McDonald, Patricia

Faculty Member

Positions

2017 - 2018 Associate Professor, Molecular Medicine , Scripps Research
2010 - 2018 Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
2005 - 2018 Associate Scientific Director I, Translational Research Institute , Scripps Research
2010 - 2017 Assistant Professor of Molecular Therapeutics (Joint Appointment), Molecular Therapeutics , Scripps Research
2002 - 2005 Research Scientist, Eli Lilly & Company
2000 - 2002 Senior Scientist, DuPont Pharmaceuticals
1995 - 2000 Senior Postdoctoral Fellow, School of Medicine, Duke University
1993 - 1994 Postdoctoral Fellow, University of Glasgow

Dr. Patricia McDonald focuses on the development of biochemical and cell-based functional assays to identify and develop small molecule modulators of GPCRs for the treatment of metabolic and CNS disorders.

Research Areas

Drug Discovery (UMLS)

Websites

Laboratory Website

Publications
Research
Teaching
Background
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recent publications

academic article
- Levine, P. M., Balana, A. T., Sturchler, E., Koole, C., Noda, H., Zarzycka, B., Daley, E. J., Truong, T. T., Katritch, V., Gardella, T. J., Wootten, D., Sexton, P. M., et al. O-GlcNAc engineering of GPCR peptide-agonists improves their stability and in vivo activity Journal of the American Chemical Society 2019 141:14210-14219 DOI:10.1021/jacs.9b05365 PMID:31418572
- Bailey, T. L., Nieto, A., McDonald, P. H. A Nonradioactive High-Throughput Screening-Compatible Cell-Based Assay to Identify Inhibitors of the Monocarboxylate Transporter Protein 1 Assay and Drug Development Technologies 2019 17:275-284 DOI:10.1089/adt.2019.936 PMID:31532712
- Zuo, H., Glaaser, I., Zhao, Y. L., Kurinov, I., Mosyak, L., Wang, H. N., Liu, J., Park, J., Frangaj, A., Sturchler, E., Zhou, M., McDonald, P., et al. Structural basis for auxiliary subunit KCTD16 regulation of the GABA(B) receptor Proceedings of the National Academy of Sciences of the United States of America 2019 116:8370-8379 DOI:10.1073/pnas.1903024116 PMID:30971491 PMCID:PMC6486783
- Nieto, A., Fernandez-Vega, V., Spicer, T. P., Sturchler, E., Adhikari, P., Kennedy, N., Mandat, S., Chase, P., Scampavia, L., Bannister, T., Hodder, P., McDonald, P. H. Identification of Novel, Structurally Diverse, Small Molecule Modulators of GPR119 Assay and Drug Development Technologies 2018 16:278-288 DOI:10.1089/adt.2018.849 PMID:30019946 PMCID:PMC6065524
- Gutierrez, A. N., McDonald, P. H. GPCRs: Emerging anti-cancer drug targets Cellular Signalling 2017 41:65-74 DOI:10.1016/j.cellsig.2017.09.005 PMID:28931490
- Li, X., Sturchler, E., Kaczanowska, K., Cameron, M., Finn, M. G., Griffin, P., McDonald, P., Markou, A. KK-92A, a novel GABAB receptor positive allosteric modulator, attenuates nicotine self-administration and cue-induced nicotine seeking in rats. Psychopharmacology 2017 234:1633-1644 DOI:10.1007/s00213-017-4594-9 PMID:28382542
- Geng, Y., Mosyak, L., Kurinov, I., Zuo, H., Sturchler, E., Cheng, T. C., Subramanyam, P., Brown, A. P., Brennan, S. C., Mun, H. C., Bush, M., Chen, Y., et al. Structural mechanism of ligand activation in human calcium-sensing receptor Elife 2016 5 DOI:10.7554/eLife.13662 PMID:27434672 PMCID:PMC4977154
- Zhang, H., Sturchler, E., Zhu, J., Nieto, A., Cistrone, P. A., Xie, J., He, L., Yea, K., Jones, T., Turn, R., Di Stefano, P. S., Griffin, P. R., et al. Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects Nature Communications 2015 6:8918 DOI:10.1038/ncomms9918 PMID:26621478 PMCID:PMC4686834
- Robinson, J. D., McDonald, P. H. The orexin 1 receptor modulates kappa opioid receptor function via a JNK-dependent mechanism Cellular Signalling 2015 27:1449-1456 DOI:10.1016/j.cellsig.2015.03.026 PMID:25857454
