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Tarby, Christine
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Tarby, Christine

Graduate Student
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Positions

  • 2001 - Principal Research Scientist, Bristol-Myers Squibb

Websites

  • Doctoral Dissertation
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Publications

recent publications
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  • Publications without PubMed PMIDs

  • academic article

    • He, L., Seitz, S. P., Trainor, G. L., Tortolani, D., Vaccaro, W., Poss, M., Tarby, C. M., Tokarski, J. S., Penhallow, B., Hung, C. Y., Attar, R., Lin, T. A. Modulation of cofilin phosphorylation by inhibition of the Lim family kinases Bioorganic & Medicinal Chemistry Letters  2012 22:5995-5998  DOI:10.1016/j.bmcl.2012.07.002  PMID:22902653
    • Williams, D. K., Chen, X. T., Tarby, C., Kaltenbach, R., Cai, Z. W., Tokarski, J. S., An, Y., Sack, J. S., Wautlet, B., Gullo-Brown, J., Henley, B. J., Jeyaseelan, R., et al. Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors Bioorganic & Medicinal Chemistry Letters  2010 20:2998-3002  DOI:10.1016/j.bmcl.2010.01.042  PMID:20382527
    • McDonnell, P. A., Yanchunas, J., Newitt, J. A., Tao, L., Kiefer, S. E., Ortega, M., Kut, S., Burford, N., Goldfarb, V., Duke, G. J., Shen, H., Metzler, W., et al. Assessing compound binding to the Eg5 motor domain using a thermal shift assay Analytical Biochemistry  2009 392:59-69  DOI:10.1016/j.ab.2009.05.044  PMID:19497292
    • Moree, W. J., Kataoka, K. I., Ramirez-Weinhouse, M. M., Shiota, T., Imai, M., Tsutsumi, T., Sudo, M., Endo, N., Muroga, Y., Hada, T., Fanning, D., Saunders, J., et al. Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series Bioorganic & Medicinal Chemistry Letters  2008 18:1869-1873  DOI:10.1016/j.bmcl.2008.02.015  PMID:18313297
    • Littke, A., Soumeillant, M., Kaltenbach, R. F., Cherney, R. J., Tarby, C. M., Kiau, S. Mild and general methods for the palladium-catalyzed cyanation of aryl and heteroaryl chlorides Organic Letters  2007 9:1711-1714  DOI:10.1021/ol070372d  PMID:17385875
    • Tarby, C. M., Kaltenbach, R. F., Huynh, T., Pudzianowski, A., Shen, H., Ortega-Nanos, M., Sheriff, S., Newitt, J. A., McDonnell, P. A., Burford, N., Fairchild, C. R., Vaccaro, W., et al. Inhibitors of human mitotic kinesin Eg5: Characterization of the 4-phenyl-tetrahydrolsoquinoline lead series Bioorganic & Medicinal Chemistry Letters  2006 16:2095-2100  DOI:10.1016/j.bmcl.2006.01.056  PMID:16458511
    • Moree, W. J., Kataoka, K., Ramirez-Weinhouse, M. M., Shiota, T., Imai, M., Sudo, M., Tsutsumi, T., Endo, N., Muroga, Y., Hada, T., Tanaka, H., Morita, T., et al. Small molecule antagonists of the CCR2b receptor. Part 2: Discovery process and initial structure-activity relationships of diamine derivatives Bioorganic & Medicinal Chemistry Letters  2004 14:5413-5416  DOI:10.1016/j.bmcl.2004.08.009  PMID:15454236
    • Imai, N., Shiota, T., Kataoka, K., Tarby, C. M., Moree, W. J., Tsutsumi, T., Sudo, M., Ramirez-Weinhouse, M. M., Comer, D., Sun, C. M., Yamagami, S., Tanaka, H., et al. Small molecule inhibitors of the CCR2b receptor. Part 1: Discovery and optimization of homopiperazine derivatives Bioorganic & Medicinal Chemistry Letters  2004 14:5407-5411  DOI:10.1016/j.bmcl.2004.08.008  PMID:15454235
    • Tarby, C. M. Recent advances in the development of next generation non-nucleoside reverse transcriptase inhibitors Current Topics in Medicinal Chemistry  2004 4:1045-1057  DOI:10.2174/1568026043388295  PMID:15193138
