recent publications
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academic article
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Ma, Z., Wang, X., Wang, X., Rodriguez, R. A., Moore, C. E., Gao, S., Tan, X., Ma, Y., Rheingold, A. L., Baran, P. S., Chen, C. Response to Comment on "Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence" Science 2015 349:149 DOI:10.1126/science.aaa9626 PMID:26160939 PMCID:PMC4536548
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Wang, X., Gao, Y., Ma, Z., Rodriguez, R. A., Yu, Z. X., Chen, C. Syntheses of sceptrins and nakamuric acid and insights into the biosyntheses of pyrrole-imidazole dimers Organic Chemistry Frontiers 2015 2:978-984 DOI:10.1039/c5qo00165j PMID:26328059 PMCID:PMC4551504
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Rodriguez, R. A., Steed, D. B., Kawamata, Y., Su, S., Smith, P. A., Steed, T. C., Romesberg, F. E., Baran, P. S. Axinellamines as broad-spectrum antibacterial agents: scalable synthesis and biology Journal of the American Chemical Society 2014 136:15403-15413 DOI:10.1021/ja508632y PMID:25328977 PMCID:PMC4227811
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Ma, Z., Wang, X., Wang, X., Rodriguez, R. A., Moore, C. E., Gao, S., Tan, X., Ma, Y., Rheingold, A. L., Baran, P. S., Chen, C. Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence Science 2014 346:219-224 DOI:10.1126/science.1255677 PMID:25301624 PMCID:PMC4205478
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Rodriguez, R. A., Pan, C. M., Yabe, Y., Kawamata, Y., Eastgate, M. D., Baran, P. S. Palau'chlor: a practical and reactive chlorinating reagent Journal of the American Chemical Society 2014 136:6908-6911 DOI:10.1021/ja5031744 PMID:24758725 PMCID:PMC4333596
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Fujiwara, Y., Dixon, J. A., O'Hara, F., Funder, E. D., Dixon, D. D., Rodriguez, R. A., Baxter, R. D., Herle, B., Sach, N., Collins, M. R., Ishihara, Y., Baran, P. S. Practical and innate carbon-hydrogen functionalization of heterocycles Nature 2012 492:95-99 DOI:10.1038/nature11680 PMID:23201691 PMCID:PMC3518649
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Fujiwara, Y., Dixon, J. A., Rodriguez, R. A., Baxter, R. D., Dixon, D. D., Collins, M. R., Blackmond, D. G., Baran, P. S. A new reagent for direct difluoromethylation Journal of the American Chemical Society 2012 134:1494-1497 DOI:10.1021/ja211422g PMID:22229949 PMCID:PMC3269891
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Seiple, I. B., Su, S., Young, I. S., Nakamura, A., Yamaguchi, J., Jorgensen, L., Rodriguez, R. A., O'Malley, D. P., Gaich, T., Kock, M., Baran, P. S. Enantioselective total syntheses of (-)-palau'amine, (-)-axinellamines, and (-)-massadines Journal of the American Chemical Society 2011 133:14710-14726 DOI:10.1021/ja2047232 PMID:21861522 PMCID:PMC3173569
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Su, S., Rodriguez, R. A., Baran, P. S. Scalable, stereocontrolled total syntheses of (±)-axinellamines A and B Journal of the American Chemical Society 2011 133:13922-13925 DOI:10.1021/ja206191g PMID:21846138 PMCID:PMC3164937
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Seiple, I. B., Su, S., Rodriguez, R. A., Gianatassio, R., Fujiwara, Y., Sobel, A. L., Baran, P. S. Direct C-H arylation of electron-deficient heterocycles with arylboronic acids Journal of the American Chemical Society 2010 132:13194-13196 DOI:10.1021/ja1066459 PMID:20812741 PMCID:PMC2946225
- Vasko, R. C., Rodriguez, R. A., Cunningham, C. N., Ardi, V. C., Agard, D. A., McAlpine, S. R. Mechanistic studies of Sansalvamide A-amide: an allosteric modulator of Hsp90 ACS Medicinal Chemistry Letters 2010 1:4-8 DOI:10.1021/ml900003f PMID:20730035 PMCID:PMC2922868
- Rodriguez, R. A., Pan, P. S., Vasko, R. C., Pan, C. M., Disman, W. S., McAlpine, S. R. Structure-activity of Sansalvamide A derivatives and their apoptotic activity in the pancreatic cancer cell line PL-45 Journal of the Mexican Chemical Society 2008 52:201-211
- Davis, M. R., Styers, T. J., Rodriguez, R. A., Pan, P. S., Vasko, R. C., McAlpine, S. R. Synthesis and cytotoxicity of a new class of potent decapeptide macrocycles Organic Letters 2008 10:177-180 DOI:10.1021/ol702403r PMID:18095697
- Rodriguez, R. A., Pan, P. S., Pan, C. M., Ravula, S., Lapera, S., Singh, E. K., Styers, T. J., Brown, J. D., Cajica, J., Parry, E., Otrubova, K., McAlpine, S. R. Synthesis of second-generation Sansalvamide A derivatives: novel templates as potential antitumor agents Journal of Organic Chemistry 2007 72:1980-2002 DOI:10.1021/jo061830j PMID:17315929
- Styers, T. J., Kekec, A., Rodriguez, R., Brown, J. D., Cajica, J., Pan, P. S., Parry, E., Carroll, C. L., Medina, I., Corral, R., Lapera, S., Otrubova, K., et al. Synthesis of Sansalvamide A derivatives and their cytotoxicity in the MSS colon cancer cell line HT-29 Bioorganic & Medicinal Chemistry 2006 14:5625-5631 DOI:10.1016/j.bmc.2006.04.031 PMID:16697205
- Styers, T. J., Rodriguez, R., Pan, P. S., McAlpine, S. R. High-yielding macrocyclization conditions used in the synthesis of novel Sansalvamide A derivatives Tetrahedron Letters 2006 47:515-517 DOI:10.1016/j.tetlet.2005.11.056
- Otrubova, K., Styers, T. J., Pan, P. S., Rodriguez, R., McGuire, K. L., McAlpine, S. R. Synthesis and novel structure-activity relationships of potent sansalvamide A derivatives Chemical Communications 2006 1033-1034 DOI:10.1039/b517434a PMID:16491200
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