recent publications
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academic article
- Patel, R. R., Khom, S., Steinman, M. Q., Varodayan, F. P., Kiosses, W. B., Hedges, D. M., Vlkolinsky, R., Nadav, T., Polis, I., Bajo, M., Roberts, A. J., Roberto, M. IL-1β expression is increased and regulates GABA transmission following chronic ethanol in mouse central amygdala Brain Behavior and Immunity 2019 75:208-219 DOI:10.1016/j.bbi.2018.10.009
- Pinto-Duarte, A., Roberts, A. J., Ouyang, K. F., Sejnowski, T. J. Impairments in remote memory caused by the lack of Type 2 IP3 receptors Glia 2019 67:1976-1989 DOI:10.1002/glia.23679 PMID:31348567
- Roberts, A. J., Khom, S., Bajo, M., Vlkolinsky, R., Polis, I., Cates-Gatto, C., Roberto, M., Gruol, D. L. Increased IL-6 expression in astrocytes is associated with emotionality, alterations in central amygdala GABAergic transmission, and excitability during alcohol withdrawal Brain Behavior and Immunity 2019 82:188-202 DOI:10.1016/j.bbi.2019.08.185 PMID:31437534 PMCID:PMC6800653
- Blednov, Y. A., Bajo, M., Roberts, A. J., Da Costa, A. J., Black, M., Edmunds, S., Mayfield, J., Roberto, M., Homanics, G. E., Lasek, A. W., Hitzemann, R. J., Harris, R. A. Scn4b regulates the hypnotic effects of ethanol and other sedative drugs Genes Brain and Behavior 2019 18 DOI:10.1111/gbb.12562 PMID:30817077 PMCID:PMC6612599
- Huang, L., Shum, E. Y., Jones, S. H., Lou, C. H., Dumdie, J., Kim, H., Roberts, A. J., Jolly, L. A., Espinoza, J. L., Skarbrevik, D. M., Phan, M. H., Cook-Andersen, H., et al. A Upf3b-mutant mouse model with behavioral and neurogenesis defects Molecular Psychiatry 2018 23:1773-1786 DOI:10.1038/mp.2017.173 PMID:28948974 PMCID:PMC5869067
- Long, J. Z., Roche, A. M., Berdan, C. A., Louie, S. M., Roberts, A. J., Svensson, K. J., Dou, F. Y., Bateman, L. A., Mina, A. I., Deng, Z. M., Jedrychowski, M. P., Lin, H., et al. Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociception Proceedings of the National Academy of Sciences of the United States of America 2018 115:E6937-E6945 DOI:10.1073/pnas.1803389115 PMID:29967167 PMCID:PMC6055169
- Gruol, D. L., Huitron-Resendiz, S., Roberts, A. J. Altered brain activity during withdrawal from chronic alcohol is associated with changes in IL-6 signal transduction and GABAergic mechanisms in transgenic mice with increased astrocyte expression of IL-6 Neuropharmacology 2018 138:32-46 DOI:10.1016/j.neuropharm.2018.05.024 PMID:29787738
- Bray, J. G., Reyes, K. C., Roberts, A. J., Gruol, D. L. Altered hippocampal synaptic function in transgenic mice with increased astrocyte expression of CCL2 after withdrawal from chronic alcohol Neuropharmacology 2018 135:113-125 DOI:10.1016/j.neuropharm.2018.02.031 PMID:29499275 PMCID:PMC5975123
- Song, T., Liang, S., Liu, J., Zhang, T., Yin, Y., Geng, C., Gao, S., Feng, Y., Xu, H., Guo, D., Roberts, A., Gu, Y., et al. CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory PLoS Genetics 2018 14 DOI:10.1371/journal.pgen.1007165 PMID:29370161
- Huitron-Resendiz, S., Nadav, T., Krause, S., Cates-Gatto, C., Polis, I., Roberts, A. J. Effects of withdrawal from chronic intermittent ethanol exposure on sleep characteristics of female and male mice Alcoholism-Clinical and Experimental Research 2018 42:540-550 DOI:10.1111/acer.13584 PMID:29265376 PMCID:PMC5832570
- Courchet, V., Roberts, A. J., Meyer-Dilhet, G., Del Carmine, P., Lewis, T. L., Polleux, F., Courchet, J. Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice Nature Communications 2018 9 DOI:10.1038/s41467-018-06584-5 PMID:30327473 PMCID:PMC6191442
- Roberts, A. J., Casal, L., Huitron-Resendiz, S., Thompson, T., Tarantino, L. M. Intravenous cocaine self-administration in a panel of inbred mouse strains differing in acute locomotor sensitivity to cocaine Psychopharmacology 2018 235:1179-1189 DOI:10.1007/s00213-018-4834-7 PMID:29423710 PMCID:PMC5874174
- Ogasawara, D., Ichu, T. A., Vartabedian, V. F., Benthuysen, J., Jing, H., Reed, A., Ulanovskaya, O. A., Hulce, J. J., Roberts, A., Brown, S., Rosen, H., Teijaro, J. R., et al. Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo Nature Chemical Biology 2018 14:1099-1108 DOI:10.1038/s41589-018-0155-8 PMID:30420694 PMCID:PMC6263940
- Harris, R. A., Bajo, M., Bell, R. L., Blednov, Y. A., Varodayan, F. P., Truitt, J. M., de Guglielmo, G., Lasek, A. W., Logrip, M. L., Vendruscolo, L. F. Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents Journal of Neuroscience 2017 37:1139-1155 DOI:10.1523/jneurosci.2002-16.2016 PMID:27986929 PMCID:PMC5296793
- Juarez, B., Morel, C., Ku, S. M., Liu, Y., Zhang, H., Montgomery, S., Gregoire, H., Ribeiro, E., Crumiller, M., Roman-Ortiz, C., Walsh, J. J., Jackson, K., et al. Midbrain circuit regulation of individual alcohol drinking behaviors in mice Nature Communications 2017 8 DOI:10.1038/s41467-017-02365-8 PMID:29263389 PMCID:PMC5738419
