recent publications
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academic article
- Guerrero, M., Urbano, M., Kim, E. K., Gamo, A. M., Riley, S., Abgaryan, L., Leaf, N., Van Orden, L. J., Brown, S. J., Xie, J. Y., Porreca, F., Cameron, M. D., et al. Design and synthesis of a novel and selective kappa opioid receptor (KOR) antagonist (BTRX-335140) Journal of Medicinal Chemistry 2019 62:1761-1780 DOI:10.1021/acs.jmedchem.8b01679 PMID:30707578 PMCID:PMC6395531
- Xie, J. Y., De Felice, M., Kopruszinski, C. M., Eyde, N., LaVigne, J., Remeniuk, B., Hernandez, P., Yue, X., Goshima, N., Ossipov, M., King, T., Streicher, J. M., et al. Kappa opioid receptor antagonists: A possible new class of therapeutics for migraine prevention Cephalalgia 2017 37:780-794 DOI:10.1177/0333102417702120 PMID:28376659
- Harris, R. A., Bajo, M., Bell, R. L., Blednov, Y. A., Varodayan, F. P., Truitt, J. M., de Guglielmo, G., Lasek, A. W., Logrip, M. L., Vendruscolo, L. F. Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents Journal of Neuroscience 2017 37:1139-1155 DOI:10.1523/jneurosci.2002-16.2016 PMID:27986929 PMCID:PMC5296793
- Burkert, K., Zellmann, T., Meier, R., Kaiser, A., Stichel, J., Meiler, J., Mittapalli, G. K., Roberts, E., Beck-Sickinger, A. G. A deep hydrophobic binding cavity is the main interaction for different Y2R antagonists ChemMedChem 2017 12:75-85 DOI:10.1002/cmdc.201600433 PMID:27874262
- Scott, F. L., Clemons, B., Brooks, J., Brahmachary, E., Powell, R., Dedman, H., Desale, H. G., Timony, G. A., Martinborough, E., Rosen, H., Roberts, E., Boehm, M. F., et al. Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P(1)) and receptor-5 (S1P(5)) agonist with autoimmune disease-modifying activity British Journal of Pharmacology 2016 173:1778-1792 DOI:10.1111/bph.13476 PMID:26990079 PMCID:PMC4867749
- Guerrero, M., Urbano, M., Roberts, E. Sphingosine 1-phosphate receptor 1 agonists: a patent review (2013-2015) Expert Opinion on Therapeutic Patents 2016 26:455-470 DOI:10.1517/13543776.2016.1157165 PMID:26947494
- Dillmann, C., Ringel, C., Ringleb, J., Mora, J., Olesch, C., Fink, A. F., Roberts, E., Brüne, B., Weigert, A. S1PR4 signaling attenuates ILT 7 internalization to limit IFN-α production by human plasmacytoid dendritic cells Journal of Immunology 2016 196:1579-1590 DOI:10.4049/jimmunol.1403168 PMID:26783340
- Schreiber, S. L., Kotz, J. D., Li, M., Aube, J., Austin, C. P., Reed, J. C., Rosen, H., White, E. L., Sklar, L. A., Lindsley, C. W., Alexander, B. R., Bittker, J. A., et al. Advancing biological understanding and therapeutics discovery with small-molecule probes Cell 2015 161:1252-1265 DOI:10.1016/j.cell.2015.05.023 PMID:26046436 PMCID:PMC4564295
- Urbano, M., Guerrero, M., Rosen, H., Roberts, E. Antagonists of the kappa opioid receptor Bioorganic & Medicinal Chemistry Letters 2014 24:2021-2032 DOI:10.1016/j.bmcl.2014.03.040 PMID:24690494
- Mittapalli, G. K., Roberts, E. Structure activity relationships of novel antiepileptic drugs Current Medicinal Chemistry 2014 21:722-754 DOI:10.2174/0929867320666131119153215 PMID:24251563
- Mittapalli, G. K., Roberts, E. Ligands of the neuropeptide Y Y2 receptor Bioorganic & Medicinal Chemistry Letters 2014 24:430-441 DOI:10.1016/j.bmcl.2013.11.061 PMID:24365162 PMCID:PMC4672871
