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McDunn, Jonathan
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McDunn, Jonathan

Graduate Student
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Positions

  • 2015 - Head of Research and Development, Clinical Sensors, Inc.
  • 2012 - 2017 Adjunct Assistant Professor of Biomedical Engineering, The University of North Carolina at Chapel Hill
  • 2009 - 2015 Associate Director, Clinical Programs, Metabolon
  • 2006 - 2009 Research Assistant Professor of Anesthesiology, School of Medicine, Washington University School of Medicine , Washington University in St. Louis
  • 2003 - 2006 Postdoctoral Associate, Critical Care, Washington University School of Medicine , Washington University in St. Louis
  • 1996 - 1999 Senior Research Associate, Incyte Pharmaceuticals

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Publications

recent publications
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  • academic article

    • Tikunov, A. P., Shim, Y. S., Bhattarai, N., Siler, S. Q., Soldatow, V., LeCluyse, E. L., McDunn, J. E., Watkins, P. B., Macdonald, J. M. Dose-response in a high density three-dimensional liver device with real-time bioenergetic and metabolic flux quantification Toxicology in Vitro  2017 45:119-127  DOI:10.1016/j.tiv.2017.08.021  PMID:28867505
    • Tsalik, E. L., Willig, L. K., Rice, B. J., van Velkinburgh, J. C., Mohney, R. P., McDunn, J. E., Dinwiddie, D. L., Miller, N. A., Mayer, E. S., Glickman, S. W., Jaehne, A. K., Glew, R. H., et al. Renal systems biology of patients with systemic inflammatory response syndrome Kidney International  2015 88:804-814  DOI:10.1038/ki.2015.150  PMID:25993322  PMCID:PMC4591107
    • Wittmann, B. M., Stirdivant, S. M., Mitchell, M. W., Wulff, J. E., McDunn, J. E., Li, Z., Dennis-Barrie, A., Neri, B. P., Milburn, M. V., Lotan, Y., Wolfert, R. L. Bladder cancer biomarker discovery using global metabolomic profiling of urine PLoS One  2014 9  DOI:10.1371/journal.pone.0115870  PMID:25541698  PMCID:PMC4277370
    • Garvey, S. M., Dugle, J. E., Kennedy, A. D., McDunn, J. E., Kline, W., Guo, L., Guttridge, D. C., Pereira, S. L., Edens, N. K. Metabolomic profiling reveals severe skeletal muscle group-specific perturbations of metabolism in aged FBN rats Biogerontology  2014 15:217-232  DOI:10.1007/s10522-014-9492-5  PMID:24652515  PMCID:PMC4019835
    • Zeng, C., Vangveravong, S., McDunn, J. E., Hawkins, W. G., Mach, R. H. Sigma-2 receptor ligand as a novel method for delivering a SMAC mimetic drug for treating ovarian cancer British Journal of Cancer  2013 109:2368-2377  DOI:10.1038/bjc.2013.593  PMID:24104966  PMCID:PMC3817331
    • McDunn, J. E., Li, Z., Adam, K. P., Neri, B. P., Wolfert, R. L., Milburn, M. V., Lotan, Y., Wheeler, T. M. Metabolomic signatures of aggressive prostate cancer Prostate  2013 73:1547-1560  DOI:10.1002/pros.22704  PMID:23824564
    • Hunter, R. A., Privett, B. J., Henley, W. H., Breed, E. R., Liang, Z., Mittal, R., Yoseph, B. P., McDunn, J. E., Burd, E. M., Coopersmith, C. M., Ramsey, J. M., Schoenfisch, M. H. Microfluidic amperometric sensor for analysis of nitric oxide in whole blood Analytical Chemistry  2013 85:6066-6072  DOI:10.1021/ac400932s  PMID:23692300  PMCID:PMC3712765
    • Szabova, L., Yin, C., Bupp, S., Guerin, T. M., Schlomer, J. J., Householder, D. B., Baran, M. L., Yi, M., Song, Y., Sun, W., McDunn, J. E., Martin, P. L., et al. Perturbation of Rb, p53, and Brca1 or Brca2 cooperate in inducing metastatic serous epithelial ovarian cancer Cancer Research  2012 72:4141-4153  DOI:10.1158/0008-5472.can-11-3834  PMID:22617326  PMCID:PMC3421072
    • Leikauf, G. D., Pope-Varsalona, H., Concel, V. J., Liu, P., Bein, K., Berndt, A., Martin, T. M., Ganguly, K., Jang, A. S., Brant, K. A., Dopico Jr., R. A., Upadhyay, S., et al. Integrative assessment of chlorine-induced acute lung injury in mice American Journal of Respiratory Cell and Molecular Biology  2012 47:234-244  DOI:10.1165/rcmb.2012-0026OC  PMID:22447970  PMCID:PMC3423464
