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Roberts, Amanda
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Roberts, Amanda

Non-Faculty Academic
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Positions

  • 2018 - Director, Animal Models Core, Scripps Research
  • 2017 - 2018 Associate Professor of Neuroscience, Neuroscience , Scripps Research
  • 2013 - 2017 Associate Professor of Molecular Neurosciences, Molecular and Cellular Neuroscience (MCN) , Scripps Research
  • 2007 - 2012 Associate Professor of Molecular Neurosciences, Molecular and Integrative Neurosciences (MIND) , Scripps Research
  • 2010 - 2011 Visiting Associate Professor, Department of Psychology, University of California, San Diego
  • 2006 - 2010 Visiting Assistant Professor, Department of Psychology, University of California, San Diego
  • 2000 - 2007 Assistant Professor, Neuropharmacology , Scripps Research
  • 1999 - 2006 Lecturer, Department of Psychology, University of California, San Diego
  • 1998 - 2000 Staff Scientist & Laboratory Manager with Dr. George F. Koob, Neuropharmacology , Scripps Research
  • 1995 - 1997 Postdoctoral Research Associate with Dr. George F. Koob, Neuropharmacology , Scripps Research
  • 1993 - 1994 Postdoctoral Research Associate with Dr. Tamara J. Phillips, Oregon Health & Science University
Dr. Amanda Roberts investigates the neural bases of motivated behaviors such as drug self-administration, exploratory drive, and feeding.

Research Areas research areas

  • Mental Illness (UMLS)

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  • aroberts@scripps.edu
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Publications

