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Miller, Courtney
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Miller, Courtney

Faculty Member
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Positions

  • 2017 - Associate Professor (with tenure), Molecular Medicine , Scripps Research
  • 2014 - Associate Professor (Joint Appointment), Neuroscience , Scripps Research
  • 2009 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • Affiliate Research Assistant Professor, Department of Biological Sciences, Florida Atlantic University
  • Postdoctoral Fellow with Dr. David Sweatt, The University of Alabama at Birmingham , The University of Alabama System
  • Scientific Director, Evelyn F. McKnight Brain Institute, The University of Alabama at Birmingham , The University of Alabama System
  • Instructor, Department of Neurobiology, The University of Alabama at Birmingham , The University of Alabama System
  • 2009 - 2013 Assistant Professor, Metabolism and Aging , Scripps Research
Dr. Courtney Miller is working to develop novel therapeutics for the treatment of memory disorders by targeting the epigenetic and synaptic contributors.

Research Areas research areas

  • Alzheimer (UMLS)

Contact

  • cmiller@scripps.edu

Websites

  • Courtney Miller, Ph.D.
  • Publications
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Publications

recent publications
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  • Publications without PubMed PMIDs

  • academic article

    • Llamosas, N., Michaelson, S. D., Vaissiere, T., Rojas, C., Miller, C. A., Rumbaugh, G. Syngap1 regulates experience-dependent cortical ensemble plasticity by promoting in vivo excitatory synapse strengthening Proceedings of the National Academy of Sciences of the United States of America  2021 118  DOI:10.1073/pnas.2100579118  PMID:34404727  PMCID:PMC8403968
    • Hafenbreidel, M., Miller, C. A. A role for amygdala endocannabinoid signaling in reconsolidation of cocaine-associated memories Neuropsychopharmacology  2021 46:1549-1550  DOI:10.1038/s41386-020-00951-x  PMID:33589777  PMCID:PMC8280214
    • Radnai, L., Surman, M., Hafenbreidel, M., Young, E. J., Stremel, R. F., Lin, L., Bdiri, B., Pasetto, P., Jin, X. M., Geedy, M., Partridge, J. R., Patel, A., et al. Discovery of Selective Inhibitors for In Vitro and In Vivo Interrogation of Skeletal Myosin II ACS Chemical Biology  2021 16:2164-2173  DOI:10.1021/acschembio.1c00067  PMID:34558887
    • Sillivan, S. E., Miller, C. A. Targeting persistent stress-enhanced memory through microRNAs Neuropsychopharmacology  2021  DOI:10.1038/s41386-020-00816-3  PMID:32843704
    • Llamosas, N., Arora, V., Vij, R., Kilinc, M., Bijoch, L., Rojas, C., Reich, A., Sridharan, B., Willems, E., Piper, D. R., Scampavia, L., Spicer, T. P., et al. SYNGAP1 Controls the Maturation of Dendrites, Synaptic Function, and Network Activity in Developing Human Neurons Journal of Neuroscience  2020 40:7980-7994  DOI:10.1523/jneurosci.1367  PMID:32887745  PMCID:PMC7548701
    • Sillivan, S. E., Jamieson, S., de Nijs, L., Jones, M., Snijders, C., Klengel, T., Joseph, N. F., Krauskopf, J., Kleinjans, J., Vinkers, C. H., Boks, M. P. M., Geuze, E., et al. MicroRNA regulation of persistent stress-enhanced memory Molecular Psychiatry  2020 25:965-976  DOI:10.1038/s41380-019-0432-2  PMID:31142820  PMCID:PMC6883139
    • Young, E. J., Lin, H., Kamenecka, T. M., Rumbaugh, G., Miller, C. A. Methamphetamine learning induces persistent and selective nonmuscle myosin II-dependent spine motility in the basolateral amygdala Journal of Neuroscience  2020 40:2695-2707  DOI:10.1523/jneurosci.2182-19.2020  PMID:32066582  PMCID:PMC7096141
    • Blouin, A. M., Pisupati, S., Hoffer, C. G., Hafenbreidel, M., Jamieson, S. E., Rumbaugh, G., Miller, C. A. Social stress-potentiated methamphetamine seeking Addiction Biology  2019 24:958-968  DOI:10.1111/adb.12666  PMID:30105771  PMCID:PMC6375809
