recent publications
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academic article
- Deguchi, H., Shukla, M., Hayat, M., Torkamani, A., Elias, D. J., Griffin, J. H. Novel exomic rare variants associated with venous thrombosis British Journal of Haematology 2020 DOI:10.1111/bjh.16613 PMID:32232851
- von Drygalski, A., Bhat, V., Gale, A. J., Averell, P. M., Cramer, T. J., Elias, D. J., Griffin, J. H., Mosnier, L. O. An engineered factor Va prevents bleeding induced by direct-acting oral anticoagulants by different mechanisms Blood Advances 2020 4:3716-3727 DOI:10.1182/bloodadvances.2020001699 PMID:32777068 PMCID:PMC7422119
- Heeb, M. J., Fernandez, J. A., Yamashita, A., McDowell, O. R., Guo, Z. H., Mosnier, L. O., Deguchi, H., Griffin, J. H. Activated protein C anticoagulant activity is enhanced by skeletal muscle myosin Haematologica 2020 105:E424-E427 DOI:10.3324/haematol.2019.242982 PMID:31857364 PMCID:PMC7395292
- Mukherjee, P., Lyden, P., Fernandez, J. A., Davis, T. P., Pryor, K. E., Zlokovic, B. V., Griffin, J. H. 3K3A-Activated Protein C Variant Does Not Interfere With the Plasma Clot Lysis Activity of Tenecteplase Stroke 2020 51:2236-2239 DOI:10.1161/strokeaha.120.028793 PMID:32568648 PMCID:PMC7380733
- Yamashita, A., Zhang, Y. Q., Sanner, M. F., Griffin, J. H., Mosnier, L. O. C-terminal residues of activated protein C light chain contribute to its anticoagulant and cytoprotective activities Journal of Thrombosis and Haemostasis 2020 18:1027-1038 DOI:10.1111/jth.14756 PMID:32017367
- Kondreddy, V., Pendurthi, U. R., Xu, X., Griffin, J. H., Rao, L. V. M. FVIIa (Factor VIIa) Induces Biased Cytoprotective Signaling in Mice Through the Cleavage of PAR (Protease-Activated Receptor)-1 at Canonical Arg41 (Arginine41) Site Arteriosclerosis Thrombosis and Vascular Biology 2020 40:1275-1288 DOI:10.1161/atvbaha.120.314244 PMID:32212848
- Deguchi, T. K., Deguchi, H., Guo, Z., Elias, D. J., Griffin, J. H. Plasma skeletal muscle myosin phenotypes identified by immunoblotting are associated with pulmonary embolism occurrence in young adults Thrombosis Research 2020 189:88-92 DOI:10.1016/j.thromres.2020.02.020 PMID:32192996
- Kant, R., Halder, S. K., Fernandez, J. A., Griffin, J. H., Milner, R. Activated Protein C Attenuates Experimental Autoimmune Encephalomyelitis Progression by Enhancing Vascular Integrity and Suppressing Microglial Activation Frontiers in Neuroscience 2020 14 DOI:10.3389/fnins.2020.00333 PMID:32351356 PMCID:PMC7174764
- Zilberman-Rudenko, J., Deguchi, H., Shukla, M., Oyama, Y., Orje, J. N., Guo, Z. H., Wyseure, T., Mosnier, L. O., McCarty, O. J. T., Ruggeri, Z. M., Eckle, T., Griffin, J. H. Cardiac Myosin Promotes Thrombin Generation and Coagulation In Vitro and In Vivo Arteriosclerosis Thrombosis and Vascular Biology 2020 40:901-913 DOI:10.1161/atvbaha.120.313990 PMID:32102568 PMCID:PMC7135739
- Deguchi, H., Morla, S., Griffin, J. H. Novel blood coagulation molecules: Skeletal muscle myosin and cardiac myosin Journal of Thrombosis and Haemostasis 2020 DOI:10.1111/jth.15097 PMID:32920971 PMCID:PMC7819347
- Coleman, J. R., Moore, E. E., Zilberman-Rudenko, J., Samuels, J. M., Cohen, M. J., Silliman, C. C., Banerjee, A., Sauaia, A., Griffin, J. H., Deguchi, H. Cardiac and skeletal muscle myosin exert procoagulant effects Shock 2019 52:554-555 DOI:10.1097/shk.0000000000001426 PMID:31613865
- Deguchi, H., Guo, Z., Hayat, M., Pflimlin, E., Lear, S., Shen, W., Griffin, J. H. Molecular interaction site on procoagulant myosin for factor Xa?dependent prothrombin activation Journal of Biological Chemistry 2019 294:15176-15181 DOI:10.1074/jbc.AC119.010236 PMID:31481465 PMCID:PMC6791324
- Muller-Calleja, N., Hollerbach, A., Ritter, S., Pedrosa, D. G., Strand, D., Graf, C., Reinhardt, C., Strand, S., Poncelet, P., Griffin, J. H., Lackner, K. J., Ruf, W. Tissue factor pathway inhibitor primes monocytes for antiphospholipid antibody-induced thrombosis Blood 2019 134:1119-1131 DOI:10.1182/blood.2019001530 PMID:31434703
- Sinha, R. K., Flynn, R., Zaiken, M., Paz, K., Gavin, A. L., Nemazee, D., Fernandez, J. A., Xu, X., Griffin, J. H., Blazar, B. R. Activated protein C ameliorates chronic graft-versus-host disease by PAR1-dependent biased cell signaling on T cells Blood 2019 134:776-781 DOI:10.1182/blood.2019001259 PMID:31243040 PMCID:PMC6716074
- Rajput, P. S., Lamb, J. A., Fernandez, J. A., Bai, J., Pereira, B. R., Lei, I. F., Leung, J., Griffin, J. H., Lyden, P. D. Neuroprotection and vasculoprotection using genetically targeted protease-ligands Brain Research 2019 1715:13-20 DOI:10.1016/j.brainres.2019.03.010 PMID:30880117 PMCID:PMC6500472
- Lazic, D., Sagare, A. P., Nikolakopoulou, A. M., Griffin, J. H., Vassar, R., Zlokovic, B. V. 3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice Journal of Experimental Medicine 2019 216:279-293 DOI:10.1084/jem.20181035 PMID:30647119 PMCID:PMC6363429
- Lyden, P., Pryor, K. E., Coffey, C. S., Cudkowicz, M., Conwit, R., Jadhav, A., Sawyer, R. N., Claassen, J., Adeoye, O., Song, S., Hannon, P., Rost, N. S., et al. Final Results of the RHAPSODY Trial: A Multi-center, phase 2 trial using a continual reassessment method to determine the safety and tolerability of 3K3A-APC, a recombinant variant of human activated protein C, in combination with tissue plasminogen activator, mechanical thrombectomy or both in moderate to severe acute ischemic stroke Annals of Neurology 2019 85:125-136 DOI:10.1002/ana.25383 PMID:30450637 PMCID:PMC6342508
- Mukherjee, P., Leman, L. J., Griffin, J. H., Ghadiri, M. R. Design of a DNA-programmed plasminogen activator Journal of the American Chemical Society 2018 140:15516-15524 DOI:10.1021/jacs.8b10166 PMID:30347143
- Griffin, J. H., Zlokovic, B. V., Mosnier, L. O. Activated protein C, protease activated receptor 1, and neuroprotection Blood 2018 132:159-169 DOI:10.1182/blood-2018-02-769026 PMID:29866816 PMCID:PMC6043978
- Healy, L. D., Rigg, R. A., Griffin, J. H., McCarty, O. J. T. Regulation of immune cell signaling by activated protein C Journal of Leukocyte Biology 2018 103:1197-1203 DOI:10.1002/jlb.3mir0817-338r PMID:29601101
- Gupta, N., Liu, R., Shin, S., Sinha, R., Pogliano, J., Pogliano, K., Griffin, J. H., Nizet, V., Corriden, R. SCH79797 improves outcomes in experimental bacterial pneumonia by boosting neutrophil killing and direct antibiotic activity Journal of Antimicrobial Chemotherapy 2018 73:1586-1594 DOI:10.1093/jac/dky033 PMID:29514266 PMCID:PMC5961356
- Amar, A. P., Sagare, A. P., Zhao, Z., Wang, Y., Nelson, A. R., Griffin, J. H., Zlokovic, B. V. Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C Neuropharmacology 2018 134:293-301 DOI:10.1016/j.neuropharm.2017.09.021 PMID:28923278 PMCID:PMC5857404
- Gupta, N., Sinha, R., Krasnodembskaya, A., Xu, X., Nizet, V., Matthay, M. A., Griffin, J. H. The TLR4-PAR1 axis regulates bone marrow mesenchymal stromal cell survival and therapeutic capacity in experimental bacterial pneumonia Stem Cells 2018 36:796-806 DOI:10.1002/stem.2796 PMID:29396891 PMCID:PMC5918231
- Martos, L., Ramon, L. A., Oto, J., Fernandez-Pardo, A., Bonanad, S., Cid, A. R., Gruber, A., Griffin, J. H., Espana, F., Navarro, S., Medina, P. α2-macroglobulin is a significant in vivo inhibitor of activated protein C and low APC:α2M levels are associated with venous thromboembolism Thrombosis and Haemostasis 2018 118:630-638 DOI:10.1055/s-0038-1629902 PMID:29448296
- Prince, R., Bologna, L., Manetti, M., Melchiorre, D., Rosa, I., Dewarrat, N., Suardi, S., Amini, P., Fernandez, J. A., Burnier, L., Quarroz, C., Caro, M. D. R., et al. Targeting anticoagulant protein S to improve hemostasis in hemophilia Blood 2018 131:1360-1371 DOI:10.1182/blood-2017-09-800326 PMID:29317453 PMCID:PMC5865230
- Sinha, R. K., Wang, Y., Zhao, Z., Xu, X., Burnier, L., Gupta, N., Fernandez, J. A., Martin, G., Kupriyanov, S., Mosnier, L. O., Zlokovic, B. V., Griffin, J. H. PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke Blood 2018 131:1163-1171 DOI:10.1182/blood-2017-10-810895 PMID:29343482 PMCID:PMC5855020
- Nazir, S., Gadi, I., Al-Dabet, M. M., Elwakiel, A., Kohli, S., Ghosh, S., Manoharan, J., Ranjan, S., Bock, F., Braun-Dullaeus, R. C., Esmon, C. T., Huber, T. B., et al. Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition Blood 2017 130:2664-2677 DOI:10.1182/blood-2017-05-782102 PMID:28882883
- Fernandez, J. A., Xu, X., Sinha, R. K., Mosnier, L. O., Sanner, M. F., Griffin, J. H. Activated protein C light chain provides an extended binding surface for its anticoagulant cofactor, protein S Blood Advances 2017 1:1423-1426 DOI:10.1182/bloodadvances.2017007005 PMID:29296783 PMCID:PMC5727852
- Healy, L. D., Puy, C., Fernandez, J. A., Mitrugno, A., Keshari, R. S., Taku, N. A., Chu, T. T., Xu, X., Gruber, A., Lupu, F., Griffin, J. H., McCarty, O. J. T. Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo Journal of Biological Chemistry 2017 292:8616-8629 DOI:10.1074/jbc.M116.768309 PMID:28408624 PMCID:PMC5448091
- Griffin, J. H., Mosnier, L. O., Fernandez, J. A., Zlokovic, B. V. 2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis. Thrombotic stroke: neuroprotective therapy by recombinant-activated protein C Arteriosclerosis Thrombosis and Vascular Biology 2016 36:2143-2151 DOI:10.1161/atvbaha.116.308038 PMID:27758767 PMCID:PMC5119536
- Deguchi, H., Sinha, R. K., Marchese, P., Ruggeri, Z. M., Zilberman-Rudenko, J., McCarty, O. J. T., Cohen, M. J., Griffin, J. H. Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va Blood 2016 128:1870-1878 DOI:10.1182/blood-2016-03-707679 PMID:27421960 PMCID:PMC5054698
- Wang, Y., Zhao, Z., Rege, S. V., Wang, M., Si, G., Zhou, Y., Wang, S., Griffin, J. H., Goldman, S. A., Zlokovic, B. V. 3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice Nature Medicine 2016 22:1050-1055 DOI:10.1038/nm.4154 PMID:27548576
- Burnier, L., Boroujerdi, A., Fernandez, J. A., Welser-Alves, J. V., Griffin, J. H., Milner, R. Physiological cerebrovascular remodeling in response to chronic mild hypoxia: A role for activated protein C Experimental Neurology 2016 283:396-403 DOI:10.1016/j.expneurol.2016.07.004 PMID:27412766 PMCID:PMC4992591
- Alsultan, A., Gale, A. J., Kurban, K., Khalifah, M., Albadr, F. B., Griffin, J. H. Activation-resistant homozygous protein C R229W mutation causing familial perinatal intracranial hemorrhage and delayed onset of thrombosis Thrombosis Research 2016 143:17-21 DOI:10.1016/j.thromres.2016.04.011 PMID:27172833 PMCID:PMC4943460
- Gale, A. J., Bhat, V., Pellequer, J. L., Griffin, J. H., Mosnier, L. O., Von Drygalski, A. Safety, stability and pharmacokinetic properties of (super)Factor Va, a novel engineered coagulation Factor V for treatment of severe bleeding Pharmaceutical Research 2016 33:1517-1526 DOI:10.1007/s11095-016-1895-3 PMID:26960296 PMCID:PMC4854778
- Griffin, J. H., Fernandez, J. A., Lyden, P. D., Zlokovic, B. V. Activated protein C promotes neuroprotection: mechanisms and translation to the clinic Thrombosis Research 2016 141:S62-S64 DOI:10.1016/S0049-3848(16)30368-1 PMID:27207428 PMCID:PMC4904825
- Sinha, R. K., Yang, X. V., Fernandez, J. A., Xu, X., Mosnier, L. O., Griffin, J. H. Apolipoprotein E receptor 2 mediates activated protein C-induced endothelial Akt activation and endothelial barrier stabilization Arteriosclerosis Thrombosis and Vascular Biology 2016 36:518-524 DOI:10.1161/atvbaha.115.306795 PMID:26800564 PMCID:PMC4816599
- Bhat, V., von Drygalski, A., Gale, A. J., Griffin, J. H., Mosnier, L. O. Improved coagulation and haemostasis in haemophilia with inhibitors by combinations of superFactor Va and Factor VIIa Thrombosis and Haemostasis 2016 115:551-561 DOI:10.1160/th15-07-0525 PMID:26466980 PMCID:PMC4775351
- Deguchi, H., Banerjee, Y., Elias, D. J., Griffin, J. H. Elevated CETP lipid transfer activity is associated with the risk of venous thromboembolism Journal of Atherosclerosis and Thrombosis 2016 23:1159-1167 DOI:10.5551/jat.32201 PMID:27169917 PMCID:PMC5064881
- Liang, H. P. H., Kerschen, E. J., Basu, S., Hernandez, I., Zogg, M., Jia, S., Hessner, M. J., Toso, R., Rezaie, A. R., Fernandez, J. A., Camire, R. M., Ruf, W., et al. Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice Blood 2015 126:2415-2423 DOI:10.1182/blood-2015-05-644401 PMID:26341257 PMCID:PMC4653768
