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Thomas, Elizabeth
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Thomas, Elizabeth

Faculty Member
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Positions

  • 2017 - Associate Professor, Neuroscience , Scripps Research
  • 2006 - Honorary Senior Research Fellow, Mental Health Research Institute (Melbourne)
  • 2013 - 2017 Associate Professor, Molecular and Cellular Neuroscience (MCN) , Scripps Research
  • 2009 - 2012 Associate Professor, Molecular Biology , Scripps Research
  • 2002 - 2009 Assistant Professor, Molecular Biology , Scripps Research
  • 1998 - 2002 Senior Research Associate, Molecular Biology , Scripps Research
  • 1995 - 1998 Research Associate, Molecular Biology , Scripps Research
Dr. Elizabeth Thomas investigates the molecular neurobiology of psychiatric and neurodegenerative disorders, such as schizophrenia, bipolar disorder, and Huntington's disease, so that they can be better diagnosed and treated.

Research Areas research areas

  • Mental Illness (UMLS)

Contact

  • bthomas@scripps.edu

Websites

  • Elizabeth A. Thomas, Ph.D.
  • Thomas Laboratory
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Publications

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    • Corey-Bloom, J., Haque, A., Aboufadel, S., Snell, C., Fischer, R. S., Granger, S. W., Granger, D. A., Thomas, E. A. Uric acid as a potential peripheral biomarker for disease features in Huntington's patients Frontiers in Neuroscience  2020 14  DOI:10.3389/fnins.2020.00073  PMID:32194366  PMCID:PMC7065265
    • Gutierrez, A., Corey-Bloom, J., Thomas, E. A., Desplats, P. Evaluation of biochemical and epigenetic measures of peripheral brain-derived neurotrophic factor (BDNF) as a biomarker in Huntington's disease patients Frontiers in Molecular Neuroscience  2020 12  DOI:10.3389/fnmol.2019.00335  PMID:32038165  PMCID:PMC6989488
    • Corey-Bloom, J., Haque, A. S., Park, S., Nathan, A. S., Baker, R. W., Thomas, E. A. Salivary levels of total huntingtin are elevated in Huntington's disease patients Scientific Reports  2018 8  DOI:10.1038/s41598-018-25095-3  PMID:29743609  PMCID:PMC5943337
    • Thomas, E. A., D'Mello, S. R. Complex neuroprotective and neurotoxic effects of histone deacetylases Journal of Neurochemistry  2018 145:96-110  DOI:10.1111/jnc.14309  PMID:29355955  PMCID:PMC5920706
    • Dean, B., Gibbons, A., Gogos, A., Udawela, M., Thomas, E., Scarr, E. Studies on prostaglandin-endoperoxide synthase 1: lower levels in schizophrenia and after treatment with antipsychotic drugs in conjunction with aspirin International Journal of Neuropsychopharmacology  2018 21:216-225  DOI:10.1093/ijnp/pyx092  PMCID:PMC5838806
    • Corey-Bloom, J., Aikin, A. M., Gutierrez, A. M., Nadhem, J. S., Howell, T. L., Thomas, E. A. Beneficial effects of glatiramer acetate in Huntington's disease mouse models: Evidence for BDNF-elevating and immunomodulatory mechanisms Brain Research  2017 1673:102-110  DOI:10.1016/j.brainres.2017.08.013  PMID:28823953  PMCID:PMC5595665
    • Thomas, E. A. Histone posttranslational modifications in schizophrenia Advances in Experimental Medicine and Biology  2017 978:237-254  DOI:10.1007/978-3-319-53889-1_13  PMID:28523550
    • Thomas, E. A. DNA methylation in Huntington's disease: Implications for transgenerational effects Neuroscience Letters  2016 625:34-39  DOI:10.1016/j.neulet.2015.10.060  PMID:26522374  PMCID:PMC4864163
    • Jia, H., Wang, Y., Morris, C. D., Jacques, V., Gottesfeld, J. M., Rusche, J. R., Thomas, E. A. The effects of pharmacological inhibition of histone deacetylase 3 (HDAC3) in Huntington's disease mice PLoS One  2016 11  DOI:10.1371/journal.pone.0152498  PMID:27031333  PMCID:PMC4816519
