Thomas, Elizabeth

Faculty Member

Positions

2017 - Associate Professor, Neuroscience , Scripps Research
2006 - Honorary Senior Research Fellow, Mental Health Research Institute (Melbourne)
2013 - 2017 Associate Professor, Molecular and Cellular Neuroscience (MCN) , Scripps Research
2009 - 2012 Associate Professor, Molecular Biology , Scripps Research
2002 - 2009 Assistant Professor, Molecular Biology , Scripps Research
1998 - 2002 Senior Research Associate, Molecular Biology , Scripps Research
1995 - 1998 Research Associate, Molecular Biology , Scripps Research

Dr. Elizabeth Thomas investigates the molecular neurobiology of psychiatric and neurodegenerative disorders, such as schizophrenia, bipolar disorder, and Huntington's disease, so that they can be better diagnosed and treated.

Research Areas

Mental Illness (UMLS)

Contact

bthomas@scripps.edu

Websites

Publications
Research
Background
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recent publications

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Publications without PubMed PMIDs

academic article
- Corey-Bloom, J., Haque, A., Aboufadel, S., Snell, C., Fischer, R. S., Granger, S. W., Granger, D. A., Thomas, E. A. Uric acid as a potential peripheral biomarker for disease features in Huntington's patients Frontiers in Neuroscience 2020 14 DOI:10.3389/fnins.2020.00073 PMID:32194366 PMCID:PMC7065265
- Gutierrez, A., Corey-Bloom, J., Thomas, E. A., Desplats, P. Evaluation of biochemical and epigenetic measures of peripheral brain-derived neurotrophic factor (BDNF) as a biomarker in Huntington's disease patients Frontiers in Molecular Neuroscience 2020 12 DOI:10.3389/fnmol.2019.00335 PMID:32038165 PMCID:PMC6989488
- Corey-Bloom, J., Haque, A. S., Park, S., Nathan, A. S., Baker, R. W., Thomas, E. A. Salivary levels of total huntingtin are elevated in Huntington's disease patients Scientific Reports 2018 8 DOI:10.1038/s41598-018-25095-3 PMID:29743609 PMCID:PMC5943337
- Thomas, E. A., D'Mello, S. R. Complex neuroprotective and neurotoxic effects of histone deacetylases Journal of Neurochemistry 2018 145:96-110 DOI:10.1111/jnc.14309 PMID:29355955 PMCID:PMC5920706
- Dean, B., Gibbons, A., Gogos, A., Udawela, M., Thomas, E., Scarr, E. Studies on prostaglandin-endoperoxide synthase 1: lower levels in schizophrenia and after treatment with antipsychotic drugs in conjunction with aspirin International Journal of Neuropsychopharmacology 2018 21:216-225 DOI:10.1093/ijnp/pyx092 PMCID:PMC5838806
- Corey-Bloom, J., Aikin, A. M., Gutierrez, A. M., Nadhem, J. S., Howell, T. L., Thomas, E. A. Beneficial effects of glatiramer acetate in Huntington's disease mouse models: Evidence for BDNF-elevating and immunomodulatory mechanisms Brain Research 2017 1673:102-110 DOI:10.1016/j.brainres.2017.08.013 PMID:28823953 PMCID:PMC5595665
- Thomas, E. A. Histone posttranslational modifications in schizophrenia Advances in Experimental Medicine and Biology 2017 978:237-254 DOI:10.1007/978-3-319-53889-1_13 PMID:28523550
- Thomas, E. A. DNA methylation in Huntington's disease: Implications for transgenerational effects Neuroscience Letters 2016 625:34-39 DOI:10.1016/j.neulet.2015.10.060 PMID:26522374 PMCID:PMC4864163
- Jia, H., Wang, Y., Morris, C. D., Jacques, V., Gottesfeld, J. M., Rusche, J. R., Thomas, E. A. The effects of pharmacological inhibition of histone deacetylase 3 (HDAC3) in Huntington's disease mice PLoS One 2016 11 DOI:10.1371/journal.pone.0152498 PMID:27031333 PMCID:PMC4816519