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    • Gruol, D. L., Melkonian, C., Ly, K., Sisouvanthong, J., Tan, Y., Roberts, A. J. Alcohol and IL-6 Alter Expression of Synaptic Proteins in Cerebellum of Transgenic Mice with Increased Astrocyte Expression of IL-6 Neuroscience  2020 442:124-137  DOI:10.1016/j.neuroscience.2020.06.043  PMID:32634532  PMCID:PMC7438304
    • Singh, H., Ojeda-Juarez, D., Maung, R., Shah, R., Roberts, A. J., Kaul, M. A pivotal role for Interferon-α receptor-1 in neuronal injury induced by HIV-1 Journal of Neuroinflammation  2020 17  DOI:10.1186/s12974-020-01894-2  PMID:32727588  PMCID:PMC7388458
    • Gruol, D. L., Hernandez, R. V., Roberts, A. Alcohol Enhances Responses to High Frequency Stimulation in Hippocampus from Transgenic Mice with Increased Astrocyte Expression of IL-6 Cellular and Molecular Neurobiology  2020  DOI:10.1007/s10571-020-00902-6  PMID:32562098
    • Gruol, D. L., Melkonian, C., Huitron-Resendiz, S., Roberts, A. J. Alcohol alters IL-6 Signal Transduction in the CNS of Transgenic Mice with Increased Astrocyte Expression of IL-6 Cellular and Molecular Neurobiology  2020  DOI:10.1007/s10571-020-00879-2  PMID:32447612
    • Xu, J., Ma, H. Y., Liu, X., Rosenthal, S., Baglieri, J., McCubbin, R., Sun, M., Koyama, Y., Geoffroy, C. G., Saijo, K., Shang, L., Nishio, T., et al. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice Jci Insight  2020 5  DOI:10.1172/jci.insight.131277  PMID:32051339  PMCID:PMC7098802
    • Roberts, A. J., Khom, S., Bajo, M., Vlkolinsky, R., Polis, I., Cates-Gatto, C., Roberto, M., Gruol, D. L. Increased IL-6 expression in astrocytes is associated with emotionality, alterations in central amygdala GABAergic transmission, and excitability during alcohol withdrawal Brain Behavior and Immunity  2019 82:188-202  DOI:10.1016/j.bbi.2019.08.185  PMID:31437534  PMCID:PMC6800653
    • Pinto-Duarte, A., Roberts, A. J., Ouyang, K. F., Sejnowski, T. J. Impairments in remote memory caused by the lack of Type 2 IP3 receptors Glia  2019 67:1976-1989  DOI:10.1002/glia.23679  PMID:31348567
    • Blednov, Y. A., Bajo, M., Roberts, A. J., Da Costa, A. J., Black, M., Edmunds, S., Mayfield, J., Roberto, M., Homanics, G. E., Lasek, A. W., Hitzemann, R. J., Harris, R. A. Scn4b regulates the hypnotic effects of ethanol and other sedative drugs Genes Brain and Behavior  2019 18  DOI:10.1111/gbb.12562  PMID:30817077  PMCID:PMC6612599
    • Patel, R. R., Khom, S., Steinman, M. Q., Varodayan, F. P., Kiosses, W. B., Hedges, D. M., Vlkolinsky, R., Nadav, T., Polis, I., Bajo, M., Roberts, A. J., Roberto, M. IL-1β expression is increased and regulates GABA transmission following chronic ethanol in mouse central amygdala Brain Behavior and Immunity  2019 75:208-219  DOI:10.1016/j.bbi.2018.10.009
    • Ogasawara, D., Ichu, T. A., Vartabedian, V. F., Benthuysen, J., Jing, H., Reed, A., Ulanovskaya, O. A., Hulce, J. J., Roberts, A., Brown, S., Rosen, H., Teijaro, J. R., et al. Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo Nature Chemical Biology  2018 14:1099-1108  DOI:10.1038/s41589-018-0155-8  PMID:30420694  PMCID:PMC6263940
    • Courchet, V., Roberts, A. J., Meyer-Dilhet, G., Del Carmine, P., Lewis, T. L., Polleux, F., Courchet, J. Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice Nature Communications  2018 9  DOI:10.1038/s41467-018-06584-5  PMID:30327473  PMCID:PMC6191442
    • Huang, L., Shum, E. Y., Jones, S. H., Lou, C. H., Dumdie, J., Kim, H., Roberts, A. J., Jolly, L. A., Espinoza, J. L., Skarbrevik, D. M., Phan, M. H., Cook-Andersen, H., et al. A Upf3b-mutant mouse model with behavioral and neurogenesis defects Molecular Psychiatry  2018 23:1773-1786  DOI:10.1038/mp.2017.173  PMID:28948974  PMCID:PMC5869067
    • Gruol, D. L., Huitron-Resendiz, S., Roberts, A. J. Altered brain activity during withdrawal from chronic alcohol is associated with changes in IL-6 signal transduction and GABAergic mechanisms in transgenic mice with increased astrocyte expression of IL-6 Neuropharmacology  2018 138:32-46  DOI:10.1016/j.neuropharm.2018.05.024  PMID:29787738
    • Long, J. Z., Roche, A. M., Berdan, C. A., Louie, S. M., Roberts, A. J., Svensson, K. J., Dou, F. Y., Bateman, L. A., Mina, A. I., Deng, Z. M., Jedrychowski, M. P., Lin, H., et al. Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociception Proceedings of the National Academy of Sciences of the United States of America  2018 115:E6937-E6945  DOI:10.1073/pnas.1803389115  PMID:29967167  PMCID:PMC6055169
    • Bray, J. G., Reyes, K. C., Roberts, A. J., Gruol, D. L. Altered hippocampal synaptic function in transgenic mice with increased astrocyte expression of CCL2 after withdrawal from chronic alcohol Neuropharmacology  2018 135:113-125  DOI:10.1016/j.neuropharm.2018.02.031  PMID:29499275  PMCID:PMC5975123
    • Roberts, A. J., Casal, L., Huitron-Resendiz, S., Thompson, T., Tarantino, L. M. Intravenous cocaine self-administration in a panel of inbred mouse strains differing in acute locomotor sensitivity to cocaine Psychopharmacology  2018 235:1179-1189  DOI:10.1007/s00213-018-4834-7  PMID:29423710  PMCID:PMC5874174
    • Huitron-Resendiz, S., Nadav, T., Krause, S., Cates-Gatto, C., Polis, I., Roberts, A. J. Effects of withdrawal from chronic intermittent ethanol exposure on sleep characteristics of female and male mice Alcoholism-Clinical and Experimental Research  2018 42:540-550  DOI:10.1111/acer.13584  PMID:29265376  PMCID:PMC5832570
    • Song, T., Liang, S., Liu, J., Zhang, T., Yin, Y., Geng, C., Gao, S., Feng, Y., Xu, H., Guo, D., Roberts, A., Gu, Y., et al. CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory PLoS Genetics  2018 14  DOI:10.1371/journal.pgen.1007165  PMID:29370161
    • Juarez, B., Morel, C., Ku, S. M., Liu, Y., Zhang, H., Montgomery, S., Gregoire, H., Ribeiro, E., Crumiller, M., Roman-Ortiz, C., Walsh, J. J., Jackson, K., et al. Midbrain circuit regulation of individual alcohol drinking behaviors in mice Nature Communications  2017 8  DOI:10.1038/s41467-017-02365-8  PMID:29263389  PMCID:PMC5738419
    • Tu, S., Akhtar, M. W., Escorihuela, R. M., Amador-Arjona, A., Swarup, V., Parker, J., Zaremba, J. D., Holland, T., Bansal, N., Holohan, D. R., Lopez, K., Ryan, S. D., et al. NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism Nature Communications  2017 8  DOI:10.1038/s41467-017-01563-8  PMID:29133852  PMCID:PMC5684358
    • Harris, R. A., Bajo, M., Bell, R. L., Blednov, Y. A., Varodayan, F. P., Truitt, J. M., de Guglielmo, G., Lasek, A. W., Logrip, M. L., Vendruscolo, L. F. Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents Journal of Neuroscience  2017 37:1139-1155  DOI:10.1523/jneurosci.2002-16.2016  PMID:27986929  PMCID:PMC5296793
