recent publications
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academic article
- Levine, P. M., Balana, A. T., Sturchler, E., Koole, C., Noda, H., Zarzycka, B., Daley, E. J., Truong, T. T., Katritch, V., Gardella, T. J., Wootten, D., Sexton, P. M., et al. O-GlcNAc engineering of GPCR peptide-agonists improves their stability and in vivo activity Journal of the American Chemical Society 2019 141:14210-14219 DOI:10.1021/jacs.9b05365 PMID:31418572
- Bailey, T. L., Nieto, A., McDonald, P. H. A Nonradioactive High-Throughput Screening-Compatible Cell-Based Assay to Identify Inhibitors of the Monocarboxylate Transporter Protein 1 Assay and Drug Development Technologies 2019 17:275-284 DOI:10.1089/adt.2019.936 PMID:31532712
- Zuo, H., Glaaser, I., Zhao, Y. L., Kurinov, I., Mosyak, L., Wang, H. N., Liu, J., Park, J., Frangaj, A., Sturchler, E., Zhou, M., McDonald, P., et al. Structural basis for auxiliary subunit KCTD16 regulation of the GABA(B) receptor Proceedings of the National Academy of Sciences of the United States of America 2019 116:8370-8379 DOI:10.1073/pnas.1903024116 PMID:30971491 PMCID:PMC6486783
- Nieto, A., Fernandez-Vega, V., Spicer, T. P., Sturchler, E., Adhikari, P., Kennedy, N., Mandat, S., Chase, P., Scampavia, L., Bannister, T., Hodder, P., McDonald, P. H. Identification of Novel, Structurally Diverse, Small Molecule Modulators of GPR119 Assay and Drug Development Technologies 2018 16:278-288 DOI:10.1089/adt.2018.849 PMID:30019946 PMCID:PMC6065524
- Gutierrez, A. N., McDonald, P. H. GPCRs: Emerging anti-cancer drug targets Cellular Signalling 2017 41:65-74 DOI:10.1016/j.cellsig.2017.09.005 PMID:28931490
- Li, X., Sturchler, E., Kaczanowska, K., Cameron, M., Finn, M. G., Griffin, P., McDonald, P., Markou, A. KK-92A, a novel GABAB receptor positive allosteric modulator, attenuates nicotine self-administration and cue-induced nicotine seeking in rats. Psychopharmacology 2017 234:1633-1644 DOI:10.1007/s00213-017-4594-9 PMID:28382542
- Geng, Y., Mosyak, L., Kurinov, I., Zuo, H., Sturchler, E., Cheng, T. C., Subramanyam, P., Brown, A. P., Brennan, S. C., Mun, H. C., Bush, M., Chen, Y., et al. Structural mechanism of ligand activation in human calcium-sensing receptor Elife 2016 5 DOI:10.7554/eLife.13662 PMID:27434672 PMCID:PMC4977154
- Zhang, H., Sturchler, E., Zhu, J., Nieto, A., Cistrone, P. A., Xie, J., He, L., Yea, K., Jones, T., Turn, R., Di Stefano, P. S., Griffin, P. R., et al. Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects Nature Communications 2015 6:8918 DOI:10.1038/ncomms9918 PMID:26621478 PMCID:PMC4686834
- Robinson, J. D., McDonald, P. H. The orexin 1 receptor modulates kappa opioid receptor function via a JNK-dependent mechanism Cellular Signalling 2015 27:1449-1456 DOI:10.1016/j.cellsig.2015.03.026 PMID:25857454
- Dabul, S., Bathgate-Siryk, A., Valero, T. R., Jafferjee, M., Sturchler, E., McDonald, P., Koch, W. J., Lymperopoulos, A. Suppression of adrenal beta arrestin1-dependent aldosterone production by ARBs: head-to-head comparison Scientific Reports 2015 5:8116 DOI:10.1038/srep08116 PMID:25631300 PMCID:PMC4309955
- Di Fruscia, P., He, Y., Koenig, M., Tabrizifard, S., Nieto, A., McDonald, P. H., Kamenecka, T. M. The discovery of indole full agonists of the neurotensin receptor 1 (NTSR1) Bioorganic & Medicinal Chemistry Letters 2014 24:3974-3978 DOI:10.1016/j.bmcl.2014.06.033 PMID:24997685 PMCID:PMC4130903
- Sturchler, E., Chen, W., Spicer, T., Hodder, P., McDonald, P., Duckett, D. Development of an HTS-compatible assay for the discovery of ASK1 signalosome inhibitors using alphascreen technology Assay and Drug Development Technologies 2014 12:229-237 DOI:10.1089/adt.2013.558 PMID:24831789 PMCID:PMC4025566
