recent publications
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academic article
- Tikunov, A. P., Shim, Y. S., Bhattarai, N., Siler, S. Q., Soldatow, V., LeCluyse, E. L., McDunn, J. E., Watkins, P. B., Macdonald, J. M. Dose-response in a high density three-dimensional liver device with real-time bioenergetic and metabolic flux quantification Toxicology in Vitro 2017 45:119-127 DOI:10.1016/j.tiv.2017.08.021 PMID:28867505
- Tsalik, E. L., Willig, L. K., Rice, B. J., van Velkinburgh, J. C., Mohney, R. P., McDunn, J. E., Dinwiddie, D. L., Miller, N. A., Mayer, E. S., Glickman, S. W., Jaehne, A. K., Glew, R. H., et al. Renal systems biology of patients with systemic inflammatory response syndrome Kidney International 2015 88:804-814 DOI:10.1038/ki.2015.150 PMID:25993322 PMCID:PMC4591107
- Wittmann, B. M., Stirdivant, S. M., Mitchell, M. W., Wulff, J. E., McDunn, J. E., Li, Z., Dennis-Barrie, A., Neri, B. P., Milburn, M. V., Lotan, Y., Wolfert, R. L. Bladder cancer biomarker discovery using global metabolomic profiling of urine PLoS One 2014 9 DOI:10.1371/journal.pone.0115870 PMID:25541698 PMCID:PMC4277370
- Garvey, S. M., Dugle, J. E., Kennedy, A. D., McDunn, J. E., Kline, W., Guo, L., Guttridge, D. C., Pereira, S. L., Edens, N. K. Metabolomic profiling reveals severe skeletal muscle group-specific perturbations of metabolism in aged FBN rats Biogerontology 2014 15:217-232 DOI:10.1007/s10522-014-9492-5 PMID:24652515 PMCID:PMC4019835
- Zeng, C., Vangveravong, S., McDunn, J. E., Hawkins, W. G., Mach, R. H. Sigma-2 receptor ligand as a novel method for delivering a SMAC mimetic drug for treating ovarian cancer British Journal of Cancer 2013 109:2368-2377 DOI:10.1038/bjc.2013.593 PMID:24104966 PMCID:PMC3817331
- McDunn, J. E., Li, Z., Adam, K. P., Neri, B. P., Wolfert, R. L., Milburn, M. V., Lotan, Y., Wheeler, T. M. Metabolomic signatures of aggressive prostate cancer Prostate 2013 73:1547-1560 DOI:10.1002/pros.22704 PMID:23824564
- Hunter, R. A., Privett, B. J., Henley, W. H., Breed, E. R., Liang, Z., Mittal, R., Yoseph, B. P., McDunn, J. E., Burd, E. M., Coopersmith, C. M., Ramsey, J. M., Schoenfisch, M. H. Microfluidic amperometric sensor for analysis of nitric oxide in whole blood Analytical Chemistry 2013 85:6066-6072 DOI:10.1021/ac400932s PMID:23692300 PMCID:PMC3712765
- Szabova, L., Yin, C., Bupp, S., Guerin, T. M., Schlomer, J. J., Householder, D. B., Baran, M. L., Yi, M., Song, Y., Sun, W., McDunn, J. E., Martin, P. L., et al. Perturbation of Rb, p53, and Brca1 or Brca2 cooperate in inducing metastatic serous epithelial ovarian cancer Cancer Research 2012 72:4141-4153 DOI:10.1158/0008-5472.can-11-3834 PMID:22617326 PMCID:PMC3421072
- Leikauf, G. D., Pope-Varsalona, H., Concel, V. J., Liu, P., Bein, K., Berndt, A., Martin, T. M., Ganguly, K., Jang, A. S., Brant, K. A., Dopico Jr., R. A., Upadhyay, S., et al. Integrative assessment of chlorine-induced acute lung injury in mice American Journal of Respiratory Cell and Molecular Biology 2012 47:234-244 DOI:10.1165/rcmb.2012-0026OC PMID:22447970 PMCID:PMC3423464
- Brown, M. V., McDunn, J. E., Gunst, P. R., Smith, E. M., Milburn, M. V., Troyer, D. A., Lawton, K. A. Cancer detection and biopsy classification using concurrent histopathological and metabolomic analysis of core biopsies Genome Medicine 2012 4 DOI:10.1186/gm332 PMID:22546470 PMCID:PMC3446261