    • Zhou, B., Eubanks, L. M., Jacob, N. T., Ellis, B., Roberts, A. J., Janda, K. D. Studies towards the improvement of an anti-cocaine monoclonal antibody for treatment of acute overdose Bioorganic & Medicinal Chemistry Letters  2016 26:5078-5081  DOI:10.1016/j.bmcl.2016.08.081  PMID:27599743  PMCID:PMC5050165
    • Bajo, M., Montgomery, S. E., Cates, L. N., Nadav, T., Delucchi, A. M., Cheng, K., Yin, H., Crawford, E. F., Roberts, A. J., Roberto, M. Evaluation of TLR4 inhibitor, T5342126, in modulation of ethanol-drinking behavior in alcohol-dependent mice Alcohol and Alcoholism  2016 51:541-548  DOI:10.1093/alcalc/agw026  PMID:27151970  PMCID:PMC5004745
    • Schweitzer, P., Cates-Gatto, C., Varodayan, F. P., Nadav, T., Roberto, M., Lasek, A. W., Roberts, A. J. Dependence-induced ethanol drinking and GABA neurotransmission are altered in Alk deficient mice Neuropharmacology  2016 107:1-8  DOI:10.1016/j.neuropharm.2016.03.003  PMID:26946429  PMCID:PMC4912883
    • Prior, M., Goldberg, J., Chiruta, C., Farrokhi, C., Kopynets, M., Roberts, A. J., Schubert, D. Selecting for neurogenic potential as an alternative for Alzheimer's disease drug discovery Alzheimers & Dementia  2016 12:678-686  DOI:10.1016/j.jalz.2016.03.016  PMID:27149904
    • Hernandez, R. V., Puro, A. C., Manos, J. C., Huitron-Resendiz, S., Reyes, K. C., Liu, K., Vo, K., Roberts, A. J., Gruol, D. L. Transgenic mice with increased astrocyte expression of IL-6 show altered effects of acute ethanol on synaptic function Neuropharmacology  2016 103:27-43  DOI:10.1016/j.neuropharm.2015.12.015  PMID:26707655  PMCID:PMC4755829
    • Sanna, P. P., Kawamura, T., Chen, J., Koob, G. F., Roberts, A. J., Vendruscolo, L. F., Repunte-Canonigo, V. 11β-hydroxysteroid dehydrogenase inhibition as a new potential therapeutic target for alcohol abuse Translational Psychiatry  2016 6  DOI:10.1038/tp.2016.13  PMID:26978742  PMCID:PMC4872439
    • Huitron-Resendiz, S., Roberts, A. J., Kamenecka, T. M., Solt, L. A., Burris, T. P. Pharmacological targeting the REV-ERBs in sleep/wake regulation PLoS One  2016 11  DOI:10.1371/journal.pone.0162452  PMID:27603791  PMCID:PMC5014418
    • Kreifeldt, M., Cates-Gatto, C., Roberts, A. J., Contet, C. BK channel β1 subunit contributes to behavioral adaptations elicited by chronic intermittent ethanol exposure Alcoholism-Clinical and Experimental Research  2015 39:2394  DOI:10.1111/acer.12911  PMID:26578345  PMCID:PMC4712106
    • Kang-Park, M., Kieffer, B. L., Roberts, A. J., Siggins, G. R., Moore, S. D. Interaction of CRF and kappa opioid systems on GABAergic neurotransmission in the mouse central amygdala Journal of Pharmacology and Experimental Therapeutics  2015 355:206-211  DOI:10.1124/jpet.115.225870  PMID:26350161  PMCID:PMC4613963
    • Herman, M. A., Sidhu, H., Stouffer, D. G., Kreifeldt, M., Le, D., Cates-Gatto, C., Munoz, M. B., Roberts, A. J., Parsons, L. H., Roberto, M., Wickman, K., Slesinger, P. A., et al. GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol Proceedings of the National Academy of Sciences of the United States of America  2015 112:7091-7096  DOI:10.1073/pnas.1416146112  PMID:25964320  PMCID:PMC4460485
    • Bajo, M., Varodayan, F. P., Madamba, S. G., Roberts, A. J., Casal, L. M., Oleata, C. S., Siggins, G. R., Roberto, M. IL-1 interacts with ethanol effects on GABAergic transmission in the mouse central amygdala Frontiers in Pharmacology  2015 6:49  DOI:10.3389/fphar.2015.00049  PMID:25852553  PMCID:PMC4365713
    • Hauser, S. R., Hedlund, P. B., Roberts, A. J., Sari, Y., Bell, R. L., Engleman, E. A. The 5-HT7 receptor as a potential target for treating drug and alcohol abuse Frontiers in Neuroscience  2015 8:448-448  DOI:10.3389/fnins.2014.00448  PMID:25628528  PMCID:PMC4292232
    • Jackson, E., Demarest, K., Eckert, W. J., Cates-Gatto, C., Nadav, T., Cates, L. N., Howard, H., Roberts, A. J. Aspen shaving versus chip bedding: effects on breeding and behavior Laboratory Animals  2015 49:46-56  DOI:10.1177/0023677214553320  PMID:25260358
    • Hoefer, M. M., Sanchez, A. B., Maung, R., de Rozieres, C. M., Catalan, I. C., Dowling, C. C., Thaney, V. E., Pina-Crespo, J., Zhang, D., Roberts, A. J., Kaul, M. Combination of methamphetamine and HIV-1 gp120 causes distinct long-term alterations of behavior, gene expression, and injury in the central nervous system Experimental Neurology  2015 263:221-234  DOI:10.1016/j.expneurol.2014.09.010  PMID:25246228  PMCID:PMC4370186
    • Kurczy, M. E., Zhu, Z. J., Ivanisevic, J., Schuyler, A. M., Lalwani, K., Santidrian, A. F., David, J. M., Giddabasappa, A., Roberts, A. J., Olivos, H. J., O'Brien, P. J., Franco, L., et al. Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids Nature Communications  2015 6:5998  DOI:10.1038/ncomms6998  PMID:25601659  PMCID:PMC4454288
    • Banerjee, S., Wang, Y., Solt, L. A., Griffett, K., Kazantzis, M., Amador, A., El-Gendy, B. M., Huitron-Resendiz, S., Roberts, A. J., Shin, Y., Kamenecka, T. M., Burris, T. P. Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour Nature Communications  2014 5:5759  DOI:10.1038/ncomms6759  PMID:25536025  PMCID:PMC4495958
    • Maung, R., Hoefer, M. M., Sanchez, A. B., Sejbuk, N. E., Medders, K. E., Desai, M. K., Catalan, I. C., Dowling, C. C., de Rozieres, C. M., Garden, G. A., Russo, R., Roberts, A. J., et al. CCR5 knockout prevents neuronal injury and behavioral impairment induced in a transgenic mouse model by a CXCR4-using HIV-1 glycoprotein 120 Journal of Immunology  2014 193:1895-1910  DOI:10.4049/jimmunol.1302915  PMID:25031461  PMCID:PMC4370188
    • Lee, H. S., Ghetti, A., Pinto-Duarte, A., Wang, X., Dziewczapolski, G., Galimi, F., Huitron-Resendiz, S., Pina-Crespo, J. C., Roberts, A. J., Verma, I. M., Sejnowski, T. J., Heinemann, S. F. Astrocytes contribute to gamma oscillations and recognition memory Proceedings of the National Academy of Sciences of the United States of America  2014 111:E3343-E3352  DOI:10.1073/pnas.1410893111  PMID:25071179  PMCID:PMC4136580
    • Vendruscolo, L. F., Roberts, A. J. Operant alcohol self-administration in dependent rats: focus on the vapor model Alcohol  2014 48:277-286  DOI:10.1016/j.alcohol.2013.08.006  PMID:24290310  PMCID:PMC4007394
    • Repunte-Canonigo, V., Chen, J., Lefebvre, C., Kawamura, T., Kreifeldt, M., Basson, O., Roberts, A. J., Sanna, P. P. MeCP2 regulates ethanol sensitivity and intake Addiction Biology  2014 19:791-799  DOI:10.1111/adb.12047  PMID:23448145  PMCID:PMC3692583
    • Gorini, G., Roberts, A. J., Mayfield, R. D. Neurobiological signatures of alcohol dependence revealed by protein profiling PLoS One  2013 8:e82656  DOI:10.1371/journal.pone.0082656  PMID:24358215  PMCID:PMC3865151
    • Zorrilla, E. P., Roberts, A. J., Rivier, J. E., Koob, G. F. Anxiolytic-Like Effects of Antisauvagine-30 in Mice Are Not Mediated by CRF2 Receptors PLoS One  2013 8:e63942  DOI:10.1371/journal.pone.0063942  PMID:24015170  PMCID:PMC3756045
