J., Armstrong, P., Vahanian, A., Neuhaus, K., Rutsch, W., Ardissino, D., et al. A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes New England Journal of Medicine  1996 335:775-782  DOI:10.1056/NEJM199609123351103  PMID:8778585
  • Pepine, C. J., Holmes, D. R., Block, P. C., Brinker, J. A., Mark, D. B., Mullins, C. E., Nissen, S. E., Topol, E. J., Williams, D. O., Goldberg, S., Hirshfeld, J. W., Serruys, P. W. Coronary artery stents Journal of the American College of Cardiology  1996 28:782-794  PMID:8772772
  • Topol, E. J. Early myocardial reperfusion: An assessment of current strategies in acute myocardial infarction European Heart Journal  1996 17:42-48  PMID:11824003
  • Holmes, D. R., Garratt, K. N., Isner, J. M., Kearney, M., Berdan, L. G., Schwartz, R. S., Califf, R. M., Topol, E. J. Effect of subintimal resection on initial outcome and restenosis for native coronary lesions and saphenous vein graft disease treated by directional coronary atherectomy - a report from the caveat i and ii investigators Journal of the American College of Cardiology  1996 28:645-651  DOI:10.1016/0735-1097(96)00185-4  PMID:8772751
  • Mark, D. B., Talley, J. D., Topol, E. J., Bowman, L., Lam, L. C., Anderson, K. M., Jollis, J. G., Cleman, M. W., Lee, K. L., Aversano, T., Untereker, W. J., DavidsonRay, L., et al. Economic assessment of platelet glycoprotein iib/iiia inhibition for prevention of ischemic complications of high-risk coronary angioplasty Circulation  1996 94:629-635  PMID:8772681
  • Peterson, E. D., Hathaway, W. R., Zabel, K. M., Pieper, K. S., Granger, C. B., Wagner, G. S., Topol, E. J., Bates, E. R., Simoons, M. L., Califf, R. M. Prognostic significance of precordial st segment depression during inferior myocardial infarction in the thrombolytic era: Results in 16,521 patients Journal of the American College of Cardiology  1996 28:305-312  DOI:10.1016/0735-1097(96)00133-7  PMID:8800102
  • Eisenberg, M. J., Topol, E. J. Prehospital administration of aspirin in patients with unstable angina and acute myocardial infarction Archives of Internal Medicine  1996 156:1506-1510  DOI:10.1001/archinte.156.14.1506  PMID:8687258
  • Challapalli, R., Lefkovits, J., Topol, E. J. Clinical trials of recombinant hirudin in acute coronary syndromes Coronary Artery Disease  1996 7:429-437  DOI:10.1097/00019501-199606000-00005  PMID:8889358
  • Abdelmeguid, A. E., Ellis, S. G., Sapp, S. K., Whitlow, P. L., Topol, E. J. Defining the appropriate threshold of creatine kinase elevation after percutaneous coronary interventions American Heart Journal  1996 131:1097-1105  DOI:10.1016/s0002-8703(96)90083-6  PMID:8644587
  • Newby, L. K., Rutsch, W. R., Califf, R. M., Simoons, M. L., Aylward, P. E., Armstrong, P. W., Woodlief, L. H., Lee, K. L., Topol, E. J., VandeWerf, F. Time from symptom onset to treatment and outcomes after thrombolytic therapy Journal of the American College of Cardiology  1996 27:1646-1655  PMID:8636549
  • Lefkovits, J., Ivanhoe, R. J., Califf, R. M., Bergelson, B. A., Anderson, K. M., Stoner, G. L., Weisman, H. F., Topol, E. J. Effects of platelet glycoprotein iib/iiia receptor blockade by a chimeric monoclonal antibody (abciximab) on acute and six-month outcomes after percutaneous transluminal coronary angioplasty for acute myocardial infarction American Journal of Cardiology  1996 77:1045-1051  DOI:10.1016/s0002-9149(96)00128-2  PMID:8644655
  • Almony, G. T., Lefkovits, J., Topol, E. J. Antiplatelet and anticoagulant use after myocardial infarction Clinical Cardiology  1996 19:357-365  PMID:8723593
  • Langer, A., Goodman, S. G., Topol, E. J., Charlesworth, A., Skene, A. M., Wilcox, R. G., Armstrong, P. W. Late assessment of thrombolytic efficacy (late) study: Prognosis in patients with non-q wave myocardial infarction Journal of the American College of Cardiology  1996 27:1327-1332  DOI:10.1016/0735-1097(96)00012-5  PMID:8626939
  • GottsaunerWolf, M., Moliterno, D. J., Lincoff, A. M., Topol, E. J. Restenosis - an open file Clinical Cardiology  1996 19:347-356  PMID:8723592
  • Lefkovits, J., Topol, E. J. The clinical role of platelet glycoprotein IIb/IIIa receptor inhibitors in ischemic heart disease Cleveland Clinic Journal of Medicine  1996 63:181-189  PMID:8665658
  • Redlitz, A., Nicolini, F. A., Malycky, J. L., Topol, E. J., Plow, E. F. Inducible carboxypeptidase activity - a role in clot lysis in vivo Circulation  1996 93:1328-1330  PMID:8641019
  • Barsness, G. W., Ohman, E. M., Califf, R. M., Kereiakes, D. J., George, B. S., Topol, E. J. The thrombolysis and angioplasty in myocardial infarction (tami) trials: A decade of reperfusion strategies Journal of Interventional Cardiology  1996 9:89-115  DOI:10.1111/j.1540-8183.1996.tb00604.x
  • Weaver, W. D., White, H. D., Wilcox, R. G., Aylward, P. E., Morris, D., Guerci, A., Ohman, M., Barbash, G. I., Betriu, A., Sadowski, Z., Topol, E. J., Califf, R. M. Comparisons of characteristics and outcomes among women and men with acute myocardial infarction treated with thrombolytic therapy JAMA-Journal of the American Medical Association  1996 275:777-782  DOI:10.1001/jama.275.10.777  PMID:8598594
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  • Newby, L. K., Califf, R. M., Guerci, A., Weaver, W. D., Col, J., Horgan, J. H., Mark, D. B., Stebbins, A., VandeWerf, F., Gore, J. M., Topol, E. J. Early discharge in the thrombolytic era: An analysis of criteria for uncomplicated infarction from the global utilization of streptokinase and t-pa for occluded coronary arteries (gusto) trial Journal of the American College of Cardiology  1996 27:625-632  PMID:8606274
  • Ellis, S. G., Omoigui, N., Bittl, J. A., Lincoff, M., Wolfe, M. W., Howell, G., Topol, E. J. Analysis and comparison of operator-specific outcomes in interventional cardiology - from a multicenter database of 4860 quality-controlled procedures Circulation  1996 93:431-439  PMID:8565159
  • LeBreton, H., Topol, E., Plow, E. F. Evidence for a pivotal role of platelets in vascular reocclusion and restenosis Cardiovascular Research  1996 31:235-236  DOI:10.1016/0008-6363(96)00005-3  PMID:8730399
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  • Mak, K. H., Eisenberg, M. J., Eccleston, D. S., Brown, K. J., Ellis, S. G., Topol, E. J. Cost-efficacy modeling of catheter reuse for percutaneous transluminal coronary angioplasty Journal of the American College of Cardiology  1996 28:106-111  DOI:10.1016/0735-1097(96)00097-6  PMID:8752801
  • Sgarbossa, E. B., Pinski, S. L., Barbagelata, A., Underwood, D. A., Gates, K. B., Topol, E. J., Califf, R. M., Wagner, G. S. Electrocardiographic diagnosis of evolving acute myocardial infarction in the presence of left bundle-branch block New England Journal of Medicine  1996 334:481-487  DOI:10.1056/nejm199602223340801  PMID:8559200
  • Metz, B. K., Topol, E. J. Heparin as an adjuvant to thrombolytic therapy in acute myocardial infarction Biomedicine & Pharmacotherapy  1996 50:243-253  DOI:10.1016/0753-3322(96)84821-9  PMID:8952863
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  • Muller, D. W. M., Gordon, D., Topol, E. J., Levy, R. J., Golomb, G. Sustained-release local hirulog therapy decreases early thrombosis but not neointimal thickening after arterial stenting American Heart Journal  1996 131:211-218  DOI:10.1016/s0002-8703(96)90343-9  PMID:8579010
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  • Karnash, S. L., Granger, C. B., White, H. D., Woodlief, L. H., Topol, E. J., Califf, R. M. Treating menstruating women with thrombolytic therapy - insights from the global utilization of streptokinase and tissue-plasminogen activator for occluded coronary-arteries (gusto-i) trial Journal of the American College of Cardiology  1995 26:1651-1656  DOI:10.1016/0735-1097(95)00386-x  PMID:7594099
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  • Gore, J. M., Granger, C. B., Simoons, M. L., Sloan, M. A., Weaver, D., White, H. D., Barbash, G. I., Vandewerf, F., Aylward, P. E., Topol, E. J., Califf, R. M. Stroke after thrombolysis - mortality and functional outcomes in the gusto-i trial Circulation  1995 92:2811-2818  PMID:7586246
  • Califf, R. M., Lincoff, A. M., Tcheng, J. E., Topol, E. J. An overview of the results of the EPIC trial European Heart Journal  1995 16:43-49  PMID:8869018
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  • Topol, E. J., Nissen, S. E. Our preoccupation with coronary luminology - the dissociation between clinical and angiographic findings in ischemic-heart-disease Circulation  1995 92:2333-2342  PMID:7554219
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  • Lefkovits, J., Holmes, D. R., Califf, R. M., Safian, R. D., Pieper, K., Keeler, G., Topol, E. J. Predictors and sequelae of distal embolization during saphenous-vein graft intervention from the caveat-ii trial Circulation  1995 92:734-740  PMID:7641351
  • Silver, M. J., Sutton, J. M., Hook, S., Lee, P., Malycky, J. L., Phillips, M. L., Ellis, S. G., Topol, E. J., Nicolini, F. A. Adjunctive selectin blockade successfully reduces infarct size beyond thrombolysis in the electrolytic canine coronary-artery model Circulation  1995 92:492-499  PMID:7543381