- Scarr, E., Udawela, M., Greenough, M. A., Neo, J., Suk Seo, M., Money, T. T., Upadhyay, A., Bush, A. I., Everall, I. P., Thomas, E. A., Dean, B. Increased cortical expression of the zinc transporter SLC39A12 suggests a breakdown in zinc cellular homeostasis as part of the pathophysiology of schizophrenia NPJ Schizophrenia 2016 2 DOI:10.1038/npjschz.2016.2 PMID:27336053 PMCID:PMC4898896
- Scarr, E., Udawela, M., Thomas, E. A., Dean, B. Changed gene expression in subjects with schizophrenia and low cortical muscarinic M1 receptors predicts disrupted upstream pathways interacting with that receptor Molecular Psychiatry 2016 23:295-303 DOI:10.1038/mp.2016.195 PMID:27801890 PMCID:PMC5794886
- Jia, H., Morris, C. D., Williams, R. M., Loring, J. F., Thomas, E. A. HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation Proceedings of the National Academy of Sciences of the United States of America 2015 112:E56-E64 DOI:10.1073/pnas.1415195112 PMID:25535382 PMCID:PMC4291662
- Corey-Bloom, J., Jia, H., Aikin, A. M., Thomas, E. A. Disease modifying potential of glatiramer acetate in Huntington's disease Journal of Huntington's Disease 2014 3:311-316 DOI:10.3233/jhd-140110 PMID:25300334 PMCID:PMC4480978
- Thomas, E. A. Involvement of HDAC1 and HDAC3 in the pathology of polyglutamine disorders: therapeutic implications for selective HDAC1/HDAC3 inhibitors Pharmaceuticals (Basel) 2014 7:634-661 DOI:10.3390/ph7060634 PMID:24865773 PMCID:PMC4078513
- Unterwald, E. M., Page, M. E., Brown, T. B., Miller, J. S., Ruiz, M., Pescatore, K. A., Xu, B., Reichardt, L. F., Beverley, J., Tang, B., Steiner, H., Thomas, E. A., et al. Behavioral and transcriptome alterations in male and female mice with postnatal deletion of TrkB in dorsal striatal medium spiny neurons Molecular Neurodegeneration 2013 8:47 DOI:10.1186/1750-1326-8-47 PMID:24369067 PMCID:PMC3880973
- Tang, B., Jia, H., Kast, R. J., Thomas, E. A. Epigenetic changes at gene promoters in response to immune activation in utero Brain Behavior and Immunity 2013 30:168-175 DOI:10.1016/j.bbi.2013.01.086 PMID:23402795
- Jia, H. Q., Kast, R. J., Steffan, J. S., Thomas, E. A. Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: Implications for the ubiquitin-proteasomal and autophagy systems Human Molecular Genetics 2012 21:5280-5293 DOI:10.1093/hmg/dds379 PMID:22965876 PMCID:PMC3510756
- Tang, B., Becanovic, K., Desplats, P. A., Spencer, B., Hill, A. M., Connolly, C., Masliah, E., Leavitt, B. R., Thomas, E. A. Forkhead box protein p1 is a transcriptional repressor of immune signaling in the cns: Implications for transcriptional dysregulation in huntington disease Human Molecular Genetics 2012 21:3097-3111 DOI:10.1093/hmg/dds132 PMID:22492998 PMCID:PMC3384380
- Keilani, S., Chandwani, S., Dolios, G., Bogush, A., Beck, H., Hatzopoulos, A. K., Rao, G. N., Thomas, E. A., Wang, R., Ehrlich, M. E. Egr-1 induces darpp-32 expression in striatal medium spiny neurons via a conserved intragenic element Journal of Neuroscience 2012 32:6808-6818 DOI:10.1523/jneurosci.5448-11.2012 PMID:22593050
- Jia, H. Q., Pallos, J., Jacques, V., Lau, A., Tang, B., Cooper, A., Syed, A., Purcell, J., Chen, Y., Sharma, S., Sangrey, G. R., Darnell, S. B., et al. Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of huntington's disease Neurobiology of Disease 2012 46:351-361 DOI:10.1016/j.nbd.2012.01.016 PMID:22590724 PMCID:PMC3528106
- Tang, B., Capitao, C., Dean, B., Thomas, E. A. Differential age- and disease-related effects on the expression of genes related to the arachidonic acid signaling pathway in schizophrenia Psychiatry Research 2012 196:201-206 DOI:10.1016/j.psychres.2011.09.026 PMID:22397921 PMCID:PMC3361581