- Robinson, J., Smith, A., Sturchler, E., Tabrizifard, S., Kamenecka, T., McDonald, P. Development of a high-throughput screening-compatible cell-based functional assay to identify small molecule probes of the galanin 3 receptor (GalR3) Assay and Drug Development Technologies 2013 11:468-477 DOI:10.1089/adt.2013.526 PMID:24116939 PMCID:PMC3804082
- Sturchler, E., Feurstein, D., Chen, W. M., McDonald, P., Duckett, D. Stress-induced nuclear import of apoptosis signal-regulating kinase 1 is mediated by karyopherin alpha 2/beta 1 heterodimer Biochimica et Biophysica Acta-Molecular Cell Research 2013 1833:583-592 DOI:10.1016/j.bbamcr.2012.10.023 PMID:23123190
- Begriche, K., Girardet, C., McDonald, P., Butler, A. A. Melanocortin-3 receptors and metabolic homeostasis Progress In Molecular Biology and Translational Science 2013 114:109-146 DOI:10.1016/b978-0-12-386933-3.00004-2 PMID:23317784
- Jiang, R., Song, X. Y., Bali, P., Smith, A., Bayona, C. R., Lin, L., Cameron, M. D., McDonald, P. H., Kenny, P. J., Kamenecka, T. M. Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists Bioorganic & Medicinal Chemistry Letters 2012 22:3890-3894 DOI:10.1016/j.bmcl.2012.04.122 PMID:22617492 PMCID:PMC3383661
- Begriche, K., Marston, O. J., Rossi, J., Burke, L. K., McDonald, P., Heisler, L. K., Butler, A. A. Melanocortin-3 receptors are involved in adaptation to restricted feeding Genes Brain and Behavior 2012 11:291-302 DOI:10.1111/j.1601-183X.2012.00766.x PMID:22353545 PMCID:PMC3319531
- McDonald, P., Sturchler, E. GPCRs: new opportunities and challenges for drug discovery European Pharmaceutical Review 2012 17
- Bohn, L. M., McDonald, P. H. Detecting the role of arrestins in G protein-coupled receptor regulation Neuromethods 2011 60:347-358 DOI:10.1007/978-1-61779-179-6_17
- Sturchler, E., Feurstein, D., McDonald, P., Duckett, D. Mechanism of oxidative stress-induced ASK1-catalyzed MKK6 phosphorylation Biochemistry 2010 49:4094-4102 DOI:10.1021/bi100010j PMID:20364819
- McDonald, P., Sturchler, E. Exploring GPCR desensitization using label-free technology: implications in early drug discovery International Drug Discovery 2010 6:48-54
- Bohn, L. M., McDonald, P. H. Seeking ligand bias: assessing GPCR coupling to beta-arrestins for drug discovery Drug Discovery Today. Technologies 2010 7:e37-e42 DOI:10.1016/j.ddtec.2010.06.005 PMID:21218149 PMCID:PMC3014586
- Brothers, S. P., Saldanha, S. A., Spicer, T. P., Cameron, M., Mercer, B. A., Chase, P., McDonald, P., Wahlestedt, C., Hodder, P. S. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening Molecular Pharmacology 2010 77:46-57 DOI:10.1124/mol.109.058677 PMID:19837904 PMCID:PMC2802430
- Pachori, A. S., Smith, A., McDonald, P., Zhang, L., Dzau, V. J., Melo, L. G. Heme-oxygenase-1-induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with PI3K/Akt pathway Journal of Molecular and Cellular Cardiology 2007 43:580-592 DOI:10.1016/j.yjmcc.2007.08.003 PMID:17920074 PMCID:PMC2699998
- Berglund, M. M., Schober, D. A., Statnick, M. A., McDonald, P. H., Gehlert, D. R. The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction Journal of Pharmacology and Experimental Therapeutics 2003 306:147-156 DOI:10.1124/jpet.103.051227 PMID:12665544
- Kohout, T. A., Takaoka, H., McDonald, P. H., Perry, S. J., Mao, L., Lefkowitz, R. J., Rockman, H. A. Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice Circulation 2001 104:2485-2491 DOI:10.1161/hc4501.098933 PMID:11705829