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  • Boehrer, J. D., Ellis, S. G., Pieper, K., Holmes, D. R., Keeler, G. P., Debowey, D., Chapekis, A. T., Leya, F., Mooney, M. R., Gottlieb, R. S., Serruys, P. W., Califf, R. M., et al. Directional atherectomy versus balloon angioplasty for coronary ostial and nonostial left anterior descending coronary-artery lesions - results from a randomized multicenter trial Journal of the American College of Cardiology  1995 25:1380-1386  DOI:10.1016/0735-1097(95)00008-r  PMID:7722137
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  • Pichard, A., Ivanhoe, R., Satler, L., Masden, R., Chapekis, A., Lee, K. L., Reen, B., Levine, G., Abbottsmith, C., Gottlieb, R. S., Stillabower, M., Chambers, J., et al. A multicenter, randomized trial of coronary angioplasty versus directional atherectomy for patients with saphenous vein bypass graft lesions Circulation  1995 91:1966-1974  PMID:7895354
  • Becker, R. C., Charlesworth, A., Wilcox, R. G., Hampton, J., Skene, A., Gore, J. M., Topol, E. J. Cardiac rupture associated with thrombolytic therapy - impact of time to treatment in the late assessment of thrombolytic efficacy (late) study Journal of the American College of Cardiology  1995 25:1063-1068  DOI:10.1016/0735-1097(94)00524-t  PMID:7897117
  • Villa, A. E., Guzman, L. A., Poptic, E. J., Labhasetwar, V., Dsouza, S., Farrell, C. L., Plow, E. F., Levy, R. J., Dicorleto, P. E., Topol, E. J. Effects of antisense c-myb oligonucleotides on vascular smooth-muscle cell-proliferation and response to vessel wall injury Circulation Research  1995 76:505-513  PMID:7895327
  • Simes, R. J., Topol, E. J., Holmes, D. R., White, H. D., Rutsch, W. R., Vahanian, A., Simoons, M. L., Morris, D., Betriu, A., Califf, R. M., Ross, A. M. Link between the angiographic substudy and mortality outcomes in a large randomized trial of myocardial reperfusion - importance of early and complete infarct artery reperfusion Circulation  1995 91:1923-1928  PMID:7895348
  • Ellis, S. G., Cowley, M. J., Whitlow, P. L., Vandormael, M., Lincoff, A. M., Disciascio, G., Dean, L. S., Topol, E. J. Prospective case-control comparison of percutaneous transluminal coronary revascularization in patients with multivessel disease treated in 1986-1987 versus 1991 - improved in-hospital and 12-month results Journal of the American College of Cardiology  1995 25:1137-1142  DOI:10.1016/0735-1097(94)00541-w  PMID:7897127
  • Williams, D. O., Baim, D. S., Bates, E., Bonan, R., Bost, J. E., Cowley, M., Faxon, D. P., Feit, F., Jones, R., Kellett, M. A., Kelsey, S. F., Sopko, G., et al. Coronary anatomic and procedural characteristics of patients randomized to coronary angioplasty in the bypass angioplasty revascularization investigation (bari) American Journal of Cardiology  1995 75:C27-C33  DOI:10.1016/s0002-9149(99)80392-0
  • Moliterno, D. J., Califf, R. M., Aguirre, F. V., Anderson, K., Sigmon, K. N., Weisman, H. F., Topol, E. J. Effect of platelet glycoprotein iib/iiia integrin blockade on activated clotting time during percutaneous transluminal coronary angioplasty or directional atherectomy (the epic trial) American Journal of Cardiology  1995 75:559-562  DOI:10.1016/s0002-9149(99)80616-x  PMID:7887377
  • Lee, K. L., Woodlief, L. H., Topol, E. J., Weaver, W. D., Betriu, A., Col, J., Simoons, M., Aylward, P., Vandewerf, F., Califf, R. M. Predictors of 30-day mortality in the era of reperfusion for acute myocardial-infarction - results from an international trial of 41 021 patients Circulation  1995 91:1659-1668  PMID:7882472
  • Moliterno, D. J., Elliott, J. M., Topol, E. J. Randomized trials of myocardial revascularization Current Problems in Cardiology  1995 20:128-190  DOI:10.1016/s0146-2806(06)80025-3
  • Topol, E. J. Novel antithrombotic approaches to coronary-artery disease American Journal of Cardiology  1995 75:B27-B33  DOI:10.1016/0002-9149(95)80007-f
  • Grines, C. L., Topol, E. J., Oneill, W. W., George, B. S., Kereiakes, D., Phillips, H. R., Leimberger, J. D., Woodlief, L. H., Califf, R. M. Effect of cigarette-smoking on outcome after thrombolytic therapy for myocardial-infarction Circulation  1995 91:298-303  PMID:7805231
  • Gersh, B. J., Topol, E. J. Angioplasty or thrombolysis in acute myocardial-infarction - dilate or dissolve Cleveland Clinic Journal of Medicine  1995 62:15-19  PMID:7859398
  • Mark, D. B., Hlatky, M. A., Califf, R. M., Naylor, C. D., Lee, K. L., Armstrong, P. W., Barbash, G., White, H., Simoons, M. L., Nelson, C. L., Clappchanning, N., Knight, J. D., et al. Cost-effectiveness of thrombolytic therapy with tissue-plasminogen activator as compared with streptokinase for acute myocardial-infarction New England Journal of Medicine  1995 332:1418-1424  DOI:10.1056/nejm199505253322106  PMID:7723799
  • Jang, Y. S., Lincoff, A. M., Plow, E. F., Topol, E. J. Cell-adhesion molecules in coronary-artery disease Journal of the American College of Cardiology  1994 24:1591-1601  PMID:7963103
  • Boehrer, J. D., Kereiakes, D. J., Navetta, F. I., Califf, R. M., Topol, E. J. Effects of profound platelet inhibition with c7e3 before coronary angioplasty on complications of coronary-bypass survey American Journal of Cardiology  1994 74:1166-1170  DOI:10.1016/0002-9149(94)90474-x  PMID:7977081
  • Kleiman, N. S., White, H. D., Ohman, E. M., Ross, A. M., Woodlief, L. H., Califf, R. M., Holmes, D. R., Bates, E., Pfisterer, M., Vahanian, A., Topol, E. J. Mortality within 24 hours of thrombolysis for myocardial-infarction - the importance of early reperfusion Circulation  1994 90:2658-2665  PMID:7994805
  • Reiner, J. S., Lundergan, C. F., Vandenbrand, M., Boland, J., Thompson, M. A., Machecourt, J., Py, A., Pilcher, G. S., Fink, C. A., Burton, J. R., Simoons, M. L., Califf, R. M., et al. Early angiography cannot predict postthrombolytic coronary reocclusion - observations from the gusto angiographic study Journal of the American College of Cardiology  1994 24:1439-1444  PMID:7930273
  • Maclsaac, A. I., Ellis, S. G., Muller, D. W., Topol, E. J., Whitlow, P. L. Comparison of 3 coronary stents - clinical and angiographic outcome after elective placement in 134 consecutive patients Catheterization and Cardiovascular Diagnosis  1994 33:199-204  DOI:10.1002/ccd.1810330302  PMID:7874711
  • Savage, M. P., Fischman, D. L., Schatz, R. A., Teirstein, P. S., Leon, M. B., Baim, D., Ellis, S. G., Topol, E. J., Hirshfeld, J. W., Cleman, M. W., Buchbinder, M., Bailey, S., et al. Long-term angiographic and clinical outcome after implantation of a balloon-expandable stent in the native coronary circulation Journal of the American College of Cardiology  1994 24:1207-1212  PMID:7930240
  • Ellis, S. G., Dasilva, E. R., Heyndrickx, G., Talley, J. D., Cernigliaro, C., Steg, G., Spaulding, C., Nobuyoshi, M., Erbel, R., Vassanelli, C., Topol, E. J. Randomized comparison of rescue angioplasty with conservative management of patients with early failure of thrombolysis for acute anterior myocardial-infarction Circulation  1994 90:2280-2284  PMID:7955184
  • Mark, D. B., Naylor, C. D., Hlatky, M. A., Califf, R. M., Topol, E. J., Granger, C. B., Knight, J. D., Nelson, C. L., Lee, K. L., Clappchanning, N. E., Sutherland, W., Pilote, L., et al. Use of medical resources and quality-of-life after acute myocardial-infarction in canada and the united-states New England Journal of Medicine  1994 331:1130-1135  DOI:10.1056/nejm199410273311706  PMID:7935638
  • Lincoff, A. M., Topol, E. J., Ellis, S. G. Local-drug delivery for the prevention of restenosis - fact, fancy, and future Circulation  1994 90:2070-2084  PMID:7923695
  • Tcheng, J. E., Ellis, S. G., George, B. S., Kereiakes, D. J., Kleiman, N. S., Talley, J. D., Wang, A. L., Weisman, H. F., Califf, R. M., Topol, E. J. Pharmacodynamics of chimeric glycoprotein iib/iiia integrin antiplatelet antibody fab 7e3 in high-risk coronary angioplasty Circulation  1994 90:1757-1764  PMID:7923659
  • Topol, E., Califf, R., Vandewerf, F., Ardissino, D., Armstrong, P., Aylward, P., Barbash, G., Bates, E., Beatt, K., Betriu, A., Chesebro, J., Col, J., et al. Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes Circulation  1994 90:1631-1637  PMID:7923645
  • Nissen, S. E., Pepine, C. J., Bashore, T. M., Block, P. C., Bonchek, L. I., Brinker, J. A., Carabello, B., Douglas, J. S., Elion, J. L., Hirshfeld, J. W., Holmes, D. R., Johnson, W. L., et al. Cardiac angiography without cine film - erecting a tower-of-babel in the cardiac-catheterization laboratory Journal of the American College of Cardiology  1994 24:834-837  PMID:8077561
  • Lefkovits, J., Topol, E. J. Direct thrombin inhibitors in cardiovascular medicine Circulation  1994 90:1522-1536  PMID:8087958
  • Steinberg, J. S., Hochman, J. S., Morgan, C. D., Dorian, P., Naylor, C. D., Theroux, P., Topol, E. J., Armstrong, P. W. Effects of thrombolytic therapy administered 6 to 24 hours after myocardial-infarction on the signal-averaged ecg - results of a multicenter randomized trial Circulation  1994 90:746-752  PMID:8044943
  • Faxon, D. P., Spiro, T. E., Minor, S., Cote, G., Douglas, J., Gottlieb, R., Califf, R., Dorosti, K., Topol, E., Gordon, J. B., Ohmen, M., Raizner, A., et al. Low-molecular-weight heparin in prevention of restenosis after angioplasty - results of enoxaparin restenosis (era) trial Circulation  1994 90:908-914  PMID:8044962
  • Holmes, D. R., Topol, E. J., Adelman, A. G., Cohen, E. A., Califf, R. M. Randomized trials of directional coronary atherectomy - implications for clinical-practice and future investigation Journal of the American College of Cardiology  1994 24:431-439  PMID:8034880