- Banno, F., Kita, T., Fernandez, J. A., Yanamoto, H., Tashima, Y., Kokame, K., Griffin, J. H., Miyata, T. Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation Blood 2015 126:2247-2253 DOI:10.1182/blood-2015-06-653162 PMID:26251307 PMCID:PMC4635119
- Deguchi, H., Banerjee, Y., Trauger, S., Siuzdak, G., Kalisiak, E., Fernandez, J. A., Hoang, L., Tran, M., Yegneswaran, S., Elias, D. J., Griffin, J. H. Acylcarnitines are anticoagulants that inhibit factor Xa and are reduced in venous thrombosis, based on metabolomics data Blood 2015 126:1595-1600 DOI:10.1182/blood-2015-03-636761 PMID:26175037 PMCID:PMC4582336
- Amar, A. P., Griffin, J. H., Zlokovic, B. V. Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke Frontiers in Cellular Neuroscience 2015 9:344 DOI:10.3389/fncel.2015.00344 PMID:26388732 PMCID:PMC4556986
- Yegneswaran, S., Banerjee, Y., Fernandez, J. A., Deguchi, H., Griffin, J. H. Lyso-sulfatide binds factor Xa and inhibits thrombin generation by the prothrombinase complex PLoS One 2015 10:e0135025 DOI:10.1371/journal.pone.0135025 PMID:26263376 PMCID:PMC4532512
- Ivanisevic, J., Elias, D., Deguchi, H., Averell, P. M., Kurczy, M., Johnson, C. H., Tautenhahn, R., Zhu, Z., Watrous, J., Jain, M., Griffin, J., Patti, G. J., et al. Arteriovenous blood metabolomics: a readout of intra-tissue metabostasis Scientific Reports 2015 5:12757 DOI:10.1038/srep12757 PMID:26244428 PMCID:PMC4525490
- Griffin, J. H., Zlokovic, B. V., Mosnier, L. O. Activated protein C: biased for translation Blood 2015 125:2898-2907 DOI:10.1182/blood-2015-02-355974 PMID:25824691 PMCID:PMC4424414
- Liang, H. P. H., Kerschen, E. J., Hernandez, I., Basu, S., Zogg, M., Botros, F., Jia, S., Hessner, M. J., Griffin, J. H., Ruf, W., Weiler, H. EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice Blood 2015 125:2845-2854 DOI:10.1182/blood-2014-11-610717 PMID:25733582 PMCID:PMC4424632
- Mosnier, L. O., Zlokovic, B. V., Griffin, J. H. Cytoprotective-selective activated protein C therapy for ischaemic stroke Thrombosis and Haemostasis 2014 112:883-892 DOI:10.1160/th14-05-0448 PMID:25230930
- von Drygalski, A., Bhat, V., Gale, A. J., Burnier, L., Cramer, T. J., Griffin, J. H., Mosnier, L. O. An engineered Factor Va prevents bleeding induced by anticoagulant wt activated protein C PLoS One 2014 9:e104304 DOI:10.1371/journal.pone.0104304 PMID:25127130 PMCID:PMC4134195
- Deguchi, H., Elias, D. J., Trauger, S., Zhang, H. M., Kalisiak, E., Siuzdak, G., Griffin, J. H. Warfarin untargeted metabolomics study identifies novel procoagulant ethanolamide plasma lipids British Journal of Haematology 2014 165:409-412 DOI:10.1111/bjh.12720 PMID:24450944 PMCID:PMC3984601
- Winkler, E. A., Sengillo, J. D., Sagare, A. P., Zhao, Z., Ma, Q., Zuniga, E., Wang, Y., Zhong, Z., Sullivan, J. S., Griffin, J. H., Cleveland, D. W., Zlokovic, B. V. Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice Proceedings of the National Academy of Sciences of the United States of America 2014 111:E1035-E1042 DOI:10.1073/pnas.1401595111 PMID:24591593 PMCID:PMC3964055
- von Drygalski, A., Cramer, T. J., Bhat, V., Griffin, J. H., Gale, A. J., Mosnier, L. O. Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant Journal of Thrombosis and Haemostasis 2014 12:363-372 DOI:10.1111/jth.12489 PMID:24818532 PMCID:PMC4161283
- Deguchi, H., Elias, D. J., Griffin, J. H. Gain in translation: heme oxygenase-1 induced by activated protein C promotes thrombus resolution Journal of Thrombosis and Haemostasis 2014 12:90-92 DOI:10.1111/jth.12446 PMID:24406066 PMCID:PMC4062081
- Wang, Y., Zhao, Z., Chow, N., Rajput, P. S., Griffin, J. H., Lyden, P. D., Zlokovic, B. V. Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats Stroke 2013 44:3529-3536 DOI:10.1161/strokeaha.113.003350 PMID:24159062
- Lyden, P., Levy, H., Weymer, S., Pryor, K., Kramer, W., Griffin, J. H., Davis, T. P., Zlokovic, B. Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers Current Pharmaceutical Design 2013 19:7479-7485 PMID:24372304 PMCID:PMC4040367
- Mosnier, L. O., Fernandez, J. A., Davis, T. P., Zlokovic, B. V., Griffin, J. H. Influence of the 3K3A-activated protein C variant on the plasma clot lysis activity of t-PA and of t-PA on the variant's anticoagulant activity Journal of Thrombosis and Haemostasis 2013 11:2059-2062 DOI:10.1111/jth.12400 PMID:24034518 PMCID:PMC3850769
- Wang, Y., Sinha, R. K., Mosnier, L. O., Griffin, J. H., Zlokovic, B. V. Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice Blood Cells Molecules and Diseases 2013 51:104-108 DOI:10.1016/j.bcmd2013.02.009 PMID:23541526
- Heeb, M. J., Mesters, R. M., Fernandez, J. A., Hackeng, T. M., Nakasone, R. K., Griffin, J. H. Plasma protein S residues 37-50 mediate its binding to factor Va and inhibition of blood coagulation Thrombosis and Haemostasis 2013 110:275-282 DOI:10.1160/th12-12-0953 PMID:23892573 PMCID:PMC3733499
- Wang, Y., Zhao, Z., Chow, N., Ali, T., Griffin, J. H., Zlokovic, B. V. Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1 Brain Research 2013 1507:97-104 DOI:10.1016/j.brainres.2013.02.023 PMID:23438513 PMCID:PMC3739836
- Guo, H., Zhao, Z., Yang, Q., Wang, M., Bell, R. D., Wang, S., Chow, N., Davis, T. P., Griffin, J. H., Goldman, S. A., Zlokovic, B. V. An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway Journal of Neuroscience 2013 33:6181-6190 DOI:10.1523/jneurosci.4491-12.2013 PMID:23554499
- Burnier, L., Fernandez, J. A., Griffin, J. H. Antibody SPC-54 provides acute in vivo blockage of the murine protein C system Blood Cells, Molecules, and Diseases 2013 50:252-8 DOI:10.1016/j.bcmd.2013.01.002 PMID:23385154 PMCID:PMC3594351
- von Drygalski, A., Furlan-Freguia, C., Ruf, W., Griffin, J. H., Mosnier, L. O. Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor Arteriosclerosis, Thrombosis, and Vascular Biology 2013 33:769-776 DOI:10.1161/atvbaha.112.301082 PMID:23393392
- Deguchi, H., Elias, D. J., Navarro, S., Espana, F., Griffin, J. H. Elevated serum amyloid A is associated with venous thromboembolism Thrombosis and Haemostasis 2013 109:358-359 DOI:10.1160/th12-10-0722 PMID:23255027 PMCID:PMC3579663
- Mosnier, L. O., Sinha, R. K., Burnier, L., Bouwens, E. A., Griffin, J. H. Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46 Blood 2012 120:5237-5246 DOI:10.1182/blood-2012-08-452169 PMID:23149848 PMCID:PMC3537315
- Van de Vijver, P., Schmitt, M., Suylen, D., Scheer, L., Thomassen, Mclgd, Schurgers, L. J., Griffin, J. H., Koenen, R. R., Hackeng, T. M. Incorporation of disulfide containing protein modules into multivalent antigenic conjugates: Generation of antibodies against the thrombin-sensitive region of murine protein S Journal of the American Chemical Society 2012 134:19318-19321 DOI:10.1021/ja306993t PMID:23066897
- von Drygalski, A., Furlan-Freguia, C., Mosnier, L. O., Yegneswaran, S., Ruf, W., Griffin, J. H. Infrared fluorescence for vascular barrier breach in vivo - a novel method for quantitation of albumin efflux Thrombosis and Haemostasis 2012 108:981-991 DOI:10.1160/th12-03-0196 PMID:23052565 PMCID:PMC3597782
- Wang, Y. M., Zhang, Z. G., Chow, N., Davis, T. P., Griffin, J. H., Chopp, M., Zlokovic, B. V. An activated protein c analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents Stroke 2012 43:2444-2449 DOI:10.1161/strokeaha.112.658997 PMID:22811462 PMCID:PMC3429704
- Williams, P. D., Zlokovic, B. V., Griffin, J. H., Pryor, K. E., Davis, T. P. Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke Current Pharmaceutical Design 2012 18:4215-4222 DOI:10.2174/138161212802430413 PMID:22632606 PMCID:PMC3472038
- Geiger, H., Pawar, S. A., Kerschen, E. J., Nattamai, K. J., Hernandez, I., Liang, H. P. H., Fernandez, J. A., Cancelas, J. A., Ryan, M. A., Kustikova, O., Schambach, A., Fu, Q., et al. Pharmacological targeting of the thrombomodulin-activated protein c pathway mitigates radiation toxicity Nature Medicine 2012 18:1123-9 DOI:10.1038/nm.2813 PMID:22729286 PMCID:PMC3491776
- Hansen, J. B., Fernandez, J. A., Borch, K. H., Griffin, J. H., Brox, J. H., Braekkan, S. K. Activated protein C plasma levels in the fasting and postprandial states among patients with previous unprovoked venous thromboembolism Thrombosis Research 2012 129:502-507 DOI:10.1016/j.thromres.2011.06.026 PMID:21777953 PMCID:PMC3480311
- Griffin, J. H., Zlokovic, B. V., Mosnier, L. O. Protein c anticoagulant and cytoprotective pathways International Journal of Hematology 2012 95:333-345 DOI:10.1007/s12185-012-1059-0 PMID:22477541 PMCID:PMC3413316
- Madhusudhan, T., Wang, H. J., Straub, B. K., Grone, E., Zhou, Q. X., Shahzad, K., Muller-Krebs, S., Schwenger, V., Gerlitz, B., Grinnell, B. W., Griffin, J. H., Reiser, J., et al. Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes Blood 2012 119:874-883 DOI:10.1182/blood-2011-07-365973 PMID:22117049 PMCID:PMC3398751
- Raife, T. J., Dwyre, D. M., Stevens, J. W., Erger, R. A., Leo, L., Wilson, K. M., Fernandez, J. A., Wilder, J., Kim, H. S., Griffin, J. H., Maeda, N., Lentz, S. R. Human thrombomodulin knock-in mice reveal differential effects of human thrombomodulin on thrombosis and atherosclerosis Arteriosclerosis, Thrombosis, and Vascular Biology 2011 31:2509-2517 DOI:10.1161/atvbaha.111.236828 PMID:21885846 PMCID:PMC3202707
- Bir, N., Lafargue, M., Howard, M., Goolaerts, A., Roux, J., Carles, M., Cohen, M. J., Iles, K. E., Fernandez, J. A., Griffin, J. H., Pittet, J. F. Cytoprotective-selective activated protein C attenuates pseudomonas aeruginosa-induced lung injury in mice American Journal of Respiratory Cell and Molecular Biology 2011 45:632-641 DOI:10.1165/rcmb.2010-0397OC PMID:21257925 PMCID:PMC3175583
- Zlokovic, B. V., Griffin, J. H. Cytoprotective protein C pathways and implications for stroke and neurological disorders Trends in Neurosciences 2011 34:198-209 DOI:10.1016/j.tins.2011.01.005 PMID:21353711 PMCID:PMC3491752
- Guo, H. A., Barrett, T. M., Zhong, Z. H., Fernandez, J. A., Griffin, J. H., Freeman, R. S., Zlokovic, B. V. Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway Molecular Neurodegeneration 2011 6:13 DOI:10.1186/1750-1326-6-13 PMID:21291561 PMCID:PMC3042387
- Zhong, Z. H., Wang, Y. M., Guo, H. A., Sagare, A., Fernandez, J. A., Bell, R. D., Barrett, T. M., Griffin, J. H., Freeman, R. S., Zlokovic, B. V. Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region Journal of Neuroscience 2010 30:15521-15534 DOI:10.1523/jneurosci.4437-10.2010 PMID:21084607 PMCID:PMC3012432
- Cheung, M. C., Albers, J. J., Kennedy, H., Deguchi, H., Elias, D. J., Averell, P. M., Griffin, J. H., Marcovina, S. M. Association of Apo(a)isoform size with dyslipoproteinemia in male venous thrombosis patients Clinica Chimica Acta 2010 411:1279-1283 DOI:10.1016/j.cca.2010.05.012 PMID:20488173 PMCID:PMC3427714
- Kerschen, E., Hernandez, I., Zogg, M., Jia, S. A., Hessner, M. J., Fernandez, J. A., Griffin, J. H., Huettner, C. S., Castellino, F. J., Weiler, H. Activated protein C targets CD8(+) dendritic cells to reduce the mortality of endotoxemia in mice Journal of Clinical Investigation 2010 120:3167-3178 DOI:10.1172/jci42629 PMID:20714108 PMCID:PMC2929901
- Cramer, T. J., Griffin, J. H., Gale, A. J. Factor V is an anticoagulant cofactor for activated protein C during inactivation of factor Va Pathophysiology of Haemostasis and Thrombosis 2010 37:17-23 DOI:10.1159/000315141 PMID:20501981 PMCID:PMC2974842
- Fernandez, J. A., Heeb, M. J., Xu, X., Singh, I., Zlokovic, B. V., Griffin, J. H. Species-specific anticoagulant and mitogenic activities of murine protein S Haematologica-The Hematology Journal 2009 94:1721-1731 DOI:10.3324/haematol.2009.009233 PMID:19815836 PMCID:PMC2791928
- Zhong, Z. H., Ilieva, H., Hallagan, L., Bell, R., Singh, I., Paquette, N., Thiyagarajan, M., Deane, R., Fernandez, J. A., Lane, S., Zlokovic, A. B., Liu, T., et al. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells Journal of Clinical Investigation 2009 119:3437-3449 DOI:10.1172/jci38476 PMID:19841542 PMCID:PMC2769191
