recent publications
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academic article
- Hu, Juan, Cochrane, Wesley G., Jones, Alexander X., Blackmond, D. G., Paegel, B. M. Chiral lipid bilayers are enantioselectively permeable Nature Chemistry 2021 13:786-791 DOI:10.1038/s41557-021-00708-z PMID:34112989 PMCID:PMC8325640
- Cochrane, W. G., Fitzgerald, P. R., Paegel, B. M. Antibacterial Discovery via Phenotypic DNA-Encoded Library Screening ACS Chemical Biology 2021 16:2752-2756 DOI:10.1021/acschembio.1c00714 PMID:34806373 PMCID:PMC8688339
- Price, A. K., Paegel, B. M. Considerations for Achieving Maximized DNA Recovery in Solid-Phase DNA-Encoded Library Synthesis ACS Combinatorial Science 2020 22:649-655 DOI:10.1021/acscombsci.0c00101 PMID:32786319 PMCID:PMC7655546
- Matos, J. L. M., Green, S. A., Chun, Y. G., Dang, V. Q., Dushin, R. G., Richardson, P., Chen, J. S., Piotrowski, D. W., Paegel, B. M., Shenvi, R. A. Cycloisomerization of Olefins in Water Angewandte Chemie-International Edition 2020 DOI:10.1002/anie.202003948 PMID:32285542
- Hackler, A. L., FitzGerald, F. G., Dang, V. Q., Satz, A. L., Paegel, B. M. Off-DNA DNA-encoded library affinity screening ACS Combinatorial Science 2020 22:25-34 DOI:10.1021/acscombsci.9b00153 PMID:31829554 PMCID:PMC6957756
- Ratnayake, A. S., Flanagan, M. E., Foley, T. L., Smith, J. D., Johnson, J. G., Bellenger, J., Montgomery, J. I., Paegel, B. M. A solution phase platform to characterize chemical reaction compatibility with DNA-encoded chemical library synthesis ACS Combinatorial Science 2019 21:650-655 DOI:10.1021/acscombsci.9b00113 PMID:31425646
- Vallejo, D., Nikoomanzar, A., Paegel, B. M., Chaput, J. C. Fluorescence-activated droplet sorting for single-cell directed evolution ACS Synthetic Biology 2019 8:1430-1440 DOI:10.1021/acssynbio.9b00103 PMID:31120731
- Cochrane, W. G., Malone, M. L., Dane, V. Q., Cavett, V., Satz, A. L., Paegel, B. M. Activity-Based DNA-Encoded Library Screening ACS Combinatorial Science 2019 21:425-435 DOI:10.1021/acscombsci.9b00037 PMID:30884226
- Cochrane, W. G., Hackler, A. L., Cavett, V. J., Price, A. K., Paegel, B. M. Integrated, continuous emulsion creamer Analytical Chemistry 2017 89:13227-13234 DOI:10.1021/acs.analchem.7b03070 PMID:29124927
- MacConnell, A. B., Paegel, B. M. Poisson statistics of combinatorial library sampling predict false discovery rates of screening ACS Combinatorial Science 2017 19:524-532 DOI:10.1021/acscombsci.7b00061 PMID:28682059 PMCID:PMC5558193
- MacConnell, A. B., Price, A. K., Paegel, B. M. An integrated microfluidic processor for DNA-encoded combinatorial library functional screening ACS Combinatorial Science 2017 19:181-192 DOI:10.1021/acscombsci.6b00192 PMID:28199790 PMCID:PMC5350604
- Malone, M. L., Cavett, V. J., Paegel, B. M. Chemoselective coupling preserves the substrate integrity of surface-immobilized oligonucleotides for emulsion PCR-based gene library construction ACS Combinatorial Science 2017 19:9-14 DOI:10.1021/acscombsci.6b00146 PMID:28064476 PMCID:PMC5243130
- Mendes, K. R., Malone, M. L., Ndungu, J. M., Suponitsky-Kroyter, I., Cavett, V. J., McEnaney, P. J., MacConnell, A. B., Doran, T. M., Ronacher, K., Stanley, K., Utset, O., Walzl, G., et al. High-throughput identification of DNA-encoded IgG ligands that distinguish active and latent Mycobacterium tuberculosis infections ACS Chemical Biology 2017 12:234-243 DOI:10.1021/acschembio.6b00855 PMID:27957856 PMCID:PMC5250564
- Tran, D. T., Cavett, V. J., Dang, V. Q., Torres, H. L., Paegel, B. M. Evolution of a mass spectrometry-grade protease with PTM-directed specificity Proceedings of the National Academy of Sciences of the United States of America 2016 113:14686-14691 DOI:10.1073/pnas.1609925113 PMID:27940920 PMCID:PMC5187733
- Malone, M. L., Paegel, B. M. What is a "DNA-compatible" reaction? ACS Combinatorial Science 2016 18:182-187 DOI:10.1021/acscombsci.5b00198 PMID:26971959 PMCID:PMC4946796
- Price, A. K., MacConnell, A. B., Paegel, B. M. hvSABR: photochemical dose-response bead screening in droplets Analytical Chemistry 2016 88:2904-2911 DOI:10.1021/acs.analchem.5b04811 PMID:26815064 PMCID:PMC4776284
- Price, A. K., Paegel, B. M. Discovery in droplets Analytical Chemistry 2016 88:339 DOI:10.1021/acs.analchem.5b04139 PMID:26558892 PMCID:PMC4865373