- Spitzer, D., Simon, P. O., Kashiwagi, H., Xu, J., Zeng, C., Vangveravong, S., Zhou, D., Chang, K., McDunn, J. E., Hornick, J. R., Goedegebuure, P., Hotchkiss, R. S., et al. Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling Cancer Research 2012 72:201-209 DOI:10.1158/0008-5472.can-11-1354 PMID:22065721 PMCID:PMC3251632
- Parman, T., Bunin, D. I., Ng, H. H., McDunn, J. E., Wulff, J. E., Wang, A., Swezey, R., Rasay, L., Fairchild, D. G., Kapetanovic, I. M., Green, C. E. Toxicogenomics and metabolomics of pentamethylchromanol (PMCol)-induced hepatotoxicity Toxicological Sciences 2011 124:487-501 DOI:10.1093/toxsci/kfr238 PMID:21920950 PMCID:PMC3247806
- Fabisiak, J. P., Medvedovic, M., Alexander, D. C., McDunn, J. E., Concel, V. J., Bein, K., Jang, A. S., Berndt, A., Vuga, L. J., Brant, K. A., Pope-Varsalona, H., Dopico Jr., R. A., et al. Integrative metabolome and transcriptome profiling reveals discordant energetic stress between mouse strains with differential sensitivity to acrolein-induced acute lung injury Molecular Nutrition & Food Research 2011 55:1423-1434 DOI:10.1002/mnfr.201100291 PMID:21823223 PMCID:PMC3482455
- Brahmamdam, P., Inoue, S., Unsinger, J., Chang, K. C., McDunn, J. E., Hotchkiss, R. S. Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis Journal of Leukocyte Biology 2010 88:233-240 DOI:10.1189/jlb.0110037 PMID:20483923
- Spitzer, D., McDunn, J. E., Plambeck-Suess, S., Goedegebuure, P. S., Hotchkiss, R. S., Hawkins, W. G. A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing Molecular Cancer Therapeutics 2010 9:2142-2151 DOI:10.1158/1535-7163.mct-10-0225 PMID:20571073 PMCID:PMC2947203
- Feng, Y., McDunn, J. E., Teitelbaum, D. H. Decreased phospho-Akt signaling in a mouse model of total parenteral nutrition: a potential mechanism for the development of intestinal mucosal atrophy American Journal of Physiology-Gastrointestinal and Liver Physiology 2010 298:G833-G841 DOI:10.1152/ajpgi.00030.2010 PMID:20299605 PMCID:PMC3774331
- Inoue, S., Unsinger, J., Davis, C. G., Muenzer, J. T., Ferguson, T. A., Chang, K., Osborne, D. F., Clark, A. T., Coopersmith, C. M., McDunn, J. E., Hotchkiss, R. S. IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis Journal of Immunology 2010 184:1401-1409 DOI:10.4049/jimmunol.0902307 PMID:20026737 PMCID:PMC2937828
- Unsinger, J., McGlynn, M., Kasten, K. R., Hoekzema, A. S., Watanabe, E., Muenzer, J. T., McDonough, J. S., Tschoep, J., Ferguson, T. A., McDunn, J. E., Morre, M., Hildeman, D. A., et al. IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis Journal of Immunology 2010 184:3768-3779 DOI:10.4049/jimmunol.0903151 PMID:20200277 PMCID:PMC2914630
- Bradfute, S. B., Swanson, P. E., Smith, M. A., Watanabe, E., McDunn, J. E., Hotchkiss, R. S., Bavari, S. Mechanisms and consequences of ebolavirus-induced lymphocyte apoptosis Journal of Immunology 2010 184:327-335 DOI:10.4049/jimmunol.0901231 PMID:20028660
- McConnell, K. W., McDunn, J. E., Clark, A. T., Dunne, W. M., Dixon, D. J., Turnbull, I. R., DiPasco, P. J., Osberghaus, W. F., Sherman, B., Martin, J. R., Walter, M. J., Cobb, J. P., et al. Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses Critical Care Medicine 2010 38:223-241 DOI:10.1097/CCM.0b013e3181b4a76b PMID:19770740 PMCID:PMC2796712
- Hotchkiss, R. S., Strasser, A., McDunn, J. E., Swanson, P. E. Cell death New England Journal of Medicine 2009 361:1570-1583 DOI:10.1056/NEJMra0901217 PMID:19828534 PMCID:PMC3760419
