recent publications
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academic article
- von Drygalski, A., Bhat, V., Gale, A. J., Averell, P. M., Cramer, T. J., Elias, D. J., Griffin, J. H., Mosnier, L. O. An engineered factor Va prevents bleeding induced by direct-acting oral anticoagulants by different mechanisms Blood Advances 2020 4:3716-3727 DOI:10.1182/bloodadvances.2020001699 PMID:32777068 PMCID:PMC7422119
- Mosnier, L. O. How much clotting is enough? Blood 2020 136:651-652 DOI:10.1182/blood.2020006443 PMID:32761220 PMCID:PMC7414588
- Heeb, M. J., Fernandez, J. A., Yamashita, A., McDowell, O. R., Guo, Z. H., Mosnier, L. O., Deguchi, H., Griffin, J. H. Activated protein C anticoagulant activity is enhanced by skeletal muscle myosin Haematologica 2020 105:E424-E427 DOI:10.3324/haematol.2019.242982 PMID:31857364 PMCID:PMC7395292
- Zhao, X. Y., Wilmen, A., Wang, D. L., Wang, X. Q., Bauzon, M., Kim, J. Y., Linden, L., Li, L., Egner, U., Marquardt, T., Moosmayer, D., Tebbe, J., et al. Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia Nature Communications 2020 11 DOI:10.1038/s41467-020-16720-9 PMID:32532974 PMCID:PMC7293249
- Yamashita, A., Zhang, Y. Q., Sanner, M. F., Griffin, J. H., Mosnier, L. O. C-terminal residues of activated protein C light chain contribute to its anticoagulant and cytoprotective activities Journal of Thrombosis and Haemostasis 2020 18:1027-1038 DOI:10.1111/jth.14756 PMID:32017367
- Zilberman-Rudenko, J., Deguchi, H., Shukla, M., Oyama, Y., Orje, J. N., Guo, Z. H., Wyseure, T., Mosnier, L. O., McCarty, O. J. T., Ruggeri, Z. M., Eckle, T., Griffin, J. H. Cardiac Myosin Promotes Thrombin Generation and Coagulation In Vitro and In Vivo Arteriosclerosis Thrombosis and Vascular Biology 2020 40:901-913 DOI:10.1161/atvbaha.120.313990 PMID:32102568 PMCID:PMC7135739
- Basu, S., Liang, H. P. H., Hernandez, I., Zogg, M., Fields, B., May, J., Ogoti, Y., Wyseure, T., Mosnier, L. O., Burns, R. T., Carlson, K., Weiler, H. Role of thrombomodulin expression on hematopoietic stem cells Journal of Thrombosis and Haemostasis 2020 DOI:10.1111/jth.14663 PMID:31628891
- Cooke, E. J., Wyseure, T., Zhou, J. Y., Gopal, S., Nasamran, C. A., Fisch, K. M., Manon-Jensen, T., Karsdal, M. A., Mosnier, L. O., von Drygalski, A. Mechanisms of vascular permeability and remodeling associated with hemarthrosis in factor VIII-deficient mice Journal of Thrombosis and Haemostasis 2019 DOI:10.1111/jth.14567 PMID:31301687
- Wyseure, T., Yang, T., Zhou, J. Y., Cooke, E. J., Wanko, B., Olmer, M., Agashe, R., Morodomi, Y., Behrendt, N., Lotz, M., Morser, J., von Drygalski, A., et al. TAFI deficiency causes maladaptive vascular remodeling after hemophilic joint bleeding JCI Insight 2019 4 DOI:10.1172/jci.insight.128379 PMID:31465300
- Mosnier, L. O. Activated protein C in neuroprotection and malaria Current Opinion in Hematology 2019 26:320-330 DOI:10.1097/moh.0000000000000528 PMID:31348046
- Lopez-Ramirez, M. A., Pham, A., Girard, R., Wyseure, T., Hale, P., Yamashita, A., Koskimaki, J., Polster, S., Saadat, L., Romero, I. A., Esmon, C. T., Lagarrigue, F., et al. Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice Blood 2019 133:193-204 DOI:10.1182/blood-2018-06-856062 PMID:30442679 PMCID:PMC6337879
- Adams, G. N., Sharma, B. K., Rosenfeldt, L., Frederick, M., Flick, M. J., Witte, D. P., Mosnier, L. O., Harmel-Laws, E., Steinbrecher, K. A., Palumbo, J. S. Protease-activated receptor-1 impedes prostate and intestinal tumor progression in mice Journal of Thrombosis and Haemostasis 2018 16:2258-2269 DOI:10.1111/jth.14277 PMID:30152921 PMCID:PMC6214773