    • Talantova, M., Sanz-Blasco, S., Zhang, X. F., Xia, P., Akhtar, M. W., Okamoto, S., Dziewczapolski, G., Nakamura, T., Cao, G., Pratt, A. E., Kang, Y. J., Tu, S., et al. Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss Proceedings of the National Academy of Sciences of the United States of America  2013 110:E2518-E2527  DOI:10.1073/pnas.1306832110  PMID:23776240  PMCID:PMC3704025
    • Li, X., Risbrough, V. B., Cates-Gatto, C., Kaczanowska, K., Finn, M. G., Roberts, A. J., Markou, A. Comparison of the effects of the GABA(B) receptor positive modulator BHF177 and the GABA(B) receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice Neuropharmacology  2013 70:156-167  DOI:10.1016/j.neuropharm.2013.01.018  PMID:23376712  PMCID:PMC3644349
    • Cates, L. N., Roberts, A. J., Huitron-Resendiz, S., Hedlund, P. B. Effects of lurasidone in behavioral models of depression. Role of the 5-HT7 receptor subtype Neuropharmacology  2013 70:211-217  DOI:10.1016/j.neuropharm.2013.01.023  PMID:23416039
    • Kang-Park, M., Kieffer, B. L., Roberts, A. J., Siggins, G. R., Moore, S. D. Kappa-opioid receptors in the central amygdala regulate ethanol actions at presynaptic GABAergic sites Journal of Pharmacology and Experimental Therapeutics  2013 346:130-137  DOI:10.1124/jpet.112.202903  PMID:23587526  PMCID:PMC3684840
    • Bray, J. G., Reyes, K. C., Roberts, A. J., Ransohoff, R. M., Gruol, D. L. Synaptic plasticity in the hippocampus shows resistance to acute ethanol exposure in transgenic mice with astrocyte-targeted enhanced CCL2 expression Neuropharmacology  2013 67:115-125  DOI:10.1016/j.neuropharm.2012.11.007  PMID:23164616  PMCID:PMC3595200
    • Eisener-Dorman, A. F., Bailey, J. S., Grabowski-Boase, L., Huitron-Resendiz, S., Roberts, A. J., Wiltshire, T., Tarantino, L. M. Characterization of highper, an enu-induced mouse mutant with abnormal psychostimulant and stress responses Psychopharmacology  2013 225:407-419  DOI:10.1007/s00213-012-2827-5  PMID:22948668  PMCID:PMC3536991
    • Semenova, S., Contet, C., Roberts, A. J., Markou, A. Mice lacking the beta4 subunit of the nicotinic acetylcholine receptor show memory deficits, altered anxiety- and depression-like behavior, and diminished nicotine-induced analgesia Nicotine & Tobacco Research  2012 14:1346-1355  DOI:10.1093/ntr/nts107  PMID:22573727  PMCID:PMC3482014
    • Roberts, A. J., Hedlund, P. B. The 5-HT(7) receptor in learning and memory Hippocampus  2012 22:762-771  DOI:10.1002/hipo.20938  PMID:21484935  PMCID:PMC3310936
    • Chang, Y., She, Z. G., Sakimura, K., Roberts, A., Kucharova, K., Rowitch, D. H., Stallcup, W. B. Ablation of NG2 proteoglycan leads to deficits in brown fat function and to adult onset obesity PLoS One  2012 7:e30637  DOI:10.1371/journal.pone.0030637  PMID:22295099  PMCID:PMC3266271
    • Chen, Q., Prior, M., Dargusch, R., Roberts, A., Riek, R., Eichmann, C., Chiruta, C., Akaishi, T., Abe, K., Maher, P., Schubert, D. A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease PLoS One  2011 6:e27865  DOI:10.1371/journal.pone.0027865  PMID:22194796  PMCID:PMC3237323
    • Amador-Arjona, A., Elliott, J., Miller, A., Ginbey, A., Pazour, G. J., Enikolopov, G., Roberts, A. J., Terskikh, A. V. Primary cilia regulate proliferation of amplifying progenitors in adult hippocampus: Implications for learning and memory Journal of Neuroscience  2011 31:9933-9944  DOI:10.1523/jneurosci.1062-11.2011  PMID:21734285
    • Treweek, J. B., Roberts, A. J., Janda, K. D. Immunopharmacotherapeutic manifolds and modulation of cocaine overdose Pharmacology, Biochemistry and Behavior  2011 98:474-484  DOI:10.1016/j.pbb.2011.02.020  PMID:21356233  PMCID:PMC3069656
    • Trujillo, J. L., Do, D. T., Grahame, N. J., Roberts, A. J., Gorman, M. R. Ethanol consumption in mice: Relationships with circadian period and entrainment Alcohol  2011 45:147-159  DOI:10.1016/j.alcohol.2010.08.016  PMID:20880659  PMCID:PMC4878854
    • Treweek, J. B., Roberts, A. J., Janda, K. D. Superadditive effects of ethanol and flunitrazepam: Implications of using immunopharmacotherapy as a therapeutic Molecular Pharmaceutics  2010 7:2056-2068  DOI:10.1021/mp900293a  PMID:20849117  PMCID:PMC2997924
    • Zhou, X., Nie, Z., Roberts, A., Zhang, D., Sebat, J., Malhotra, D., Kelsoe, J. R., Geyer, M. A. Reduced NMDAR1 expression in the Sp4 hypomorphic mouse may contribute to endophenotypes of human psychiatric disorders Human Molecular Genetics  2010 19:3797-3805  DOI:10.1093/hmg/ddq298  PMID:20634195  PMCID:PMC2935857
    • Repunte-Canonigo, V., Berton, F., Cottone, P., Reifel-Miller, A., Roberts, A. J., Morales, M., Francesconi, W., Sanna, P. P. A potential role for adiponectin receptor 2 (AdipoR2) in the regulation of alcohol intake Brain Research  2010 1339:11-17  DOI:10.1016/j.brainres.2010.03.060  PMID:20380822  PMCID:PMC2906226
    • Repunte-Canonigo, V., van der Stap, L. D., Chen, J. H., Sabino, V., Wagner, U., Zorrilla, E. P., Schumann, G., Roberts, A. J., Sanna, P. P. Genome-wide gene expression analysis identifies K-ras as a regulator of alcohol intake Brain Research  2010 1339:1-10  DOI:10.1016/j.brainres.2010.03.063  PMID:20388501  PMCID:PMC2925131
    • Sarkisyan, G., Roberts, A. J., Hedlund, P. B. The 5-HT(7) receptor as a mediator and modulator of antidepressant-like behavior Behavioural Brain Research  2010 209:99-108  DOI:10.1016/j.bbr.2010.01.022  PMID:20097233  PMCID:PMC2832919
    • Roberts, A. J., Maung, R., Sejbuk, N. E., Ake, C., Kaul, M. Alteration of methamphetamine-induced stereotypic behaviour in transgenic mice expressing hiv-1 envelope protein gp120 Journal of Neuroscience Methods  2010 186:222-225  DOI:10.1016/j.jneumeth.2009.11.007  PMID:19917310  PMCID:PMC3432271
    • Carmona, M. A., Murai, K. K., Wang, L., Roberts, A. J., Pasquale, E. B. Glial ephrin-a3 regulates hippocampal dendritic spine morphology and glutamate transport Proceedings of the National Academy of Sciences of the United States of America  2009 106:12524-12529  DOI:10.1073/pnas.0903328106  PMID:19592509  PMCID:PMC2718351
    • Yang, G., Badeanlou, L., Bielawski, J., Roberts, A. J., Hannun, Y. A., Samad, F. Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome American Journal of Physiology-Endocrinology and Metabolism  2009 297:E211-E224  DOI:10.1152/ajpendo.91014.2008  PMID:19435851  PMCID:PMC2711669
    • Trujillo, J. L., Roberts, A. J., Gorman, M. R. Circadian timing of ethanol exposure exerts enduring effects on subsequent ad libitum consumption in c57 mice Alcoholism-Clinical and Experimental Research  2009 33:1286-1293  DOI:10.1111/j.1530-0277.2009.00954.x  PMID:19389184  PMCID:PMC3073399