    • Scarr, E., Udawela, M., Greenough, M. A., Neo, J., Suk Seo, M., Money, T. T., Upadhyay, A., Bush, A. I., Everall, I. P., Thomas, E. A., Dean, B. Increased cortical expression of the zinc transporter SLC39A12 suggests a breakdown in zinc cellular homeostasis as part of the pathophysiology of schizophrenia NPJ Schizophrenia  2016 2  DOI:10.1038/npjschz.2016.2  PMID:27336053  PMCID:PMC4898896
    • Scarr, E., Udawela, M., Thomas, E. A., Dean, B. Changed gene expression in subjects with schizophrenia and low cortical muscarinic M1 receptors predicts disrupted upstream pathways interacting with that receptor Molecular Psychiatry  2016 23:295-303  DOI:10.1038/mp.2016.195  PMID:27801890  PMCID:PMC5794886
    • Jia, H., Morris, C. D., Williams, R. M., Loring, J. F., Thomas, E. A. HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation Proceedings of the National Academy of Sciences of the United States of America  2015 112:E56-E64  DOI:10.1073/pnas.1415195112  PMID:25535382  PMCID:PMC4291662
    • Corey-Bloom, J., Jia, H., Aikin, A. M., Thomas, E. A. Disease modifying potential of glatiramer acetate in Huntington's disease Journal of Huntington's Disease  2014 3:311-316  DOI:10.3233/jhd-140110  PMID:25300334  PMCID:PMC4480978
    • Thomas, E. A. Involvement of HDAC1 and HDAC3 in the pathology of polyglutamine disorders: therapeutic implications for selective HDAC1/HDAC3 inhibitors Pharmaceuticals (Basel)  2014 7:634-661  DOI:10.3390/ph7060634  PMID:24865773  PMCID:PMC4078513
    • Unterwald, E. M., Page, M. E., Brown, T. B., Miller, J. S., Ruiz, M., Pescatore, K. A., Xu, B., Reichardt, L. F., Beverley, J., Tang, B., Steiner, H., Thomas, E. A., et al. Behavioral and transcriptome alterations in male and female mice with postnatal deletion of TrkB in dorsal striatal medium spiny neurons Molecular Neurodegeneration  2013 8:47  DOI:10.1186/1750-1326-8-47  PMID:24369067  PMCID:PMC3880973
    • Tang, B., Jia, H., Kast, R. J., Thomas, E. A. Epigenetic changes at gene promoters in response to immune activation in utero Brain Behavior and Immunity  2013 30:168-175  DOI:10.1016/j.bbi.2013.01.086  PMID:23402795
    • Jia, H. Q., Kast, R. J., Steffan, J. S., Thomas, E. A. Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: Implications for the ubiquitin-proteasomal and autophagy systems Human Molecular Genetics  2012 21:5280-5293  DOI:10.1093/hmg/dds379  PMID:22965876  PMCID:PMC3510756
    • Tang, B., Becanovic, K., Desplats, P. A., Spencer, B., Hill, A. M., Connolly, C., Masliah, E., Leavitt, B. R., Thomas, E. A. Forkhead box protein p1 is a transcriptional repressor of immune signaling in the cns: Implications for transcriptional dysregulation in huntington disease Human Molecular Genetics  2012 21:3097-3111  DOI:10.1093/hmg/dds132  PMID:22492998  PMCID:PMC3384380
    • Keilani, S., Chandwani, S., Dolios, G., Bogush, A., Beck, H., Hatzopoulos, A. K., Rao, G. N., Thomas, E. A., Wang, R., Ehrlich, M. E. Egr-1 induces darpp-32 expression in striatal medium spiny neurons via a conserved intragenic element Journal of Neuroscience  2012 32:6808-6818  DOI:10.1523/jneurosci.5448-11.2012  PMID:22593050
    • Jia, H. Q., Pallos, J., Jacques, V., Lau, A., Tang, B., Cooper, A., Syed, A., Purcell, J., Chen, Y., Sharma, S., Sangrey, G. R., Darnell, S. B., et al. Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of huntington's disease Neurobiology of Disease  2012 46:351-361  DOI:10.1016/j.nbd.2012.01.016  PMID:22590724  PMCID:PMC3528106