- Tu, S., Akhtar, M. W., Escorihuela, R. M., Amador-Arjona, A., Swarup, V., Parker, J., Zaremba, J. D., Holland, T., Bansal, N., Holohan, D. R., Lopez, K., Ryan, S. D., et al. NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism Nature Communications 2017 8 DOI:10.1038/s41467-017-01563-8 PMID:29133852 PMCID:PMC5684358
- Sanna, P. P., Kawamura, T., Chen, J., Koob, G. F., Roberts, A. J., Vendruscolo, L. F., Repunte-Canonigo, V. 11β-hydroxysteroid dehydrogenase inhibition as a new potential therapeutic target for alcohol abuse Translational Psychiatry 2016 6 DOI:10.1038/tp.2016.13 PMID:26978742 PMCID:PMC4872439
- Schweitzer, P., Cates-Gatto, C., Varodayan, F. P., Nadav, T., Roberto, M., Lasek, A. W., Roberts, A. J. Dependence-induced ethanol drinking and GABA neurotransmission are altered in Alk deficient mice Neuropharmacology 2016 107:1-8 DOI:10.1016/j.neuropharm.2016.03.003 PMID:26946429 PMCID:PMC4912883
- Bajo, M., Montgomery, S. E., Cates, L. N., Nadav, T., Delucchi, A. M., Cheng, K., Yin, H., Crawford, E. F., Roberts, A. J., Roberto, M. Evaluation of TLR4 inhibitor, T5342126, in modulation of ethanol-drinking behavior in alcohol-dependent mice Alcohol and Alcoholism 2016 51:541-548 DOI:10.1093/alcalc/agw026 PMID:27151970 PMCID:PMC5004745
- Huitron-Resendiz, S., Roberts, A. J., Kamenecka, T. M., Solt, L. A., Burris, T. P. Pharmacological targeting the REV-ERBs in sleep/wake regulation PLoS One 2016 11 DOI:10.1371/journal.pone.0162452 PMID:27603791 PMCID:PMC5014418
- Prior, M., Goldberg, J., Chiruta, C., Farrokhi, C., Kopynets, M., Roberts, A. J., Schubert, D. Selecting for neurogenic potential as an alternative for Alzheimer's disease drug discovery Alzheimers & Dementia 2016 12:678-686 DOI:10.1016/j.jalz.2016.03.016 PMID:27149904
- Zhou, B., Eubanks, L. M., Jacob, N. T., Ellis, B., Roberts, A. J., Janda, K. D. Studies towards the improvement of an anti-cocaine monoclonal antibody for treatment of acute overdose Bioorganic & Medicinal Chemistry Letters 2016 26:5078-5081 DOI:10.1016/j.bmcl.2016.08.081 PMID:27599743 PMCID:PMC5050165
- Hernandez, R. V., Puro, A. C., Manos, J. C., Huitron-Resendiz, S., Reyes, K. C., Liu, K., Vo, K., Roberts, A. J., Gruol, D. L. Transgenic mice with increased astrocyte expression of IL-6 show altered effects of acute ethanol on synaptic function Neuropharmacology 2016 103:27-43 DOI:10.1016/j.neuropharm.2015.12.015 PMID:26707655 PMCID:PMC4755829
- Kreifeldt, M., Cates-Gatto, C., Roberts, A. J., Contet, C. BK channel β1 subunit contributes to behavioral adaptations elicited by chronic intermittent ethanol exposure Alcoholism-Clinical and Experimental Research 2015 39:2394 DOI:10.1111/acer.12911 PMID:26578345 PMCID:PMC4712106
- Jackson, E., Demarest, K., Eckert, W. J., Cates-Gatto, C., Nadav, T., Cates, L. N., Howard, H., Roberts, A. J. Aspen shaving versus chip bedding: effects on breeding and behavior Laboratory Animals 2015 49:46-56 DOI:10.1177/0023677214553320 PMID:25260358
- Hoefer, M. M., Sanchez, A. B., Maung, R., de Rozieres, C. M., Catalan, I. C., Dowling, C. C., Thaney, V. E., Pina-Crespo, J., Zhang, D., Roberts, A. J., Kaul, M. Combination of methamphetamine and HIV-1 gp120 causes distinct long-term alterations of behavior, gene expression, and injury in the central nervous system Experimental Neurology 2015 263:221-234 DOI:10.1016/j.expneurol.2014.09.010 PMID:25246228 PMCID:PMC4370186
- Kurczy, M. E., Zhu, Z. J., Ivanisevic, J., Schuyler, A. M., Lalwani, K., Santidrian, A. F., David, J. M., Giddabasappa, A., Roberts, A. J., Olivos, H. J., O'Brien, P. J., Franco, L., et al. Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids Nature Communications 2015 6:5998 DOI:10.1038/ncomms6998 PMID:25601659 PMCID:PMC4454288
- Herman, M. A., Sidhu, H., Stouffer, D. G., Kreifeldt, M., Le, D., Cates-Gatto, C., Munoz, M. B., Roberts, A. J., Parsons, L. H., Roberto, M., Wickman, K., Slesinger, P. A., et al. GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol Proceedings of the National Academy of Sciences of the United States of America 2015 112:7091-7096 DOI:10.1073/pnas.1416146112 PMID:25964320 PMCID:PMC4460485
- Bajo, M., Varodayan, F. P., Madamba, S. G., Roberts, A. J., Casal, L. M., Oleata, C. S., Siggins, G. R., Roberto, M. IL-1 interacts with ethanol effects on GABAergic transmission in the mouse central amygdala Frontiers in Pharmacology 2015 6:49 DOI:10.3389/fphar.2015.00049 PMID:25852553 PMCID:PMC4365713
- Kang-Park, M., Kieffer, B. L., Roberts, A. J., Siggins, G. R., Moore, S. D. Interaction of CRF and kappa opioid systems on GABAergic neurotransmission in the mouse central amygdala Journal of Pharmacology and Experimental Therapeutics 2015 355:206-211 DOI:10.1124/jpet.115.225870 PMID:26350161 PMCID:PMC4613963
