Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options
Subramaniam, Srinivasa
Display my h-index
Publications in VIVO
 
    Export Publications Table
co-author
Co-author Network
map of science
Map of Science
Biosketch in .docx format  Create Biosketch

Subramaniam, Srinivasa

Faculty Member
share the uri qr icon Close

Positions

  • 2016 - Associate Professor, Neuroscience , Scripps Research
  • 2012 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2012 - 2016 Assistant Professor, Neuroscience , Scripps Research
  • 2011 - 2012 Research Associate, Department of Neuroscience, School of Medicine, Johns Hopkins University
  • 2006 - 2011 Postdoctoral Fellow, Department of Neuroscience, School of Medicine, Johns Hopkins University

Research Areas research areas

  • Alzheimer (UMLS)

Contact

  • ssubrama@scripps.edu

Websites

  • Srinivasa Subramaniam, Ph.D.
  • Laboratory Website
  • Publications
  • Teaching
  • Background
  • Contact
  • View All
scroll to property group menus

Publications

recent publications
  • All Publications
  • PubMed Display for Export
  • Publications without PubMed PMIDs

  • academic article

    • Eshraghi, M., Karunadharma, P. P., Blin, J., Shahani, N., Ricci, E. P., Michel, A., Urban, N. T., Galli, N., Sharma, M., Ramirez-Jarquin, U. N., Florescu, K., Hernandez, J., et al. Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease Nature Communications  2021 12  DOI:10.1038/s41467-021-21637-y  PMID:33674575  PMCID:PMC7935949
    • Heikkinen, T., Bragge, T., Kuosmanen, J., Parkkari, T., Gustafsson, S., Kwan, M., Beltran, J., Ghavami, A., Subramaniam, S., Shahani, N., Ramirez-Jarquin, U. N., Park, L., et al. Global Rhes knockout in the Q175 Huntington's disease mouse model Plos One  2021 16  DOI:10.1371/journal.pone.0258486  PMID:34648564  PMCID:PMC8516231
    • Ramirez-Jarquin, U. N., Shahani, N., Pryor, W., Usiello, A., Subramaniam, S. The mammalian target of rapamycin (mTOR) kinase mediates haloperidol-induced cataleptic behavior Translational Psychiatry  2020 10  DOI:10.1038/s41398-020-01014-x  PMID:33009372  PMCID:PMC7532208
    • Sharma, M., Rajendrarao, S., Shahani, N., Ramirez-Jarquin, U. N., Subramaniam, S. Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease Proceedings of the National Academy of Sciences of the United States of America  2020 117:15989-15999  DOI:10.1073/pnas.2002144117  PMID:32581130  PMCID:PMC7354937
    • Subramaniam, S. Rhes tunnels: A radical new way of communication in the brain's striatum? Bioessays  2020  DOI:10.1002/bies.201900231  PMID:32236969
    • Subramaniam, S. Exaggerated mitophagy: a weapon of striatal destruction in the brain? Biochemical Society Transactions  2020 48:709-717  DOI:10.1042/bst20191283  PMID:32129826  PMCID:PMC7200642
    • Eshraghi, M., Ramirez-Jarquin, U. N., Shahani, N., Nuzzo, T., De Rosa, A., Swarnkar, S., Galli, N., Rivera, O., Tsaprailis, G., Scharager-Tapia, C., Crynen, G., Li, Q., et al. RasGRP1 is a causal factor in the development of L-DOPA-induced dyskinesia in Parkinson's disease Science Advances  2020 6  DOI:10.1126/sciadv.aaz7001  PMID:32426479  PMCID:PMC7195186
    • Subramaniam, S. Selective neuronal death in neurodegenerative diseases: the ongoing mystery Yale Journal of Biology and Medicine  2019 92:695-705  PMID:31866784
    • Sharma, M., Jarquin, U. N. R., Rivera, O., Kazantzis, M., Eshraghi, M., Shahani, N., Sharma, V., Tapia, R., Subramaniam, S. Rhes, a striatal-enriched protein, promotes mitophagy via Nix Proceedings of the National Academy of Sciences of the United States of America  2019 116:23760-23771  DOI:10.1073/pnas.1912868116  PMID:31676548  PMCID:PMC6876193
    • Shahani, N., Huang, W. C., Varnum, M., Page, D., Subramaniam, S. Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice Neurobiology of Aging  2017 50:134-143  DOI:10.1016/j.neurobiolaging.2016.11.006  PMID:27960107  PMCID:PMC5209246