- Rosen, H., Sanna, M. G., Gonzalez-Cabrera, P. J., Roberts, E. The organization of the sphingosine 1-phosphate signaling system Current Topics in Microbiology and Immunology 2014 378:1-21 DOI:10.1007/978-3-319-05879-5_1 PMID:24728591
- Guerrero, M., Poddutoori, R., Urbano, M., Peng, X., Spicer, T. P., Chase, P. S., Hodder, P. S., Schaeffer, M. T., Brown, S., Rosen, H., Roberts, E. Discovery, design and synthesis of a selective S1P(3) receptor allosteric agonist Bioorganic & Medicinal Chemistry Letters 2013 23:6346-6349 DOI:10.1016/j.bmcl.2013.09.075 PMID:24135724 PMCID:PMC3963471
- Urbano, M., Guerrero, M., Rosen, H., Roberts, E. Modulators of the Sphingosine 1-phosphate receptor 1 Bioorganic & Medicinal Chemistry Letters 2013 23:6377-6389 DOI:10.1016/j.bmcl.2013.09.058 PMID:24125884 PMCID:PMC3926431
- Cencetti, F., Bernacchioni, C., Tonelli, F., Roberts, E., Donati, C., Bruni, P. TGF beta 1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P(4) transactivation upstream of Rho-kinase-2 activation FASEB Journal 2013 27:4532-4546 DOI:10.1096/fj.13-228528 PMID:23913862
- Satsu, H., Schaeffer, M. T., Guerrero, M., Saldana, A., Eberhart, C., Hodder, P., Cayanan, C., Schurer, S., Bhhatarai, B., Roberts, E., Rosen, H., Brown, S. J. A sphingosine 1-phosphate receptor 2 selective allosteric agonist Bioorganic & Medicinal Chemistry 2013 21:5373-5382 DOI:10.1016/j.bmc.2013.06.012 PMID:23849205 PMCID:PMC3786410
- Roberts, E., Guerrero, M., Urbano, M., Rosen, H. Sphingosine 1-phosphate receptor agonists: A patent review (2010 - 2012) Expert Opinion on Therapeutic Patents 2013 23:817-841 DOI:10.1517/13543776.2013.783022 PMID:23541049
- Guerrero, M., Urbano, M., Schaeffer, M. T., Brown, S., Rosen, H., Roberts, E. SAR analysis of novel non-peptidic NPBWR1 (GPR7) antagonists Bioorganic & Medicinal Chemistry Letters 2013 23:614-619 DOI:10.1016/j.bmcl.2012.12.030 PMID:23287738 PMCID:PMC3621982
- Cahalan, S. M., Gonzalez-Cabrera, P. J., Nguyen, N., Guerrero, M., Cisar, E. A. G., Leaf, N. B., Brown, S. J., Roberts, E., Rosen, H. Sphingosine 1-phosphate receptor 1 (S1P(1)) upregulation and amelioration of experimental autoimmune encephalomyelitis by an S1P(1) antagonist Molecular Pharmacology 2013 83:316-321 DOI:10.1124/mol.112.082958 PMID:23204443 PMCID:PMC3558813
- Gomes, I., Fujita, W., Gupta, A., Saldanha, A. S., Negri, A., Pinello, C. E., Roberts, E., Filizola, M., Hodder, P., Devi, L. A. Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity Proceedings of the National Academy of Sciences of the United States of America 2013 110:12072-12077 DOI:10.1073/pnas.1222044110 PMID:23818586 PMCID:PMC3718106
- Rosen, H., Stevens, R. C., Hanson, M., Roberts, E., Oldstone, M. B. A. Sphingosine-1-phosphate and its receptors: Structure, signaling, and influence Annual Review of Biochemistry 2013 82:637-662 DOI:10.1146/annurev-biochem-062411-130916 PMID:23527695
- Urbano, M., Guerrero, M., Zhao, J., Velaparthi, S., Saldanha, S. A., Chase, P., Wang, Z. W., Civelli, O., Hodder, P., Schaeffer, M. T., Brown, S., Rosen, H., et al. Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7) Bioorganic & Medicinal Chemistry Letters 2012 22:7135-7141 DOI:10.1016/j.bmcl.2012.09.074 PMID:23079522 PMCID:PMC3601546