- MacConnell, A. B., McEnaney, P. J., Cavett, V. J., Paegel, B. M. DNA-encoded solid-phase synthesis: encoding language design and complex oligomer library synthesis ACS Combinatorial Science 2015 17:518-534 DOI:10.1021/acscombsci.5b00106 PMID:26290177 PMCID:PMC4571006
- Price, A. K., MacConnell, A. B., Paegel, B. M. Microfluidic bead suspension hopper Analytical Chemistry 2014 86:5039-5044 DOI:10.1021/ac500693r PMID:24761972 PMCID:PMC4029372
- Matosevic, S., Paegel, B. M. Layer-by-layer cell membrane assembly Nature Chemistry 2013 5:958-963 DOI:10.1038/nchem.1765 PMID:24153375 PMCID:PMC4003896
- Matosevic, S., Paegel, B. M. Stepwise synthesis of giant unilamellar vesicles on a microfluidic assembly line Journal of the American Chemical Society 2011 133:2798-2800 DOI:10.1021/ja109137s PMID:21309555 PMCID:PMC3048828
- Paegel, B. M. Microfluidic landscapes for evolution Current Opinion in Chemical Biology 2010 14:568-573 DOI:10.1016/j.cbpa.2010.07.023 PMID:20800535 PMCID:PMC2953605
- Paegel, B. M., Joyce, G. F. Microfluidic compartmentalized directed evolution Chemistry & Biology 2010 17:717-724 DOI:10.1016/j.chembiol.2010.05.021 PMID:20659684 PMCID:PMC2912841
- Paegel, B. M., Joyce, G. F. Darwinian evolution on a chip PLoS Biology 2008 6:e85 DOI:10.1371/journal.pbio.0060085 PMID:18399721 PMCID:PMC2288630
- Paegel, B. M., Grover, W. H., Skelley, A. M., Mathies, R. A., Joyce, G. F. Microfluidic serial dilution circuit Analytical Chemistry 2006 78:7522-7527 DOI:10.1021/ac0608265 PMID:17073422 PMCID:PMC2566538
- Doherty, E. A. S., Kan, C. W., Paegel, B. M., Yeung, S. H. I., Cao, S., Mathies, R. A., Barron, A. E. Sparsely cross-linked "nanogel" matrixes as fluid, mechanically stabilized polymer networks for high-throughput microchannel DNA sequencing Analytical Chemistry 2004 76:5249-5256 DOI:10.1021/ac049721x PMID:15362880
- Kamei, T., Paegel, B. M., Scherer, J. R., Skelley, A. M., Street, R. A., Mathies, R. A. Fusion of a-Si:H sensor technology with microfluidic bioanalytical devices Journal of Non-Crystalline Solids 2004 338:715-719 DOI:10.1016/j.jnoncrysol.2004.03.117
- Kamei, T., Paegel, B. M., Scherer, J. R., Skelley, A. M., Street, R. A., Mathies, R. A. Integrated hydrogenated amorphous Si photodiode detector for microfluidic bioanalytical devices Analytical Chemistry 2003 75:5300-5305 DOI:10.1021/ac0301550 PMID:14710806
- Paegel, B. M., Blazej, R. G., Mathies, R. A. Microfluidic devices for DNA sequencing: sample preparation and electrophoretic analysis Current Opinion in Biotechnology 2003 14:42-50 DOI:10.1016/s0958-1669(02)00004-6 PMID:12566001
- Blazej, R. G., Paegel, B. M., Mathies, R. A. Polymorphism ratio sequencing: a new approach for single nucleotide polymorphism discovery and genotyping Genome Research 2003 13:287-293 DOI:10.1101/gr.396203 PMID:12566407 PMCID:PMC420372
- Paegel, B. M., Yeung, S. H. I., Mathies, R. A. Microchip bioprocessor for integrated nanovolume sample purification and DNA sequencing Analytical Chemistry 2002 74:5092-5098 DOI:10.1021/ac0203645 PMID:12380835
- Paegel, B. M., Emrich, C. A., Weyemayer, G. J., Scherer, J. R., Mathies, R. A. High throughput DNA sequencing with a microfabricated 96-lane capillary array electrophoresis bioprocessor Proceedings of the National Academy of Sciences of the United States of America 2002 99:574-579 DOI:10.1073/pnas.012608699 PMID:11792836 PMCID:PMC117347
- Scherer, J. R., Paegel, B. M., Wedemayer, G. J., Emrich, C. A., Lo, J., Medintz, I. L., Mathies, R. A. High-pressure gel loader for capillary array electrophoresis microchannel plates Biotechniques 2001 31:1150-1154 PMID:11730021
- Medintz, I. L., Paegel, B. M., Blazej, R. G., Emrich, C. A., Berti, L., Scherer, J. R., Mathies, R. A. High-performance genetic analysis using microfabricated capillary array electrophoresis microplates Electrophoresis 2001 22:3845-3856 DOI:10.1002/1522-2683(200110)22:18<3845::aid-elps3845>3.0.co;2-0 PMID:11700713
- Medintz, I. L., Paegel, B. M., Mathies, R. A. Microfabricated capillary array electrophoresis DNA analysis systems Journal of Chromatography A 2001 924:265-270 DOI:10.1016/s0021-9673(01)00852-4 PMID:11521873
- Paegel, B. M., Hutt, L. D., Simpson, P. C., Mathies, R. A. Turn geometry for minimizing band broadening in microfabricated capillary electrophoresis channels Analytical Chemistry 2000 72:3030-3037 DOI:10.1021/ac000054r PMID:10939363
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