    • Tang, B., Capitao, C., Dean, B., Thomas, E. A. Differential age- and disease-related effects on the expression of genes related to the arachidonic acid signaling pathway in schizophrenia Psychiatry Research  2012 196:201-206  DOI:10.1016/j.psychres.2011.09.026  PMID:22397921  PMCID:PMC3361581
    • Thomas, E. A. Transcriptomics of antipsychotic drug function: What have we learned from rodent studies? Current Psychopharmacology  2012 1:272-283
    • Tang, B., Dean, B., Thomas, E. A. Disease- and age-related changes in histone acetylation at gene promoters in psychiatric disorders Translational Psychiatry  2011 1:e64  DOI:10.1038/tp.2011.61  PMID:22832356  PMCID:PMC3305989
    • Tang, B., Di Lena, P., Schaffer, L., Head, S. R., Baldi, P., Thomas, E. A. Genome-wide identification of bcl11b gene targets reveals role in brain-derived neurotrophic factor signaling PLoS One  2011 6:e23691  DOI:10.1371/journal.pone.0023691  PMID:21912641  PMCID:PMC3164671
    • Tang, B., Seredenina, T., Coppola, G., Kuhn, A., Geschwind, D. H., Luthi-Carter, R., Thomas, E. A. Gene expression profiling of r6/2 transgenic mice with different cag repeat lengths reveals genes associated with disease onset and progression in huntington's disease Neurobiology of Disease  2011 42:459-467  DOI:10.1016/j.nbd.2011.02.008  PMID:21334439  PMCID:PMC3079804
    • Sutcliffe, J. G., Hedlund, P. B., Thomas, E. A., Bloom, F. E., Hilbush, B. S. Peripheral reduction of beta-amyloid is sufficient to reduce brain beta-amyloid: Implications for alzheimer's disease Journal of Neuroscience Research  2011 89:808-814  DOI:10.1002/jnr.22603  PMID:21374699
    • Thomas, E. A., Coppola, G., Tang, B., Kuhn, A., Kim, S., Geschwind, D. H., Brown, T. B., Luthi-Carter, R., Ehrlich, M. E. In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons Human Molecular Genetics  2011 20:1049-1060  DOI:10.1093/hmg/ddq548  PMID:21177255  PMCID:PMC3043657
    • Udawela, M., Scarr, E., Hannan, A. J., Thomas, E. A., Dean, B. Phospholipase c beta 1 expression in the dorsolateral prefrontal cortex from patients with schizophrenia at different stages of illness Australian and New Zealand Journal of Psychiatry  2011 45:140-147  DOI:10.3109/00048674.2010.533364  PMID:21091263
    • Narayan, S., Thomas, E. A. Sphingolipid abnormalities in psychiatric disorders: a missing link in pathology? Frontiers in Bioscience  2011 16:1797-1810  DOI:10.2741/3822  PMID:21196265
    • Ku, S., Soragni, E., Campau, E., Thomas, E. A., Altun, G., Laurent, L. C., Loring, J. F., Napierala, M., Gottesfeld, J. M. Friedreich's ataxia induced pluripotent stem cells model intergenerational GAA.TTC triplet repeat instability Cell Stem Cell  2010 7:631-637  DOI:10.1016/j.stem.2010.09.014  PMID:21040903  PMCID:PMC2987635
    • Denny, C. A., Desplats, P. A., Thomas, E. A., Seyfried, T. N. Cerebellar lipid differences between r6/1 transgenic mice and humans with huntington's disease Journal of Neurochemistry  2010 115:748-758  DOI:10.1111/j.1471-4159.2010.06964.x  PMID:20731757
    • Schlosburg, J. E., Blankman, J. L., Long, J. Z., Nomura, D. K., Pan, B., Kinsey, S. G., Nguyen, P. T., Ramesh, D., Booker, L., Burston, J. J., Thomas, E. A., Selley, D. E., et al. Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system Nature Neuroscience  2010 13:1113-1119  DOI:10.1038/nn.2616  PMID:20729846  PMCID:PMC2928870
    • Perdomo, G., Kim, D. H., Zhang, T., Thomas, E. A., Toledo, F. G. S., Slusher, S., Fan, Y., Kelley, D. E., Dong, H. H., Qu, S. A role of apolipoprotein D in triglyceride metabolism Journal of Lipid Research  2010 51:1298-1311  DOI:10.1194/jlr.M001206  PMID:20124557  PMCID:PMC3035493