- Shenoy, S. K., McDonald, P. H., Kohout, T. A., Lefkowitz, R. J. Regulation of receptor fate by ubiquitination of activated beta(2)-adrenergic receptor and beta-arrestin Science 2001 294:1307-1313 DOI:10.1126/science.1063866 PMID:11588219
- McDonald, P. H., Lefkowitz, R. J. Beta arrestins: New roles in regulating heptahelical receptors' functions Cellular Signalling 2001 13:683-689 DOI:10.1016/s0898-6568(01)00203-0 PMID:11602178
- Miller, W. E., McDonald, P. H., Cai, S. F., Field, M. E., Davis, R. J., Lefkowitz, R. J. Identification of a motif in the carboxyl terminus of β-arrestin2 responsible for activation of JNK3 Journal of Biological Chemistry 2001 276:27770-27777 DOI:10.1074/jbc.M102264200 PMID:11356842
- McDonald, P. H., Chow, C. W., Miller, W. E., Laporte, S. A., Field, M. E., Lin, F. T., Davis, R. J., Lefkowitz, R. J. Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3 Science 2000 290:1574-1577 DOI:10.1126/science.290.5496.1574 PMID:11090355
- Alexander, M. Y., Webster, K. A., McDonald, P. H., Prentice, H. M. Gene transfer and models of gene therapy for the myocardium Clinical and Experimental Pharmacology and Physiology 1999 26:661-668 DOI:10.1046/j.1440-1681.1999.03117.x PMID:10499153
- Kypson, A. P., Hendrickson, S. C., Akhter, S. A., Wilson, K., McDonald, P. H., Lilly, R. E., Dolber, P. C., Glower, D. D., Lefkowitz, R. J., Koch, W. J. Adenovirus-mediated gene transfer of the beta(2)-adrenergic receptor to donor hearts enhances cardiac function Gene Therapy 1999 6:1298-1304 DOI:10.1038/sj.gt.3300940 PMID:10455439
- Maurice, J. P., Hata, J. A., Shah, A. S., White, D. C., McDonald, P. H., Dolber, P. C., Wilson, K. H., Lefkowitz, R. J., Glower, D. D., Koch, W. J. Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta(2)-adrenergic receptor gene delivery Journal of Clinical Investigation 1999 104:21-29 DOI:10.1172/jci6026 PMID:10393695
- McDonald, P. H., Cote, N. L., Lin, F. T., Premont, R. T., Pitcher, J. A., Lefkowitz, R. J. Identification of NSF as a beta-arrestin1-binding protein - implications for beta(2)-adrenergic receptor regulation Journal of Biological Chemistry 1999 274:10677-10680 DOI:10.1074/jbc.274.16.10677 PMID:10196135
- Akhter, S. A., Skaer, C. A., Kypson, A. P., McDonald, P. H., Peppel, K. C., Glower, D. D., Lefkowitz, R. J., Koch, W. J. Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer Proceedings of the National Academy of Sciences of the United States of America 1997 94:12100-12105 DOI:10.1073/pnas.94.22.12100 PMID:9342369 PMCID:PMC23716
- Peppel, K., Boekhoff, I., McDonald, P., Breer, H., Caron, M. G., Lefkowitz, R. J. G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization Journal of Biological Chemistry 1997 272:25425-25428 DOI:10.1074/jbc.272.41.25425 PMID:9325250
- McDonald, P., Hicks, M. N., Cobbe, S. M., Prentice, H. Gene transfer in models of myocardial ischemia Annals of the New York Academy of Sciences 1995 752:455-459 DOI:10.1111/j.1749-6632.1995.tb17455.x PMID:7755291
- Da Cruz e Silva, E. F., Hughes, V., McDonald, P., Stark, M. J. R., Cohen, P. T. W. Protein phosphatase 2Bw and protein phosphatase Z are Saccharomyces cerevisiae enzymes Biochimica et Biophysica Acta 1991 1089:269-272 DOI:10.1016/0167-4781(91)90023-F PMID:1647215
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report
- Saldanha, S. A., Brothers, S. P., Spicer, T., Cameron, M., Mercer, B. A., Chase, P., McDonald, P., Wahlestedt, C., Hodder, P. S. Probe report for NPY-Y2 receptor antagonists Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:21433370