    • Shahani, N., Swarnkar, S., Giovinazzo, V., Morgenweck, J., Bohn, L. M., Scharager-Tapia, C., Pascal, B., Martinez-Acedo, P., Khare, K., Subramaniam, S. RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum Science Signaling  2016 9  DOI:10.1126/scisignal.aaf6670  PMID:27902448  PMCID:PMC5142824
    • Swarnkar, S., Chen, Y., Pryor, W. M., Shahani, N., Page, D. T., Subramaniam, S. Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease Neurobiology of Disease  2015 82:66-77  DOI:10.1016/j.nbd.2015.05.011  PMID:26048156
    • Shahani, N., Seshadri, S., Jaaro-Peled, H., Ishizuka, K., Hirota-Tsuyada, Y., Wang, Q., Koga, M., Sedlak, T. W., Korth, C., Brandon, N. J., Kamiya, A., Subramaniam, S., et al. DISC1 regulates trafficking and processing of APP and Aβ generation Molecular Psychiatry  2015 20:874-879  DOI:10.1038/mp.2014.100  PMID:25224257  PMCID:PMC4362789
    • Tyagi, R., Shahani, N., Gorgen, L., Ferretti, M., Pryor, W., Chen, P. Y., Swarnkar, S., Worley, P. F., Karbstein, K., Snyder, S. H., Subramaniam, S. Rheb inhibits protein synthesis by activating the PERK-eIF2 alpha signaling cascade Cell Reports  2015 10:684-693  DOI:10.1016/j.celrep.2015.01.014  PMID:25660019  PMCID:PMC4524804
    • Pryor, W. M., Biagioli, M., Shahani, N., Swarnkar, S., Huang, W. C., Page, D. T., MacDonald, M. E., Subramaniam, S. Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease Science Signaling  2014 7  DOI:10.1126/scisignal.2005633  PMID:25351248
    • Narayanan, K. L., Subramaniam, S., Bengston, C. P., Irmady, K., Unsicker, K., von Bohlen und Halbach, O. Role of transient receptor potential channel 1 (TRPC1) in glutamate-induced cell death in the hippocampal cell line HT22 Journal of Molecular Neuroscience  2014 52:425-433  DOI:10.1007/s12031-013-0171-9  PMID:24242951
    • Shahani, N., Pryor, W., Swarnkar, S., Kholodilov, N., Thinakaran, G., Burke, R. E., Subramaniam, S. Rheb GTPase regulates beta-secretase levels and amyloid beta generation Journal of Biological Chemistry  2014 289:5799-5808  DOI:10.1074/jbc.M113.532713  PMID:24368770  PMCID:PMC3937651
    • Mealer, R. G., Murray, A. J., Shahani, N., Subramaniam, S., Snyder, S. H. Rhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy Journal of Biological Chemistry  2014 289:3547-3554  DOI:10.1074/jbc.M113.536912  PMID:24324270  PMCID:PMC3916556
    • Mealer, R. G., Subramaniam, S., Snyder, S. H. Rhes deletion is neuroprotective in the 3-nitropropionic acid model of Huntington's disease Journal of Neuroscience  2013 33:4206-4210  DOI:10.1523/jneurosci.3730-12.2013  PMID:23447628  PMCID:PMC3667505
    • Subramaniam, S., Napolitano, F., Mealer, R. G., Kim, S., Errico, F., Barrow, R., Shahani, N., Tyagi, R., Snyder, S. H., Usiello, A. Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia Nature Neuroscience  2012 15:191-193  DOI:10.1038/nn.2994  PMID:22179112  PMCID:PMC3267880
    • Subramaniam, S., Snyder, S. H. Huntington's disease is a disorder of the corpus striatum: focus on Rhes (Ras homologue enriched in the striatum) Neuropharmacology  2011 60:1187-1192  DOI:10.1016/j.neuropharm.2010.10.025  PMID:21044641
    • Subramaniam, S., Mealer, R. G., Sixt, K. M., Barrow, R. K., Usiello, A., Snyder, S. H. Rhes, a physiologic regulator of sumoylation, enhances cross-sumoylation between the basic sumoylation enzymes E1 and Ubc9 Journal of Biological Chemistry  2010 285:20428-20432  DOI:10.1074/jbc.C110.127191  PMID:20424159  PMCID:PMC2898300
    • Subramaniam, S., Unsicker, K. ERK and cell death: ERK1/2 in neuronal death FEBS Journal  2010 277:22-29  DOI:10.1111/j.1742-4658.2009.07367.x  PMID:19843173
    • Subramaniam, S., Sixt, K. M., Barrow, R., Snyder, S. H. Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity Science  2009 324:1327-1330  DOI:10.1126/science.1172871  PMID:19498170  PMCID:PMC2745286
