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Martin-Fardon, Remi
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Martin-Fardon, Remi

Faculty Member
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Positions

  • 2017 - Assistant Professor of Neuroscience, Neuroscience , Scripps Research
  • 2012 - 2017 Assistant Professor of Neuroscience, Molecular and Cellular Neuroscience (MCN) , Scripps Research
  • 2005 - 2012 Staff Scientist, Molecular and Integrative Neurosciences (MIND) , Scripps Research
  • 2004 Staff Scientist, Scripps Research
  • 2002 - 2004 Senior Research Associate, Scripps Research
  • 1997 - 2002 Research Associate, Scripps Research
  • 1997 Postdoctoral Fellow, Institut de Recherches Jouveinal (Parke Davis)

Research Areas research areas

  • Addiction (UMLS)

Contact

  • rmartinf@scripps.edu

Websites

  • Remi Martin-Fardon, Ph.D.
  • Laboratory Website
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Publications

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    • Matzeu, A., Martin-Fardon, R. Understanding the Role of Orexin Neuropeptides in Drug Addiction: Preclinical Studies and Translational Value Frontiers in Behavioral Neuroscience  2022 15  DOI:10.3389/fnbeh.2021.787595  PMID:35126069  PMCID:PMC8811192
    • Matzeu, A., Martin-Fardon, R. Blockade of corticotropin-releasing factor receptor 1 in the central amygdala prevents cocaine-seeking behaviour induced by orexin-A administered to the posterior paraventricular nucleus of the thalamus in male rats Journal of Psychiatry & Neuroscience  2021 46:E459-E471  DOI:10.1503/jpn.200213  PMID:34318655  PMCID:PMC8519495
    • Matzeu, A., Martin-Fardon, R. Cocaine-Seeking Behavior Induced by Orexin A Administration in the Posterior Paraventricular Nucleus of the Thalamus Is Not Long-Lasting: Neuroadaptation of the Orexin System During Cocaine Abstinence Frontiers in Behavioral Neuroscience  2021 15  DOI:10.3389/fnbeh.2021.620868  PMID:33708078  PMCID:PMC7940839
    • Pavon, F. J., Polis, I. Y., Stouffer, D. G., Cravatt, B. F., Roberto, M., Martin-Fardon, R., de Fonseca, F. R., Parsons, L. H., Serrano, A. Selective inhibition of monoacylglycerol lipase is associated with passive coping behavior and attenuation of stress-induced dopamine release in the medial prefrontal cortex Neurobiology of Stress  2021 14  DOI:10.1016/j.ynstr.2021.100293  PMID:33490317  PMCID:PMC7809503
    • Matzeu, A., Martin-Fardon, R. Blockade of Orexin Receptors in the Posterior Paraventricular Nucleus of the Thalamus Prevents Stress-Induced Reinstatement of Reward-Seeking Behavior in Rats With a History of Ethanol Dependence Frontiers in Integrative Neuroscience  2020 14  DOI:10.3389/fnint.2020.599710  PMID:33240054  PMCID:PMC7683390
    • Pavon, F. J., Polis, I., Stouffer, D. G., Roberto, M., Martin-Fardon, R., de Fonseca, F. R., Parsons, L. H., Serrano, A. COX-2 Inhibition Antagonizes Intra-Accumbens 2-Arachidonoylglycerol-Mediated Reduction in Ethanol Self-Administration in Rats Alcoholism-Clinical and Experimental Research  2020  DOI:10.1111/acer.14456  PMID:32944989
    • Suarez, J., Khom, S., Alen, F., Natividad, L. A., Varodayan, F. P., Patel, R. R., Kirson, D., Arco, R., Ballesta, A., Bajo, M., Rubio, L., Martin-Fardon, R., et al. Cessation of fluoxetine treatment increases alcohol seeking during relapse and dysregulates endocannabinoid and glutamatergic signaling in the central amygdala Addiction Biology  2020  DOI:10.1111/adb.12813  PMID:31339221
    • Matzeu, A., Martin-Fardon, R. Targeting the Orexin System for Prescription Opioid Use Disorder Brain Sciences  2020 10  DOI:10.3390/brainsci10040226  PMID:32290110  PMCID:PMC7225970
    • Matzen, A., Martin-Fardon, R. Targeting the orexin system for prescription opioid use disorder: Orexin-1 receptor blockade prevents oxycodone taking and seeking in rats Neuropharmacology  2020 164  DOI:10.1016/j.neuropharm.2019.107906  PMID:31841797  PMCID:PMC69544966