- Thomas, E. A. Transcriptomics of antipsychotic drug function: What have we learned from rodent studies? Current Psychopharmacology 2012 1:272-283
- Tang, B., Dean, B., Thomas, E. A. Disease- and age-related changes in histone acetylation at gene promoters in psychiatric disorders Translational Psychiatry 2011 1:e64 DOI:10.1038/tp.2011.61 PMID:22832356 PMCID:PMC3305989
- Tang, B., Di Lena, P., Schaffer, L., Head, S. R., Baldi, P., Thomas, E. A. Genome-wide identification of bcl11b gene targets reveals role in brain-derived neurotrophic factor signaling PLoS One 2011 6:e23691 DOI:10.1371/journal.pone.0023691 PMID:21912641 PMCID:PMC3164671
- Tang, B., Seredenina, T., Coppola, G., Kuhn, A., Geschwind, D. H., Luthi-Carter, R., Thomas, E. A. Gene expression profiling of r6/2 transgenic mice with different cag repeat lengths reveals genes associated with disease onset and progression in huntington's disease Neurobiology of Disease 2011 42:459-467 DOI:10.1016/j.nbd.2011.02.008 PMID:21334439 PMCID:PMC3079804
- Sutcliffe, J. G., Hedlund, P. B., Thomas, E. A., Bloom, F. E., Hilbush, B. S. Peripheral reduction of beta-amyloid is sufficient to reduce brain beta-amyloid: Implications for alzheimer's disease Journal of Neuroscience Research 2011 89:808-814 DOI:10.1002/jnr.22603 PMID:21374699
- Thomas, E. A., Coppola, G., Tang, B., Kuhn, A., Kim, S., Geschwind, D. H., Brown, T. B., Luthi-Carter, R., Ehrlich, M. E. In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons Human Molecular Genetics 2011 20:1049-1060 DOI:10.1093/hmg/ddq548 PMID:21177255 PMCID:PMC3043657
- Udawela, M., Scarr, E., Hannan, A. J., Thomas, E. A., Dean, B. Phospholipase c beta 1 expression in the dorsolateral prefrontal cortex from patients with schizophrenia at different stages of illness Australian and New Zealand Journal of Psychiatry 2011 45:140-147 DOI:10.3109/00048674.2010.533364 PMID:21091263
- Narayan, S., Thomas, E. A. Sphingolipid abnormalities in psychiatric disorders: a missing link in pathology? Frontiers in Bioscience 2011 16:1797-1810 DOI:10.2741/3822 PMID:21196265
- Ku, S., Soragni, E., Campau, E., Thomas, E. A., Altun, G., Laurent, L. C., Loring, J. F., Napierala, M., Gottesfeld, J. M. Friedreich's ataxia induced pluripotent stem cells model intergenerational GAA.TTC triplet repeat instability Cell Stem Cell 2010 7:631-637 DOI:10.1016/j.stem.2010.09.014 PMID:21040903 PMCID:PMC2987635
- Denny, C. A., Desplats, P. A., Thomas, E. A., Seyfried, T. N. Cerebellar lipid differences between r6/1 transgenic mice and humans with huntington's disease Journal of Neurochemistry 2010 115:748-758 DOI:10.1111/j.1471-4159.2010.06964.x PMID:20731757
- Schlosburg, J. E., Blankman, J. L., Long, J. Z., Nomura, D. K., Pan, B., Kinsey, S. G., Nguyen, P. T., Ramesh, D., Booker, L., Burston, J. J., Thomas, E. A., Selley, D. E., et al. Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system Nature Neuroscience 2010 13:1113-1119 DOI:10.1038/nn.2616 PMID:20729846 PMCID:PMC2928870
- Perdomo, G., Kim, D. H., Zhang, T., Thomas, E. A., Toledo, F. G. S., Slusher, S., Fan, Y., Kelley, D. E., Dong, H. H., Qu, S. A role of apolipoprotein D in triglyceride metabolism Journal of Lipid Research 2010 51:1298-1311 DOI:10.1194/jlr.M001206 PMID:20124557 PMCID:PMC3035493
- Torkamani, A., Dean, B., Schork, N. J., Thomas, E. A. Coexpression network analysis of neural tissue reveals perturbations in developmental processes in schizophrenia Genome Research 2010 20:403-412 DOI:10.1101/gr.101956.109 PMID:20197298 PMCID:PMC2847743