- Wyseure, T., Cooke, E. J., Declerck, P. J., Behrendt, N., Meijers, J. C. M., von Drygalski, A., Mosnier, L. O. Defective TAFI activation in hemophilia A mice is a major contributor to joint bleeding Blood 2018 132:1593-1603 DOI:10.1182/blood-2018-01-828434 PMID:30026184 PMCID:PMC6182268
- Griffin, J. H., Zlokovic, B. V., Mosnier, L. O. Activated protein C, protease activated receptor 1, and neuroprotection Blood 2018 132:159-169 DOI:10.1182/blood-2018-02-769026 PMID:29866816 PMCID:PMC6043978
- Mosnier, L. O. Warfarin, a juggler's demise Blood 2018 131:2742-2743 DOI:10.1182/blood-2018-05-843151 PMID:29930151 PMCID:PMC6014355
- Cooke, E. J., Zhou, J. Y., Wyseure, T., Joshi, S., Bhat, V., Durden, D. L., Mosnier, L. O., von Drygalski, A. Vascular permeability and remodelling coincide with inflammatory and reparative processes after joint bleeding in factor VIII-deficient mice Thrombosis and Haemostasis 2018 118:1036-1047 DOI:10.1055/s-0038-1641755 PMID:29847841
- Sinha, R. K., Wang, Y., Zhao, Z., Xu, X., Burnier, L., Gupta, N., Fernandez, J. A., Martin, G., Kupriyanov, S., Mosnier, L. O., Zlokovic, B. V., Griffin, J. H. PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke Blood 2018 131:1163-1171 DOI:10.1182/blood-2017-10-810895 PMID:29343482 PMCID:PMC5855020
- Spronk, H. M. H., Padro, T., Siland, J. E., Prochaska, J. H., Winters, J., van der Wal, A. C., Posthuma, J. J., Lowe, G., d'Alessandro, E., Wenzel, P., Coenen, D. M., Reitsma, P. H., et al. Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis Thrombosis and Haemostasis 2018 118:229-250 DOI:10.1160/th17-07-0492 PMID:29378352
- Fernandez, J. A., Xu, X., Sinha, R. K., Mosnier, L. O., Sanner, M. F., Griffin, J. H. Activated protein C light chain provides an extended binding surface for its anticoagulant cofactor, protein S Blood Advances 2017 1:1423-1426 DOI:10.1182/bloodadvances.2017007005 PMID:29296783 PMCID:PMC5727852
- Griffin, J. H., Mosnier, L. O., Fernandez, J. A., Zlokovic, B. V. 2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis. Thrombotic stroke: neuroprotective therapy by recombinant-activated protein C Arteriosclerosis Thrombosis and Vascular Biology 2016 36:2143-2151 DOI:10.1161/atvbaha.116.308038 PMID:27758767 PMCID:PMC5119536
- Gale, A. J., Bhat, V., Pellequer, J. L., Griffin, J. H., Mosnier, L. O., Von Drygalski, A. Safety, stability and pharmacokinetic properties of (super)Factor Va, a novel engineered coagulation Factor V for treatment of severe bleeding Pharmaceutical Research 2016 33:1517-1526 DOI:10.1007/s11095-016-1895-3 PMID:26960296 PMCID:PMC4854778
- Mosnier, L. O., Lavstsen, T. The role of EPCR in the pathogenesis of severe malaria Thrombosis Research 2016 141:S46-S49 PMID:27207424
- Sinha, R. K., Yang, X. V., Fernandez, J. A., Xu, X., Mosnier, L. O., Griffin, J. H. Apolipoprotein E receptor 2 mediates activated protein C-induced endothelial Akt activation and endothelial barrier stabilization Arteriosclerosis Thrombosis and Vascular Biology 2016 36:518-524 DOI:10.1161/atvbaha.115.306795 PMID:26800564 PMCID:PMC4816599
- Cramer, T. J., Anderson, K., Navaz, K., Brown, J. M., Mosnier, L. O., von Drygalski, A. Heterozygous congenital Factor VII deficiency with the 9729de14 mutation, associated with severe spontaneous intracranial bleeding in an adolescent male Blood Cells Molecules and Diseases 2016 57:8-12 DOI:10.1016/j.bcmd.2015.11.004 PMID:26852649 PMCID:PMC4874642