  • Braunwald, E., Jones, R. H., Mark, D. B., Brown, J., Brown, L., Cheitlin, M. D., Concannon, C. A., Cowan, M., Edwards, C., Fuster, V., Goldman, L., Green, L. A., et al. Diagnosing and managing unstable angina Circulation  1994 90:613-622  PMID:8026048
  • Wall, T. C., Califf, R. M., Blankenship, J., Talley, J. D., Tannenbaum, M., Schwaiger, M., Gacioch, G., Cohen, M. D., Sanz, M., Leimberger, J. D., Topol, E. J. Intravenous fluosol in the treatment of acute myocardial-infarction - results of the thrombolysis and angioplasty in myocardial-infarction-9 trial Circulation  1994 90:114-120  PMID:8025985
  • Brown, D. L., Macisaac, A. I., Topol, E. J. Pulmonary hemorrhage after intracoronary stent placement Journal of the American College of Cardiology  1994 24:91-94  PMID:8006287
  • Ellis, S. G., Lincoff, A. M., George, B. S., Kereiakes, D. J., Ohman, E. M., Krucoff, M. W., Califf, R. M., Topol, E. J. Randomized evaluation of coronary angioplasty for early timi-2 flow after thrombolytic therapy for the treatment of acute myocardial-infarction - a new look at an old study Coronary Artery Disease  1994 5:611-615  DOI:10.1097/00019501-199407000-00009  PMID:7952423
  • Defranco, A. C., Topol, E. J. Invasive strategies for acute myocardial-infarction in the elderly Cardiology in the Elderly  1994 2:274-289
  • Lee, K. L., Califf, R. M., Simes, J., Vandewerf, F., Topol, E. J. Holding gusto up to the light Annals of Internal Medicine  1994 120:876-881  PMID:8154647
  • Paranandi, S. N., Topol, E. J. Contemporary clinical-trials of restenosis Journal of Invasive Cardiology  1994 6:109-124  PMID:10147167
  • Flaherty, J. T., Pitt, B., Gruber, J. W., Heuser, R. R., Rothbaum, D. A., Burwell, L. R., George, B. S., Kereiakes, D. J., Deitchman, D., Gustafson, N., Brinker, J. A., Becker, L. C., et al. Recombinant human superoxide-dismutase (h-sod) fails to improve recovery of ventricular-function in patients undergoing coronary angioplasty far acute myocardial-infarction Circulation  1994 89:1982-1991  PMID:8181121
  • Topol, E. J., Califf, R. M., Weisman, H. F., Ellis, S. G., Tcheng, J. E., Worley, S., Ivanhoe, R., George, B. S., Fintel, D., Weston, M., Sigmon, K., Anderson, K. M., et al. Randomized trial of coronary intervention with antibody against platelet iib/iiia integrin for reduction of clinical restenosis - results at 6 months Lancet  1994 343:881-886  DOI:10.1016/s0140-6736(94)90007-8  PMID:7908357
  • Califf, R. M., Shadoff, N., Valett, N., Bates, E., Galeana, A., Knopf, W., Shaftel, J., Bender, M. J., Aversano, T., Raqueno, J., Gurbel, P., Cowfer, J., et al. Use of a monoclonal-antibody directed against the platelet glycoprotein iib/iiia receptor in high-risk coronary angioplasty New England Journal of Medicine  1994 330:956-961  PMID:8121459
  • Nicolini, F. A., Lee, P., Rios, G., Kottkemarchant, K., Topol, E. J. Combination of platelet fibrinogen receptor antagonist and direct thrombin inhibitor at low-doses markedly improves thrombolysis Circulation  1994 89:1802-1809  PMID:8149546
  • Lefkovits, J., Topol, E. J. Future-directions in thrombolysis for myocardial-infarction - what are the unanswered questions Coronary Artery Disease  1994 5:306-316  DOI:10.1097/00019501-199404000-00006  PMID:8044342
  • Topol, E. J., Fuster, V., Harrington, R. A., Califf, R. M., Kleiman, N. S., Kereiakes, D. J., Cohen, M., Chapekis, A., Gold, H. K., Tannenbaum, M. A., Rao, A. K., Debowey, D., et al. Recombinant hirudin for unstable angina-pectoris - a multicenter, randomized angiographic trial Circulation  1994 89:1557-1566  PMID:8149521
  • Sgarbossa, E. B., Topol, E. J. Semantic ambiguity, the non-nosology and myocardial-infarction Journal of Clinical Epidemiology  1994 47:441-446  DOI:10.1016/0895-4356(94)90165-1  PMID:7730869
  • Harrington, R. A., Sane, D. C., Califf, R. M., Sigmon, K. N., Abbottsmith, C. W., Candela, R. J., Lee, K. L., Topol, E. J. Clinical importance of thrombocytopenia occurring in the hospital phase after administration of thrombolytic therapy for acute myocardial-infarction Journal of the American College of Cardiology  1994 23:891-898  PMID:8106694
  • Rosenschein, U., Ellis, S. G., Haudenschild, C. C., Yakubov, S. J., Muller, D. W. M., Dick, R. J., Topol, E. J. Comparison of histopathologic coronary lesions obtained from directional atherectomy in stable angina versus acute coronary syndromes American Journal of Cardiology  1994 73:508-510  DOI:10.1016/0002-9149(94)90683-1  PMID:8141093
  • Holmes, D. R., Topol, E. J. Dilate or debulk Cleveland Clinic Journal of Medicine  1994 61:124-126  PMID:8194176
  • Villa, A. E., Guzman, L. A., Chen, W. L., Golomb, G., Levy, R. J., Topol, E. J. Local-delivery of dexamethasone for prevention of neointimal proliferation in a rat model of balloon angioplasty Journal of Clinical Investigation  1994 93:1243-1249  DOI:10.1172/jci117078  PMID:8132764
  • Sutton, J. M., Ellis, S. G., Roubin, G. S., Pinkerton, C. A., King, S. B., Raizner, A. E., Holmes, D. R., Kereiakes, D. J., Topol, E. J. Major clinical events after coronary stenting - the multicenter registry of acute and elective gianturco-roubin stent placement Circulation  1994 89:1126-1137  PMID:8124799
  • Hicks, R. J., Melon, P., Kalff, V., Wolfe, E., Dick, R. J., Popma, J. J., Topol, E., Schwaiger, M. Metabolic imaging by positron emission tomography early after myocardial-infarction as a predictor of recovery of myocardial-function after reperfusion Journal of Nuclear Cardiology  1994 1:124-137  DOI:10.1007/bf02984084  PMID:9420679
  • Kawai, C., Simoons, M. L., Baigent, C., Lenert, L. A., Collins, R., Lopezsendon, J., Parish, S., Knatterud, G., Visani, L., Halls, H., Nicklas, J., Mead, G., et al. Indications for fibrinolytic therapy in suspected acute myocardial infarction - collaborative overview of early mortality and major morbidity results from all randomized trials of more than 1000 patients Lancet  1994 343:311-322  PMID:7905143
  • Vandewerf, F., Santopinto, J., Cordero, F. A., Fainstein, D., Corinaldesi, A., Zavatti, D., Luppi, O., Iparraguirre, H. P., Hirschson, A., Piombo, A., Lapuente, A., Kritzer, J., et al. Randomized trial of ridogrel, a combined thromboxane a(2) synthase inhibitor and thromboxane a(2)/prostaglandin endoperoxide receptor antagonist, versus aspirin as adjunct to thrombolysis in patients with acute myocardial-infarction - the ridogrel versus aspirin patency trial (rapt) Circulation  1994 89:588-595  PMID:8313547
  • Ellis, S. G., Popma, J. J., Buchbinder, M., Franco, I., Leon, M. B., Kent, K. M., Pichard, A. D., Satler, L. F., Topol, E. J., Whitlow, P. L. Relation of clinical presentation, stenosis morphology, and operator technique to the procedural results of rotational atherectomy and rotational atherectomy-facilitated angioplasty Circulation  1994 89:882-892  PMID:8313578
  • Topol, E. J., Califf, R. M. Scorecard cardiovascular medicine - its impact and future-directions Annals of Internal Medicine  1994 120:65-70  PMID:8250458
  • Topol, E. J. Validation of the early open infarct vessel hypothesis American Journal of Cardiology  1993 72:G40-G45  DOI:10.1016/0002-9149(93)90106-m
  • Lincoff, A. M., Califf, R. M., Ellis, S. G., Sigmon, K. N., Lee, K. L., Leimberger, J. D., Topol, E. J. Thrombolytic therapy for women with myocardial-infarction - is there a gender-gap Journal of the American College of Cardiology  1993 22:1780-1787  PMID:8245328
  • Ross, A. M., Simoons, M. L., Lundergan, C., Thompson, M., Reiner, J., Deychak, Y., Rohrbeck, S., Coyne, K., Walker, P., Cho, S., Greenhouse, S., Lee, K., et al. The effects of tissue-plasminogen activator, streptokinase, or both on coronary-artery patency, ventricular-function, and survival after acute myocardial-infarction New England Journal of Medicine  1993 329:1615-1622  PMID:8232430
  • Bernardi, M. M., Califf, R. M., Kleiman, N., Ellis, S. G., Topol, E. J. Lack of usefulness of prolonged bleeding times in predicting hemorrhagic events in patients receiving the 7e3 glycoprotein iib/iiia platelet antibody American Journal of Cardiology  1993 72:1121-1125  DOI:10.1016/0002-9149(93)90979-m  PMID:8237799
  • Brown, D. L., Topol, E. J. Stroke complicating percutaneous coronary revascularization American Journal of Cardiology  1993 72:1207-1209  DOI:10.1016/0002-9149(93)90998-r  PMID:8237818
  • Ohman, E. M., Topol, E. J., Califf, R. M., Bates, E. R., Ellis, S. G., Kereiakes, D. J., George, B. S., Samaha, J. K., Kline, E., Sigmon, K. N., Stack, R. S. An analysis of the cause of early mortality after administration of thrombolytic therapy Coronary Artery Disease  1993 4:957-964  DOI:10.1097/00019501-199311000-00002  PMID:8173712
  • Topol, E. J. Breaking the thrombolytic gridlock - insights from the gusto trial Cleveland Clinic Journal of Medicine  1993 60:445-447  PMID:8287504
  • Nath, F. C., Muller, D. W. M., Rosenschein, U., Ellis, S. G., Topol, E. J. Heparin monitoring during coronary intervention - activated clotting time versus activated partial thromboplastin time Canadian Journal of Cardiology  1993 9:797-801  PMID:8281479
  • Cowley, M. J., Vandermael, M., Topol, E. J., Whitlow, P. L., Dean, L. S., Bulle, T. M., Ellis, S. G. Is traditionally defined complete revascularization needed for patients with multivessel disease treated by elective coronary angioplasty Journal of the American College of Cardiology  1993 22:1289-1297  PMID:8227782