    • Torkamani, A., Dean, B., Schork, N. J., Thomas, E. A. Coexpression network analysis of neural tissue reveals perturbations in developmental processes in schizophrenia Genome Research  2010 20:403-412  DOI:10.1101/gr.101956.109  PMID:20197298  PMCID:PMC2847743
    • Gibbons, A. S., Thomas, E. A., Scarr, E., Dean, B. Low density lipoprotein receptor-related protein and apolipoprotein E expression is altered in schizophrenia Front Psychiatry  2010 1  DOI:10.3389/fpsyt.2010.00019  PMID:21423430  PMCID:PMC3059617
    • Thomas, E. A. Focal nature of neurological disorders necessitates isotype-selective histone deacetylase (hdac) inhibitors Molecular Neurobiology  2009 40:33-45  DOI:10.1007/s12035-009-8067-y  PMID:19396637
    • Gibbons, A. S., Thomas, E. A., Dean, B. Regional and duration of illness differences in the alteration of ncam-180 mrna expression within the cortex of subjects with schizophrenia Schizophrenia Research  2009 112:65-71  DOI:10.1016/j.schres.2009.04.002  PMID:19411161  PMCID:PMC2722680
    • Tang, B., Chang, W. L., Lanigan, C. M., Dean, B., Sutcliffe, J. G., Thomas, E. A. Normal human aging and early-stage schizophrenia share common molecular profiles Aging Cell  2009 8:339-342  DOI:10.1111/j.1474-9726.2009.00468.x  PMID:19245676  PMCID:PMC2695825
    • Thomas, E. A. Selective HDAC inhibitors: Promising treatment for Huntington's disease Bioforum Europe  2009 13:32-34
    • Narayan, S., Head, S. R., Gilmartin, T. J., Dean, B., Thomas, E. A. Evidence for disruption of sphingolipid metabolism in schizophrenia Journal of Neuroscience Research  2009 87:278-288  DOI:10.1002/jnr.21822  PMID:18683247  PMCID:PMC2606914
    • Narayan, S., Tang, B., Head, S. R., Gilmartin, T. J., Sutcliffe, J. G., Dean, B., Thomas, E. A. Molecular profiles of schizophrenia in the cns at different stages of illness Brain Research  2008 1239:235-248  DOI:10.1016/j.brainres.2008.08.023  PMID:18778695  PMCID:PMC2783475
    • Thomas, E. A., Coppola, G., Desplats, P. A., Tang, B., Soragni, E., Burnett, R., Gao, F. Y., Fitzgerald, K. M., Borok, J. F., Herman, D., Geschwind, D. H., Gottesfeld, J. M. The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice Proceedings of the National Academy of Sciences of the United States of America  2008 105:15564-15569  DOI:10.1073/pnas.0804249105  PMID:18829438  PMCID:PMC2563081
    • Desplats, P. A., Lambert, J. R., Thomas, E. A. Functional roles for the striatal-enriched transcription factor, bcl11b, in the control of striatal gene expression and transcriptional dysregulation in huntington's disease Neurobiology of Disease  2008 31:298-308  DOI:10.1016/j.nbd.2008.05.005  PMID:18595722  PMCID:PMC2569875
    • Dean, B., Digney, A., Sundram, S., Thomas, E., Scarr, E. Plasma apolipoprotein E is decreased in schizophrenia spectrum and bipolar disorder Psychiatry Research  2008 158:75-78  DOI:10.1016/j.psychres.2007.05.008  PMID:18096247
    • Gibbons, A. S., Scarr, E., McOmish, C. E., Hannan, A. J., Thomas, E. A., Dean, B. Regulator of g-protein signalling 4 expression is not altered in the prefrontal cortex in schizophrenia Australian and New Zealand Journal of Psychiatry  2008 42:740-745  PMID:18622782
    • Desplats, P. A., Denny, C. A., Kass, K. E., Gilmartin, T., Head, S. R., Sutcliffe, J. G., Seyffied, T. N., Thomas, E. A. Glycolipid and ganglioside metabolism imbalances in huntington's disease Neurobiology of Disease  2007 27:265-277  DOI:10.1016/j.nbd.2007.05.003  PMID:17600724  PMCID:PMC2082128