    • Radnai, L., Stremel, R. F., Sellers, J. R., Rumbaugh, G., Miller, C. A. A semi-high-throughput adaptation of the NADH-coupled ATPase assay for screening small molecule inhibitors Jove-Journal of Visualized Experiments  2019  DOI:10.3791/60017  PMID:31475972
    • Creson, T. K., Rojas, C., Hwaun, E., Vaissiere, T., Kilinc, M., Jimenez-Gomez, A., Holder, J. L., Tang, J., Colgin, L. L., Miller, C. A., Rumbaugh, G. Re-expression of SynGAP protein in adulthood improves translatable measures of brain function and behavior Elife  2019 8  DOI:10.7554/eLife.46752  PMID:31025938  PMCID:PMC6504227
    • Sillivan, S. E., Jones, M. E., Jamieson, S., Rumbaugh, G., Miller, C. A. Bioinformatic analysis of long-lasting transcriptional and translational changes in the basolateral amygdala following acute stress PLoS One  2019 14  DOI:10.1371/journal.pone.0209846  PMID:30629705  PMCID:PMC6328204
    • Michaelson, S. D., Ozkan, E. D., Aceti, M., Maity, S., Llamosas, N., Weldon, M., Mizrachi, E., Vaissiere, T., Gaffield, M. A., Christie, J. M., Holder, J. L., Miller, C. A., et al. SYNGAP1 heterozygosity disrupts sensory processing by reducing touch-related activity within somatosensory cortex circuits Nature Neuroscience  2018 21:1-13  DOI:10.1038/s41593-018-0268-0  PMID:30455457
    • Briggs, S. B., Hafenbreidel, M., Young, E. J., Rumbaugh, G., Miller, C. A. The role of nonmuscle myosin II in polydrug memories and memory reconsolidation Learning & Memory  2018 25:391-398  DOI:10.1101/lm.046763.117  PMID:30115760  PMCID:PMC6097765
    • Furth, D., Vaissiere, T., Tzortzi, O., Xuan, Y., Martin, A., Lazaridis, I., Spigolon, G., Fisone, G., Tomer, R., Deisseroth, K., Carlen, M., Miller, C. A., et al. An interactive framework for whole-brain maps at cellular resolution Nature Neuroscience  2018 21:139-149  DOI:10.1038/s41593-017-0027-7  PMID:29203898
    • Sillivan, S. E., Joseph, N. F., Jamieson, S., King, M. L., Chevere-Torres, I., Fuentes, I., Shumyatsky, G. P., Brantley, A. F., Rumbaugh, G., Miller, C. A. Susceptibility and resilience to posttraumatic stress disorder-like behaviors in inbred mice Biological Psychiatry  2017 82:924-933  DOI:10.1016/j.biopsych.2017.06.030  PMID:28778658  PMCID:PMC5683920
    • Girardet, C., Mavrikaki, M. M., Stevens, J. R., Miller, C. A., Marks, D. L., Butler, A. A. Melanocortin-3 receptors expressed in Nkx2.1(+ve) neurons are sufficient for controlling appetitive responses to hypocaloric conditioning Scientific Reports  2017 7  DOI:10.1038/srep44444  PMID:28294152  PMCID:PMC5353610
    • Young, E. J., Briggs, S. B., Rumbaugh, G., Miller, C. A. Nonmuscle myosin II inhibition disrupts methamphetamine-associated memory in females and adolescents Neurobiology of Learning and Memory  2017 139:109-116  DOI:10.1016/j.nlm.2017.01.001  PMID:28082169  PMCID:PMC5334279
    • Briggs, S. B., Blouin, A. M., Young, E. J., Rumbaugh, G., Miller, C. A. Memory disrupting effects of nonmuscle myosin II inhibition depend on the class of abused drug and brain region Learning & Memory  2017 24:70-75  DOI:10.1101/lm.043976.116  PMID:28096495  PMCID:PMC5238718
    • Blouin, A. M., Sillivan, S. E., Joseph, N. F., Miller, C. A. The potential of epigenetics in stress-enhanced fear learning models of PTSD Learning & Memory  2016 23:576-586  DOI:10.1101/lm.040485.115  PMID:27634148  PMCID:PMC5026205
    • Mavrikaki, M., Girardet, C., Kern, A., Brantley, A. F., Miller, C. A., Macarthur, H., Marks, D. L., Butler, A. A. Melanocortin-3 receptors in the limbic system mediate feeding-related motivational responses during weight loss Molecular Metabolism  2016 5:566-579  DOI:10.1016/j.molmet.2016.05.002  PMID:27408780  PMCID:PMC4921936
    • Young, E. J., Blouin, A. M., Briggs, S. B., Sillivan, S. E., Lin, L., Cameron, M. D., Rumbaugh, G., Miller, C. A. Nonmuscle myosin IIB as a therapeutic target for the prevention of relapse to methamphetamine use Molecular Psychiatry  2016 21:615-623  DOI:10.1038/mp.2015.103  PMID:26239291  PMCID:PMC4740255