- Saller, F., Brisset, A. C., Tchaikovski, S. N., Azevedo, M., Chrast, R., Fernandez, J. A., Schapira, M., Hackeng, T. M., Griffin, J. H., Angelillo-Scherrer, A. Generation and phenotypic analysis of protein S-deficient mice Blood 2009 114:2307-2314 DOI:10.1182/blood-2009-03-209031 PMID:19567881 PMCID:PMC2745849
- Heeb, M. J., Prashun, D., Griffin, J. H., Bouma, B. N. Plasma protein S contains zinc essential for efficient activated protein C-independent anticoagulant activity and binding to factor Xa, but not for efficient binding to tissue factor pathway inhibitor FASEB Journal 2009 23:2244-2253 DOI:10.1096/fj.08-123174 PMID:19244162 PMCID:PMC2704590
- Mosnier, L. O., Zampolli, A., Kerschen, E. J., Schuepbach, R. A., Banerjee, Y., Fernandez, J. A., Yang, X. V., Riewald, M., Weiler, H., Ruggeri, Z. M., Griffin, J. H. Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant Blood 2009 113:5970-5978 DOI:10.1182/blood-2008-10-183327 PMID:19244160 PMCID:PMC2700330
- Schuepbach, R. A., Feistritzer, C., Fernandez, J. A., Griffin, J. H., Riewald, M. Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1 Thrombosis and Haemostasis 2009 101:724-733 DOI:10.1160/th08-10-0632 PMID:19350118 PMCID:PMC2680237
- Guo, H., Wang, Y. M., Singh, I., Liu, D., Fernandez, J. A., Griffin, J. H., Chow, N., Zlokovic, B. V. Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity Journal of Neurochemistry 2009 109:116-124 DOI:10.1111/j.1471-4159.2009.05921.x PMID:19166505 PMCID:PMC2692505
- Cheung, M. C., Wolfbauer, G., Deguchi, H., Fernandez, J. A., Griffin, J. H., Albers, J. J. Human plasma phospholipid transfer protein specific activity is correlated with HDL size: Implications for lipoprotein physiology Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids 2009 1791:206-211 DOI:10.1016/j.bbalip.2008.12.010 PMID:19162221 PMCID:PMC2733856
- Guo, H., Singh, I., Wang, Y. M., Deane, R., Barrett, T., Fernandez, J. A., Chow, N., Griffin, J. H., Zlokovic, B. V. Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity European Journal of Neuroscience 2009 29:1119-1130 DOI:10.1111/j.1460-9568.2009.06664.x PMID:19302148 PMCID:PMC2692517
- Yang, X. V., Banerjee, Y., Fernandez, J. A., Deguchi, H., Xu, X., Mosnier, L. O., Urbanus, R. T., de Groot, P. G., White-Adams, T. C., McCarty, O. J. T., Griffin, J. H. Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells Proceedings of the National Academy of Sciences of the United States of America 2009 106:274-279 DOI:10.1073/pnas.0807594106 PMID:19116273 PMCID:PMC2629184
- Yegneswaran, S., Nguyen, P. M., Gale, A. J., Griffin, J. H. Prothrombin amino terminal region helps protect coagulation factor Va from proteolytic inactivation by activated protein C Thrombosis and Haemostasis 2009 101:55-61 DOI:10.1160/th08-07-0491 PMID:19132189 PMCID:PMC2730196
- Yegneswaran, S., Hackeng, T. M., Dawson, P. E., Griffin, J. H. The thrombin-sensitive region of protein S mediates phospholipid-dependent interaction with factor Xa Journal of Biological Chemistry 2008 283:33046-33052 DOI:10.1074/jbc.M806527200 PMID:18784085 PMCID:PMC2586267
- Thiyagarajan, M., Fernandez, J. A., Lane, S. M., Griffin, J. H., Zlokovic, B. V. Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1 Journal of Neuroscience 2008 28:12788-12797 DOI:10.1523/jneurosci.3485-08.2008 PMID:19036971 PMCID:PMC2742231
- Pecheniuk, N. M., Elias, D. J., Deguchi, H., Averell, P. M., Griffin, J. H. Elevated plasma fibronectin levels associated with venous thromboembolism Thrombosis and Haemostasis 2008 100:224-228 DOI:10.1160/th08-02-0078 PMID:18690341 PMCID:PMC2909754
- Heeb, M. J., Gandrille, S., Fernandez, J. A., Griffin, J. H., Fedullo, P. F. Late onset thrombosis in a case of severe protein S deficiency due to compound heterozygosity for PROS1 mutations Journal of Thrombosis and Haemostasis 2008 6:1235-1237 DOI:10.1111/j.1538-7836.2008.02994.x PMID:18433462 PMCID:PMC2632602
- White, T. C., Berny, M. A., Tucker, E. I., Urbanus, R. T., De Groot, P. G., Fernandez, J. A., Griffin, J. H., Gruber, A., McCarty, O. J. T. Protein C supports platelet binding and activation under flow: Role of glycoprotein Ib and apolipoprotein E receptor 2 Journal of Thrombosis and Haemostasis 2008 6:995-1002 DOI:10.1111/j.1538-7836.2008.02979.x PMID:18489431
- Pecheniuk, N. M., Elias, D. J., Xu, X., Griffin, J. H. Failure to validate association of gene polymorphisms in EPCR, PAR-1, FSAP and protein S Tokushima with venous thromboembolism among Californians of European ancestry Thrombosis and Haemostasis 2008 99:453-455 DOI:10.1160/th07-10-0607 PMID:18278202
- Deguchi, H., Fernandez, J. A., Griffin, J. H. Plasma cholesteryl ester transfer protein and blood coagulability Thrombosis and Haemostasis 2007 98:1160-1164 DOI:10.1160/th07-07-0451 PMID:18064308
- Mosnier, L. O., Yang, X. V., Griffin, J. H. Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions Journal of Biological Chemistry 2007 282:33022-33033 DOI:10.1074/jbc.M705824200 PMID:17872949
- Kerschen, E. J., Fernandez, J. A., Cooley, B. C., Yang, X. V., Sood, R., Mosnier, L. O., Castellino, F. J., Mackman, N., Griffin, J. H., Weiler, H. Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C Journal of Experimental Medicine 2007 204:2439-2448 DOI:10.1084/jem.20070404 PMID:17893198 PMCID:PMC2118455
- Yegneswaran, S., Kojima, Y., Nguyen, P. M., Gale, A. J., Heeb, M. J., Griffin, J. H. Factor Va residues 311-325 represent an activated protein C binding region Journal of Biological Chemistry 2007 282:28353-28361 DOI:10.1074/jbc.M704316200 PMID:17646160
- Gale, A. J., Yegneswaran, S., Xu, X., Pellequer, J. L., Griffin, J. H. Characterization of a factor Xa binding site on factor Va near the Arg-506 activated protein C cleavage site Journal of Biological Chemistry 2007 282:21848-21855 DOI:10.1074/jbc.M702192200 PMID:17553804
- Griffin, J. H., Fernandez, J. A., Gale, A. J., Mosnier, L. O. Activated protein C Journal of Thrombosis and Haemostasis 2007 5:73-80 DOI:10.1111/j.1538-7836.2007.02491.x PMID:17635713
- Gruber, A., Marzec, U. M., Bush, L., Di Cera, E., Fernandez, J. A., Berny, M. A., Tucker, E. I., McCarty, O. J. T., Griffin, J. H., Hanson, S. R. Relative antithrombotic and andhernostatic effects of protein C activator versus low-molecular-weight heparin in primates Blood 2007 109:3733-3740 DOI:10.1182/blood-2006-07-035147 PMID:17227834 PMCID:PMC1874578
- Mosnier, L. O., Zlokovic, B. V., Griffin, J. H. The cytoprotective protein C pathway Blood 2007 109:3161-3172 DOI:10.1182/blood-2006-09-003004 PMID:17110453
- Eichinger, S., Pecheniuk, N. M., Hron, G., Deguchi, H., Schemper, M., Kyrle, P. A., Griffin, J. H. High-density lipoprotein and the risk of recurrent venous thromboembolism Circulation 2007 115:1609-1614 DOI:10.1161/circulationaha.106.649954 PMID:17372172
- Raivio, P., Fernandez, J. A., Kuitunen, A., Griffin, J. H., Lassila, R., Petaja, J. Activation of protein C and hemodynamic recovery after coronary artery bypass surgery Journal of Thoracic and Cardiovascular Surgery 2007 133:44-51 DOI:10.1016/j.jtcvs.2006.10.003 PMID:17198779
- Radtke, K. P., Griffin, J. H., Riceberg, J., Gale, A. J. Disulfide bond-stabilized factor viii has prolonged factor viiia activity and improved potency in whole blood clotting assays Journal of Thrombosis and Haemostasis 2007 5:102-108 DOI:10.1111/j.1538-7836.2006.02283.x
- Cheng, T., Petraglia, A. L., Li, Z., Thiyagarajan, M., Zhong, Z. H., Wu, Z. H., Liu, D., Maggirwar, S. B., Deane, R., Fernandez, J. A., LaRue, B., Griffin, J. H., et al. Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage Nature Medicine 2006 12:1278-1285 DOI:10.1038/nm1498 PMID:17072311
- Pecheniuk, N. M., Deguchi, H., Elias, D. J., Xu, X., Griffin, J. H. Cholesteryl ester transfer protein genotypes associated with venous thrombosis and dyslipoproteinemia in males Journal of Thrombosis and Haemostasis 2006 4:2080-2082 DOI:10.1111/j.1538-7836.2006.02099.x PMID:16961620
- Mosnier, L. O., Griffin, J. H. Protein C anticoagulant activity in relation to anti-inflammatory and anti-apoptotic activities Frontiers in Bioscience 2006 11:2381-2399 DOI:10.2741/1977 PMID:16720321
- Fernandez, J. A., Lentz, S. R., Dwyre, D. M., Griffin, J. H. A novel ELISA for mouse activated protein C in plasma Journal of Immunological Methods 2006 314:174-181 DOI:10.1016/j.jim.2006.05.004 PMID:16828789
- Feistritzer, C., Schuepbach, R. A., Mosnier, L. O., Bush, L. A., Di Cera, E., Griffin, J. H., Riewald, M. Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells Journal of Biological Chemistry 2006 281:20077-20084 DOI:10.1074/jbc.M600506200 PMID:16709569
- Mineo, C., Deguchi, H., Griffin, J. H., Shaul, P. W. Endothelial and antithrombotic actions of HDL Circulation Research 2006 98:1352-1364 DOI:10.1161/01.res.0000225982.01988.93 PMID:16763172
- Gale, A. J., Radtke, K. P., Cunningham, M. A., Chamberlain, D., Pellequer, J. L., Griffin, J. H. Intrinsic stability and functional properties of disulfide bond-stabilized coagulation factor VIIIa variants Journal of Thrombosis and Haemostasis 2006 4:1315-1322 DOI:10.1111/j.1538-7836.2006.01951.x PMID:16706977
- Bushnell, C. D., Griffin, J., Newby, L. K., Goldstein, L. B., Mahaffey, K. W., Graffagnino, C. A., Harrington, R. A., White, H. D., Simes, R. J., Califf, R. M., Topol, E. J., Easton, J. D. Statin use and sex-specific stroke outcomes in patients with vascular disease Stroke 2006 37:1427-1431 DOI:10.1161/01.STR.0000221315.60282.ca PMID:16645137
- Fernandez, J. A., Pecheniuk, N. M., Deguchi, H., Elias, D. J., Griffin, J. H. Is adiponectin implicated in venous thromboembolism? Journal of Thrombosis and Haemostasis 2006 4:1151-1152 DOI:10.1111/j.1538-7836.2006.01897.x PMID:16689775
- Fernandez, J. A., Vento, A. E., Jormalainen, M., Griffin, J. H., Pseonen, E., Syrjala, M., Repo, H., Jansson, S. E., Ramo, O. J., Petaja, J. Activated protein C in the cardioplegic solution on a porcine model of coronary ischemia-reperfusion has deleterious hemodynamic effects Cardiovascular Drugs and Therapy 2006 20:113-121 DOI:10.1007/s10557-006-7448-y PMID:16761191
- Griffin, J. H., Fernandez, J. A., Mosnier, L. O., Liu, D., Cheng, T., Guo, H., Zlokovic, B. V. The promise of protein C Blood Cells Molecules and Diseases 2006 36:211-216 DOI:10.1016/j,bcmd.2005.12.023 PMID:16464623
- Ilmakunnas, M., Pesonen, E. J., Hockerstedt, K., Makisalo, H., Fernandez, J. A., Griffin, J. H., Repo, H., Siitonen, S., Petaja, J. Graft protein C entrapment is associated with reduced phagocyte activation during reperfusion in human liver transplantation Critical Care Medicine 2006 34:426-432 DOI:10.1097/01.ccm.0000198108.38349.28 PMID:16424724
- Gruber, A., Fernandez, J. A., Bush, L., Marzec, U., Griffin, J. H., Hanson, S. R., Di Cera, E. Limited generation of activated protein C during infusion of the protein C activator thrombin analog W215A/E217A in primates Journal of Thrombosis and Haemostasis 2006 4:392-397 DOI:10.1111/j.1538-7836.2006.01760.x PMID:16420571
- Tanaka, K. A., Fernandez, J. A., Marzec, U. M., Kelly, A. B., Mohri, M., Griffin, J. H., Hanson, S. R., Gruber, A. Soluble thrombomodulin is antithrombotic in the presence of neutralising antibodies to protein C and reduces circulating activated protein C levels in primates British Journal of Haematology 2006 132:197-203 DOI:10.1111/j.1365-2141.2005.05855.x PMID:16398653
- Lindstrom, O., Kylanpaa, L., Mentula, P., Puolakkainen, P., Kemppainen, E., Haapiainen, R., Fernandez, J. A., Griffin, J. H., Repo, H., Petaja, J. Upregulated but insufficient generation of activated protein C is associated with development of multiorgan failure in severe acute pancreatitis Critical Care 2006 10:R16 DOI:10.1186/cc3966 PMID:16420659 PMCID:PMC1550818
- Turunen, A. J., Fernandez, J. A., Lindgren, L., Salmela, K. T., Kyllonen, L. E., Makisalo, H., Griffin, J. H., Siitonen, S. M., Petaja, J., Pesonen, E. J. Activated protein C reduces graft neutrophil activation in clinical renal transplantation American Journal of Transplantation 2005 5:2204-2212 DOI:10.1111/j.1600-6143.2005.00994.x PMID:16095499