- Jo, E. J., Bhhatarai, B., Repetto, E., Guerrero, M., Riley, S., Brown, S. J., Kohno, Y., Roberts, E., Schurer, S. C., Rosen, H. Novel selective allosteric and bitopic ligands for the S1P(3) receptor ACS Chemical Biology 2012 7:1975-1983 DOI:10.1021/cb300392z PMID:22971058 PMCID:PMC3528827
- Mittapalli, G. K., Vellucci, D., Yang, J., Toussaint, M., Brothers, S. P., Wahlestedt, C., Roberts, E. Synthesis and sar of selective small molecule neuropeptide y y2 receptor antagonists Bioorganic & Medicinal Chemistry Letters 2012 22:3916-3920 DOI:10.1016/j.bmcl.2012.04.107 PMID:22607676 PMCID:PMC3362798
- Liu, J., Chan, J., Bryant, C. M., Duspara, P. A., Lee, E. E., Powell, D., Yang, H., Liu, Z. P., Walpole, C., Roberts, E., Batey, R. A. Effect of acid catalysis on the direct electrophilic fluorination of ketones, ketals, and enamides using selectfluor (tm) Tetrahedron Letters 2012 53:2971-2975 DOI:10.1016/j.tetlet.2012.03.074
- Sekar, D., Hahn, C., Brune, B., Roberts, E., Weigert, A. Apoptotic tumor cells induce il-27 release from human dcs to activate treg cells that express cd69 and attenuate cytotoxicity European Journal of Immunology 2012 42:1585-1598 DOI:10.1002/eji.201142093 PMID:22678911 PMCID:PMC3679920
- Guerrero, M., Urbano, M., Zhao, J., Crisp, M., Chase, P., Hodder, P., Schaeffer, M. T., Brown, S., Rosen, H., Roberts, E. Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (s1p(4)-r) agonists Bioorganic & Medicinal Chemistry Letters 2012 22:537-542 DOI:10.1016/j.bmcl.2011.10.096 PMID:22119461 PMCID:PMC3248976
- Edwards, S., Guerrero, M., Ghoneim, O. M., Roberts, E., Koob, G. F. Evidence that vasopressin V(1b) receptors mediate the transition to excessive drinking in ethanol-dependent rats Addiction Biology 2012 17:76-85 DOI:10.1111/j.1369-1600.2010.00291.x PMID:21309953 PMCID:PMC3178679
- Sagi, V. N., Liu, T. Y., Lu, X. Y., Bartfai, T., Roberts, E. Synthesis and biological evaluation of novel pyrimidine derivatives as sub-micromolar affinity ligands of GalR2 Bioorganic & Medicinal Chemistry Letters 2011 21:7210-7215 DOI:10.1016/j.bmcl.2011.09.033 PMID:22018787 PMCID:PMC3278223
- Teijaro, J. R., Walsh, K. B., Cahalan, S., Fremgen, D. M., Roberts, E., Scott, F., Martinborough, E., Peach, R., Oldstone, M. B. A., Rosen, H. Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection Cell 2011 146:979-990 DOI:10.1016/j.cell.2011.08.015 PMID:21925319 PMCID:PMC3176439
- Urbano, M., Guerrero, M., Zhao, J., Velaparthi, S., Schaeffer, M. T., Brown, S., Rosen, H., Roberts, E. Sar analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (s1p(4)) receptor Bioorganic & Medicinal Chemistry Letters 2011 21:5470-5474 DOI:10.1016/j.bmcl.2011.06.132 PMID:21783362 PMCID:PMC3159836
- Guerrero, M., Urbano, M., Velaparthi, S., Zhao, J., Schaeffer, M. T., Brown, S., Rosen, H., Roberts, E. Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (s1p(4)) receptor antagonists Bioorganic & Medicinal Chemistry Letters 2011 21:3632-3636 DOI:10.1016/j.bmcl.2011.04.097 PMID:21570287 PMCID:PMC3107912
- Urbano, M., Guerrero, M., Velaparthi, S., Crisp, M., Chase, P., Hodder, P., Schaeffer, M. T., Brown, S., Rosen, H., Roberts, E. Discovery, synthesis and sar analysis of novel selective small molecule s1p(4)-r agonists based on a (2z,5z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-o ne chemotype Bioorganic & Medicinal Chemistry Letters 2011 21:6739-6745 DOI:10.1016/j.bmcl.2011.09.049 PMID:21982495 PMCID:PMC3209756