    • Mediouni, S., Marcondes, M. C. G., Miller, C., McLaughlin, J. P., Valente, S. T. The cross-talk of HIV-1 Tat and methamphetamine in HIV-associated neurocognitive disorders Frontiers in Microbiology  2015 6:1164  DOI:10.3389/fmicb.2015.01164  PMID:26557111  PMCID:PMC4615951
    • Rumbaugh, G., Sillivan, S. E., Ozkan, E. D., Rojas, C. S., Hubbs, C. R., Kilgore, M., Kudugunti, S., Puthanveettil, S. V., Sweatt, J. D., Rusche, J., Miller, C. A. Pharmacological selectivity within class I histone deacetylases predicts effects on synaptic function and memory rescue Neuropsychopharmacology  2015 40:2307-2316  DOI:10.1038/npp.2015.93  PMID:25837283  PMCID:PMC4538358
    • Ozkan, E. D., Creson, T. K., Rojas, C. S., Hubbs, C. R., McGuire, M. N., Kakad, P. P., Miller, C. A., Rumbaugh, G. Input-specific regulation of hippocampal circuit maturation by non-muscle myosin IIB Journal of Neurochemistry  2015 134:429-444  DOI:10.1111/jnc.13146  PMID:25931194  PMCID:PMC4496335
    • Creson, T. K., Vaissiere, T., Rojas, C., Huang, W. C., Wang, Y. X., Petralia, R. S., Page, D. T., Miller, C. A., Rumbaugh, G. Syngap1 haploinsufficiency damages a postnatal critical period of pyramidal cell structural maturation linked to cortical circuit assembly Biological Psychiatry  2015 77:805-815  DOI:10.1016/j.biopsych.2014.08.001  PMID:25444158  PMCID:PMC4326604
    • Young, E. J., Briggs, S. B., Miller, C. A. The actin cytoskeleton as a therapeutic target for the prevention of relapse to methamphetamine use CNS & Neurological Disorders-Drug Targets  2015 14:731-737  PMID:26022262  PMCID:PMC4641563
    • Aguilar-Valles, A., Vaissiere, T., Griggs, E. M., Mikaelsson, M. A., Takacs, I. F., Young, E. J., Rumbaugh, G., Miller, C. A. Methamphetamine-associated memory is regulated by a writer and an eraser of permissive histone methylation Biological Psychiatry  2014 76:57-65  DOI:10.1016/j.biopsych.2013.09.014  PMID:24183790  PMCID:PMC4024089
    • Young, E. J., Griggs, E. M., Fuchs, R. A., Zigmond, Z., Rumbaugh, G., Miller, C. A. Selective, retrieval-independent disruption of methamphetamine-associated memory by actin depolymerization Biological Psychiatry  2014 75:96-104  DOI:10.1016/j.biopsych.2013.07.036  PMID:24012327  PMCID:PMC4023488
    • Clement, J. P., Ozkan, E. D., Miller, C. A., Rumbaugh, G. SYNGAP1 links the maturation rate of excitatory synapses to the duration of critical-period synaptic plasticity Journal of Neuroscience  2013 33:10447-10452  DOI:10.1523/jneurosci.0765-13.2013  PMID:23785156  PMCID:PMC3685838
    • Griggs, E. M., Young, E. J., Rumbaugh, G., Miller, C. A. MicroRNA-182 regulates amygdala-dependent memory formation Journal of Neuroscience  2013 33:1734-1740  DOI:10.1523/jneurosci.2873-12.2013  PMID:23345246  PMCID:PMC3711533
    • Clement, J. P., Creson, T. K., Ozkan, E. D., Shi, Y. L., Reish, N. J., Almonte, A. G., Miller, B. H., Wiltgen, B. J., Miller, C. A., Xu, X., Rumbaugh, G. Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses Cell  2012 151:709-723  DOI:10.1016/j.cell.2012.08.045  PMID:23141534  PMCID:PMC3500766
    • Gavin, C. F., Rubio, M. D., Young, E., Miller, C., Rumbaugh, G. Myosin II motor activity in the lateral amygdala is required for fear memory consolidation Learning & Memory  2012 19:9-14  DOI:10.1101/lm.024042.111  PMID:22174310  PMCID:PMC3246591
    • Rubio, M. D., Johnson, R., Miller, C. A., Huganir, R. L., Rumbaugh, G. Regulation of synapse structure and function by distinct myosin ll motors Journal of Neuroscience  2011 31:1448-1460  DOI:10.1523/jneurosci.3294-10.2011  PMID:21273429  PMCID:PMC3074980
    • Xie, Z., Cahill, M. E., Radulovic, J., Wang, J., Campbell, S. L., Miller, C. A., Sweatt, J. D., Penzes, P. Hippocampal phenotypes in kalirin-deficient mice Molecular and Cellular Neuroscience  2011 46:45-54  DOI:10.1016/j.mcn.2010.08.005  PMID:20708080  PMCID:PMC3576140
    • Rumbaugh, G., Miller, C. A. Epigenetic changes in the brain: measuring global histone modifications Methods in Molecular Biology  2011 670:263-274  DOI:10.1007/978-1-60761-744-0_18  PMID:20967596  PMCID:PMC3235043
