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Shabat, Doron
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Shabat, Doron

Faculty Member Adjunct
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Positions

  • 2016 - Professor Adjunct, Chemistry , Scripps Research

Contact

  • chdoron@scripps.edu

Websites

  • Doron Shabat, Ph.D.
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Publications

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    • Rader, C., Segal, D. J., Shabat, D. Carlos F. Barbas III (1964-2014): Visionary at the interface of chemistry and biology ACS Chemical Biology  2014 9:1645-1646  DOI:10.1021/cb5005993  PMID:25123302
    • Zhou, Q. H., Ruffoni, A., Gianatassio, R., Fujiwara, Y., Sella, E., Shabat, D., Baran, P. S. Direct synthesis of fluorinated heteroarylether bioisosteres Angewandte Chemie-International Edition  2013 52:3949-3952  DOI:10.1002/anie.201300763  PMID:23460402  PMCID:PMC3643141
    • Sella, E., Weinstain, R., Erez, R., Burns, N. Z., Baran, P. S., Shabat, D. Sulfhydryl-based dendritic chain reaction Chemical Communications  2010 46:6575-6577  DOI:10.1039/c0cc02195d  PMID:20714571
    • Weinstain, R., Baran, P. S., Shabat, D. Activity-linked labeling of enzymes by self-immolative polymers Bioconjugate Chemistry  2009 20:1783-1791  DOI:10.1021/bc9002037  PMID:19689155
    • Perry-Feigenbaum, R., Baran, P. S., Shabat, D. The pyridinone-methide elimination Organic & Biomolecular Chemistry  2009 7:4825-4828  DOI:10.1039/b915265b  PMID:19907770
    • Shamis, M., Barbas, C. F., Shabat, D. A new visual screening assay for catalytic antibodies with retro-aldol retro-michael activity Bioorganic & Medicinal Chemistry Letters  2007 17:1172-1175  DOI:10.1016/j.bmcl.2006.12.057  PMID:17234408
    • Weinstain, R., Lerner, R. A., Barbas, C. F., Shabat, D. Antibody-catalyzed asymmetric intramolecular michael addition of aldehydes and ketones to yield the disfavored cis-product Journal of the American Chemical Society  2005 127:13104-13105  DOI:10.1021/ja0536825  PMID:16173712
    • Amir, R. J., Popkov, M., Lerner, R. A., Barbas, C. E., Shabat, D. Prodrug activation gated by a molecular "or" logic trigger Angewandte Chemie-International Edition  2005 44:4378-4381  DOI:10.1002/anie.200500842  PMID:15942963
    • Haba, K., Popkov, M., Shamis, M., Lerner, R. A., Barbas, C. F., Shabat, D. Single-triggered trimeric prodrugs Angewandte Chemie-International Edition  2005 44:716-720  DOI:10.1002/anie.200461657  PMID:15657968
    • Gopin, A., Rader, C., Shabat, D. New chemical adaptor unit designed to release a drug from a tumor targeting device by enzymatic triggering Bioorganic & Medicinal Chemistry  2004 12:1853-1858  DOI:10.1016/j.bmc.2004.01.41  PMID:15051054
    • Rader, C., Turner, J. M., Heine, A., Shabat, D., Sinha, S. C., Wilson, I. A., Lerner, R. A., Barbas, C. F. A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy Journal of Molecular Biology  2003 332:889-899  DOI:10.1016/s0022-2836(03)00992-6  PMID:12972259
    • Schroeder, U., Bernt, K. M., Lange, B., Wenkel, J., Jikai, J., Shabat, D., Amir, R., Huebener, N., Niethammer, A. G., Hagemeier, C., Wiebusch, L., Gaedicke, G., et al. Hydrolytically activated etoposide prodrugs inhibit mdr-1 function and eradicate established mr-1 multidrug-resistant t-cell leukemia Blood  2003 102:246-253  DOI:10.1182/blood-2002-07-2268  PMID:12623853
    • Shabat, D., Lode, H. N., Pertl, U., Reisfeld, R. A., Rader, C., Lerner, R. A., Barbas, C. F. In vivo activity in a catalytic antibody-prodrug system: antibody catalyzed etoposide prodrug activation for selective chemotherapy Proceedings of the National Academy of Sciences of the United States of America  2001 98:7528-7533  DOI:10.1073/pnas.131187998  PMID:11404472  PMCID:PMC34702