- Simon, P. O., McDunn, J. E., Kashiwagi, H., Chang, K., Goedegebuure, P. S., Hotchkiss, R. S., Hawkins, W. G. Targeting AKT with the proapoptotic peptide, TAT-CTMP: A novel strategy for the treatment of human pancreatic adenocarcinoma International Journal of Cancer 2009 125:942-951 DOI:10.1002/ijc.24424 PMID:19405118 PMCID:PMC3645501
- Brahmamdam, P., Watanabe, E., Unsinger, J., Chang, K. C., Schierding, W., Hoekzema, A. S., Zhou, T. T., McDonough, J. S., Holemon, H., Heidel, J. D., Coopersmith, C. M., McDunn, J. E., et al. Targeted delivery of siRNA to cell death proteins in sepsis Shock 2009 32:131-139 DOI:10.1097/SHK.0b013e318194bcee PMID:19033888 PMCID:PMC2950011
- McDunn, J. E., Muenzer, J. T., Dunne, B., Zhou, A., Yuan, K., Hoekzema, A., Hilliard, C., Chang, K. C., Davis, C. G., McDonough, J., Hunt, C., Grigsby, P., et al. An anti-apoptotic peptide improves survival in lethal total body irradiation Biochemical and Biophysical Research Communications 2009 382:657-662 DOI:10.1016/j.bbrc.2009.03.080 PMID:19303399 PMCID:PMC2854649
- Watanabe, E., Muenzer, J. T., Hawkins, W. G., Davis, C. G., Dixon, D. J., McDunn, J. E., Brackett, D. J., Lerner, M. R., Swanson, P. E., Hotchkiss, R. S. Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study Laboratory Investigation 2009 89:549-561 DOI:10.1038/labinvest.2009.8 PMID:19188912 PMCID:PMC3822608
- Hotchkiss, R. S., Coopersmith, C. M., McDunn, J. E., Ferguson, T. A. Tilting toward immunosuppression Nature Medicine 2009 15:496-497 DOI:10.1038/nm0509-496 PMID:19424209 PMCID:PMC3786779
- Peck-Palmer, O. M., Unsinger, J., Chang, K. C., McDonough, J. S., Perlman, H., McDunn, J. E., Hotchkiss, R. S. Modulation of the Bcl-2 family blocks sepsis-induced depletion of dendritic cells and macrophages Shock 2009 31:359-366 DOI:10.1097/SHK.0b013e31818ba2a2 PMID:18838943 PMCID:PMC2778022
- Kashiwagi, H., McDunn, J. E., Simon, P. O., Goedegebuure, P. S., Vangveravong, S., Chang, K., Hotchkiss, R. S., Mach, R. H., Hawkins, W. G. Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma Journal of Translational Medicine 2009 7 DOI:10.1186/1479-5876-7-24 PMID:19323815 PMCID:PMC2669042
- McDunn, J. E., Hotchkiss, R. S. Leukocyte phenotyping to stratify septic shock patients Critical Care 2009 13 DOI:10.1186/cc7748 PMID:19439023 PMCID:PMC2689472
- Polpitiya, A. D., McDunn, J. E., Burykin, A., Ghosh, B. K., Cobb, J. P. Using systems biology to simplify complex disease: immune cartography Critical Care Medicine 2009 37:S16-S21 DOI:10.1097/CCM.0b013e3181920cb0 PMID:19104218 PMCID:PMC4077162
- Schwulst, S. J., Muenzer, J. T., Peck-Palmer, O. M., Chang, K. C., Davis, C. G., McDonough, J. S., Osborne, D. F., Walton, A. H., Unsinger, J., McDunn, J. E., Hotchkiss, R. S. Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis Shock 2008 30:127-134 DOI:10.1097/SHK.0b013e318162cf`17 PMID:18197142
- Peck-Palmer, O. M., Unsinger, J., Chang, K. C., Davis, C. G., McDunn, J. E., Hotchkiss, R. S. Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival Journal of Leukocyte Biology 2008 83:1009-1018 DOI:10.1189/jlb.0807528 PMID:18211965
- McDunn, J. E., Husain, K. D., Polpitiya, A. D., Burykin, A., Ruan, J., Li, Q., Schierding, W., Lin, N., Dixon, D., Zhang, W., Coopersmith, C. M., Dunne, W. M., et al. Plasticity of the systemic inflammatory response to acute infection during critical illness: development of the riboleukogram PLoS One 2008 3 DOI:10.1371/journal.pone.0001564 PMID:18270561 PMCID:PMC2215774