- Hauser, S. R., Hedlund, P. B., Roberts, A. J., Sari, Y., Bell, R. L., Engleman, E. A. The 5-HT7 receptor as a potential target for treating drug and alcohol abuse Frontiers in Neuroscience 2015 8:448-448 DOI:10.3389/fnins.2014.00448 PMID:25628528 PMCID:PMC4292232
- Lee, H. S., Ghetti, A., Pinto-Duarte, A., Wang, X., Dziewczapolski, G., Galimi, F., Huitron-Resendiz, S., Pina-Crespo, J. C., Roberts, A. J., Verma, I. M., Sejnowski, T. J., Heinemann, S. F. Astrocytes contribute to gamma oscillations and recognition memory Proceedings of the National Academy of Sciences of the United States of America 2014 111:E3343-E3352 DOI:10.1073/pnas.1410893111 PMID:25071179 PMCID:PMC4136580
- Maung, R., Hoefer, M. M., Sanchez, A. B., Sejbuk, N. E., Medders, K. E., Desai, M. K., Catalan, I. C., Dowling, C. C., de Rozieres, C. M., Garden, G. A., Russo, R., Roberts, A. J., et al. CCR5 knockout prevents neuronal injury and behavioral impairment induced in a transgenic mouse model by a CXCR4-using HIV-1 glycoprotein 120 Journal of Immunology 2014 193:1895-1910 DOI:10.4049/jimmunol.1302915 PMID:25031461 PMCID:PMC4370188
- Repunte-Canonigo, V., Chen, J., Lefebvre, C., Kawamura, T., Kreifeldt, M., Basson, O., Roberts, A. J., Sanna, P. P. MeCP2 regulates ethanol sensitivity and intake Addiction Biology 2014 19:791-799 DOI:10.1111/adb.12047 PMID:23448145 PMCID:PMC3692583
- Vendruscolo, L. F., Roberts, A. J. Operant alcohol self-administration in dependent rats: focus on the vapor model Alcohol 2014 48:277-286 DOI:10.1016/j.alcohol.2013.08.006 PMID:24290310 PMCID:PMC4007394
- Banerjee, S., Wang, Y., Solt, L. A., Griffett, K., Kazantzis, M., Amador, A., El-Gendy, B. M., Huitron-Resendiz, S., Roberts, A. J., Shin, Y., Kamenecka, T. M., Burris, T. P. Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour Nature Communications 2014 5:5759 DOI:10.1038/ncomms6759 PMID:25536025 PMCID:PMC4495958
- Zorrilla, E. P., Roberts, A. J., Rivier, J. E., Koob, G. F. Anxiolytic-Like Effects of Antisauvagine-30 in Mice Are Not Mediated by CRF2 Receptors PLoS One 2013 8:e63942 DOI:10.1371/journal.pone.0063942 PMID:24015170 PMCID:PMC3756045
- Talantova, M., Sanz-Blasco, S., Zhang, X. F., Xia, P., Akhtar, M. W., Okamoto, S., Dziewczapolski, G., Nakamura, T., Cao, G., Pratt, A. E., Kang, Y. J., Tu, S., et al. Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss Proceedings of the National Academy of Sciences of the United States of America 2013 110:E2518-E2527 DOI:10.1073/pnas.1306832110 PMID:23776240 PMCID:PMC3704025
- Eisener-Dorman, A. F., Bailey, J. S., Grabowski-Boase, L., Huitron-Resendiz, S., Roberts, A. J., Wiltshire, T., Tarantino, L. M. Characterization of highper, an enu-induced mouse mutant with abnormal psychostimulant and stress responses Psychopharmacology 2013 225:407-419 DOI:10.1007/s00213-012-2827-5 PMID:22948668 PMCID:PMC3536991
- Li, X., Risbrough, V. B., Cates-Gatto, C., Kaczanowska, K., Finn, M. G., Roberts, A. J., Markou, A. Comparison of the effects of the GABA(B) receptor positive modulator BHF177 and the GABA(B) receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice Neuropharmacology 2013 70:156-167 DOI:10.1016/j.neuropharm.2013.01.018 PMID:23376712 PMCID:PMC3644349
- Cates, L. N., Roberts, A. J., Huitron-Resendiz, S., Hedlund, P. B. Effects of lurasidone in behavioral models of depression. Role of the 5-HT7 receptor subtype Neuropharmacology 2013 70:211-217 DOI:10.1016/j.neuropharm.2013.01.023 PMID:23416039
- Kang-Park, M., Kieffer, B. L., Roberts, A. J., Siggins, G. R., Moore, S. D. Kappa-opioid receptors in the central amygdala regulate ethanol actions at presynaptic GABAergic sites Journal of Pharmacology and Experimental Therapeutics 2013 346:130-137 DOI:10.1124/jpet.112.202903 PMID:23587526 PMCID:PMC3684840
- Gorini, G., Roberts, A. J., Mayfield, R. D. Neurobiological signatures of alcohol dependence revealed by protein profiling PLoS One 2013 8:e82656 DOI:10.1371/journal.pone.0082656 PMID:24358215 PMCID:PMC3865151
- Bray, J. G., Reyes, K. C., Roberts, A. J., Ransohoff, R. M., Gruol, D. L. Synaptic plasticity in the hippocampus shows resistance to acute ethanol exposure in transgenic mice with astrocyte-targeted enhanced CCL2 expression Neuropharmacology 2013 67:115-125 DOI:10.1016/j.neuropharm.2012.11.007 PMID:23164616 PMCID:PMC3595200
- Chang, Y., She, Z. G., Sakimura, K., Roberts, A., Kucharova, K., Rowitch, D. H., Stallcup, W. B. Ablation of NG2 proteoglycan leads to deficits in brown fat function and to adult onset obesity PLoS One 2012 7:e30637 DOI:10.1371/journal.pone.0030637 PMID:22295099 PMCID:PMC3266271
- Semenova, S., Contet, C., Roberts, A. J., Markou, A. Mice lacking the beta4 subunit of the nicotinic acetylcholine receptor show memory deficits, altered anxiety- and depression-like behavior, and diminished nicotine-induced analgesia Nicotine & Tobacco Research 2012 14:1346-1355 DOI:10.1093/ntr/nts107 PMID:22573727 PMCID:PMC3482014