    • List, B., Shabat, D., Zhong, G. F., Turner, J. M., Bui, T., Anderson, J., Lerner, R. A., Barbas, C. F., Li, A. A catalytic enantioselective route to hydroxy-substituted quaternary carbon centers: Resolution of tertiary aldols with a catalytic antibody Journal of the American Chemical Society  1999 121:7283-7291  DOI:10.1021/ja991507g
    • Shulman, A., Keinan, E., Shabat, D., Barbas, C. F. Teaching catalytic antibodies to undergraduate students - an organic chemistry lab experiment Journal of Chemical Education  1999 76:977-982
    • Shabat, D., Rader, C., List, B., Lerner, R. A., Barbas, C. F. Multiple event activation of a generic prodrug trigger by antibody catalysis Proceedings of the National Academy of Sciences of the United States of America  1999 96:6925-6930  DOI:10.1073/pnas.96.12.6925  PMID:10359815
    • Shabat, D., List, B., Lerner, R. A., Barbas, C. F. A short enantioselective synthesis of 1-deoxy-l-xylulose by antibody catalysis Tetrahedron Letters  1999 40:1437-1440  DOI:10.1016/s0040-4039(98)02699-9
    • Shabat, D., Shulman, H., Itzhaky, H., Reymond, J. L., Keinan, E. Enantioselectivity vs. Kinetic resolution in antibody catalysis: Formation of the (s) product despite preferential binding of the (r) intermediate Chemical Communications  1998 1759-1760  DOI:10.1039/a802374c
    • List, B., Shabat, D., Barbas, C. F., Lerner, R. A. Enantioselective total synthesis of some brevicomins using aldolase antibody 38c2 Chemistry-a European Journal  1998 4:881-885  DOI:10.1002/(sici)1521-3765(19980515)4:5<881::aid-chem881>3.0.co;2-#
    • Hoffmann, T., Zhong, G. F., List, B., Shabat, D., Anderson, J., Gramatikova, S., Lerner, R. A., Barbas, C. F. Aldolase antibodies of remarkable scope Journal of the American Chemical Society  1998 120:2768-2779  DOI:10.1021/ja973676b
    • Zhong, G. F., Shabat, D., List, B., Anderson, J., Sinha, S. C., Lerner, R. A., Barbas, C. F. Catalytic enantioselective retro-aldol reactions: Kinetic resolution of β-hydroxyketones with aldolase antibodies Angewandte Chemie-International Edition  1998 37:2481-2484  DOI:10.1002/(sici)1521-3773(19981002)37:18<2481::aid-anie2481>3.0.co;2-t
    • Shabat, D., Grynszpan, F., Saphier, S., Turniansky, A., Avnir, D., Keinan, E. An efficient sol-gel reactor for antibody-catalyzed transformations Chemistry of Materials  1997 9:2258-2260  DOI:10.1021/cm970193y
    • Keinan, E., Sinha, S. C., Shabat, D., Itzhaky, H., Reymond, J. L. Asymmetric organic synthesis with catalytic antibodies Acta Chemica Scandinavica  1996 50:679-687  DOI:10.3891/acta.chem.scand.50-0679  PMID:8756356
    • Ghosh, P., Shabat, D., Kumar, S., Sinha, S. C., Grynszpan, F., Li, J., Noodleman, L., Keinan, E. Using antibodies to perturb the coordination sphere of a transition metal complex Nature  1996 382:339-341  DOI:10.1038/382339a0  PMID:8684461
    • Shabat, D., Sinha, S. C., Reymond, J. L., Keinan, E. Catalytic antibodies as probes of evolution: Modeling of a primordial glycosidase Angewandte Chemie-International Edition  1996 35:2628-2630  DOI:10.1002/anie.199626281
    • Shabat, D., Itzhaky, H., Reymond, J. L., Keinan, E. Antibody catalysis of a reaction otherwise strongly disfavoured in water Nature  1995 374:143-146  DOI:10.1038/374143a0  PMID:7877686
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Contact

full name

  • Doron Yacov Shabat, Ph.D.

geographic location

  • Scripps California 

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