recent publications
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academic article
- Sharma, M., Rajendrarao, S., Shahani, N., Ramirez-Jarquin, U. N., Subramaniam, S. Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease Proceedings of the National Academy of Sciences of the United States of America 2020 117:15989-15999 DOI:10.1073/pnas.2002144117 PMID:32581130 PMCID:PMC7354937
- Subramaniam, S. Rhes tunnels: A radical new way of communication in the brain's striatum? Bioessays 2020 DOI:10.1002/bies.201900231 PMID:32236969
- Subramaniam, S. Exaggerated mitophagy: a weapon of striatal destruction in the brain? Biochemical Society Transactions 2020 48:709-717 DOI:10.1042/bst20191283 PMID:32129826 PMCID:PMC7200642
- Eshraghi, M., Ramirez-Jarquin, U. N., Shahani, N., Nuzzo, T., De Rosa, A., Swarnkar, S., Galli, N., Rivera, O., Tsaprailis, G., Scharager-Tapia, C., Crynen, G., Li, Q., et al. RasGRP1 is a causal factor in the development of L-DOPA-induced dyskinesia in Parkinson's disease Science Advances 2020 6 DOI:10.1126/sciadv.aaz7001 PMID:32426479 PMCID:PMC7195186
- Ramirez-Jarquin, U. N., Shahani, N., Pryor, W., Usiello, A., Subramaniam, S. The mammalian target of rapamycin (mTOR) kinase mediates haloperidol-induced cataleptic behavior Translational Psychiatry 2020 10 DOI:10.1038/s41398-020-01014-x PMID:33009372 PMCID:PMC7532208
- Subramaniam, S. Selective neuronal death in neurodegenerative diseases: the ongoing mystery Yale Journal of Biology and Medicine 2019 92:695-705 PMID:31866784
- Sharma, M., Jarquin, U. N. R., Rivera, O., Kazantzis, M., Eshraghi, M., Shahani, N., Sharma, V., Tapia, R., Subramaniam, S. Rhes, a striatal-enriched protein, promotes mitophagy via Nix Proceedings of the National Academy of Sciences of the United States of America 2019 116:23760-23771 DOI:10.1073/pnas.1912868116 PMID:31676548 PMCID:PMC6876193
- Shahani, N., Huang, W. C., Varnum, M., Page, D., Subramaniam, S. Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice Neurobiology of Aging 2017 50:134-143 DOI:10.1016/j.neurobiolaging.2016.11.006 PMID:27960107 PMCID:PMC5209246
- Shahani, N., Swarnkar, S., Giovinazzo, V., Morgenweck, J., Bohn, L. M., Scharager-Tapia, C., Pascal, B., Martinez-Acedo, P., Khare, K., Subramaniam, S. RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum Science Signaling 2016 9 DOI:10.1126/scisignal.aaf6670 PMID:27902448 PMCID:PMC5142824
- Swarnkar, S., Chen, Y., Pryor, W. M., Shahani, N., Page, D. T., Subramaniam, S. Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease Neurobiology of Disease 2015 82:66-77 DOI:10.1016/j.nbd.2015.05.011 PMID:26048156
- Shahani, N., Seshadri, S., Jaaro-Peled, H., Ishizuka, K., Hirota-Tsuyada, Y., Wang, Q., Koga, M., Sedlak, T. W., Korth, C., Brandon, N. J., Kamiya, A., Subramaniam, S., et al. DISC1 regulates trafficking and processing of APP and Aβ generation Molecular Psychiatry 2015 20:874-879 DOI:10.1038/mp.2014.100 PMID:25224257 PMCID:PMC4362789
- Tyagi, R., Shahani, N., Gorgen, L., Ferretti, M., Pryor, W., Chen, P. Y., Swarnkar, S., Worley, P. F., Karbstein, K., Snyder, S. H., Subramaniam, S. Rheb inhibits protein synthesis by activating the PERK-eIF2 alpha signaling cascade Cell Reports 2015 10:684-693 DOI:10.1016/j.celrep.2015.01.014 PMID:25660019 PMCID:PMC4524804
- Pryor, W. M., Biagioli, M., Shahani, N., Swarnkar, S., Huang, W. C., Page, D. T., MacDonald, M. E., Subramaniam, S. Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease Science Signaling 2014 7 DOI:10.1126/scisignal.2005633 PMID:25351248
- Narayanan, K. L., Subramaniam, S., Bengston, C. P., Irmady, K., Unsicker, K., von Bohlen und Halbach, O. Role of transient receptor potential channel 1 (TRPC1) in glutamate-induced cell death in the hippocampal cell line HT22 Journal of Molecular Neuroscience 2014 52:425-433 DOI:10.1007/s12031-013-0171-9 PMID:24242951
- Shahani, N., Pryor, W., Swarnkar, S., Kholodilov, N., Thinakaran, G., Burke, R. E., Subramaniam, S. Rheb GTPase regulates beta-secretase levels and amyloid beta generation Journal of Biological Chemistry 2014 289:5799-5808 DOI:10.1074/jbc.M113.532713 PMID:24368770 PMCID:PMC3937651
- Mealer, R. G., Murray, A. J., Shahani, N., Subramaniam, S., Snyder, S. H. Rhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy Journal of Biological Chemistry 2014 289:3547-3554 DOI:10.1074/jbc.M113.536912 PMID:24324270 PMCID:PMC3916556