- Bhat, V., von Drygalski, A., Gale, A. J., Griffin, J. H., Mosnier, L. O. Improved coagulation and haemostasis in haemophilia with inhibitors by combinations of superFactor Va and Factor VIIa Thrombosis and Haemostasis 2016 115:551-561 DOI:10.1160/th15-07-0525 PMID:26466980 PMCID:PMC4775351
- Wyseure, T., Mosnier, L. O., von Drygalski, A. Advances and challenges in hemophilic arthropathy Seminars in Hematology 2016 53:10-19 DOI:10.1053/j.seminhematol.2015.10.005 PMID:26805902 PMCID:PMC5034876
- Bouwens, E. A. M., Stavenuiter, F., Mosnier, L. O. Cell painting with an engineered EPCR to augment the protein C system Thrombosis and Haemostasis 2015 114:1144-1155 DOI:10.1160/th15-01-0079 PMID:26272345
- Petersen, J. E. V., Bouwens, E. A. M., Tamayo, I., Turner, L., Wang, C. W., Stins, M., Theander, T. G., Hermida, J., Mosnier, L. O., Lavstsen, T. Protein C system defects inflicted by the malaria parasite protein PfEMP1 can be overcome by a soluble EPCR variant Thrombosis and Haemostasis 2015 114:1038-1048 DOI:10.1160/th15-01-0018 PMID:26155776
- Bhat, V., Olmer, M., Joshi, S., Durden, D. L., Cramer, T. J., Barnes, R. F. W., Ball, S. T., Hughes, T. H., Silva, M., Luck, J. V., Moore, R. E., Mosnier, L. O., et al. Vascular remodeling underlies rebleeding in hemophilic arthropathy American Journal of Hematology 2015 90:1027-1035 DOI:10.1002/ajh.24133 PMID:26257191 PMCID:PMC4618067
- Griffin, J. H., Zlokovic, B. V., Mosnier, L. O. Activated protein C: biased for translation Blood 2015 125:2898-2907 DOI:10.1182/blood-2015-02-355974 PMID:25824691 PMCID:PMC4424414
- Stavenuiter, F., Mosnier, L. O. Noncanonical PAR3 activation by factor Xa identifies a novel pathway for Tie2 activation and stabilization of vascular integrity Blood 2014 124:3480-3489 DOI:10.1182/blood-2014-06-582775 PMID:25320242 PMCID:PMC4246042
- Mosnier, L. O., Zlokovic, B. V., Griffin, J. H. Cytoprotective-selective activated protein C therapy for ischaemic stroke Thrombosis and Haemostasis 2014 112:883-892 DOI:10.1160/th14-05-0448 PMID:25230930
- von Drygalski, A., Bhat, V., Gale, A. J., Burnier, L., Cramer, T. J., Griffin, J. H., Mosnier, L. O. An engineered Factor Va prevents bleeding induced by anticoagulant wt activated protein C PLoS One 2014 9:e104304 DOI:10.1371/journal.pone.0104304 PMID:25127130 PMCID:PMC4134195
- von Drygalski, A., Cramer, T. J., Bhat, V., Griffin, J. H., Gale, A. J., Mosnier, L. O. Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant Journal of Thrombosis and Haemostasis 2014 12:363-372 DOI:10.1111/jth.12489 PMID:24818532 PMCID:PMC4161283
- Mosnier, L. O. PolyP and APC fight a RAGEing battle Blood 2014 123:804-806 DOI:10.1182/blood-2013-12-541243 PMID:24505066 PMCID:PMC3916875
- Aird, W. C., Mosnier, L. O., Fairhurst, R. M. Plasmodium falciparum picks (on) EPCR Blood 2014 123:163-167 DOI:10.1182/blood-2013-09-521005 PMID:24246501 PMCID:PMC3888284
- Mosnier, L. O., Fernandez, J. A., Davis, T. P., Zlokovic, B. V., Griffin, J. H. Influence of the 3K3A-activated protein C variant on the plasma clot lysis activity of t-PA and of t-PA on the variant's anticoagulant activity Journal of Thrombosis and Haemostasis 2013 11:2059-2062 DOI:10.1111/jth.12400 PMID:24034518 PMCID:PMC3850769
- Wang, Y., Sinha, R. K., Mosnier, L. O., Griffin, J. H., Zlokovic, B. V. Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice Blood Cells Molecules and Diseases 2013 51:104-108 DOI:10.1016/j.bcmd2013.02.009 PMID:23541526