  • Baim, D. S., Hinohara, T., Holmes, D., Topol, E., Pinkerton, C., King, S. B., Whitlow, P., Kereiakes, D., Farley, B., Simpson, J. B. Results of directional coronary atherectomy during multicenter preapproval testing American Journal of Cardiology  1993 72:6E-11E  DOI:10.1016/0002-9149(93)91032-d  PMID:8213572
  • Ohman, E. M., Christenson, R. H., Califf, R. M., George, B. S., Samaha, J. K., Kereiakes, D. J., Worley, S. J., Wall, T. C., Berrios, E., Sigmon, K. N., Lee, K., Topol, E. J. Noninvasive detection of reperfusion after thrombolysis based on serum creatine-kinase mb changes and clinical-variables American Heart Journal  1993 126:819-826  DOI:10.1016/0002-8703(93)90694-5  PMID:8213437
  • Macisaac, A. I., Thomas, J. D., Topol, E. J. Toward the quiescent coronary plaque Journal of the American College of Cardiology  1993 22:1228-1241  PMID:8104965
  • Hampton, J., Wilcox, R., Armstrong, P., Aylward, P., Bett, N., Charbonnier, B., Gulba, D., Heikkila, J., Jensen, G., Lopezbescos, L., Moulopoulos, S., Seabragomes, R., et al. Late assessment of thrombolytic efficacy (late) study with alteplase 6-24 hours after onset of acute myocardial-infarction Lancet  1993 342:759-766  PMID:8103874
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  • Krucoff, M. W., Croll, M. A., Pope, J. E., Granger, C. B., Oconnor, C. M., Sigmon, K. N., Wagner, B. L., Ryan, J. A., Lee, K. L., Kereiakes, D. J., Samaha, J. K., Worley, S. J., et al. Continuous 12-lead st-segment recovery analysis in the tami 7 study - performance of a noninvasive method for real-time detection of failed myocardial reperfusion Circulation  1993 88:437-446  PMID:8339407
  • Topol, E. J., Leya, F., Pinkerton, C. A., Whitlow, P. L., Hofling, B., Simonton, C. A., Masden, R. R., Serruys, P. W., Leon, M. B., Williams, D. O., King, S. B., Mark, D. B., et al. A comparison of directional atherectomy with coronary angioplasty in patients with coronary-artery disease New England Journal of Medicine  1993 329:221-227  DOI:10.1056/nejm199307223290401  PMID:8316266
  • Topol, E. J., Plow, E. F. Clinical-trials of platelet receptor inhibitors Thrombosis and Haemostasis  1993 70:94-98  PMID:8236122
  • George, B. S., Voorhees, W. D., Roubin, G. S., Fearnot, N. E., Pinkerton, C. A., Raizner, A. E., King, S. B., Holmes, D. R., Topol, E. J., Kereiakes, D. J., Hartzler, G. O. Multicenter investigation of coronary stenting to treat acute or threatened closure after percutaneous transluminal coronary angioplasty - clinical and angiographic outcomes Journal of the American College of Cardiology  1993 22:135-143  PMID:8509533
  • Defeyter, Pimj, Vansuylen, R. J., Dejaegere, P. P. T., Topol, E. J., Serruys, P. W. Balloon angioplasty for the treatment of lesions in saphenous-vein bypass grafts Journal of the American College of Cardiology  1993 21:1539-1549  PMID:8496517
  • Casale, P. N., Whitlow, P. L., Franco, I., Grigera, F., Pashkow, F. J., Topol, E. J. Comparison of major complication rates with new atherectomy devices for percutaneous coronary intervention in women versus men American Journal of Cardiology  1993 71:1221-1223  DOI:10.1016/0002-9149(93)90650-2  PMID:8480650
  • Topol, E. J., Ellis, S. G., Cosgrove, D. M., Bates, E. R., Muller, D. W. M., Schork, N. J., Schork, M. A., Loop, F. D. Analysis of coronary angioplasty practice in the united-states with an insurance-claims data-base Circulation  1993 87:1489-1497  PMID:8141866
  • Lee, K. S., Topol, E. J., Stewart, W. J. Atypical presentation of papillary fibroelastoma mimicking multiple vegetations in suspected subacute bacterial-endocarditis American Heart Journal  1993 125:1443-1445  DOI:10.1016/0002-8703(93)91025-a  PMID:8480605
  • Harrison, J. K., Califf, R. M., Woodlief, L. H., Kereiakes, D., George, B. S., Stack, R. S., Ellis, S. G., Lee, K. L., Oneill, W., Topol, E. J. Systolic left-ventricular function after reperfusion therapy for acute myocardial-infarction - an analysis of determinants of improvement Circulation  1993 87:1531-1541  PMID:8491008
  • Topol, E. J., Bonan, R., Jewitt, D., Sigwart, U., Kakkar, V. V., Rothman, M., Debono, D., Ferguson, J., Willerson, J. T., Strony, J., Ganz, P., Cohen, M. D., et al. Use of a direct antithrombin, hirulog, in place of heparin during coronary angioplasty Circulation  1993 87:1622-1629  PMID:8491018
  • Chapman, G. D., Ohman, M., Topol, E. J., Candela, R. J., Kereiakes, D. J., Samaha, J., Berrios, E., Pieper, K. S., Young, S. Y., Califf, R. M. Minimizing the risk of inappropriately administering thrombolytic therapy (thrombolysis and angioplasty in myocardial-infarction tami study-group) American Journal of Cardiology  1993 71:783-787  DOI:10.1016/0002-9149(93)90824-v  PMID:8456754
  • Lincoff, A. M., Topol, E. J., Chapekis, A. T., George, B. S., Candela, R. J., Muller, D. W. M., Zimmerman, C. A., Ellis, S. G. Intracoronary stenting compared with conventional therapy for abrupt vessel closure complicating coronary angioplasty - a matched case-control study Journal of the American College of Cardiology  1993 21:866-875  PMID:8450155
  • Granger, C. B., Califf, R. M., Young, S., Candela, R., Samaha, J., Worley, S., Kereiakes, D. J., Topol, E. J. Outcome of patients with diabetes-mellitus and acute myocardial-infarction treated with thrombolytic agents Journal of the American College of Cardiology  1993 21:920-925  PMID:8450161
  • Sane, D. C., Califf, R. M., Sigmon, K. N., Topol, E. J., Stump, D. C. Effect of heparin administration on fibrinogenolysis during thrombolytic therapy with tissue plasminogen activator for acute myocardial infarction Fibrinolysis  1993 7:103-107  DOI:10.1016/0268-9499(93)90030-y
  • Wall, T. C., Califf, R. M., Ellis, S. G., Sigmon, K., Kereiakes, D., George, B. S., Samaha, J., Sane, D., Stump, D. C., Stack, R. S., Topol, E. J. Lack of impact of early catheterization and fibrin specificity on bleeding complications after thrombolytic therapy Journal of the American College of Cardiology  1993 21:597-603  PMID:8436740
  • Popma, J. J., Decesare, N. B., Pinkerton, C. A., Kereiakes, D. J., Whitlow, P., King, S. B., Topol, E. J., Holmes, D. R., Leon, M. B., Ellis, S. G. Quantitative-analysis of factors influencing late lumen loss and restenosis after directional coronary atherectomy American Journal of Cardiology  1993 71:552-557  DOI:10.1016/0002-9149(93)90510-j  PMID:8438740
  • Nath, F. C., Muller, D. W. M., Ellis, S. G., Rosenschein, U., Chapekis, A., Quain, L., Zimmerman, C., Topol, E. J. Thrombosis of a flexible coil coronary stent - frequency, predictors and clinical outcome Journal of the American College of Cardiology  1993 21:622-627  PMID:8436743
  • Kalff, V., Hicks, R. J., Hutchins, G., Topol, E., Schwaiger, M. Use of c-11 acetate and dynamic positron emission tomography to assess regional myocardial oxygen-consumption in patients with acute myocardial-infarction receiving thrombolysis or coronary angioplasty American Journal of Cardiology  1993 71:529-535  DOI:10.1016/0002-9149(93)90507-9  PMID:8438738
  • Ellis, S. G., Tcheng, J. E., Navetta, F. I., Muller, D. W. M., Weisman, H. F., Smith, C., Anderson, K. M., Califf, R. M., Topol, E. J. Safety and antiplatelet effect of murine monoclonal-antibody 7e3 fab directed against platelet glycoprotein-iib/iiia in patients undergoing elective coronary angioplasty Coronary Artery Disease  1993 4:167-175  DOI:10.1097/00019501-199302000-00007  PMID:8269208
  • Lincoff, A. M., Topol, E. J. Illusion of reperfusion. Does anyone achieve optimal reperfusion during acute myocardial infarction? Circulation  1993 87:1792-1805  PMID:8353902
  • Doorey, A. J., Michelson, E. L., Topol, E. J. Thrombolytic therapy of acute myocardial-infarction - keeping the unfulfilled promises JAMA-Journal of the American Medical Association  1992 268:3108-3114  DOI:10.1001/jama.268.21.3108  PMID:1433742
  • Sutton, J. M., Topol, E. J. Left ventricular function assessment and acute myocardial infarction Current Opinion in Cardiology  1992 7:1035-1045  DOI:10.1097/00001573-199212000-00016
  • Ellis, S. G., Savage, M., Fischman, D., Baim, D. S., Leon, M., Goldberg, S., Hirshfeld, J. W., Cleman, M. W., Teirstein, P. S., Walker, C., Bailey, S., Buchbinder, M., et al. Restenosis after placement of palmaz-schatz stents in native coronary-arteries - initial results of a multicenter experience Circulation  1992 86:1836-1844  PMID:1451256
  • Popma, J. J., Califf, R. M., Ellis, S. G., George, B. S., Kereiakes, D. J., Samaha, J. K., Worley, S. J., Anderson, J. L., Stump, D., Woodlief, L., Sigmon, K., Wall, T. C., et al. Mechanism of benefit of combination thrombolytic therapy for acute myocardial-infarction - a quantitative angiographic and hematologic study Journal of the American College of Cardiology  1992 20:1305-1312  PMID:1430679
  • Rosenschein, U., Yakubov, S. J., Guberinich, D., Bach, D. S., Sonda, P. L., Abrams, G. D., Topol, E. J. Shock-wave thrombus ablation, a new method for noninvasive mechanical thrombolysis American Journal of Cardiology  1992 70:1358-1361  DOI:10.1016/0002-9149(92)90775-t  PMID:1442591
  • Ellis, S. G., Mooney, M. R., George, B. S., Dasilva, E. E. R., Talley, J. D., Flanagan, W. H., Topol, E. J., Griffin, B., Samaha, J., Sawicki, E., Mooney, J., Chapekis, A. T., et al. Randomized trial of late elective angioplasty versus conservative management for patients with residual stenoses after thrombolytic treatment of myocardial-infarction Circulation  1992 86:1400-1406  PMID:1423952