- Mealer, R. G., Subramaniam, S., Snyder, S. H. Rhes deletion is neuroprotective in the 3-nitropropionic acid model of Huntington's disease Journal of Neuroscience 2013 33:4206-4210 DOI:10.1523/jneurosci.3730-12.2013 PMID:23447628 PMCID:PMC3667505
- Subramaniam, S., Napolitano, F., Mealer, R. G., Kim, S., Errico, F., Barrow, R., Shahani, N., Tyagi, R., Snyder, S. H., Usiello, A. Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia Nature Neuroscience 2012 15:191-193 DOI:10.1038/nn.2994 PMID:22179112 PMCID:PMC3267880
- Subramaniam, S., Snyder, S. H. Huntington's disease is a disorder of the corpus striatum: focus on Rhes (Ras homologue enriched in the striatum) Neuropharmacology 2011 60:1187-1192 DOI:10.1016/j.neuropharm.2010.10.025 PMID:21044641
- Subramaniam, S., Mealer, R. G., Sixt, K. M., Barrow, R. K., Usiello, A., Snyder, S. H. Rhes, a physiologic regulator of sumoylation, enhances cross-sumoylation between the basic sumoylation enzymes E1 and Ubc9 Journal of Biological Chemistry 2010 285:20428-20432 DOI:10.1074/jbc.C110.127191 PMID:20424159 PMCID:PMC2898300
- Subramaniam, S., Unsicker, K. ERK and cell death: ERK1/2 in neuronal death FEBS Journal 2010 277:22-29 DOI:10.1111/j.1742-4658.2009.07367.x PMID:19843173
- Subramaniam, S., Sixt, K. M., Barrow, R., Snyder, S. H. Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity Science 2009 324:1327-1330 DOI:10.1126/science.1172871 PMID:19498170 PMCID:PMC2745286
- Alavian, K. N., Sgado, P., Alberi, L., Subramaniam, S., Simon, H. H. Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression Neural Development 2009 4:11 DOI:10.1186/1749-8104-4-11 PMID:19291307 PMCID:PMC2667502
- Narayanan, K. L., Irmady, K., Subramaniam, S., Unsicker, K., von Bohlen und Halbach, O. Evidence that TRPC1 is involved in hippocampal glutamate-induced cell death Neuroscience Letters 2008 446:117-122 DOI:10.1016/j.neulet.2008.09.034 PMID:18822346
- Subramaniam, S., Strelau, J., Unsicker, K. GDNF prevents TGF-beta-induced damage of the plasma membrane in cerebellar granule neurons by suppressing activation of p38-MAPK via the phosphatidylinositol 3-kinase pathway Cell and Tissue Research 2008 331:373-383 DOI:10.1007/s00441-007-0538-8 PMID:18071753
- Shahani, N., Subramaniam, S., Brandt, R. Purification of MINUS: A negative regulator of microtubule nucleation in a variety of organisms International Journal of Biological Macromolecules 2006 39:15-22 DOI:10.1016/j.ijbiomac.2005.12.014 PMID:16420961
- Shahani, N., Subramaniam, S., Wolf, T., Tackenberg, C., Brandt, R. Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices Journal of Neuroscience 2006 26:6103-6114 DOI:10.1523/jneurosci.4245-05.2006 PMID:16738255
- Subramaniam, S., Unsicker, K. Extracellular signal-regulated kinase as an inducer of non-apoptotic neuronal death Neuroscience 2006 138:1055-1065 DOI:10.1016/j.neuroscience.2005.12.013 PMID:16442236
- Subramaniam, S., Shahani, N., Strelau, J., Laliberte, C., Brandt, R., Kaplan, D., Unsicker, K. Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the phosphatidylinositol 3-kinase/protein kinase A/c-Raf pathway Journal of Neuroscience 2005 25:2838-2852 DOI:10.1523/jneurosci.5060-04.2005 PMID:15772344
- Subramaniam, S., Zirrgiebel, U., von Bohlen und Halbach, O., Strelau, J., Laliberte, C., Kaplan, D. R., Unsicker, K. ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3 Journal of Cell Biology 2004 165:357-369 DOI:10.1083/jcb.200403028 PMID:15123736 PMCID:PMC2172179
- Scholzke, M. N., Potrovita, I., Subramaniam, S., Prinz, S., Schwaninger, M. Glutamate activates NF-kappa B through calpain in neurons European Journal of Neuroscience 2003 18:3305-3310 DOI:10.1046/j.1460-9568.2003.03079.x PMID:14686903
- Subramaniam, S., Strelau, J., Unsicker, K. Growth differentiation factor-15 prevents low potassium-induced cell death of cerebellar granule neurons by differential regulation of Akt and ERK pathways Journal of Biological Chemistry 2003 278:8904-8912 DOI:10.1074/jbc.M210037200 PMID:12514175
- Schuster, N., Bender, H., Philippi, A., Subramaniam, S., Strelau, J., Wang, Z., Krieglstein, K. TGF-beta induces cell death in the oligodendroglial cell line OLI-neu Glia 2002 40:95-108 DOI:10.1002/glia.10110 PMID:12237847
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thesis