- Roberts, A. J., Hedlund, P. B. The 5-HT(7) receptor in learning and memory Hippocampus 2012 22:762-771 DOI:10.1002/hipo.20938 PMID:21484935 PMCID:PMC3310936
- Chen, Q., Prior, M., Dargusch, R., Roberts, A., Riek, R., Eichmann, C., Chiruta, C., Akaishi, T., Abe, K., Maher, P., Schubert, D. A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease PLoS One 2011 6:e27865 DOI:10.1371/journal.pone.0027865 PMID:22194796 PMCID:PMC3237323
- Trujillo, J. L., Do, D. T., Grahame, N. J., Roberts, A. J., Gorman, M. R. Ethanol consumption in mice: Relationships with circadian period and entrainment Alcohol 2011 45:147-159 DOI:10.1016/j.alcohol.2010.08.016 PMID:20880659 PMCID:PMC4878854
- Treweek, J. B., Roberts, A. J., Janda, K. D. Immunopharmacotherapeutic manifolds and modulation of cocaine overdose Pharmacology, Biochemistry and Behavior 2011 98:474-484 DOI:10.1016/j.pbb.2011.02.020 PMID:21356233 PMCID:PMC3069656
- Amador-Arjona, A., Elliott, J., Miller, A., Ginbey, A., Pazour, G. J., Enikolopov, G., Roberts, A. J., Terskikh, A. V. Primary cilia regulate proliferation of amplifying progenitors in adult hippocampus: Implications for learning and memory Journal of Neuroscience 2011 31:9933-9944 DOI:10.1523/jneurosci.1062-11.2011 PMID:21734285
- Repunte-Canonigo, V., Berton, F., Cottone, P., Reifel-Miller, A., Roberts, A. J., Morales, M., Francesconi, W., Sanna, P. P. A potential role for adiponectin receptor 2 (AdipoR2) in the regulation of alcohol intake Brain Research 2010 1339:11-17 DOI:10.1016/j.brainres.2010.03.060 PMID:20380822 PMCID:PMC2906226
- Roberts, A. J., Maung, R., Sejbuk, N. E., Ake, C., Kaul, M. Alteration of methamphetamine-induced stereotypic behaviour in transgenic mice expressing hiv-1 envelope protein gp120 Journal of Neuroscience Methods 2010 186:222-225 DOI:10.1016/j.jneumeth.2009.11.007 PMID:19917310 PMCID:PMC3432271
- Repunte-Canonigo, V., van der Stap, L. D., Chen, J. H., Sabino, V., Wagner, U., Zorrilla, E. P., Schumann, G., Roberts, A. J., Sanna, P. P. Genome-wide gene expression analysis identifies K-ras as a regulator of alcohol intake Brain Research 2010 1339:1-10 DOI:10.1016/j.brainres.2010.03.063 PMID:20388501 PMCID:PMC2925131
- Zhou, X., Nie, Z., Roberts, A., Zhang, D., Sebat, J., Malhotra, D., Kelsoe, J. R., Geyer, M. A. Reduced NMDAR1 expression in the Sp4 hypomorphic mouse may contribute to endophenotypes of human psychiatric disorders Human Molecular Genetics 2010 19:3797-3805 DOI:10.1093/hmg/ddq298 PMID:20634195 PMCID:PMC2935857
- Treweek, J. B., Roberts, A. J., Janda, K. D. Superadditive effects of ethanol and flunitrazepam: Implications of using immunopharmacotherapy as a therapeutic Molecular Pharmaceutics 2010 7:2056-2068 DOI:10.1021/mp900293a PMID:20849117 PMCID:PMC2997924
- Sarkisyan, G., Roberts, A. J., Hedlund, P. B. The 5-HT(7) receptor as a mediator and modulator of antidepressant-like behavior Behavioural Brain Research 2010 209:99-108 DOI:10.1016/j.bbr.2010.01.022 PMID:20097233 PMCID:PMC2832919
- Yang, G., Badeanlou, L., Bielawski, J., Roberts, A. J., Hannun, Y. A., Samad, F. Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome American Journal of Physiology-Endocrinology and Metabolism 2009 297:E211-E224 DOI:10.1152/ajpendo.91014.2008 PMID:19435851 PMCID:PMC2711669
- Trujillo, J. L., Roberts, A. J., Gorman, M. R. Circadian timing of ethanol exposure exerts enduring effects on subsequent ad libitum consumption in c57 mice Alcoholism-Clinical and Experimental Research 2009 33:1286-1293 DOI:10.1111/j.1530-0277.2009.00954.x PMID:19389184 PMCID:PMC3073399
- Wang, J. P., Dunn, A. J., Roberts, A. J., Zhang, H. Decreased immobility in swimming test by homologous interferon-alpha in mice accompanied with increased cerebral tryptophan level and serotonin turnover Neuroscience Letters 2009 452:96-100 DOI:10.1016/j.neulet.2009.01.050 PMID:19383422 PMCID:PMC2680382
- Carmona, M. A., Murai, K. K., Wang, L., Roberts, A. J., Pasquale, E. B. Glial ephrin-a3 regulates hippocampal dendritic spine morphology and glutamate transport Proceedings of the National Academy of Sciences of the United States of America 2009 106:12524-12529 DOI:10.1073/pnas.0903328106 PMID:19592509 PMCID:PMC2718351
- Dugan, L. L., Ali, S. S., Shekhtman, G., Roberts, A. J., Lucero, J., Quick, K. L., Behrens, M. M. IL-6 mediated degeneration of forebrain GABAergic interneurons and cognitive impairment in aged mice through activation of neuronal NADPH oxidase PLoS One 2009 4:e5518 DOI:10.1371/journal.pone.0005518 PMID:19436757 PMCID:PMC2678193