- McDunn, J. E., Muenzer, J. T., Rachdi, L., Chang, K. C., Davis, C. G., Dunne, W. M., Piwnica-Worms, D., Bernal-Mizrachi, E., Hotchkiss, R. S. Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis FASEB Journal 2008 22:561-568 DOI:10.1096/fj.07-8283com PMID:17855622 PMCID:PMC2854662
- Kashiwagi, H., McDunn, J. E., Simon, P. O., Goedegebuure, P. S., Xu, J., Jones, L., Chang, K., Johnston, F., Trinkaus, K., Hotchkiss, R. S., Mach, R. H., Hawkins, W. G. Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy Molecular Cancer 2007 6 DOI:10.1186/1476-4598-6-48 PMID:17631687 PMCID:PMC1939854
- Kashiwagi, H., McDunn, J. E., Goedegebuure, P. S., Gaffney, M. C., Chang, K., Trinkaus, K., Piwnica-Worms, D., Hotchkiss, R. S., Hawkins, W. G. TAT-Bim induces extensive apoptosis in cancer cells Annals of Surgical Oncology 2007 14:1763-1771 DOI:10.1245/s10434-006-9298-z PMID:17206479
- McConnell, K. W., Muenzer, J. T., Chang, K. C., Davis, C. G., McDunn, J. E., Coopersmith, C. M., Hilliard, C. A., Hotchkiss, R. S., Grigsby, P. W., Hunt, C. R. Anti-apoptotic peptides protect against radiation-induced cell death Biochemical and Biophysical Research Communications 2007 355:501-507 DOI:10.1016/j.bbrc.2007.01.180 PMID:17307150
- McDunn, J. E., Townsend, R. R., Cobb, J. P. The murine plasma protein response to polymicrobial intra-abdominal sepsis Proteomics Clinical Applications 2007 1:373-386 DOI:10.1002/prca.200600494 PMID:21136690
- McDunn, J. E., Turnbull, I. R., Polpitiya, A. D., Tong, A., MacMillan, S. K., Osborne, D. F., Hotchkiss, R. S., Colonna, M., Cobb, J. P. Splenic CD4+ T cells have a distinct transcriptional response six hours after the onset of sepsis Journal of the American College of Surgeons 2006 203:365-375 DOI:10.1016/j.jamcollsurg.2006.05.304 PMID:16931309
- McDunn, J. E., Chung, T. P., Laramie, J. M., Townsend, R. R., Cobb, J. P. Physiologic genomics Surgery 2006 139:133-139 DOI:10.1016/j.surg.2005.02.005 PMID:16455320
- Hotchkiss, R. S., McConnell, K. W., Bullok, K., Davis, C. G., Chang, K. C., Schwulst, S. J., Dunne, J. C., Dietz, G. P. H., Bahr, M., McDunn, J. E., Karl, I. E., Wagner, T. H., et al. TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo Journal of Immunology 2006 176:5471-5477 PMID:16622015
- Turnbull, I. R., McDunn, J. E., Takai, T., Townsend, R. R., Cobb, J. P., Colonna, M. DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis Journal of Experimental Medicine 2005 202:363-369 DOI:10.1084/jem.20050986 PMID:16061725 PMCID:PMC2213081
- McDunn, J. E., Cobb, J. P. That which does not kill you makes you stronger: a molecular mechanism for preconditioning Science STKE 2005 2005 DOI:10.1126/stke.2912005pe34 PMID:15998871
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Wentworth, P., McDunn, J. E., Wentworth, A. D., Takeuchi, C., Nieva, J., Jones, T., Bautista, C., Ruedi, J. M., Gutierrez, A., Janda, K. D., Babior, B. M., Eschenmoser, A., et al.
Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation
Science
2002
298:2195-2199
DOI:10.1126/science.1077642
PMID:12434011
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Worrall, D. S., McDunn, J. E., List, B., Reichart, D., Hevener, A., Gustafson, T., Barbas, C. F., Lerner, R. A., Olefsky, J. M.
Synthesis of an organoinsulin molecule that can be activated by antibody catalysis
Proceedings of the National Academy of Sciences of the United States of America
2001
98:13514-13518
DOI:10.1073/pnas.241516698
PMID:11707596
PMCID:PMC61072