    • Rex, C. S., Gavin, C. F., Rubio, M. D., Kramar, E. A., Chen, L. Y., Jia, Y. S., Huganir, R. L., Muzyczka, N., Gall, C. M., Miller, C. A., Lynch, G., Rumbaugh, G. Myosin IIb regulates actin dynamics during synaptic plasticity and memory formation Neuron  2010 67:603-617  DOI:10.1016/j.neuron.2010.07.016  PMID:20797537  PMCID:PMC2929390
    • Polter, A., Beurel, E., Yang, S. F., Garner, R., Song, L., Miller, C. A., Sweatt, J. D., McMahon, L., Bartolucci, A. A., Li, X. H., Jope, R. S. Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances Neuropsychopharmacology  2010 35:1761-1774  DOI:10.1038/npp.2010.43  PMID:20357757  PMCID:PMC2891528
    • Miller, C. A., Gavin, C. F., White, J. A., Parrish, R. R., Honasoge, A., Yancey, C. R., Rivera, I. M., Rubio, M. D., Rumbaugh, G., Sweatt, J. D. Cortical DNA methylation maintains remote memory Nature Neuroscience  2010 13:664-666  DOI:10.1038/nn.2560  PMID:20495557  PMCID:PMC3043549
    • Kilgore, M., Miller, C. A., Fass, D. M., Hennig, K. M., Haggarty, S. J., Sweatt, J. D., Rumbaugh, G. Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease Neuropsychopharmacology  2010 35:870-880  DOI:10.1038/npp.2009.197  PMID:20010553  PMCID:PMC3055373
    • Yuskaitis, C. J., Mines, M. A., King, M. K., Sweatt, J. D., Miller, C. A., Jope, R. S. Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of fragile x syndrome Biochemical Pharmacology  2010 79:632-646  DOI:10.1016/j.bcp.2009.09.023  PMID:19799873  PMCID:PMC2810609
    • Yokoi, F., Dang, M. T., Miller, C. A., Marshall, A. G., Campbell, S. L., Sweatt, J. D., Li, Y. Q. Increased c-fos expression in the central nucleus of the amygdala and enhancement of cued fear memory in dyt1 delta gag knock-in mice Neuroscience Research  2009 65:228-235  DOI:10.1016/j.neures.2009.07.004  PMID:19619587  PMCID:PMC2757526
    • Guo, X. C., Hamilton, P. J., Reish, N. J., Sweatt, J. D., Miller, C. A., Rumbaugh, G. Reduced expression of the NMDA receptor-interacting protein SynGAP causes behavioral abnormalities that model symptoms of schizophrenia Neuropsychopharmacology  2009 34:1659-1672  DOI:10.1038/npp.2008.223  PMID:19145222  PMCID:PMC3690772
    • Cahill, M. E., Xie, Z., Day, M., Barbolina, M. V., Miller, C. A., Weiss, C., Radulovic, J., Sweatt, J. D., Disterhoft, J. F., Surmeier, D. J., Penzes, P. Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes Proceedings of the National Academy of Sciences of the United States of America  2009 106:13058-13063  DOI:10.1073/pnas.0904636106  PMID:19625617  PMCID:PMC2722269
    • Miller, C. A., Campbell, S. L., Sweatt, J. D. DNA methylation and histone acetylation work in concert to regulate memory formation and synaptic plasticity Neurobiology of Learning and Memory  2008 89:599-603  DOI:10.1016/j.nlm.2007.07.016  PMID:17881251  PMCID:PMC2430891
    • Miller, C. A., Sweatt, J. D. Covalent modification of DNA regulates memory formation Neuron  2007 53:857-869  DOI:10.1016/j.neuron.2007.02.022  PMID:17359920
    • Miller, C. A., Sweatt, J. D. Amnesia or retrieval deficit? Implications of a molecular approach to the question of reconsolidation Learning & Memory  2006 13:498-505  DOI:10.1101/lm.304606  PMID:17015846
    • Levenson, J. M., Roth, T. L., Lubin, F. D., Miller, C. A., Huang, I. C., Desai, P., Malone, L. M., Sweatt, J. D. Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus Journal of Biological Chemistry  2006 281:15763-15773  DOI:10.1074/jbc.M511767200  PMID:16606618
    • Miller, C. A., Marshall, J. F. Molecular substrates for retrieval and reconsolidation of cocaine-associated contextual memory Neuron  2005 47:873-884  DOI:10.1016/j.neuron.2005.08.006  PMID:16157281
    • Miller, C. A., Marshall, J. F. Altered Fos expression in neural pathways underlying cue-elicited drug seeking in the rat European Journal of Neuroscience  2005 21:1385-1393  DOI:10.1111/j.1460-9568.2005.03974.x  PMID:15813948
    • Miller, C. A., Marshall, J. F. Altered prelimbic cortex output during cue-elicited drug seeking Journal of Neuroscience  2004 24:6889-6897  DOI:10.1523/jneurosci.1685-04.2004  PMID:15295023

