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  • Topol, E. Bad blood secrets and lies in a Silicon Valley startup Nature  2018 557:306-307
  • Dharajiya, N. G., Grosu, D. S., Farkas, D. H., McCullough, R. M., Almasri, E., Sun, Y., Kim, S. K., Jensen, T. J., Saldivar, J. S., Topol, E. J., van den Boom, D., Ehrich, M. Incidental detection of maternal neoplasia in noninvasive prenatal testing Clinical Chemistry  2018 64:329-335  DOI:10.1373/clinchem.2017.277517  PMID:28982650
  • Jha, S., Topol, E. J. Information and artificial intelligence Journal of the American College of Radiology  2018 15:509-511  DOI:10.1016/j.jacr.2017.12.025
  • Mikk, K. A., Sleeper, H. A., Topol, E. Patient data ownership reply JAMA-Journal of the American Medical Association  2018 319:935-936  DOI:10.1001/jama.2017.21688  PMID:29509862
  • Kim, K. I., Nikzad, N., Quer, G., Wineinger, N. E., Vegreville, M., Normand, A., Schmidt, N., Topol, E. J., Steinhubl, S. Real world home blood pressure variability in over 56,000 individuals with nearly 17 million measurements American Journal of Hypertension  2018 31:566-573  DOI:10.1093/ajh/hpx221  PMID:29365036  PMCID:PMC5905665
  • Telenti, A., Steinhubl, S. R., Topol, E. J. Rethinking the medical record Lancet  2018 391:1013-1013  PMID:29565009
  • Muse, E. D., Wineinger, N. E., Spencer, E. G., Peters, M., Henderson, R., Zhang, Y., Barrett, P. M., Rivera, S. P., Wohlgemuth, J. G., Devlin, J. J., Shiffman, D., Topol, E. J. Validation of a genetic risk score for atrial fibrillation: A prospective multicenter cohort study PLoS Medicine  2018 15  DOI:10.1371/journal.pmed.1002525  PMID:29534064  PMCID:PMC5849279
  • Steinhubl, S. R., Kim, K. I., Ajayi, T., Topol, E. J. Virtual care for improved global health Lancet  2018 391:419-419  PMID:29407024
  • Muse, E. D., Kramer, E. R., Wang, H. Y., Barrett, P., Parviz, F., Novotny, M. A., Lasken, R. S., Jatkoe, T. A., Oliveira, G., Peng, H. F., Lu, J., Connelly, M. C., et al. A whole blood molecular signature for acute myocardial infarction Scientific Reports  2017 7  DOI:10.1038/s41598-017-12166-0  PMID:28947747  PMCID:PMC5612952
  • Quer, G., Muse, E. D., Nikzad, N., Topol, E. J., Steinhubl, S. R. Digital medicine: Augmenting diagnostic vision with AI Lancet  2017 390:221-221
  • Barrett, P. M., Steinhubl, S. R., Muse, E. D., Topol, E. J. Digitising the mind Lancet  2017 389:1877-1877  PMID:28513442
  • Guo, Y., Wang, F., Li, L., Gao, H., Arckacki, S., Wang, I. Z., Barnard, J., Ellis, S., Hubbard, C., Topol, E. J., Chen, Q., Wang, Q. K. Genome-wide linkage analysis of large multiple multigenerational families identifies novel genetic loci for coronary rrtery disease Scientific Reports  2017 7  DOI:10.1038/s41598-017-05381-2  PMID:28710368  PMCID:PMC5511258
  • Torkamani, A., Andersen, K. G., Steinhubl, S. R., Topol, E. J. High-Definition Medicine Cell  2017 170:828-843  DOI:10.1016/j.cell.2017.08.007  PMID:28841416
  • Lo Sardo, V., Ferguson, W., Erikson, G. A., Topol, E. J., Baldwin, K. K., Torkamani, A. Influence of donor age on induced pluripotent stem cells Nature Biotechnology  2017 35:69-74  DOI:10.1038/nbt.3749  PMID:27941802
  • Topol, E. J. Is there an ICD-10 code for hyperbole? JAMA-Journal of the American Medical Association  2017 317:10-11  PMID:28030677
  • Bansal, V., Gassenhuber, J., Phillips, T., Oliveira, G., Harbaugh, R., Villarasa, N., Topol, E. J., Seufferlein, T., Boehm, B. O. Spectrum of mutations in monogenic diabetes genes identified from high-throughput DNA sequencing of 6888 individuals BMC Medicine  2017 15  DOI:10.1186/s12916-017-0977-3  PMID:29207974  PMCID:PMC5717832
  • Steinhubl, S. R., McGovern, P., Dylan, J., Topol, E. J. The digitised clinical trial Lancet  2017 390:2135-2135  PMID:29143747
  • Mikk, K. A., Sleeper, H. A., Topol, E. J. The pathway to patient data ownership and better health JAMA-Journal of the American Medical Association  2017 318:1433-1434  DOI:10.1001/jama.2017.12145  PMID:28973063
  • Muse, E. D., Barrett, P. M., Steinhubl, S. R., Topol, E. J. Towards a smart medical home Lancet  2017 389:358-358  PMID:28137686
  • Gollamudi, S. S., Topol, E. J., Wineinger, N. E. A framework for smartphone-enabled, patient-generated health data analysis PeerJ  2016 4  DOI:10.7717/peerj.2284  PMID:27547580  PMCID:PMC4975026
  • Radin, J. M., Topol, E. J., Andersen, K. G., Steinhubl, S. R. A laboratory in your pocket Lancet  2016 388:1875-1875  PMID:27751390
  • Bloss, C. S., Wineinger, N. E., Peters, M., Boeldt, D. L., Ariniello, L., Kim, J. Y., Sheard, J., Komatireddy, R., Barrett, P., Topol, E. J. A prospective randomized trial examining health care utilization in individuals using multiple smartphone-enabled biosensors PeerJ  2016 4  DOI:10.7717/peerj.1554  PMID:26788432  PMCID:PMC4715435
  • Jha, S., Topol, E. J. Adapting to artificial intelligence radiologists and pathologists as information specialists JAMA-Journal of the American Medical Association  2016 316:2353-2354  DOI:10.1001/jama.2016.17438  PMID:27898975
  • Topol, E. Digital medicine: empowering both patients and clinicians Lancet  2016 388:740-741  PMID:27560260
  • Torkamani, A., Muse, E. D., Spencer, E. G., Rueda, M., Wagner, G. N., Lucas, J. R., Topol, E. J. Molecular autopsy for sudden unexpected death JAMA-Journal of the American Medical Association  2016 316:1492-1494  PMID:27727376
  • Topol, E. J. Money back guarantees for non-reproducible results? BMJ-British Medical Journal  2016 353  DOI:10.1136/bmj.i2770  PMID:27221803
  • Steinhubl, S. R., Muse, E. D., Barrett, P. M., Topol, E. J. Off the cuff : rebooting blood pressure treatment Lancet  2016 388:749-749  PMID:27560266
  • Filkins, B. L., Kim, J. Y., Roberts, B., Armstrong, W., Miller, M. A., Hultner, M. L., Castillo, A. P., Ducom, J. C., Topol, E. J., Steinhubl, S. R. Privacy and security in the era of digital health: what should translational researchers know and do about it? American Journal of Translational Research  2016 8:1560-1580  PMID:27186282  PMCID:PMC4859641
  • Steinhubl, S. R., Mehta, R. R., Ebner, G. S., Ballesteros, M. M., Waalen, J., Steinberg, G., Van Crocker Jr., P., Felicione, E., Carter, C. T., Edmonds, S., Honcz, J. P., Miralles, G. D., et al. Rationale and design of a home-based trial using wearable sensors to detect asymptomatic atrial fibrillation in a targeted population: The mHealth Screening To Prevent Strokes (mSToPS) trial American Heart Journal  2016 175:77-85  DOI:10.1016/j.ahj.2016.02.011  PMID:27179726
  • Kim, J. Y., Wineinger, N. E., Taitel, M., Radin, J. M., Akinbosoye, O., Jiang, J., Nikzad, N., Orr, G., Topol, E., Steinhubl, S. Self-monitoring utilization patterns among individuals in an incentivized program for healthy behaviors Journal of Medical Internet Research  2016 18:83-97  DOI:10.2196/jmir.6371  PMID:27856407
  • Barrett, P. M., Topol, E. J. Smartphone Medicine It Professional  2016 18:52-54
  • Dorsey, E. R., Topol, E. J. State of Telehealth REPLY New England Journal of Medicine  2016 375:1400-1400
  • Dorsey, E. R., Topol, E. J. State of telehealth New England Journal of Medicine  2016 375:154-161  DOI:10.1056/NEJMra1601705  PMID:27410924
  • Wilbanks, J. T., Topol, E. J. Stop the privatization of health data Nature  2016 535:345-348  PMID:27443724
  • Topol, E. The evangelist of individualized medicine Technology Review  2016 119:91-92
  • Barrett, P. M., Topol, E. J. To truly look inside Lancet  2016 387:1268-1269  PMID:27035018
  • Erikson, G. A., Bodian, D. L., Rueda, M., Molparia, B., Scott, E. R., Scott-Van Zeeland, A. A., Topol, S. E., Wineinger, N. E., Niederhuber, J. E., Topol, E. J., Torkamani, A. Whole-genome sequencing of a healthy aging cohort Cell  2016 165:1002-1011  DOI:10.1016/j.cell.2016.03.022  PMID:27114037  PMCID:PMC4860090
  • Guillot, J., Topol, E., Brynjolfsson, E. Fighting for Zach Technology Review  2015 118:10-11
  • Topol, E. Watch This Technology Review  2015 118:11-11
  • Bloss, C. S., Zeeland, A. A. S. V., Topol, S. E., Darst, B. F., Boeldt, D. L., Erikson, G. A., Bethel, K. J., Bjork, R. L., Friedman, J. R., Hwynn, N., Patay, B. A., Pockros, P. J., et al. A genome sequencing program for novel undiagnosed diseases Genetics in Medicine  2015 17:995-1001  DOI:10.1038/gim.2015.21  PMID:25790160  PMCID:PMC4575596
  • Steinhubl, S. R., Wineingeri, N. E., Patel, S., Boeldt, D. L., Mackellar, G., Porter, V., Redmond, J. T., Muse, E. D., Nicholson, L., Chopra, D., Topol, E. J. Cardiovascular and nervous system changes during meditation Frontiers in Human Neuroscience  2015 9  DOI:10.3389/fnhum.2015.00145  PMID:25852526  PMCID:PMC4364161
  • Topol, E. J., Steinhubl, S. R., Torkamani, A. Digital medical tools and sensors JAMA-Journal of the American Medical Association  2015 313:353-354  DOI:10.1001/jama.2014.17125  PMID:25626031  PMCID:PMC4751024
  • Rifai, N., Topol, E., Chan, E., Lo, Y. M. D., Wittwer, C. T. Disruptive innovation in laboratory medicine Clinical Chemistry  2015 61:1129-1132  DOI:10.1373/clinchem.2015.243667  PMID:26152753
  • Boeldt, D. L., Wineinger, N. E., Waalen, J., Gollamudi, S., Grossberg, A., Steinhubl, S. R., McCollister-Slipp, A., Rogers, M. A., Silvers, C., Topol, E. J. How consumers and physicians view new medical technology: comparative survey Journal of Medical Internet Research  2015 17:e215  DOI:10.2196/jmir.4456  PMID:26369254  PMCID:PMC4642377
  • Boeldt, D. L., Schork, N. J., Topol, E. J., Bloss, C. S. Influence of individual differences in disease perception on consumer response to direct-to-consumer genomic testing Clinical Genetics  2015 87:225-232  DOI:10.1111/cge.12419  PMID:24798746  PMCID:PMC4758676
  • Teirstein, P., Topol, E. J. Maintenance of certification and the interstate medical licensure compact reply JAMA-Journal of the American Medical Association  2015 314:952-952  PMID:26325571
  • Steinhubl, S. R., Topol, E. J. Moving from digitalization to digitization in cardiovascular care why is it important, and what could it mean for patients and providers? Journal of the American College of Cardiology  2015 66:1489-1496  DOI:10.1016/j.jacc.2015.08.006  PMID:26403346  PMCID:PMC4583658
  • Braenne, I., Civelek, M., Vilne, B., Di Narzo, A., Johnson, A. D., Zhao, Y., Reiz, B., Codoni, V., Webb, T. R., Asl, H. F., Hamby, S. E., Zeng, L., et al. Prediction of causal candidate genes in coronary artery disease loci Arteriosclerosis Thrombosis and Vascular Biology  2015 35:2207-2217  DOI:10.1161/atvbaha.115.306108  PMID:26293461  PMCID:PMC4583353
  • Harper, A. R., Nayee, S., Topol, E. J. Protective alleles and modifier variants in human health and disease Nature Reviews Genetics  2015 16:689-701  DOI:10.1038/nrg4017  PMID:26503796
  • Topol, E. J. The big medical data miss: challenges in establishing an open medical resource Nature Reviews Genetics  2015 16:253-254  DOI:10.1038/nrg3943  PMID:25882108
  • Steinhubl, S. R., Muse, E. D., Topol, E. J. The emerging field of mobile health Science Translational Medicine  2015 7  DOI:10.1126/scitranslmed.aaa3487  PMID:25877894  PMCID:PMC4748838
  • Teirstein, P. S., Topol, E. J. The role of maintenance of certification programs in governance and professionalism JAMA-Journal of the American Medical Association  2015 313:1809-1810  DOI:10.1001/jama.2015.3576  PMID:25965219  PMCID:PMC4751049
  • Lauer, M. S., Krumholz, H. M., Topol, E. J. Time for a prepublication culture in clinical research? Lancet  2015 386:2447-2449  DOI:10.1016/S0140-6736(15)01177-0  PMID:26738703  PMCID:PMC5082701
  • Kish, L. J., Topol, E. J. Unpatients-why patients should own their medical data Nature Biotechnology  2015 33:921-924  PMID:26348958
  • Shen, G. Q., Girelli, D., Li, L., Rao, S., Archacki, S., Olivieri, O., Martinelli, N., Park, J. E., Chen, Q., Topol, E. J., Wang, Q. K. A novel molecular diagnostic marker for familial and early-onset coronary artery disease and myocardial infarction in the LRP8 gene Circulation-Cardiovascular Genetics  2014 7:514-520  DOI:10.1161/circgenetics.113.000321  PMID:24867879  PMCID:PMC4140990
  • Khan, H. A., Wineinger, N. E., Uddin, P. Q., Mehta, H. S., Rubenson, D. S., Topol, E. J. Can hospital rounds with pocket ultrasound by cardiologists reduce standard echocardiography? American Journal of Medicine  2014 127:669.e1-669.e7  DOI:10.1016/j.amjmed.2014.03.015  PMID:24674919  PMCID:PMC4074438
  • Barrett, P. M., Komatireddy, R., Haaser, S., Topol, S., Sheard, J., Encinas, J., Fought, A. J., Topol, E. J. Comparison of 24-hour Holter monitoring with 14-day novel adhesive patch electrocardiographic monitoring American Journal of Medicine  2014 127:95.e11  DOI:10.1016/j.amjmed.2013.10.003  PMID:24384108  PMCID:PMC3882198
  • Bloss, C. S., Schork, N. J., Topol, E. J. Direct-to-consumer pharmacogenomic testing is associated with increased physician utilisation Journal of Medical Genetics  2014 51:83-89  DOI:10.1136/jmedgenet-2013-101909  PMID:24343916
  • Scott-Van Zeeland, A. A., Bloss, C. S., Tewhey, R., Bansal, V., Torkamani, A., Libiger, O., Duvvuri, V., Wineinger, N., Galvez, L., Darst, B. F., Smith, E. N., Carson, A., et al. Evidence for the role of EPHX2 gene variants in anorexia nervosa Molecular Psychiatry  2014 19:724-732  DOI:10.1038/mp.2013.91  PMID:23999524  PMCID:PMC3852189
  • Bethel, K., Luttgen, M. S., Damani, S., Kolatkar, A., Lamy, R., Sabouri-Ghomi, M., Topol, S., Topol, E. J., Kuhn, P. Fluid phase biopsy for detection and characterization of circulating endothelial cells in myocardial infarction Physical Biology  2014 11:016002  DOI:10.1088/1478-3975/11/1/016002  PMID:24406475  PMCID:PMC4143170
  • Chen, Y. Z., Friedman, J. R., Chen, D. H., Chan, G. C. K., Bloss, C. S., Hisama, F. M., Topol, S. E., Carson, A. R., Pham, P. H., Bonkowski, E. S., Scott, E. R., Lee, J. K., et al. Gain-of-function ADCY5 mutations in familial dyskinesia with facial myokymia Annals of Neurology  2014 75:542-549  DOI:10.1002/ana.24119  PMID:24700542  PMCID:PMC4457323
  • Gao, H., Li, L., Rao, S., Shen, G., Xi, Q., Chen, S., Zhang, Z., Wang, K., Ellis, S. G., Chen, Q., Topol, E. J., Wang, Q. K. Genome-wide linkage scan identifies two novel genetic loci for coronary artery disease: in GeneQuest families PLoS One  2014 9:e113935  DOI:10.1371/journal.pone.0113935  PMID:25485937  PMCID:PMC4259362
  • Steinhubl, S. R., Muse, E. D., Topol, E. J. Implementation of mobile health tools. Reply JAMA-Journal of the American Medical Association  2014 311:1448-1449  DOI:10.1001/jama.2014.1112  PMID:24715085
  • Topol, E. J. Individualized medicine from prewomb to tomb Cell  2014 157:241-253  DOI:10.1016/j.cell.2014.02.012  PMID:24679539  PMCID:PMC3995127
  • Walsh III, J. A., Topol, E. J., Steinhubl, S. R. Novel wireless devices for cardiac monitoring Circulation  2014 130:573-581  DOI:10.1161/circulationaha.114.009024  PMID:25114186  PMCID:PMC4135373
  • Tang, W. H. W., Topol, E. J., Fan, Y., Wu, Y., Cho, L., Stevenson, C., Ellis, S. G., Hazen, S. L. Prognostic value of estimated functional capacity incremental to cardiac biomarkers in stable cardiac patients Journal of the American Heart Association  2014 3:e000960  DOI:10.1161/jaha.114.000960
  • Steinhubl, S. R., Topol, E. J. RESPONSE: Time for the pager to enter retirement Journal of the American College of Cardiology  2014 64:2705-2705