- Burnier, L., Mosnier, L. O. Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3 Blood 2013 122:807-816 DOI:10.1182/blood-2013-03-488957 PMID:23788139 PMCID:PMC3731934
- von Drygalski, A., Kolaitis, N. A., Bettencourt, R., Bergstrom, J., Kruse-Jarres, R., Quon, D. V., Wassel, C., Li, M. C., Waalen, J., Elias, D. J., Mosnier, L. O., Allison, M. Prevalence and risk factors for hypertension in hemophilia Hypertension 2013 62:209-215 DOI:10.1161/hypertensionaha.113.01174 PMID:23630949
- Bouwens, E. A. M., Stavenuiter, F., Mosnier, L. O. Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway Journal of Thrombosis and Haemostasis 2013 11:242-253 DOI:10.1111/jth.12247 PMID:23809128 PMCID:PMC3713536
- von Drygalski, A., Furlan-Freguia, C., Ruf, W., Griffin, J. H., Mosnier, L. O. Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor Arteriosclerosis, Thrombosis, and Vascular Biology 2013 33:769-776 DOI:10.1161/atvbaha.112.301082 PMID:23393392
- Stavenuiter, F., Bouwens, E. A., Mosnier, L. O. Down-regulation of the clotting cascade by the protein C pathway Hematology Education 2013 7:365-374 PMID:24741378 PMCID:PMC3985519
- Mosnier, L. O., Sinha, R. K., Burnier, L., Bouwens, E. A., Griffin, J. H. Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46 Blood 2012 120:5237-5246 DOI:10.1182/blood-2012-08-452169 PMID:23149848 PMCID:PMC3537315
- von Drygalski, A., Furlan-Freguia, C., Mosnier, L. O., Yegneswaran, S., Ruf, W., Griffin, J. H. Infrared fluorescence for vascular barrier breach in vivo - a novel method for quantitation of albumin efflux Thrombosis and Haemostasis 2012 108:981-991 DOI:10.1160/th12-03-0196 PMID:23052565 PMCID:PMC3597782
- Griffin, J. H., Zlokovic, B. V., Mosnier, L. O. Protein c anticoagulant and cytoprotective pathways International Journal of Hematology 2012 95:333-345 DOI:10.1007/s12185-012-1059-0 PMID:22477541 PMCID:PMC3413316
- Bouwens, E. A., Mosnier, L. O. EPCR encryption induces cellular APC resistance Blood 2012 119:2703-2705 DOI:10.1182/blood-2012-01-400762 PMID:22442333
- Mosnier, L. O. A knockout for knockin Blood 2011 117:6058-6060 DOI:10.1182/blood-2011-04-345553
- Mosnier, L. O. Platelet factor 4 inhibits thrombomodulin-dependent activation of thrombin-activatable fibrinolysis inhibitor (tafi) by thrombin Journal of Biological Chemistry 2011 286:502-510 DOI:10.1074/jbc.M110.147959 PMID:21041299 PMCID:PMC3013010
- Fernandes, N., Mosnier, L. O., Tonnu, L., Heeb, M. J. Zn(2+)-containing protein S inhibits extrinsic factor X-activating complex independently of tissue factor pathway inhibitor Journal of Thrombosis and Haemostasis 2010 8:1976-1985 DOI:10.1111/j.1538-7836.2010.03919.x PMID:20492471 PMCID:PMC2955986
- Mosnier, L. O., Zampolli, A., Kerschen, E. J., Schuepbach, R. A., Banerjee, Y., Fernandez, J. A., Yang, X. V., Riewald, M., Weiler, H., Ruggeri, Z. M., Griffin, J. H. Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant Blood 2009 113:5970-5978 DOI:10.1182/blood-2008-10-183327 PMID:19244160 PMCID:PMC2700330
- Yang, X. V., Banerjee, Y., Fernandez, J. A., Deguchi, H., Xu, X., Mosnier, L. O., Urbanus, R. T., de Groot, P. G., White-Adams, T. C., McCarty, O. J. T., Griffin, J. H. Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells Proceedings of the National Academy of Sciences of the United States of America 2009 106:274-279 DOI:10.1073/pnas.0807594106 PMID:19116273 PMCID:PMC2629184