- Gibbons, A. S., Thomas, E. A., Scarr, E., Dean, B. Low density lipoprotein receptor-related protein and apolipoprotein E expression is altered in schizophrenia Front Psychiatry 2010 1 DOI:10.3389/fpsyt.2010.00019 PMID:21423430 PMCID:PMC3059617
- Thomas, E. A. Focal nature of neurological disorders necessitates isotype-selective histone deacetylase (hdac) inhibitors Molecular Neurobiology 2009 40:33-45 DOI:10.1007/s12035-009-8067-y PMID:19396637
- Gibbons, A. S., Thomas, E. A., Dean, B. Regional and duration of illness differences in the alteration of ncam-180 mrna expression within the cortex of subjects with schizophrenia Schizophrenia Research 2009 112:65-71 DOI:10.1016/j.schres.2009.04.002 PMID:19411161 PMCID:PMC2722680
- Tang, B., Chang, W. L., Lanigan, C. M., Dean, B., Sutcliffe, J. G., Thomas, E. A. Normal human aging and early-stage schizophrenia share common molecular profiles Aging Cell 2009 8:339-342 DOI:10.1111/j.1474-9726.2009.00468.x PMID:19245676 PMCID:PMC2695825
- Thomas, E. A. Selective HDAC inhibitors: Promising treatment for Huntington's disease Bioforum Europe 2009 13:32-34
- Narayan, S., Head, S. R., Gilmartin, T. J., Dean, B., Thomas, E. A. Evidence for disruption of sphingolipid metabolism in schizophrenia Journal of Neuroscience Research 2009 87:278-288 DOI:10.1002/jnr.21822 PMID:18683247 PMCID:PMC2606914
- Narayan, S., Tang, B., Head, S. R., Gilmartin, T. J., Sutcliffe, J. G., Dean, B., Thomas, E. A. Molecular profiles of schizophrenia in the cns at different stages of illness Brain Research 2008 1239:235-248 DOI:10.1016/j.brainres.2008.08.023 PMID:18778695 PMCID:PMC2783475
- Thomas, E. A., Coppola, G., Desplats, P. A., Tang, B., Soragni, E., Burnett, R., Gao, F. Y., Fitzgerald, K. M., Borok, J. F., Herman, D., Geschwind, D. H., Gottesfeld, J. M. The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice Proceedings of the National Academy of Sciences of the United States of America 2008 105:15564-15569 DOI:10.1073/pnas.0804249105 PMID:18829438 PMCID:PMC2563081
- Desplats, P. A., Lambert, J. R., Thomas, E. A. Functional roles for the striatal-enriched transcription factor, bcl11b, in the control of striatal gene expression and transcriptional dysregulation in huntington's disease Neurobiology of Disease 2008 31:298-308 DOI:10.1016/j.nbd.2008.05.005 PMID:18595722 PMCID:PMC2569875
- Dean, B., Digney, A., Sundram, S., Thomas, E., Scarr, E. Plasma apolipoprotein E is decreased in schizophrenia spectrum and bipolar disorder Psychiatry Research 2008 158:75-78 DOI:10.1016/j.psychres.2007.05.008 PMID:18096247
- Gibbons, A. S., Scarr, E., McOmish, C. E., Hannan, A. J., Thomas, E. A., Dean, B. Regulator of g-protein signalling 4 expression is not altered in the prefrontal cortex in schizophrenia Australian and New Zealand Journal of Psychiatry 2008 42:740-745 PMID:18622782
- Desplats, P. A., Denny, C. A., Kass, K. E., Gilmartin, T., Head, S. R., Sutcliffe, J. G., Seyffied, T. N., Thomas, E. A. Glycolipid and ganglioside metabolism imbalances in huntington's disease Neurobiology of Disease 2007 27:265-277 DOI:10.1016/j.nbd.2007.05.003 PMID:17600724 PMCID:PMC2082128
- Dean, B., Keriakous, D., Scarr, E., Thomas, E. A. Gene expression profiling in Brodmann's area 46 from subjects with schizophrenia The Australian and New Zealand Journal of Psychiatry 2007 41:308-320 DOI:10.1080/00048670701213245 PMID:17464717
- Narayan, S., Kass, K. E., Thomas, E. A. Chronic haloperidol treatment results in a decrease in the expression of myelin/oligodendrocyte-related genes in the mouse brain Journal of Neuroscience Research 2007 85:757-765 DOI:10.1002/jnr.21161 PMID:17177202