- Dabul, S., Bathgate-Siryk, A., Valero, T. R., Jafferjee, M., Sturchler, E., McDonald, P., Koch, W. J., Lymperopoulos, A. Suppression of adrenal beta arrestin1-dependent aldosterone production by ARBs: head-to-head comparison Scientific Reports 2015 5:8116 DOI:10.1038/srep08116 PMID:25631300 PMCID:PMC4309955
- Di Fruscia, P., He, Y., Koenig, M., Tabrizifard, S., Nieto, A., McDonald, P. H., Kamenecka, T. M. The discovery of indole full agonists of the neurotensin receptor 1 (NTSR1) Bioorganic & Medicinal Chemistry Letters 2014 24:3974-3978 DOI:10.1016/j.bmcl.2014.06.033 PMID:24997685 PMCID:PMC4130903
- Sturchler, E., Chen, W., Spicer, T., Hodder, P., McDonald, P., Duckett, D. Development of an HTS-compatible assay for the discovery of ASK1 signalosome inhibitors using alphascreen technology Assay and Drug Development Technologies 2014 12:229-237 DOI:10.1089/adt.2013.558 PMID:24831789 PMCID:PMC4025566
- Robinson, J., Smith, A., Sturchler, E., Tabrizifard, S., Kamenecka, T., McDonald, P. Development of a high-throughput screening-compatible cell-based functional assay to identify small molecule probes of the galanin 3 receptor (GalR3) Assay and Drug Development Technologies 2013 11:468-477 DOI:10.1089/adt.2013.526 PMID:24116939 PMCID:PMC3804082
- Sturchler, E., Feurstein, D., Chen, W. M., McDonald, P., Duckett, D. Stress-induced nuclear import of apoptosis signal-regulating kinase 1 is mediated by karyopherin alpha 2/beta 1 heterodimer Biochimica et Biophysica Acta-Molecular Cell Research 2013 1833:583-592 DOI:10.1016/j.bbamcr.2012.10.023 PMID:23123190
- Begriche, K., Girardet, C., McDonald, P., Butler, A. A. Melanocortin-3 receptors and metabolic homeostasis Progress In Molecular Biology and Translational Science 2013 114:109-146 DOI:10.1016/b978-0-12-386933-3.00004-2 PMID:23317784
- Jiang, R., Song, X. Y., Bali, P., Smith, A., Bayona, C. R., Lin, L., Cameron, M. D., McDonald, P. H., Kenny, P. J., Kamenecka, T. M. Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists Bioorganic & Medicinal Chemistry Letters 2012 22:3890-3894 DOI:10.1016/j.bmcl.2012.04.122 PMID:22617492 PMCID:PMC3383661
- Begriche, K., Marston, O. J., Rossi, J., Burke, L. K., McDonald, P., Heisler, L. K., Butler, A. A. Melanocortin-3 receptors are involved in adaptation to restricted feeding Genes Brain and Behavior 2012 11:291-302 DOI:10.1111/j.1601-183X.2012.00766.x PMID:22353545 PMCID:PMC3319531
- McDonald, P., Sturchler, E. GPCRs: new opportunities and challenges for drug discovery European Pharmaceutical Review 2012 17
- Bohn, L. M., McDonald, P. H. Detecting the role of arrestins in G protein-coupled receptor regulation Neuromethods 2011 60:347-358 DOI:10.1007/978-1-61779-179-6_17
- Sturchler, E., Feurstein, D., McDonald, P., Duckett, D. Mechanism of oxidative stress-induced ASK1-catalyzed MKK6 phosphorylation Biochemistry 2010 49:4094-4102 DOI:10.1021/bi100010j PMID:20364819
- McDonald, P., Sturchler, E. Exploring GPCR desensitization using label-free technology: implications in early drug discovery International Drug Discovery 2010 6:48-54
- Bohn, L. M., McDonald, P. H. Seeking ligand bias: assessing GPCR coupling to beta-arrestins for drug discovery Drug Discovery Today. Technologies 2010 7:e37-e42 DOI:10.1016/j.ddtec.2010.06.005 PMID:21218149 PMCID:PMC3014586
- Brothers, S. P., Saldanha, S. A., Spicer, T. P., Cameron, M., Mercer, B. A., Chase, P., McDonald, P., Wahlestedt, C., Hodder, P. S. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening Molecular Pharmacology 2010 77:46-57 DOI:10.1124/mol.109.058677 PMID:19837904 PMCID:PMC2802430
- Pachori, A. S., Smith, A., McDonald, P., Zhang, L., Dzau, V. J., Melo, L. G. Heme-oxygenase-1-induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with PI3K/Akt pathway Journal of Molecular and Cellular Cardiology 2007 43:580-592 DOI:10.1016/j.yjmcc.2007.08.003 PMID:17920074 PMCID:PMC2699998
- Berglund, M. M., Schober, D. A., Statnick, M. A., McDonald, P. H., Gehlert, D. R. The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction Journal of Pharmacology and Experimental Therapeutics 2003 306:147-156 DOI:10.1124/jpet.103.051227 PMID:12665544