- Mosnier, L. O., Yang, X. V., Griffin, J. H. Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions Journal of Biological Chemistry 2007 282:33022-33033 DOI:10.1074/jbc.M705824200 PMID:17872949
- Kerschen, E. J., Fernandez, J. A., Cooley, B. C., Yang, X. V., Sood, R., Mosnier, L. O., Castellino, F. J., Mackman, N., Griffin, J. H., Weiler, H. Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C Journal of Experimental Medicine 2007 204:2439-2448 DOI:10.1084/jem.20070404 PMID:17893198 PMCID:PMC2118455
- Griffin, J. H., Fernandez, J. A., Gale, A. J., Mosnier, L. O. Activated protein C Journal of Thrombosis and Haemostasis 2007 5:73-80 DOI:10.1111/j.1538-7836.2007.02491.x PMID:17635713
- Mosnier, L. O., Zlokovic, B. V., Griffin, J. H. The cytoprotective protein C pathway Blood 2007 109:3161-3172 DOI:10.1182/blood-2006-09-003004 PMID:17110453
- Mosnier, L. O., Bouma, B. N. Regulation of fibrinolysis by thrombin activatable fibrinolysis inhibitor, an unstable carboxypeptidase b that unites the pathways of coagulation and fibrinolysis Arteriosclerosis, Thrombosis, and Vascular Biology 2006 26:2445-2453 DOI:10.1161/01.ATV.0000244680.14653.9a PMID:16960106
- Mosnier, L. O., Griffin, J. H. Protein C anticoagulant activity in relation to anti-inflammatory and anti-apoptotic activities Frontiers in Bioscience 2006 11:2381-2399 DOI:10.2741/1977 PMID:16720321
- Feistritzer, C., Schuepbach, R. A., Mosnier, L. O., Bush, L. A., Di Cera, E., Griffin, J. H., Riewald, M. Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells Journal of Biological Chemistry 2006 281:20077-20084 DOI:10.1074/jbc.M600506200 PMID:16709569
- Griffin, J. H., Fernandez, J. A., Mosnier, L. O., Liu, D., Cheng, T., Guo, H., Zlokovic, B. V. The promise of protein C Blood Cells Molecules and Diseases 2006 36:211-216 DOI:10.1016/j,bcmd.2005.12.023 PMID:16464623
- Bouma, B. N., Mosnier, L. O. Thrombin activatable fibrinolysis inhibitor (tafi) - how does thrombin regulate fibrinolysis? Annals of Medicine 2006 38:378-388 DOI:10.1080/07853890600852898 PMID:17008302
- Mosnier, L. O., Gale, A. J., Yegneswaran, S., Griffin, J. H. Activated protein C variants with normal cytoprotective but reduced anticoagulant activity Blood 2004 104:1740-1744 DOI:10.1182/blood-2004-01-0110 PMID:15178575
- Mosnier, L. O., Griffin, J. H. Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor Biochemical Journal 2003 373:65-70 DOI:10.1042/bj20030341 PMID:12683950
- Mosnier, L. O., Buijtenhuijs, P., Marx, P. F., Meijers, J. C. M., Bouma, B. N. Identification of thrombin activatable fibrinolysis inhibitor (tafi) in human platelets Blood 2003 101:4844-4846 DOI:10.1182/blood-2002-09-2944 PMID:12595308
- Reijerkerk, A., Mosnier, L. O., Kranenburg, O., Bouma, B. N., Carmeliet, P., Drixler, T., Meijers, J. C. M., Voest, E. E., Gebbink, Mfbg Amyloid endostatin induces endothelial cell detachment by stimulation of the plasminogen activation system Molecular Cancer Research 2003 1:561-568 PMID:12805403
- Bouma, B. N., Mosnier, L. O. Thrombin activatable fibrinolysis inhibitor (tafi) at the interface between coagulation and fibrinolysis Pathophysiology of Haemostasis and Thrombosis 2003 33:375-381 DOI:10.1159/000083832 PMID:15692247
- Lisman, T., Mosnier, L. O., Lambert, T., Mauser-Bunschoten, E. P., Meijers, J. C. M., Nieuwenhuis, H. K., de Groot, P. G. Inhibition of fibrinolysis by recombinant factor viia in plasma from patients with severe hemophilia a Blood 2002 99:175-179 DOI:10.1182/blood.V99.1.175 PMID:11756168