    • Dugan, L. L., Ali, S. S., Shekhtman, G., Roberts, A. J., Lucero, J., Quick, K. L., Behrens, M. M. IL-6 mediated degeneration of forebrain GABAergic interneurons and cognitive impairment in aged mice through activation of neuronal NADPH oxidase PLoS One  2009 4:e5518  DOI:10.1371/journal.pone.0005518  PMID:19436757  PMCID:PMC2678193
    • Paneda, C., Huitron-Resendiz, S., Frago, L. M., Chowen, J. A., Picetti, R., de Lecea, L., Roberts, A. J. Neuropeptide s reinstates cocaine-seeking behavior and increases locomotor activity through corticotropin-releasing factor receptor 1 in mice Journal of Neuroscience  2009 29:4155-4161  DOI:10.1523/jneurosci.5256-08.2009  PMID:19339610  PMCID:PMC3437665
    • Barros, C. S., Calabrese, B., Chamero, P., Roberts, A. J., Korzus, E., Lloyd, K., Stowers, L., Mayford, M., Halpain, S., Muller, U. Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system Proceedings of the National Academy of Sciences of the United States of America  2009 106:4507-4512  DOI:10.1073/pnas.0900355106  PMID:19240213  PMCID:PMC2657442
    • Wang, J. P., Dunn, A. J., Roberts, A. J., Zhang, H. Decreased immobility in swimming test by homologous interferon-alpha in mice accompanied with increased cerebral tryptophan level and serotonin turnover Neuroscience Letters  2009 452:96-100  DOI:10.1016/j.neulet.2009.01.050  PMID:19383422  PMCID:PMC2680382
    • Kang-Park, M. H., Kieffer, B. L., Roberts, A. J., Roberto, M., Madamba, S. G., Siggins, G. R., Moore, S. D. Mu-opioid receptors selectively regulate basal inhibitory transmission in the central amygdala: Lack of ethanol interactions Journal of Pharmacology and Experimental Therapeutics  2009 328:284-293  DOI:10.1124/jpet.108.140749  PMID:18854491  PMCID:PMC2685907
    • Treweek, J. B., Sun, C., Mayorov, A. V., Qi, L., Levy, C. L., Roberts, A. J., Dickerson, T. J., Janda, K. D. Prevention of drug-induced memory impairment by immunopharmacotherapy Journal of Medicinal Chemistry  2008 51:6866-6875  DOI:10.1021/jm800506v  PMID:18921991  PMCID:PMC2661766
    • Papaleo, F., Ghozland, S., Ingallinesi, M., Roberts, A. J., Koob, G. F., Contarino, A. Disruption of the CRF(2) receptor pathway decreases the somatic expression of opiate withdrawal Neuropsychopharmacology  2008 33:2878-2887  DOI:10.1038/npp.2008.8  PMID:18288089  PMCID:PMC2760329
    • Du, X., Schwander, M., Moresco, E. M. Y., Viviani, P., Haller, C., Hildebrand, M. S., Pak, K., Tarantino, L., Roberts, A., Richardson, H., Koob, G., Najmabadi, H., et al. A catechol-O-methyltransferase that is essential for auditory function in mice and humans Proceedings of the National Academy of Sciences of the United States of America  2008 105:14609-14614  DOI:10.1073/pnas.0807219105  PMID:18794526  PMCID:PMC2567147
    • Li, H., Radford, J. C., Ragusa, M. J., Shea, K. L., McKercher, S. R., Zaremba, J. D., Soussou, W., Nie, Z., Nakanishi, N., Okamoto, S. I., Roberts, A. J., Schwarz, J. J. Transcription factor mef2c influences neural stem/progenitor cell differentiation and maturation in vivo Proceedings of the National Academy of Sciences of the United States of America  2008 105:9397-9402  DOI:10.1073/pnas.0802876105  PMID:18599437  PMCID:PMC2453715
    • Li, Z., McKercher, S. R., Cui, J., Nie, Z. G., Soussou, W., Roberts, A. J., Sallmen, T., Lipton, J. H., Talantova, M., Okamoto, S. I., Lipton, S. A. Myocyte enhancer factor 2C as a neurogenic and antiapoptotic transcription factor in murine embryonic stem cells Journal of Neuroscience  2008 28:6557-6568  DOI:10.1523/jneurosci.0134-08.2008  PMID:18579729  PMCID:PMC2679693
    • Buxbaum, J. N., Ye, Z., Reixach, N., Friske, L., Levy, C., Das, P., Golde, T., Masliah, E., Roberts, A. R., Bartfai, T. Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of a beta toxicity Proceedings of the National Academy of Sciences of the United States of America  2008 105:2681-2686  DOI:10.1073/pnas.0712197105  PMID:18272491  PMCID:PMC2268196
    • Katner, S. N., Von Huben, S. N., Davis, S. A., Lay, C. C., Crean, R. D., Roberts, A. J., Fox, H. S., Taffe, M. A. Robust and stable drinking behavior following long-term oral alcohol intake in rhesus macaques Drug and Alcohol Dependence  2007 91:236-243  DOI:10.1016/j.drugalcdep.2007.06.002  PMID:17628350  PMCID:PMC2231844
    • Finn, D. A., Snelling, C., Fretwell, A. M., Tanchuck, M. A., Underwood, L., Cole, M., Crabbe, J. C., Roberts, A. J. Increased drinking during withdrawal from intermittent ethanol exposure is blocked by the CRF receptor antagonist D-Phe-CRF(12-41) Alcoholism-Clinical and Experimental Research  2007 31:939-949  DOI:10.1111/j.1530-0277.2007.00379.x  PMID:17403068
    • Newton, P. M., Kim, J. A., McGeehan, A. J., Paredes, J. P., Chu, K., Wallace, M. J., Roberts, A. J., Hodge, C. W., Messing, R. O. Increased response to morphine in mice lacking protein kinase c epsilon Genes Brain and Behavior  2007 6:329-338  DOI:10.1111/j.1601-183X.2006.00261.x  PMID:16899053  PMCID:PMC4264050
    • Prut, L., Abramowski, D., Krucker, T., Levy, C. L., Roberts, A. J., Staufenbiel, M., Wiessner, C. Aged app23 mice show a delay in switching to the use of a strategy in the barnes maze Behavioural Brain Research  2007 179:107-110  DOI:10.1016/j.bbr.2007.01.017  PMID:17324476
    • Chu, K., Koob, G. F., Cole, M., Zorrilla, E. P., Roberts, A. J. Dependence-induced increases in ethanol self-administration in mice are blocked by the crf, receptor antagonist antalarmin and by crf, receptor knockout Pharmacology, Biochemistry and Behavior  2007 86:813-821  DOI:10.1016/j.pbb.2007.03.009  PMID:17482248  PMCID:PMC2170886
    • Kang-Park, M. H., Kieffer, B. L., Roberts, A. J., Siggins, G. R., Moore, S. D. Presynaptic delta opioid receptors regulate ethanol actions in central amygdala Journal of Pharmacology and Experimental Therapeutics  2007 320:917-925  DOI:10.1124/jpet.106.112722  PMID:17114568
    • Metten, P., Buck, K. J., Merrill, C. M., Roberts, A. J., Yu, C. H., Crabbe, J. C. Use of a novel mouse genotype to model acute benzodiazepine withdrawal Behavior Genetics  2007 37:160-170  DOI:10.1007/s10519-006-9094-3  PMID:17226103
    • Kunz, S., Rojek, J. M., Roberts, A. J., McGavern, D. B., Oldstone, M. B. A., de la Torre, J. C. Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus Journal of Virology  2006 80:9082-9092  DOI:10.1128/jvi.00795-06  PMID:16940520
    • Chen, A., Zorrilla, E., Smith, S., Rousso, D., Levy, C., Vaughan, J., Donaldson, C., Roberts, A., Lee, K. F., Vale, W. Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior Journal of Neuroscience  2006 26:5500-5510  DOI:10.1523/jneurosci.3955-05.2006  PMID:16707802
    • Tabarin, A., Chaves, Y. D., Carmona, M. D., Catargi, B., Zorrilla, E. P., Roberts, A. J., Coscina, D. V., Rousset, S., Redonnet, A., Parker, G. C., Inoue, K., Ricquier, D., et al. Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: Evidence for a "thrifty gene" Diabetes  2005 54:3510-3516  DOI:10.2337/diabetes.54.12.3510  PMID:16306369