  • Williamson, B. D., Muller, D. W. M., Topol, E. J. Should older patients with acute myocardial-infarction receive thrombolytic therapy Drugs & Aging  1992 2:461-468  PMID:1493350
  • Schwartz, R. S., Holmes, D. R., Topol, E. J. The restenosis paradigm revisited - an alternative proposal for cellular mechanisms Journal of the American College of Cardiology  1992 20:1284-1293  PMID:1401633
  • Rosenschein, U., Ellis, S. G., Yakubov, S. J., Haudenschild, C. C., Dick, R. J., Topol, E. J. Histopathologic correlates of coronary lesion angiographic morphology - lessons from a directional atherectomy experience Coronary Artery Disease  1992 3:953-961
  • Grambow, D. W., Topol, E. J. Effect of maximal medical therapy on refractoriness of unstable angina-pectoris American Journal of Cardiology  1992 70:577-581  DOI:10.1016/0002-9149(92)90194-4  PMID:1354937
  • Granger, C. B., Califf, R. M., Topol, E. J. Thrombolytic therapy for acute myocardial-infarction - a review Drugs  1992 44:293-325  DOI:10.2165/00003495-199244030-00002  PMID:1382931
  • Arnold, A. Z., Topol, E. J. Assessment of reperfusion after thrombolytic therapy for myocardial-infarction American Heart Journal  1992 124:441-447  DOI:10.1016/0002-8703(92)90611-x  PMID:1636587
  • Muller, D. W. M., Topol, E. J., Abrams, G. D., Gallagher, K. P., Ellis, S. G. Intramural methotrexate therapy for the prevention of neointimal thickening after balloon angioplasty Journal of the American College of Cardiology  1992 20:460-466  PMID:1386089
  • Topol, E. J., Califf, R. M., Vandormael, M., Grines, C. L., George, B. S., Sanz, M. L., Wall, T., Obrien, M., Schwaiger, M., Aguirre, F. V., Young, S., Popma, J. J., et al. A randomized trial of late reperfusion therapy for acute myocardial infarction Circulation  1992 85:2090-2099  PMID:1591828
  • Popma, J. J., Topol, E. J., Hinohara, T., Pinkerton, C. A., Baim, D. S., King, S. B., Holmes, D. R., Whitlow, P. L., Kereiakes, D. J., Hartzler, G. O., Kent, K. M., Ellis, S. G., et al. Abrupt vessel closure after directional coronary atherectomy Journal of the American College of Cardiology  1992 19:1372-1379  PMID:1593028
  • Topol, E. J., Armstrong, P., Vandewerf, F., Kleiman, N., Lee, K., Morris, D., Simoons, M., Barbash, G., White, H., Califf, R. M. Confronting the issues of patient safety and investigator conflict-of-interest in an international clinical-trial of myocardial reperfusion Journal of the American College of Cardiology  1992 19:1123-1128  PMID:1564212
  • Lincofe, A. M., Popma, J. J., Ellis, S. G., Hacker, J. A., Topol, E. J. Abrupt vessel closure complicating coronary angioplasty - clinical, angiographic and therapeutic profile Journal of the American College of Cardiology  1992 19:926-935  PMID:1552113
  • Wall, T. C., Califf, R. M., George, B. S., Ellis, S. G., Samaha, J. K., Kereiakes, D. J., Worley, S. J., Sigmon, K., Topol, E. J. Accelerated plasminogen-activator dose regimens for coronary thrombolysis Journal of the American College of Cardiology  1992 19:482-489  PMID:1537998
  • Gacioch, G. M., Ellis, S. G., Lee, L., Bates, E. R., Kirsh, M., Walton, J. A., Topol, E. J. Cardiogenic-shock complicating acute myocardial-infarction - the use of coronary angioplasty and the integration of the new support devices into patient-management Journal of the American College of Cardiology  1992 19:647-653  PMID:1538023
  • Decesare, N. B., Popma, J. J., Holmes, D. R., Dick, R. J., Whitlow, P. L., King, S. B., Pinkerton, C. A., Kereiakes, D. J., Topol, E. J., Haudenschild, C. C., Ellis, S. G. Clinical angiographic and histologic correlates of ectasia after directional coronary atherectomy American Journal of Cardiology  1992 69:314-319  DOI:10.1016/0002-9149(92)90226-o  PMID:1734641
  • Muller, D. W. M., Ellis, S. G., Topol, E. J. Experimental-models of coronary-artery restenosis Journal of the American College of Cardiology  1992 19:418-432  PMID:1732371
  • Muller, D. W. M., Topol, E. J. Thrombolytic therapy - adjuvant mechanical intervention for acute myocardial-infarction American Journal of Cardiology  1992 69:A60-A70  DOI:10.1016/0002-9149(92)91172-z
  • Muller, D. W. M., Shamir, K. J., Ellis, S. G., Topol, E. J. Peripheral vascular complications after conventional and complex percutaneous coronary interventional procedures American Journal of Cardiology  1992 69:63-68  DOI:10.1016/0002-9149(92)90677-q  PMID:1729869
  • Kirshenbaum, J. M., Bahr, R. D., Flaherty, J. T., Gurewich, V., Levine, H. J., Loscalzo, J., Schumacher, R. R., Topol, E. J., Wahr, D. W., Braunwald, E. Clot-selective coronary thrombolysis with low-dose synergistic combinations of single-chain urokinase-type plasminogen-activator and recombinant tissue-type plasminogen-activator American Journal of Cardiology  1991 68:1564-1569  DOI:10.1016/0002-9149(91)90310-h  PMID:1746455
  • Ellis, S. G., Myler, R. K., King, S. B., Douglas, J. S., Topol, E. J., Shaw, R. E., Stertzer, S. H., Roubin, G. S., Murphy, M. C. Causes and correlates of death after unsupported coronary angioplasty - implications for use of angioplasty and advanced support techniques in high-risk settings American Journal of Cardiology  1991 68:1447-1451  DOI:10.1016/0002-9149(91)90277-r  PMID:1746425
  • Muller, D. W. M., Topol, E. J., Ellis, S. G., Woodlief, L. H., Sigmon, K. N., Kereiakes, D. J., George, B. S., Worley, S. J., Samaha, J. K., Phillips, H., Califf, R. M. Determinants of the need for early acute intervention in patients treated conservatively after thrombolytic therapy for acute myocardial-infarction Journal of the American College of Cardiology  1991 18:1594-1601  PMID:1960302
  • Popma, J. J., Decesare, N. B., Ellis, S. G., Holmes, D. R., Pinkerton, C. A., Whitlow, P., King, S. B., Ghazzal, Z. M. B., Topol, E. J., Garratt, K. N., Kereiakes, D. J. Clinical, angiographic and procedural correlates of quantitative coronary dimensions after directional coronary atherectomy Journal of the American College of Cardiology  1991 18:1183-1189  PMID:1918694
  • Topol, E. J. Which thrombolytic agent should one choose Progress in Cardiovascular Diseases  1991 34:165-178  DOI:10.1016/0033-0620(91)90011-a  PMID:1947122
  • Tenaglia, A. N., Califf, R. M., Candela, R. J., Kereiakes, D. J., Berrios, E., Young, S. Y., Stack, R. S., Topol, E. J. Thrombolytic therapy in patients requiring cardiopulmonary-resuscitation American Journal of Cardiology  1991 68:1015-1019  DOI:10.1016/0002-9149(91)90488-7  PMID:1927913
  • Lee, P. N. V., Muller, D. W. M., Popma, J. J., Ellis, S. G., Topol, E. J. A comparison of clinical and quantitative angiographic outcomes of coronary stenting in elective and emergency settings: a single center experience Coronary Artery Disease  1991 2:945-951
  • Dellborg, M., Topol, E. J., Swedberg, K. Dynamic qrs complex and st segment vectorcardiographic monitoring can identify vessel patency in patients with acute myocardial-infarction treated with reperfusion therapy American Heart Journal  1991 122:943-948  DOI:10.1016/0002-8703(91)90455-q  PMID:1927880
  • Dick, R. J., Popma, J. J., Muller, D. W. M., Burek, K. A., Topol, E. J. In-hospital costs associated with new percutaneous coronary devices American Journal of Cardiology  1991 68:879-885  DOI:10.1016/0002-9149(91)90403-8  PMID:1927947
  • Bates, E. R., Topol, E. J. Limitations of thrombolytic therapy for acute myocardial-infarction complicated by congestive-heart-failure and cardiogenic-shock Journal of the American College of Cardiology  1991 18:1077-1084  PMID:1894853
  • Topol, E. J. Integration of anticoagulation, thrombolysis and coronary angioplasty for unstable angina-pectoris American Journal of Cardiology  1991 68:B136-B141  DOI:10.1016/0002-9149(91)90396-3
  • Muller, D. W. M., Topol, E. J. Implantable devices in the coronary-artery - from metal to genes Trends in Cardiovascular Medicine  1991 1:225-232  DOI:10.1016/1050-1738(91)90026-b  PMID:21239300
  • Morris, J. A., Muller, D. W. M., Topol, E. J. Combination thrombolytic therapy - a comparison of simultaneous and sequential regimens of tissue plasminogen-activator and urokinase American Heart Journal  1991 122:375-380  DOI:10.1016/0002-8703(91)90988-t  PMID:1907086
  • Kereiakes, D. J., Califf, R. M., George, B. S., Ellis, S., Samaha, J., Stack, R., Martin, L. H., Young, S., Topol, E. J. Coronary-bypass surgery improves global and regional left-ventricular function following thrombolytic therapy for acute myocardial-infarction American Heart Journal  1991 122:390-399  DOI:10.1016/0002-8703(91)90991-p  PMID:1907087
  • Ellis, S. G., Decesare, N. B., Pinkerton, C. A., Whitlow, P., King, S. B., Ghazzal, Z. M. B., Kereiakes, D. J., Popma, J. J., Menke, K. K., Topol, E. J., Holmes, D. R. Relation of stenosis morphology and clinical presentation to the procedural results of directional coronary atherectomy Circulation  1991 84:644-653  PMID:1860208
  • Popma, J. J., Topol, E. J. Adjuncts to thrombolysis for myocardial reperfusion Annals of Internal Medicine  1991 115:34-44  PMID:1675557
  • Ellis, S. G., Cowley, M. J., Disciascio, G., Deligonul, U., Topol, E. J., Bulle, T. M., Vandormael, M. G. Determinants of 2-year outcome after coronary angioplasty in patients with multivessel disease on the basis of comprehensive preprocedural evaluation - implications for patient selection Circulation  1991 83:1905-1914  PMID:2040043
  • Topol, E. J., Holmes, D. R., Rogers, W. J. Coronary angiography after thrombolytic therapy for acute myocardial-infarction Annals of Internal Medicine  1991 114:877-885  PMID:2014950
