recent publications
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academic article
- Otomo, T., Maeda, S. ATG2A transfers lipids between membranes in vitro Autophagy 2019 11:2031-2032 DOI:10.1080/15548627.2019.1659622 PMID:31441376
- Maeda, S., Otomo, C., Otomo, T. The autophagic membrane tether ATG2A transfers lipids between membranes Elife 2019 8 DOI:10.7554/eLife.45777 PMID:31271352 PMCID:PMC6625793
- Chowdhury, S., Otomo, C., Leitner, A., Ohashi, K., Aebersold, R., Lander, G. C., Otomo, T. Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex Proceedings of the National Academy of Sciences of the United States of America 2018 115:E9792-E9801 DOI:10.1073/pnas.1811874115 PMID:30185561 PMCID:PMC6196511
- Ohashi, K., Otomo, T. Identification and characterization of the linear region of ATG3 that interacts with ATG7 in higher eukaryotes Biochemical and Biophysical Research Communications 2015 463:447-452 DOI:10.1016/j.bbrc.2015.05.107 PMID:26043688 PMCID:PMC4507496
- Metlagel, Z., Otomo, C., Ohashi, K., Takaesu, G., Otomo, T. Structural insights into E2-E3 interaction for LC3 lipidation Autophagy 2014 10:522-523 DOI:10.4161/auto.27594 PMID:24413923 PMCID:PMC4077891
- Metlagel, Z., Otomo, C., Takaesu, G., Otomo, T. Structural basis of ATG3 recognition by the autophagic ubiquitin-like protein ATG12 Proceedings of the National Academy of Sciences of the United States of America 2013 110:18844-18849 DOI:10.1073/pnas.1314755110 PMID:24191030 PMCID:PMC3839761
- Otomo, C., Metlagel, Z., Takaesu, G., Otomo, T. Structure of the human ATG12 similar to ATG5 conjugate required for LC3 lipidation in autophagy Nature Structural & Molecular Biology 2013 20:59-66 DOI:10.1038/nsmb.2431 PMID:23202584 PMCID:PMC3540207
- Otomo, T., Tomchick, D. R., Otomo, C., Machius, M., Rosen, M. K. Crystal structure of the Formin mDia1 in autoinhibited conformation PLoS One 2010 5:e12896 DOI:10.1371/journal.pone.0012896 PMID:20927343 PMCID:PMC2948019
- Shemesh, T., Otomo, T., Rosen, M. K., Bershadsky, A. D., Kozlov, M. M. A novel mechanism of actin filament processive capping by formin: Solution of the rotation paradox Journal of Cell Biology 2005 170:889-893 DOI:10.1083/jcb.200504156 PMID:16157699 PMCID:PMC2171452
- Otomo, T., Otomo, C., Tomchick, D. R., Machius, M., Rosen, M. K. Structural basis of Rho GTPase-mediated activation of the formin rndia1 Molecular Cell 2005 18:273-281 DOI:10.1016/j.molcel.2005.04.002 PMID:15866170
- Otomo, T., Tomchick, D. R., Otomo, C., Panchal, S. C., Machius, M., Rosen, M. K. Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain Nature 2005 433:488-494 DOI:10.1038/nature03251 PMID:15635372
- Seth, A., Otomo, T., Yin, H. L., Rosen, M. K. Rational design of genetically encoded fluorescence resonance energy transfer-based sensors of cellular Cdc42 signaling Biochemistry 2003 42:3997-4008 DOI:10.1021/bi026881z PMID:12680752
- Won, H. S., Yamazaki, T., Lee, T. W., Jee, J. G., Yoon, M. K., Park, S. H., Otomo, T., Aiba, H., Kyogoku, Y., Lee, B. J. Backbone NMR assignments of a high molecular weight protein (47 kDa), cyclic AMP receptor protein (apo-CRP) Journal of Biomolecular NMR 2000 16:79-80 DOI:10.1023/a:1008398103476 PMID:10718614
- Otomo, T., Yamazaki, T., Murakami, K., Ishihama, A., Kyogoku, Y. Structural study of the N-terminal domain of the alpha subunit of escherichia coli RNA polymerase solubilized with non-denaturing detergents Journal of Biochemistry 2000 128:337-344 PMID:10920271
- Uegaki, K., Otomo, T., Sakahira, H., Shimizu, M., Yumoto, N., Kyogoku, Y., Nagata, S., Yamazaki, T. Structure of the CAD domain of caspase-activated DNase and interaction with the CAD domain of its inhibitor Journal of Molecular Biology 2000 297:1121-1128 DOI:10.1006/jmbi.2000.3643 PMID:10764577
- Otomo, T., Sakahira, H., Uegaki, K., Nagata, S., Yamazaki, T. Structure of the heterodimeric complex between CAD domains of CAD and ICAD Nature Structural Biology 2000 7:658-662 DOI:10.1038/77957 PMID:10932250
- Otomo, T., Teruya, K., Uegaki, K., Yamazaki, T., Kyogoku, Y. Improved segmental isotope labeling of proteins and application to a larger protein Journal of Biomolecular NMR 1999 14:105-114 DOI:10.1023/a:1008308128050 PMID:10427740
- Otomo, T., Ito, N., Kyogoku, Y., Yamazaki, T. NMR observation of selected segments in a larger protein: Central-segment isotope labeling through intein-mediated ligation Biochemistry 1999 38:16040-16044 DOI:10.1021/bi991902j PMID:10587426
- Yamazaki, T., Otomo, T., Oda, N., Kyogoku, Y., Uegaki, K., Ito, N., Ishino, Y., Nakamura, H. Segmental isotope labeling for protein NMR using peptide splicing Journal of the American Chemical Society 1998 120:5591-5592 DOI:10.1021/ja980776o
- Jeon, Y. H., Yamazaki, T., Otomo, T., Ishihama, A., Kyogoku, Y. Flexible linker in the RNA polymerase alpha subunit facilitates the independent motion of the C-terminal activator contact domain Journal of Molecular Biology 1997 267:953-962 DOI:10.1006/jmbi.1997.0902 PMID:9135123