- Lu, X. Y., Roberts, E., Xia, F. C., Sanchez-Alavez, M., Liu, T. Y., Baldwin, R., Wu, S., Chang, J., Wasterlain, C. G., Bartfai, T. GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models Proceedings of the National Academy of Sciences of the United States of America 2010 107:15229-15234 DOI:10.1073/pnas.1008986107 PMID:20660766 PMCID:PMC2930524
- Montalban, A. G., Boman, E., Chang, C. D., Ceide, S. C., Dahl, R., Dalesandro, D., Delaet, N. G. J., Erb, E., Ernst, J. T., Gibbs, A., Kahl, J., Kessler, L., et al. Optimization of alpha-ketoamide based p38 inhibitors through modifications to the region that binds to the allosteric site Bioorganic & Medicinal Chemistry Letters 2010 20:4819-4824 DOI:10.1016/j.bmcl.2010.06.102 PMID:20663667
- Montalban, A. G., Boman, E., Chang, C. D., Ceide, S. C., Dahl, R., Dalesandro, D., Delaet, N. G. J., Erb, E., Ernst, J., Gibbs, A., Kahl, J., Kessler, L., et al. Kr-003048, a potent, orally active inhibitor of p38 mitogen-activated protein kinase European Journal of Pharmacology 2010 632:93-102 DOI:10.1016/j.ejphar.2010.01.011 PMID:20132813
- Jones, P., Griffin, A. M., Gawell, L., Lavoie, R., Delorme, D., Roberts, E., Brown, W., Walpole, C., Xiao, W. H., Boulet, J., Labarre, M., Coupal, M., et al. N,n-diethyl-4- (3-hydroxyphenyl)(piperidin-4-yl)amino benzamide derivatives: The development of diaryl amino piperidines as potent delta opioid receptor agonists with in vivo anti-nociceptive activity in rodent models Bioorganic & Medicinal Chemistry Letters 2009 19:5994-5998 DOI:10.1016/j.bmcl.2009.09.072 PMID:19800791
- Gonzalez-Cabrera, P. J., Jo, E., Sanna, M. G., Brown, S., Leaf, N., Marsolais, D., Schaeffer, M. T., Chapman, J., Cameron, M., Guerrero, M., Roberts, E., Rosen, H. Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions Molecular Pharmacology 2008 74:1308-1318 DOI:10.1124/mol.108.049783 PMID:18708635 PMCID:PMC2575047
- Montalban, A. G., Boman, E., Chang, C. D., Ceide, S. C., Dahl, R., Dalesandro, D., Delaet, N. G. J., Erb, E., Gibbs, A., Kahl, J., Kessler, L., Lundstrom, J., et al. 'Reverse' alpha-ketoamide-based p38 map kinase inhibitors Bioorganic & Medicinal Chemistry Letters 2008 18:5456-5459 DOI:10.1016/j.bmcl.2008.09.028 PMID:18835164
- Lum, C., Kahl, J., Kessler, L., Kucharski, J., Lundstrom, J., Miller, S., Nakanishi, H., Pei, Y. Z., Pryor, K., Roberts, E., Sebo, L., Sullivan, R., et al. 2,5-diaminopyrimidines and 3,5-disubstituted azapurines as inhibitors of glycogen synthase kinase-3 (GSK-3) Bioorganic & Medicinal Chemistry Letters 2008 18:3578-3581 DOI:10.1016/j.bmcl.2008.05.001 PMID:18502127
- Montalban, A. G., Boman, E., Chang, C. D., Ceide, S. C., Dahl, R., Dalesandro, D., Delaet, N. G. J., Erb, E., Ernst, J. T., Gibbs, A., Kahl, J., Kessler, L., et al. The design and synthesis of novel alpha-ketoamide-based p38 map kinase inhibitors Bioorganic & Medicinal Chemistry Letters 2008 18:1772-1777 DOI:10.1016/j.bmcl.2008.02.033 PMID:18325768
- Marsolais, D., Hahm, B., Edelmann, K. H., Walsh, K. B., Guerrero, M., Hatta, Y., Kawaoka, Y., Roberts, E., Oldstone, M. B. A., Rosen, H. Local not systemic modulation of dendritic cell s1p receptors in lung blunts virus-specific immune responses to influenza Molecular Pharmacology 2008 74:896-903 DOI:10.1124/mol.108.048769 PMID:18577684 PMCID:PMC2574812