    • Zhou, J., Termin, A., Wayland, M., Tarby, C. M. Solid-phase synthesis of potential aspartic acid protease inhibitors containing a hydroxyethylamine isostere Tetrahedron Letters  1999 40:2729-2732  DOI:10.1016/S0040-4039(99)00351-2
    • Saunders, J., Tarby, C. M. Opportunities for novel therapeutic agents acting at chemokine receptors Drug Discovery Today  1999 4:80-92  DOI:10.1016/S1359-6446(98)01280-X  PMID:10234160
    • degree-related publication Boger, D. L., Han, N. H., Tarby, C. M., Boyce, C. W., Cai, H., Jin, Q., Kitos, P. A. Synthesis, chemical properties, and preliminary evaluation of substituted CBI analogs of CC-1065 and the duocarmycins incorporating the 7-cyano-1,2,9,9a-tetrahydrocyclopropa c benz e indol-4-one alkylation subunit: Hammett quantitation of the magnitude of electronic effects on functional reactivity Journal of Organic Chemistry  1996 61:4894-4912  DOI:10.1021/jo9605298
    • degree-related publication Cheng, S., Tarby, C. M., Comer, D. D., Williams, J. P., Caporale, L. H., Myers, P. L., Boger, D. L. A solution-phase strategy for the synthesis of chemical libraries containing small organic molecules: a universal and dipeptide mimetic template Bioorganic & Medicinal Chemistry  1996 4:727-737  DOI:10.1016/0968-0896(96)00069-7  PMID:8804539
    • Bondy, S., Cheng, S., Saunders, J., Tarby, C., Wheeler, K. Molecular diversity and solid-phase synthesis Drug Discovery Today  1996 1:132-133  DOI:10.1016/1359-6446(96)89060-x
    • degree-related publication Boger, D. L., McKie, J. A., Han, N. H., Tarby, C. M., Riggs, H. Q. W., Kitos, P. A. A Hammett correlation for CC-1065 and duocarmycin analogs: magnitude of substituent electronic effects on functional reactivity Bioorganic & Medicinal Chemistry Letters  1996 6:659-664  DOI:10.1016/0960-894x(96)00093-5
    • degree-related publication Boger, D. L.*, Tarby, C. M.*, Myers, P. L., Caporale, L. H. Generalized dipeptidomimetic template: solution phase parallel synthesis of combinatorial libraries Journal of the American Chemical Society  1996 118:2109-2110  DOI:10.1021/ja9539711 (* = equal contribution)
    • degree-related publication Boger, D. L., Mesini, P., Tarby, C. M. Chemical and structural comparison of N-BOC-CBQ and N-BOC-CBI - identification and structural origin of an unappreciated but productive stability of the CC-1065 and duocarmycin SA alkylation subunits Journal of the American Chemical Society  1994 116:6461-6462  DOI:10.1021/ja00093a067
    • degree-related publication Boger, D. L.*, Johnson, D. S.*, Yun, W., Tarby, C. M. Molecular basis for sequence selective DNA alkylation by (+)- and ent-(-)-CC-1065 and related agents: alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity Bioorganic & Medicinal Chemistry  1994 2:115-135  DOI:10.1016/S0968-0896(00)82007-6  PMID:7922122 (* = equal contribution)
    • deStevens, G., Eager, M., Tarby, C. Steric and electronic effects controlling the synthesis of bridgehead nitrogen heterocycles Heterocycles  1993 35:763-773  DOI:10.3987/COM-92-S(T)50
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Background

education and training

  • Ph.D. in Chemistry, Scripps Research 1993 - 1996
  • B.A. in Chemistry, Drew University , cum laude and with special honors in chemistry 1985 - 1989

advisee of

  • graduate advising relationship

    • Boger, Dale, Ph.D.  candidacy, 1994 - 1996
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Contact

full name

  • Christine Mary Tarby

geographic location

  • Scripps California 

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