    • Tallent, M. K., Veronique, F., Qiu, C., Calbet, M., Lamp, T., Baratta, M. V., Suzuki, C., Levy, C. L., Siggins, G. R., Henriksen, S. J., Criado, J. R., Roberts, A., et al. Cortistatin overexpression in transgenic mice produces deficits in synaptic plasticity and learning Molecular and Cellular Neuroscience  2005 30:465-475  DOI:10.1016/j.mcn.2005.08.010  PMID:16182561
    • Ghozland, S., Chu, K., Kieffer, B. L., Roberts, A. J. Lack of stimulant and anxiolytic-like effects of ethanol and accelerated development of ethanol dependence in mu-opioid receptor knockout mice Neuropharmacology  2005 49:493-501  DOI:10.1016/j.neuropharm.2005.04.006  PMID:15961126
    • Carrera, M. R. A., Trigo, J. M., Wirsching, P., Roberts, A. J., Janda, K. D. Evaluation of the anticocaine monoclonal antibody GNC92H2 as an immunotherapy for cocaine overdose Pharmacology, Biochemistry and Behavior  2005 81:709-714  DOI:10.1016/j.pbb.2005.04.018  PMID:16005948
    • Sanchis-Segura, C., Grisel, J. E., Olive, M. F., Ghozland, S., Koob, G. F., Roberts, A. J., Cowen, M. S. Role of the endogenous opioid system on the neuropsychopharmacological effects of ethanol: New insights about an old question Alcoholism-Clinical and Experimental Research  2005 29:1522-1527  DOI:10.1097/01.alc.0000174913.60384.e8  PMID:16156049
    • Breese, G. R., Chu, K., Dayas, C. V., Funk, D., Knapp, D. J., Koob, G. F., Le, D. A., O'Dell, L. E., Overstreet, D. H., Roberts, A. J., Sinha, R., Valdez, G. R., et al. Stress enhancement of craving during sobriety: A risk for relapse Alcoholism-Clinical and Experimental Research  2005 29:185-195  DOI:10.1097/01.alc.0000153544.83656.3c  PMID:15714042
    • Winsky-Sommerer, R., Yamanaka, A., Diano, S., Borok, E., Roberts, A. J., Sakurai, T., Kilduff, T. S., Horvath, T. L., de Lecea, L. Interaction between the corticotropin-releasing factor system and hypocretins (orexins): A novel circuit mediating stress response Journal of Neuroscience  2004 24:11439-11448  DOI:10.1523/jneurosci.3459-04.2004  PMID:15601950
    • O'Dell, L. E., Roberts, A. J., Smith, R. T., Koob, G. F. Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure Alcoholism-Clinical and Experimental Research  2004 28:1676-1682  DOI:10.1097/01.alc.0000145781.11923.4e  PMID:15547454
    • Risbrough, V. B., Hauger, R. L., Roberts, A. L., Vale, W. W., Geyer, M. A. Corticotropin-releasing factor receptors CRF1 and CRF2 exert both additive and opposing influences on defensive startle behavior Journal of Neuroscience  2004 24:6545-6552  DOI:10.1523/jneurosci.5760-03.2004  PMID:15269266
    • Katner, S. N., Flynn, C. T., Von Huben, S. N., Kirsten, A. J., Davis, S. A., Lay, C. C., Cole, M., Roberts, A. J., Fox, H. S., Taffe, M. A. Controlled and behaviorally relevant levels of oral ethanol intake in rhesus macaques using a flavorant-fade procedure Alcoholism-Clinical and Experimental Research  2004 28:873-883  DOI:10.1097/01.alc.0000128895.99379.8c  PMID:15201630
    • Roberts, A. J., Krucker, T., Levy, C. L., Slanina, K. A., Sutcliffe, J. G., Hedlund, P. B. Mice lacking 5-ht7 receptors show specific impairments in contextual learning European Journal of Neuroscience  2004 19:1913-1922  DOI:10.1111/j.1460.9568.2004.03288.x  PMID:15078565
    • Nie, Z. G., Schweitzer, P., Roberts, A. J., Madamba, S. G., Moore, S. D., Siggins, G. R. Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors Science  2004 303:1512-1514  DOI:10.1126/science.1092550  PMID:15001778
    • Finn, D. A., Roberts, A. J., Long, S., Tanchuck, M., Phillips, T. J. Neurosteroid consumption has anxiolytic effects in mice Pharmacology, Biochemistry and Behavior  2003 76:451-462  DOI:10.1016/j.pbb.2003.09.004  PMID:14643844
    • Bale, T. L., Anderson, K. R., Roberts, A. J., Lee, K. F., Nagy, T. R., Vale, W. W. Corticotropin-releasing factor receptor-2-deficient mice display abnormal homeostatic responses to challenges of increased dietary fat and cold Endocrinology  2003 144:2580-2587  DOI:10.1210/en.2002-0091  PMID:12746321
    • Valdez, G. R., Zorrilla, E. P., Roberts, A. J., Koob, G. F. Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence Alcohol  2003 29:55-60  DOI:10.1016/s0741-8329(03)00020-x  PMID:12782246
    • Koob, G. F., Roberts, A. J., Kieffer, B. L., Heyser, C. J., Katner, S. N., Ciccocioppo, R., Weiss, F. Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology Recent Developments in Alcoholism  2003 16:263-281  DOI:10.1007/0-306-47939-7_19  PMID:12638642
    • Valdez, G. R., Roberts, A. J., Chan, K., Davis, H., Brennan, M., Zorrilla, E. P., Koob, G. F. Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: Regulation by corticotropin-releasing factor Alcoholism-Clinical and Experimental Research  2002 26:1494-1501  DOI:10.1097/01.alc.0000033120.51856.f0  PMID:12394282
    • Ryabinin, A. E., Bachtell, R. K., Heinrichs, S. C., Lee, S., Rivier, C., Olive, M. F., Mehmert, K. K., Camarini, R., Kim, J. A., Koenig, H. N., Nannini, M. A., Hodge, C. W., et al. The corticotropin-releasing factor/urocortin system and alcohol Alcoholism-Clinical and Experimental Research  2002 26:714-722  DOI:10.1111/j.1530-0277.2002.tb02596.x  PMID:12045481
    • Roberts, A. J., Gold, L. H., Polis, L., McDonald, J. S., Filliol, D., Kieffer, B. L., Koob, G. F. Increased ethanol self-administration in delta-opioid receptor knockout mice Alcoholism-Clinical and Experimental Research  2001 25:1249-1256  DOI:10.1111/j.1530-0277.2001.tb02344.x  PMID:11584142
    • Le, A. D., Kiianmaa, K., Cunningham, C. L., Engel, J. A., Ericson, M., Soderpalm, B., Koob, G. F., Roberts, A. J., Weiss, F., Hyytia, P., Janhunen, S., Mikkola, J., et al. Neurobiological processes in alcohol addiction Alcoholism-Clinical and Experimental Research  2001 25:144S-151S  DOI:10.1111/j.1530-0277.2001.tb02389.x  PMID:11391064
    • Flannery, B. A., Roberts, A. J., Cooney, N., Swift, R. M., Anton, R. F., Rohsenow, D. J. The role of craving in alcohol use, dependence, and treatment Alcoholism-Clinical and Experimental Research  2001 25:299-308  DOI:10.1111/j.1530-0277.2001.tb02213.x  PMID:11236847
    • Koob, G., Bartfai, T., Roberts, A. J. Molecular genetic approaches to the neuropharmacology of corticotropin releasing factor International Journal of Comparative Psychology  2001 14:90-110
    • Roberts, A. J., Heyser, C. J., Cole, M., Griffin, P., Koob, G. F. Excessive ethanol drinking following a history of dependence: Animal model of allostasis Neuropsychopharmacology  2000 22:581-594  DOI:10.1016/s0893-133x(99)00167-0  PMID:10788
    • Roberts, A. J., McDonald, J. S., Heyser, C. J., Kieffer, B. L., Matthes, H. W. D., Koob, G. F., Gold, L. H. Mu-opioid receptor knockout mice do not self-administer alcohol Journal of Pharmacology and Experimental Therapeutics  2000 293:1002-1008  PMID:10869404