- Don, A. S., Martinez-Lamenca, C., Webb, W. R., Proia, R. L., Roberts, E., Rosen, H. Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues Journal of Biological Chemistry 2007 282:15833-15842 DOI:10.1074/jbc.M609124200 PMID:17400555
- Roberts, E., Sancon, J. P., Sweeney, J. B. A new class of ammonium ylid for 2,3 -sigmatropic rearrangement reactions: Ene-endo-spiro ylids Organic Letters 2005 7:2075-2078 DOI:10.1021/ol050691+ PMID:15876058
- Roberts, E., Sancon, J. P., Sweeney, J. B., Workman, J. A. First efficient and general copper-catalyzed [2,3]-rearrangement of tetrahydropyridinium ylids Organic Letters 2003 5:4775-4777 DOI:10.1021/ol035747j PMID:14653671
- Heath, P., Roberts, E., Sweeney, J. B., Wessel, H. P., Workman, J. A. Copper(ii)-catalyzed [2,3]-sigmatropic rearrangement of n-methyltetrahydropyridinium ylids Journal of Organic Chemistry 2003 68:4083-4086 DOI:10.1021/jo04147v PMID:12737596
- Alanine, A., Nettekoven, M., Roberts, E., Thomas, A. W. Lead generation - enhancing the success of drug discovery by investing in the hit to lead process Combinatorial Chemistry & High Throughput Screening 2003 6:51-66 PMID:12570752
- Chismar, J. D., Mondala, T., Fox, H. S., Roberts, E., Langford, D., Masliah, E., Salomon, D. R., Head, S. R. Analysis of result variability from high-density oligonucleotide arrays comparing same-species and cross-species hybridizations Biotechniques 2002 33:516-518, 520, 522 passim PMID:12238761
- Carpenter, K. A., Schmidt, R., von Mentzer, B., Haglund, U., Roberts, E., Walpole, C. Turn structures in cgrp c-terminal analogues promote stable arrangements of key residue side chains Biochemistry 2001 40:8317-8325 DOI:10.1021/bi0102860 PMID:11444978
- Wei, Z. Y., Brown, W., Takasaki, B., Plobeck, N., Delorme, D., Zhou, F., Yang, H., Jones, P., Gawell, L., Gagnon, H., Schmidt, R., Yue, S. Y., et al. N,n-diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide: A novel, exceptionally selective, potent delta opioid receptor agonist with oral bioavailability and its analogues Journal of Medicinal Chemistry 2000 43:3895-3905 DOI:10.1021/jm000229p PMID:11052794
- Plobeck, N., Delorme, D., Wei, Z. Y., Yang, H., Zhou, F., Schwarz, P., Gawell, L., Gagnon, H., Pelcman, B., Schmidt, R., Yue, S. Y., Walpole, C., et al. New diarylmethylpiperazines as potent and selective nonpeptidic delta opioid receptor agonists with increased in vitro metabolic stability Journal of Medicinal Chemistry 2000 43:3878-3894 DOI:10.1021/jm000228x PMID:11052793
- Yang, H., Foster, K., Stephenson, C. R. J., Brown, W., Roberts, E. Asymmetric wolff rearrangement reactions with alpha-alkylated-alpha-diazoketones: Stereoselective synthesis of alpha-substituted-beta-amino acid derivatives Organic Letters 2000 2:2177-2179 DOI:10.1021/ol006146k PMID:10891260
- Yang, H., Jurkauskas, V., Mackintosh, N., Mogren, T., Stephenson, C. R. J., Foster, K., Brown, W., Roberts, E. Trifluoroacetic acid-mediated intramolecular formal n-h insertion reactions with amino-alpha-diazoketones: A facile and efficient synthesis of optically pure pyrrolidinones and piperidinones Canadian Journal of Chemistry-Revue Canadienne De Chimie 2000 78:800-808 DOI:10.1139/cjc-78-6-800
