recent publications
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academic article
- He, L., Seitz, S. P., Trainor, G. L., Tortolani, D., Vaccaro, W., Poss, M., Tarby, C. M., Tokarski, J. S., Penhallow, B., Hung, C. Y., Attar, R., Lin, T. A. Modulation of cofilin phosphorylation by inhibition of the Lim family kinases Bioorganic & Medicinal Chemistry Letters 2012 22:5995-5998 DOI:10.1016/j.bmcl.2012.07.002 PMID:22902653
- Williams, D. K., Chen, X. T., Tarby, C., Kaltenbach, R., Cai, Z. W., Tokarski, J. S., An, Y., Sack, J. S., Wautlet, B., Gullo-Brown, J., Henley, B. J., Jeyaseelan, R., et al. Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors Bioorganic & Medicinal Chemistry Letters 2010 20:2998-3002 DOI:10.1016/j.bmcl.2010.01.042 PMID:20382527
- McDonnell, P. A., Yanchunas, J., Newitt, J. A., Tao, L., Kiefer, S. E., Ortega, M., Kut, S., Burford, N., Goldfarb, V., Duke, G. J., Shen, H., Metzler, W., et al. Assessing compound binding to the Eg5 motor domain using a thermal shift assay Analytical Biochemistry 2009 392:59-69 DOI:10.1016/j.ab.2009.05.044 PMID:19497292
- Moree, W. J., Kataoka, K. I., Ramirez-Weinhouse, M. M., Shiota, T., Imai, M., Tsutsumi, T., Sudo, M., Endo, N., Muroga, Y., Hada, T., Fanning, D., Saunders, J., et al. Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series Bioorganic & Medicinal Chemistry Letters 2008 18:1869-1873 DOI:10.1016/j.bmcl.2008.02.015 PMID:18313297
- Littke, A., Soumeillant, M., Kaltenbach, R. F., Cherney, R. J., Tarby, C. M., Kiau, S. Mild and general methods for the palladium-catalyzed cyanation of aryl and heteroaryl chlorides Organic Letters 2007 9:1711-1714 DOI:10.1021/ol070372d PMID:17385875
- Tarby, C. M., Kaltenbach, R. F., Huynh, T., Pudzianowski, A., Shen, H., Ortega-Nanos, M., Sheriff, S., Newitt, J. A., McDonnell, P. A., Burford, N., Fairchild, C. R., Vaccaro, W., et al. Inhibitors of human mitotic kinesin Eg5: Characterization of the 4-phenyl-tetrahydrolsoquinoline lead series Bioorganic & Medicinal Chemistry Letters 2006 16:2095-2100 DOI:10.1016/j.bmcl.2006.01.056 PMID:16458511
- Moree, W. J., Kataoka, K., Ramirez-Weinhouse, M. M., Shiota, T., Imai, M., Sudo, M., Tsutsumi, T., Endo, N., Muroga, Y., Hada, T., Tanaka, H., Morita, T., et al. Small molecule antagonists of the CCR2b receptor. Part 2: Discovery process and initial structure-activity relationships of diamine derivatives Bioorganic & Medicinal Chemistry Letters 2004 14:5413-5416 DOI:10.1016/j.bmcl.2004.08.009 PMID:15454236
- Imai, N., Shiota, T., Kataoka, K., Tarby, C. M., Moree, W. J., Tsutsumi, T., Sudo, M., Ramirez-Weinhouse, M. M., Comer, D., Sun, C. M., Yamagami, S., Tanaka, H., et al. Small molecule inhibitors of the CCR2b receptor. Part 1: Discovery and optimization of homopiperazine derivatives Bioorganic & Medicinal Chemistry Letters 2004 14:5407-5411 DOI:10.1016/j.bmcl.2004.08.008 PMID:15454235
- Tarby, C. M. Recent advances in the development of next generation non-nucleoside reverse transcriptase inhibitors Current Topics in Medicinal Chemistry 2004 4:1045-1057 DOI:10.2174/1568026043388295 PMID:15193138
- Zhou, J., Termin, A., Wayland, M., Tarby, C. M. Solid-phase synthesis of potential aspartic acid protease inhibitors containing a hydroxyethylamine isostere Tetrahedron Letters 1999 40:2729-2732 DOI:10.1016/S0040-4039(99)00351-2
- Saunders, J., Tarby, C. M. Opportunities for novel therapeutic agents acting at chemokine receptors Drug Discovery Today 1999 4:80-92 DOI:10.1016/S1359-6446(98)01280-X PMID:10234160
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Boger, D. L., Han, N. H., Tarby, C. M., Boyce, C. W., Cai, H., Jin, Q., Kitos, P. A.
Synthesis, chemical properties, and preliminary evaluation of substituted CBI analogs of CC-1065 and the duocarmycins incorporating the 7-cyano-1,2,9,9a-tetrahydrocyclopropa c benz e indol-4-one alkylation subunit: Hammett quantitation of the magnitude of electronic effects on functional reactivity
Journal of Organic Chemistry
1996
61:4894-4912
DOI:10.1021/jo9605298
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Cheng, S., Tarby, C. M., Comer, D. D., Williams, J. P., Caporale, L. H., Myers, P. L., Boger, D. L.
A solution-phase strategy for the synthesis of chemical libraries containing small organic molecules: a universal and dipeptide mimetic template
Bioorganic & Medicinal Chemistry
1996
4:727-737
DOI:10.1016/0968-0896(96)00069-7
PMID:8804539
- Bondy, S., Cheng, S., Saunders, J., Tarby, C., Wheeler, K. Molecular diversity and solid-phase synthesis Drug Discovery Today 1996 1:132-133 DOI:10.1016/1359-6446(96)89060-x
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Boger, D. L., McKie, J. A., Han, N. H., Tarby, C. M., Riggs, H. Q. W., Kitos, P. A.
A Hammett correlation for CC-1065 and duocarmycin analogs: magnitude of substituent electronic effects on functional reactivity
Bioorganic & Medicinal Chemistry Letters
1996
6:659-664
DOI:10.1016/0960-894x(96)00093-5
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Boger, D. L.*, Tarby, C. M.*, Myers, P. L., Caporale, L. H.
Generalized dipeptidomimetic template: solution phase parallel synthesis of combinatorial libraries
Journal of the American Chemical Society
1996
118:2109-2110
DOI:10.1021/ja9539711
(* = equal contribution)
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Boger, D. L., Mesini, P., Tarby, C. M.
Chemical and structural comparison of N-BOC-CBQ and N-BOC-CBI - identification and structural origin of an unappreciated but productive stability of the CC-1065 and duocarmycin SA alkylation subunits
Journal of the American Chemical Society
1994
116:6461-6462
DOI:10.1021/ja00093a067
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Boger, D. L.*, Johnson, D. S.*, Yun, W., Tarby, C. M.
Molecular basis for sequence selective DNA alkylation by (+)- and ent-(-)-CC-1065 and related agents: alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity
Bioorganic & Medicinal Chemistry
1994
2:115-135
DOI:10.1016/S0968-0896(00)82007-6
PMID:7922122
(* = equal contribution)
- deStevens, G., Eager, M., Tarby, C. Steric and electronic effects controlling the synthesis of bridgehead nitrogen heterocycles Heterocycles 1993 35:763-773 DOI:10.3987/COM-92-S(T)50