  • Schatz, R. A., Goldberg, S., Leon, M., Baim, D., Hirshfeld, J., Cleman, M., Ellis, S., Topol, E. Clinical-experience with the palmaz-schatz coronary stent Journal of the American College of Cardiology  1991 17:B155-B159
  • Muller, D. W. M., Ellis, S. G., Topol, E. J. Colchicine and antineoplastic therapy for the prevention of restenosis after percutaneous coronary interventions Journal of the American College of Cardiology  1991 17:B126-B131
  • Califf, R. M., Topol, E. J., Stack, R. S., Ellis, S. G., George, B. S., Kereiakes, D. J., Samaha, J. K., Worley, S. J., Anderson, J. L., Harrelson-Woodlief, S. L., Wall, T. C., Phillips, H. R., et al. Evaluation of combination thrombolytic therapy and timing of cardiac-catheterization in acute myocardial-infarction - results of thrombolysis and angioplasty in myocardial-infarction phase-5 randomized trial Circulation  1991 83:1543-1556  PMID:1902405
  • Ellis, S. G., Bates, E. R., Schaible, T., Weisman, H. F., Pitt, B., Topol, E. J. Prospects for the use of antagonists to the platelet glycoprotein-IIb glycoprotein-IIIa receptor to prevent postangioplasty restenosis and thrombosis Journal of the American College of Cardiology  1991 17:B89-B95
  • Dick, R. J. L., Haudenschild, C. C., Popma, J. J., Ellis, S. G., Muller, D. W., Topol, E. J. Directional atherectomy for total coronary occlusions Coronary Artery Disease  1991 2:189-199  DOI:10.1097/00019501-199104000-00010
  • Mark, D. B., Sigmon, K., Topol, E. J., Kereiakes, D. J., Pryor, D. B., Candela, R. J., Califf, R. M. Identification of acute myocardial-infarction patients suitable for early hospital discharge after aggressive interventional therapy - results from the thrombolysis and angioplasty in acute myocardial-infarction registry Circulation  1991 83:1186-1193  PMID:2013140
  • Muller, D. W. M., Topol, E. J., Ellis, S. G., Sigmon, K. N., Lee, K., Califf, R. M. Multivessel coronary-artery disease - a key predictor of short-term prognosis after reperfusion therapy for acute myocardial-infarction American Heart Journal  1991 121:1042-1049  DOI:10.1016/0002-8703(91)90661-z  PMID:1901190
  • Sutton, J. M., Topol, E. J. Significance of a negative exercise thallium test in the presence of a critical residual stenosis after thrombolysis for acute myocardial-infarction Circulation  1991 83:1278-1286  PMID:1901529
  • Topol, E. J., Agnelli, G. Strategies for administration of tissue plasminogen-activator Molecular Biology & Medicine  1991 8:219-234  PMID:1806764
  • Stewart, R. E., Kander, N., Juni, J. E., Ellis, S. G., Oneill, W. W., Schork, A., Topol, E. J., Schwaiger, M. Submaximal exercise tl-201 spect for assessment of interventional therapy in patients with acute myocardial-infarction American Heart Journal  1991 121:1033-1041  DOI:10.1016/0002-8703(91)90660-a  PMID:1901189
  • Sane, D. C., Stump, D. C., Topol, E. J., Sigmon, K. N., Kereiakes, D. J., George, B. S., Mantell, S. J., Macy, E., Collen, D., Califf, R. M. Correlation between base-line plasminogen-activator inhibitor levels and clinical outcome during therapy with tissue plasminogen-activator for acute myocardial-infarction Thrombosis and Haemostasis  1991 65:275-279  PMID:1904653
  • Lincoff, A. M., Popma, J. J., Ellis, S. G., Vogel, R. A., Topol, E. J. Percutaneous support devices for high-risk or complicated coronary angioplasty Journal of the American College of Cardiology  1991 17:770-780  PMID:1993799
  • Ohman, E. M., Califf, R. M., George, B. S., Quigley, P. J., Kereiakes, D. J., Harrelson-Woodlief, S. L., Candela, R. J., Flanagan, C., Stack, R. S., Topol, E. J. The use of intraaortic balloon pumping as an adjunct to reperfusion therapy in acute myocardial-infarction American Heart Journal  1991 121:895-901  DOI:10.1016/0002-8703(91)90205-v  PMID:1900381
  • Ellis, S. G., Debowey, D., Bates, E. R., Topol, E. J. Treatment of recurrent ischemia after thrombolysis and successful reperfusion for acute myocardial-infarction - effect on in-hospital mortality and left-ventricular function Journal of the American College of Cardiology  1991 17:752-757  PMID:1993797
  • Popma, J. J., Dick, R. J. L., Haudenschild, C. C., Topol, E. J., Ellis, S. G. Atherectomy of right coronary ostial stenoses - initial and long-term results, technical features and histologic-findings American Journal of Cardiology  1991 67:431-434  DOI:10.1016/0002-9149(91)90057-r  PMID:1994670
  • Nabel, E. G., Topol, E. J., Galeana, A., Ellis, S. G., Bates, E. R., Werns, S. W., Walton, J. A., Muller, D. W., Schwaiger, M., Pitt, B. A randomized placebo-controlled trial of combined early intravenous captopril and recombinant tissue-type plasminogen-activator therapy in acute myocardial-infarction Journal of the American College of Cardiology  1991 17:467-473  PMID:1825097
  • Clemmensen, P., Bates, E. R., Califf, R. M., Hlatky, M. A., Aronson, L., George, B. S., Lee, K. L., Kereiakes, D. J., Gacioch, G., Berrios, E., Topol, E. J. Complete atrioventricular-block complicating inferior wall acute myocardial-infarction treated with reperfusion therapy American Journal of Cardiology  1991 67:225-230  DOI:10.1016/0002-9149(91)90550-5  PMID:1899319
  • Kereiakes, D. J., Topol, E. J., George, B. S., Stack, R. S., Abbottsmith, C. W., Ellis, S., Candela, R. J., Harrelson, L., Martin, L. H., Califf, R. M. Myocardial-infarction with minimal coronary atherosclerosis in the era of thrombolytic reperfusion Journal of the American College of Cardiology  1991 17:304-312  PMID:1899433
  • Schatz, R. A., Baim, D. S., Leon, M., Ellis, S. G., Goldberg, S., Hirshfeld, J. W., Cleman, M. W., Cabin, H. S., Walker, C., Stagg, J., Buchbinder, M., Teirstein, P. S., et al. Clinical-experience with the palmaz-schatz coronary stent - initial results of a multicenter study Circulation  1991 83:148-161  PMID:1984878
  • Sane, D. C., Stump, D. C., Topol, E. J., Sigmon, K. N., Clair, W. K., Kereiakes, D. J., George, B. S., Stoddard, M. F., Bates, E. R., Stack, R. S., Califf, R. M. Racial-differences in responses to thrombolytic therapy with recombinant tissue-type plasminogen-activator - increased fibrin(ogen)olysis in blacks Circulation  1991 83:170-175  PMID:1898641
  • Muller, D. W. M., Topol, E. J. Selection of patients with acute myocardial-infarction for thrombolytic therapy Annals of Internal Medicine  1990 113:949-960  PMID:2240919
  • Wall, T. C., Califf, R. M., Harrelson-Woodlief, S. L. ,, Mark, D. B., Honan, M., Abbotsmith, C. W., Candela, R., Berrios, E., Phillips, H. R., Topol, E. J. Usefulness of a pericardial friction rub after thrombolytic therapy during acute myocardial-infarction in predicting amount of myocardial damage American Journal of Cardiology  1990 66:1418-1421  DOI:10.1016/0002-9149(90)90526-7  PMID:2123603
  • Bates, E. R., Clemmensen, P. M., Califf, R. M., Gorman, L. E., Aronson, L. G., George, B. S., Kereiakes, D. J., Topol, E. J. Precordial st segment depression predicts a worse prognosis in inferior infarction despite reperfusion therapy Journal of the American College of Cardiology  1990 16:1538-1544  PMID:2123903
  • Topol, E. J. Can thrombolysis be improved? Hospital Formulary  1990 25:19-22
  • Topol, E. J., Wilson, V. E. Pivotal role of early and sustained infarct vessel patency in patients with acute myocardial-infarction Heart & Lung  1990 19:583-595  PMID:2228647
  • Muller, D. W. M., Ellis, S. G., Debowey, D. L., Topol, E. J. Quantitative angiographic comparison of the immediate success of coronary angioplasty, coronary atherectomy and endoluminal stenting American Journal of Cardiology  1990 66:938-942  DOI:10.1016/0002-9149(90)90929-u  PMID:2220616
  • Ellis, S. G., Topol, E. J. Results of percutaneous transluminal coronary angioplasty of high-risk angulated stenoses American Journal of Cardiology  1990 66:932-937  DOI:10.1016/0002-9149(90)90928-t  PMID:2220615
  • Muller, D. W. M., Topol, E. J., George, B. S., Kereiakes, D. J., Aronson, L. G., Lee, K. L., Abbottsmith, C. W., Ellis, S. G., Califf, R. M. 2-year outcome after angiographically documented myocardial reperfusion for acute coronary-occlusion American Journal of Cardiology  1990 66:796-801  DOI:10.1016/0002-9149(90)90354-4  PMID:2220575
  • Ellis, S. G., Vandormael, M. G., Cowley, M. J., Disciascio, G., Deligonul, U., Topol, E. J., Bulle, T. M. Coronary morphological and clinical determinants of procedural outcome with angioplasty for multivessel coronary-disease - implications for patient selection Circulation  1990 82:1193-1202  PMID:2401060
  • Abbottsmith, C. W., Topol, E. J., George, B. S., Stack, R. S., Kereiakes, D. J., Candela, R. J., Anderson, L. C., Harrelson-Woodlief, S. L. ,, Califf, R. M. Fate of patients with acute myocardial-infarction with patency of the infarct-related vessel achieved with successful thrombolysis versus rescue angioplasty Journal of the American College of Cardiology  1990 16:770-778  PMID:1698843
  • Ohman, E. M., Califf, R. M., Topol, E. J., Candela, R., Abbottsmith, C., Ellis, S., Sigmon, K. N., Kereiakes, D., George, B., Stack, R. Consequences of reocclusion after successful reperfusion therapy in acute myocardial-infarction Circulation  1990 82:781-791  PMID:2394002
  • Oconnor, C. M., Califf, R. M., Massey, E. W., Mark, D. B., Kereiakes, D. J., Candela, R. J., Abbottsmith, C., George, B., Stack, R. S., Aronson, L., Mantell, S., Topol, E. J. Stroke and acute myocardial-infarction in the thrombolytic era - clinical correlates and long-term prognosis Journal of the American College of Cardiology  1990 16:533-540  PMID:2117618