- Thomas, E. A., Yao, J. K. Clozapine specifically alters the arachidonic acid pathway in mice lacking apolipoprotein d Schizophrenia Research 2007 89:147-153 DOI:10.1016/j.schres.2006.08.011 PMID:17011169
- Thomas, E. A. Striatal specificity of gene expression dysregulation in huntington's disease Journal of Neuroscience Research 2006 84:1151-1164 DOI:10.1002/jnr.21046 PMID:16983659
- Thomas, E. A. Molecular profiling of antipsychotic drug function: convergent mechanisms in the pathology and treatment of psychiatric disorders Molecular Neurobiology 2006 34:109-128 DOI:10.1385/mn:34:2:109 PMID:17220533
- Desplats, P. A., Kass, K. E., Gilmartin, T., Stanwood, G. D., Woodward, E. L., Head, S. R., Sutcliffe, J. G., Thomas, E. A. Selective deficits in the expression of striatal-enriched mrnas in huntington's disease Journal of Neurochemistry 2006 96:743-757 DOI:10.1111/j.1471-4159.2005.03588.x PMID:16405510
- Ziolkowska, B., Gieryk, A., Bilecki, W., Wawrzczak-Bargiela, A., Wedzony, K., Chocyk, A., Danielson, P. E., Thomas, E. A., Hilbush, B. S., Sutcliffe, J. G., Przewlocki, R. Regulation of alpha-synuclein expression in limbic and motor brain regions of morphine-treated mice Journal of Neuroscience 2005 25:4996-5003 DOI:10.1523/jneurosci.4376-04.2005 PMID:15901780
- Digney, A., Keriakous, D., Scarr, E., Thomas, E., Dean, B. Differential changes in apolipoprotein E in schizophrenia and bipolar I disorder Biological Psychiatry 2005 57:711-715 DOI:10.1016/j.biopsych.2004.12.028 PMID:15820227
- Dean, B., Keriakous, D., Thomas, E., Scarr, E. Understanding the pathology of schizophrenia: The impact of high- throughput screening of the genome and proteome in postmortem CNS Current Psychiatry Reviews 2005 1:1-9 DOI:10.2174/1573400052953547
- Yao, J. K., Thomas, E. A., Reddy, R. D., Keshavan, M. S. Association of plasma apolipoproteins d with rbc membrane arachidonic acid levels in schizophrenia Schizophrenia Research 2005 72:259-266 DOI:10.1016/j.schres.2004.05.007 PMID:15560970
- Thomas, E. A., George, R. C., Sutcliffe, J. G. Apolipoprotein d modulates arachidonic acid signaling in cultured cells: Implications for psychiatric disorders Prostaglandins Leukotrienes and Essential Fatty Acids 2003 69:421-427 DOI:10.1016/j.plefa.2003.08.014 PMID:14623496
- Dean, B., Laws, S. M., Hone, E., Taddei, K., Scarr, E., Thomas, E. A., Harper, C., McClean, C., Masters, C., Lautenschlager, N., Gandy, S. E., Martins, R. N. Increased levels of apolipoprotein e in the frontal cortex of subjects with schizophrenia Biological Psychiatry 2003 54:616-622 DOI:10.1016/s0006-3223(03)00075-1 PMID:13129656
- Thomas, E. A., Copolov, D. L., Sutcliffe, J. G. From pharmacotherapy to pathophysiology: Emerging mechanisms of apolipoprotein d in psychiatric disorders Current Molecular Medicine 2003 3:408-418 DOI:10.2174/1566524033479681 PMID:12942994
- Thomas, E. A., Laws, S. M., Sutcliffe, J. G., Harper, C., Dean, B., McClean, C., Masters, C., Lautenschlager, N., Gandy, S. E., Martins, R. N. Apolipoprotein d levels are elevated in prefrontal cortex of subjects with alzheimer's disease: No relation to apolipoprotein e expression or genotype Biological Psychiatry 2003 54:136-141 DOI:10.1016/s0006-3223(02)01976-5 PMID:12873803
- Hedlund, P. B., Danielson, P. E., Thomas, E. A., Slanina, K., Carson, M. J., Sutcliffe, J. G. No hypothermic response to serotonin in 5-ht7 receptor knockout mice Proceedings of the National Academy of Sciences of the United States of America 2003 100:1375-1380 DOI:10.1073/pnas.0337340100 PMID:12529502 PMCID:PMC298780