    • Kim, J. S., Martin-Fardon, R. Possible role of CRF-Hcrt interaction in the infralimbic cortex in the emergence and maintenance of compulsive alcohol-seeking behavior Alcoholism-Clinical and Experimental Research  2020  DOI:10.1111/acer.14264  PMID:31840823
    • Pavon, F. J., Serrano, A., Stouffer, D. G., Polis, I., Roberto, M., Cravatt, B. F., Martin-Fardon, R., de Fonseca, F. R., Parsons, L. H. Ethanol-induced alterations in endocannabinoids and relevant neurotransmitters in the nucleus accumbens of fatty acid amide hydrolase knockout mice Addiction Biology  2019 24:1204-1215  DOI:10.1111/adb.12695  PMID:30421483  PMCID:PMC6551299
    • Matzeu, A., Terenius, L., Martin-Fardon, R. Exploring sex differences in the attenuation of ethanol drinking by naltrexone in dependent rats during early and protracted abstinence Alcoholism-Clinical and Experimental Research  2018 42:2466-2478  DOI:10.1111/acer.13898  PMID:30320880  PMCID:PMC6286204
    • Schmeichel, B. E., Matzeu, A., Koebel, P., Vendruscolo, L. F., Sidhu, H., Shahryari, R., Kieffer, B. L., Koob, G. F., Martin-Fardon, R., Contet, C. Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats Neuropsychopharmacology  2018 43:2373-2382  DOI:10.1038/s41386-018-0054-4  PMID:29703996  PMCID:PMC6180106
    • Natividad, L. A., Steinman, M. Q., Laredo, S. A., Irimia, C., Polis, I. Y., Lintz, R., Buczynski, M. W., Martin-Fardon, R., Roberto, M., Parsons, L. H. Phosphorylation of calcium/calmodulin-dependent protein kinase II in the rat dorsal medial prefrontal cortex is associated with alcohol-induced cognitive inflexibility Addiction Biology  2018 23:1117-1129  DOI:10.1111/adb.12568  PMID:28940879  PMCID:PMC5862723
    • Gonzalez-Cuevas, G., Martin-Fardon, R., Kerr, T. M., Stouffer, D. G., Parsons, L. H., Hammell, D. C., Banks, S. L., Stinchcomb, A. L., Weiss, F. Unique treatment potential of cannabidiol for the prevention of relapse to drug use: preclinical proof of principle Neuropsychopharmacology  2018 43:2036-2045  DOI:10.1038/s41386-018-0050-8  PMID:29686308  PMCID:PMC6098033
    • Matzeu, A., Martin-Fardon, R. Drug seeking and relapse: new evidence of a role for orexin and dynorphin co-transmission in the paraventricular nucleus of the thalamus Frontiers in Neurology  2018 9  DOI:10.3389/fneur.2018.00720
    • Serrano, A., Pavon, F. J., Buczynski, M. W., Schlosburg, J., Natividad, L. A., Polis, I. Y., Stouffer, D. G., Zorrilla, E. P., Roberto, M., Cravatt, B. F., Martin-Fardon, R., de Fonseca, F. R., et al. Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake Neuropsychopharmacology  2018 43:1840-1850  DOI:10.1038/s41386-018-0055-3  PMID:29748627  PMCID:PMC6046053
    • Matzeu, A., Kallupi, M., George, O., Schweitzer, P., Martin-Fardon, R. Dynorphin counteracts orexin in the paraventricular nucleus of the thalamus: cellular and behavioral evidence Neuropsychopharmacology  2018 43:1010-1020  DOI:10.1038/npp.2017.250  PMID:29052613  PMCID:PMC5854806
    • Pavon, F. J., Serrano, A., Sidhpura, N., Polis, I., Stouffer, D., de Fonseca, F. R., Cravatt, B. F., Martin-Fardon, R., Parsons, L. H. Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens Addiction Biology  2018 23:723-734  DOI:10.1111/adb.12531  PMID:28660730  PMCID:PMC5747548
    • de Guglielmo, G., Matzeu, A., Kononoff, J., Mattioni, J., Martin-Fardon, R., George, O. Cebranopadol blocks the escalation of cocaine intake and conditioned reinstatement of cocaine seeking in rats Journal of Pharmacology and Experimental Therapeutics  2017 362:378-384  DOI:10.1124/jpet.117.241042  PMID:28645915  PMCID:PMC5539589