- Zlokovic, B. V., Zhang, C. L., Liu, D., Fernandez, J., Griffin, J. H., Chopp, M. Functional recovery after embolic stroke in rodents by activated protein C Annals of Neurology 2005 58:474-477 DOI:10.1002/ana.20602 PMID:16130108
- Deguchi, H., Pecheniuk, N. M., Elias, D. J., Averell, P. M., Griffin, J. H. High-density lipoprotein deficiency and dyslipoproteinemia associated with venous thrombosis in men Circulation 2005 112:893-899 DOI:10.1161/circulationaha.104.521344 PMID:16087810
- Deguchi, H., Bouma, B. N., Middeldorp, S., Lee, Y. M., Griffin, J. H. Decreased plasma sensitivity to activated protein C by oral contraceptives is associated with decreases in plasma glucosylceramide Journal of Thrombosis and Haemostasis 2005 3:935-938 DOI:10.1111/j.1538-7836.2005.01335.x PMID:15869587
- Pecheniuk, N. M., Deguchi, H., Griffin, J. H. Cholesterol enhances phospholipid-dependent activated protein c anticoagulant activity Journal of Thrombosis and Haemostasis 2005 3:340-345 DOI:10.1111/j.1538-7836.2005.01112.x PMID:15670041
- Liu, D., Cheng, T., Guo, H., Fernandez, J. A., Griffin, J. H., Song, X. M., Zlokovic, B. V. Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C Nature Medicine 2004 10:1379-1383 DOI:10.1038/nm1122 PMID:15516929
- Yegneswaran, S., Mesters, R. M., Fernandez, J. A., Griffin, J. H. Prothrombin residues 473-487 contribute to factor Va binding in the prothrombinase complex Journal of Biological Chemistry 2004 279:49019-49025 DOI:10.1074/jbc.M406654200 PMID:15331602 PMCID:PMC2911622
- Contreras, J. L., Eckstein, C., Smyth, C. A., Bilbao, G., Vilatoba, M., Ringland, S. E., Young, C., Thompson, J. A., Fernandez, J. A., Griffin, J. H., Eckhoff, D. E. Activated protein C preserves functional islet mass after intraportal transplantation - a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death Diabetes 2004 53:2804-2814 DOI:10.2337/diabetes.53.11.2804 PMID:15504960
- Leiba, M., Seligsohn, U., Sidi, Y., Harats, D., Sela, B. A., Griffin, J. H., Livneh, A., Rosenberg, N., Gelernter, I., Gur, H., Ehrenfeld, M. Thrombophilic factors are not the leading cause of thrombosis in Behcet's disease Annals of the Rheumatic Diseases 2004 63:1445-1449 DOI:10.1136/ard.2003.014241 PMID:15479893 PMCID:PMC1754810
- Mosnier, L. O., Gale, A. J., Yegneswaran, S., Griffin, J. H. Activated protein C variants with normal cytoprotective but reduced anticoagulant activity Blood 2004 104:1740-1744 DOI:10.1182/blood-2004-01-0110 PMID:15178575
- Griffin, J. H., Fernandez, J. A., Liu, D., Cheng, T., Guo, H., Zlokovic, B. V. Activated protein C and ischemic stroke Critical Care Medicine 2004 32:S247-S253 DOI:10.1097/01.cmm.0000126127.87484.2b PMID:15118526
- Deguchi, H., Yegneswaran, S., Griffin, J. H. Sphingolipids as bioactive regulators of thrombin generation Journal of Biological Chemistry 2004 279:12036-12042 DOI:10.1074/jbc.M302531200 PMID:14722105
- Guo, H., Liu, D., Gelbard, H., Cheng, T., Insalaco, R., Fernandez, J. A., Griffin, J. H., Zlokovic, B. V. Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3 Neuron 2004 41:563-572 DOI:10.1016/s0896-6273(04)00019-4 PMID:14980205
- Gale, A. J., Griffin, J. H. Characterization of a thrombomodulin binding site on protein C and its comparison to an activated protein C binding site for factor Va Proteins-Structure Function and Genetics 2004 54:433-441 DOI:10.1002/prot.10627 PMID:14747992
- Yegneswaran, S., Mesters, R. M., Griffin, J. H. Identification of distinct sequences in human blood coagulation factor Xa and prothrombin essential for substrate and cofactor recognition in the prothrombinase complex Journal of Biological Chemistry 2003 278:33312-33318 DOI:10.1074/jbc.M305906200 PMID:12805370
- Mosnier, L. O., Griffin, J. H. Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor Biochemical Journal 2003 373:65-70 DOI:10.1042/bj20030341 PMID:12683950
- Slungaard, A., Fernandez, J. A., Griffin, J. H., Key, N. S., Long, J. R., Piegors, D. J., Lentz, S. R. Platelet factor 4 enhances generation of activated protein C in vitro and in vivo Blood 2003 102:146-151 DOI:10.1182/blood-2002-11-3529 PMID:12609838
- Domotor, E., Benzakour, O., Griffin, J. H., Yule, D., Fukudome, K., Zlokovic, B. V. Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1 Blood 2003 101:4797-4801 DOI:10.1182/blood-2002-12-3680 PMID:12586611
- Fernandez, J. A., Xu, X., Liu, D., Zlokovic, B. V., Griffin, J. H. Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model Blood Cells Molecules and Diseases 2003 30:271-276 DOI:10.1016/s1079-9796(03)00034-2 PMID:12737945
- Yegneswaran, S., Deguchi, H., Griffin, J. H. Glucosylceramide, a neutral glycosphingolipid anticoagulant cofactor, enhances the interaction of human- and bovine-activated protein C with negatively charged phospholipid vesicles Journal of Biological Chemistry 2003 278:14614-14621 DOI:10.1074/jbc.M206746200 PMID:12560338
- Liu, D., Guo, H., Griffin, J. H., Fernandez, J. A., Zlokovic, B. V. Protein S confers neuronal protection during ischemic/hypoxic injury in mice Circulation 2003 107:1791-1796 DOI:10.1161/01.cir.0000058460.34453.5a PMID:12665496
- Cheng, T., Liu, D., Griffin, J. H., Fernandez, J. A., Castellino, F., Rosen, E. D., Fukudome, K., Zlokovic, B. V. Activated protein c blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective Nature Medicine 2003 9:338-342 DOI:10.1038/nm826 PMID:12563316
- Ilmakunnas, M., Petaja, J., Hockerstedt, K., Makisalo, H., Fernandez, J. A., Griffin, J. H., Jansson, S. E., Repo, H., Pesonen, E. J. Activation of protein C during reperfusion in clinical liver transplantation Transplantation 2003 75:467-472 DOI:10.1097/01.tp.0000046529.83650.8a PMID:12605111
- Simmelink, M. J. A., de Groot, P. G., Derksen, Rhwm, Fernandez, J. A., Griffin, J. H. Oral anticoagulation reduces activated protein C less than protein C and other vitamin K-dependent clotting factors Blood 2002 100:4232-4233 DOI:10.1182/blood-2002-01-0329 PMID:12393585
- Khrenov, A. V., Ananyeva, N. M., Griffin, J. H., Saenko, E. L. Coagulation pathways in atherothrombosis Trends in Cardiovascular Medicine 2002 12:317-324 DOI:10.1016/s1050-1738(02)00182-2 PMID:12458095
- Lentz, S. R., Piegors, D. J., Fernandez, J. A., Erger, R. A., Arning, E., Malinow, M. R., Griffin, J. H., Bottiglieri, T., Haynes, W. G., Heistad, D. D. Effect of hyperhomocysteinemia on protein C activation and activity Blood 2002 100:2108-2112 DOI:10.1182/blood-2002-03-0727 PMID:12200374
- Heeb, M. J., Griffin, J. H. Activated protein C-dependent and -independent anticoagulant activities of protein S have different structural requirements Blood Cells Molecules and Diseases 2002 29:190-199 DOI:10.1006/bcmd.2002.0558 PMID:12490286
- Gale, A. J., Xu, X., Pellequer, J. L., Getzoff, E. D., Griffin, J. H. Interdomain engineered disulfide bond permitting elucidation of mechanisms of inactivation of coagulation factor Va by activated protein C Protein Science 2002 11:2091-2101 DOI:10.1110/ps.0210002 PMID:12192065 PMCID:PMC2373598
- Heeb, M. J., Paganini-Hill, A., Griffin, J. H., Fisher, M. Low protein Z levels and risk of ischemic stroke: differences by diabetic status and gender Blood Cells Molecules and Diseases 2002 29:139-144 DOI:10.1006/bcmd.2002.0549 PMID:12490280
- Lentz, S. R., Miller, F. J., Piegors, D. J., Erger, R. A., Fernandez, J. A., Griffin, J. H., Heistad, D. D. Anticoagulant responses to thrombin are enhanced during regression of atherosclerosis in monkeys Circulation 2002 106:842-846 DOI:10.1161/01.cir.0000024982.11646.25 PMID:12176958
- Gale, A. J., Tsavaler, A., Griffin, J. H. Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C Journal of Biological Chemistry 2002 277:28836-28840 DOI:10.1074/jbc.M204363200 PMID:12063259
- Kottke-Marchant, K., Bahit, M. C., Granger, C. B., Zoldhelyi, P., Ardissino, D., Brooks, L., Griffin, J. H., Potthoff, R. F., Van de Werf, F., Califf, R. M., Topol, E. J. Effect of hirudin vs heparin on haemostatic activity in patients with acute coronary syndromes - the GUSTO-IIb haemostasis substudy European Heart Journal 2002 23:1202-1212 DOI:10.1053/euhj.2001.3074 PMID:12127922
- Griffin, J. H., Zlokovic, B., Fernandez, J. A. Activated protein C: Potential therapy for severe sepsis, thrombosis, and stroke Seminars in Hematology 2002 39:197-205 DOI:10.1053/shem.2002.2002.34093 PMID:12124682
- Fernandez, J. A., Gruber, A., Heeb, M. J., Griffin, J. H. Protein C pathway impairment in nonsymptomatic cigarette smokers Blood Cells Molecules and Diseases 2002 29:73-82 DOI:10.1006/bcmd.2002.0542 PMID:12482406
- Simmelink, M. J. A., Fernandez, J. A., Derksen, Rhwm, Griffin, J. H., de Groot, P. G. Low levels of activated protein C in patients with systemic lupus erythematosus do not relate to lupus anticoagulants but to low levels of factor II British Journal of Haematology 2002 117:676-684 DOI:10.1046/j.1365-2141.2002.03447.x PMID:12028041
- Yegneswaran, S., Fernandez, J. A., Griffin, J. H., Dawson, P. E. Factor Va increases the affinity of factor Xa for prothrombin: a binding study using a novel photoactivable thiol-specific fluorescent probe Chemistry & Biology 2002 9:485-494 DOI:10.1016/s1074-5521(02)00132-1 PMID:11983337
- Deguchi, H., Fernandez, J. A., Griffin, J. H. Neutral glycosphingolipid-dependent inactivation of coagulation factor Va by activated protein C and protein S Journal of Biological Chemistry 2002 277:8861-8865 DOI:10.1074/jbc.M110252200 PMID:11741960
- Petaja, J., Pesonen, E., Fernandez, J. A., Griffin, J. H., Repo, H., Jansson, S. E., Vento, A. E., Ramo, O. J. Activated protein C and inflammation in human myocardium after heart surgery American Journal of Hematology 2001 67:210-212 DOI:10.1002/ajh.1110 PMID:11391722
- Griffin, J. H., Fernandez, J. A., Deguchi, H. Plasma lipoproteins, hemostasis and thrombosis Thrombosis and Haemostasis 2001 86:386-394 PMID:11487028
- Shibata, M., Kumar, S. R., Amar, A., Fernandez, J. A., Hofman, F., Griffin, J. H., Zlokovic, B. V. Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke Circulation 2001 103:1799-1805 PMID:11282913
- Deguchi, H., Fernandez, J. A., Pabinger, I., Heit, J. A., Griffin, J. H. Plasma glucosylceramide deficiency as potential risk factor for venous thrombosis and modulator of anticoagulant protein C pathway Blood 2001 97:1907-1914 DOI:10.1182/blood.V97.7.1907 PMID:11264150
- Grody, W. W., Griffin, J. H., Taylor, A. K., Korf, B. R., Heit, J. A. American College of Medical Genetics consensus statement on factor V Leiden mutation testing Genetics in Medicine 2001 3:139-148 DOI:10.109700125817-200103000-00009 PMID:11280951 PMCID:PMC3111091
- Rintelen, C., Yegneswaran, S., Griffin, J. H. Anticoagulant dysfunction of human Arg352Trp-activated protein C caused by defective factor Va inactivation Thrombosis and Haemostasis 2001 85:274-279 PMID:11246547
- Hackeng, T. M., Fernandez, J. A., Dawson, P. E., Kent, S. B. H., Griffin, J. H. Chemical synthesis and spontaneous folding of a multidomain protein: anticoagulant microprotein S Proceedings of the National Academy of Sciences of the United States of America 2000 97:14074-14078 DOI:10.1073/pnas.260239797 PMID:11106381 PMCID:PMC18873
- Pellequer, J. L., Gale, A. J., Getzoff, E. D., Griffin, J. H. Three-dimensional model of coagulation factor Va bound to activated protein C Thrombosis and Haemostasis 2000 84:849-857 PMID:11127867
- Hackeng, T. M., Yegneswaran, S., Johnson, A. E., Griffin, J. H. Conformational changes in activated protein C caused by binding of the first epidermal growth factor-like module of protein S Biochemical Journal 2000 349:757-764 PMID:10903136 PMCID:PMC1221202
- Gale, A. J., Heeb, M. J., Griffin, J. H. The autolysis loop of activated protein C interacts with factor Va and differentiates between the Arg506 and Arg306 cleavage sites Blood 2000 96:585-593 PMID:10887122
- Mesters, R. M., Helterbrand, J., Utterback, B. G., Yan, S. B., Chao, Y. B., Fernandez, J. A., Griffin, J. H., Hartman, D. L. Prognostic value of protein C concentrations in neutropenic patients at high risk of severe septic complications Critical Care Medicine 2000 28:2209-2216 PMID:10921542