    • Brown, M. V., McDunn, J. E., Gunst, P. R., Smith, E. M., Milburn, M. V., Troyer, D. A., Lawton, K. A. Cancer detection and biopsy classification using concurrent histopathological and metabolomic analysis of core biopsies Genome Medicine  2012 4  DOI:10.1186/gm332  PMID:22546470  PMCID:PMC3446261
    • Spitzer, D., Simon, P. O., Kashiwagi, H., Xu, J., Zeng, C., Vangveravong, S., Zhou, D., Chang, K., McDunn, J. E., Hornick, J. R., Goedegebuure, P., Hotchkiss, R. S., et al. Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling Cancer Research  2012 72:201-209  DOI:10.1158/0008-5472.can-11-1354  PMID:22065721  PMCID:PMC3251632
    • Parman, T., Bunin, D. I., Ng, H. H., McDunn, J. E., Wulff, J. E., Wang, A., Swezey, R., Rasay, L., Fairchild, D. G., Kapetanovic, I. M., Green, C. E. Toxicogenomics and metabolomics of pentamethylchromanol (PMCol)-induced hepatotoxicity Toxicological Sciences  2011 124:487-501  DOI:10.1093/toxsci/kfr238  PMID:21920950  PMCID:PMC3247806
    • Fabisiak, J. P., Medvedovic, M., Alexander, D. C., McDunn, J. E., Concel, V. J., Bein, K., Jang, A. S., Berndt, A., Vuga, L. J., Brant, K. A., Pope-Varsalona, H., Dopico Jr., R. A., et al. Integrative metabolome and transcriptome profiling reveals discordant energetic stress between mouse strains with differential sensitivity to acrolein-induced acute lung injury Molecular Nutrition & Food Research  2011 55:1423-1434  DOI:10.1002/mnfr.201100291  PMID:21823223  PMCID:PMC3482455
    • Brahmamdam, P., Inoue, S., Unsinger, J., Chang, K. C., McDunn, J. E., Hotchkiss, R. S. Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis Journal of Leukocyte Biology  2010 88:233-240  DOI:10.1189/jlb.0110037  PMID:20483923
    • Spitzer, D., McDunn, J. E., Plambeck-Suess, S., Goedegebuure, P. S., Hotchkiss, R. S., Hawkins, W. G. A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing Molecular Cancer Therapeutics  2010 9:2142-2151  DOI:10.1158/1535-7163.mct-10-0225  PMID:20571073  PMCID:PMC2947203
    • Feng, Y., McDunn, J. E., Teitelbaum, D. H. Decreased phospho-Akt signaling in a mouse model of total parenteral nutrition: a potential mechanism for the development of intestinal mucosal atrophy American Journal of Physiology-Gastrointestinal and Liver Physiology  2010 298:G833-G841  DOI:10.1152/ajpgi.00030.2010  PMID:20299605  PMCID:PMC3774331
    • Inoue, S., Unsinger, J., Davis, C. G., Muenzer, J. T., Ferguson, T. A., Chang, K., Osborne, D. F., Clark, A. T., Coopersmith, C. M., McDunn, J. E., Hotchkiss, R. S. IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis Journal of Immunology  2010 184:1401-1409  DOI:10.4049/jimmunol.0902307  PMID:20026737  PMCID:PMC2937828
    • Unsinger, J., McGlynn, M., Kasten, K. R., Hoekzema, A. S., Watanabe, E., Muenzer, J. T., McDonough, J. S., Tschoep, J., Ferguson, T. A., McDunn, J. E., Morre, M., Hildeman, D. A., et al. IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis Journal of Immunology  2010 184:3768-3779  DOI:10.4049/jimmunol.0903151  PMID:20200277  PMCID:PMC2914630
    • Bradfute, S. B., Swanson, P. E., Smith, M. A., Watanabe, E., McDunn, J. E., Hotchkiss, R. S., Bavari, S. Mechanisms and consequences of ebolavirus-induced lymphocyte apoptosis Journal of Immunology  2010 184:327-335  DOI:10.4049/jimmunol.0901231  PMID:20028660
    • McConnell, K. W., McDunn, J. E., Clark, A. T., Dunne, W. M., Dixon, D. J., Turnbull, I. R., DiPasco, P. J., Osberghaus, W. F., Sherman, B., Martin, J. R., Walter, M. J., Cobb, J. P., et al. Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses Critical Care Medicine  2010 38:223-241  DOI:10.1097/CCM.0b013e3181b4a76b  PMID:19770740  PMCID:PMC2796712