  • Cruchaga, C., Karch, C. M., Jin, S. C., Benitez, B. A., Cai, Y., Guerreiro, R., Harari, O., Norton, J., Budde, J., Bertelsen, S., Jeng, A. T., Cooper, B., et al. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease Nature  2014 505:550-554  DOI:10.1038/nature12825  PMID:24336208  PMCID:PMC4050701
  • Goldberg, R., Kauffman, S., Topol, E. J. Study design and the drug development process JAMA-Journal of the American Medical Association  2014 311:2023-2023  DOI:10.1001/jama.2014.3826  PMID:24846044
  • Gaglani, S. M., Topol, E. J. iMedEd: the role of mobile health technologies in medical education Academic Medicine  2014 89:1207-1209  DOI:10.1097/acm.0000000000000361  PMID:24892404  PMCID:PMC4146691
  • Bloss, C. S., Wineinger, N. E., Darst, B. F., Schork, N. J., Topol, E. J. Impact of direct-to-consumer genomic testing at long term follow-up Journal of Medical Genetics  2013 393-400  DOI:10.1136/jmedgenet-2012-101207  PMID:23559530
  • Dunn, S. P., Steinhubl, S. R., Bauer, D., Charnigo, R. J., Berger, P. B., Topol, E. J. Impact of proton pump inhibitor therapy on the efficacy of clopidogrel in the CAPRIE and CREDO trials Journal of the American Heart Association  2013 2:e004564  DOI:10.1161/jaha.112.004564  PMID:23525436  PMCID:PMC3603228
  • Shen, G. Q., Girelli, D., Li, L., Olivieri, O., Martinelli, N., Chen, Q., Topol, E. J., Wang, Q. K. Multi-allelic haplotype association identifies novel information different from single-SNP analysis: A new protective haplotype in the LRP8 gene is against familial and early-onset CAD and MI Gene  2013 521:78-81  DOI:10.1016/j.gene.2013.03.022  PMID:23524007  PMCID:PMC3919654
  • Darst, B. F., Madlensky, L., Schork, N. J., Topol, E. J., Bloss, C. S. Perceptions of genetic counseling services in direct-to-consumer personal genomic testing Clinical Genetics  2013 84:335-339  DOI:10.1111/cge.12166  PMID:23590221
  • Goetz, L., Bethel, K., Topol, E. J. Rebooting cancer tissue handling in the sequencing era: Toward routine use of frozen tumor tissue JAMA-Journal of the American Medical Association  2013 309:37-38  PMID:23280221
  • Firstenberg, M. S., Dyke, C. M., Angiolillo, D. J., Ramaiahm, C., Price, M., Brtko, M., Welsby, I., Chandna, H., Holmes, D. R., Voeltz, M., Tummala, P., Hutyra, M., et al. Safety and efficacy of cangrelor, an intravenous, short-acting platelet inhibitor in patients requiring coronary artery bypass surgery Heart Surgery Forum  2013 16:E60-E69  DOI:10.1532/hsf98.20121103  PMID:23625478
  • Barrett, P. M., Topol, E. J. The fibrillin-1 gene: Unlocking new therapeutic pathways in cardiovascular disease Heart  2013 99:83-90  DOI:10.1136/heartjnl-2012-301840  PMID:22942299
  • Good, C. W., Steinhubl, S. R., Brennan, D. M., Lincoff, A. M., Topol, E. J., Berger, P. B. Is there a clinically significant interaction between calcium channel antagonists and clopidogrel?: results from the Clopidogrel for the Reduction of Events During Observation (CREDO) trial Circulation-Cardiovascular Interventions  2012 5:77-81  DOI:10.1161/circinterventions.111.963405  PMID:22319066
  • Lansky, A., Elashoff, M. R., Ng, V., McPherson, J., Lazar, D., Kraus, W. E., Voros, S., Schwartz, R. S., Topol, E. J., Investigators, Predict A gender-specific blood-based gene expression score for assessing obstructive coronary artery disease in nondiabetic patients: Results of the personalized risk evaluation and diagnosis in the coronary tree (predict) trial American Heart Journal  2012 164:320-326  DOI:10.1016/j.ahj.2012.05.012  PMID:22980297
  • Bloss, C. S., Topol, E. J., Schork, N. J. Association of direct-to-consumer genome-wide disease risk estimates and self-reported disease Genetic Epidemiology  2012 36:66-70  DOI:10.1002/gepi.20664  PMID:22127769  PMCID:PMC3338895
  • Angiolillo, D. J., Firstenberg, M. S., Price, M. J., Tummala, P. E., Hutyra, M., Welsby, I. J., Voeltz, M. D., Chandna, H., Ramaiah, C., Brtko, M., Cannon, L., Dyke, C., et al. Bridging antiplatelet therapy with cangrelor in patients undergoing cardiac surgery a randomized controlled trial JAMA-Journal of the American Medical Association  2012 307:265-274  DOI:10.1001/jama.2011.2002  PMID:22253393  PMCID:PMC3774162
  • Damani, S., Bacconi, A., Libiger, O., Chourasia, A. H., Serry, R., Gollapudi, R., Goldberg, R., Rapeport, K., Haaser, S., Topol, S., Knowlton, S., Bethel, K., et al. Characterization of circulating endothelial cells in acute myocardial infarction Science Translational Medicine  2012 4:126ra33  DOI:10.1126/scitranslmed.3003451  PMID:22440735  PMCID:PMC3589570
  • Archacki, S. R., Angheloiu, G., Moravec, C. S., Liu, H., Topol, E. J., Wang, Q. K. Comparative gene expression analysis between coronary arteries and internal mammary arteries identifies a role for the tes gene in endothelial cell functions relevant to coronary artery disease Human Molecular Genetics  2012 21:1364-1373  DOI:10.1093/hmg/ddr574  PMID:22156939
  • Mehta, R. H., Stebbins, A. S., Lopes, R. D., Califf, R. M., Pieper, K. S., Armstrong, P. W., Van de Werf, F., Hochman, J. S., White, H. D., Topol, E. J., Alexander, J. H., Granger, C. B. Comparison of incidence of bleeding and mortality of men versus women with st-elevation myocardial infarction treated with fibrinolysis American Journal of Cardiology  2012 109:320-326  DOI:10.1016/j.amjcard.2011.09.012  PMID:22078221
  • Barrett, P. M., Alagely, A., Topol, E. J. Cystic fibrosis in an era of genomically guided therapy Human Molecular Genetics  2012 21:R66-R71  DOI:10.1093/hmg/dds345  PMID:22914736
  • Geeganage, C. M., Diener, H. C., Algra, A., Chen, C., Topol, E. J., Dengler, R., Markus, H. S., Bath, M. W., Bath, P. M. W., Acute Antiplatelet Stroke, Trialist Dual or mono antiplatelet therapy for patients with acute ischemic stroke or transient ischemic attack: Systematic review and meta-analysis of randomized controlled trials Stroke  2012 43:1058-66  DOI:10.1161/strokeaha.111.637686  PMID:22282894
  • Tewhey, R., Cannavino, C. R., Leake, J. A. D., Bansal, V., Topol, E. J., Torkamani, A., Bradley, J. S., Schork, N. J. Genetic structure of community acquired methicillin-resistant Staphylococcus aureus USA300 BMC Genomics  2012 13:508  DOI:10.1186/1471-2164-13-508  PMID:23009684  PMCID:PMC3598774
  • Murray, S. S., Smith, E. N., Villarasa, N., Nahey, T., Lande, J., Goldberg, H., Shaw, M., Rosenthal, L., Ramza, B., Alaeddini, J., Han, X. Q., Damani, S., et al. Genome-wide association of implantable cardioverter-defibrillator activation with life-threatening arrhythmias PLoS One  2012 7:e25387  DOI:10.1371/journal.pone.0025387  PMID:22247754  PMCID:PMC3256134
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  • Topol, E. J., Califf, R. M., Lincoff, A. M., Tcheng, J. E., Cabot, C. F., Weisman, H. F., Kereiakes, D., Lausten, D., Runyon, J. P., Howard, W., Kelly, T., Muncy, D., et al. Platelet glycoprotein IIb/IIIa receptor blockade and low-dose heparin during percutaneous coronary revascularization New England Journal of Medicine  1997 336:1689-1696  PMID:9182212
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  • Tcheng, J. E., Lincoff, A. M., Sigmon, K. N., Lee, K. L., Kitt, M. M., Califf, R. M., Topol, E. J., Juran, N., Worley, S., Tuzi, J., Hollywood, L., Kleiman, N. S., et al. Randomised placebo-controlled trial of effect of eptifibatide on complications of percutaneous coronary intervention: IMPACT II Lancet  1997 349:1422-1428  PMID:9164315
  • Topol, E. J. Reperfusion for acute myocardial infarction: 1997 and beyond Cleveland Clinic Journal of Medicine  1997 64:9-12  PMID:9014377
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  • Lincoff, A. M., Tcheng, J. E., Califf, R. M., Bass, T., Popma, J. J., Teirstein, P. S., Kleiman, N. S., Hattel, L. J., Anderson, H. V., Ferguson, J. J., Cabot, C. F., Anderson, K. M., et al. Standard versus low-dose weight-adjusted heparin in patients treated with the platelet glycoprotein iib/iiia receptor antibody fragment abciximab (c7e3 fab) during percutaneous coronary revascularization American Journal of Cardiology  1997 79:286-291  PMID:9036746
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  • Lincoff, A. M., Furst, J. G., Ellis, S. G., Tuch, R. J., Topol, E. J. Sustained local delivery of dexamethasone by a novel intravascular eluting stent to prevent restenosis in the porcine coronary injury model Journal of the American College of Cardiology  1997 29:808-816  PMID:9091528
  • Forrester, J. S., Topol, E. J., Abele, J. E., Holmes, D. R., Skorton, D. J. Task force 5: Assessment, approval, and regulation of new technology Journal of the American College of Cardiology  1997 29:1171-1179  PMID:9137210
  • Barbagelata, N. A., Granger, C. B., Oqueli, E., Suarez, L. D., Borruel, M., Topol, E. J., Califf, R. M. Timi grade 3 flow and reocclusion after intravenous thrombolytic therapy: A pooled analysis American Heart Journal  1997 133:273-282  DOI:10.1016/s0002-8703(97)70220-5  PMID:9060794
  • Eisenberg, M. J., Califf, R. M., Cohen, E. A., Adelman, A. G., Mark, D. B., Topol, E. J. Use of evidence-based medical therapy in patients undergoing percutaneous coronary revascularization in the united states, europe, and canada American Journal of Cardiology  1997 79:867-872  PMID:9104896
  • Anderson, R. D., Ohman, E. M., Holmes, D. R., Col, J., Stebbins, A. L., Bates, E. R., Stomel, R. J., Granger, C. B., Topol, E. J., Califf, R. M. Use of intraaortic balloon counterpulsation in patients presenting with cardiogenic shock: Observations from the gusto-i study Journal of the American College of Cardiology  1997 30:708-715  DOI:10.1016/s0735-1097(97)00227-1  PMID:9283530
  • Brener, S. J., Leya, F. S., AppersonHansen, C., Cowley, M. J., Califf, R. M., Topol, E. J. A comparison of debulking versus dilatation of bifurcation coronary arterial narrowings (from the caveat i trial) American Journal of Cardiology  1996 78:1039-1041  DOI:10.1016/s0002-9149(96)00531-0  PMID:8916485
  • Topol, E. J., Califf, R., Granger, C., VandeWerf, F., Aylward, P., Simes, J., Col, J., Armstrong, P., Vahanian, A., Neuhaus, K., Rutsch, W., Ardissino, D., et al. A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes New England Journal of Medicine  1996 335:775-782  DOI:10.1056/NEJM199609123351103  PMID:8778585
  • Gent, M., Beaumont, D., Blanchard, J., Bousser, M. G., Coffman, J., Easton, J. D., Hampton, J. R., Harker, L. A., Janzon, L., Kusmierek, J. J. E., Panak, E., Roberts, R. S., et al. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (caprie) Lancet  1996 348:1329-1339  PMID:8918275
  • Mak, K. H., Eisenberg, M. J., Plante, S., Strauss, B. H., Arheart, K. L., Topol, E. J. Absence of increased in-hospital complications with reused balloon catheters American Journal of Cardiology  1996 78:717-719  DOI:10.1016/s0002-9149(96)00443-2  PMID:8831419
  • Granger, C. B., Hirsh, J., Califf, R. M., Col, J., White, H. D., Betriu, A., Woodlief, L. H., Lee, K. L., Bovill, E. G., Simes, J., Topol, E. J. Activated partial thromboplastin time and outcome after thrombolytic therapy for acute myocardial infarction: Results for the gusto-i trial Circulation  1996 93:870-878  PMID:8598077
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  • Ellis, S. G., Omoigui, N., Bittl, J. A., Lincoff, M., Wolfe, M. W., Howell, G., Topol, E. J. Analysis and comparison of operator-specific outcomes in interventional cardiology - from a multicenter database of 4860 quality-controlled procedures Circulation  1996 93:431-439  PMID:8565159
  • Woodfield, S. L., Lundergan, C. F., Reiner, J. S., Greenhouse, S. W., Thompson, M. A., Rohrbeck, S. C., Deychak, Y., Simoons, M. L., Califf, R. M., Topol, E. J., Ross, A. M. Angiographic findings and outcome in diabetic patients treated with thrombolytic therapy for acute myocardial infarction: The gusto-i experience Journal of the American College of Cardiology  1996 28:1661-1669  PMID:8962549
  • Almony, G. T., Lefkovits, J., Topol, E. J. Antiplatelet and anticoagulant use after myocardial infarction Clinical Cardiology  1996 19:357-365  PMID:8723593
  • Ohman, E. M., Armstrong, P. W., Christenson, R. H., Granger, C. B., Katus, H. A., Hamm, C. W., Ohanesian, M. A., Wagner, G. S., Kleiman, N. S., Harrell, F. E., Califf, R. M., Topol, E. J. Cardiac troponin t levels for risk stratification in acute myocardial ischemia New England Journal of Medicine  1996 335:1333-1341  DOI:10.1056/nejm199610313351801  PMID:8857016
  • Aguirre, F. V., Topol, E. J., Anderson, K. M., Kleiman, N. S., Weisman, H. E., FitzPatrick, S. E., Califf, R. M. Clinical benefit within patient subgroups receiving c7e3 fab (abciximab) during percutaneous coronary revascularization: Subgroup analysis from the epic trial Journal of Invasive Cardiology  1996 8:B21-B29
  • Challapalli, R., Lefkovits, J., Topol, E. J. Clinical trials of recombinant hirudin in acute coronary syndromes Coronary Artery Disease  1996 7:429-437  DOI:10.1097/00019501-199606000-00005  PMID:8889358
  • Rashid, J., Eisenberg, M. J., Topol, E. J. Cocaine-induced aortic dissection American Heart Journal  1996 132:1301-1304  DOI:10.1016/s0002-8703(96)90486-x  PMID:8969594
  • Weaver, W. D., White, H. D., Wilcox, R. G., Aylward, P. E., Morris, D., Guerci, A., Ohman, M., Barbash, G. I., Betriu, A., Sadowski, Z., Topol, E. J., Califf, R. M. Comparisons of characteristics and outcomes among women and men with acute myocardial infarction treated with thrombolytic therapy JAMA-Journal of the American Medical Association  1996 275:777-782  DOI:10.1001/jama.275.10.777  PMID:8598594
  • Pepine, C. J., Holmes, D. R., Block, P. C., Brinker, J. A., Mark, D. B., Mullins, C. E., Nissen, S. E., Topol, E. J., Williams, D. O., Goldberg, S., Hirshfeld, J. W., Serruys, P. W. Coronary artery stents Journal of the American College of Cardiology  1996 28:782-794  PMID:8772772
  • Mak, K. H., Eisenberg, M. J., Eccleston, D. S., Brown, K. J., Ellis, S. G., Topol, E. J. Cost-efficacy modeling of catheter reuse for percutaneous transluminal coronary angioplasty Journal of the American College of Cardiology  1996 28:106-111  DOI:10.1016/0735-1097(96)00097-6  PMID:8752801
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  • Rao, A. K., Sun, L., Chesebro, J. H., Fuster, V., Harrington, R. A., Schwartz, D., Gallo, P., Matos, D., Topol, E. J. Distinct effects of recombinant desulfatohirudin (revasc) and heparin on plasma levels of fibrinopeptide a and prothrombin fragment f1.2 in unstable angina - a multicenter trial Circulation  1996 94:2389-2395  PMID:8921778
  • Newby, L. K., Califf, R. M., Guerci, A., Weaver, W. D., Col, J., Horgan, J. H., Mark, D. B., Stebbins, A., VandeWerf, F., Gore, J. M., Topol, E. J. Early discharge in the thrombolytic era: An analysis of criteria for uncomplicated infarction from the global utilization of streptokinase and t-pa for occluded coronary arteries (gusto) trial Journal of the American College of Cardiology  1996 27:625-632  PMID:8606274
  • Topol, E. J. Early myocardial reperfusion: An assessment of current strategies in acute myocardial infarction European Heart Journal  1996 17:42-48  PMID:11824003