- Marx, P. F., Hackeng, T. M., Dawson, P. E., Griffin, J. H., Meijers, J. C. M., Bouma, B. N. Inactivation of active thrombin-activable fibrinolysis inhibitor takes place by a process that involves conformational instability rather than proteolytic cleavage Journal of Biological Chemistry 2000 275:12410-12415 DOI:10.1074/jbc.275.17.12410 PMID:10777524
- Fernandez, J. A., Kojima, K., Petaja, J., Hackeng, T. M., Griffin, J. H. Cardiolipin enhances protein C pathway anticoagulant activity Blood Cells Molecules and Diseases 2000 26:115-123 DOI:10.1006/bcmd.2000.0285 PMID:10753602
- Deguchi, H., Fernandez, J. A., Hackeng, T. M., Banka, C. L., Griffin, J. H. Cardiolipin is a normal component of human plasma lipoproteins Proceedings of the National Academy of Sciences of the United States of America 2000 97:1743-1748 DOI:10.1073/pnas.97.4.1743 PMID:10677528
- Griffin, J. H., Deguchi, H., Fernandez, J. A. Causes of thrombophilia yet to be discovered: A personal view Haemostasis 2000 30:26-33 PMID:11251338
- Griffin, J. H. Regulation of coagulation by the antithrombotic protein C pathway Archives of Hellenic Medicine 2000 17:19-25
- Gale, A. J., Pellequer, J. L., Getzoff, E. D., Griffin, J. H. Structural basis for hemophilia A caused by mutations in the C domains of blood coagulation factor VIII Thrombosis and Haemostasis 2000 83:78-85 PMID:10669159
- Heeb, M. J., Kojima, Y., Rosing, J., Tans, G., Griffin, J. H. C-terminal residues 621-635 of protein S are essential for binding to factor Va Journal of Biological Chemistry 1999 274:36187-36192 DOI:10.1074/jbc.274.51.36187 PMID:10593904
- Bouma, B. N., Mosnier, L. O., Meijers, J. C. M., Griffin, J. H. Factor XI dependent and independent activation of thrombin activatable fibrinolysis inhibitor (TAFI) in plasma associated with clot formation Thrombosis and Haemostasis 1999 82:1703-1708 PMID:10613658
- Fernandez, J. A., Petaja, J., Griffin, J. H. Dermatan sulfate and LMW heparin enhance the anticoagulant action of activated protein C Thrombosis and Haemostasis 1999 82:1462-1468 PMID:10595639
- Tabrizi, P., Wang, L., Seeds, N., McComb, J. G., Yamada, S., Griffin, J. H., Carmeliet, P., Weiss, M. H., Zlokovic, B. V. Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model - studies in tPA-deficient mice and wild-type mice on a matched genetic background Arteriosclerosis, Thrombosis, and Vascular Biology 1999 19:2801-2806 PMID:10559029
- Petaja, J., Pesonen, E., Fernandez, J. A., Vento, A. E., Ramo, O. J., Griffin, J. H. Cardiopulmonary bypass and activation of antithrombotic plasma protein C Journal of Thoracic and Cardiovascular Surgery 1999 118:422-429 DOI:10.1016/s0022-5223(99)70178-9 PMID:10469954
- Hackeng, T. M., Griffin, J. H., Dawson, P. E. Protein synthesis by native chemical ligation: expanded scope by using straightforward methodology Proceedings of the National Academy of Sciences of the United States of America 1999 96:10068-10073 DOI:10.1073/pnas.96.18.10068 PMID:10468563 PMCID:PMC17843
- Zivelin, A., Gitel, S., Griffin, J. H., Xu, X., Fernandez, J. A., Martinowitz, U., Cohen, Y., Halkin, H., Seligsohn, U., Inbal, A. Extensive venous and arterial thrombosis associated with an inhibitor to activated protein c Blood 1999 94:895-901 PMID:10419879
- Lentz, S. R., Fernandez, J. A., Griffin, J. H., Piegors, D. J., Erger, R. A., Malinow, M. R., Heistad, D. D. Impaired anticoagulant response to infusion of thrombin in atherosclerotic monkeys associated with acquired defects in the protein c system Arteriosclerosis, Thrombosis, and Vascular Biology 1999 19:1744-1750 PMID:10397693
- Xu, X., Bauer, K. A., Griffin, J. H. Two multiplex pcr-based DNA assays for the thrombosis risk factors prothrombin G20210A and coagulation factor V G1691A polymorphisms Thrombosis Research 1999 93:265-269 DOI:10.1016/s0049-3848(98)00178-9 PMID:10093967
- Macko, R. F., Killewich, L. A., Fernandez, J. A., Cox, D. K., Gruber, A., Griffin, J. H. Brain-specific protein C activation during carotid artery occlusion in humans Stroke 1999 30:542-545 PMID:10066849
- Griffin, J. H., Kojima, K., Banka, C. L., Curtiss, L. K., Fernandez, J. A. High-density lipoprotein enhancement of anticoagulant activities of plasma protein S and activated protein C Journal of Clinical Investigation 1999 103:219-227 DOI:10.1172/jci5006 PMID:9916134
- Pellequer, J. L., Gale, A. J., Griffin, J. H., Getzoff, E. D. Homology models of the C domains of blood coagulation factors V and VIII: A proposed membrane binding mode for FV and FVIII C2 domains Blood Cells Molecules and Diseases 1998 24:448-461 DOI:10.1006/bcmd.1998.0214 PMID:9880241
- Petaja, J., Fernandez, J. A., Fellman, V., Griffin, J. H. Upregulation of the antithrombotic protein C pathway at birth Pediatric Hematology and Oncology 1998 15:489-499 PMID:9842642
- Mounier, C. M., Hackeng, T. M., Schaeffer, F., Faure, G., Bon, C., Griffin, J. H. Inhibition of prothrombinase by human secretory phospholipase A2 involves binding to factor Xa Journal of Biological Chemistry 1998 273:23764-23772 DOI:10.1074/jbc.273.37.23764 PMID:9726985
- Hackeng, T. M., Dawson, P. E., Kent, S. B. H., Griffin, J. H. Chemical synthesis of human protein S thrombin-sensitive module and first epidermal growth factor module Biopolymers 1998 46:53-63 DOI:10.1002/(sici)1097-0282(199808)46:2<53::aid-bip1>3.3.co;2-6 PMID:9664841
- Kojima, Y., Heeb, M. J., Gale, A. J., Hackeng, T. M., Griffin, J. H. Binding site for blood coagulation factor Xa involving residues 311-325 in factor Va Journal of Biological Chemistry 1998 273:14900-14905 DOI:10.1074/jbc.273.24.14900 PMID:9614093
- Fernandez, J. A., Griffin, J. H., Chang, G. T. G., Stam, J., Reitsma, P. H., Bertina, R. M., Bouma, B. N. Involvement of amino acid residues 423-429 of human protein S in binding to C4b-binding protein Blood Cells Molecules and Diseases 1998 24:101-113 DOI:10.1006/bcmd.1998.0175 PMID:9628846
- Petaja, J., Hakala, L., Rasi, V., Griffin, J. H. Circulating activated protein C in subjects with heterozygous GIn506-factor V Haemostasis 1998 28:31-36 PMID:9885368
- Petaja, J. M., Griffin, J. H. Activated protein C resistance: What have we learned now that the dust has settled? Annals of Medicine 1997 29:469-472 DOI:10.3109/07853899709007469 PMID:9562511
- Wang, L. L., Zoppe, M., Hackeng, T. M., Griffin, J. H., Lee, K. F., Verma, I. M. A factor IX-deficient mouse model for hemophilia B gene therapy Proceedings of the National Academy of Sciences of the United States of America 1997 94:11563-11566 DOI:10.1073/pnas.94.21.11563 PMID:9326649
- Smiley, S. T., Boyer, S. N., Heeb, M. J., Griffin, J. H., Grusby, M. J. Protein S is inducible by interleukin 4 in T cells and inhibits lymphoid cell procoagulant activity Proceedings of the National Academy of Sciences of the United States of America 1997 94:11484-11489 DOI:10.1073/pnas.94.21.11484 PMID:9326636
- Fernandez, J. A., Petaja, J., Gruber, A., Griffin, J. H. Activated protein c correlates inversely with thrombin levels in resting healthy individuals American Journal of Hematology 1997 56:29-31 DOI:10.1002/(sici)1096-8652(199709)56:1<29::aid-ajh6>3.0.co;2-4 PMID:9298864
- Fernandez, J. A., Hackeng, T. M., Kojima, K., Griffin, J. H. The carbohydrate moiety of factor V modulates inactivation by activated protein C Blood 1997 89:4348-4354 PMID:9192757
- Petaja, J., Fernandez, J. A., Gruber, A., Griffin, J. H. Anticoagulant synergism of heparin and activated protein C in vitro - role of a novel anticoagulant mechanism of heparin, enhancement of inactivation of factor V by activated protein C Journal of Clinical Investigation 1997 99:2655-2663 DOI:10.1172/jci119454 PMID:9169495
- Tcheng, J. E., Lincoff, A. M., Sigmon, K. N., Lee, K. L., Kitt, M. M., Califf, R. M., Topol, E. J., Juran, N., Worley, S., Tuzi, J., Hollywood, L., Kleiman, N. S., et al. Randomised placebo-controlled trial of effect of eptifibatide on complications of percutaneous coronary intervention: IMPACT II Lancet 1997 349:1422-1428 PMID:9164315
- Fernandez, J. A., Heeb, M. J., Radtke, K. P., Griffin, J. H. Potent blood coagulant activity of human semen due to prostasome-bound tissue factor Biology of Reproduction 1997 56:757-763 DOI:10.1095/biolreprod56.3.757 PMID:9047022
- Zivelin, A., Griffin, J. H., Xu, X., Pabinger, I., Samama, M., Conard, J., Brenner, B., Eldor, A., Seligsohn, U. A single genetic origin for a common caucasian risk factor for venous thrombosis Blood 1997 89:397-402 PMID:9002940
- Gale, A. J., Sun, X., Heeb, M. J., Griffin, J. H. Nonenzymatic anticoagulant activity of the mutant serine protease Ser360Ala-activated protein C mediated by factor Va Protein Science 1997 6:132-140 DOI:PMC2143509 PMID:9007985
- Hackeng, T. M., Mounier, C. M., Bon, C., Dawson, P. E., Griffin, J. H., Kent, S. B. H. Total chemical synthesis of enzymatically active human type II secretory phospholipase A2 Proceedings of the National Academy of Sciences of the United States of America 1997 94:7845-7850 DOI:10.1073/pnas.94.15.7845 PMID:9223275 PMCID:PMC21517
- Macko, R. F., Ameriso, S. F., Gruber, A., Griffin, J. H., Fernandez, J. A., Barndt, R., Quismorio, F. P., Weiner, J. M., Fisher, M. Impairments of the protein C system and fibrinolysis in infection-associated stroke Stroke 1996 27:2005-2011 PMID:8898806
- Petaja, J., Lundstrom, U., Sairanen, H., Marttinen, E., Griffin, J. H. Central venous thrombosis after cardiac operations in children Journal of Thoracic and Cardiovascular Surgery 1996 112:883-889 DOI:10.1016/s0022-5223(96)70087-9 PMID:8873713
- Heeb, M. J., Kojima, Y., Hackeng, T. M., Griffin, J. H. Binding sites for blood coagulation factor Xa and protein S involving residues 493-506 in factor Va Protein Science 1996 5:1883-1889 DOI:10.1002/pro.5560050914 PMID:8880912 PMCID:PMC2143529
- Brenner, B., Zivelin, A., Lanir, N., Greengard, J. S., Griffin, J. H., Seligsohn, U. Venous thromboembolism associated with double heterozygosity for R506Q mutation of factor V and for T298M mutation of protein C in a large family of a previously described homozygous protein C-deficient newborn with massive thrombosis Blood 1996 88:877-880 PMID:8704244
- Fisher, M., Fernandez, J. A., Ameriso, S. F., Xie, D. C., Gruber, A., PaganiniHill, A., Griffin, J. H. Activated protein C resistance in ischemic stroke not due to factor V arginine(506)->glutamine mutation Stroke 1996 27:1163-1166 PMID:8685921
- Espana, F., SanchezCuenca, J., Estelles, A., Gilabert, J., Griffin, J. H., Heeb, M. J. Quantitative immunoassay for complexes of prostate-specific antigen with alpha(2)-macroglobulin Clinical Chemistry 1996 42:545-550 PMID:8605671
- Gillespie, D. L., Carringion, L. R., Griffin, J. H., Alving, B. M. Resistance to activated protein C: A common inherited cause of venous thrombosis Annals of Vascular Surgery 1996 10:174-177 DOI:10.1007/bf02000762 PMID:8733870
- Sifontes, M. T., Nuss, R., Jacobson, L. J., Griffin, J. H., MancoJohnson, M. J. Thrombosis in otherwise well children with the factor V leiden mutation Journal of Pediatrics 1996 128:324-328 DOI:10.1016/s0022-3476(96)70275-5 PMID:8774498
- Radtke, K. P., Greengard, J. S., Fernandez, J. A., Villoutreix, B. O., Griffin, J. H. A two-allele polymorphism in protein C inhibitor with varying frequencies in different ethnic populations Thrombosis and Haemostasis 1996 75:62-69 PMID:8713781
- Alving, B. M., Griffin, J. H. Laboratory evaluation and management of patients with venous thrombosis Consultant 1996 35:64-71
- Greengard, J. S., Xu, X., Gandrille, S., Griffin, J. H. Alternative PCR method for diagnosis of mutation causing activated protein-C resistant Gln(506)-factor-V Thrombosis Research 1995 80:441-443 DOI:10.1016/0049-3848(95)00197-y PMID:8588206
- Villoutreix, B. O., Fernandez, J. A., Teleman, O., Griffin, J. H. Comparative modeling of the three CP modules of the beta-chain of C4BP and evaluation of potential sites of interaction with protein S Protein Engineering 1995 8:1253-1258 DOI:10.1093/protein/8.12.1253 PMID:8869637
- Griffin, J. H. Blood coagulation. The thrombin paradox Nature 1995 378:337-338 DOI:10.1038/378337a0 PMID:7477366
- Heeb, M. J., Espana, F., Gittes, R. F., Griffin, J. H. Prostate specific antigen-alpha(2)-macroglobulin complexes in prostate cancer patient sera Biochemistry and Molecular Biology International 1995 37:917-923 PMID:8624498