    • Roberts, A., Heyser, C., Koob, G. Blood alcohol concentrations in rats drinking or intubated with ethanol. Response Alcoholism-Clinical and Experimental Research  1999 23:1946-1947  DOI:10.1111/j.1530-0277.1999.tb04098.x  PMID:10630615
    • Heyser, C. J., Roberts, A. J., Schulteis, G., Koob, G. F. Central administration of an opiate antagonist decreases oral ethanol self-administration in rats Alcoholism-Clinical and Experimental Research  1999 23:1468-1476  DOI:10.1097/00000374-199909000-00008  PMID:10512312
    • Roberts, A. J., Heyser, C. J., Koob, G. F. Operant self-administration of sweetened versus unsweetened ethanol: effects on blood alcohol levels Alcoholism-Clinical and Experimental Research  1999 23:1151-1157  DOI:10.1097/00000374-199907000-00003  PMID:10443980
    • Koob, G. F., Roberts, A. J. Brain reward circuits in alcoholism CNS Spectrums  1999 4:23-37
    • Rodrigquez De Fonseca, F., Roberts, A. J., Bilbao, A., Koob, G. F., Navarro, M. Cannabinoid receptor antagonist SR141716a decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers Acta Pharmacologica Sinica  1999 20:1109-1114  PMID:11189201
    • Navarro, M., Chowen, J., Carrera, M. R. A., del Arco, I., Villanua, M. A., Martin, Y., Roberts, A. J., Koob, G. F., de Fonseca, F. R. Cb1 cannabinoid receptor antagonist-induced opiate withdrawal in morphine-dependent rats Neuroreport  1998 9:3397-3402  DOI:10.1097/00001756-199810260-00012  PMID:9855288
    • Roberts, A. J., Smith, A. D., Weiss, F., Rivier, C., Koob, G. F. Estrous cycle effects on operant responding for ethanol in female rats Alcoholism-Clinical and Experimental Research  1998 22:1564-1569  DOI:10.1097/00000374-199810000-00028  PMID:9802543
    • Roberts, A. J., McArthur, R. A., Hull, E. E., Post, C., Koob, G. F. Effects of amperozide, 8-OH-DPAT, and FG 5974 on operant responding for ethanol Psychopharmacology  1998 137:25-32  DOI:10.1007/s002130050589  PMID:9631953
    • Koob, G. F., Rocio, M., Carrera, A., Gold, L. H., Heyser, C. J., Maldonado-Irizarry, C., Markou, A., Parsons, L. H., Roberts, A. J., Schulteis, G., Stinus, L., Walker, J. R., et al. Substance dependence as a compulsive behavior Journal of Psychopharmacology  1998 12:39-48  DOI:10.1177/026988119801200106  PMID:9584967
    • Koob, G. F., Roberts, A. J., Schulteis, G., Parsons, L. H., Heyser, C. J., Hyytia, P., Merlo-Pich, E., Weiss, F. Neurocircuitry targets in ethanol reward and dependence Alcoholism-Clinical and Experimental Research  1998 22:3-9  DOI:10.1097/00000374-199802000-00001  PMID:9514280
    • Phillips, T. J., Roberts, A. J., Lessov, C. N. Behavioral sensitization to ethanol: Genetics and the effects of stress Pharmacology, Biochemistry and Behavior  1997 57:487-493  DOI:10.1016/s0091-3057(96)00448-0  PMID:9218273
    • Roberts, A. J., Polis, I. Y., Gold, L. H. Intravenous self-administration of heroin, cocaine, and the combination in balb/c mice European Journal of Pharmacology  1997 326:119-125  DOI:10.1016/s0014-2999(97)85405-2  PMID:9196263
    • Finn, D. A., Roberts, A. J., Lotrich, F., Gallaher, E. J. Genetic differences in behavioral sensitivity to a neuroactive steroid Journal of Pharmacology and Experimental Therapeutics  1997 280:820-828  PMID:9023296
    • Roberts, A. J., Koob, G. F. The neurobiology of addiction: an overview Alcohol Health and Research World  1997 21:101-106  PMID:15704343
    • Roberts, A. J., Cole, M., Koob, G. F. Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats Alcoholism-Clinical and Experimental Research  1996 20:1289-1298  DOI:10.1111/j.1530-0277.1996.tb01125.x  PMID:8904984
    • Gold, L. H., Heyser, C. J., Roberts, A. J., Henriksen, S. J., Steffensen, S. C., Siggins, G. R., Bellinger, F. P., Chiang, C. S., Powell, H. C., Masliah, E., Campbell, I. L. Behavioral and neurophysiological effects of CNS expression of cytokines in transgenic mice Advances in Experimental Medicine and Biology  1996 402:199-205  DOI:10.1007/978-1-4613-0407-4_26  PMID:8787661
    • Roberts, A. J., Phillips, T. J., Belknap, J. K., Finn, D. A., Keith, L. D. Genetic analysis of the corticosterone response to ethanol in bxd recombinant inbred mice Behavioral Neuroscience  1995 109:1199-1208  DOI:10.1037//0735-7044.109.6.1199  PMID:8748968
    • Roberts, A. J., Lessov, C. N., Phillips, T. J. Critical role for glucocorticoid receptors in stress-induced and ethanol-induced locomotor sensitization Journal of Pharmacology and Experimental Therapeutics  1995 275:790-797  PMID:7473168
    • Finn, D. A., Roberts, A. J., Crabbe, J. C. Neuroactive steroid sensitivity in withdrawal seizure-prone and -resistant mice Alcoholism-Clinical and Experimental Research  1995 19:410-415  DOI:10.1111/j.1530-0277.1995.tb01523.x  PMID:7625575
    • Roberts, A. J., Keith, L. D. Corticosteroids enhance convulsion susceptibility via central mineralocorticoid receptors Psychoneuroendocrinology  1995 20:891-902  DOI:10.1016/0306-4530(95)00016-x  PMID:88340
    • Roberts, A. J., Keith, L. D. Sensitivity of the circadian-rhythm of kainic acid-induced convulsion susceptibility to manipulations of corticosterone levels and mineralocorticoid receptor-binding Neuropharmacology  1994 33:1087-1093  DOI:10.1016/0028-3908(94)90147-3  PMID:7838321
    • Roberts, A. J., Keith, L. D. Mineralocorticoid receptors mediate the enhancing effects of corticosterone on convulsion susceptibility in mice Journal of Pharmacology and Experimental Therapeutics  1994 270:505-511  PMID:8071844
    • Roberts, A. J., Crabbe, J. C., Keith, L. D. Corticosterone increases severity of acute withdrawal from ethanol, pentobarbital, and diazepam in mice Psychopharmacology  1994 115:278-284  DOI:10.1007/bf02244784  PMID:7862907
    • Roberts, A. J., Crabbe, J. C., Keith, L. D. Type I corticosteroid receptors modulate PTZ-induced convulsions of withdrawal seizure prone mice Brain Research  1993 626:143-148  DOI:10.1016/0006-8993(93)90573-6  PMID:8281425
    • Roberts, A. J., Gallaher, E. J., Keith, L. D. Dissociation of the effect of aminoglutethimide on corticosterone biosynthesis from ataxic and hypothermic effects in DBA and C57 mice Neuroendocrinology  1993 58:303-309  DOI:10.1159/000126554  PMID:8255391
    • Roberts, A. J., Crabbe, J. C., Keith, L. D. Genetic differences in hypothalamic-pituitary-adrenal axis responsiveness to acute ethanol and acute ethanol withdrawal Brain Research  1992 579:296-302  DOI:10.1016/0006-8993(92)90064-g  PMID:1320985
    • Roberts, A. J., Chu, H. P., Crabbe, J. C., Keith, L. D. Differential modulation by the stress axis of ethanol withdrawal seizure expression in WSP and WSR mice Alcoholism-Clinical and Experimental Research  1991 15:412-417  DOI:10.1111/j.1530-0277.1991.tb00539.x  PMID:1652218
  • thesis