    • Matzeu, A., Kerr, T. M., Weiss, F., Martin-Fardon, R. Orexin-A/hypocretin-1 mediates cocaine-seeking behavior in the posterior paraventricular nucleus of the thalamus via orexin/hypocretin receptor-2 Journal of Pharmacology and Experimental Therapeutics  2016 359:273-279  DOI:10.1124/jpet.116.235945  PMID:27540003  PMCID:PMC5074483
    • Martin-Fardon, R., Cauvi, G., Kerr, T. M., Weiss, F. Differential role of hypothalamic orexin/hypocretin neurons in reward seeking motivated by cocaine versus palatable food Addiction Biology  2016 23:6-15  DOI:10.1111/adb.12441  PMID:27558790  PMCID:PMC5325827
    • Martin-Fardon, R., Weiss, F. Perseveration of craving: effects of stimuli conditioned to drugs of abuse versus conventional reinforcers differing in demand Addiction Biology  2016 22:923-932  DOI:10.1111/adb.12374  PMID:26864474  PMCID:PMC4980277
    • Matzeu, A., Weiss, F., Martin-Fardon, R. Transient inactivation of the posterior paraventricular nucleus of the thalamus blocks cocaine-seeking behavior Neuroscience Letters  2015 608:34-39  DOI:10.1016/j.neulet.2015.10.016  PMID:26455867  PMCID:PMC4639449
    • de Guglielmo, G., Martin-Fardon, R., Teshima, K., Ciccocioppo, R., Weiss, F. MT-7716, a potent NOP receptor agonist, preferentially reduces ethanol seeking and reinforcement in post-dependent rats Addiction Biology  2015 20:643-651  DOI:10.1111/adb.12157  PMID:24930632  PMCID:PMC4268094
    • Matzeu, A., Cauvi, G., Kerr, T. M., Weiss, F., Martin-Fardon, R. The paraventricular nucleus of the thalamus is differentially recruited by stimuli conditioned to the availability of cocaine versus palatable food Addiction Biology  2015 22:70-77  DOI:10.1111/adb.12280  PMID:26096647  PMCID:PMC4788574
    • Martin-Fardon, R., Weiss, F. Blockade of hypocretin receptor-1 preferentially prevents cocaine seeking: comparison with natural reward seeking Neuroreport  2014 25:485-488  DOI:10.1097/wnr.0000000000000120  PMID:24407199  PMCID:PMC3981907
    • Matzeu, A., Zamora-Martinez, E. R., Martin-Fardon, R. The paraventricular nucleus of the thalamus is recruited by both natural rewards and drugs of abuse: recent evidence of a pivotal role for orexin/hypocretin signaling in this thalamic nucleus in drug-seeking behavior Frontiers in Behavioral Neuroscience  2014 8:117  DOI:10.3389/fnbeh.2014.00117  PMID:24765071  PMCID:PMC3982054
    • Aujla, H., Cannarsa, R., Romualdi, P., Ciccocioppo, R., Martin-Fardon, R., Weiss, F. Modification of anxiety-like behaviors by nociceptin/orphanin FQ (N/OFQ) and time-dependent changes in N/OFQ-NOP gene expression following ethanol withdrawal Addiction Biology  2013 18:467-479  DOI:10.1111/j.1369-1600.2012.00466.x  PMID:22804785  PMCID:PMC3477306
    • Martin-Fardon, R., Weiss, F. Modeling relapse in animals Current topics in behavioral neurosciences  2013 13:403-32  DOI:10.1007/7854_2012_202  PMID:22389178
    • Martin-Fardon, R., Boutrel, B. Orexin/hypocretin (Orx/Hcrt) transmission and drug-seeking behavior: is the paraventricular nucleus of the thalamus (PVT) part of the drug seeking circuitry? Frontiers in Behavioral Neuroscience  2012 6:75  DOI:10.3389/fnbeh.2012.00075  PMID:23162448  PMCID:PMC3494007
    • Martin-Fardon, R., Strong, E. M., Weiss, F. Effect of sigma(1) receptor antagonism on ethanol and natural reward seeking Neuroreport  2012 23:809-813  DOI:10.1097/WNR.0b013e32835717c8  PMID:22878224
    • Martin-Fardon, R., Weiss, F. (-)-2-oxa-4-aminobicylco[3.1.0]hexane-4,6-dicarboxylic acid (LY379268) and 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine (MTEP) similarly attenuate stress-induced reinstatement of cocaine seeking Addiction Biology  2012 17:557-564  DOI:10.1111/j.1369-1600.2011.00345.x  PMID:21790902  PMCID:PMC3204322
    • Martin-Fardon, R., Weiss, F. N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl urea (SB334867), a hypocretin receptor-1 antagonist, preferentially prevents ethanol seeking: comparison with natural reward seeking Addiction Biology  2012  DOI:10.1111/j.1369-1600.2012.00480.x  PMID:22830647  PMCID:PMC3491173