    • Dean, B., Keriakous, D., Scarr, E., Thomas, E. A. Gene expression profiling in Brodmann's area 46 from subjects with schizophrenia The Australian and New Zealand Journal of Psychiatry  2007 41:308-320  DOI:10.1080/00048670701213245  PMID:17464717
    • Narayan, S., Kass, K. E., Thomas, E. A. Chronic haloperidol treatment results in a decrease in the expression of myelin/oligodendrocyte-related genes in the mouse brain Journal of Neuroscience Research  2007 85:757-765  DOI:10.1002/jnr.21161  PMID:17177202
    • Thomas, E. A., Yao, J. K. Clozapine specifically alters the arachidonic acid pathway in mice lacking apolipoprotein d Schizophrenia Research  2007 89:147-153  DOI:10.1016/j.schres.2006.08.011  PMID:17011169
    • Thomas, E. A. Striatal specificity of gene expression dysregulation in huntington's disease Journal of Neuroscience Research  2006 84:1151-1164  DOI:10.1002/jnr.21046  PMID:16983659
    • Thomas, E. A. Molecular profiling of antipsychotic drug function: convergent mechanisms in the pathology and treatment of psychiatric disorders Molecular Neurobiology  2006 34:109-128  DOI:10.1385/mn:34:2:109  PMID:17220533
    • Desplats, P. A., Kass, K. E., Gilmartin, T., Stanwood, G. D., Woodward, E. L., Head, S. R., Sutcliffe, J. G., Thomas, E. A. Selective deficits in the expression of striatal-enriched mrnas in huntington's disease Journal of Neurochemistry  2006 96:743-757  DOI:10.1111/j.1471-4159.2005.03588.x  PMID:16405510
    • Ziolkowska, B., Gieryk, A., Bilecki, W., Wawrzczak-Bargiela, A., Wedzony, K., Chocyk, A., Danielson, P. E., Thomas, E. A., Hilbush, B. S., Sutcliffe, J. G., Przewlocki, R. Regulation of alpha-synuclein expression in limbic and motor brain regions of morphine-treated mice Journal of Neuroscience  2005 25:4996-5003  DOI:10.1523/jneurosci.4376-04.2005  PMID:15901780
    • Digney, A., Keriakous, D., Scarr, E., Thomas, E., Dean, B. Differential changes in apolipoprotein E in schizophrenia and bipolar I disorder Biological Psychiatry  2005 57:711-715  DOI:10.1016/j.biopsych.2004.12.028  PMID:15820227
    • Dean, B., Keriakous, D., Thomas, E., Scarr, E. Understanding the pathology of schizophrenia: The impact of high- throughput screening of the genome and proteome in postmortem CNS Current Psychiatry Reviews  2005 1:1-9  DOI:10.2174/1573400052953547
    • Yao, J. K., Thomas, E. A., Reddy, R. D., Keshavan, M. S. Association of plasma apolipoproteins d with rbc membrane arachidonic acid levels in schizophrenia Schizophrenia Research  2005 72:259-266  DOI:10.1016/j.schres.2004.05.007  PMID:15560970
    • Thomas, E. A., George, R. C., Sutcliffe, J. G. Apolipoprotein d modulates arachidonic acid signaling in cultured cells: Implications for psychiatric disorders Prostaglandins Leukotrienes and Essential Fatty Acids  2003 69:421-427  DOI:10.1016/j.plefa.2003.08.014  PMID:14623496
    • Dean, B., Laws, S. M., Hone, E., Taddei, K., Scarr, E., Thomas, E. A., Harper, C., McClean, C., Masters, C., Lautenschlager, N., Gandy, S. E., Martins, R. N. Increased levels of apolipoprotein e in the frontal cortex of subjects with schizophrenia Biological Psychiatry  2003 54:616-622  DOI:10.1016/s0006-3223(03)00075-1  PMID:13129656
    • Thomas, E. A., Copolov, D. L., Sutcliffe, J. G. From pharmacotherapy to pathophysiology: Emerging mechanisms of apolipoprotein d in psychiatric disorders Current Molecular Medicine  2003 3:408-418  DOI:10.2174/1566524033479681  PMID:12942994
    • Thomas, E. A., Laws, S. M., Sutcliffe, J. G., Harper, C., Dean, B., McClean, C., Masters, C., Lautenschlager, N., Gandy, S. E., Martins, R. N. Apolipoprotein d levels are elevated in prefrontal cortex of subjects with alzheimer's disease: No relation to apolipoprotein e expression or genotype Biological Psychiatry  2003 54:136-141  DOI:10.1016/s0006-3223(02)01976-5  PMID:12873803