- Thomas, E. A., George, R. C., Danielson, P. E., Nelson, P. A., Warren, A. J., Lo, D., Sutcliffe, J. G. Antipsychotic drug treatment alters expression of mrnas encoding lipid metabolism-related proteins Molecular Psychiatry 2003 8:983-993 DOI:10.1038/sj.mp.4001425 PMID:14647396
- Thomas, E. A., Dean, B., Scarr, E., Copolov, D., Sutcliffe, J. G. Differences in neuroanatomical sites of apod elevation discriminate between schizophrenia and bipolar disorder Molecular Psychiatry 2003 8:167-175 DOI:10.1038/sj.mp.4001223 PMID:12610649
- Thomas, E. A., Sutcliffe, J. G. The neuirobiology of apolipoproteins in psychiatric disorders Molecular Neurobiology 2002 26:369-388 DOI:10.1385/mn:26:2-3:369 PMID:12428765
- Alvarez, C. E., Sutcliffe, J. G., Thomas, E. A. Novel isoform of insulin receptor substrate p53/p58 is generated by alternative splicing in the crib/sh3-binding region Journal of Biological Chemistry 2002 277:24728-24734 DOI:10.1074/jbc.M20512200 PMID:12006592
- Nelson, P. A., Sutcliffe, J. G., Thomas, E. A. A new UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase mRNA exhibits predominant expression in the hypothalamus, thalamus and amygdala of mouse forebrain Brain Research. Gene Expression Patterns 2002 1:95-99 PMID:15018805
- Thomas, E. A., Sautkulis, L. N., Criado, J. R., Games, D., Sutcliffe, J. G. Apolipoprotein d mrna expression is elevated in pdapp transgenic mice Journal of Neurochemistry 2001 79:1059-1064 DOI:10.1046/j.1471-4159.2001.00654.x PMID:11739619
- Thomas, E. A., Foye, P. E., Alvarez, C. E., Usui, H., Sutcliffe, J. G. Insulin receptor substrate protein p53 localization in rats suggests mechanism for specific polyglutamine neurodegeneration Neuroscience Letters 2001 309:145-148 DOI:10.1016/s0304-3940(01)02064-x PMID:11514062
- Thomas, E. A., Dean, B., Pavey, G., Sutcliffe, J. G. Increased cns levels of apolipoprotein d in schizophrenic and bipolar subjects: Implications for the pathophysiology of psychiatric disorders Proceedings of the National Academy of Sciences of the United States of America 2001 98:4066-4071 DOI:10.1073/pnas.071056198 PMID:11274430 PMCID:PMC31180
- Thomas, E. A., Danielson, P. E., Nelson, P. A., Pribyl, T. M., Hilbush, B. S., Hasel, K. W., Sutcliffe, J. G. Clozapine increases apolipoprotein d expression in rodent brain: Towards a mechanism for neuroleptic pharmacotherapy Journal of Neurochemistry 2001 76:789-796 DOI:10.1046/j.1471-4159.2001.00027.x PMID:11158250
- Thomas, E. A., Matli, J. R., Hu, J. L., Carson, M. J., Sutcliffe, J. G. Pertussis toxin treatment prevents 5-ht5a receptor-mediated inhibition of cyclic amp accumulation in rat c6 glioma cells Journal of Neuroscience Research 2000 61:75-81 DOI:10.1002/1097-4547(20000701)61:1<75::aid-jnr9>3.3.co;2-0 PMID:10861802
- Thomas, E. A., Alvarez, C. E., Sutcliffe, J. G. Evolutionarily distinct classes of s27 ribosomal proteins with differential mrna expression in rat hypothalamus Journal of Neurochemistry 2000 74:2259-2267 DOI:10.1046/j.1471-4159.2000.0742259.x PMID:10820185
- Hedlund, P. B., Carson, M. J., Sutcliffe, J. G., Thomas, E. A. Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine(7) receptors Biochemical Pharmacology 1999 58:1807-1813 DOI:10.1016/s0006-2952(99)00274-9 PMID:10571256
- Thomas, E. A., Cravatt, B. F., Sutcliffe, J. G. The endogenous lipid oleamide activates serotonin 5-HT7 neurons in mouse thalamus and hypothalamus Journal of Neurochemistry 1999 72:2370-2378 DOI:10.1046/j.1471-4159.1999.0722370.x PMID:10349846