    • Kufahl, P. R., Martin-Fardon, R., Weiss, F. Enhanced sensitivity to attenuation of conditioned reinstatement by the mGluR 2/3 agonist LY379268 and increased functional activity of mGluR 2/3 in rats with a history of ethanol dependence Neuropsychopharmacology  2011 36:2762-2773  DOI:10.1038/npp.2011.174  PMID:21881571  PMCID:PMC3230501
    • Economidou, D., Cippitelli, A., Stopponi, S., Braconi, S., Clementi, S., Ubaldi, M., Martin-Fardon, R., Weiss, F., Massi, M., Ciccocioppo, R. Activation of brain NOP receptors attenuates acute and protracted alcohol withdrawal symptoms in the rat Alcoholism-Clinical and Experimental Research  2011 35:747-755  DOI:10.1111/j.1530-0277.2010.01392.x  PMID:21223310  PMCID:PMC3066303
    • Hao, Y., Martin-Fardon, R., Weiss, F. Behavioral and functional evidence of metabotropic glutamate receptor 2/3 and metabotropic glutamate receptor 5 dysregulation in cocaine-escalated rats: Factor in the transition to dependence Biological Psychiatry  2010 68:240-248  DOI:10.1016/j.biopsych.2010.02.011  PMID:20416862  PMCID:PMC2907426
    • Sidhpura, N., Weiss, F., Martin-Fardon, R. Effects of the mGlu2/3 agonist LY379268 and the mGlu5 antagonist MTEP on ethanol seeking and reinforcement are differentially altered in rats with a history of ethanol dependence Biological Psychiatry  2010 67:804-811  DOI:10.1016/j.biopsych.2010.01.005  PMID:20189165  PMCID:PMC2854322
    • Braconi, S., Sidhpura, N., Aujla, H., Martin-Fardon, R., Weiss, F., Ciccocioppo, R. Revisiting intragastric ethanol intubation as a dependence induction method for studies of ethanol reward and motivation in rats Alcoholism-Clinical and Experimental Research  2010 34:538-544  DOI:10.1111/j.1530-0277.2009.01119.x  PMID:20028350  PMCID:PMC2858236
    • Martin-Fardon, R., Zorrilla, E. P., Ciccocioppo, R., Weiss, F. Role of innate and drug-induced dysregulation of brain stress and arousal systems in addiction: Focus on corticotropin-releasing factor, nociceptin/orphanin FQ, and orexin/hypocretin Brain Research  2010 1314:145-161  DOI:10.1016/j.brainres.2009.12.027  PMID:20026088  PMCID:PMC2819635
    • Martin-Fardon, R., Baptista, M. A. S., Dayas, C. V., Weiss, F. Dissociation of the effects of MTEP [3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine] on conditioned reinstatement and reinforcement: comparison between cocaine and a conventional reinforcer Journal of Pharmacology and Experimental Therapeutics  2009 329:1084-1090  DOI:10.1124/jpet.109.151357  PMID:19258516  PMCID:PMC2683783
    • Economidou, D., Hansson, A. C., Weiss, F., Terasmaa, A., Sommer, W. H., Cippitelli, A., Fedeli, A., Martin-Fardon, R., Massi, M., Ciccocioppo, R., Heilig, M. Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat Biological Psychiatry  2008 64:211-218  DOI:10.1016/j.biopsych.2008.02.004  PMID:18367152  PMCID:PMC4275225
    • Aujla, H., Martin-Fardon, R., Weiss, F. Rats with extended access to cocaine exhibit increased stress reactivity and sensitivity to the anxiolytic-like effects of the mGluR 2/3 agonist LY379268 during abstinence Neuropsychopharmacology  2008 33:1818-1826  DOI:10.1038/sj.npp.1301588  PMID:17895914
    • Martin-Fardon, R., Ciccocioppo, R., Aujla, H., Weiss, F. The dorsal subiculum mediates the acquisition of conditioned reinstatement of cocaine-seeking Neuropsychopharmacology  2008 33:1827-1834  DOI:10.1038/sj.npp.1301589  PMID:17957218
    • Dayas, C. V., McGranahan, T. M., Martin-Fardon, R., Weiss, F. Stimuli linked to ethanol availability activate hypothalamic CART and orexin neurons in a reinstatement model of relapse Biological Psychiatry  2008 63:152-157  DOI:10.1016/j.biopsych.2007.02.002  PMID:17570346