    • Hedlund, P. B., Danielson, P. E., Thomas, E. A., Slanina, K., Carson, M. J., Sutcliffe, J. G. No hypothermic response to serotonin in 5-ht7 receptor knockout mice Proceedings of the National Academy of Sciences of the United States of America  2003 100:1375-1380  DOI:10.1073/pnas.0337340100  PMID:12529502  PMCID:PMC298780
    • Thomas, E. A., George, R. C., Danielson, P. E., Nelson, P. A., Warren, A. J., Lo, D., Sutcliffe, J. G. Antipsychotic drug treatment alters expression of mrnas encoding lipid metabolism-related proteins Molecular Psychiatry  2003 8:983-993  DOI:10.1038/sj.mp.4001425  PMID:14647396
    • Thomas, E. A., Dean, B., Scarr, E., Copolov, D., Sutcliffe, J. G. Differences in neuroanatomical sites of apod elevation discriminate between schizophrenia and bipolar disorder Molecular Psychiatry  2003 8:167-175  DOI:10.1038/sj.mp.4001223  PMID:12610649
    • Thomas, E. A., Sutcliffe, J. G. The neuirobiology of apolipoproteins in psychiatric disorders Molecular Neurobiology  2002 26:369-388  DOI:10.1385/mn:26:2-3:369  PMID:12428765
    • Alvarez, C. E., Sutcliffe, J. G., Thomas, E. A. Novel isoform of insulin receptor substrate p53/p58 is generated by alternative splicing in the crib/sh3-binding region Journal of Biological Chemistry  2002 277:24728-24734  DOI:10.1074/jbc.M20512200  PMID:12006592
    • Nelson, P. A., Sutcliffe, J. G., Thomas, E. A. A new UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase mRNA exhibits predominant expression in the hypothalamus, thalamus and amygdala of mouse forebrain Brain Research. Gene Expression Patterns  2002 1:95-99  PMID:15018805
    • Thomas, E. A., Sautkulis, L. N., Criado, J. R., Games, D., Sutcliffe, J. G. Apolipoprotein d mrna expression is elevated in pdapp transgenic mice Journal of Neurochemistry  2001 79:1059-1064  DOI:10.1046/j.1471-4159.2001.00654.x  PMID:11739619
    • Thomas, E. A., Foye, P. E., Alvarez, C. E., Usui, H., Sutcliffe, J. G. Insulin receptor substrate protein p53 localization in rats suggests mechanism for specific polyglutamine neurodegeneration Neuroscience Letters  2001 309:145-148  DOI:10.1016/s0304-3940(01)02064-x  PMID:11514062
    • Thomas, E. A., Dean, B., Pavey, G., Sutcliffe, J. G. Increased cns levels of apolipoprotein d in schizophrenic and bipolar subjects: Implications for the pathophysiology of psychiatric disorders Proceedings of the National Academy of Sciences of the United States of America  2001 98:4066-4071  DOI:10.1073/pnas.071056198  PMID:11274430  PMCID:PMC31180
    • Thomas, E. A., Danielson, P. E., Nelson, P. A., Pribyl, T. M., Hilbush, B. S., Hasel, K. W., Sutcliffe, J. G. Clozapine increases apolipoprotein d expression in rodent brain: Towards a mechanism for neuroleptic pharmacotherapy Journal of Neurochemistry  2001 76:789-796  DOI:10.1046/j.1471-4159.2001.00027.x  PMID:11158250
    • Thomas, E. A., Matli, J. R., Hu, J. L., Carson, M. J., Sutcliffe, J. G. Pertussis toxin treatment prevents 5-ht5a receptor-mediated inhibition of cyclic amp accumulation in rat c6 glioma cells Journal of Neuroscience Research  2000 61:75-81  DOI:10.1002/1097-4547(20000701)61:1<75::aid-jnr9>3.3.co;2-0  PMID:10861802
    • Thomas, E. A., Alvarez, C. E., Sutcliffe, J. G. Evolutionarily distinct classes of s27 ribosomal proteins with differential mrna expression in rat hypothalamus Journal of Neurochemistry  2000 74:2259-2267  DOI:10.1046/j.1471-4159.2000.0742259.x  PMID:10820185