  • Mark, D. B., Talley, J. D., Topol, E. J., Bowman, L., Lam, L. C., Anderson, K. M., Jollis, J. G., Cleman, M. W., Lee, K. L., Aversano, T., Untereker, W. J., DavidsonRay, L., et al. Economic assessment of platelet glycoprotein iib/iiia inhibition for prevention of ischemic complications of high-risk coronary angioplasty Circulation  1996 94:629-635  PMID:8772681
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  • Schulman, S. P., GoldschmidtClermont, P. J., Topol, E. J., Califf, R. M., Navetta, F. I., Willerson, J. T., Chandra, N. C., Guerci, A. D., Ferguson, J. J., Harrington, R. A., Lincoff, A. M., Yakubov, S. J., et al. Effects of integrelin, a platelet glycoprotein iib/iiia receptor antagonist, in unstable angina - a randomized multicenter trial Circulation  1996 94:2083-2089  PMID:8901655
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  • Sgarbossa, E. B., Pinski, S. L., Barbagelata, A., Underwood, D. A., Gates, K. B., Topol, E. J., Califf, R. M., Wagner, G. S. Electrocardiographic diagnosis of evolving acute myocardial infarction in the presence of left bundle-branch block New England Journal of Medicine  1996 334:481-487  DOI:10.1056/nejm199602223340801  PMID:8559200
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  • Redlitz, A., Nicolini, F. A., Malycky, J. L., Topol, E. J., Plow, E. F. Inducible carboxypeptidase activity - a role in clot lysis in vivo Circulation  1996 93:1328-1330  PMID:8641019
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  • Guzman, L. A., Labhasetwar, V., Song, C. X., Jang, Y. S., Lincoff, A. M., Levy, R., Topol, E. J. Local intraluminal infusion of biodegradable polymeric nanoparticles - a novel approach for prolonged drug delivery after balloon angioplasty Circulation  1996 94:1441-1448  PMID:8823004
  • vanderGiessen, W. J., Lincoff, A. M., Schwartz, R. S., vanBeusekom, H. M. M., Serruys, P. W., Holmes, D. R., Ellis, S. G., Topol, E. J. Marked inflammatory sequelae to implantation of biodegradable and nonbiodegradable polymers in porcine coronary arteries Circulation  1996 94:1690-1697  PMID:8840862
  • Califf, R. M., White, H. D., VandeWerf, E. V., Sadowski, Z., Armstrong, P. W., Vahanian, A., Simoons, M. L., Simes, R. J., Lee, K. L., Topol, E. J. One-year results from the global utilization of streptokinase and tpa for occluded coronary arteries (gusto-i) trial Circulation  1996 94:1233-1238  PMID:8822974
  • Omoigui, N. A., Miller, D. P., Brown, K. J., Annan, K., Cosgrove, D., Lytle, B., Loop, F., Topol, E. J. Outmigration for coronary bypass surgery in an era of public dissemination of clinical outcomes Circulation  1996 93:27-33  PMID:8616936
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  • Eisenberg, M. J., Topol, E. J. Prehospital administration of aspirin in patients with unstable angina and acute myocardial infarction Archives of Internal Medicine  1996 156:1506-1510  DOI:10.1001/archinte.156.14.1506  PMID:8687258
  • Peterson, E. D., Hathaway, W. R., Zabel, K. M., Pieper, K. S., Granger, C. B., Wagner, G. S., Topol, E. J., Bates, E. R., Simoons, M. L., Califf, R. M. Prognostic significance of precordial st segment depression during inferior myocardial infarction in the thrombolytic era: Results in 16,521 patients Journal of the American College of Cardiology  1996 28:305-312  DOI:10.1016/0735-1097(96)00133-7  PMID:8800102
  • Horrigan, M. C. G., MacIsaac, A. I., Nicolini, F. A., Vince, D. G., Lee, P., Ellis, S. G., Topol, E. J. Reduction in myocardial infarct size by basic fibroblast growth factor after temporary coronary occlusion in a canine model Circulation  1996 94:1927-1933  PMID:8873670
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  • Aylward, P. E., Wilcox, R. G., Horgan, J. H., White, H. D., Granger, C. B., Califf, R. M., Topol, E. J. Relation of increased arterial blood pressure to mortality and stroke in the context of contemporary thrombolytic therapy for acute myocardial infarction - a randomized trial Annals of Internal Medicine  1996 125:891-900  PMID:8967669
  • GottsaunerWolf, M., Moliterno, D. J., Lincoff, A. M., Topol, E. J. Restenosis - an open file Clinical Cardiology  1996 19:347-356  PMID:8723592
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  • Nicolini, F. A., Lee, P., Malycky, J. L., Lefkovits, J., KottkeMarchant, K., Plow, E. F., Topol, E. J. Selective inhibition of factor xa during thrombolytic therapy markedly improves coronary artery patency in a canine model of coronary thrombosis Blood Coagulation & Fibrinolysis  1996 7:39-48  DOI:10.1097/00001721-199601000-00005  PMID:8845461
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  • Muller, D. W. M., Gordon, D., Topol, E. J., Levy, R. J., Golomb, G. Sustained-release local hirulog therapy decreases early thrombosis but not neointimal thickening after arterial stenting American Heart Journal  1996 131:211-218  DOI:10.1016/s0002-8703(96)90343-9  PMID:8579010
  • Lefkovits, J., Topol, E. J. The clinical role of platelet glycoprotein IIb/IIIa receptor inhibitors in ischemic heart disease Cleveland Clinic Journal of Medicine  1996 63:181-189  PMID:8665658
  • Barsness, G. W., Ohman, E. M., Califf, R. M., Kereiakes, D. J., George, B. S., Topol, E. J. The thrombolysis and angioplasty in myocardial infarction (tami) trials: A decade of reperfusion strategies Journal of Interventional Cardiology  1996 9:89-115  DOI:10.1111/j.1540-8183.1996.tb00604.x
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  • Pichard, A., Ivanhoe, R., Satler, L., Masden, R., Chapekis, A., Lee, K. L., Reen, B., Levine, G., Abbottsmith, C., Gottlieb, R. S., Stillabower, M., Chambers, J., et al. A multicenter, randomized trial of coronary angioplasty versus directional atherectomy for patients with saphenous vein bypass graft lesions Circulation  1995 91:1966-1974  PMID:7895354
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  • Silver, M. J., Sutton, J. M., Hook, S., Lee, P., Malycky, J. L., Phillips, M. L., Ellis, S. G., Topol, E. J., Nicolini, F. A. Adjunctive selectin blockade successfully reduces infarct size beyond thrombolysis in the electrolytic canine coronary-artery model Circulation  1995 92:492-499  PMID:7543381
  • Califf, R. M., Lincoff, A. M., Tcheng, J. E., Topol, E. J. An overview of the results of the EPIC trial European Heart Journal  1995 16:43-49  PMID:8869018
  • Gersh, B. J., Topol, E. J. Angioplasty or thrombolysis in acute myocardial-infarction - dilate or dissolve Cleveland Clinic Journal of Medicine  1995 62:15-19  PMID:7859398
  • Aguirre, F. V., Topol, E. J., Ferguson, J. J., Anderson, K., Blankenship, J. C., Heuser, R. R., Sigmon, K., Taylor, M., Gottlieb, R., Hanovich, G., Rosenberg, M., Donohue, T. J., et al. Bleeding complications with the chimeric antibody to platelet glycoprotein iib/iiia integrin in patients undergoing percutaneous coronary intervention Circulation  1995 91:2882-2890  PMID:7796496
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  • Holmes, D. R., Bates, E. R., Kleiman, N. S., Sadowski, Z., Horgan, J. H. S., Morris, D. C., Califf, R. M., Berger, P. B., Topol, E. J. Contemporary reperfusion therapy for cardiogenic-shock - the gusto-i trial experience Journal of the American College of Cardiology  1995 26:668-674  DOI:10.1016/0735-1097(95)00215-p  PMID:7642857
  • Williams, D. O., Baim, D. S., Bates, E., Bonan, R., Bost, J. E., Cowley, M., Faxon, D. P., Feit, F., Jones, R., Kellett, M. A., Kelsey, S. F., Sopko, G., et al. Coronary anatomic and procedural characteristics of patients randomized to coronary angioplasty in the bypass angioplasty revascularization investigation (bari) American Journal of Cardiology  1995 75:C27-C33  DOI:10.1016/s0002-9149(99)80392-0
  • Mark, D. B., Hlatky, M. A., Califf, R. M., Naylor, C. D., Lee, K. L., Armstrong, P. W., Barbash, G., White, H., Simoons, M. L., Nelson, C. L., Clappchanning, N., Knight, J. D., et al. Cost-effectiveness of thrombolytic therapy with tissue-plasminogen activator as compared with streptokinase for acute myocardial-infarction New England Journal of Medicine  1995 332:1418-1424  DOI:10.1056/nejm199505253322106  PMID:7723799
  • Christenson, R. H., Ohman, E. M., Topol, E. J., Ohanesian, M. A., Sigmon, K. N., Duh, S. H., Kereiakes, D., Worley, S. J., George, B. S., Pizzo, C. K., Wall, T. C., Califf, R. M. Creatine-kinase mm and mb isoforms in patients receiving thrombolytic therapy and acute angiography Clinical Chemistry  1995 41:844-852  PMID:7768002
  • Boehrer, J. D., Ellis, S. G., Pieper, K., Holmes, D. R., Keeler, G. P., Debowey, D., Chapekis, A. T., Leya, F., Mooney, M. R., Gottlieb, R. S., Serruys, P. W., Califf, R. M., et al. Directional atherectomy versus balloon angioplasty for coronary ostial and nonostial left anterior descending coronary-artery lesions - results from a randomized multicenter trial Journal of the American College of Cardiology  1995 25:1380-1386  DOI:10.1016/0735-1097(95)00008-r  PMID:7722137
  • Grines, C. L., Topol, E. J., Oneill, W. W., George, B. S., Kereiakes, D., Phillips, H. R., Leimberger, J. D., Woodlief, L. H., Califf, R. M. Effect of cigarette-smoking on outcome after thrombolytic therapy for myocardial-infarction Circulation  1995 91:298-303  PMID:7805231
  • Moliterno, D. J., Califf, R. M., Aguirre, F. V., Anderson, K., Sigmon, K. N., Weisman, H. F., Topol, E. J. Effect of platelet glycoprotein iib/iiia integrin blockade on activated clotting time during percutaneous transluminal coronary angioplasty or directional atherectomy (the epic trial) American Journal of Cardiology  1995 75:559-562  DOI:10.1016/s0002-9149(99)80616-x  PMID:7887377
  • Villa, A. E., Guzman, L. A., Poptic, E. J., Labhasetwar, V., Dsouza, S., Farrell, C. L., Plow, E. F., Levy, R. J., Dicorleto, P. E., Topol, E. J. Effects of antisense c-myb oligonucleotides on vascular smooth-muscle cell-proliferation and response to vessel wall injury Circulation Research  1995 76:505-513  PMID:7895327
  • Barbash, G. I., Reiner, J., White, H. D., Wilcox, R. G., Armstrong, P. W., Sadowski, Z., Morris, D., Aylward, P., Woodlief, L. H., Topol, E. J., Califf, R. M., Ross, A. M. Evaluation of paradoxic beneficial-effects of smoking in patients receiving thrombolytic therapy for acute myocardial-infarction - mechanism of the smokers paradox from the gusto-i trial, with angiographic insights Journal of the American College of Cardiology  1995 26:1222-1229  DOI:10.1016/0735-1097(95)00299-5  PMID:7594035
  • Barbagelata, A., Granger, C. B., Topol, E. J., Worley, S. J., Kereiakes, D. J., George, B. S., Ohman, E. M., Leimberger, J. D., Mark, D. B., Califf, R. M. Frequency, significance, and cost of recurrent ischemia after thrombolytic therapy for acute myocardial-infarction American Journal of Cardiology  1995 76:1007-1013  DOI:10.1016/s0002-9149(99)80285-9  PMID:7484852
  • Robinson, K., Mayer, E. L., Miller, D. P., Green, R., Vanlente, F., Gupta, A., Kottkemarchant, K., Savon, S. R., Selhub, J., Nissen, S. E., Kutner, M., Topol, E. J. Hyperhomocysteinemia and low pyridoxal-phosphate - common and independent reversible risk-factors for coronary-artery disease Circulation  1995 92:2825-2830  PMID:7586248
  • Harrington, R. A., Kleiman, N. S., Kottkemarchant, K., Lincoff, A. M., Tcheng, J. E., Sigmon, K. N., Joseph, D., Rios, G., Trainor, K., Rose, D., Greenberg, C. S., Kitt, M. M., et al. Immediate and reversible platelet inhibition after intravenous administration of a peptide glycoprotein iib/iiia inhibitor during percutaneous coronary intervention American Journal of Cardiology  1995 76:1222-1227  DOI:10.1016/s0002-9149(99)80345-2  PMID:7503000
  • Ellis, S. G., Miller, D. P., Brown, K. J., Omoigui, N., Howell, G. L., Kutner, M., Topol, E. J. In-hospital cost of percutaneous coronary revascularization - critical determinants and implications Circulation  1995 92:741-747  PMID:7641352
  • Jang, Y. S., Guzman, L. A., Lincoff, A. M., Gottsaunerwolf, M., Forudi, F., Hart, C. E., Courtman, D. W., Ezban, M., Ellis, S. G., Topol, E. J. Influence of blockade at specific levels of the coagulation cascade on restenosis in a rabbit atherosclerotic femoral-artery injury model Circulation  1995 92:3041-3050  PMID:7586275
  • Eccleston, D., Topol, E. J. Inhibitors of platelet glycoprotein IIb/IIIa as augmenters of thrombolysis Coronary Artery Disease  1995 6:947-955  PMID:8723017
  • Holmes, D. R., Califf, R. M., Topol, E. J. Lessons we have learned from the gusto trial Journal of the American College of Cardiology  1995 25:S10-S17  DOI:10.1016/0735-1097(95)90011-x
  • Simes, R. J., Topol, E. J., Holmes, D. R., White, H. D., Rutsch, W. R., Vahanian, A., Simoons, M. L., Morris, D., Betriu, A., Califf, R. M., Ross, A. M. Link between the angiographic substudy and mortality outcomes in a large randomized trial of myocardial reperfusion - importance of early and complete infarct artery reperfusion Circulation  1995 91:1923-1928  PMID:7895348
  • Abdelmeguid, A. E., Whitlow, P. L., Sapp, S. K., Ellis, S. G., Topol, E. J. Long-term outcome of transient, uncomplicated in-laboratory coronary artery closure Circulation  1995 91:2733-2741  PMID:7758178
  • Lefkovits, J., Plow, E. F., Topol, E. J. Mechanisms of disease - platelet glycoprotein IIb/IIIa receptors in cardiovascular medicine New England Journal of Medicine  1995 332:1553-1559  PMID:7739710
  • Smalling, R. W., Bode, C., Kalbfleisch, J., Sen, S., Limbourg, P., Forycki, F., Habib, G., Feldman, R., Hohnloser, S., Seals, A., Califf, R., Guerci, A., et al. More rapid, complete, and stable coronary thrombolysis with bolus administration of reteplase compared with alteplase infusion in acute myocardial infarction Circulation  1995 91:2725-2732  PMID:7758177
  • Tcheng, J. E., Harrington, R. A., Kottkemarchant, K., Kleiman, N. S., Ellis, S. G., Kereiakes, D. J., Mick, M. J., Navetta, F. I., Smith, J. E., Worley, S. J., Miller, J. A., Joseph, D. M., et al. Multicenter, randomized, double-blind, placebo-controlled trial of the platelet integrin glycoprotein iib/iiia blocker integrelin in elective coronary intervention Circulation  1995 91:2151-2157  PMID:7697843
  • Topol, E. J. Novel antithrombotic approaches to coronary-artery disease American Journal of Cardiology  1995 75:B27-B33  DOI:10.1016/0002-9149(95)80007-f
  • Omoigui, N. A., Topol, E. J. Observational versus randomized medical device testing before and after market approval - the atherectomy-versus-angioplasty controversy Controlled Clinical Trials  1995 16:143-149  DOI:10.1016/0197-2456(95)00035-f  PMID:7796597
  • Elliott, J. M., Berdan, L. G., Holmes, D. R., Isner, J. M., King, S. B., Keeler, G. P., Kearney, M., Califf, R. M., Topol, E. J. One-year follow-up in the coronary angioplasty versus excisional atherectomy trial (caveat-i) Circulation  1995 91:2158-2166  PMID:7697844
  • Topol, E. J., Nissen, S. E. Our preoccupation with coronary luminology - the dissociation between clinical and angiographic findings in ischemic-heart-disease Circulation  1995 92:2333-2342  PMID:7554219
  • Abdelmeguid, A. E., Whitlow, P. L., Simpfendorfer, C., Sapp, S. K., Franco, I., Ellis, S. G., Topol, E. J. Percutaneous revascularization of ostial saphenous-vein graft stenoses Journal of the American College of Cardiology  1995 26:955-960  DOI:10.1016/0735-1097(95)00266-x  PMID:7560623