- Carpenter, K. A., Schmidt, R., Yue, S. Y., Hodzic, L., Pou, C., Payza, K., Godbout, C., Brown, W., Roberts, E. The glycine residue in cyclic lactam analogues of galanin(1-16)-nh2 is important for stabilizing an n-terminal helix Biochemistry 1999 38:15295-15304 DOI:10.1021/bi991081i PMID:10563815
- Horwell, D. C., Kneen, C. O., Pritchard, M. C., Ratcliffe, G. S., Roberts, E., SumanChauhan, N., Steiner, K., Betche, H. J. Design and synthesis of a targeted set of aromatic amino acid derivatives for identification of new lead compounds Bioorganic & Medicinal Chemistry Letters 1997 7:1957-1962 DOI:10.1016/s0960-894x(97)00346-6
- Hudson, R. D. A., Osborne, S. A., Roberts, E., Stephenson, G. R. Long-range asymmetric induction by conjugate addition to alkenylcyclohexadienyliron complexes Tetrahedron Letters 1996 37:9009-9012 DOI:10.1016/s0040-4039(96)02115-6
- Horwell, D. C., Morrell, A. I., Roberts, E. The design and synthesis of non-peptide ligands with affinity and selectivity for tachykinin receptors Bioorganic & Medicinal Chemistry Letters 1996 6:165-166 DOI:10.1016/0960-894x(95)00582-e
- Singh, L., Field, M. J., Hill, D. R., Horwell, D. C., McKnight, A. T., Roberts, E., Tang, K. W., Woodruff, G. N. Peptoid cck receptor antagonists: Pharmacological evaluation of ccka, cckb and mixed ccka/b receptor antagonists European Journal of Pharmacology 1995 286:185-191 DOI:10.1016/0014-2999(95)00445-q PMID:8605955
- Horwell, D. C., Morrell, A. I., Roberts, E. Cyclobutylcarbinyl radical cleavage in the bicyclo[3.2.0]heptanone ring-system Tetrahedron Letters 1995 36:459-460 DOI:10.1016/0040-4039(94)02285-j
- Horwell, D. C., Nichols, P. D., Roberts, E. Methionine replacements in biologically-active peptides Bioorganic & Medicinal Chemistry Letters 1994 4:2263-2266 DOI:10.1016/0960-894x(94)85022-4
- Horwell, D. C., Nichols, P. D., Ratcliffe, G. S., Roberts, E. Synthesis of conformationally constrained tryptophan derivatives Journal of Organic Chemistry 1994 59:4418-4423 DOI:10.1021/jo00095a015
- Genet, J. P., Hudson, R. D. A., Meng, W. D., Roberts, E., Stephenson, G. R., Thorimbert, S. Schiff-base nucleophiles - progress towards the general application of organoiron complexes in amino-acid synthesis Synlett 1994 631-634
- Horwell, D. C., Lennon, I. C., Roberts, E. A facile method to append peptidal side-chains onto steroidal templates Tetrahedron 1994 50:4225-4234 DOI:10.1016/s0040-4020(01)86716-8
- Horwell, D. C., Morrell, A. I., Roberts, E. Formation of the oxatricyclo[3.2.1.0(3,6)]octane ring-system via an intramolecular bromoetherification Tetrahedron Letters 1994 35:2221-2222 DOI:10.1016/s0040-4039(00)76802-x
- Horwell, D. C., Lennon, I. C., Roberts, E. Alternative strategies towards the identification of chemical lead compounds by rational design Bioorganic & Medicinal Chemistry Letters 1994 4:525-530 DOI:10.1016/0960-894x(94)80030-8
- Horwell, D. C., Nichols, P. D., Roberts, E. Conformationally constrained amino-acids - synthesis of novel 3,4-cyclized tryptophans Tetrahedron Letters 1994 35:939-940 DOI:10.1016/s0040-4039(00)76005-9
- Higginbottom, M., Horwell, D. C., Roberts, E. Selective ligands for cholecystokinin receptor subtypes cck-a and cck-b within a single structural class Bioorganic & Medicinal Chemistry Letters 1993 3:881-884 DOI:10.1016/s0960-894x(00)80685-x