  • Popma, J. J., Topol, E. J. Accelerated, combined, and adjunctive thrombolytic strategies for acute myocardial-infarction Current Opinion in Cardiology  1990 5:482-489  DOI:10.1097/00001573-199008000-00017
  • George, B. S., Candela, R. J., Topol, E. J., Stack, R. S., Kereiakes, D. J., Abbottsmith, C. W., Masek, R., Pickel, A., Dillon, J., Harrelson, L., Califf, R. M. Brachial approach to emergency cardiac-catheterization during thrombolytic therapy for acute myocardial-infarction Catheterization and Cardiovascular Diagnosis  1990 20:221-226  DOI:10.1002/ccd.1810200402  PMID:2119888
  • Williams, D. O., Topol, E. J., Califf, R. M., Roberts, R., Mancini, G. B. J., Joelson, J. M., Ellis, S. G., Kleiman, N. S. Intravenous recombinant tissue-type plasminogen-activator in patients with unstable angina-pectoris - results of a placebo-controlled, randomized trial Circulation  1990 82:376-383  PMID:2115407
  • Samson, M., Sutton, J. M., Topol, E. J., Serruys, P. W. Coronary angioplasty in myocardial-infarction - where are we Annales de Cardiologie et d'Angéiologie  1990 39:371-377  PMID:2205155
  • Topol, E. J. Coronary angioplasty in myocardial infarction Hospital Practice  1990 25:73-76, 79  PMID:2109756
  • Kavanaugh, K. M., Topol, E. J. Acute intervention during myocardial-infarction in patients with prior coronary-bypass surgery American Journal of Cardiology  1990 65:924-926  DOI:10.1016/0002-9149(90)91440-h  PMID:2321545
  • Califf, R. M., Topol, E. J., George, B. S., Kereiakes, D. J., Aronson, L. G., Lee, K. L., Martin, L., Candela, R., Abbottsmith, C., Oneill, W. W., Pryor, D. B., Stack, R. S. One-year outcome after therapy with tissue plasminogen-activator - report from the thrombolysis and angioplasty in myocardial-infarction trial American Heart Journal  1990 119:777-785  DOI:10.1016/s0002-8703(05)80311-4  PMID:2108575
  • Sutton, J. M., Topol, E. J. Usefulness of coronary-artery angioplasty strategies in acute myocardial-infarction Canadian Journal of Cardiology  1990 6:111-122  PMID:2187576
  • Muller, D. W. M., Topol, E. J., Califf, R. M., Sigmon, K. N., Gorman, L., George, B. S., Kereiakes, D. J., Lee, K. L., Ellis, S. G. Relationship between antecedent angina-pectoris and short-term prognosis after thrombolytic therapy for acute myocardial-infarction American Heart Journal  1990 119:224-231  DOI:10.1016/s0002-8703(05)80008-0  PMID:2405608
  • Kander, N. H., Holland, K. J., Pitt, B., Topol, E. J. A randomized pilot trial of brief versus prolonged heparin after successful reperfusion in acute myocardial-infarction American Journal of Cardiology  1990 65:139-142  DOI:10.1016/0002-9149(90)90074-b  PMID:2404389
  • Popma, J. J., Topol, E. J. Factors influencing restenosis after coronary angioplasty American Journal of Medicine  1990 88:N16-N24
  • Vogel, R. A., Shawl, F., Tommaso, C., Oneill, W., Overlie, P., Otoole, J., Vandormael, M., Topol, E., Tabari, K. K., Vogel, J., Smith, S., Freedmann, R., et al. Initial report of the national-registry-of-elective-cardiopulmonary bypass supported coronary angioplasty Journal of the American College of Cardiology  1990 15:23-29  PMID:2404047
  • Ellis, S. G., Muller, D. W., Topol, E. J. Possible survival benefit from concomitant beta-antagonist but not calcium-antagonist therapy during reperfusion for acute myocardial-infarction American Journal of Cardiology  1990 66:125-128  DOI:10.1016/0002-9149(90)90574-k  PMID:1973588
  • Muller, D. W. M., Topol, E. J. Unresolved issues: late reperfusion, lytic failure, and reocclusion Coronary Artery Disease  1990 1:39-49  DOI:10.1097/00019501-199001000-00007
  • Sane, D. C., Califf, R. M., Topol, E. J., Stump, D. C., Mark, D. B., Greenberg, C. S. Bleeding during thrombolytic therapy for acute myocardial-infarction - mechanisms and management Annals of Internal Medicine  1989 111:1010-1022  PMID:2688504
  • Holmes, D. R., Topol, E. J. Reperfusion momentum - lessons from the randomized trials of immediate coronary angioplasty for myocardial-infarction Journal of the American College of Cardiology  1989 14:1572-1578  DOI:10.1016/0735-1097(89)90401-4  PMID:2809019
  • Burek, K. A., Kirscht, J., Topol, E. J. Exercise capacity in patients 3 days after acute, uncomplicated myocardial-infarction Heart & Lung  1989 18:575-582  PMID:2684916
  • Califf, R. M., Topol, E. J., Gersh, B. J. From myocardial salvage to patient salvage in acute myocardial-infarction - the role of reperfusion therapy Journal of the American College of Cardiology  1989 14:1382-1388  DOI:10.1016/0735-1097(89)90445-2  PMID:2681322
  • Stump, D. C., Califf, R. M., Topol, E. J., Sigmon, K., Thornton, D., Masek, R., Anderson, L., Collen, D. Pharmacodynamics of thrombolysis with recombinant tissue-type plasminogen-activator - correlation with characteristics of and clinical outcomes in patients with acute myocardial-infarction Circulation  1989 80:1222-1230  PMID:2509104
  • Ellis, S. G., Topol, E. J., George, B. S., Kereiakes, D. J., Debowey, D., Sigmon, K. N., Pickel, A., Lee, K. L., Califf, R. M. Recurrent ischemia without warning - analysis of risk-factors for in-hospital ischemic events following successful thrombolysis with intravenous tissue plasminogen-activator Circulation  1989 80:1159-1165  PMID:2509102
  • Gacioch, G. M., Topol, E. J. Sudden paradoxic clinical deterioration during angioplasty of the occluded right coronary-artery in acute myocardial-infarction Journal of the American College of Cardiology  1989 14:1202-1209  DOI:10.1016/0735-1097(89)90418-x  PMID:2808974
  • Chapekis, A. T., Burek, K., Topol, E. J. The cost-benefit ratio of acute intervention for myocardial-infarction - results of a prospective, matched pair analysis American Heart Journal  1989 118:878-882  DOI:10.1016/0002-8703(89)90217-2  PMID:2510487
  • Topol, E. J., Ellis, S. G., Califf, R. M., George, B. S., Stump, D. C., Bates, E. R., Nabel, E. G., Walton, J. A., Candela, R. J., Lee, K. L., Kline, E. M., Pitt, B. Combined tissue-type plasminogen-activator and prostacyclin therapy for acute myocardial-infarction Journal of the American College of Cardiology  1989 14:877-884  PMID:2477426
  • Ellis, S. G., Shaw, R. E., King, S. B., Myler, R. K., Topol, E. J. Restenosis after excellent angiographic angioplasty result for chronic total coronary-artery occlusion - implications for newer percutaneous revascularization devices American Journal of Cardiology  1989 64:667-668  DOI:10.1016/0002-9149(89)90500-6  PMID:2528903
  • Muller, D. W. M., Topol, E. J. Acute myocardial infarction: early and late percutaneous trans-luminal coronary angioplasty Current Opinion in Cardiology  1989 4:524-530  DOI:10.1097/00001573-198908000-00012
  • Kereiakes, D. J., Topol, E. J., George, B. S., Abbottsmith, C. W., Stack, R. S., Candela, R. J., Oneill, W. W., Anderson, L. C., Califf, R. M. Favorable early and long-term prognosis following coronary-bypass surgery therapy for myocardial-infarction - results of a multicenter trial American Heart Journal  1989 118:199-207  DOI:10.1016/0002-8703(89)90177-4  PMID:2526573
  • Kander, N. H., Oneill, W., Topol, E. J., Gallison, L., Mileski, R., Ellis, S. G. Long-term follow-up of patients treated with coronary angioplasty for acute myocardial-infarction American Heart Journal  1989 118:228-233  DOI:10.1016/0002-8703(89)90180-4  PMID:2526574
  • Grines, C. L., Topol, E. J., Califf, R. M., Stack, R. S., George, B. S., Kereiakes, D., Boswick, J. M., Kline, E., Oneill, W. W. Prognostic implications and predictors of enhanced regional wall motion of the noninfarct zone after thrombolysis and angioplasty therapy of acute myocardial-infarction Circulation  1989 80:245-253  PMID:2526697
  • Muller, D. W. M., Ellis, S. G., Topol, E. J. Atherectomy of the left main coronary-artery with percutaneous cardiopulmonary bypass support American Journal of Cardiology  1989 64:114-116  DOI:10.1016/0002-9149(89)90668-1  PMID:2787097
  • Bates, E. R., Topol, E. J. Early hospital discharge in the myocardial reperfusion era Clinical Cardiology  1989 12:65-70  PMID:2691143
  • Topol, E. J. Recombinant tissue plasminogen-activator - implications in therapy Seminars in Hematology  1989 26:25-31
  • Ellis, S. G., Oneill, W. W., Bates, E. R., Walton, J. A., Nabel, E. G., Werns, S. W., Topol, E. J. Implications for patient triage from survival and left-ventricular functional recovery analyses in 500 patients treated with coronary angioplasty for acute myocardial-infarction Journal of the American College of Cardiology  1989 13:1251-1259  PMID:2522954
  • Ellis, S. G., Topol, E. J. Intracoronary stents - will they fulfill their promise as an adjunct to angioplasty Journal of the American College of Cardiology  1989 13:1425-1430  PMID:2522960
  • Ellis, S. G., Shaw, R. E., Gershony, G., Thomas, R., Roubin, G. S., Douglas, J. S., Topol, E. J., Startzer, S. H., Myler, R. K., King, S. B. Risk-factors, time course and treatment effect for restenosis after successful percutaneous trans-luminal coronary angioplasty of chronic total occlusion American Journal of Cardiology  1989 63:897-901  DOI:10.1016/0002-9149(89)90135-5  PMID:2522727
  • Loscalzo, J., Wharton, T. P., Kirshenbaum, J. M., Levine, H. J., Flaherty, J. T., Topol, E. J., Ramaswamy, K., Kosowsky, B. D., Salem, D. N., Ganz, P., Brinker, J. A., Gurewich, V., et al. Clot-selective coronary thrombolysis with pro-urokinase Circulation  1989 79:776-782  PMID:2494004