    • Hedlund, P. B., Carson, M. J., Sutcliffe, J. G., Thomas, E. A. Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine(7) receptors Biochemical Pharmacology  1999 58:1807-1813  DOI:10.1016/s0006-2952(99)00274-9  PMID:10571256
    • Thomas, E. A., Cravatt, B. F., Sutcliffe, J. G. The endogenous lipid oleamide activates serotonin 5-HT7 neurons in mouse thalamus and hypothalamus Journal of Neurochemistry  1999 72:2370-2378  DOI:10.1046/j.1471-4159.1999.0722370.x  PMID:10349846
    • Thomas, E. A., Danielson, P. E., Sutcliffe, J. G. RGS9: a regulator of G-protein signalling with specific expression in rat and mouse striatum Journal of Neuroscience Research  1998 52:118-124  DOI:10.1002/(sici)1097-4547(19980401)52:1<118::aid-jnr11>3.0.co;2-6  PMID:9556034
    • Thomas, E. A., Carson, M. J., Sutcliffe, J. G. Oleamide-induced modulation of 5-hydroxytryptamine receptor-mediated signaling Annals of the New York Academy of Sciences  1998 861:183-189  PMID:9928256
    • Thomas, E. A., Cravatt, B. F., Danielson, P. E., Gilula, N. B., Sutcliffe, J. G. Fatty acid amide hydrolase, the degradative enzyme for anandamide and oleamide, has selective distribution in neurons within the rat central nervous system Journal of Neuroscience Research  1997 50:1047-1052  DOI:10.1002/(sici)1097-4547(19971215)50:6<1047::aid-jnr16>3.0.co;2-1  PMID:9452020
    • Thomas, E. A., Carson, M. J., Neal, M. J., Sutcliffe, J. G. Unique allosteric regulation of 5-hydroxytryptamine receptor-mediated signal transduction by oleamide Proceedings of the National Academy of Sciences of the United States of America  1997 94:14115-14119  DOI:10.1073/pnas.94.25.14115  PMID:9391162
    • Carson, M. J., Thomas, E. A., Danielson, P. E., Sutcliffe, J. G. The 5-HT(5A) serotonin receptor is expressed predominantly by astrocytes in which it inhibits cAMP accumulation: a mechanism for neuronal suppression of reactive astrocytes Glia  1996 17:317-326  DOI:10.1002/(sici)1098-1136(199608)17:4<317::aid-glia6>3.0.co;2-w  PMID:8856328
    • Thomas, E. A., Ehlert, F. J. Involvement of the m(2) muscarinic receptor in contractions of the guinea pig trachea, guinea pig esophagus, and rat fundus Biochemical Pharmacology  1996 51:779-788  DOI:10.1016/0006-2952(95)02396-8  PMID:8602873
    • Ehlert, F. J., Thomas, E. A. Functional-role of m(2) muscarinic receptors in the guinea-pig ileum Life Sciences  1995 56:965-971  DOI:10.1016/0024-3205(94)00035-q  PMID:10188800
    • Thomas, E. A., Ehlert, F. J. Pertussis toxin blocks m(2) muscarinic receptor-mediated effects on contraction and cyclic-amp in the guinea-pig ileum, but not m(3)-mediated contractions and phosphoinositide hydrolysis Journal of Pharmacology and Experimental Therapeutics  1994 271:1042-1050  PMID:7965766
    • Thomas, E. A., Baker, S. A., Ehlert, F. J. Functional-role of the m(2)-muscarinic receptor in smooth-muscle of guinea-pig ileum Molecular Pharmacology  1993 44:102-110  PMID:8393516
    • Griffin, M. T., Thomas, E. A., Ehlert, F. J. Kinetics of activation and in vivo muscarinic receptor binding of N-(2-bromoethyl)-4-piperidinyl diphenylacetate: an analog of 4-DAMP mustard Journal of Pharmacology and Experimental Therapeutics  1993 266:301-305  PMID:8331565
    • Thomas, E. A., Hsu, H. H., Griffin, M. T., Hunter, A. L., Luong, T., Ehlert, F. J. Conversion of n-(2-chloroethyl)-4-piperidinyl diphenylacetate (4-damp mustard) to an aziridinium ion and its interaction with muscarinic receptors in various tissues Molecular Pharmacology  1992 41:718-726  PMID:1569923
    • Thomas, E. A., Ehlert, F. J. Irreversible effects of 4-DAMP mustard on muscarinic receptors in vivo Proceedings of the Western Pharmacology Society  1992 35:233-237  PMID:1502231
  • chapter