- Mosnier, L. O., Elisen, Mglm, Bouma, B. N., Meijers, J. C. M. Protein c inhibitor regulates the thrombin-thrombomodulin complex in the up- and down regulation of tafi activation Thrombosis and Haemostasis 2001 86:1057-1064 PMID:11686324
- Mosnier, L. O., Lisman, T., van den Berg, H. M., Nieuwenhuis, H. K., Meijers, J. C. M., Bouma, B. N. The defective down regulation of fibrinolysis in haemophilia a can be restored by increasing the tafi plasma concentration Thrombosis and Haemostasis 2001 86:1035-1039 PMID:11686321
- Mosnier, L. O., Meijers, J. C. M., Bouma, B. N. The role of protein s in the activation of thrombin activatable fibrinolysis inhibitor (tafi) and regulation of fibrinolysis Thrombosis and Haemostasis 2001 86:1040-1046 PMID:11686322
- Lisman, T., Leebeek, F. W. G., Mosnier, L. O., Bouma, B. N., Meijers, J. C. M., Janssen, H. L. A., Nieuwenhuis, H. K., De Groot, P. G. Thrombin-activatable fibrinolysis inhibitor deficiency in cirrhosis is not associated with increased plasma fibrinolysis Gastroenterology 2001 121:131-139 DOI:10.1053/gast.2001.25481 PMID:11438502
- Bouma, B. N., Marx, P. F., Mosnier, L. O., Meijers, J. C. M. Thrombin-activatable fibrinolysis inhibitor (tafi, plasma procarboxypeptidase b, procarboxypeptidase r, procarboxypeptidase u) Thrombosis Research 2001 101:329-354 DOI:10.1016/s0049-3848(00)00411-4 PMID:11297751
- Rebel, H., Mosnier, L. O., Berg, R. J. W., Westerman-de Vries, A., van Steeg, H., van Kranen, H. J., de Gruijl, F. R. Early p53-positive foci as indicators of tumor risk in ultraviolet-exposed hairless mice: Kinetics of induction, effects of DNA repair deficiency, and p53 heterozygosity Cancer Research 2001 61:977-983 PMID:11221893
- Mosnier, L. O., Meijers, J. C. M., Bouma, B. N. Regulation of fibrinolysis in plasma by tafi and protein c is dependent on the concentration of thrombomodulin Thrombosis and Haemostasis 2001 85:5-11 PMID:11204587
- Meijers, J. C. M., Oudijk, E. J. D., Mosnier, L. O., Bos, R., Bouma, B. N., Nieuwenhuis, H. K., Fijnheer, R. Reduced activity of tafi (thrombin-activatable fibrinolysis inhibitor) in acute promyelocytic leukaemia British Journal of Haematology 2000 108:518-523 DOI:10.1046/j.1365-2141.2000.01890.x PMID:10759708
- Bouma, B. N., Mosnier, L. O., Meijers, J. C. M., Griffin, J. H. Factor XI dependent and independent activation of thrombin activatable fibrinolysis inhibitor (TAFI) in plasma associated with clot formation Thrombosis and Haemostasis 1999 82:1703-1708 PMID:10613658
- Mosnier, L. O., von dem Borne, P. A. K., Meijers, J. C. M., Bouma, B. N. Plasma tafi levels influence the clot lysis time in healthy individuals in the presence of an intact intrinsic pathway of coagulation Thrombosis and Haemostasis 1998 80:829-835 PMID:9843179
- Minnema, M. C., Friederich, P. W., Levi, M., von dem Borne, P. A. K., Mosnier, L. O., Meijers, J. C. M., Biemond, B. J., Hack, C. E., Bouma, B. N., ten Cate, H. Enhancement of rabbit jugular vein thrombolysis by neutralization of factor xi - in vivo evidence for a role of factor xi as an anti-fibrinolytic factor Journal of Clinical Investigation 1998 101:10-14 DOI:10.1172/jci781 PMID:9421460
- vondemBorne, P. A. K., Mosnier, L. O., Tans, G., Meijers, J. C. M., Bouma, B. N. Factor xi activation by meizothrombin: Stimulation by phospholipid vesicles containing both phosphatidylserine and phosphatidylethanolamine Thrombosis and Haemostasis 1997 78:834-839 PMID:9268180