  • Ellis, S. G., Oneill, W. W., Bates, E. R., Walton, J. A., Nabel, E. G., Topol, E. J. Coronary angioplasty as primary therapy for acute myocardial-infarction 6 to 48 hours after symptom onset - report of an initial experience Journal of the American College of Cardiology  1989 13:1122-1126  PMID:2522467
  • Holland, K. J., Oneill, W. W., Bates, E. R., Pitt, B., Topol, E. J. Emergency percutaneous trans-luminal coronary angioplasty during acute myocardial-infarction for patients more than 70 years of age American Journal of Cardiology  1989 63:399-403  DOI:10.1016/0002-9149(89)90307-x  PMID:2521765
  • Topol, E. J., George, B. S., Kereiakes, D. J., Stump, D. C., Candela, R. J., Abbottsmith, C. W., Aronson, L., Pickel, A., Boswick, J. M., Lee, K. L., Ellis, S. G., Califf, R. M. A randomized controlled trial of intravenous tissue plasminogen-activator and early intravenous heparin in acute myocardial-infarction Circulation  1989 79:281-286  PMID:2492454
  • Ellis, S. G., Gallison, L., Grines, C. L., Langburd, A. B., Bates, E. R., Walton, J. A., Oneill, W. W., Topol, E. J. Incidence and predictors of early recurrent ischemia after successful percutaneous trans-luminal coronary angioplasty for acute myocardial-infarction American Journal of Cardiology  1989 63:263-268  DOI:10.1016/0002-9149(89)90327-5  PMID:2521536
  • Nicklas, J. M., Topol, E. J., Kander, N., Oneill, W. W., Walton, J. A., Ellis, S. G., Gorman, L., Pitt, B. Randomized, double-blind, placebo-controlled trial of tissue plasminogen-activator in unstable angina Journal of the American College of Cardiology  1989 13:434-441  PMID:2492325
  • Bates, E. R., Califf, R. M., Stack, R. S., Aronson, L., George, B. S., Candela, R. J., Kereiakes, D. J., Abbottsmith, C. W., Anderson, L., Pitt, B., Oneill, W. W., Topol, E. J. Thrombolysis and angioplasty in myocardial-infarction (tami-1) trial - influence of infarct location on arterial patency, left-ventricular function and mortality Journal of the American College of Cardiology  1989 13:12-18  PMID:2521226
  • Topol, E. J. Coronary angioplasty for acute myocardial-infarction Annals of Internal Medicine  1988 109:970-978  PMID:2973762
  • Steinberg, E. P., Topol, E. J., Sakin, J. W., Kahane, S. N., Appel, L. J., Powe, N. R., Anderson, G. F., Erickson, J. E., Guerci, A. D. Cost and procedure implications of thrombolytic therapy for acute myocardial-infarction Journal of the American College of Cardiology  1988 12:A58-A68
  • Topol, E. J., Califf, R. M., George, B. S., Kereiakes, D. J., Lee, K. L. Insights derived from the thrombolysis and angioplasty in myocardial-infarction (tami) trials Journal of the American College of Cardiology  1988 12:A24-A31
  • Ellis, S. G., Topol, E. J., Gallison, L., Grines, C. L., Langburd, A. B., Bates, E. R., Walton, J. A., Oneill, W. W. Predictors of success for coronary angioplasty performed for acute myocardial-infarction Journal of the American College of Cardiology  1988 12:1407-1415  PMID:2973481
  • Carlson, S. E., Aldrich, M. S., Greenberg, H. S., Topol, E. J. Intracerebral hemorrhage complicating intravenous tissue plasminogen-activator treatment Archives of Neurology  1988 45:1070-1073  PMID:3140769
  • Grines, C. L., Oneill, W. W., Anselmo, E. G., Juni, J. E., Topol, E. J. Comparison of left-ventricular function and contractile reserve after successful recanalization by thrombolysis versus rescue percutaneous trans-luminal coronary angioplasty for acute myocardial-infarction American Journal of Cardiology  1988 62:352-357  DOI:10.1016/0002-9149(88)90957-5  PMID:2970774
  • Topol, E. J., Nicklas, J. M., Kander, N. H., Walton, J. A., Ellis, S. G., Gorman, L., Pitt, B. Coronary revascularization after intravenous tissue plasminogen-activator for unstable angina-pectoris - results of a randomized, double-blind, placebo-controlled trial American Journal of Cardiology  1988 62:368-371  DOI:10.1016/0002-9149(88)90960-5  PMID:2970776
  • Califf, R. M., Topol, E. J., George, B. S., Boswick, J. M., Abbottsmith, C., Sigmon, K. N., Candela, R., Masek, R., Kereiakes, D., Oneill, W. W., Stack, R. S., Stump, D. Hemorrhagic complications associated with the use of intravenous tissue plasminogen-activator in treatment of acute myocardial-infarction American Journal of Medicine  1988 85:353-359  DOI:10.1016/0002-9343(88)90586-4  PMID:3137818
  • Topol, E. J. An overview of the thrombolysis and angioplasty in acute myocardial infarction (TAMI) trials Archives Des Maladies Du Coeur Et Des Vaisseaux  1988 81:45-49  PMID:2973302
  • Califf, R. M., Topol, E. J., George, B. S., Boswick, J. M., Lee, K. L., Stump, D., Dillon, J., Abbottsmith, C., Candela, R. J., Kereiakes, D. J., Oneill, W. W., Stack, R. S. Characteristics and outcome of patients in whom reperfusion with intravenous tissue-type plasminogen-activator fails - results of the thrombolysis and angioplasty in myocardial-infarction (tami) i-trial Circulation  1988 77:1090-1099  PMID:2966016
  • Topol, E. J., Califf, R. M., George, B. S., Kereiakes, D. J., Rothbaum, D., Candela, R. J., Abbotsmith, C. W., Pinkerton, C. A., Stump, D. C., Collen, D., Lee, K. L., Pitt, B., et al. Coronary arterial thrombolysis with combined infusion of recombinant tissue-type plasminogen-activator and urokinase in patients with acute myocardial-infarction Circulation  1988 77:1100-1107  PMID:2966017
  • Kereiakes, D. J., Topol, E. J., George, B. S., Abbottsmith, C. W., Stack, R. S., Candela, R. J., Oneill, W. W., Martin, L. H., Califf, R. M. Emergency coronary-artery bypass-surgery preserves global and regional left-ventricular function after intravenous tissue plasminogen-activator therapy for acute myocardial-infarction Journal of the American College of Cardiology  1988 11:899-907  PMID:2965716
  • Califf, R. M., Oneil, W., Stack, R. S., Aronson, L., Mark, D. B., Mantell, S., George, B. S., Candela, R. J., Kereiakes, D. J., Abbottsmith, C., Topol, E. J. Failure of simple clinical measurements to predict perfusion status after intravenous thrombolysis Annals of Internal Medicine  1988 108:658-662  PMID:3128953
  • Topol, E. J., Burek, K., Oneill, W. W., Kewman, D. G., Kander, N. H., Shea, M. J., Schork, M. A., Kirscht, J., Juni, J. E., Pitt, B. A randomized controlled trial of hospital discharge 3 days after myocardial-infarction in the era of reperfusion New England Journal of Medicine  1988 318:1083-1088  DOI:10.1056/nejm198804283181702  PMID:3281014
  • Stump, D. C., Topol, E. J., Chen, A. B., Hopkins, A., Collen, D. Monitoring of hemostasis parameters during coronary thrombolysis with recombinant tissue-type plasminogen-activator Thrombosis and Haemostasis  1988 59:133-137  PMID:2455358
  • Topol, E. J., George, B. S., Kereiakes, D. J., Candela, R. J., Abbottsmith, C. W., Stump, D. C., Boswick, J. M., Stack, R. S., Califf, R. M. Comparison of 2 dose regimens of intravenous tissue plasminogen-activator for acute myocardial-infarction American Journal of Cardiology  1988 61:723-728  DOI:10.1016/0002-9149(88)91055-7  PMID:2965504
  • Humphrey, L. S., Topol, E. J., Rosenfeld, G. I., Borkon, A. M., Baumgartner, W. A., Gardner, T. J., Maruschak, G., Weiss, J. L. Immediate enhancement of left-ventricular relaxation by coronary-artery bypass-grafting - intraoperative assessment Circulation  1988 77:886-896  PMID:3258195
  • Grines, C. L., Topol, E. J., Bates, E. R., Juni, J. E., Walton, J. A., Oneill, W. W. Infarct vessel status after intravenous tissue plasminogen-activator and acute coronary angioplasty - prediction of clinical outcome American Heart Journal  1988 115:1-7  DOI:10.1016/0002-8703(88)90510-8  PMID:2962478
  • Oneill, W. W., Topol, E. J., Pitt, B. Reperfusion therapy of acute myocardial-infarction Progress in Cardiovascular Diseases  1988 30:235-266  DOI:10.1016/0033-0620(88)90018-7  PMID:3275989
  • Guerci, A. D., Gerstenblith, G., Brinker, J. A., Chandra, N. C., Gottlieb, S. O., Bahr, R. D., Weiss, J. L., Shapiro, E. P., Flaherty, J. T., Bush, D. E., Chew, P. H., Gottlieb, S. H., et al. A randomized trial of intravenous tissue plasminogen-activator for acute myocardial-infarction with subsequent randomization to elective coronary angioplasty New England Journal of Medicine  1987 317:1613-1618  DOI:10.1056/nejm198712243172601  PMID:2960897
  • Topol, E. J., Bates, E. R., Walton, J. A., Baumann, G., Wolfe, S., Maino, J., Bayer, L., Gorman, L., Kline, E. M., Oneill, W. W., Pitt, B. Community-hospital administration of intravenous tissue plasminogen-activator in acute myocardial-infarction - improved timing, thrombolytic efficacy and ventricular-function Journal of the American College of Cardiology  1987 10:1173-1177  PMID:3119685
  • Topol, E. J. Acute intervention for myocardial-infarction Chest  1987 92:929-932  DOI:10.1378/chest.92.5.929  PMID:2959455
  • Topol, E. J. Clinical use of streptokinase and urokinase therapy for acute myocardial-infarction Heart & Lung  1987 16:760-774  PMID:3316129
  • Topol, E. J., Juni, J. E., Oneill, W. W., Nicklas, J. M., Shea, M. J., Burek, K., Pitt, B. Exercise testing 3 days after onset of acute myocardial-infarction American Journal of Cardiology  1987 60:958-962  DOI:10.1016/0002-9149(87)90332-8  PMID:2960230
  • Topol, E. J., Califf, R. M., Kereiakes, D. J., George, B. S. Thrombolysis and angioplasty in myocardial-infarction (tami) trial Journal of the American College of Cardiology  1987 10:B65-B74