- Barros, C. S., Calabrese, B., Chamero, P., Roberts, A. J., Korzus, E., Lloyd, K., Stowers, L., Mayford, M., Halpain, S., Muller, U. Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system Proceedings of the National Academy of Sciences of the United States of America 2009 106:4507-4512 DOI:10.1073/pnas.0900355106 PMID:19240213 PMCID:PMC2657442
- Kang-Park, M. H., Kieffer, B. L., Roberts, A. J., Roberto, M., Madamba, S. G., Siggins, G. R., Moore, S. D. Mu-opioid receptors selectively regulate basal inhibitory transmission in the central amygdala: Lack of ethanol interactions Journal of Pharmacology and Experimental Therapeutics 2009 328:284-293 DOI:10.1124/jpet.108.140749 PMID:18854491 PMCID:PMC2685907
- Paneda, C., Huitron-Resendiz, S., Frago, L. M., Chowen, J. A., Picetti, R., de Lecea, L., Roberts, A. J. Neuropeptide s reinstates cocaine-seeking behavior and increases locomotor activity through corticotropin-releasing factor receptor 1 in mice Journal of Neuroscience 2009 29:4155-4161 DOI:10.1523/jneurosci.5256-08.2009 PMID:19339610 PMCID:PMC3437665
- Du, X., Schwander, M., Moresco, E. M. Y., Viviani, P., Haller, C., Hildebrand, M. S., Pak, K., Tarantino, L., Roberts, A., Richardson, H., Koob, G., Najmabadi, H., et al. A catechol-O-methyltransferase that is essential for auditory function in mice and humans Proceedings of the National Academy of Sciences of the United States of America 2008 105:14609-14614 DOI:10.1073/pnas.0807219105 PMID:18794526 PMCID:PMC2567147
- Papaleo, F., Ghozland, S., Ingallinesi, M., Roberts, A. J., Koob, G. F., Contarino, A. Disruption of the CRF(2) receptor pathway decreases the somatic expression of opiate withdrawal Neuropsychopharmacology 2008 33:2878-2887 DOI:10.1038/npp.2008.8 PMID:18288089 PMCID:PMC2760329
- Li, Z., McKercher, S. R., Cui, J., Nie, Z. G., Soussou, W., Roberts, A. J., Sallmen, T., Lipton, J. H., Talantova, M., Okamoto, S. I., Lipton, S. A. Myocyte enhancer factor 2C as a neurogenic and antiapoptotic transcription factor in murine embryonic stem cells Journal of Neuroscience 2008 28:6557-6568 DOI:10.1523/jneurosci.0134-08.2008 PMID:18579729 PMCID:PMC2679693
- Treweek, J. B., Sun, C., Mayorov, A. V., Qi, L., Levy, C. L., Roberts, A. J., Dickerson, T. J., Janda, K. D. Prevention of drug-induced memory impairment by immunopharmacotherapy Journal of Medicinal Chemistry 2008 51:6866-6875 DOI:10.1021/jm800506v PMID:18921991 PMCID:PMC2661766
- Li, H., Radford, J. C., Ragusa, M. J., Shea, K. L., McKercher, S. R., Zaremba, J. D., Soussou, W., Nie, Z., Nakanishi, N., Okamoto, S. I., Roberts, A. J., Schwarz, J. J. Transcription factor mef2c influences neural stem/progenitor cell differentiation and maturation in vivo Proceedings of the National Academy of Sciences of the United States of America 2008 105:9397-9402 DOI:10.1073/pnas.0802876105 PMID:18599437 PMCID:PMC2453715
- Buxbaum, J. N., Ye, Z., Reixach, N., Friske, L., Levy, C., Das, P., Golde, T., Masliah, E., Roberts, A. R., Bartfai, T. Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of a beta toxicity Proceedings of the National Academy of Sciences of the United States of America 2008 105:2681-2686 DOI:10.1073/pnas.0712197105 PMID:18272491 PMCID:PMC2268196
- Prut, L., Abramowski, D., Krucker, T., Levy, C. L., Roberts, A. J., Staufenbiel, M., Wiessner, C. Aged app23 mice show a delay in switching to the use of a strategy in the barnes maze Behavioural Brain Research 2007 179:107-110 DOI:10.1016/j.bbr.2007.01.017 PMID:17324476
- Chu, K., Koob, G. F., Cole, M., Zorrilla, E. P., Roberts, A. J. Dependence-induced increases in ethanol self-administration in mice are blocked by the crf, receptor antagonist antalarmin and by crf, receptor knockout Pharmacology, Biochemistry and Behavior 2007 86:813-821 DOI:10.1016/j.pbb.2007.03.009 PMID:17482248 PMCID:PMC2170886
- Finn, D. A., Snelling, C., Fretwell, A. M., Tanchuck, M. A., Underwood, L., Cole, M., Crabbe, J. C., Roberts, A. J. Increased drinking during withdrawal from intermittent ethanol exposure is blocked by the CRF receptor antagonist D-Phe-CRF(12-41) Alcoholism-Clinical and Experimental Research 2007 31:939-949 DOI:10.1111/j.1530-0277.2007.00379.x PMID:17403068
- Newton, P. M., Kim, J. A., McGeehan, A. J., Paredes, J. P., Chu, K., Wallace, M. J., Roberts, A. J., Hodge, C. W., Messing, R. O. Increased response to morphine in mice lacking protein kinase c epsilon Genes Brain and Behavior 2007 6:329-338 DOI:10.1111/j.1601-183X.2006.00261.x PMID:16899053 PMCID:PMC4264050
- Kang-Park, M. H., Kieffer, B. L., Roberts, A. J., Siggins, G. R., Moore, S. D. Presynaptic delta opioid receptors regulate ethanol actions in central amygdala Journal of Pharmacology and Experimental Therapeutics 2007 320:917-925 DOI:10.1124/jpet.106.112722 PMID:17114568
- Katner, S. N., Von Huben, S. N., Davis, S. A., Lay, C. C., Crean, R. D., Roberts, A. J., Fox, H. S., Taffe, M. A. Robust and stable drinking behavior following long-term oral alcohol intake in rhesus macaques Drug and Alcohol Dependence 2007 91:236-243 DOI:10.1016/j.drugalcdep.2007.06.002 PMID:17628350 PMCID:PMC2231844