    • Type I receptors mediate the enhancing effects of corticosterone upon convulsion susceptibility in mice 1993
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Research

research overview

  • Mouse Behavioral Assessment Core. 

    The Mouse Behavioral Assessment Core is a state-of-the-art behavioral phenotyping facility. It provides a centralized resource for standard behavioral assays (anxiety-like, cognitive, motor, sensory gating, etc.), drug abuse/dependence models (selfadministration, place conditioning), metabolic studies (CLAMS, EchoMRI), electroencephalography (power spectra analyses, sleep, seizures), surgical procedures and target compound assessments. We provide as a fee-for-service: 
    1) High quality behavioral testing relevant to neurodegenerative, neurological and psychiatric disorders 
    2) Phenotyping services for novel transgenic mouse lines 
    3) A resource for behavioral experimental design assistance, animal protocol (IACUC) preparation, data analysis, and results interpretation 
    4) Training for investigators, post-docs, and students in behavioral techniques. 

    Mouse Target Assessment Core. 

    We are currently funded to run the Mouse Target Assessment Core as part of the Integrative Neurosciences Initiative on Alcoholism-West (INIA-West). We are using a mouse model of excessive alcohol drinking that involves assessing voluntary intake before and after chronic intermittent ethanol vapor exposure. In this model, ethanol drinking following the vapor exposure is elevated by 50-100% relative to non-vapor control mice and blood alcohol levels achieved by this increased drinking exceed 100 mg%. The overall theoretical structure is that a combination of animal models, neurobiological targets derived from such models and the availability of target compounds provides a framework for the development of pharmacotherapeutics for alcohol abuse and dependence. Genes associated with excessive ethanol consumption have been compiled and a thorough discussion of this list in our biannual INIA-West meetings has led to the identification of several pathways of potentially compelling importance. Currently, neuroinflammatory system targets such as TLR4, PPAR, IKK beta, and Pde 4 are being explored.
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Background

education and training

  • Ph.D. in Behavioral Neuroscience, Oregon Health & Science University 1993
  • M.S. in Behavioral Neuroscience, Oregon Health & Science University 1990
  • B.A. in Psychobiology, University of California, Santa Cruz 1988
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Contact

full name

  • Amanda J. Roberts

geographic location

  • Scripps California 

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