    • Hotchkiss, R. S., Strasser, A., McDunn, J. E., Swanson, P. E. Cell death New England Journal of Medicine  2009 361:1570-1583  DOI:10.1056/NEJMra0901217  PMID:19828534  PMCID:PMC3760419
    • Simon, P. O., McDunn, J. E., Kashiwagi, H., Chang, K., Goedegebuure, P. S., Hotchkiss, R. S., Hawkins, W. G. Targeting AKT with the proapoptotic peptide, TAT-CTMP: A novel strategy for the treatment of human pancreatic adenocarcinoma International Journal of Cancer  2009 125:942-951  DOI:10.1002/ijc.24424  PMID:19405118  PMCID:PMC3645501
    • Brahmamdam, P., Watanabe, E., Unsinger, J., Chang, K. C., Schierding, W., Hoekzema, A. S., Zhou, T. T., McDonough, J. S., Holemon, H., Heidel, J. D., Coopersmith, C. M., McDunn, J. E., et al. Targeted delivery of siRNA to cell death proteins in sepsis Shock  2009 32:131-139  DOI:10.1097/SHK.0b013e318194bcee  PMID:19033888  PMCID:PMC2950011
    • McDunn, J. E., Muenzer, J. T., Dunne, B., Zhou, A., Yuan, K., Hoekzema, A., Hilliard, C., Chang, K. C., Davis, C. G., McDonough, J., Hunt, C., Grigsby, P., et al. An anti-apoptotic peptide improves survival in lethal total body irradiation Biochemical and Biophysical Research Communications  2009 382:657-662  DOI:10.1016/j.bbrc.2009.03.080  PMID:19303399  PMCID:PMC2854649
    • Watanabe, E., Muenzer, J. T., Hawkins, W. G., Davis, C. G., Dixon, D. J., McDunn, J. E., Brackett, D. J., Lerner, M. R., Swanson, P. E., Hotchkiss, R. S. Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study Laboratory Investigation  2009 89:549-561  DOI:10.1038/labinvest.2009.8  PMID:19188912  PMCID:PMC3822608
    • Hotchkiss, R. S., Coopersmith, C. M., McDunn, J. E., Ferguson, T. A. Tilting toward immunosuppression Nature Medicine  2009 15:496-497  DOI:10.1038/nm0509-496  PMID:19424209  PMCID:PMC3786779
    • Peck-Palmer, O. M., Unsinger, J., Chang, K. C., McDonough, J. S., Perlman, H., McDunn, J. E., Hotchkiss, R. S. Modulation of the Bcl-2 family blocks sepsis-induced depletion of dendritic cells and macrophages Shock  2009 31:359-366  DOI:10.1097/SHK.0b013e31818ba2a2  PMID:18838943  PMCID:PMC2778022
    • Kashiwagi, H., McDunn, J. E., Simon, P. O., Goedegebuure, P. S., Vangveravong, S., Chang, K., Hotchkiss, R. S., Mach, R. H., Hawkins, W. G. Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma Journal of Translational Medicine  2009 7  DOI:10.1186/1479-5876-7-24  PMID:19323815  PMCID:PMC2669042
    • McDunn, J. E., Hotchkiss, R. S. Leukocyte phenotyping to stratify septic shock patients Critical Care  2009 13  DOI:10.1186/cc7748  PMID:19439023  PMCID:PMC2689472
    • Polpitiya, A. D., McDunn, J. E., Burykin, A., Ghosh, B. K., Cobb, J. P. Using systems biology to simplify complex disease: immune cartography Critical Care Medicine  2009 37:S16-S21  DOI:10.1097/CCM.0b013e3181920cb0  PMID:19104218  PMCID:PMC4077162
    • Schwulst, S. J., Muenzer, J. T., Peck-Palmer, O. M., Chang, K. C., Davis, C. G., McDonough, J. S., Osborne, D. F., Walton, A. H., Unsinger, J., McDunn, J. E., Hotchkiss, R. S. Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis Shock  2008 30:127-134  DOI:10.1097/SHK.0b013e318162cf`17  PMID:18197142
    • Peck-Palmer, O. M., Unsinger, J., Chang, K. C., Davis, C. G., McDunn, J. E., Hotchkiss, R. S. Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival Journal of Leukocyte Biology  2008 83:1009-1018  DOI:10.1189/jlb.0807528  PMID:18211965
    • McDunn, J. E., Husain, K. D., Polpitiya, A. D., Burykin, A., Ruan, J., Li, Q., Schierding, W., Lin, N., Dixon, D., Zhang, W., Coopersmith, C. M., Dunne, W. M., et al. Plasticity of the systemic inflammatory response to acute infection during critical illness: development of the riboleukogram PLoS One  2008 3  DOI:10.1371/journal.pone.0001564  PMID:18270561  PMCID:PMC2215774