- Spek, C. A., Greengard, J. S., Griffin, J. H., Bertina, R. M., Reitsma, P. H. Two mutations in the promoter region of the human protein-C gene both cause type-I protein-C deficiency by disruption of 2 HNF-3 binding-sites Journal of Biological Chemistry 1995 270:24216-24221 PMID:7592627
- Radtke, K. P., Fernandez, J. A., Villoutreix, B. O., Greengard, J. S., Griffin, J. H. Characterization of a cDNA for rhesus-monkey protein-C inhibitor - evidence for N-terminal involvement in heparin stimulation Thrombosis and Haemostasis 1995 74:1079-1087 PMID:8560417
- Gandrille, S., Greengard, J. S., Alhencgelas, M., Juhanvague, I., Abgrall, J. F., Jude, B., Griffin, J. H., Aiach, M. Incidence of activated protein-C resistance caused by the ARG-506 GLN mutation in factor-V in 113 unrelated symptomatic protein C-deficient patients Blood 1995 86:219-224 PMID:7795227
- Heeb, M. J., Kojima, Y., Greengard, J. S., Griffin, J. H. Activated protein C resistance: molecular mechanisms based on studies using purified Gln506-factor V Blood 1995 85:3405-3411 PMID:7780127
- Le, D. T., Griffin, J. H., Greengard, J. S., Mujumdar, V., Rapaport, S. I. Use of a generally applicable tissue factor-dependent factor-v assay to detect activated protein c-resistant factor va in patients receiving warfarin and in patients with a lupus anticoagulant Blood 1995 85:1704-1711 PMID:7703480
- Greengard, J. S., Fernandez, J. A., Radtke, K. P., Griffin, J. H. Identification of candidate residues for interaction of protein-S with C4b binding-protein and activated protein-C Biochemical Journal 1995 305:397-403 PMID:7832752 PMCID:PMC1136375
- Griffin, J. H., Heeb, M. J., Kojima, Y., Fernandez, J. A., Kojima, K., Hackeng, T. M., Greengard, J. S. Activated protein C resistance: molecular mechanisms Thrombosis and Haemostasis 1995 74:444-448 PMID:8578503
- Calkins, T., Greengard, J., Griffin, J. H., Bylund, D. Anticoagulant response to activated protein-C- method validation and assay comparison Journal of Clinical Laboratory Analysis 1995 9:418-423 DOI:10.1002/jcla.1860090614 PMID:8587012
- Greengard, J. S., Eichinger, S., Griffin, J. H., Bauer, K. A. Variability of thrombosis among homozygous siblings with resistance to activated protein-C due to an Arg- Gln mutation in the gene for factor-V New England Journal of Medicine 1994 331:1559-1562 DOI:10.1056/nejm199412083312305 PMID:7969326
- Greengard, J. S., Griffin, J. H., Fisher, C. L. Possible structural implications of 20 mutations in the protein-C protease domain Thrombosis and Haemostasis 1994 72:869-873 PMID:7740456
- Villoutreix, B. O., Getzoff, E. D., Griffin, J. H. A structural model for the prostate disease marker, human prostate-specific antigen Protein Science 1994 3:2033-2044 DOI:10.1002/pro.5560031116 PMID:7535613 PMCID:PMC2142655
- Radtke, K. P., Fernandez, J. A., Greengard, J. S., Tang, W. W., Wilson, C. B., Loskutoff, D. J., Scharrer, I., Griffin, J. H. Protein C inhibitor is expressed in tubular cells of human kidney Journal of Clinical Investigation 1994 94:2117-2124 DOI:10.1172/jci117566 PMID:7525654 PMCID:PMC294656
- Fernandez, J. A., Villoutreix, B. O., Hackeng, T. M., Griffin, J. H., Bouma, B. N. Analysis of protein-S C4b-binding protein interactions by homology modeling and inhibitory antibodies Biochemistry 1994 33:11073-11078 DOI:10.1021/bi00203a003 PMID:7727359
- Tsay, W., Greengard, J. S., Griffin, J. H. Exonic polymorphisms in the protein-C gene - interethnic comparison between caucasians and asians Human Genetics 1994 94:177-178 PMID:8045564
- Sun, X., Evatt, B., Griffin, J. H. Blood-coagulation factor Va abnormality associated with resistance to activated protein-C in venous thrombophilia Blood 1994 83:3120-3125 PMID:8193349
- Greengard, J. S., Sun, X., Xu, X., Fernandez, J. A., Griffin, J. H., Evatt, B. Activated protein C resistance caused by Arg506Gln mutation in factor Va Lancet 1994 343:1361-1362 DOI:10.1016/s0140-6736(94)92497-x PMID:7910348
- Gruber, A., Mori, E., del Zoppo, G. J., Waxman, L., Griffin, J. H. Alteration of fibrin network by activated protein-C Blood 1994 83:2541-2548 PMID:8167339
- Fisher, C. L., Greengard, J. S., Griffin, J. H. Models of the serine-protease domain of the human antithrombotic plasma factor-activated protein-C and its zymogen Protein Science 1994 3:588-599 DOI:10.1002/pro.5560030407 PMID:8003977 PMCID:PMC2142866
- Greengard, J. S., Fisher, C. L., Villoutreix, B., Griffin, J. H. Structural basis for type-I and type-II deficiencies of antithrombotic plasma protein-C - patterns revealed by 3-dimensional molecular modeling of mutations of the protease domain Proteins-Structure Function and Genetics 1994 18:367-380 DOI:10.1002/prot.340180407 PMID:8208728
- Heeb, M. J., Rosing, J., Bakker, H. M., Fernandez, J. A., Tans, G., Griffin, J. H. Protein-S binds to and inhibits factor-Xa Proceedings of the National Academy of Sciences of the United States of America 1994 91:2728-2732 DOI:10.1073/pnas.91.7.2728 PMID:8146182
- Fernandez, J. A., Griffin, J. H. A protein-S binding-site on C4b-binding protein involves beta-chain residues 31-45 Journal of Biological Chemistry 1994 269:2535-2540 PMID:8300581
- Espana, F., Estelles, A., Fernandez, P. J., Gilabert, J., Sanchezcuenca, J., Griffin, J. H. Evidence for the regulation of urokinase and tissue-type plasminogen activators by the serpin, protein-C inhibitor, in semen and blood-plasma Thrombosis and Haemostasis 1993 70:989-994 PMID:8165623
- Mesters, R. M., Heeb, M. J., Griffin, J. H. A novel exosite in the light chain of human activated protein C essential for interaction with blood coagulation factor Va Biochemistry 1993 32:12656-12663 DOI:10.1021/bi00210a014 PMID:8251484
- Gruber, A., Pal, A., Kiss, R. G., Sas, G., Griffin, J. H. Generation of activated protein-C during thrombolysis Lancet 1993 342:1275-1276 DOI:10.1016/0140-6736(93)92364-y PMID:7901587
- Griffin, J. H., Evatt, B., Wideman, C., Fernandez, J. A. Anticoagulant protein-C pathway defective in majority of thrombophilic patients Blood 1993 82:1989-1993 PMID:8400251
- Hanson, S. R., Griffin, J. H., Harker, L. A., Kelly, A. B., Esmon, C. T., Gruber, A. Antithrombotic effects of thrombin-induced activation of endogenous protein-C in primates Journal of Clinical Investigation 1993 92:2003-2012 DOI:10.1172/jci116795 PMID:8408654
- Tsay, W., Greengard, J. S., Montgomery, R. R., McPherson, R. A., Fucci, J. C., Koerper, M. A., Coughlin, J., Griffin, J. H. Genetic mutations in ten unrelated american patients with symptomatic type-1 protein-C deficiency Blood Coagulation & Fibrinolysis 1993 4:791-796 DOI:10.1097/00001721-199304050-00017 PMID:8292730
- Mesters, R. M., Heeb, M. J., Griffin, J. H. Interactions and inhibition of blood-coagulation factor-Va involving residues 311-325 of activated protein-C Protein Science 1993 2:1482-1489 DOI:10.1002/pro.5560020912 PMID:8401232 PMCID:PMC2142455
- Conard, J., Bauer, K. A., Gruber, A., Griffin, J. H., Schwarz, H. P., Horellou, M. H., Samama, M. M., Rosenberg, R. D. Normalization of markers of coagulation activation with a purified protein-C concentrate in adults with homozygous protein-C deficiency Blood 1993 82:1159-1164 PMID:8353282
- Fernandez, J. A., Heeb, M. J., Griffin, J. H. Identification of residues 413-433 of plasma protein S as essential for binding to C4b-binding protein Journal of Biological Chemistry 1993 268:16788-16794 PMID:7688369
- Phillips, D. J., Greengard, J. S., Fernandez, J. A., Ribeiro, M., Evatt, B. L., Griffin, J. H., Hooper, W. C. Protein-S, an antithrombotic factor, is synthesized and released by neural tumor-cells Journal of Neurochemistry 1993 61:344-347 DOI:10.1111/j.1471-4159.1993.tb03574.x PMID:8515282
- Heeb, M. J., Mesters, R. M., Tans, G., Rosing, J., Griffin, J. H. Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C Journal of Biological Chemistry 1993 268:2872-2877 PMID:8428962
- Berrettini, M., Schleef, R. R., Heeb, M. J., Hopmeier, P., Griffin, J. H. Assembly and expression of an intrinsic factor-IX activator complex on the surface of cultured human endothelial-cells Journal of Biological Chemistry 1992 267:19833-19839 PMID:1400299
- Bakker, H. M., Tans, G., Janssenclaessen, T., Thomassen, Mclgd, Hemker, H. C., Griffin, J. H., Rosing, J. The effect of phospholipids, calcium-ions and protein-S on rate constants of human factor-Va inactivation by activated human protein-C European Journal of Biochemistry 1992 208:171-178 DOI:10.1111/j.1432-1033.1992.tb17171.x PMID:1387359
- Griffin, J. H., Gruber, A., Fernandez, J. A. Reevaluation of total, free, and bound protein-S and C4b-binding protein-levels in plasma anticoagulated with citrate or hirudin Blood 1992 79:3203-3211 PMID:1534488
- Gruber, A., Griffin, J. H. Direct detection of activated protein-C in blood from human-subjects Blood 1992 79:2340-2348 PMID:1571547
- Greengard, J. S., Griffin, J. H. High-molecular-weight kininogen receptor Methods in Enzymology 1992 215:369-382 PMID:1331710
- Mesters, R. M., Houghten, R. A., Griffin, J. H. Identification of a sequence of human activated protein-C (residues 390-404) essential for its anticoagulant activity Journal of Biological Chemistry 1991 266:24514-24519 PMID:1761551
- Gruber, A., Harker, L. A., Hanson, S. R., Kelly, A. B., Griffin, J. H. Antithrombotic effects of combining activated protein-C and urokinase in nonhuman-primates Circulation 1991 84:2454-2462 PMID:1835678
- Heeb, M. J., Gruber, A., Griffin, J. H. Identification of divalent metal ion-dependent inhibition of activated protein-C by alpha-2-macroglobulin and alpha-2-antiplasmin in blood and comparisons to inhibition of factor-Xa, thrombin, and plasmin Journal of Biological Chemistry 1991 266:17606-17612 PMID:1716632
- Vicente, V., Espana, F., Tabernero, D., Estelles, A., Aznar, J., Hendl, S., Griffin, J. H. Evidence of activation of the protein-c pathway during acute vascular damage induced by mediterranean spotted-fever Blood 1991 78:416-422 PMID:1648982
- Geiger, M., Priglinger, U., Griffin, J. H., Binder, B. R. Urinary protein-C inhibitor - glycosaminoglycans synthesized by the epithelial kidney-cell line TCL-598 enhance its interaction with urokinase Journal of Biological Chemistry 1991 266:11851-11857 PMID:1646816
- Tans, G., Rosing, J., Christella, M., Thomassen, L. G. D., Heeb, M. J., Zwaal, R. F. A., Griffin, J. H. Comparison of anticoagulant and procoagulant activities of stimulated platelets and platelet-derived microparticles Blood 1991 77:2641-2648 PMID:2043766
- Espana, F., Gilabert, J., Aznar, J., Estelles, A., Kobayashi, T., Griffin, J. H. Complexes of activated protein-C with alpha-1-antitrypsin in normal-pregnancy and in severe preeclampsia American Journal of Obstetrics and Gynecology 1991 164:1310-1316 PMID:1852102
- Espana, F., Estelles, A., Griffin, J. H., Aznar, J. Interaction of plasma kallikrein with protein-C inhibitor in purified mixtures and in plasma Thrombosis and Haemostasis 1991 65:46-51 PMID:1850876
- Hendl, S., Espana, F., Aznar, J., Estelles, A., Gilabert, J., Griffin, J. H. Immunoaffinity purification of protein C with a calcium-dependent monoclonal antibody Revista Iberoamericana de Trombosis y Hemostasia 1991 4:25-28
- Espana, F., Gruber, A., Heeb, M. J., Hanson, S. R., Harker, L. A., Griffin, J. H. In vivo and in vitro complexes of activated protein C with two inhibitors in baboons Blood 1991 77:1754-1760 PMID:1849759
- Kuhn, L. A., Griffin, J. H., Fisher, C. L., Greengard, J. S., Bouma, B. N., Espana, F., Tainer, J. A. Elucidating the structural chemistry of glycosaminoglycan recognition by protein-C inhibitor Proceedings of the National Academy of Sciences of the United States of America 1990 87:8506-8510 DOI:10.1073/pnas.87.21.8506 PMID:2172989
- Espana, F., Vicente, V., Tabernero, D., Scharrer, I., Griffin, J. H. Determination of plasma protein-C inhibitor and of 2 activated protein-C-inhibitor complexes in normals and in patients with intravascular coagulation and thrombotic disease Thrombosis Research 1990 59:593-608 DOI:10.1016/0049-3848(90)90418-c PMID:2173167