  • Omoigui, N. A., Califf, R. M., Pieper, K., Keeler, G., Ohanesian, M. A., Berdan, L. G., Mark, D. B., Talley, J. D., Topol, E. J. Peripheral vascular complications in the coronary angioplasty versus excisional atherectomy trial (caveat-i) Journal of the American College of Cardiology  1995 26:922-930  DOI:10.1016/0735-1097(95)00263-4  PMID:7560619
  • Lefkovits, J., Topol, E. J. Platelet glycoprotein iib/iiia receptor inhibitors in ischemic-heart-disease Current Opinion in Cardiology  1995 10:420-426  DOI:10.1097/00001573-199507000-00012  PMID:7549085
  • Lefkovits, J., Holmes, D. R., Califf, R. M., Safian, R. D., Pieper, K., Keeler, G., Topol, E. J. Predictors and sequelae of distal embolization during saphenous-vein graft intervention from the caveat-ii trial Circulation  1995 92:734-740  PMID:7641351
  • Lee, K. L., Woodlief, L. H., Topol, E. J., Weaver, W. D., Betriu, A., Col, J., Simoons, M., Aylward, P., Vandewerf, F., Califf, R. M. Predictors of 30-day mortality in the era of reperfusion for acute myocardial-infarction - results from an international trial of 41 021 patients Circulation  1995 91:1659-1668  PMID:7882472
  • Topol, E. J. Prevention of cardiovascular ischemic complications with new platelet glycoprotein IIb/IIIa inhibitors American Heart Journal  1995 130:666-672  DOI:10.1016/0002-8703(95)90304-6  PMID:7668215
  • Ellis, S. G., Cowley, M. J., Whitlow, P. L., Vandormael, M., Lincoff, A. M., Disciascio, G., Dean, L. S., Topol, E. J. Prospective case-control comparison of percutaneous transluminal coronary revascularization in patients with multivessel disease treated in 1986-1987 versus 1991 - improved in-hospital and 12-month results Journal of the American College of Cardiology  1995 25:1137-1142  DOI:10.1016/0735-1097(94)00541-w  PMID:7897127
  • Moliterno, D. J., Elliott, J. M., Topol, E. J. Randomized trials of myocardial revascularization Current Problems in Cardiology  1995 20:128-190  DOI:10.1016/s0146-2806(06)80025-3
  • Pilote, L., Califf, R. M., Sapp, S., Miller, D. P., Mark, D. B., Weaver, W. D., Gore, J. M., Armstrong, P. W., Ohman, E. M., Topol, E. J. Regional variation across the united-states in the management of acute myocardial-infarction New England Journal of Medicine  1995 333:565-572  DOI:10.1056/nejm199508313330907  PMID:7623907
  • Guzman, L. A., Forudi, F., Villa, A. E., Topol, E. J. Role of leukocytes in neointimal formation after balloon angioplasty in the rabbit atherosclerotic model Coronary Artery Disease  1995 6:693-701  PMID:8747874
  • Lincoff, A. M., Topol, E. J., Califf, R. M., Sigmon, K. N., Lee, K. L., Ohman, E. M., Rosenschein, U., Ellis, S. G. Significance of a coronary-artery with thrombolysis in myocardial-infarction grade-2 flow patency (outcome in the thrombolysis and angioplasty in myocardial-infarction trials) American Journal of Cardiology  1995 75:871-876  DOI:10.1016/s0002-9149(99)80678-x  PMID:7732992
  • Gore, J. M., Granger, C. B., Simoons, M. L., Sloan, M. A., Weaver, D., White, H. D., Barbash, G. I., Vandewerf, F., Aylward, P. E., Topol, E. J., Califf, R. M. Stroke after thrombolysis - mortality and functional outcomes in the gusto-i trial Circulation  1995 92:2811-2818  PMID:7586246
  • Karnash, S. L., Granger, C. B., White, H. D., Woodlief, L. H., Topol, E. J., Califf, R. M. Treating menstruating women with thrombolytic therapy - insights from the global utilization of streptokinase and tissue-plasminogen activator for occluded coronary-arteries (gusto-i) trial Journal of the American College of Cardiology  1995 26:1651-1656  DOI:10.1016/0735-1097(95)00386-x  PMID:7594099
  • Vandewerf, F., Topol, E. J., Lee, K. L., Woodlief, L. H., Granger, C. B., Armstrong, P. W., Barbash, G. I., Hampton, J. R., Guerci, A., Simes, R. J., Ross, A. M., Califf, R. M. Variations in patient-management and outcomes for acute myocardial-infarction in the united-states and other countries - results from the gusto trial JAMA-Journal of the American Medical Association  1995 273:1586-1591  DOI:10.1001/jama.273.20.1586  PMID:7745771
  • Nissen, S. E., Pepine, C. J., Bashore, T. M., Block, P. C., Bonchek, L. I., Brinker, J. A., Carabello, B., Douglas, J. S., Elion, J. L., Hirshfeld, J. W., Holmes, D. R., Johnson, W. L., et al. Cardiac angiography without cine film - erecting a tower-of-babel in the cardiac-catheterization laboratory Journal of the American College of Cardiology  1994 24:834-837  PMID:8077561
  • Jang, Y. S., Lincoff, A. M., Plow, E. F., Topol, E. J. Cell-adhesion molecules in coronary-artery disease Journal of the American College of Cardiology  1994 24:1591-1601  PMID:7963103
  • Harrington, R. A., Sane, D. C., Califf, R. M., Sigmon, K. N., Abbottsmith, C. W., Candela, R. J., Lee, K. L., Topol, E. J. Clinical importance of thrombocytopenia occurring in the hospital phase after administration of thrombolytic therapy for acute myocardial-infarction Journal of the American College of Cardiology  1994 23:891-898  PMID:8106694
  • Nicolini, F. A., Lee, P., Rios, G., Kottkemarchant, K., Topol, E. J. Combination of platelet fibrinogen receptor antagonist and direct thrombin inhibitor at low-doses markedly improves thrombolysis Circulation  1994 89:1802-1809  PMID:8149546
  • Maclsaac, A. I., Ellis, S. G., Muller, D. W., Topol, E. J., Whitlow, P. L. Comparison of 3 coronary stents - clinical and angiographic outcome after elective placement in 134 consecutive patients Catheterization and Cardiovascular Diagnosis  1994 33:199-204  DOI:10.1002/ccd.1810330302  PMID:7874711
  • Rosenschein, U., Ellis, S. G., Haudenschild, C. C., Yakubov, S. J., Muller, D. W. M., Dick, R. J., Topol, E. J. Comparison of histopathologic coronary lesions obtained from directional atherectomy in stable angina versus acute coronary syndromes American Journal of Cardiology  1994 73:508-510  DOI:10.1016/0002-9149(94)90683-1  PMID:8141093
  • Paranandi, S. N., Topol, E. J. Contemporary clinical-trials of restenosis Journal of Invasive Cardiology  1994 6:109-124  PMID:10147167
  • Braunwald, E., Jones, R. H., Mark, D. B., Brown, J., Brown, L., Cheitlin, M. D., Concannon, C. A., Cowan, M., Edwards, C., Fuster, V., Goldman, L., Green, L. A., et al. Diagnosing and managing unstable angina Circulation  1994 90:613-622  PMID:8026048
  • Holmes, D. R., Topol, E. J. Dilate or debulk Cleveland Clinic Journal of Medicine  1994 61:124-126  PMID:8194176
  • Lefkovits, J., Topol, E. J. Direct thrombin inhibitors in cardiovascular medicine Circulation  1994 90:1522-1536  PMID:8087958
  • Reiner, J. S., Lundergan, C. F., Vandenbrand, M., Boland, J., Thompson, M. A., Machecourt, J., Py, A., Pilcher, G. S., Fink, C. A., Burton, J. R., Simoons, M. L., Califf, R. M., et al. Early angiography cannot predict postthrombolytic coronary reocclusion - observations from the gusto angiographic study Journal of the American College of Cardiology  1994 24:1439-1444  PMID:7930273
  • Boehrer, J. D., Kereiakes, D. J., Navetta, F. I., Califf, R. M., Topol, E. J. Effects of profound platelet inhibition with c7e3 before coronary angioplasty on complications of coronary-bypass survey American Journal of Cardiology  1994 74:1166-1170  DOI:10.1016/0002-9149(94)90474-x  PMID:7977081
  • Steinberg, J. S., Hochman, J. S., Morgan, C. D., Dorian, P., Naylor, C. D., Theroux, P., Topol, E. J., Armstrong, P. W. Effects of thrombolytic therapy administered 6 to 24 hours after myocardial-infarction on the signal-averaged ecg - results of a multicenter randomized trial Circulation  1994 90:746-752  PMID:8044943
  • Lefkovits, J., Topol, E. J. Future-directions in thrombolysis for myocardial-infarction - what are the unanswered questions Coronary Artery Disease  1994 5:306-316  DOI:10.1097/00019501-199404000-00006  PMID:8044342
  • Lee, K. L., Califf, R. M., Simes, J., Vandewerf, F., Topol, E. J. Holding gusto up to the light Annals of Internal Medicine  1994 120:876-881  PMID:8154647
  • Kawai, C., Simoons, M. L., Baigent, C., Lenert, L. A., Collins, R., Lopezsendon, J., Parish, S., Knatterud, G., Visani, L., Halls, H., Nicklas, J., Mead, G., et al. Indications for fibrinolytic therapy in suspected acute myocardial infarction - collaborative overview of early mortality and major morbidity results from all randomized trials of more than 1000 patients Lancet  1994 343:311-322  PMID:7905143
  • Wall, T. C., Califf, R. M., Blankenship, J., Talley, J. D., Tannenbaum, M., Schwaiger, M., Gacioch, G., Cohen, M. D., Sanz, M., Leimberger, J. D., Topol, E. J. Intravenous fluosol in the treatment of acute myocardial-infarction - results of the thrombolysis and angioplasty in myocardial-infarction-9 trial Circulation  1994 90:114-120  PMID:8025985
  • Defranco, A. C., Topol, E. J. Invasive strategies for acute myocardial-infarction in the elderly Cardiology in the Elderly  1994 2:274-289
  • Villa, A. E., Guzman, L. A., Chen, W. L., Golomb, G., Levy, R. J., Topol, E. J. Local-delivery of dexamethasone for prevention of neointimal proliferation in a rat model of balloon angioplasty Journal of Clinical Investigation  1994 93:1243-1249  DOI:10.1172/jci117078  PMID:8132764
  • Lincoff, A. M., Topol, E. J., Ellis, S. G. Local-drug delivery for the prevention of restenosis - fact, fancy, and future Circulation  1994 90:2070-2084  PMID:7923695
  • Savage, M. P., Fischman, D. L., Schatz, R. A., Teirstein, P. S., Leon, M. B., Baim, D., Ellis, S. G., Topol, E. J., Hirshfeld, J. W., Cleman, M. W., Buchbinder, M., Bailey, S., et al. Long-term angiographic and clinical outcome after implantation of a balloon-expandable stent in the native coronary circulation Journal of the American College of Cardiology  1994 24:1207-1212  PMID:7930240
  • Faxon, D. P., Spiro, T. E., Minor, S., Cote, G., Douglas, J., Gottlieb, R., Califf, R., Dorosti, K., Topol, E., Gordon, J. B., Ohmen, M., Raizner, A., et al. Low-molecular-weight heparin in prevention of restenosis after angioplasty - results of enoxaparin restenosis (era) trial Circulation  1994 90:908-914  PMID:8044962
  • Sutton, J. M., Ellis, S. G., Roubin, G. S., Pinkerton, C. A., King, S. B., Raizner, A. E., Holmes, D. R., Kereiakes, D. J., Topol, E. J. Major clinical events after coronary stenting - the multicenter registry of acute and elective gianturco-roubin stent placement Circulation  1994 89:1126-1137  PMID:8124799
  • Hicks, R. J., Melon, P., Kalff, V., Wolfe, E., Dick, R. J., Popma, J. J., Topol, E., Schwaiger, M. Metabolic imaging by positron emission tomography early after myocardial-infarction as a predictor of recovery of myocardial-function after reperfusion Journal of Nuclear Cardiology  1994 1:124-137  DOI:10.1007/bf02984084  PMID:9420679
  • Kleiman, N. S., White, H. D., Ohman, E. M., Ross, A. M., Woodlief, L. H., Califf, R. M., Holmes, D. R., Bates, E., Pfisterer, M., Vahanian, A., Topol, E. J. Mortality within 24 hours of thrombolysis for myocardial-infarction - the importance of early reperfusion Circulation  1994 90:2658-2665  PMID:7994805
  • Tcheng, J. E., Ellis, S. G., George, B. S., Kereiakes, D. J., Kleiman, N. S., Talley, J. D., Wang, A. L., Weisman, H. F., Califf, R. M., Topol, E. J. Pharmacodynamics of chimeric glycoprotein iib/iiia integrin antiplatelet antibody fab 7e3 in high-risk coronary angioplasty Circulation  1994 90:1757-1764  PMID:7923659
  • Brown, D. L., Macisaac, A. I., Topol, E. J. Pulmonary hemorrhage after intracoronary stent placement Journal of the American College of Cardiology  1994 24:91-94  PMID:8006287
  • Ellis, S. G., Dasilva, E. R., Heyndrickx, G., Talley, J. D., Cernigliaro, C., Steg, G., Spaulding, C., Nobuyoshi, M., Erbel, R., Vassanelli, C., Topol, E. J. Randomized comparison of rescue angioplasty with conservative management of patients with early failure of thrombolysis for acute anterior myocardial-infarction Circulation  1994 90:2280-2284  PMID:7955184
  • Ellis, S. G., Lincoff, A. M., George, B. S., Kereiakes, D. J., Ohman, E. M., Krucoff, M. W., Califf, R. M., Topol, E. J. Randomized evaluation of coronary angioplasty for early timi-2 flow after thrombolytic therapy for the treatment of acute myocardial-infarction - a new look at an old study Coronary Artery Disease  1994 5:611-615  DOI:10.1097/00019501-199407000-00009  PMID:7952423
  • Topol, E. J., Califf, R. M., Weisman, H. F., Ellis, S. G., Tcheng, J. E., Worley, S., Ivanhoe, R., George, B. S., Fintel, D., Weston, M., Sigmon, K., Anderson, K. M., et al. Randomized trial of coronary intervention with antibody against platelet iib/iiia integrin for reduction of clinical restenosis - results at 6 months Lancet  1994 343:881-886  DOI:10.1016/s0140-6736(94)90007-8  PMID:7908357
  • Topol, E., Califf, R., Vandewerf, F., Ardissino, D., Armstrong, P., Aylward, P., Barbash, G., Bates, E., Beatt, K., Betriu, A., Chesebro, J., Col, J., et al. Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes Circulation  1994 90:1631-1637  PMID:7923645
  • Vandewerf, F., Santopinto, J., Cordero, F. A., Fainstein, D., Corinaldesi, A., Zavatti, D., Luppi, O., Iparraguirre, H. P., Hirschson, A., Piombo, A., Lapuente, A., Kritzer, J., et al. Randomized trial of ridogrel, a combined thromboxane a(2) synthase inhibitor and thromboxane a(2)/prostaglandin endoperoxide receptor antagonist, versus aspirin as adjunct to thrombolysis in patients with acute myocardial-infarction - the ridogrel versus aspirin patency trial (rapt) Circulation  1994 89:588-595  PMID:8313547
  • Holmes, D. R., Topol, E. J., Adelman, A. G., Cohen, E. A., Califf, R. M. Randomized trials of directional coronary atherectomy - implications for clinical-practice and future investigation Journal of the American College of Cardiology  1994 24:431-439  PMID:8034880
  • Topol, E. J., Fuster, V., Harrington, R. A., Califf, R. M., Kleiman, N. S., Kereiakes, D. J., Cohen, M., Chapekis, A., Gold, H. K., Tannenbaum, M. A., Rao, A. K., Debowey, D., et al. Recombinant hirudin for unstable angina-pectoris - a multicenter, randomized angiographic trial Circulation  1994 89:1557-1566  PMID:8149521
  • Flaherty, J. T., Pitt, B., Gruber, J. W., Heuser, R. R., Rothbaum, D. A., Burwell, L. R., George, B. S., Kereiakes, D. J., Deitchman, D., Gustafson, N., Brinker, J. A., Becker, L. C., et al. Recombinant human superoxide-dismutase (h-sod) fails to improve recovery of ventricular-function in patients undergoing coronary angioplasty far acute myocardial-infarction Circulation  1994 89:1982-1991  PMID:8181121
  • Ellis, S. G., Popma, J. J., Buchbinder, M., Franco, I., Leon, M. B., Kent, K. M., Pichard, A. D., Satler, L. F., Topol, E. J., Whitlow, P. L. Relation of clinical presentation, stenosis morphology, and operator technique to the procedural results of rotational atherectomy and rotational atherectomy-facilitated angioplasty Circulation  1994 89:882-892  PMID:8313578
  • Topol, E. J., Califf, R. M. Scorecard cardiovascular medicine - its impact and future-directions Annals of Internal Medicine  1994 120:65-70  PMID:8250458
  • Sgarbossa, E. B., Topol, E. J. Semantic ambiguity, the non-nosology and myocardial-infarction Journal of Clinical Epidemiology  1994 47:441-446  DOI:10.1016/0895-4356(94)90165-1  PMID:7730869