- Metten, P., Buck, K. J., Merrill, C. M., Roberts, A. J., Yu, C. H., Crabbe, J. C. Use of a novel mouse genotype to model acute benzodiazepine withdrawal Behavior Genetics 2007 37:160-170 DOI:10.1007/s10519-006-9094-3 PMID:17226103
- Kunz, S., Rojek, J. M., Roberts, A. J., McGavern, D. B., Oldstone, M. B. A., de la Torre, J. C. Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus Journal of Virology 2006 80:9082-9092 DOI:10.1128/jvi.00795-06 PMID:16940520
- Chen, A., Zorrilla, E., Smith, S., Rousso, D., Levy, C., Vaughan, J., Donaldson, C., Roberts, A., Lee, K. F., Vale, W. Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior Journal of Neuroscience 2006 26:5500-5510 DOI:10.1523/jneurosci.3955-05.2006 PMID:16707802
- Tallent, M. K., Veronique, F., Qiu, C., Calbet, M., Lamp, T., Baratta, M. V., Suzuki, C., Levy, C. L., Siggins, G. R., Henriksen, S. J., Criado, J. R., Roberts, A., et al. Cortistatin overexpression in transgenic mice produces deficits in synaptic plasticity and learning Molecular and Cellular Neuroscience 2005 30:465-475 DOI:10.1016/j.mcn.2005.08.010 PMID:16182561
- Carrera, M. R. A., Trigo, J. M., Wirsching, P., Roberts, A. J., Janda, K. D. Evaluation of the anticocaine monoclonal antibody GNC92H2 as an immunotherapy for cocaine overdose Pharmacology, Biochemistry and Behavior 2005 81:709-714 DOI:10.1016/j.pbb.2005.04.018 PMID:16005948
- Ghozland, S., Chu, K., Kieffer, B. L., Roberts, A. J. Lack of stimulant and anxiolytic-like effects of ethanol and accelerated development of ethanol dependence in mu-opioid receptor knockout mice Neuropharmacology 2005 49:493-501 DOI:10.1016/j.neuropharm.2005.04.006 PMID:15961126
- Tabarin, A., Chaves, Y. D., Carmona, M. D., Catargi, B., Zorrilla, E. P., Roberts, A. J., Coscina, D. V., Rousset, S., Redonnet, A., Parker, G. C., Inoue, K., Ricquier, D., et al. Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: Evidence for a "thrifty gene" Diabetes 2005 54:3510-3516 DOI:10.2337/diabetes.54.12.3510 PMID:16306369
- Sanchis-Segura, C., Grisel, J. E., Olive, M. F., Ghozland, S., Koob, G. F., Roberts, A. J., Cowen, M. S. Role of the endogenous opioid system on the neuropsychopharmacological effects of ethanol: New insights about an old question Alcoholism-Clinical and Experimental Research 2005 29:1522-1527 DOI:10.1097/01.alc.0000174913.60384.e8 PMID:16156049
- Breese, G. R., Chu, K., Dayas, C. V., Funk, D., Knapp, D. J., Koob, G. F., Le, D. A., O'Dell, L. E., Overstreet, D. H., Roberts, A. J., Sinha, R., Valdez, G. R., et al. Stress enhancement of craving during sobriety: A risk for relapse Alcoholism-Clinical and Experimental Research 2005 29:185-195 DOI:10.1097/01.alc.0000153544.83656.3c PMID:15714042
- Katner, S. N., Flynn, C. T., Von Huben, S. N., Kirsten, A. J., Davis, S. A., Lay, C. C., Cole, M., Roberts, A. J., Fox, H. S., Taffe, M. A. Controlled and behaviorally relevant levels of oral ethanol intake in rhesus macaques using a flavorant-fade procedure Alcoholism-Clinical and Experimental Research 2004 28:873-883 DOI:10.1097/01.alc.0000128895.99379.8c PMID:15201630
- Risbrough, V. B., Hauger, R. L., Roberts, A. L., Vale, W. W., Geyer, M. A. Corticotropin-releasing factor receptors CRF1 and CRF2 exert both additive and opposing influences on defensive startle behavior Journal of Neuroscience 2004 24:6545-6552 DOI:10.1523/jneurosci.5760-03.2004 PMID:15269266
- O'Dell, L. E., Roberts, A. J., Smith, R. T., Koob, G. F. Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure Alcoholism-Clinical and Experimental Research 2004 28:1676-1682 DOI:10.1097/01.alc.0000145781.11923.4e PMID:15547454
- Nie, Z. G., Schweitzer, P., Roberts, A. J., Madamba, S. G., Moore, S. D., Siggins, G. R. Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors Science 2004 303:1512-1514 DOI:10.1126/science.1092550 PMID:15001778
- Winsky-Sommerer, R., Yamanaka, A., Diano, S., Borok, E., Roberts, A. J., Sakurai, T., Kilduff, T. S., Horvath, T. L., de Lecea, L. Interaction between the corticotropin-releasing factor system and hypocretins (orexins): A novel circuit mediating stress response Journal of Neuroscience 2004 24:11439-11448 DOI:10.1523/jneurosci.3459-04.2004 PMID:15601950
- Roberts, A. J., Krucker, T., Levy, C. L., Slanina, K. A., Sutcliffe, J. G., Hedlund, P. B. Mice lacking 5-ht7 receptors show specific impairments in contextual learning European Journal of Neuroscience 2004 19:1913-1922 DOI:10.1111/j.1460.9568.2004.03288.x PMID:15078565
- Koob, G. F., Roberts, A. J., Kieffer, B. L., Heyser, C. J., Katner, S. N., Ciccocioppo, R., Weiss, F. Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology Recent Developments in Alcoholism 2003 16:263-281 DOI:10.1007/0-306-47939-7_19 PMID:12638642