- Gruber, A., Hanson, S. R., Kelly, A. B., Yan, B. S., Bang, N., Griffin, J. H., Harker, L. A. Inhibition of thrombus formation by activated recombinant protein-C in a primate model of arterial thrombosis Circulation 1990 82:578-585 PMID:2372904
- Heeb, M. J., Bischoff, R., Courtney, M., Griffin, J. H. Inhibition of activated protein C by recombinant alpha 1-antitrypsin variants with substitution of arginine or leucine for methionine-358 Journal of Biological Chemistry 1990 265:2365-2369 PMID:2298753
- Espana, F., Estelles, A., Griffin, J. H., Aznar, J., Gilabert, J. Aprotinin (trasylol) is a competitive inhibitor of activated protein-C Thrombosis Research 1989 56:751-756 DOI:10.1016/0049-3848(89)90292-2 PMID:2483763
- Espana, F., Griffin, J. H. Determination of functional and antigenic protein-C inhibitor and its complexes with activated protein-C in plasma by ELISA's Thrombosis Research 1989 55:671-682 DOI:10.1016/0049-3848(89)90298-3 PMID:2551066
- Geiger, M., Huber, K., Wojta, J., Stingl, L., Espana, F., Griffin, J. H., Binder, B. R. Complex formation between urokinase and plasma protein C inhibitor in vitro and in vivo Blood 1989 74:722-728 PMID:2752144
- Espana, F., Berrettini, M., Griffin, J. H. Purification and characterization of plasma protein-c inhibitor Thrombosis Research 1989 55:369-384 DOI:10.1016/0049-3848(89)90069-8 PMID:2551064
- Berrettini, M., Schleef, R. R., Espana, F., Loskutoff, D. J., Griffin, J. H. Interaction of type 1 plasminogen activator inhibitor with the enzymes of the contact activation system Journal of Biological Chemistry 1989 264:11738-11743 PMID:2787318
- Gladson, C. L., Schleef, R. R., Binder, B. R., Loskutoff, D. J., Griffin, J. H. A comparison between activated protein C and des-1-41-light chain-activated protein C in reactions with type 1 plasminogen activator inhibitor Blood 1989 74:173-181 PMID:2787675
- Schwarz, H. P., Heeb, M. J., Lottenberg, R., Roberts, H., Griffin, J. H. Familial protein S deficiency with a variant protein S molecule in plasma and platelets Blood 1989 74:213-221 PMID:2526663
- Geiger, M., White, T. M., Griffin, J. H. Functional assays for protein-C activity and protein-C inhibitor activity in plasma Thrombosis and Haemostasis 1989 61:86-92 PMID:2546280
- Gruber, A., Griffin, J. H., Harker, L. A., Hanson, S. R. Inhibition of platelet-dependent thrombus formation by human activated protein-C in a primate model Blood 1989 73:639-642 PMID:2917194
- Heeb, M. J., Mosher, D., Griffin, J. H. Activation and complexation of protein C and cleavage and decrease of protein S in plasma of patients with intravascular coagulation Blood 1989 73:455-461 PMID:2521800
- Heeb, M. J., Espana, F., Griffin, J. H. Inhibition and complexation of activated protein C by two major inhibitors in plasma Blood 1989 73:446-454 PMID:2917184
- Heeb, M. J., Schwarz, H. P., White, T., Lammle, B., Berrettini, M., Griffin, J. H. Immunoblotting studies of the molecular forms of protein C in plasma Thrombosis Research 1988 52:33-43 DOI:10.1016/0049-3848(88)90038-2 PMID:3201394
- Heeb, M. J., Griffin, J. H. Physiologic inhibition of human activated protein-C by alpha-1-antitrypsin Journal of Biological Chemistry 1988 263:11613-11616 PMID:3261294
- Lammle, B., Zuraw, B. L., Heeb, M. J., Schwarz, H. P., Berrettini, M., Curd, J. G., Griffin, J. H. Detection and quantitation of cleaved and uncleaved high molecular weight kininogen in plasma by ligand blotting with radiolabeled plasma prekallikrein or factor XI Thrombosis and Haemostasis 1988 59:151-161 PMID:3388291
- Geiger, M., Heeb, M. J., Binder, B. R., Griffin, J. H. Competition of activated protein-C and urokinase for a heparin-dependent inhibitor FASEB Journal 1988 2:2263-2267 PMID:3350241
- Schwarz, H. P., Muntean, W., Watzke, H., Richter, B., Griffin, J. H. Low total protein-S antigen but high protein-S activity due to decreased C4b-binding protein in neonates Blood 1988 71:562-565 PMID:2964259
- Alter, S. C., Lammle, B., Griffin, J. H., Schwartz, L. B. Tryptase from human mast-cells does not activate purified human Hageman-factor Clinical Allergy 1988 18:151-156 DOI:10.1111/j.1365-2222.1988.tb02854.x PMID:3284668
- Gladson, C. L., Scharrer, I., Hach, V., Beck, K. H., Griffin, J. H. The frequency of type-I heterozygous protein-S and protein-C deficiency in 141 unrelated young-patients with venous thrombosis Thrombosis and Haemostasis 1988 59:18-22 PMID:2966450
- Sakata, Y., Griffin, J. H., Loskutoff, D. J. Effect of activated protein C on the fibrinolytic components released by cultured bovine aortic endothelial cells Fibrinolysis 1988 2:7-15 DOI:10.1016/0268-9499(88)90059-8
- Tans, G., Verkleij, A. J., Yu, J., Griffin, J. H. Sulfatide bilayers as a surface for contact activation in human plasma Biochemical and Biophysical Research Communications 1987 149:1002-1007 DOI:10.1016/0006-291x(87)90508-0 PMID:3426605
- Gladson, C. L., Groncy, P., Griffin, J. H. Coumarin necrosis, neonatal purpura fulminans, and protein C deficiency Archives of Dermatology 1987 123:1701a-1706a PMID:2961308
- Heeb, M. J., Espana, F., Geiger, M., Collen, D., Stump, D. C., Griffin, J. H. Immunological identity of heparin-dependent plasma and urinary protein C inhibitor and plasminogen activator inhibitor-3 Journal of Biological Chemistry 1987 262:15813-15816 PMID:2824468
- Tans, G., Rosing, J., Berrettini, M., Lammle, B., Griffin, J. H. Autoactivation of human-plasma prekallikrein Journal of Biological Chemistry 1987 262:11308-11314 PMID:2440889
- Tans, G., Janssenclaessen, T., Rosing, J., Griffin, J. H. Studies on the effect of serine protease inhibitors on activated contact factors - application in amidolytic assays for factor-XIIa, plasma kallikrein and factor-XIa European Journal of Biochemistry 1987 164:637-642 DOI:10.1111/j.1432-1033.1987.tb11174.x PMID:3552674
- Schwarz, H. P., Schernthaner, G., Griffin, J. H. Decreased plasma levels of protein S in well-controlled type I diabetes mellitus Thrombosis and Haemostasis 1987 57:240 PMID:2955541
- Lammle, B., Berrettini, M., Griffin, J. H. Immunoblotting studies of coagulation factor-XII, plasma prekallikrein, and high-molecular-weight kininogen Seminars in Thrombosis and Hemostasis 1987 13:106-114 DOI:10.1055/s-2007-1003480 PMID:3494310
- Griffin, J. H., Heeb, M. J., Schwarz, H. P. Plasma protein S deficiency and thromboembolic disease Progress in Hematology 1987 15:39-49 PMID:2971986
- Schwarz, H. P., Heeb, M. J., Lammle, B., Berrettini, M., Griffin, J. H. Quantitative immunoblotting of plasma and platelet protein S Thrombosis and Haemostasis 1986 56:382-386 PMID:2436335
- Sakata, Y., Loskutoff, D. J., Gladson, C. L., Hekman, C. M., Griffin, J. H. Mechanism of protein C-dependent clot lysis: role of plasminogen activator inhibitor Blood 1986 68:1218-1223 PMID:3096399
- Cembrowski, G. S., Griffin, J. H., Mosher, D. F. Diagnostic efficacy of 6 plasma-proteins in evaluating consumptive coagulopathies - use of receiver operating characteristic curves to compare antithrombin-III, plasminogen, alpha-2-plasmin inhibitor, fibronectin, prothrombin, and protein-C Archives of Internal Medicine 1986 146:1997-2002 DOI:10.1001/archinte.146.10.1997 PMID:3767544
- Berrettini, M., Lammle, B., White, T., Heeb, M. J., Schwarz, H. P., Zuraw, B., Curd, J., Griffin, J. H. Detection of in vitro and in vivo cleavage of high molecular weight kininogen in human plasma by immunoblotting with monoclonal antibodies Blood 1986 68:455-462 PMID:3730610
- Greengard, J. S., Heeb, M. J., Ersdal, E., Walsh, P. N., Griffin, J. H. Binding of coagulation factor-XI to washed human-platelets Biochemistry 1986 25:3884-3890 DOI:10.1021/bi00361a022 PMID:3017409
- Bouma, B. N., Kerbiriou, D. M., Baker, J., Griffin, J. H. Characterization of a variant prekallikrein, prekallikrein Long-Beach, from a family with mixed cross-reacting material positive and cross-reacting material negative prekallikrein deficiency Journal of Clinical Investigation 1986 78:170-176 DOI:10.1172/jci112547 PMID:3487556
- Lammle, B., Berrettini, M., Griffin, J. H. Enhanced specificity of immunoblotting using radiolabeled antigen overlay - studies of blood-coagulation factor-XII and prekallikrein in plasma Analytical Biochemistry 1986 156:118-125 DOI:10.1016/0003-2697(86)90162-4 PMID:3638135
- Podack, E. R., Dahlback, B., Griffin, J. H. Interaction of S-protein of complement with thrombin and antithrombin-III during coagulation - protection of thrombin by S-protein from antithrombin-III inactivation Journal of Biological Chemistry 1986 261:7387-7392 PMID:3754869
- Bezeaud, A., Drouet, L., Leverger, G., Griffin, J. H., Guillin, M. C. Effect of L-asparaginase therapy for acute lymphoblastic-leukemia on plasma vitamin-K-dependent coagulation-factors and inhibitors Journal of Pediatrics 1986 108:698-701 DOI:10.1016/s0022-3476(86)81044-7 PMID:2939229
- Lammle, B., Berrettini, M., Schwarz, H. P., Heeb, M. J., Griffin, J. H. Quantitative immunoblotting assay of blood-coagulation factor-XII Thrombosis Research 1986 41:747-759 DOI:10.1016/0049-3848(86)90373-7 PMID:3085274
- Sas, G., Blasko, G., Petro, I., Griffin, J. H. A protein S deficient family with portal vein thrombosis Thrombosis and Haemostasis 1985 54:724 PMID:2935967
- Sakata, Y., Curriden, S., Lawrence, D., Griffin, J. H., Loskutoff, D. J. Activated protein C stimulates the fibrinolytic activity of cultured endothelial cells and decreases antiactivator activity Proceedings of the National Academy of Sciences of the United States of America 1985 82:1121-1125 DOI:10.1073/pnas.82.4.1121 PMID:3871946 PMCID:PMC397206
- Lammle, B., Griffin, J. H. Formation of the fibrin clot: the balance of procoagulant and inhibitory factors Clinics in Haematology 1985 14:281-342 PMID:2994929
- Schwarz, H. P., Heeb, M. J., Wenceldrake, J. D., Griffin, J. H. Identification and quantitation of protein-S in human-platelets Blood 1985 66:1452-1455 PMID:2933098
- Cosio, F. G., Harker, C., Batard, M. A., Brandt, J. T., Griffin, J. H. Plasma-concentrations of the natural anticoagulants protein-C and protein-S in patients with proteinuria Journal of Laboratory and Clinical Medicine 1985 106:218-222 PMID:3160800
- Bock, P. E., Shore, J. D., Tans, G., Griffin, J. H. Protein-protein interactions in contact activation of blood-coagulation - binding of high molecular-weight kininogen and the 5-(iodoacetamido)fluorescein-labeled kininogen light chain to prekallikrein, kallikrein, and the separated kallikrein heavy and light-chains Journal of Biological Chemistry 1985 260:2434-2443
- Rosing, J., Tans, G., Griffin, J. H. Surface-dependent activation of human factor-XII (Hageman-factor) by kallikrein and its light chain European Journal of Biochemistry 1985 151:531-538 DOI:10.1111/j.1432-1033.1985.tb09135.x PMID:3875484
- Schwartz, L. B., Bradford, T., Griffin, J. H. The effect of tryptase from human mast-cells on human prekallikrein Biochemical and Biophysical Research Communications 1985 129:76-81 DOI:10.1016/0006-291x(85)91405-6 PMID:3890857
- Griffin, J. H. Clinical-studies of protein-C Seminars in Thrombosis and Hemostasis 1984 10:162-166 DOI:10.1055/s-2007-1004419 PMID:6377499
- Schwarz, H. P., Fischer, M., Hopmeier, P., Batard, M. A., Griffin, J. H. Plasma protein-S deficiency in familial thrombotic disease Blood 1984 64:1297-1300 PMID:6238642
- Fulcher, C. A., Gardiner, J. E., Griffin, J. H., Zimmerman, T. S. Proteolytic inactivation of human factor-VIII procoagulant protein by activated human protein-C and its analogy with factor-V Blood 1984 63:486-489 PMID:6419799
- Greengard, J. S., Griffin, J. H. Receptors for high molecular-weight kininogen on stimulated washed human-platelets Biochemistry 1984 23:6863-6869 DOI:10.1021/bi00321a090 PMID:6099145
- Griffin, J. H., Bezeaud, A., Evatt, B., Mosher, D. Studies of protein-C in thromboembolic disease Ricerca in Clinica e in Laboratorio 1984 14:469-473 PMID:6395293
- Gardiner, J. E., Griffin, J. H. Studies on human protein-C inhibitor in normal and factor-V/VIII deficient plasmas Thrombosis Research 1984 36:197-203 DOI:10.1016/0049-3848(84)90219-6 PMID:6549082