    • Gonzalez-Cuevas, G., Aujla, H., Martin-Fardon, R., Lopez-Moreno, J. A., Navarro, M., Weiss, F. Subchronic cannabinoid agonist (WIN 55,212-2) treatment during cocaine abstinence alters subsequent cocaine seeking behavior Neuropsychopharmacology  2007 32:2260-2266  DOI:10.1038/sj.npp.1301365  PMID:17392740
    • Martin-Fardon, R., Maurice, T., Aujla, H., Bowen, W. D., Weiss, F. Differential effects of sigma(1) receptor blockade on self-administration and conditioned reinstatement motivated by cocaine vs natural reward Neuropsychopharmacology  2007 32:1967-1973  DOI:10.1038/sj.npp.1301323  PMID:17268407
    • Economidou, D., Fedeli, A., Fardon, R. M., Weiss, F., Massi, M., Ciccocioppo, R. Effect of novel nociceptin/orphanin FQ-NOP receptor ligands on ethanol drinking in alcohol-preferring msP rats Peptides  2006 27:3299-3306  DOI:10.1016/j.peptides.2006.09.007  PMID:17097763  PMCID:PMC1847604
    • Zhao, Y., Dayas, C. V., Aujla, H., Baptista, M. A. S., Martin-Fardon, R., Weiss, F. Activation of group II metabotropic glutamate receptors attenuates both stress and cue-induced ethanol-seeking and modulates c-fos expression in the hippocampus and amygdala Journal of Neuroscience  2006 26:9967-9974  DOI:10.1523/jneurosci.2384-06.2006  PMID:17005860
    • Boutrel, B., Kenny, P. J., Specio, S. E., Martin-Fardon, R., Markou, A., Koob, G. F., de Lecea, L. Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior Proceedings of the National Academy of Sciences of the United States of America  2005 102:19168-19173  DOI:10.1073/pnas.0507480102  PMID:16357203  PMCID:PMC1323172
    • Martin-Fardon, R., Lorentz, C. U., Stuempfig, N. D., Weiss, F. Priming with BTCP, a dopamine reuptake blocker, reinstates cocaine-seeking and enhances cocaine cue-induced reinstatement Pharmacology, Biochemistry and Behavior  2005 82:46-54  DOI:10.1016/j.pbb.2005.07.010  PMID:16099021
    • Romieu, P., Meunier, J., Garcia, D., Zozime, N., Martin-Fardon, R., Bowen, W. D., Maurice, T. The sigma(1) (sigma(1)) receptor activation is a key step for the reactivation of cocaine conditioned place preference by drug priming Psychopharmacology  2004 175:154-162  DOI:10.1007/s00213-004-1814-x  PMID:14985920
    • Baptista, M. A. S., Martin-Fardon, R., Weiss, F. Preferential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement: comparison between cocaine and a potent conventional reinforcer Journal of Neuroscience  2004 24:4723-4727  DOI:10.1523/jneurosci.0176-04.2004  PMID:15152032
    • Dayas, C. V., Martin-Fardon, R., Thorsell, A., Weiss, F. Chronic footshock, but not a physiological stressor, suppresses the alcohol deprivation effect in dependent rats Alcohol and Alcoholism  2004 39:190-196  DOI:10.1093/alcalc/agh046  PMID:15082455
    • Ciccocioppo, R., Martin-Fardon, R., Weiss, F. Stimuli associated with a single cocaine experience elicit longlasting cocaine-seeking Nature Neuroscience  2004 7:495-496  DOI:10.1038/nn1219  PMID:15048121
    • Martin-Fardon, R., Lorentz, C. U., Kamenka, J. M., Weiss, F. 3-OH-pip-BTCP, a metabolite of the potent DA uptake blocker BTCP, exerts cocaine-like action in rats Neuroreport  2003 14:2439-2444  DOI:10.1097/01.wnr.0000099608.19426.39  PMID:14663207
    • Ciccocioppo, R., Lin, D., Martin-Fardon, R., Weiss, F. Reinstatement of ethanol-seeking behavior by drug cues following single versus multiple ethanol intoxication in the rat: Effects of naltrexone Psychopharmacology  2003 168:208-215  DOI:10.1007/s00213-002-1380-z  PMID:12664190
    • Romieu, P., Martin-Fardon, R., Bowen, W. D., Maurice, T. Sigma(1) receptor-related neuroactive steroids modulate cocaine-induced reward Journal of Neuroscience  2003 23:3572-3576  PMID:12736327
    • Izzo, E., Martin-Fardon, R., Koob, G. F., Weiss, F., Sanna, P. P. Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization Nature Neuroscience  2002 5:1263-1264  DOI:10.1038/nn977  PMID:12436114
