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Rodriguez, Rodrigo

Graduate Student

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  • Wang, X., Gao, Y., Ma, Z., Rodriguez, R. A., Yu, Z. X., Chen, C. Syntheses of sceptrins and nakamuric acid and insights into the biosyntheses of pyrrole-imidazole dimers Organic Chemistry Frontiers  2015 2:978-984  DOI:10.1039/c5qo00165j  PMID:26328059  PMCID:PMC4551504
  • Ma, Z., Wang, X., Wang, X., Rodriguez, R. A., Moore, C. E., Gao, S., Tan, X., Ma, Y., Rheingold, A. L., Baran, P. S., Chen, C. Response to Comment on "Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence" Science  2015 349:149  DOI:10.1126/science.aaa9626  PMID:26160939  PMCID:PMC4536548
  • Ma, Z., Wang, X., Wang, X., Rodriguez, R. A., Moore, C. E., Gao, S., Tan, X., Ma, Y., Rheingold, A. L., Baran, P. S., Chen, C. Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence Science  2014 346:219-224  DOI:10.1126/science.1255677  PMID:25301624  PMCID:PMC4205478
  • Rodriguez, R. A., Steed, D. B., Kawamata, Y., Su, S., Smith, P. A., Steed, T. C., Romesberg, F. E., Baran, P. S. Axinellamines as broad-spectrum antibacterial agents: scalable synthesis and biology Journal of the American Chemical Society  2014 136:15403-15413  DOI:10.1021/ja508632y  PMID:25328977  PMCID:PMC4227811
  • Rodriguez, R. A., Pan, C. M., Yabe, Y., Kawamata, Y., Eastgate, M. D., Baran, P. S. Palau'chlor: a practical and reactive chlorinating reagent Journal of the American Chemical Society  2014 136:6908-6911  DOI:10.1021/ja5031744  PMID:24758725  PMCID:PMC4333596
  • Fujiwara, Y., Dixon, J. A., O'Hara, F., Funder, E. D., Dixon, D. D., Rodriguez, R. A., Baxter, R. D., Herle, B., Sach, N., Collins, M. R., Ishihara, Y., Baran, P. S. Practical and innate carbon-hydrogen functionalization of heterocycles Nature  2012 492:95-99  DOI:10.1038/nature11680  PMID:23201691  PMCID:PMC3518649
  • Fujiwara, Y., Dixon, J. A., Rodriguez, R. A., Baxter, R. D., Dixon, D. D., Collins, M. R., Blackmond, D. G., Baran, P. S. A new reagent for direct difluoromethylation Journal of the American Chemical Society  2012 134:1494-1497  DOI:10.1021/ja211422g  PMID:22229949  PMCID:PMC3269891
  • Seiple, I. B., Su, S., Young, I. S., Nakamura, A., Yamaguchi, J., Jorgensen, L., Rodriguez, R. A., O'Malley, D. P., Gaich, T., Kock, M., Baran, P. S. Enantioselective total syntheses of (-)-palau'amine, (-)-axinellamines, and (-)-massadines Journal of the American Chemical Society  2011 133:14710-14726  DOI:10.1021/ja2047232  PMID:21861522  PMCID:PMC3173569
  • Su, S., Rodriguez, R. A., Baran, P. S. Scalable, stereocontrolled total syntheses of (±)-axinellamines A and B Journal of the American Chemical Society  2011 133:13922-13925  DOI:10.1021/ja206191g  PMID:21846138  PMCID:PMC3164937
  • Vasko, R. C., Rodriguez, R. A., Cunningham, C. N., Ardi, V. C., Agard, D. A., McAlpine, S. R. Mechanistic studies of Sansalvamide A-amide: an allosteric modulator of Hsp90 ACS Medicinal Chemistry Letters  2010 1:4-8  DOI:10.1021/ml900003f  PMID:20730035  PMCID:PMC2922868
  • Seiple, I. B., Su, S., Rodriguez, R. A., Gianatassio, R., Fujiwara, Y., Sobel, A. L., Baran, P. S. Direct C-H arylation of electron-deficient heterocycles with arylboronic acids Journal of the American Chemical Society  2010 132:13194-13196  DOI:10.1021/ja1066459  PMID:20812741  PMCID:PMC2946225
  • Rodriguez, R. A., Pan, P. S., Vasko, R. C., Pan, C. M., Disman, W. S., McAlpine, S. R. Structure-activity of Sansalvamide A derivatives and their apoptotic activity in the pancreatic cancer cell line PL-45 Journal of the Mexican Chemical Society  2008 52:201-211
  • Davis, M. R., Styers, T. J., Rodriguez, R. A., Pan, P. S., Vasko, R. C., McAlpine, S. R. Synthesis and cytotoxicity of a new class of potent decapeptide macrocycles Organic Letters  2008 10:177-180  DOI:10.1021/ol702403r  PMID:18095697
  • Rodriguez, R. A., Pan, P. S., Pan, C. M., Ravula, S., Lapera, S., Singh, E. K., Styers, T. J., Brown, J. D., Cajica, J., Parry, E., Otrubova, K., McAlpine, S. R. Synthesis of second-generation Sansalvamide A derivatives: novel templates as potential antitumor agents Journal of Organic Chemistry  2007 72:1980-2002  DOI:10.1021/jo061830j  PMID:17315929
  • Styers, T. J., Rodriguez, R., Pan, P. S., McAlpine, S. R. High-yielding macrocyclization conditions used in the synthesis of novel Sansalvamide A derivatives Tetrahedron Letters  2006 47:515-517  DOI:10.1016/j.tetlet.2005.11.056
  • Otrubova, K., Styers, T. J., Pan, P. S., Rodriguez, R., McGuire, K. L., McAlpine, S. R. Synthesis and novel structure-activity relationships of potent sansalvamide A derivatives Chemical Communications  2006 1033-1034  DOI:10.1039/b517434a  PMID:16491200
  • Styers, T. J., Kekec, A., Rodriguez, R., Brown, J. D., Cajica, J., Pan, P. S., Parry, E., Carroll, C. L., Medina, I., Corral, R., Lapera, S., Otrubova, K., et al. Synthesis of Sansalvamide A derivatives and their cytotoxicity in the MSS colon cancer cell line HT-29 Bioorganic & Medicinal Chemistry  2006 14:5625-5631  DOI:10.1016/j.bmc.2006.04.031  PMID:16697205

Background

education and training

• Ph.D. in Chemistry, Scripps Research 2008 - 2014
• B.S. in Chemistry, San Diego State University 2008

advisee of

• graduate advising relationship

  • Boger, Dale, Ph.D.  candidacy, 2009 - 2014

Contact

full name

• Rodrigo A Rodriguez

geographic location

• Scripps California