- Higginbottom, M., Nolan, W., Otoole, J., Ratcliffe, G. S., Rees, D. C., Roberts, E. The design and synthesis of kappa-opioid ligands based on a binding model for kappa agonists Bioorganic & Medicinal Chemistry Letters 1993 3:841-846 DOI:10.1016/s0960-894x(00)80677-0
- Boden, P. R., Higginbottom, M., Hill, D. R., Horwell, D. C., Hughes, J., Rees, D. C., Roberts, E., Singh, L., Sumanchauhan, N., Woodruff, G. N. Cholecystokinin dipeptoid antagonists: Design, synthesis, and anxiolytic profile of some novel cck-a and cck-b selective and "mixed" cck-a/cck-b antagonists Journal of Medicinal Chemistry 1993 36:552-565 DOI:10.1021/jm00057a005 PMID:7684452
- Boden, P. R., Eden, J. M., Higginbottom, M., Hill, D. R., Horwell, D. C., Hunter, J. C., Martin, K., Pritchard, M. C., Richardson, R. S., Roberts, E. Rationally designed ‘dipeptoid’ analogues of cholecystokinin (CCK): C-terminal structure-activity relationships of α-methyl tryptophan derivatives European Journal of Medicinal Chemistry 1993 28:47-61 DOI:10.1016/0223-5234(93)90078-s
- Eden, J. M., Higginbottom, M., Hill, D. R., Horwell, D. C., Hunter, J. C., Martin, K., Pritchard, M. C., Rahman, S. S., Richardson, R. S., Roberts, E. Rationally designed ‘dipeptoid’ analogues of cholecystokinin (CCK): N-terminal structure-affinity relationships of α-methyl-tryptophan derivatives European Journal of Medicinal Chemistry 1993 28:37-45 DOI:10.1016/0223-5234(93)90077-r
- Fincham, C. I., Higginbottom, M., Hill, D. R., Horwell, D. C., Otoole, J. C., Ratcliffe, G. S., Rees, D. C., Roberts, E. Amide bond replacements incorporated into cck-b selective "dipeptoids" Journal of Medicinal Chemistry 1992 35:1472-1484 DOI:10.1021/jm00086a017 PMID:1573640
- Horwell, D. C., Hughes, J., Hunter, J. C., Pritchard, M. C., Richardson, R. S., Roberts, E., Woodruff, G. N. Rationally designed "dipeptoid" analogues of cck. Alpha-methyltryptophan derivatives as highly selective and orally active gastrin and cck-b antagonists with potent anxiolytic properties Journal of Medicinal Chemistry 1991 34:404-414 DOI:10.1021/jm00105a062 PMID:1671419
- Horwell, D. C., Ratcliffe, G., Roberts, E. Stabilities of tryptophanylphenethylamides to acid and alkaline conditions Bioorganic & Medicinal Chemistry Letters 1991 1:169-172 DOI:10.1016/s0960-894x(01)80793-9
- Jackson, A. H., Pandey, R. K., Rao, K. R. N., Roberts, E. Reactions on solid supports .2. A convenient method for synthesis of pyrromethanes using a montmorillonite clay as catalyst Tetrahedron Letters 1985 26:793-796 DOI:10.1016/s0040-4039(00)89139-x
- Jackson, A. H., Pandey, R. K., Roberts, E. Total synthesis of an n-methylporphyrin Journal of the Chemical Society-Chemical Communications 1985 470-471 DOI:10.1039/c39850000470
- Cimarusti, D. L., Saito, K., Vaughn, J. E., Barber, R., Roberts, E., Thomas, P. E. Immunocytochemical localization of dopamine-beta-hydroxylase in rat locus coeruleus and hypothalamus Brain Research 1979 162:55-67 DOI:10.1016/0006-8993(79)90755-8 PMID:367530
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- Guerrero, M., Poddutoori, R., Pinacho-Crisostomo, F., Schaeffer, M. T., Brown, S. J., Spicer, T., Chase, P., Ferguson, J., Roberts, E., Sanna, G., Hodder, P., Rosen, H. Probe development efforts for an allosteric agonist of the sphingosine 1-phosphate receptor 3 (S1P3) Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:23658964