    • Ciccocioppo, R., Martin-Fardon, R., Weiss, F. Effect of selective blockade of mu(1) or delta opioid receptors on reinstatement of alcohol-seeking behavior by drug-associated stimuli in rats Neuropsychopharmacology  2002 27:391-399  DOI:10.1016/s0893-133x(02)00302-0  PMID:12225696
    • Maurice, T., Martin-Fardon, R., Romieu, P., Matsumoto, R. R. Sigma(1) (sigma(1)) receptor antagonists represent a new strategy against cocaine addiction and toxicity Neuroscience and Biobehavioral Reviews  2002 26:499-527  DOI:10.1016/S0149-7634(02)00017-9  PMID:12204195
    • Martin-Fardon, R., Weiss, F. BTCP is a potent reinforcer in rats: comparison of behavior maintained on fixed- and progressive-ratio schedules Pharmacology, Biochemistry and Behavior  2002 72:343-353  DOI:10.1016/s0091-3057(01)00764-x  PMID:11900805
    • Romieu, P., Phan, V. L., Martin-Fardon, R., Maurice, T. Involvement of the sigma(1) receptor in cocaine-induced conditioned place preference: Possible dependence on dopamine uptake blockade Neuropsychopharmacology  2002 26:444-455  DOI:10.1016/s0893-133x(01)00391-8  PMID:11927169
    • Martin-Fardon, R., Kerr, T. M., Deleuze-Masquefa, C., Kamenka, J. M., Weiss, F. Behavioral and neurochemical effects of 3-OH-pip-BTCP, an active metabolite of BTCP in rats Neuroreport  2001 12:4165-4169  DOI:10.1097/00001756-200112210-00060  PMID:11742258
    • Weiss, F., Martin-Fardon, R., Ciccocioppo, R., Kerr, T. M., Smith, D. L., Ben-Shahar, O. Enduring resistance to extinction of cocaine-seeking behavior induced by drug-related cues Neuropsychopharmacology  2001 25:361-372  DOI:10.1016/s0893-133x(01)00238-x  PMID:11522464
    • Ciccocioppo, R., Martin-Fardon, R., Weiss, F., Massi, M. Nociceptin/orphanin FQ inhibits stress- and CRF-induced anorexia in rats Neuroreport  2001 12:1145-1149  DOI:10.1097/00001756-200105080-00019  PMID:11338181
    • Romieu, P., Martin-Fardon, R., Maurice, T. Involvement of the sigma(1) receptor in the cocaine-induced conditioned place preference Neuroreport  2000 11:2885-2888  DOI:10.1097/00001756-200009110-00011  PMID:11006959
    • Martin-Fardon, R., Weiss, F. N-[1-(2-benzo[b]thiophenyl)Cyclohexyl]- piperidine (BTCP) exerts cocaine-like actions on drug-maintained responding in rats Neuropsychopharmacology  2000 23:316-325  DOI:10.1016/s0893-133x(00)00104-4  PMID:10942855
    • Martin-Fardon, R., Ben-Shahar, O., Weiss, F. Non reciprocal cross-sensitization between cocaine and BTCP on locomotor activity in the rat Pharmacology, Biochemistry and Behavior  2000 66:631-635  DOI:10.1016/s0091-3057(00)00262-8  PMID:10899381
    • Martin-Fardon, R., Ciccocioppo, R., Massi, M., Weiss, F. Nociceptin prevents stress-induced ethanol- but not cocaine-seeking behavior in rats Neuroreport  2000 11:1939-1943  DOI:10.1097/00001756-200006260-00026  PMID:10884047
    • Martin-Fardon, R., Sandillon, F., Thibault, J., Privat, A., Vignon, J. Long-term monitoring of extracellular dopamine concentration in the rat striatum by a repeated microdialysis procedure Journal of Neuroscience Methods  1997 72:123-135  DOI:10.1016/s0165-0270(96)02170-x  PMID:9133576
    • Martin-Fardon, R., Arnaud, M., Rousseau, E., Kamenka, J. M., Privat, A., Vignon, J. N-[1-(2-Benzo(b)thiophenyl)cyclohexyl]piperidine (BTCP) and cocaine induce similar effects on striatal dopamine: a microdialysis study in freely moving rats Neuroscience Letters  1996 211:179-182  DOI:10.1016/0304-3940(96)12744-0  PMID:8817570
    • Coderc, E., Martin-Fardon, R., Vignon, J., Kamenka, J. M. New compounds resulting from structural and biochemical similarities between GBR 1278 and BTCP, two potent inhibitors of dopamine uptake European Journal of Medicinal Chemistry  1993 28:893-898  DOI:10.1016/0223-5234(93)90042-d