- Valdez, G. R., Zorrilla, E. P., Roberts, A. J., Koob, G. F. Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence Alcohol 2003 29:55-60 DOI:10.1016/s0741-8329(03)00020-x PMID:12782246
- Bale, T. L., Anderson, K. R., Roberts, A. J., Lee, K. F., Nagy, T. R., Vale, W. W. Corticotropin-releasing factor receptor-2-deficient mice display abnormal homeostatic responses to challenges of increased dietary fat and cold Endocrinology 2003 144:2580-2587 DOI:10.1210/en.2002-0091 PMID:12746321
- Finn, D. A., Roberts, A. J., Long, S., Tanchuck, M., Phillips, T. J. Neurosteroid consumption has anxiolytic effects in mice Pharmacology, Biochemistry and Behavior 2003 76:451-462 DOI:10.1016/j.pbb.2003.09.004 PMID:14643844
- Valdez, G. R., Roberts, A. J., Chan, K., Davis, H., Brennan, M., Zorrilla, E. P., Koob, G. F. Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: Regulation by corticotropin-releasing factor Alcoholism-Clinical and Experimental Research 2002 26:1494-1501 DOI:10.1097/01.alc.0000033120.51856.f0 PMID:12394282
- Ryabinin, A. E., Bachtell, R. K., Heinrichs, S. C., Lee, S., Rivier, C., Olive, M. F., Mehmert, K. K., Camarini, R., Kim, J. A., Koenig, H. N., Nannini, M. A., Hodge, C. W., et al. The corticotropin-releasing factor/urocortin system and alcohol Alcoholism-Clinical and Experimental Research 2002 26:714-722 DOI:10.1111/j.1530-0277.2002.tb02596.x PMID:12045481
- Roberts, A. J., Gold, L. H., Polis, L., McDonald, J. S., Filliol, D., Kieffer, B. L., Koob, G. F. Increased ethanol self-administration in delta-opioid receptor knockout mice Alcoholism-Clinical and Experimental Research 2001 25:1249-1256 DOI:10.1111/j.1530-0277.2001.tb02344.x PMID:11584142
- Koob, G., Bartfai, T., Roberts, A. J. Molecular genetic approaches to the neuropharmacology of corticotropin releasing factor International Journal of Comparative Psychology 2001 14:90-110
- Le, A. D., Kiianmaa, K., Cunningham, C. L., Engel, J. A., Ericson, M., Soderpalm, B., Koob, G. F., Roberts, A. J., Weiss, F., Hyytia, P., Janhunen, S., Mikkola, J., et al. Neurobiological processes in alcohol addiction Alcoholism-Clinical and Experimental Research 2001 25:144S-151S DOI:10.1111/j.1530-0277.2001.tb02389.x PMID:11391064
- Flannery, B. A., Roberts, A. J., Cooney, N., Swift, R. M., Anton, R. F., Rohsenow, D. J. The role of craving in alcohol use, dependence, and treatment Alcoholism-Clinical and Experimental Research 2001 25:299-308 DOI:10.1111/j.1530-0277.2001.tb02213.x PMID:11236847
- Roberts, A. J., Heyser, C. J., Cole, M., Griffin, P., Koob, G. F. Excessive ethanol drinking following a history of dependence: Animal model of allostasis Neuropsychopharmacology 2000 22:581-594 DOI:10.1016/s0893-133x(99)00167-0 PMID:10788
- Roberts, A. J., McDonald, J. S., Heyser, C. J., Kieffer, B. L., Matthes, H. W. D., Koob, G. F., Gold, L. H. Mu-opioid receptor knockout mice do not self-administer alcohol Journal of Pharmacology and Experimental Therapeutics 2000 293:1002-1008 PMID:10869404
- Roberts, A., Heyser, C., Koob, G. Blood alcohol concentrations in rats drinking or intubated with ethanol. Response Alcoholism-Clinical and Experimental Research 1999 23:1946-1947 DOI:10.1111/j.1530-0277.1999.tb04098.x PMID:10630615
- Koob, G. F., Roberts, A. J. Brain reward circuits in alcoholism CNS Spectrums 1999 4:23-37
- Rodrigquez De Fonseca, F., Roberts, A. J., Bilbao, A., Koob, G. F., Navarro, M. Cannabinoid receptor antagonist SR141716a decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers Acta Pharmacologica Sinica 1999 20:1109-1114 PMID:11189201
- Heyser, C. J., Roberts, A. J., Schulteis, G., Koob, G. F. Central administration of an opiate antagonist decreases oral ethanol self-administration in rats Alcoholism-Clinical and Experimental Research 1999 23:1468-1476 DOI:10.1097/00000374-199909000-00008 PMID:10512312
- Roberts, A. J., Heyser, C. J., Koob, G. F. Operant self-administration of sweetened versus unsweetened ethanol: effects on blood alcohol levels Alcoholism-Clinical and Experimental Research 1999 23:1151-1157 DOI:10.1097/00000374-199907000-00003 PMID:10443980
- Navarro, M., Chowen, J., Carrera, M. R. A., del Arco, I., Villanua, M. A., Martin, Y., Roberts, A. J., Koob, G. F., de Fonseca, F. R. Cb1 cannabinoid receptor antagonist-induced opiate withdrawal in morphine-dependent rats Neuroreport 1998 9:3397-3402 DOI:10.1097/00001756-199810260-00012 PMID:9855288
- Roberts, A. J., McArthur, R. A., Hull, E. E., Post, C., Koob, G. F. Effects of amperozide, 8-OH-DPAT, and FG 5974 on operant responding for ethanol Psychopharmacology 1998 137:25-32 DOI:10.1007/s002130050589 PMID:9631953
- Roberts, A. J., Smith, A. D., Weiss, F., Rivier, C., Koob, G. F. Estrous cycle effects on operant responding for ethanol in female rats Alcoholism-Clinical and Experimental Research 1998 22:1564-1569 DOI:10.1097/00000374-199810000-00028 PMID:9802543