    • McDunn, J. E., Muenzer, J. T., Rachdi, L., Chang, K. C., Davis, C. G., Dunne, W. M., Piwnica-Worms, D., Bernal-Mizrachi, E., Hotchkiss, R. S. Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis FASEB Journal  2008 22:561-568  DOI:10.1096/fj.07-8283com  PMID:17855622  PMCID:PMC2854662
    • Kashiwagi, H., McDunn, J. E., Simon, P. O., Goedegebuure, P. S., Xu, J., Jones, L., Chang, K., Johnston, F., Trinkaus, K., Hotchkiss, R. S., Mach, R. H., Hawkins, W. G. Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy Molecular Cancer  2007 6  DOI:10.1186/1476-4598-6-48  PMID:17631687  PMCID:PMC1939854
    • Kashiwagi, H., McDunn, J. E., Goedegebuure, P. S., Gaffney, M. C., Chang, K., Trinkaus, K., Piwnica-Worms, D., Hotchkiss, R. S., Hawkins, W. G. TAT-Bim induces extensive apoptosis in cancer cells Annals of Surgical Oncology  2007 14:1763-1771  DOI:10.1245/s10434-006-9298-z  PMID:17206479
    • McConnell, K. W., Muenzer, J. T., Chang, K. C., Davis, C. G., McDunn, J. E., Coopersmith, C. M., Hilliard, C. A., Hotchkiss, R. S., Grigsby, P. W., Hunt, C. R. Anti-apoptotic peptides protect against radiation-induced cell death Biochemical and Biophysical Research Communications  2007 355:501-507  DOI:10.1016/j.bbrc.2007.01.180  PMID:17307150
    • McDunn, J. E., Townsend, R. R., Cobb, J. P. The murine plasma protein response to polymicrobial intra-abdominal sepsis Proteomics Clinical Applications  2007 1:373-386  DOI:10.1002/prca.200600494  PMID:21136690
    • McDunn, J. E., Turnbull, I. R., Polpitiya, A. D., Tong, A., MacMillan, S. K., Osborne, D. F., Hotchkiss, R. S., Colonna, M., Cobb, J. P. Splenic CD4+ T cells have a distinct transcriptional response six hours after the onset of sepsis Journal of the American College of Surgeons  2006 203:365-375  DOI:10.1016/j.jamcollsurg.2006.05.304  PMID:16931309
    • McDunn, J. E., Chung, T. P., Laramie, J. M., Townsend, R. R., Cobb, J. P. Physiologic genomics Surgery  2006 139:133-139  DOI:10.1016/j.surg.2005.02.005  PMID:16455320
    • Hotchkiss, R. S., McConnell, K. W., Bullok, K., Davis, C. G., Chang, K. C., Schwulst, S. J., Dunne, J. C., Dietz, G. P. H., Bahr, M., McDunn, J. E., Karl, I. E., Wagner, T. H., et al. TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo Journal of Immunology  2006 176:5471-5477  PMID:16622015
    • Turnbull, I. R., McDunn, J. E., Takai, T., Townsend, R. R., Cobb, J. P., Colonna, M. DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis Journal of Experimental Medicine  2005 202:363-369  DOI:10.1084/jem.20050986  PMID:16061725  PMCID:PMC2213081
    • McDunn, J. E., Cobb, J. P. That which does not kill you makes you stronger: a molecular mechanism for preconditioning Science STKE  2005 2005  DOI:10.1126/stke.2912005pe34  PMID:15998871
    • degree-related publication Wentworth, P., McDunn, J. E., Wentworth, A. D., Takeuchi, C., Nieva, J., Jones, T., Bautista, C., Ruedi, J. M., Gutierrez, A., Janda, K. D., Babior, B. M., Eschenmoser, A., et al. Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation Science  2002 298:2195-2199  DOI:10.1126/science.1077642  PMID:12434011
    • degree-related publication Worrall, D. S., McDunn, J. E., List, B., Reichart, D., Hevener, A., Gustafson, T., Barbas, C. F., Lerner, R. A., Olefsky, J. M. Synthesis of an organoinsulin molecule that can be activated by antibody catalysis Proceedings of the National Academy of Sciences of the United States of America  2001 98:13514-13518  DOI:10.1073/pnas.241516698  PMID:11707596  PMCID:PMC61072
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Background

education and training

  • Ph.D. in Biology, Scripps Research 1999 - 2003
  • B.S. in Chemistry, California Institute of Technology 1991 - 1995

advisee of

  • graduate advising relationship

    • Lerner, Richard, Ph.D.  candidacy, 2000 - 2003
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Contact

full name

  • Jonathan Edward McDunn

geographic location

  • Scripps California 

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