- Thomas, E. A., Danielson, P. E., Sutcliffe, J. G. RGS9: a regulator of G-protein signalling with specific expression in rat and mouse striatum Journal of Neuroscience Research 1998 52:118-124 DOI:10.1002/(sici)1097-4547(19980401)52:1<118::aid-jnr11>3.0.co;2-6 PMID:9556034
- Thomas, E. A., Carson, M. J., Sutcliffe, J. G. Oleamide-induced modulation of 5-hydroxytryptamine receptor-mediated signaling Annals of the New York Academy of Sciences 1998 861:183-189 PMID:9928256
- Thomas, E. A., Cravatt, B. F., Danielson, P. E., Gilula, N. B., Sutcliffe, J. G. Fatty acid amide hydrolase, the degradative enzyme for anandamide and oleamide, has selective distribution in neurons within the rat central nervous system Journal of Neuroscience Research 1997 50:1047-1052 DOI:10.1002/(sici)1097-4547(19971215)50:6<1047::aid-jnr16>3.0.co;2-1 PMID:9452020
- Thomas, E. A., Carson, M. J., Neal, M. J., Sutcliffe, J. G. Unique allosteric regulation of 5-hydroxytryptamine receptor-mediated signal transduction by oleamide Proceedings of the National Academy of Sciences of the United States of America 1997 94:14115-14119 DOI:10.1073/pnas.94.25.14115 PMID:9391162
- Carson, M. J., Thomas, E. A., Danielson, P. E., Sutcliffe, J. G. The 5-HT(5A) serotonin receptor is expressed predominantly by astrocytes in which it inhibits cAMP accumulation: a mechanism for neuronal suppression of reactive astrocytes Glia 1996 17:317-326 DOI:10.1002/(sici)1098-1136(199608)17:4<317::aid-glia6>3.0.co;2-w PMID:8856328
- Thomas, E. A., Ehlert, F. J. Involvement of the m(2) muscarinic receptor in contractions of the guinea pig trachea, guinea pig esophagus, and rat fundus Biochemical Pharmacology 1996 51:779-788 DOI:10.1016/0006-2952(95)02396-8 PMID:8602873
- Ehlert, F. J., Thomas, E. A. Functional-role of m(2) muscarinic receptors in the guinea-pig ileum Life Sciences 1995 56:965-971 DOI:10.1016/0024-3205(94)00035-q PMID:10188800
- Thomas, E. A., Ehlert, F. J. Pertussis toxin blocks m(2) muscarinic receptor-mediated effects on contraction and cyclic-amp in the guinea-pig ileum, but not m(3)-mediated contractions and phosphoinositide hydrolysis Journal of Pharmacology and Experimental Therapeutics 1994 271:1042-1050 PMID:7965766
- Thomas, E. A., Baker, S. A., Ehlert, F. J. Functional-role of the m(2)-muscarinic receptor in smooth-muscle of guinea-pig ileum Molecular Pharmacology 1993 44:102-110 PMID:8393516
- Griffin, M. T., Thomas, E. A., Ehlert, F. J. Kinetics of activation and in vivo muscarinic receptor binding of N-(2-bromoethyl)-4-piperidinyl diphenylacetate: an analog of 4-DAMP mustard Journal of Pharmacology and Experimental Therapeutics 1993 266:301-305 PMID:8331565
- Thomas, E. A., Hsu, H. H., Griffin, M. T., Hunter, A. L., Luong, T., Ehlert, F. J. Conversion of n-(2-chloroethyl)-4-piperidinyl diphenylacetate (4-damp mustard) to an aziridinium ion and its interaction with muscarinic receptors in various tissues Molecular Pharmacology 1992 41:718-726 PMID:1569923
- Thomas, E. A., Ehlert, F. J. Irreversible effects of 4-DAMP mustard on muscarinic receptors in vivo Proceedings of the Western Pharmacology Society 1992 35:233-237 PMID:1502231
chapter
- Thomas, E. A. Histone posttranslational modifications in schizophrenia Neuroepigenetics. 2017
- Thomas, E. A. The role of histone deacetylase inhibition in the accumulation and stability of disease-related proteins Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. 2016
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