    • Thomas, E. A. Histone posttranslational modifications in schizophrenia Neuroepigenetics. 2017
    • Thomas, E. A. The role of histone deacetylase inhibition in the accumulation and stability of disease-related proteins Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. 2016
    • Dean, B., Gibbons, A., Scarr, E., Thomas, E. A. Changes in gene expression in subjects with schizophrenia associated with disease progression Handbook of Schizophrenia Spectrum Disorders. 237-251. 2011  DOI:10.1007/978-94-007-0837-2_10
    • Thomas, E. A. Apolipoprotein D and arachidonic acid interactions in the treatment and pathology of schizophrenia Fatty Acids & Oxidative Stress in Neuropsychiatric Disorders. 203-221. 2007
    • Thomas, E. A., Sutcliffe, J. G. The role of apolipoprotein D in the mechanism of action of clozapine and in schizophrenia Phospholipid Spectrum Disorder in Psychiatry. 2003
    • Ehlert, F. J., Thomas, E. A., Gerstin, E. H., Griffin, M. T. Muscarinic receptors and gastrointestinal smooth muscle Muscarinic Receptor Subtypes in Smooth Muscle. 89-102. 1996
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Research

research overview

  • Molecular Mechanisms of Human CNS Disorders

    Work in our laboratory is directed towards identifying genes associated with human neurological disorders and pharmacotherapies associated with these disorders using high-throughput gene expression methodologies. Two main areas of research focus on Huntington's disease (HD) and schizophrenia. In our HD studies, we are focusing on a subset of genes that exhibit restricted expression in the striatum, the region of the brain most affected in HD. Furthermore, we are investigating how the mutated huntingtin protein causes specific neurodegeneration of the striatum, by identifying which striatum-enriched proteins interact with the huntingtin protein, the protein product of the Huntington gene. We are also studying genes that are abnormally expressed in human post-mortem samples from subjects with schizophrenia throughout the course of illness. We have identified dramatically different gene expression profiles of subjects in early versus late stages of illness and are further characterizing pathways associated with these different stages. The goals of these studies are to achieve a better understanding of dysfunctional systems in CNS disorders and to provide a basis for new therapeutic approaches and disease prevention.
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Background

education and training

  • Ph.D. in Pharmacology, University of California, Irvine 1990 - 1994
  • B.S. in Biology, University of California, Berkeley 1985 - 1989
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Contact

full name

  • Elizabeth Anne Thomas

geographic location

  • Scripps California 

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