  • Califf, R. M., Shadoff, N., Valett, N., Bates, E., Galeana, A., Knopf, W., Shaftel, J., Bender, M. J., Aversano, T., Raqueno, J., Gurbel, P., Cowfer, J., et al. Use of a monoclonal-antibody directed against the platelet glycoprotein iib/iiia receptor in high-risk coronary angioplasty New England Journal of Medicine  1994 330:956-961  PMID:8121459
  • Mark, D. B., Naylor, C. D., Hlatky, M. A., Califf, R. M., Topol, E. J., Granger, C. B., Knight, J. D., Nelson, C. L., Lee, K. L., Clappchanning, N. E., Sutherland, W., Pilote, L., et al. Use of medical resources and quality-of-life after acute myocardial-infarction in canada and the united-states New England Journal of Medicine  1994 331:1130-1135  DOI:10.1056/nejm199410273311706  PMID:7935638
  • Topol, E. J., Leya, F., Pinkerton, C. A., Whitlow, P. L., Hofling, B., Simonton, C. A., Masden, R. R., Serruys, P. W., Leon, M. B., Williams, D. O., King, S. B., Mark, D. B., et al. A comparison of directional atherectomy with coronary angioplasty in patients with coronary-artery disease New England Journal of Medicine  1993 329:221-227  DOI:10.1056/nejm199307223290401  PMID:8316266
  • Ohman, E. M., Topol, E. J., Califf, R. M., Bates, E. R., Ellis, S. G., Kereiakes, D. J., George, B. S., Samaha, J. K., Kline, E., Sigmon, K. N., Stack, R. S. An analysis of the cause of early mortality after administration of thrombolytic therapy Coronary Artery Disease  1993 4:957-964  DOI:10.1097/00019501-199311000-00002  PMID:8173712
  • Topol, E., Califf, R., Vandewerf, F., Armstrong, P. W., Aylward, P., Barbash, G., Bates, E., Betriu, A., Boissel, J. P., Chesebro, J., Col, J., Debono, D., et al. An international randomized trial comparing 4 thrombolytic strategies for acute myocardial-infarction New England Journal of Medicine  1993 329:673-682  PMID:8204123
  • Topol, E. J., Ellis, S. G., Cosgrove, D. M., Bates, E. R., Muller, D. W. M., Schork, N. J., Schork, M. A., Loop, F. D. Analysis of coronary angioplasty practice in the united-states with an insurance-claims data-base Circulation  1993 87:1489-1497  PMID:8141866
  • Lee, K. S., Topol, E. J., Stewart, W. J. Atypical presentation of papillary fibroelastoma mimicking multiple vegetations in suspected subacute bacterial-endocarditis American Heart Journal  1993 125:1443-1445  DOI:10.1016/0002-8703(93)91025-a  PMID:8480605
  • Defeyter, Pimj, Vansuylen, R. J., Dejaegere, P. P. T., Topol, E. J., Serruys, P. W. Balloon angioplasty for the treatment of lesions in saphenous-vein bypass grafts Journal of the American College of Cardiology  1993 21:1539-1549  PMID:8496517
  • Topol, E. J. Breaking the thrombolytic gridlock - insights from the gusto trial Cleveland Clinic Journal of Medicine  1993 60:445-447  PMID:8287504
  • Topol, E. J., Plow, E. F. Clinical-trials of platelet receptor inhibitors Thrombosis and Haemostasis  1993 70:94-98  PMID:8236122
  • Casale, P. N., Whitlow, P. L., Franco, I., Grigera, F., Pashkow, F. J., Topol, E. J. Comparison of major complication rates with new atherectomy devices for percutaneous coronary intervention in women versus men American Journal of Cardiology  1993 71:1221-1223  DOI:10.1016/0002-9149(93)90650-2  PMID:8480650
  • Krucoff, M. W., Croll, M. A., Pope, J. E., Granger, C. B., Oconnor, C. M., Sigmon, K. N., Wagner, B. L., Ryan, J. A., Lee, K. L., Kereiakes, D. J., Samaha, J. K., Worley, S. J., et al. Continuous 12-lead st-segment recovery analysis in the tami 7 study - performance of a noninvasive method for real-time detection of failed myocardial reperfusion Circulation  1993 88:437-446  PMID:8339407
  • Sane, D. C., Califf, R. M., Sigmon, K. N., Topol, E. J., Stump, D. C. Effect of heparin administration on fibrinogenolysis during thrombolytic therapy with tissue plasminogen activator for acute myocardial infarction Fibrinolysis  1993 7:103-107  DOI:10.1016/0268-9499(93)90030-y
  • Nath, F. C., Muller, D. W. M., Rosenschein, U., Ellis, S. G., Topol, E. J. Heparin monitoring during coronary intervention - activated clotting time versus activated partial thromboplastin time Canadian Journal of Cardiology  1993 9:797-801  PMID:8281479
  • Lincoff, A. M., Topol, E. J. Illusion of reperfusion. Does anyone achieve optimal reperfusion during acute myocardial infarction? Circulation  1993 87:1792-1805  PMID:8353902
  • Lincoff, A. M., Topol, E. J., Chapekis, A. T., George, B. S., Candela, R. J., Muller, D. W. M., Zimmerman, C. A., Ellis, S. G. Intracoronary stenting compared with conventional therapy for abrupt vessel closure complicating coronary angioplasty - a matched case-control study Journal of the American College of Cardiology  1993 21:866-875  PMID:8450155
  • Cowley, M. J., Vandermael, M., Topol, E. J., Whitlow, P. L., Dean, L. S., Bulle, T. M., Ellis, S. G. Is traditionally defined complete revascularization needed for patients with multivessel disease treated by elective coronary angioplasty Journal of the American College of Cardiology  1993 22:1289-1297  PMID:8227782
  • Wall, T. C., Califf, R. M., Ellis, S. G., Sigmon, K., Kereiakes, D., George, B. S., Samaha, J., Sane, D., Stump, D. C., Stack, R. S., Topol, E. J. Lack of impact of early catheterization and fibrin specificity on bleeding complications after thrombolytic therapy Journal of the American College of Cardiology  1993 21:597-603  PMID:8436740
  • Bernardi, M. M., Califf, R. M., Kleiman, N., Ellis, S. G., Topol, E. J. Lack of usefulness of prolonged bleeding times in predicting hemorrhagic events in patients receiving the 7e3 glycoprotein iib/iiia platelet antibody American Journal of Cardiology  1993 72:1121-1125  DOI:10.1016/0002-9149(93)90979-m  PMID:8237799
  • Hampton, J., Wilcox, R., Armstrong, P., Aylward, P., Bett, N., Charbonnier, B., Gulba, D., Heikkila, J., Jensen, G., Lopezbescos, L., Moulopoulos, S., Seabragomes, R., et al. Late assessment of thrombolytic efficacy (late) study with alteplase 6-24 hours after onset of acute myocardial-infarction Lancet  1993 342:759-766  PMID:8103874
  • Chapman, G. D., Ohman, M., Topol, E. J., Candela, R. J., Kereiakes, D. J., Samaha, J., Berrios, E., Pieper, K. S., Young, S. Y., Califf, R. M. Minimizing the risk of inappropriately administering thrombolytic therapy (thrombolysis and angioplasty in myocardial-infarction tami study-group) American Journal of Cardiology  1993 71:783-787  DOI:10.1016/0002-9149(93)90824-v  PMID:8456754
  • George, B. S., Voorhees, W. D., Roubin, G. S., Fearnot, N. E., Pinkerton, C. A., Raizner, A. E., King, S. B., Holmes, D. R., Topol, E. J., Kereiakes, D. J., Hartzler, G. O. Multicenter investigation of coronary stenting to treat acute or threatened closure after percutaneous transluminal coronary angioplasty - clinical and angiographic outcomes Journal of the American College of Cardiology  1993 22:135-143  PMID:8509533
  • Ohman, E. M., Christenson, R. H., Califf, R. M., George, B. S., Samaha, J. K., Kereiakes, D. J., Worley, S. J., Wall, T. C., Berrios, E., Sigmon, K. N., Lee, K., Topol, E. J. Noninvasive detection of reperfusion after thrombolysis based on serum creatine-kinase mb changes and clinical-variables American Heart Journal  1993 126:819-826  DOI:10.1016/0002-8703(93)90694-5  PMID:8213437
  • Granger, C. B., Califf, R. M., Young, S., Candela, R., Samaha, J., Worley, S., Kereiakes, D. J., Topol, E. J. Outcome of patients with diabetes-mellitus and acute myocardial-infarction treated with thrombolytic agents Journal of the American College of Cardiology  1993 21:920-925  PMID:8450161
  • Popma, J. J., Decesare, N. B., Pinkerton, C. A., Kereiakes, D. J., Whitlow, P., King, S. B., Topol, E. J., Holmes, D. R., Leon, M. B., Ellis, S. G. Quantitative-analysis of factors influencing late lumen loss and restenosis after directional coronary atherectomy American Journal of Cardiology  1993 71:552-557  DOI:10.1016/0002-9149(93)90510-j  PMID:8438740
  • Baim, D. S., Hinohara, T., Holmes, D., Topol, E., Pinkerton, C., King, S. B., Whitlow, P., Kereiakes, D., Farley, B., Simpson, J. B. Results of directional coronary atherectomy during multicenter preapproval testing American Journal of Cardiology  1993 72:6E-11E  DOI:10.1016/0002-9149(93)91032-d  PMID:8213572
  • Ellis, S. G., Tcheng, J. E., Navetta, F. I., Muller, D. W. M., Weisman, H. F., Smith, C., Anderson, K. M., Califf, R. M., Topol, E. J. Safety and antiplatelet effect of murine monoclonal-antibody 7e3 fab directed against platelet glycoprotein-iib/iiia in patients undergoing elective coronary angioplasty Coronary Artery Disease  1993 4:167-175  DOI:10.1097/00019501-199302000-00007  PMID:8269208
  • Brown, D. L., Topol, E. J. Stroke complicating percutaneous coronary revascularization American Journal of Cardiology  1993 72:1207-1209  DOI:10.1016/0002-9149(93)90998-r  PMID:8237818
  • Harrison, J. K., Califf, R. M., Woodlief, L. H., Kereiakes, D., George, B. S., Stack, R. S., Ellis, S. G., Lee, K. L., Oneill, W., Topol, E. J. Systolic left-ventricular function after reperfusion therapy for acute myocardial-infarction - an analysis of determinants of improvement Circulation  1993 87:1531-1541  PMID:8491008
  • Ross, A. M., Simoons, M. L., Lundergan, C., Thompson, M., Reiner, J., Deychak, Y., Rohrbeck, S., Coyne, K., Walker, P., Cho, S., Greenhouse, S., Lee, K., et al. The effects of tissue-plasminogen activator, streptokinase, or both on coronary-artery patency, ventricular-function, and survival after acute myocardial-infarction New England Journal of Medicine  1993 329:1615-1622  PMID:8232430
  • Lincoff, A. M., Califf, R. M., Ellis, S. G., Sigmon, K. N., Lee, K. L., Leimberger, J. D., Topol, E. J. Thrombolytic therapy for women with myocardial-infarction - is there a gender-gap Journal of the American College of Cardiology  1993 22:1780-1787  PMID:8245328
  • Nath, F. C., Muller, D. W. M., Ellis, S. G., Rosenschein, U., Chapekis, A., Quain, L., Zimmerman, C., Topol, E. J. Thrombosis of a flexible coil coronary stent - frequency, predictors and clinical outcome Journal of the American College of Cardiology  1993 21:622-627  PMID:8436743
  • Macisaac, A. I., Thomas, J. D., Topol, E. J. Toward the quiescent coronary plaque Journal of the American College of Cardiology  1993 22:1228-1241  PMID:8104965
  • Topol, E. J., Bonan, R., Jewitt, D., Sigwart, U., Kakkar, V. V., Rothman, M., Debono, D., Ferguson, J., Willerson, J. T., Strony, J., Ganz, P., Cohen, M. D., et al. Use of a direct antithrombin, hirulog, in place of heparin during coronary angioplasty Circulation  1993 87:1622-1629  PMID:8491018
  • Kalff, V., Hicks, R. J., Hutchins, G., Topol, E., Schwaiger, M. Use of c-11 acetate and dynamic positron emission tomography to assess regional myocardial oxygen-consumption in patients with acute myocardial-infarction receiving thrombolysis or coronary angioplasty American Journal of Cardiology  1993 71:529-535  DOI:10.1016/0002-9149(93)90507-9  PMID:8438738
  • Topol, E. J. Validation of the early open infarct vessel hypothesis American Journal of Cardiology  1993 72:G40-G45  DOI:10.1016/0002-9149(93)90106-m
  • Topol, E. J., Califf, R. M., Vandormael, M., Grines, C. L., George, B. S., Sanz, M. L., Wall, T., Obrien, M., Schwaiger, M., Aguirre, F. V., Young, S., Popma, J. J., et al. A randomized trial of late reperfusion therapy for acute myocardial infarction Circulation  1992 85:2090-2099  PMID:1591828
  • Popma, J. J., Topol, E. J., Hinohara, T., Pinkerton, C. A., Baim, D. S., King, S. B., Holmes, D. R., Whitlow, P. L., Kereiakes, D. J., Hartzler, G. O., Kent, K. M., Ellis, S. G., et al. Abrupt vessel closure after directional coronary atherectomy Journal of the American College of Cardiology  1992 19:1372-1379  PMID:1593028
  • Lincofe, A. M., Popma, J. J., Ellis, S. G., Hacker, J. A., Topol, E. J. Abrupt vessel closure complicating coronary angioplasty - clinical, angiographic and therapeutic profile Journal of the American College of Cardiology  1992 19:926-935  PMID:1552113
  • Wall, T. C., Califf, R. M., George, B. S., Ellis, S. G., Samaha, J. K., Kereiakes, D. J., Worley, S. J., Sigmon, K., Topol, E. J. Accelerated plasminogen-activator dose regimens for coronary thrombolysis Journal of the American College of Cardiology  1992 19:482-489  PMID:1537998
  • Arnold, A. Z., Topol, E. J. Assessment of reperfusion after thrombolytic therapy for myocardial-infarction American Heart Journal  1992 124:441-447  DOI:10.1016/0002-8703(92)90611-x  PMID:1636587
  • Gacioch, G. M., Ellis, S. G., Lee, L., Bates, E. R., Kirsh, M., Walton, J. A., Topol, E. J. Cardiogenic-shock complicating acute myocardial-infarction - the use of coronary angioplasty and the integration of the new support devices into patient-management Journal of the American College of Cardiology  1992 19:647-653  PMID:1538023
  • Decesare, N. B., Popma, J. J., Holmes, D. R., Dick, R. J., Whitlow, P. L., King, S. B., Pinkerton, C. A., Kereiakes, D. J., Topol, E. J., Haudenschild, C. C., Ellis, S. G. Clinical angiographic and histologic correlates of ectasia after directional coronary atherectomy American Journal of Cardiology  1992 69:314-319  DOI:10.1016/0002-9149(92)90226-o  PMID:1734641
  • Topol, E. J., Armstrong, P., Vandewerf, F., Kleiman, N., Lee, K., Morris, D., Simoons, M., Barbash, G., White, H., Califf, R. M. Confronting the issues of patient safety and investigator conflict-of-interest in an international clinical-trial of myocardial reperfusion Journal of the American College of Cardiology  1992 19:1123-1128  PMID:1564212
  • Grambow, D. W., Topol, E. J. Effect of maximal medical therapy on refractoriness of unstable angina-pectoris American Journal of Cardiology  1992 70:577-581  DOI:10.1016/0002-9149(92)90194-4  PMID:1354937
  • Muller, D. W. M., Ellis, S. G., Topol, E. J. Experimental-models of coronary-artery restenosis Journal of the American College of Cardiology  1992 19:418-432  PMID:1732371
  • Rosenschein, U., Ellis, S. G., Yakubov, S. J., Haudenschild, C. C., Dick, R. J., Topol, E. J. Histopathologic correlates of coronary lesion angiographic morphology - lessons from a directional atherectomy experience Coronary Artery Disease  1992 3:953-961
  • Muller, D. W. M., Topol, E. J., Abrams, G. D., Gallagher, K. P., Ellis, S. G. Intramural methotrexate therapy for the prevention of neointimal thickening after balloon angioplasty Journal of the American College of Cardiology  1992 20:460-466  PMID:1386089
  • Sutton, J. M., Topol, E. J. Left ventricular function assessment and acute myocardial infarction Current Opinion in Cardiology  1992 7:1035-1045  DOI:10.1097/00001573-199212000-00016
  • Popma, J. J., Califf, R. M., Ellis, S. G., George, B. S., Kereiakes, D. J., Samaha, J. K., Worley, S. J., Anderson, J. L., Stump, D., Woodlief, L., Sigmon, K., Wall, T. C., et al. Mechanism of benefit of combination thrombolytic therapy for acute myocardial-infarction - a quantitative angiographic and hematologic study Journal of the American College of Cardiology  1992 20:1305-1312  PMID:1430679
  • Muller, D. W. M., Shamir, K. J., Ellis, S. G., Topol, E. J. Peripheral vascular complications after conventional and complex percutaneous coronary interventional procedures American Journal of Cardiology  1992 69:63-68  DOI:10.1016/0002-9149(92)90677-q  PMID:1729869