    • Alavian, K. N., Sgado, P., Alberi, L., Subramaniam, S., Simon, H. H. Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression Neural Development  2009 4:11  DOI:10.1186/1749-8104-4-11  PMID:19291307  PMCID:PMC2667502
    • Narayanan, K. L., Irmady, K., Subramaniam, S., Unsicker, K., von Bohlen und Halbach, O. Evidence that TRPC1 is involved in hippocampal glutamate-induced cell death Neuroscience Letters  2008 446:117-122  DOI:10.1016/j.neulet.2008.09.034  PMID:18822346
    • Subramaniam, S., Strelau, J., Unsicker, K. GDNF prevents TGF-beta-induced damage of the plasma membrane in cerebellar granule neurons by suppressing activation of p38-MAPK via the phosphatidylinositol 3-kinase pathway Cell and Tissue Research  2008 331:373-383  DOI:10.1007/s00441-007-0538-8  PMID:18071753
    • Shahani, N., Subramaniam, S., Brandt, R. Purification of MINUS: A negative regulator of microtubule nucleation in a variety of organisms International Journal of Biological Macromolecules  2006 39:15-22  DOI:10.1016/j.ijbiomac.2005.12.014  PMID:16420961
    • Shahani, N., Subramaniam, S., Wolf, T., Tackenberg, C., Brandt, R. Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices Journal of Neuroscience  2006 26:6103-6114  DOI:10.1523/jneurosci.4245-05.2006  PMID:16738255
    • Subramaniam, S., Unsicker, K. Extracellular signal-regulated kinase as an inducer of non-apoptotic neuronal death Neuroscience  2006 138:1055-1065  DOI:10.1016/j.neuroscience.2005.12.013  PMID:16442236
    • Subramaniam, S., Shahani, N., Strelau, J., Laliberte, C., Brandt, R., Kaplan, D., Unsicker, K. Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the phosphatidylinositol 3-kinase/protein kinase A/c-Raf pathway Journal of Neuroscience  2005 25:2838-2852  DOI:10.1523/jneurosci.5060-04.2005  PMID:15772344
    • Subramaniam, S., Zirrgiebel, U., von Bohlen und Halbach, O., Strelau, J., Laliberte, C., Kaplan, D. R., Unsicker, K. ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3 Journal of Cell Biology  2004 165:357-369  DOI:10.1083/jcb.200403028  PMID:15123736  PMCID:PMC2172179
    • Scholzke, M. N., Potrovita, I., Subramaniam, S., Prinz, S., Schwaninger, M. Glutamate activates NF-kappa B through calpain in neurons European Journal of Neuroscience  2003 18:3305-3310  DOI:10.1046/j.1460-9568.2003.03079.x  PMID:14686903
    • Subramaniam, S., Strelau, J., Unsicker, K. Growth differentiation factor-15 prevents low potassium-induced cell death of cerebellar granule neurons by differential regulation of Akt and ERK pathways Journal of Biological Chemistry  2003 278:8904-8912  DOI:10.1074/jbc.M210037200  PMID:12514175
    • Schuster, N., Bender, H., Philippi, A., Subramaniam, S., Strelau, J., Wang, Z., Krieglstein, K. TGF-beta induces cell death in the oligodendroglial cell line OLI-neu Glia  2002 40:95-108  DOI:10.1002/glia.10110  PMID:12237847
  • thesis

    • Regulators of cerebellar granule neuron degeneration 2004

featured in

  • Scripps Florida Scientists Find Regulator of Amyloid Plaque Buildup in Alzheimer’s Disease  News Release
scroll to property group menus

Teaching

advisees

  • graduate advising relationship

    • Subramaniam, Srinivasa (Faculty Member) advising Park, Sophia 2016 -
scroll to property group menus

Background

education and training

  • Ph.D., Heidelberg University , Interdisciplinary Center for Neuroscience, with Dr. Klaus Unsicker 2001 - 2004
  • M.Sc. in Biochemistry, Bangalore University , Central College 1994 - 1996
  • B.Sc. in Chemistry, Botany, Zoology, Bangalore University , National College 1989 - 1992
scroll to property group menus

Contact

full name

  • Srinivasa Subramaniam

geographic location

  • Scripps Florida 

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support