- Kohout, T. A., Takaoka, H., McDonald, P. H., Perry, S. J., Mao, L., Lefkowitz, R. J., Rockman, H. A. Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice Circulation 2001 104:2485-2491 DOI:10.1161/hc4501.098933 PMID:11705829
- Shenoy, S. K., McDonald, P. H., Kohout, T. A., Lefkowitz, R. J. Regulation of receptor fate by ubiquitination of activated beta(2)-adrenergic receptor and beta-arrestin Science 2001 294:1307-1313 DOI:10.1126/science.1063866 PMID:11588219
- McDonald, P. H., Lefkowitz, R. J. Beta arrestins: New roles in regulating heptahelical receptors' functions Cellular Signalling 2001 13:683-689 DOI:10.1016/s0898-6568(01)00203-0 PMID:11602178
- Miller, W. E., McDonald, P. H., Cai, S. F., Field, M. E., Davis, R. J., Lefkowitz, R. J. Identification of a motif in the carboxyl terminus of β-arrestin2 responsible for activation of JNK3 Journal of Biological Chemistry 2001 276:27770-27777 DOI:10.1074/jbc.M102264200 PMID:11356842
- McDonald, P. H., Chow, C. W., Miller, W. E., Laporte, S. A., Field, M. E., Lin, F. T., Davis, R. J., Lefkowitz, R. J. Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3 Science 2000 290:1574-1577 DOI:10.1126/science.290.5496.1574 PMID:11090355
- Alexander, M. Y., Webster, K. A., McDonald, P. H., Prentice, H. M. Gene transfer and models of gene therapy for the myocardium Clinical and Experimental Pharmacology and Physiology 1999 26:661-668 DOI:10.1046/j.1440-1681.1999.03117.x PMID:10499153
- Kypson, A. P., Hendrickson, S. C., Akhter, S. A., Wilson, K., McDonald, P. H., Lilly, R. E., Dolber, P. C., Glower, D. D., Lefkowitz, R. J., Koch, W. J. Adenovirus-mediated gene transfer of the beta(2)-adrenergic receptor to donor hearts enhances cardiac function Gene Therapy 1999 6:1298-1304 DOI:10.1038/sj.gt.3300940 PMID:10455439
- Maurice, J. P., Hata, J. A., Shah, A. S., White, D. C., McDonald, P. H., Dolber, P. C., Wilson, K. H., Lefkowitz, R. J., Glower, D. D., Koch, W. J. Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta(2)-adrenergic receptor gene delivery Journal of Clinical Investigation 1999 104:21-29 DOI:10.1172/jci6026 PMID:10393695
- McDonald, P. H., Cote, N. L., Lin, F. T., Premont, R. T., Pitcher, J. A., Lefkowitz, R. J. Identification of NSF as a beta-arrestin1-binding protein - implications for beta(2)-adrenergic receptor regulation Journal of Biological Chemistry 1999 274:10677-10680 DOI:10.1074/jbc.274.16.10677 PMID:10196135
- Akhter, S. A., Skaer, C. A., Kypson, A. P., McDonald, P. H., Peppel, K. C., Glower, D. D., Lefkowitz, R. J., Koch, W. J. Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer Proceedings of the National Academy of Sciences of the United States of America 1997 94:12100-12105 DOI:10.1073/pnas.94.22.12100 PMID:9342369 PMCID:PMC23716
- Peppel, K., Boekhoff, I., McDonald, P., Breer, H., Caron, M. G., Lefkowitz, R. J. G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization Journal of Biological Chemistry 1997 272:25425-25428 DOI:10.1074/jbc.272.41.25425 PMID:9325250
- McDonald, P., Hicks, M. N., Cobbe, S. M., Prentice, H. Gene transfer in models of myocardial ischemia Annals of the New York Academy of Sciences 1995 752:455-459 DOI:10.1111/j.1749-6632.1995.tb17455.x PMID:7755291
- Da Cruz e Silva, E. F., Hughes, V., McDonald, P., Stark, M. J. R., Cohen, P. T. W. Protein phosphatase 2Bw and protein phosphatase Z are Saccharomyces cerevisiae enzymes Biochimica et Biophysica Acta 1991 1089:269-272 DOI:10.1016/0167-4781(91)90023-F PMID:1647215
report
- Saldanha, S. A., Brothers, S. P., Spicer, T., Cameron, M., Mercer, B. A., Chase, P., McDonald, P., Wahlestedt, C., Hodder, P. S. Probe report for NPY-Y2 receptor antagonists Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:21433370

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