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Lewis, Bryan
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Lewis, Bryan

Graduate Student
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Positions

  • 2015 - 2017 Vice President of Pharmaceutical Sciences, Axovant Sciences
  • 2015 Executive Director, CMC Alliance and Partnership, Eisai

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  • Doctoral Dissertation
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Publications

recent publications
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  • academic article

    • Austad, B. C., Calkins, T. L., Chase, C. E., Fang, F. G., Horstmann, T. E., Hu, Y., Lewis, B. M., Niu, X., Noland, T. A., Orr, J. D., Schnaderbeck, M. J., Zhang, H., et al. Commercial manufacture of Halaven: chemoselective transformations en route to structurally complex macrocyclic ketones Synlett  2013 24:333-337  DOI:10.1055/s-0032-1318026
    • Chase, C. E., Fang, F. G., Lewis, B. M., Wilkie, G. D., Schnaderbeck, M. J., Zhu, X. Process development of Halaven: synthesis of the C1-C13 fragment from D-(-)-gulono-1,4-lactone Synlett  2013 24:323-326  DOI:10.1055/s-0032-1317919
    • Austad, B. C., Benayoud, F., Calkins, T. L., Campagna, S., Chase, C. E., Choi, H. W., Christ, W., Costanzo, R., Cutter, J., Endo, A., Fang, F. G., Hu, Y., et al. Process development of Halaven: synthesis of the C14-C35 fragment via iterative Nozaki-Hiyama-Kishi reaction-Williamson ether cyclization Synlett  2013 24:327-332  DOI:10.1055/s-0032-1317920
    • Narayan, S., Carlson, E. M., Cheng, H., Du, H., Hu, Y., Jiang, Y., Lewis, B. M., Seletsky, B. M., Tendyke, K., Zhang, H., Zheng, W., Littlefield, B. A., et al. Novel second generation analogs of eribulin. Part I: Compounds containing a lipophilic C32 side chain overcome P-glycoprotein susceptibility Bioorganic & Medicinal Chemistry Letters  2011 21:1630-1633  DOI:10.1016/j.bmcl.2011.01.111  PMID:21324686
    • Narayan, S., Carlson, E. M., Cheng, H., Condon, K., Du, H., Eckley, S., Hu, Y., Jiang, Y., Kumar, V., Lewis, B. M., Saxton, P., Schuck, E., et al. Novel second generation analogs of eribulin. Part II: Orally available and active against resistant tumors in vivo Bioorganic & Medicinal Chemistry Letters  2011 21:1634-1638  DOI:10.1016/j.bmcl.2011.01.097  PMID:21324692
    • Narayan, S., Carlson, E. M., Cheng, H., Condon, K., Du, H., Eckley, S., Hu, Y., Jiang, Y., Kumar, V., Lewis, B. M., Saxton, P., Schuck, E., et al. Novel second generation analogs of eribulin. Part III: Blood-brain barrier permeability and in vivo activity in a brain tumor model Bioorganic & Medicinal Chemistry Letters  2011 21:1639-1643  DOI:10.1016/j.bmcl.2011.01.096  PMID:21324687
    • Towle, M. J., Salvato, K. A., Wels, B. F., Aalfs, K. K., Zheng, W., Seletsky, B. M., Zhu, X., Lewis, B. M., Kishi, Y., Yu, M. J., Littlefield, B. A. Eribulin induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions Cancer Research  2011 71:496-505  DOI:10.1158/0008-5472.can-10-1874  PMID:21127197
    • Smith, J. A., Wilson, L., Azarenko, O., Zhu, X., Lewis, B. M., Littlefield, B. A., Jordan, M. A. Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instability Biochemistry  2010 49:1331-1337  DOI:10.1021/bi901810u  PMID:20030375  PMCID:PMC2846717
    • degree-related publication Boger, D. L., Hikota, M., Lewis, B. M. Determination of the relative and absolute stereochemistry of fostriecin (CL-920) Journal of Organic Chemistry  1997 62:1748-1753  DOI:10.1021/jo962166h
    • Chen, B. C., Murphy, C. K., Kumar, A., Reddy, R. T., Clark, C., Zhou, P., Lewis, B. M., Gala, D., Mergelsberg, I., Scherer, D., Buckley, J., DiBenedetto, D., et al. (+)-(2R,8aR*)- (8,8-dimethoxycamphoryl)sulfonyl oxaziridine and (+)-(2R,8aR*)- (8,8-dichlorocamphoryl)sulfonyl oxaziridine - ( 4H-4a,7-methanooxazirino 3,2-i 2,1 benzisothiazole, tetrahydro-8,8-dimethoxy-9,9-dimethyl-, 3,3-dioxide , 2R-(2 alpha,4a alpha,7 alpha,8aR*) - and 4H-4a,7-methanooxazirino 3,2-i 2,1 benzisothiazole, 8,8-dichlorotetrahydro-9,9-dimethyl-, 3,3-dioxide, 2R-(2 alpha,4a alpha,7 alpha,8aR*) ) Organic Syntheses  1996 73:159-173  DOI:10.15227/orgsyn.073.0159
    • Gilligan, P. J., Kergaye, A. A., Lewis, B. M., McElroy, J. F. Piperidinyltetralin sigma ligands Journal of Medicinal Chemistry  1994 37:364-370  DOI:10.1021/jm00029a008  PMID:7905926
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Background

education and training

  • Ph.D. in Chemistry, Scripps Research 1993 - 1999
  • B.S. in Chemistry, Drexel University 1988 - 1993

advisee of

  • graduate advising relationship

    • Boger, Dale, Ph.D.  candidacy, 1994 - 1999
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Contact

full name

  • Bryan Matthew Lewis

geographic location

  • Scripps California 

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