  • Ellis, S. G., Mooney, M. R., George, B. S., Dasilva, E. E. R., Talley, J. D., Flanagan, W. H., Topol, E. J., Griffin, B., Samaha, J., Sawicki, E., Mooney, J., Chapekis, A. T., et al. Randomized trial of late elective angioplasty versus conservative management for patients with residual stenoses after thrombolytic treatment of myocardial-infarction Circulation  1992 86:1400-1406  PMID:1423952
  • Ellis, S. G., Savage, M., Fischman, D., Baim, D. S., Leon, M., Goldberg, S., Hirshfeld, J. W., Cleman, M. W., Teirstein, P. S., Walker, C., Bailey, S., Buchbinder, M., et al. Restenosis after placement of palmaz-schatz stents in native coronary-arteries - initial results of a multicenter experience Circulation  1992 86:1836-1844  PMID:1451256
  • Rosenschein, U., Yakubov, S. J., Guberinich, D., Bach, D. S., Sonda, P. L., Abrams, G. D., Topol, E. J. Shock-wave thrombus ablation, a new method for noninvasive mechanical thrombolysis American Journal of Cardiology  1992 70:1358-1361  DOI:10.1016/0002-9149(92)90775-t  PMID:1442591
  • Williamson, B. D., Muller, D. W. M., Topol, E. J. Should older patients with acute myocardial-infarction receive thrombolytic therapy Drugs & Aging  1992 2:461-468  PMID:1493350
  • Schwartz, R. S., Holmes, D. R., Topol, E. J. The restenosis paradigm revisited - an alternative proposal for cellular mechanisms Journal of the American College of Cardiology  1992 20:1284-1293  PMID:1401633
  • Muller, D. W. M., Topol, E. J. Thrombolytic therapy - adjuvant mechanical intervention for acute myocardial-infarction American Journal of Cardiology  1992 69:A60-A70  DOI:10.1016/0002-9149(92)91172-z
  • Granger, C. B., Califf, R. M., Topol, E. J. Thrombolytic therapy for acute myocardial-infarction - a review Drugs  1992 44:293-325  DOI:10.2165/00003495-199244030-00002  PMID:1382931
  • Doorey, A. J., Michelson, E. L., Topol, E. J. Thrombolytic therapy of acute myocardial-infarction - keeping the unfulfilled promises JAMA-Journal of the American Medical Association  1992 268:3108-3114  DOI:10.1001/jama.268.21.3108  PMID:1433742
  • Lee, P. N. V., Muller, D. W. M., Popma, J. J., Ellis, S. G., Topol, E. J. A comparison of clinical and quantitative angiographic outcomes of coronary stenting in elective and emergency settings: a single center experience Coronary Artery Disease  1991 2:945-951
  • Nabel, E. G., Topol, E. J., Galeana, A., Ellis, S. G., Bates, E. R., Werns, S. W., Walton, J. A., Muller, D. W., Schwaiger, M., Pitt, B. A randomized placebo-controlled trial of combined early intravenous captopril and recombinant tissue-type plasminogen-activator therapy in acute myocardial-infarction Journal of the American College of Cardiology  1991 17:467-473  PMID:1825097
  • Popma, J. J., Topol, E. J. Adjuncts to thrombolysis for myocardial reperfusion Annals of Internal Medicine  1991 115:34-44  PMID:1675557
  • Popma, J. J., Dick, R. J. L., Haudenschild, C. C., Topol, E. J., Ellis, S. G. Atherectomy of right coronary ostial stenoses - initial and long-term results, technical features and histologic-findings American Journal of Cardiology  1991 67:431-434  DOI:10.1016/0002-9149(91)90057-r  PMID:1994670
  • Ellis, S. G., Myler, R. K., King, S. B., Douglas, J. S., Topol, E. J., Shaw, R. E., Stertzer, S. H., Roubin, G. S., Murphy, M. C. Causes and correlates of death after unsupported coronary angioplasty - implications for use of angioplasty and advanced support techniques in high-risk settings American Journal of Cardiology  1991 68:1447-1451  DOI:10.1016/0002-9149(91)90277-r  PMID:1746425
  • Popma, J. J., Decesare, N. B., Ellis, S. G., Holmes, D. R., Pinkerton, C. A., Whitlow, P., King, S. B., Ghazzal, Z. M. B., Topol, E. J., Garratt, K. N., Kereiakes, D. J. Clinical, angiographic and procedural correlates of quantitative coronary dimensions after directional coronary atherectomy Journal of the American College of Cardiology  1991 18:1183-1189  PMID:1918694
  • Schatz, R. A., Goldberg, S., Leon, M., Baim, D., Hirshfeld, J., Cleman, M., Ellis, S., Topol, E. Clinical-experience with the palmaz-schatz coronary stent Journal of the American College of Cardiology  1991 17:B155-B159
  • Schatz, R. A., Baim, D. S., Leon, M., Ellis, S. G., Goldberg, S., Hirshfeld, J. W., Cleman, M. W., Cabin, H. S., Walker, C., Stagg, J., Buchbinder, M., Teirstein, P. S., et al. Clinical-experience with the palmaz-schatz coronary stent - initial results of a multicenter study Circulation  1991 83:148-161  PMID:1984878
  • Kirshenbaum, J. M., Bahr, R. D., Flaherty, J. T., Gurewich, V., Levine, H. J., Loscalzo, J., Schumacher, R. R., Topol, E. J., Wahr, D. W., Braunwald, E. Clot-selective coronary thrombolysis with low-dose synergistic combinations of single-chain urokinase-type plasminogen-activator and recombinant tissue-type plasminogen-activator American Journal of Cardiology  1991 68:1564-1569  DOI:10.1016/0002-9149(91)90310-h  PMID:1746455
  • Muller, D. W. M., Ellis, S. G., Topol, E. J. Colchicine and antineoplastic therapy for the prevention of restenosis after percutaneous coronary interventions Journal of the American College of Cardiology  1991 17:B126-B131
  • Morris, J. A., Muller, D. W. M., Topol, E. J. Combination thrombolytic therapy - a comparison of simultaneous and sequential regimens of tissue plasminogen-activator and urokinase American Heart Journal  1991 122:375-380  DOI:10.1016/0002-8703(91)90988-t  PMID:1907086
  • Clemmensen, P., Bates, E. R., Califf, R. M., Hlatky, M. A., Aronson, L., George, B. S., Lee, K. L., Kereiakes, D. J., Gacioch, G., Berrios, E., Topol, E. J. Complete atrioventricular-block complicating inferior wall acute myocardial-infarction treated with reperfusion therapy American Journal of Cardiology  1991 67:225-230  DOI:10.1016/0002-9149(91)90550-5  PMID:1899319
  • Topol, E. J., Holmes, D. R., Rogers, W. J. Coronary angiography after thrombolytic therapy for acute myocardial-infarction Annals of Internal Medicine  1991 114:877-885  PMID:2014950
  • Kereiakes, D. J., Califf, R. M., George, B. S., Ellis, S., Samaha, J., Stack, R., Martin, L. H., Young, S., Topol, E. J. Coronary-bypass surgery improves global and regional left-ventricular function following thrombolytic therapy for acute myocardial-infarction American Heart Journal  1991 122:390-399  DOI:10.1016/0002-8703(91)90991-p  PMID:1907087
  • Sane, D. C., Stump, D. C., Topol, E. J., Sigmon, K. N., Kereiakes, D. J., George, B. S., Mantell, S. J., Macy, E., Collen, D., Califf, R. M. Correlation between base-line plasminogen-activator inhibitor levels and clinical outcome during therapy with tissue plasminogen-activator for acute myocardial-infarction Thrombosis and Haemostasis  1991 65:275-279  PMID:1904653
  • Ellis, S. G., Cowley, M. J., Disciascio, G., Deligonul, U., Topol, E. J., Bulle, T. M., Vandormael, M. G. Determinants of 2-year outcome after coronary angioplasty in patients with multivessel disease on the basis of comprehensive preprocedural evaluation - implications for patient selection Circulation  1991 83:1905-1914  PMID:2040043
  • Muller, D. W. M., Topol, E. J., Ellis, S. G., Woodlief, L. H., Sigmon, K. N., Kereiakes, D. J., George, B. S., Worley, S. J., Samaha, J. K., Phillips, H., Califf, R. M. Determinants of the need for early acute intervention in patients treated conservatively after thrombolytic therapy for acute myocardial-infarction Journal of the American College of Cardiology  1991 18:1594-1601  PMID:1960302
  • Dick, R. J. L., Haudenschild, C. C., Popma, J. J., Ellis, S. G., Muller, D. W., Topol, E. J. Directional atherectomy for total coronary occlusions Coronary Artery Disease  1991 2:189-199  DOI:10.1097/00019501-199104000-00010
  • Dellborg, M., Topol, E. J., Swedberg, K. Dynamic qrs complex and st segment vectorcardiographic monitoring can identify vessel patency in patients with acute myocardial-infarction treated with reperfusion therapy American Heart Journal  1991 122:943-948  DOI:10.1016/0002-8703(91)90455-q  PMID:1927880
  • Califf, R. M., Topol, E. J., Stack, R. S., Ellis, S. G., George, B. S., Kereiakes, D. J., Samaha, J. K., Worley, S. J., Anderson, J. L., Harrelson-Woodlief, S. L., Wall, T. C., Phillips, H. R., et al. Evaluation of combination thrombolytic therapy and timing of cardiac-catheterization in acute myocardial-infarction - results of thrombolysis and angioplasty in myocardial-infarction phase-5 randomized trial Circulation  1991 83:1543-1556  PMID:1902405
  • Mark, D. B., Sigmon, K., Topol, E. J., Kereiakes, D. J., Pryor, D. B., Candela, R. J., Califf, R. M. Identification of acute myocardial-infarction patients suitable for early hospital discharge after aggressive interventional therapy - results from the thrombolysis and angioplasty in acute myocardial-infarction registry Circulation  1991 83:1186-1193  PMID:2013140
  • Muller, D. W. M., Topol, E. J. Implantable devices in the coronary-artery - from metal to genes Trends in Cardiovascular Medicine  1991 1:225-232  DOI:10.1016/1050-1738(91)90026-b  PMID:21239300
  • Dick, R. J., Popma, J. J., Muller, D. W. M., Burek, K. A., Topol, E. J. In-hospital costs associated with new percutaneous coronary devices American Journal of Cardiology  1991 68:879-885  DOI:10.1016/0002-9149(91)90403-8  PMID:1927947
  • Topol, E. J. Integration of anticoagulation, thrombolysis and coronary angioplasty for unstable angina-pectoris American Journal of Cardiology  1991 68:B136-B141  DOI:10.1016/0002-9149(91)90396-3
  • Bates, E. R., Topol, E. J. Limitations of thrombolytic therapy for acute myocardial-infarction complicated by congestive-heart-failure and cardiogenic-shock Journal of the American College of Cardiology  1991 18:1077-1084  PMID:1894853
  • Muller, D. W. M., Topol, E. J., Ellis, S. G., Sigmon, K. N., Lee, K., Califf, R. M. Multivessel coronary-artery disease - a key predictor of short-term prognosis after reperfusion therapy for acute myocardial-infarction American Heart Journal  1991 121:1042-1049  DOI:10.1016/0002-8703(91)90661-z  PMID:1901190
  • Kereiakes, D. J., Topol, E. J., George, B. S., Stack, R. S., Abbottsmith, C. W., Ellis, S., Candela, R. J., Harrelson, L., Martin, L. H., Califf, R. M. Myocardial-infarction with minimal coronary atherosclerosis in the era of thrombolytic reperfusion Journal of the American College of Cardiology  1991 17:304-312  PMID:1899433
  • Lincoff, A. M., Popma, J. J., Ellis, S. G., Vogel, R. A., Topol, E. J. Percutaneous support devices for high-risk or complicated coronary angioplasty Journal of the American College of Cardiology  1991 17:770-780  PMID:1993799
  • Ellis, S. G., Bates, E. R., Schaible, T., Weisman, H. F., Pitt, B., Topol, E. J. Prospects for the use of antagonists to the platelet glycoprotein-IIb glycoprotein-IIIa receptor to prevent postangioplasty restenosis and thrombosis Journal of the American College of Cardiology  1991 17:B89-B95
  • Sane, D. C., Stump, D. C., Topol, E. J., Sigmon, K. N., Clair, W. K., Kereiakes, D. J., George, B. S., Stoddard, M. F., Bates, E. R., Stack, R. S., Califf, R. M. Racial-differences in responses to thrombolytic therapy with recombinant tissue-type plasminogen-activator - increased fibrin(ogen)olysis in blacks Circulation  1991 83:170-175  PMID:1898641
  • Ellis, S. G., Decesare, N. B., Pinkerton, C. A., Whitlow, P., King, S. B., Ghazzal, Z. M. B., Kereiakes, D. J., Popma, J. J., Menke, K. K., Topol, E. J., Holmes, D. R. Relation of stenosis morphology and clinical presentation to the procedural results of directional coronary atherectomy Circulation  1991 84:644-653  PMID:1860208
  • Sutton, J. M., Topol, E. J. Significance of a negative exercise thallium test in the presence of a critical residual stenosis after thrombolysis for acute myocardial-infarction Circulation  1991 83:1278-1286  PMID:1901529
  • Topol, E. J., Agnelli, G. Strategies for administration of tissue plasminogen-activator Molecular Biology & Medicine  1991 8:219-234  PMID:1806764
  • Stewart, R. E., Kander, N., Juni, J. E., Ellis, S. G., Oneill, W. W., Schork, A., Topol, E. J., Schwaiger, M. Submaximal exercise tl-201 spect for assessment of interventional therapy in patients with acute myocardial-infarction American Heart Journal  1991 121:1033-1041  DOI:10.1016/0002-8703(91)90660-a  PMID:1901189
  • Ohman, E. M., Califf, R. M., George, B. S., Quigley, P. J., Kereiakes, D. J., Harrelson-Woodlief, S. L., Candela, R. J., Flanagan, C., Stack, R. S., Topol, E. J. The use of intraaortic balloon pumping as an adjunct to reperfusion therapy in acute myocardial-infarction American Heart Journal  1991 121:895-901  DOI:10.1016/0002-8703(91)90205-v  PMID:1900381
  • Tenaglia, A. N., Califf, R. M., Candela, R. J., Kereiakes, D. J., Berrios, E., Young, S. Y., Stack, R. S., Topol, E. J. Thrombolytic therapy in patients requiring cardiopulmonary-resuscitation American Journal of Cardiology  1991 68:1015-1019  DOI:10.1016/0002-9149(91)90488-7  PMID:1927913
  • Ellis, S. G., Debowey, D., Bates, E. R., Topol, E. J. Treatment of recurrent ischemia after thrombolysis and successful reperfusion for acute myocardial-infarction - effect on in-hospital mortality and left-ventricular function Journal of the American College of Cardiology  1991 17:752-757  PMID:1993797
  • Topol, E. J. Which thrombolytic agent should one choose Progress in Cardiovascular Diseases  1991 34:165-178  DOI:10.1016/0033-0620(91)90011-a  PMID:1947122
  • Muller, D. W. M., Topol, E. J., George, B. S., Kereiakes, D. J., Aronson, L. G., Lee, K. L., Abbottsmith, C. W., Ellis, S. G., Califf, R. M. 2-year outcome after angiographically documented myocardial reperfusion for acute coronary-occlusion American Journal of Cardiology  1990 66:796-801  DOI:10.1016/0002-9149(90)90354-4  PMID:2220575
  • Kander, N. H., Holland, K. J., Pitt, B., Topol, E. J. A randomized pilot trial of brief versus prolonged heparin after successful reperfusion in acute myocardial-infarction American Journal of Cardiology  1990 65:139-142  DOI:10.1016/0002-9149(90)90074-b  PMID:2404389
  • Popma, J. J., Topol, E. J. Accelerated, combined, and adjunctive thrombolytic strategies for acute myocardial-infarction Current Opinion in Cardiology  1990 5:482-489  DOI:10.1097/00001573-199008000-00017
  • Kavanaugh, K. M., Topol, E. J. Acute intervention during myocardial-infarction in patients with prior coronary-bypass surgery American Journal of Cardiology  1990 65:924-926  DOI:10.1016/0002-9149(90)91440-h  PMID:2321545
  • George, B. S., Candela, R. J., Topol, E. J., Stack, R. S., Kereiakes, D. J., Abbottsmith, C. W., Masek, R., Pickel, A., Dillon, J., Harrelson, L., Califf, R. M. Brachial approach to emergency cardiac-catheterization during thrombolytic therapy for acute myocardial-infarction Catheterization and Cardiovascular Diagnosis  1990 20:221-226  DOI:10.1002/ccd.1810200402  PMID:2119888
  • Topol, E. J. Can thrombolysis be improved? Hospital Formulary  1990 25:19-22
  • Ohman, E. M., Califf, R. M., Topol, E. J., Candela, R., Abbottsmith, C., Ellis, S., Sigmon, K. N., Kereiakes, D., George, B., Stack, R. Consequences of reocclusion after successful reperfusion therapy in acute myocardial-infarction Circulation  1990 82:781-791  PMID:2394002