featured in

  • Persistent Memories of Cocaine  Newsletter
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Research

research overview

  • A major challenge for the successful treatment of drug addiction is the long-lasting susceptibility to relapse during abstinence. The goal of our studies is to advance the understanding of the implication of the orexin (Orx/Hcrt) system in cocaine and alcohol seeking. In addition to the Orx/Hcrt system, which includes the lateral hypothalamus (LH), dorsomedial hypothalamus (DMH), and perifornical area (PFA), the paraventricular nucleus of the thalamus (PVT), which receives projections from the LH and projects to regions integrated in the circuitry of addiction (i.e., nucleus accumbens shell, ventral pallidum, ventral tegmental area, central nucleus of the amygdala, and bed nucleus of the stria terminalis), has been recently identified as a structure involved in the modulation of reward function in general and drug-directed behavior in particular. Importantly, we recently characterized a correlation between cocaine-seeking behavior and activation of the PVT, but not in the case of natural reward (food)-seeking behavior. This suggests that cocaine dysregulates neurotransmission within the PVT. Capitalizing on these findings, our working hypothesis is that following repeated drug use, the Orx/Hcrt system acquires a preferential role in mediating the seeking of drugs of abuse vs. natural rewards (such as food). Therefore, the main effort of my laboratory is to study the neurobiological basis of chronic vulnerability to relapse by focusing on Orx/Hcrt transmission in the PVT as a novel neural substrate that may be responsible for the distinctly compulsive nature of drug (cocaine or alcohol) seeking as opposed to behavior motivated by natural rewards. Specifically, we are (i) behaviorally characterizing the specific implication of the PVT in drug seeking, (ii) investigating drug-induced neuroplastic changes within Orx/Hcrt transmission, and (iii) investigating the effects of dysregulated Orx/Hcrt-PVT transmission on the mesolimbic system. Overall, this work will provide novel insights into the specific involvement of Orx/Hcrt-PVT transmission in drug-seeking behavior compared with natural reward-seeking behavior and will likely highlight a previously unrecognized neurotransmission system in the etiology of compulsive drug seeking during abstinence.
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Background

education and training

  • Ph.D. in Biochemistry and Molecular Biology, University of Montpellier 2 1996
  • M.S. in Physiology and Pharmacology, University of Montpellier 2 1990
  • B.S. in Cellular Biology and Physiology, University of Montpellier 2 1989
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Contact

full name

  • Remi Martin-Fardon

geographic location

  • Scripps California 

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