featured in

  • Courtney Miller's Compass  Newsletter
  • Nationally Known Memory Researcher Appointed to Metabolism and Aging Faculty at Scripps Florida  Newsletter
  • Scripps Research Institute Study Suggests Possibility of Selectively Erasing Unwanted Memories  News Release
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Research

research overview

  • Our laboratory is working to understand the neurobiological underpinnings of memory disorders, with the goal of developing novel therapeutics.
    Our research focuses on the contribution of epigenetic mechanisms to two serious health issues, drug addiction and age-related memory decline. Interestingly, while addiction and mild cognitive impairment represent opposing disorders of memory, both are aberrations of a normal cognitive process. The neurochemical alterations produced by a drug of abuse, such as cocaine, initiate a cascade of events that produce aberrantly strong memories. On the other hand, the poorly understood events of aging result in weakened memory traces. This bidirectionality demonstrates that memories are susceptible to modulation by any number of processes capable of influencing the CNS.
    Thus, we believe that by understanding the dynamic and stable nature of epigenetic mechanisms in the brain, along with their transcriptional consequences, we can better our understanding of the memory processes we take for granted every day. For example, how does a dynamic brain stably maintain memories beyond the initial functional and structural changes? How can we speed up the process of extinguishing a memory in addicted individuals, while preventing this from happening in older adults? How does the brain update memories? We are working to address these questions using a variety of animal behavioral models in combination with techniques ranging from viral delivery of shRNAs in vivo to bisulfite pyrosequencing for visualizing specific changes in cytosine methylation.
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Teaching

advisees

  • graduate advising relationship

    • Joseph, Nadine, Ph.D.  candidate, 2015 -
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Background

education and training

  • Ph.D. in Neurobiology & Behavior, University of California, Irvine , Center for the Neurobiology of Learning & Memory, with Dr. John Marshall 2005
  • B.S. in Biopsychology, University of California, Santa Barbara 1999

awards and honors

  • Presidential Early Career Award for Scientists and Engineers, conferred by National Science and Technology Council, 2016
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Contact

full name

  • Courtney Anne Miller

geographic location

  • Scripps Florida 
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Identity

ORCID iD

  • ORCID iD http://orcid.org/0000-0001-8628-4902

ResearcherID (Thomson Reuters)

  • E-8651-2010

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