  • Topol, E. J. Coronary angioplasty in myocardial infarction Hospital Practice  1990 25:73-76, 79  PMID:2109756
  • Samson, M., Sutton, J. M., Topol, E. J., Serruys, P. W. Coronary angioplasty in myocardial-infarction - where are we Annales de Cardiologie et d'Angéiologie  1990 39:371-377  PMID:2205155
  • Ellis, S. G., Vandormael, M. G., Cowley, M. J., Disciascio, G., Deligonul, U., Topol, E. J., Bulle, T. M. Coronary morphological and clinical determinants of procedural outcome with angioplasty for multivessel coronary-disease - implications for patient selection Circulation  1990 82:1193-1202  PMID:2401060
  • Popma, J. J., Topol, E. J. Factors influencing restenosis after coronary angioplasty American Journal of Medicine  1990 88:N16-N24
  • Abbottsmith, C. W., Topol, E. J., George, B. S., Stack, R. S., Kereiakes, D. J., Candela, R. J., Anderson, L. C., Harrelson-Woodlief, S. L. ,, Califf, R. M. Fate of patients with acute myocardial-infarction with patency of the infarct-related vessel achieved with successful thrombolysis versus rescue angioplasty Journal of the American College of Cardiology  1990 16:770-778  PMID:1698843
  • Vogel, R. A., Shawl, F., Tommaso, C., Oneill, W., Overlie, P., Otoole, J., Vandormael, M., Topol, E., Tabari, K. K., Vogel, J., Smith, S., Freedmann, R., et al. Initial report of the national-registry-of-elective-cardiopulmonary bypass supported coronary angioplasty Journal of the American College of Cardiology  1990 15:23-29  PMID:2404047
  • Williams, D. O., Topol, E. J., Califf, R. M., Roberts, R., Mancini, G. B. J., Joelson, J. M., Ellis, S. G., Kleiman, N. S. Intravenous recombinant tissue-type plasminogen-activator in patients with unstable angina-pectoris - results of a placebo-controlled, randomized trial Circulation  1990 82:376-383  PMID:2115407
  • Califf, R. M., Topol, E. J., George, B. S., Kereiakes, D. J., Aronson, L. G., Lee, K. L., Martin, L., Candela, R., Abbottsmith, C., Oneill, W. W., Pryor, D. B., Stack, R. S. One-year outcome after therapy with tissue plasminogen-activator - report from the thrombolysis and angioplasty in myocardial-infarction trial American Heart Journal  1990 119:777-785  DOI:10.1016/s0002-8703(05)80311-4  PMID:2108575
  • Topol, E. J., Wilson, V. E. Pivotal role of early and sustained infarct vessel patency in patients with acute myocardial-infarction Heart & Lung  1990 19:583-595  PMID:2228647
  • Ellis, S. G., Muller, D. W., Topol, E. J. Possible survival benefit from concomitant beta-antagonist but not calcium-antagonist therapy during reperfusion for acute myocardial-infarction American Journal of Cardiology  1990 66:125-128  DOI:10.1016/0002-9149(90)90574-k  PMID:1973588
  • Bates, E. R., Clemmensen, P. M., Califf, R. M., Gorman, L. E., Aronson, L. G., George, B. S., Kereiakes, D. J., Topol, E. J. Precordial st segment depression predicts a worse prognosis in inferior infarction despite reperfusion therapy Journal of the American College of Cardiology  1990 16:1538-1544  PMID:2123903
  • Muller, D. W. M., Ellis, S. G., Debowey, D. L., Topol, E. J. Quantitative angiographic comparison of the immediate success of coronary angioplasty, coronary atherectomy and endoluminal stenting American Journal of Cardiology  1990 66:938-942  DOI:10.1016/0002-9149(90)90929-u  PMID:2220616
  • Muller, D. W. M., Topol, E. J., Califf, R. M., Sigmon, K. N., Gorman, L., George, B. S., Kereiakes, D. J., Lee, K. L., Ellis, S. G. Relationship between antecedent angina-pectoris and short-term prognosis after thrombolytic therapy for acute myocardial-infarction American Heart Journal  1990 119:224-231  DOI:10.1016/s0002-8703(05)80008-0  PMID:2405608
  • Ellis, S. G., Topol, E. J. Results of percutaneous transluminal coronary angioplasty of high-risk angulated stenoses American Journal of Cardiology  1990 66:932-937  DOI:10.1016/0002-9149(90)90928-t  PMID:2220615
  • Muller, D. W. M., Topol, E. J. Selection of patients with acute myocardial-infarction for thrombolytic therapy Annals of Internal Medicine  1990 113:949-960  PMID:2240919
  • Oconnor, C. M., Califf, R. M., Massey, E. W., Mark, D. B., Kereiakes, D. J., Candela, R. J., Abbottsmith, C., George, B., Stack, R. S., Aronson, L., Mantell, S., Topol, E. J. Stroke and acute myocardial-infarction in the thrombolytic era - clinical correlates and long-term prognosis Journal of the American College of Cardiology  1990 16:533-540  PMID:2117618
  • Muller, D. W. M., Topol, E. J. Unresolved issues: late reperfusion, lytic failure, and reocclusion Coronary Artery Disease  1990 1:39-49  DOI:10.1097/00019501-199001000-00007
  • Wall, T. C., Califf, R. M., Harrelson-Woodlief, S. L. ,, Mark, D. B., Honan, M., Abbotsmith, C. W., Candela, R., Berrios, E., Phillips, H. R., Topol, E. J. Usefulness of a pericardial friction rub after thrombolytic therapy during acute myocardial-infarction in predicting amount of myocardial damage American Journal of Cardiology  1990 66:1418-1421  DOI:10.1016/0002-9149(90)90526-7  PMID:2123603
  • Sutton, J. M., Topol, E. J. Usefulness of coronary-artery angioplasty strategies in acute myocardial-infarction Canadian Journal of Cardiology  1990 6:111-122  PMID:2187576
  • Topol, E. J., George, B. S., Kereiakes, D. J., Stump, D. C., Candela, R. J., Abbottsmith, C. W., Aronson, L., Pickel, A., Boswick, J. M., Lee, K. L., Ellis, S. G., Califf, R. M. A randomized controlled trial of intravenous tissue plasminogen-activator and early intravenous heparin in acute myocardial-infarction Circulation  1989 79:281-286  PMID:2492454
  • Muller, D. W. M., Topol, E. J. Acute myocardial infarction: early and late percutaneous trans-luminal coronary angioplasty Current Opinion in Cardiology  1989 4:524-530  DOI:10.1097/00001573-198908000-00012
  • Muller, D. W. M., Ellis, S. G., Topol, E. J. Atherectomy of the left main coronary-artery with percutaneous cardiopulmonary bypass support American Journal of Cardiology  1989 64:114-116  DOI:10.1016/0002-9149(89)90668-1  PMID:2787097
  • Sane, D. C., Califf, R. M., Topol, E. J., Stump, D. C., Mark, D. B., Greenberg, C. S. Bleeding during thrombolytic therapy for acute myocardial-infarction - mechanisms and management Annals of Internal Medicine  1989 111:1010-1022  PMID:2688504
  • Loscalzo, J., Wharton, T. P., Kirshenbaum, J. M., Levine, H. J., Flaherty, J. T., Topol, E. J., Ramaswamy, K., Kosowsky, B. D., Salem, D. N., Ganz, P., Brinker, J. A., Gurewich, V., et al. Clot-selective coronary thrombolysis with pro-urokinase Circulation  1989 79:776-782  PMID:2494004
  • Topol, E. J., Ellis, S. G., Califf, R. M., George, B. S., Stump, D. C., Bates, E. R., Nabel, E. G., Walton, J. A., Candela, R. J., Lee, K. L., Kline, E. M., Pitt, B. Combined tissue-type plasminogen-activator and prostacyclin therapy for acute myocardial-infarction Journal of the American College of Cardiology  1989 14:877-884  PMID:2477426
  • Ellis, S. G., Oneill, W. W., Bates, E. R., Walton, J. A., Nabel, E. G., Topol, E. J. Coronary angioplasty as primary therapy for acute myocardial-infarction 6 to 48 hours after symptom onset - report of an initial experience Journal of the American College of Cardiology  1989 13:1122-1126  PMID:2522467
  • Bates, E. R., Topol, E. J. Early hospital discharge in the myocardial reperfusion era Clinical Cardiology  1989 12:65-70  PMID:2691143
  • Holland, K. J., Oneill, W. W., Bates, E. R., Pitt, B., Topol, E. J. Emergency percutaneous trans-luminal coronary angioplasty during acute myocardial-infarction for patients more than 70 years of age American Journal of Cardiology  1989 63:399-403  DOI:10.1016/0002-9149(89)90307-x  PMID:2521765
  • Burek, K. A., Kirscht, J., Topol, E. J. Exercise capacity in patients 3 days after acute, uncomplicated myocardial-infarction Heart & Lung  1989 18:575-582  PMID:2684916
  • Kereiakes, D. J., Topol, E. J., George, B. S., Abbottsmith, C. W., Stack, R. S., Candela, R. J., Oneill, W. W., Anderson, L. C., Califf, R. M. Favorable early and long-term prognosis following coronary-bypass surgery therapy for myocardial-infarction - results of a multicenter trial American Heart Journal  1989 118:199-207  DOI:10.1016/0002-8703(89)90177-4  PMID:2526573
  • Califf, R. M., Topol, E. J., Gersh, B. J. From myocardial salvage to patient salvage in acute myocardial-infarction - the role of reperfusion therapy Journal of the American College of Cardiology  1989 14:1382-1388  DOI:10.1016/0735-1097(89)90445-2  PMID:2681322
  • Ellis, S. G., Oneill, W. W., Bates, E. R., Walton, J. A., Nabel, E. G., Werns, S. W., Topol, E. J. Implications for patient triage from survival and left-ventricular functional recovery analyses in 500 patients treated with coronary angioplasty for acute myocardial-infarction Journal of the American College of Cardiology  1989 13:1251-1259  PMID:2522954
  • Ellis, S. G., Gallison, L., Grines, C. L., Langburd, A. B., Bates, E. R., Walton, J. A., Oneill, W. W., Topol, E. J. Incidence and predictors of early recurrent ischemia after successful percutaneous trans-luminal coronary angioplasty for acute myocardial-infarction American Journal of Cardiology  1989 63:263-268  DOI:10.1016/0002-9149(89)90327-5  PMID:2521536
  • Ellis, S. G., Topol, E. J. Intracoronary stents - will they fulfill their promise as an adjunct to angioplasty Journal of the American College of Cardiology  1989 13:1425-1430  PMID:2522960
  • Kander, N. H., Oneill, W., Topol, E. J., Gallison, L., Mileski, R., Ellis, S. G. Long-term follow-up of patients treated with coronary angioplasty for acute myocardial-infarction American Heart Journal  1989 118:228-233  DOI:10.1016/0002-8703(89)90180-4  PMID:2526574
  • Stump, D. C., Califf, R. M., Topol, E. J., Sigmon, K., Thornton, D., Masek, R., Anderson, L., Collen, D. Pharmacodynamics of thrombolysis with recombinant tissue-type plasminogen-activator - correlation with characteristics of and clinical outcomes in patients with acute myocardial-infarction Circulation  1989 80:1222-1230  PMID:2509104
  • Grines, C. L., Topol, E. J., Califf, R. M., Stack, R. S., George, B. S., Kereiakes, D., Boswick, J. M., Kline, E., Oneill, W. W. Prognostic implications and predictors of enhanced regional wall motion of the noninfarct zone after thrombolysis and angioplasty therapy of acute myocardial-infarction Circulation  1989 80:245-253  PMID:2526697
  • Nicklas, J. M., Topol, E. J., Kander, N., Oneill, W. W., Walton, J. A., Ellis, S. G., Gorman, L., Pitt, B. Randomized, double-blind, placebo-controlled trial of tissue plasminogen-activator in unstable angina Journal of the American College of Cardiology  1989 13:434-441  PMID:2492325
  • Topol, E. J. Recombinant tissue plasminogen-activator - implications in therapy Seminars in Hematology  1989 26:25-31
  • Ellis, S. G., Topol, E. J., George, B. S., Kereiakes, D. J., Debowey, D., Sigmon, K. N., Pickel, A., Lee, K. L., Califf, R. M. Recurrent ischemia without warning - analysis of risk-factors for in-hospital ischemic events following successful thrombolysis with intravenous tissue plasminogen-activator Circulation  1989 80:1159-1165  PMID:2509102
  • Holmes, D. R., Topol, E. J. Reperfusion momentum - lessons from the randomized trials of immediate coronary angioplasty for myocardial-infarction Journal of the American College of Cardiology  1989 14:1572-1578  DOI:10.1016/0735-1097(89)90401-4  PMID:2809019
  • Ellis, S. G., Shaw, R. E., King, S. B., Myler, R. K., Topol, E. J. Restenosis after excellent angiographic angioplasty result for chronic total coronary-artery occlusion - implications for newer percutaneous revascularization devices American Journal of Cardiology  1989 64:667-668  DOI:10.1016/0002-9149(89)90500-6  PMID:2528903
  • Ellis, S. G., Shaw, R. E., Gershony, G., Thomas, R., Roubin, G. S., Douglas, J. S., Topol, E. J., Startzer, S. H., Myler, R. K., King, S. B. Risk-factors, time course and treatment effect for restenosis after successful percutaneous trans-luminal coronary angioplasty of chronic total occlusion American Journal of Cardiology  1989 63:897-901  DOI:10.1016/0002-9149(89)90135-5  PMID:2522727
  • Gacioch, G. M., Topol, E. J. Sudden paradoxic clinical deterioration during angioplasty of the occluded right coronary-artery in acute myocardial-infarction Journal of the American College of Cardiology  1989 14:1202-1209  DOI:10.1016/0735-1097(89)90418-x  PMID:2808974
  • Chapekis, A. T., Burek, K., Topol, E. J. The cost-benefit ratio of acute intervention for myocardial-infarction - results of a prospective, matched pair analysis American Heart Journal  1989 118:878-882  DOI:10.1016/0002-8703(89)90217-2  PMID:2510487
  • Bates, E. R., Califf, R. M., Stack, R. S., Aronson, L., George, B. S., Candela, R. J., Kereiakes, D. J., Abbottsmith, C. W., Anderson, L., Pitt, B., Oneill, W. W., Topol, E. J. Thrombolysis and angioplasty in myocardial-infarction (tami-1) trial - influence of infarct location on arterial patency, left-ventricular function and mortality Journal of the American College of Cardiology  1989 13:12-18  PMID:2521226
  • Topol, E. J., Burek, K., Oneill, W. W., Kewman, D. G., Kander, N. H., Shea, M. J., Schork, M. A., Kirscht, J., Juni, J. E., Pitt, B. A randomized controlled trial of hospital discharge 3 days after myocardial-infarction in the era of reperfusion New England Journal of Medicine  1988 318:1083-1088  DOI:10.1056/nejm198804283181702  PMID:3281014
  • Topol, E. J. An overview of the thrombolysis and angioplasty in acute myocardial infarction (TAMI) trials Archives Des Maladies Du Coeur Et Des Vaisseaux  1988 81:45-49  PMID:2973302
  • Califf, R. M., Topol, E. J., George, B. S., Boswick, J. M., Lee, K. L., Stump, D., Dillon, J., Abbottsmith, C., Candela, R. J., Kereiakes, D. J., Oneill, W. W., Stack, R. S. Characteristics and outcome of patients in whom reperfusion with intravenous tissue-type plasminogen-activator fails - results of the thrombolysis and angioplasty in myocardial-infarction (tami) i-trial Circulation  1988 77:1090-1099  PMID:2966016
  • Topol, E. J., George, B. S., Kereiakes, D. J., Candela, R. J., Abbottsmith, C. W., Stump, D. C., Boswick, J. M., Stack, R. S., Califf, R. M. Comparison of 2 dose regimens of intravenous tissue plasminogen-activator for acute myocardial-infarction American Journal of Cardiology  1988 61:723-728  DOI:10.1016/0002-9149(88)91055-7  PMID:2965504
  • Grines, C. L., Oneill, W. W., Anselmo, E. G., Juni, J. E., Topol, E. J. Comparison of left-ventricular function and contractile reserve after successful recanalization by thrombolysis versus rescue percutaneous trans-luminal coronary angioplasty for acute myocardial-infarction American Journal of Cardiology  1988 62:352-357  DOI:10.1016/0002-9149(88)90957-5  PMID:2970774
  • Topol, E. J. Coronary angioplasty for acute myocardial-infarction Annals of Internal Medicine  1988 109:970-978  PMID:2973762
  • Topol, E. J., Califf, R. M., George, B. S., Kereiakes, D. J., Rothbaum, D., Candela, R. J., Abbotsmith, C. W., Pinkerton, C. A., Stump, D. C., Collen, D., Lee, K. L., Pitt, B., et al. Coronary arterial thrombolysis with combined infusion of recombinant tissue-type plasminogen-activator and urokinase in patients with acute myocardial-infarction Circulation  1988 77:1100-1107  PMID:2966017