- Koob, G. F., Roberts, A. J., Schulteis, G., Parsons, L. H., Heyser, C. J., Hyytia, P., Merlo-Pich, E., Weiss, F. Neurocircuitry targets in ethanol reward and dependence Alcoholism-Clinical and Experimental Research 1998 22:3-9 DOI:10.1097/00000374-199802000-00001 PMID:9514280
- Koob, G. F., Rocio, M., Carrera, A., Gold, L. H., Heyser, C. J., Maldonado-Irizarry, C., Markou, A., Parsons, L. H., Roberts, A. J., Schulteis, G., Stinus, L., Walker, J. R., et al. Substance dependence as a compulsive behavior Journal of Psychopharmacology 1998 12:39-48 DOI:10.1177/026988119801200106 PMID:9584967
- Phillips, T. J., Roberts, A. J., Lessov, C. N. Behavioral sensitization to ethanol: Genetics and the effects of stress Pharmacology, Biochemistry and Behavior 1997 57:487-493 DOI:10.1016/s0091-3057(96)00448-0 PMID:9218273
- Finn, D. A., Roberts, A. J., Lotrich, F., Gallaher, E. J. Genetic differences in behavioral sensitivity to a neuroactive steroid Journal of Pharmacology and Experimental Therapeutics 1997 280:820-828 PMID:9023296
- Roberts, A. J., Polis, I. Y., Gold, L. H. Intravenous self-administration of heroin, cocaine, and the combination in balb/c mice European Journal of Pharmacology 1997 326:119-125 DOI:10.1016/s0014-2999(97)85405-2 PMID:9196263
- Roberts, A. J., Koob, G. F. The neurobiology of addiction: an overview Alcohol Health and Research World 1997 21:101-106 PMID:15704343
- Gold, L. H., Heyser, C. J., Roberts, A. J., Henriksen, S. J., Steffensen, S. C., Siggins, G. R., Bellinger, F. P., Chiang, C. S., Powell, H. C., Masliah, E., Campbell, I. L. Behavioral and neurophysiological effects of CNS expression of cytokines in transgenic mice Advances in Experimental Medicine and Biology 1996 402:199-205 DOI:10.1007/978-1-4613-0407-4_26 PMID:8787661
- Roberts, A. J., Cole, M., Koob, G. F. Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats Alcoholism-Clinical and Experimental Research 1996 20:1289-1298 DOI:10.1111/j.1530-0277.1996.tb01125.x PMID:8904984
- Roberts, A. J., Keith, L. D. Corticosteroids enhance convulsion susceptibility via central mineralocorticoid receptors Psychoneuroendocrinology 1995 20:891-902 DOI:10.1016/0306-4530(95)00016-x PMID:88340
- Roberts, A. J., Lessov, C. N., Phillips, T. J. Critical role for glucocorticoid receptors in stress-induced and ethanol-induced locomotor sensitization Journal of Pharmacology and Experimental Therapeutics 1995 275:790-797 PMID:7473168
- Roberts, A. J., Phillips, T. J., Belknap, J. K., Finn, D. A., Keith, L. D. Genetic analysis of the corticosterone response to ethanol in bxd recombinant inbred mice Behavioral Neuroscience 1995 109:1199-1208 DOI:10.1037//0735-7044.109.6.1199 PMID:8748968
- Finn, D. A., Roberts, A. J., Crabbe, J. C. Neuroactive steroid sensitivity in withdrawal seizure-prone and -resistant mice Alcoholism-Clinical and Experimental Research 1995 19:410-415 DOI:10.1111/j.1530-0277.1995.tb01523.x PMID:7625575
- Roberts, A. J., Crabbe, J. C., Keith, L. D. Corticosterone increases severity of acute withdrawal from ethanol, pentobarbital, and diazepam in mice Psychopharmacology 1994 115:278-284 DOI:10.1007/bf02244784 PMID:7862907
- Roberts, A. J., Keith, L. D. Mineralocorticoid receptors mediate the enhancing effects of corticosterone on convulsion susceptibility in mice Journal of Pharmacology and Experimental Therapeutics 1994 270:505-511 PMID:8071844
- Roberts, A. J., Keith, L. D. Sensitivity of the circadian-rhythm of kainic acid-induced convulsion susceptibility to manipulations of corticosterone levels and mineralocorticoid receptor-binding Neuropharmacology 1994 33:1087-1093 DOI:10.1016/0028-3908(94)90147-3 PMID:7838321
- Roberts, A. J., Gallaher, E. J., Keith, L. D. Dissociation of the effect of aminoglutethimide on corticosterone biosynthesis from ataxic and hypothermic effects in DBA and C57 mice Neuroendocrinology 1993 58:303-309 DOI:10.1159/000126554 PMID:8255391
- Roberts, A. J., Crabbe, J. C., Keith, L. D. Type I corticosteroid receptors modulate PTZ-induced convulsions of withdrawal seizure prone mice Brain Research 1993 626:143-148 DOI:10.1016/0006-8993(93)90573-6 PMID:8281425
- Roberts, A. J., Crabbe, J. C., Keith, L. D. Genetic differences in hypothalamic-pituitary-adrenal axis responsiveness to acute ethanol and acute ethanol withdrawal Brain Research 1992 579:296-302 DOI:10.1016/0006-8993(92)90064-g PMID:1320985
- Roberts, A. J., Chu, H. P., Crabbe, J. C., Keith, L. D. Differential modulation by the stress axis of ethanol withdrawal seizure expression in WSP and WSR mice Alcoholism-Clinical and Experimental Research 1991 15:412-417 DOI:10.1111/j.1530-0277.1991.tb00539.x PMID:1652218
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thesis