recent publications
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academic article
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Ogasawara, D., Ichu, T. A., Jing, H., Hulce, J. J., Reed, A., Ulanovskaya, O. A., Cravatt, B. F.
Discovery and optimization of selective and in vivo active inhibitors of the lysophosphatidylserine lipase α/β-hydrolase domain-containing 12 (ABHD12)
Journal of Medicinal Chemistry
2019
62:1643-1656
DOI:10.1021/acs.jmedchem.8b01958
PMID:30720278
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Bi, J., Ichu, T. A., Zanca, C., Yang, H., Zhang, W., Gu, Y., Chowdhry, S., Reed, A., Ikegami, S., Turner, K. M., Zhang, W., Villa, G. R., et al.
Oncogene amplification in growth factor signaling pathways renders cancers dependent on membrane lipid remodeling
Cell Metabolism
2019
30:525-538
DOI:10.1016/j.cmet.2019.06.014
PMID:31303424
PMCID:PMC6742496
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Ogasawara, D., Ichu, T. A., Vartabedian, V. F., Benthuysen, J., Jing, H., Reed, A., Ulanovskaya, O. A., Hulce, J. J., Roberts, A., Brown, S., Rosen, H., Teijaro, J. R., et al.
Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo
Nature Chemical Biology
2018
14:1099-1108
DOI:10.1038/s41589-018-0155-8
PMID:30420694
PMCID:PMC6263940
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Bar-Peled, L.*, Kemper, E. K.*, Suciu, R. M., Vinogradova, E. V., Backus, K. M., Horning, B. D., Paul, T. A., Ichu, T. A., Svensson, R. U., Olucha, J., Chang, M. W., Kok, B. P., et al.
Chemical proteomics identifies druggable vulnerabilities in a genetically defined cancer
Cell
2017
171:696-709
DOI:10.1016/j.cell.2017.08.051
PMID:28965760
(* = equal contribution)
- Maher, S. K., Wojnarowicz, P., Ichu, T. A., Veldhoen, N., Lu, L., Lesperance, M., Propper, C. R., Helbing, C. C. Rethinking the biological relationships of the thyroid hormones, L-thyroxine and 3,5,3 '-triiodothyronine Comparative Biochemistry and Physiology D-Genomics & Proteomics 2016 18:44-53 DOI:10.1016/j.cbd.2016.04.002 PMID:27085304
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Niphakis, M. J., Lum, K. M., Cognetta III, A. B., Correia, B. E., Ichu, T. A., Olucha, J., Brown, S. J., Kundu, S., Piscitelli, F., Rosen, H., Cravatt, B. F.
A global map of lipid-binding proteins and their ligandability in cells
Cell
2015
161:1668-1680
DOI:10.1016/j.cell.2015.05.045
PMID:26091042
PMCID:PMC4615699
- Ichu, T. A., Han, J., Borchers, C. H., Lesperance, M., Helbing, C. C. Metabolomic insights into system-wide coordination of vertebrate metamorphosis BMC Developmental Biology 2014 14 DOI:10.1186/1471-213x-14-5 PMID:24495308 PMCID:PMC3928663
- Cheng, S. W. G., Kuzyk, M. A., Moradian, A., Ichu, T. A., Chang, V. C. D., Tien, J. F., Vollett, S. E., Griffith, M., Marra, M. A., Morin, G. B. Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II Molecular and Cellular Biology 2012 32:4691-4704 DOI:10.1128/mcb.06267-11 PMID:22988298 PMCID:PMC3486194
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