  • Topol, E. J., Nicklas, J. M., Kander, N. H., Walton, J. A., Ellis, S. G., Gorman, L., Pitt, B. Coronary revascularization after intravenous tissue plasminogen-activator for unstable angina-pectoris - results of a randomized, double-blind, placebo-controlled trial American Journal of Cardiology  1988 62:368-371  DOI:10.1016/0002-9149(88)90960-5  PMID:2970776
  • Steinberg, E. P., Topol, E. J., Sakin, J. W., Kahane, S. N., Appel, L. J., Powe, N. R., Anderson, G. F., Erickson, J. E., Guerci, A. D. Cost and procedure implications of thrombolytic therapy for acute myocardial-infarction Journal of the American College of Cardiology  1988 12:A58-A68
  • Kereiakes, D. J., Topol, E. J., George, B. S., Abbottsmith, C. W., Stack, R. S., Candela, R. J., Oneill, W. W., Martin, L. H., Califf, R. M. Emergency coronary-artery bypass-surgery preserves global and regional left-ventricular function after intravenous tissue plasminogen-activator therapy for acute myocardial-infarction Journal of the American College of Cardiology  1988 11:899-907  PMID:2965716
  • Califf, R. M., Oneil, W., Stack, R. S., Aronson, L., Mark, D. B., Mantell, S., George, B. S., Candela, R. J., Kereiakes, D. J., Abbottsmith, C., Topol, E. J. Failure of simple clinical measurements to predict perfusion status after intravenous thrombolysis Annals of Internal Medicine  1988 108:658-662  PMID:3128953
  • Califf, R. M., Topol, E. J., George, B. S., Boswick, J. M., Abbottsmith, C., Sigmon, K. N., Candela, R., Masek, R., Kereiakes, D., Oneill, W. W., Stack, R. S., Stump, D. Hemorrhagic complications associated with the use of intravenous tissue plasminogen-activator in treatment of acute myocardial-infarction American Journal of Medicine  1988 85:353-359  DOI:10.1016/0002-9343(88)90586-4  PMID:3137818
  • Humphrey, L. S., Topol, E. J., Rosenfeld, G. I., Borkon, A. M., Baumgartner, W. A., Gardner, T. J., Maruschak, G., Weiss, J. L. Immediate enhancement of left-ventricular relaxation by coronary-artery bypass-grafting - intraoperative assessment Circulation  1988 77:886-896  PMID:3258195
  • Grines, C. L., Topol, E. J., Bates, E. R., Juni, J. E., Walton, J. A., Oneill, W. W. Infarct vessel status after intravenous tissue plasminogen-activator and acute coronary angioplasty - prediction of clinical outcome American Heart Journal  1988 115:1-7  DOI:10.1016/0002-8703(88)90510-8  PMID:2962478
  • Topol, E. J., Califf, R. M., George, B. S., Kereiakes, D. J., Lee, K. L. Insights derived from the thrombolysis and angioplasty in myocardial-infarction (tami) trials Journal of the American College of Cardiology  1988 12:A24-A31
  • Carlson, S. E., Aldrich, M. S., Greenberg, H. S., Topol, E. J. Intracerebral hemorrhage complicating intravenous tissue plasminogen-activator treatment Archives of Neurology  1988 45:1070-1073  PMID:3140769
  • Stump, D. C., Topol, E. J., Chen, A. B., Hopkins, A., Collen, D. Monitoring of hemostasis parameters during coronary thrombolysis with recombinant tissue-type plasminogen-activator Thrombosis and Haemostasis  1988 59:133-137  PMID:2455358
  • Ellis, S. G., Topol, E. J., Gallison, L., Grines, C. L., Langburd, A. B., Bates, E. R., Walton, J. A., Oneill, W. W. Predictors of success for coronary angioplasty performed for acute myocardial-infarction Journal of the American College of Cardiology  1988 12:1407-1415  PMID:2973481
  • Oneill, W. W., Topol, E. J., Pitt, B. Reperfusion therapy of acute myocardial-infarction Progress in Cardiovascular Diseases  1988 30:235-266  DOI:10.1016/0033-0620(88)90018-7  PMID:3275989
  • Topol, E. J., Morris, D. C., Smalling, R. W., Schumacher, R. R., Taylor, C. R., Nishikawa, A., Liberman, H. A., Collen, D., Tufte, M. E., Grossbard, E. B., Oneill, W. W. A multicenter, randomized, placebo-controlled trial of a new form of intravenous recombinant tissue-type plasminogen-activator (activase) in acute myocardial-infarction Journal of the American College of Cardiology  1987 9:1205-1213  PMID:2953770
  • Topol, E. J., Califf, R. M., George, B. S., Kereiakes, D. J., Abbottsmith, C. W., Candela, R. J., Lee, K. L., Pitt, B., Stack, R. S., Oneill, W. W. A randomized trial of immediate versus delayed elective angioplasty after intravenous tissue plasminogen-activator in acute myocardial-infarction New England Journal of Medicine  1987 317:581-588  DOI:10.1056/nejm198709033171001  PMID:2956516
  • Guerci, A. D., Gerstenblith, G., Brinker, J. A., Chandra, N. C., Gottlieb, S. O., Bahr, R. D., Weiss, J. L., Shapiro, E. P., Flaherty, J. T., Bush, D. E., Chew, P. H., Gottlieb, S. H., et al. A randomized trial of intravenous tissue plasminogen-activator for acute myocardial-infarction with subsequent randomization to elective coronary angioplasty New England Journal of Medicine  1987 317:1613-1618  DOI:10.1056/nejm198712243172601  PMID:2960897
  • Topol, E. J., Oneill, W. W., Langburd, A. B., Walton, J. A., Bourdillon, P. D. V., Bates, E. R., Grines, C. L., Schork, A. M., Kline, E., Pitt, B. A randomized, placebo-controlled trial of intravenous recombinant tissue-type plasminogen-activator and emergency coronary angioplasty in patients with acute myocardial-infarction Circulation  1987 75:420-428  PMID:2948735
  • Topol, E. J. Acute intervention for myocardial-infarction Chest  1987 92:929-932  DOI:10.1378/chest.92.5.929  PMID:2959455
  • Topol, E. J. Advances in thrombolytic therapy for acute myocardial-infarction Journal of Clinical Pharmacology  1987 27:735-745  PMID:3123526
  • Topol, E. J. Clinical use of streptokinase and urokinase therapy for acute myocardial-infarction Heart & Lung  1987 16:760-774  PMID:3316129
  • Topol, E. J., Bates, E. R., Walton, J. A., Baumann, G., Wolfe, S., Maino, J., Bayer, L., Gorman, L., Kline, E. M., Oneill, W. W., Pitt, B. Community-hospital administration of intravenous tissue plasminogen-activator in acute myocardial-infarction - improved timing, thrombolytic efficacy and ventricular-function Journal of the American College of Cardiology  1987 10:1173-1177  PMID:3119685
  • Oneill, W. W., Topol, E. J., Fung, A., Bourdillon, P. D. V., Nicklas, J. M., Walton, J., Bates, E. R., Pitt, B. Coronary angioplasty as therapy for acute myocardial infarction: University of Michigan experience Circulation  1987 76:79-87  PMID:2955959
  • Bates, E. R., Topol, E. J., Kline, E. M., Langburd, A. B., Fung, A. Y., Walton, J. A., Bourdillon, P. D. V., Vogel, R. A., Pitt, B., Oneill, W. W. Early reperfusion therapy improves left-ventricular function after acute inferior myocardial-infarction associated with right coronary-artery disease American Heart Journal  1987 114:261-267  DOI:10.1016/0002-8703(87)90488-1  PMID:2955688
  • Topol, E. J., Juni, J. E., Oneill, W. W., Nicklas, J. M., Shea, M. J., Burek, K., Pitt, B. Exercise testing 3 days after onset of acute myocardial-infarction American Journal of Cardiology  1987 60:958-962  DOI:10.1016/0002-9149(87)90332-8  PMID:2960230
  • Topol, E. J., Ellis, S. G., Fishman, J., Leimgruber, P., Myler, R. K., Stertzer, S. H., Oneill, W. W., Douglas, J. S., Roubin, G. S., King, S. B. Multicenter study of percutaneous trans-luminal angioplasty for right coronary-artery ostial stenosis Journal of the American College of Cardiology  1987 9:1214-1218  PMID:2953771
  • Myler, R. K., Topol, E. J., Shaw, R. E., Stertzer, S. H., Clark, D. A., Fishman, J., Murphy, M. C. Multiple vessel coronary angioplasty - classification, results, and patterns of restenosis in 494 consecutive patients Catheterization and Cardiovascular Diagnosis  1987 13:1-15  DOI:10.1002/ccd.1810130102  PMID:2949849
  • Kircher, B. J., Topol, E. J., Oneill, W. W., Pitt, B. Prediction of infarct coronary-artery recanalization after intravenous thrombolytic therapy American Journal of Cardiology  1987 59:513-515  DOI:10.1016/0002-9149(87)91158-1  PMID:3825886
  • Wind, B. E., Snider, A. R., Buda, A. J., Oneill, W. W., Topol, E. J., Dilworth, L. R. Pulsed doppler assessment of left-ventricular diastolic filling in coronary-artery disease before and immediately after coronary angioplasty American Journal of Cardiology  1987 59:1041-1046  DOI:10.1016/0002-9149(87)90845-9  PMID:2953227
  • Papadopoulos, S. M., Chandler, W. F., Salamat, M. S., Topol, E. J., Sackellares, J. C. Recombinant human tissue-type plasminogen-activator therapy in acute thromboembolic stroke Journal of Neurosurgery  1987 67:394-398  DOI:10.3171/jns.1987.67.3.0394  PMID:3112328
  • Topol, E. J., Califf, R. M., Kereiakes, D. J., George, B. S. Thrombolysis and angioplasty in myocardial-infarction (tami) trial Journal of the American College of Cardiology  1987 10:B65-B74
  • Walsh, D. G., Kaplan, L. R., Burney, R. E., Topol, E. J., Oneill, W. W. Use of tissue plasminogen-activator in the emergency department for acute myocardial-infarction Annals of Emergency Medicine  1987 16:243-247  DOI:10.1016/s0196-0644(87)80166-x  PMID:2949679
  • Sanz, M. L., Mancini, J., Lefree, M. T., Mickelson, J. K., Starling, M. R., Vogel, R. A., Topol, E. J. Variability of quantitative digital subtraction coronary angiography before and after percutaneous trans-luminal coronary angioplasty American Journal of Cardiology  1987 60:55-60  DOI:10.1016/0002-9149(87)90984-2  PMID:2955693
  • Topol, E. J., Biern, R. O., Reitz, B. A. Cardiac papillary fibroelastoma and stroke - echocardiographic diagnosis and guide to excision American Journal of Medicine  1986 80:129-132  DOI:10.1016/0002-9343(86)90063-x  PMID:3942145
  • Topol, E. J., Lerman, B. B., Baughman, K. L., Platia, E. V., Griffith, L. S. C. Denovo refractory ventricular tachyarrhythmias after coronary revascularization American Journal of Cardiology  1986 57:57-59  DOI:10.1016/0002-9149(86)90951-3  PMID:3484603
  • Topol, E. J., Herskowitz, A., Hutchins, G. M. Massive hemorrhagic myocardial-infarction after coronary thrombolysis American Journal of Medicine  1986 81:339-343  DOI:10.1016/0002-9343(86)90275-5  PMID:3090880
  • Topol, E. J., Fung, A. Y., Kline, E., Kaplan, L., Landis, D., Strozeski, M., Burney, R. E., Pitt, B., Oneill, W. W. Safety of helicopter transport and out-of-hospital intravenous fibrinolytic therapy in patients with evolving myocardial-infarction Catheterization and Cardiovascular Diagnosis  1986 12:151-155  PMID:3089627
  • Fung, A. Y., Lai, P., Topol, E. J., Bates, E. R., Bourdillon, P. D. V., Walton, J. A., Mancini, G. B. J., Kryski, T., Pitt, B., Oneill, W. W. Value of percutaneous trans-luminal coronary angioplasty after unsuccessful intravenous streptokinase therapy in acute myocardial-infarction American Journal of Cardiology  1986 58:686-691  DOI:10.1016/0002-9149(86)90338-3  PMID:2945418
  • Topol, E. J., Eha, J. E., Brin, K. P., Shapiro, E. P., Weiss, J. L., Riegel, M. B., Gottlieb, S. O., Brinker, J. A. Applicability of percutaneous trans-luminal coronary angioplasty to patients with recombinant tissue plasminogen-activator mediated thrombolysis Catheterization and Cardiovascular Diagnosis  1985 11:337-348  DOI:10.1002/ccd.1810110402  PMID:2931176
  • Topol, E. J., Bell, W. R., Weisfeldt, M. L. Coronary thrombolysis with recombinant tissue-type plasminogen-activator - a hematologic and pharmacologic study Annals of Internal Medicine  1985 103:837-843  PMID:3933395
  • Topol, E. J., Traill, T. A., Fortuin, N. J. Hypertensive hypertrophic cardiomyopathy of the elderly New England Journal of Medicine  1985 312:277-283  DOI:10.1056/nejm198501313120504  PMID:2857050
  • Topol, E. J., Weiss, J. L., Brinker, J. A., Brin, K. P., Gottlieb, S. O., Becker, L. C., Bulkley, B. H., Chandra, N., Flaherty, J. T., Gerstenblith, G., Gottlieb, S. H., Guerci, A. D., et al. Regional wall motion improvement after coronary thrombolysis with recombinant tissue plasminogen-activator - importance of coronary angioplasty Journal of the American College of Cardiology  1985 6:426-433  PMID:3160757
  • Topol, E. J., Myler, R. K., Stertzer, S. H. Selection of dilatation hardware for ptca - 1985 Catheterization and Cardiovascular Diagnosis  1985 11:629-637  DOI:10.1002/ccd.1810110613  PMID:2936462
  • Topol, E. J., Ciuffo, A. A., Pearson, T. A., Dillman, J., Builder, S., Grossbard, E., Weisfeldt, M. L., Bulkley, B. H. Thrombolysis with recombinant tissue plasminogen-activator in atherosclerotic thrombotic occlusion Journal of the American College of Cardiology  1985 5:85-91  PMID:4038373
  • Topol, E. J., Humphrey, L. S., Borkon, A. M., Baumgartner, W. A., Dorsey, D. L., Reitz, B. A., Weiss, J. L. Value of intraoperative left-ventricular microbubbles detected by trans-esophageal two-dimensional echocardiography in predicting neurologic outcome after cardiac operations American Journal of Cardiology  1985 56:773-775  DOI:10.1016/0002-9149(85)91134-8  PMID:4061300
  • Collen, D., Topol, E. J., Tiefenbrunn, A. J., Gold, H. K., Weisfeldt, M. L., Sobel, B. E., Leinbach, R. C., Brinker, J. A., Ludbrook, P. A., Yasuda, I., Bulkley, B. H., Robison, A. K., et al. Coronary thrombolysis with recombinant human tissue-type plasminogen-activator - a prospective, randomized, placebo-controlled trial Circulation  1984 70:1012-1017  PMID:6388898
  • Topol, E. J., Fortuin, N. J. Coronary-artery spasm and cardiac-arrest in carcinoid heart-disease American Journal of Medicine  1984 77:950-952  DOI:10.1016/0002-9343(84)90549-7  PMID:6496552
  • Topol, E. J., Weiss, J. L., Guzman, P. A., Dorseylima, S., Blanck, T. J. J., Humphrey, L. S., Baumgartner, W. A., Flaherty, J. T., Reitz, B. A. Immediate improvement of dysfunctional myocardial segments after coronary revascularization - detection by intraoperative trans-esophageal echocardiography Journal of the American College of Cardiology  1984 4:1123-1134  PMID:6334108
  • Lerman, B. B., Topol, E. J., Platia, E. V., Baughman, K. L. Orthostatic atrial tachycardia - autonomic influence on atrial pacemakers American Journal of Cardiology  1984 53:1406-1408  DOI:10.1016/0002-9149(84)90105-x  PMID:6711447
  • Topol, E. J., Lerman, B. B. Hypomagnesemic torsades de pointes American Journal of Cardiology  1983 52:1367-1368  DOI:10.1016/0002-9149(83)90611-2  PMID:6650429
  • Topol, E. J., Goldschlager, N., Ports, T. A., Dicarlo, L. A., Schiller, N. B., Botvinick, E. H., Chatterjee, K. Hemodynamic benefit of atrial-pacing in right ventricular myocardial-infarction Annals of Internal Medicine  1982 96:594-597  PMID:7073152
  • Moss, A. J., Glaser, W., Topol, E. Atrial tachypacing in the treatment of a patient with primary orthostatic hypotension New England Journal of Medicine  1980 302:1456-1457  DOI:10.1056/nejm198006263022606  PMID:7374710
  • Topol, E., Brodows, R. G. Effects of indomethacin on acute insulin release in man Diabetes  1980 29:379-382  DOI:10.2337/diabetes.29.5.379  PMID:6769727
  • Delihas, N., Topol, E., Larrinua, I. Changes in accessibility to chemical modification of escherichia-coli ribosomes induced by streptomycin FEBS Letters  1975 53:170-175  DOI:10.1016/0014-5793(75)80012-3  PMID:1095412

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  • Topol, E. J., Califf, R. M. Textbook of cardiovascular medicine Philadelphia: Lippincott Williams & Wilkins. 2007

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  • TSRI Awarded $20M for First Year of US Precision Medicine Initiative Cohort Program 2016