- Walsh, P. N., Tuszynski, G. P., Greengard, J. S., Griffin, J. H. The possible role of platelets in bypassing the contact phase of blood coagulation Haematologia 1984 17:169-178 PMID:6534825
- Miles, L. A., Greengard, J. S., Griffin, J. H. A comparison of the abilities of plasma kallikrein, beta-Factor XIIa, Factor XIa and urokinase to activate plasminogen Thrombosis Research 1983 29:407-417 DOI:10.1016/0049-3848(83)90244-x PMID:6344314
- Miles, L. A., Rothschild, Z., Griffin, J. H. Dextran sulfate-dependent fibrinolysis in whole human plasma. Journal of Laboratory and Clinical Medicine 1983 101:214-225 PMID:6185600
- Miles, L. A., Rothschild, Z., Griffin, J. H. Dextran sulfate-dependent fibrinolytic activity in whole human plasma Progress in Fibrinolysis 1983 6:58-61
- Gardiner, J. E., Griffin, J. H. Human protein-C and thromboembolic disease Progress in Hematology 1983 13:265-278 PMID:6422505
- Bouma, B. N., Vlooswijk, R. A. A., Griffin, J. H. Immunological studies of human coagulation factor-XI and its complex with high molecular-weight kininogen Blood 1983 62:1123-1131 PMID:6626744
- Branson, H. E., Marble, R., Katz, J., Griffin, J. H. Inherited protein-C deficiency and coumarin-responsive chronic relapsing purpura fulminans in a newborn-infant Lancet 1983 2:1165-1168 PMID:6139528
- Vandergraaf, F., Koedam, J. A., Griffin, J. H., Bouma, B. N. Interaction of human-plasma kallikrein and its light chain with C1 inhibitor Biochemistry 1983 22:4860-4866 DOI:10.1021/bi00289a037 PMID:6556071
- Vandergraaf, F., Greengard, J. S., Bouma, B. N., Kerbiriou, D. M., Griffin, J. H. Isolation and functional-characterization of the active light chain of activated human-blood coagulation factor-XI Journal of Biological Chemistry 1983 258:9669-9675 PMID:6604052
- Tans, G., Rosing, J., Griffin, J. H. Sulfatide-dependent autoactivation of human-blood coagulation Factor-XII (Hageman-factor) Journal of Biological Chemistry 1983 258:8215-8222 PMID:6553053
- Miles, L. A., Plow, E. F., Donnelly, K. J., Hougie, C., Griffin, J. H. A bleeding disorder due to deficiency of alpha-2-antiplasmin Blood 1982 59:1246-1251 PMID:7082827
- Marlar, R. A., Kleiss, A. J., Griffin, J. H. An alternative extrinsic pathway of human-blood coagulation Blood 1982 60:1353-1358 PMID:7139124
- Vandergraaf, F., Tans, G., Bouma, B. N., Griffin, J. H. Isolation and functional-properties of the heavy and light-chains of human-plasma kallikrein Journal of Biological Chemistry 1982 257:4300-4305 PMID:6815193
- Marlar, R. A., Kleiss, A. J., Griffin, J. H. Mechanism of action of human activated protein-C, a thrombin-dependent anticoagulant enzyme Blood 1982 59:1067-1072 PMID:6803853
- Tans, G., Griffin, J. H. Properties of sulfatides in factor-XII-dependent contact activation Blood 1982 59:69-75 PMID:6914902
- Griffin, J. H., Mosher, D. F., Zimmerman, T. S., Kleiss, A. J. Protein-C, an antithrombotic protein, is reduced in hospitalized-patients with intravascular coagulation Blood 1982 60:261-264 PMID:6896290
- Cochrane, C. G., Griffin, J. H. The biochemistry and pathophysiology of the contact system of plasma Advances in Immunology 1982 33:241-306 DOI:10.1016/s0065-2776(08)60837-8 PMID:6182767
- Walsh, P. N., Griffin, J. H. Contributions of human-platelets to the proteolytic activation of blood-coagulation factor-XII and factor-XI Blood 1981 57:106-118 PMID:7004531
- Griffin, J. H., Evatt, B., Zimmerman, T. S., Kleiss, A. J., Wideman, C. Deficiency of protein-C in congenital thrombotic disease Journal of Clinical Investigation 1981 68:1370-1373 DOI:10.1172/jci110385 PMID:6895379
- Miles, L. A., Burnier, J. P., Verlander, M. S., Goodman, M., Kleiss, A. J., Griffin, J. H. Inactivation of purified human alpha 2-antiplasmin and purified human C1 inhibitor by synthetic fibrinolytic agents Blood 1981 57:1015-1024 PMID:6452920
- Curd, J. G., Yelvington, M., Ziccardi, R. J., Mathison, D. A., Griffin, J. H. Purification and characterization of 2 functionally distinct forms of C-1 inhibitor from a patient with angioedema Clinical and Experimental Immunology 1981 45:261-270 PMID:6976242 PMCID:PMC1537389
- Wiggins, R. C., Loskutoff, D. J., Cochrane, C. G., Griffin, J. H., Edgington, T. S. Activation of rabbit Hageman factor by homogenates of cultured rabbit endothelial cells Journal of Clinical Investigation 1980 65:197-206 DOI:10.1172/jci109651 PMID:6444222 PMCID:PMC371355
- Marlar, R. A., Griffin, J. H. Deficiency of protein-C inhibitor in combined factor-V-VIII deficiency disease Journal of Clinical Investigation 1980 66:1186-1189 DOI:10.1172/jci109952 PMID:6253526
- Bouma, B. N., Miles, L. A., Beretta, G., Griffin, J. H. Human plasma prekallikrein. Studies of its activation by activated factor XII and of its inactivation by diisopropyl phosphofluoridate Biochemistry 1980 19:1151-1160 DOI:10.1021/bi00547a018 PMID:6768384
- Kerbiriou, D. M., Bouma, B. N., Griffin, J. H. Immunochemical studies of human high molecular-weight kininogen and of its complexes with plasma prekallikrein or kallikrein Journal of Biological Chemistry 1980 255:3952-3958 PMID:6154706
- Bouma, B. N., Kerbiriou, D. M., Vlooswijk, R. A. A., Griffin, J. H. Immunological studies of prekallikrein, kallikrein, and high-molecular-weight kininogen in normal and deficient plasmas and in normal plasma after cold-dependent activation Journal of Laboratory and Clinical Medicine 1980 96:693-709 PMID:6903191
- Ginsberg, M. H., Jaques, B., Cochrane, C. G., Griffin, J. H. Urate crystal--dependent cleavage of Hageman factor in human plasma and synovial fluid Journal of Laboratory and Clinical Medicine 1980 95:497-506 PMID:6898641
- Seligsohn, U., Osterud, B., Brown, S. F., Griffin, J. H., Rapaport, S. I. Activation of human factor-VII in plasma and in purified systems - roles of activated factor-IX, kallikrein, and activated factor-XII Journal of Clinical Investigation 1979 64:1056-1065 DOI:10.1172/jci109543 PMID:479368
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Kerbiriou, D. M., Griffin, J. H.
Human high molecular-weight kininogen - studies of structure-function-relationships and of proteolysis of the molecule occurring during contact activation of plasma
Journal of Biological Chemistry
1979
254:2020-2027
PMID:500690
- Cochrane, C. G., Griffin, J. H. Molecular assembly in the contact phase of the Hageman factor system American Journal of Medicine 1979 67:657-664 DOI:10.1016/0002-9343(79)90253-5 PMID:386794
- Wiggins, R. C., Cochrane, C. G., Griffin, J. H. Rabbit blood coagulation factor XI. Mechanism of activation of rabbit Hageman factor (factor XII) Thrombosis Research 1979 15:487-495 DOI:10.1016/0049-3848(79)90154-3 PMID:494157
- Wiggins, R. C., Cochrane, C. G., Griffin, J. H. Rabbit blood coagulation factor XI. Purification and properties Thrombosis Research 1979 15:475-486 DOI:10.1016/0049-3848(79)90153-1 PMID:494156
- Griffin, J. H., Cochrane, C. G. Recent advances in the understanding of contact activation reactions Seminars in Thrombosis and Hemostasis 1979 5:254-273 PMID:386517
- Cochrane, C. G., Revak, S. D., Wiggins, R. C., Griffin, J. H. The Hageman Factor system in inflammation Advances in Inflammation Research 1979 1:249-261
- Davis, S., Furie, B. C., Griffin, J. H., Furie, B. Circulating inhibitors of blood-coagulation associated with procainamide-induced lupus-erythematosus American Journal of Hematology 1978 4:401-407 DOI:10.1002/ajh.2830040411 PMID:717399
- Bouma, B. N., Griffin, J. H. Deficiency of factor-XII-dependent plasminogen proactivator in prekallikrein-deficient plasma Journal of Laboratory and Clinical Medicine 1978 91:148-155 PMID:73563
- Seligsohn, U., Osterud, B., Griffin, J. H., Rapaport, S. I. Evidence for the participation of both activated factor-XII and activated factor-IX in cold-promoted activation of factor-VII Thrombosis Research 1978 13:1049-1056 DOI:10.1016/0049-3848(78)90233-5 PMID:749262
- Osterud, B., Bouma, B. N., Griffin, J. H. Human-blood coagulation factor-IX - purification, properties, and mechanism of activation by activated factor-XI Journal of Biological Chemistry 1978 253:5946-5951 PMID:681330
- Griffin, J. H. Role of surface in surface-dependent activation of Hageman-factor (blood-coagulation factor-XII) Proceedings of the National Academy of Sciences of the United States of America 1978 75:1998-2002 DOI:10.1073/pnas.75.4.1998 PMID:273926
- Revak, S. D., Cochrane, C. G., Bouma, B. N., Griffin, J. H. Surface and fluid phase activities of two forms of activated Hageman factor produced during contact activation of plasma Journal of Experimental Medicine 1978 147:719-729 DOI:10.1084/jem.147.3.719 PMID:632748 PMCID:PMC2184209
- Kerbiriou, D., Herve, G., Griffin, J. H. Aspartate-transcarbamylase lacking catalytic subunit interactions - study of conformational-changes by uv absorbance and circular-dichroism spectroscopy Journal of Biological Chemistry 1977 252:2881-2890 PMID:323258
- Griffin, J. H., Dibello, C., Alazard, R., Nicolas, P., Cohen, P. Carbon-13 nuclear magnetic-resonance studies of binding of selectively 13C-enriched oxytocins to neurohypophyseal protein, bovine neurophysin-II Biochemistry 1977 16:4194-4198 DOI:10.1021/bi00638a010 PMID:561612
- Bouma, B. N., Griffin, J. H. Human blood coagulation factor-XI - purification, properties, and mechanism of activation by activated factor-XII Journal of Biological Chemistry 1977 252:6432-6437 PMID:893417
- Wiggins, R. C., Bouma, B. N., Cochrane, C. G., Griffin, J. H. Role of high-molecular-weight kininogen in surface-binding and activation of coagulation Factor XI and prekallikrein Proceedings of the National Academy of Sciences of the United States of America 1977 74:4636-4640 DOI:10.1073/pnas.74.10.4636 PMID:270705 PMCID:PMC432002
- Convert, O., Griffin, J. H., Dibello, C., Nicolas, P., Cohen, P. Selectively enriched 13C-labeled proline-7 and 13C-labeled leucine-8 ocytocins as probes for analysis of peptide hormone interactions with bovine neurophysin i using 13C nuclear magnetic-resonance spectroscopy Biochemistry 1977 16:5061-5065 DOI:10.1021/bi00642a018 PMID:562184
- Revak, S. D., Cochrane, C. G., Griffin, J. H. The binding and cleavage characteristics of human Hageman factor during contact activation. A comparison of normal plasma with plasmas deficient in factor XI, prekallikrein, or high molecular weight kininogen Journal of Clinical Investigation 1977 59:1167-1175 DOI:10.1172/jci108741 PMID:864009 PMCID:PMC372330
- Griffin, J. H., Cochrane, C. G. Human factor XII (Hageman factor) Methods in Enzymology 1976 45:56-65 DOI:10.1016/S0076-6879(76)45009-7 PMID:1012017
- Griffin, J. H., Cochrane, C. G. Mechanisms for the involvement of high molecular weight kininogen in surface-dependent reactions of Hageman factor Proceedings of the National Academy of Sciences of the United States of America 1976 73:2554-2558 DOI:10.1073/pnas.73.8.2554 PMID:1066663 PMCID:PMC430686
- Griffin, J. H., Furie, B., Schechter, A. N. Application of nuclear magnetic-resonance spectroscopy to proteins Biochimie 1975 57:453-460 DOI:10.1016/s0300-9084(75)80332-4 PMID:1148335
- Griffin, J. H., Alazard, R., Dibello, C., Sala, E., Mermetbouvier, R., Cohen, P. Carbon-13 nuclear magnetic-resonance studies on (85 percent 13C-enriched Gly9) oxytocin FEBS Letters 1975 50:168-171 DOI:10.1016/0014-5793(75)80481-9 PMID:1112410
- Griffin, J. H., Cohen, J. S., Cohen, P., Camier, M. Drug-biomolecule interactions - proton magnetic-resonance studies of complex-formation between bovine neurophysins and oxytocin at molecular level Journal of Pharmaceutical Sciences 1975 64:507-511 DOI:10.1002/jps.2600640341 PMID:239193
- Wolff, J., Alazard, R., Camier, M., Griffin, J. H., Cohen, P. Interactions of bovine neurophysins with neurohypophyseal hormones - role of tyrosine-49 Journal of Biological Chemistry 1975 250:5215-5220 PMID:1150656
- Cohen, P., Camier, M., Wolff, J., Alazard, R., Cohen, J. S., Griffin, J. H. Studies of bovine neurophysin-neurohypophyseal hormone interactions Annals of the New York Academy of Sciences 1975 248:463-479 DOI:10.1111/j.1749-6632.1975.tb34207.x PMID:235235
- Alazard, R., Cohen, P., Cohen, J. S., Griffin, J. H. Interactions of bovine neurophysin-II with oxytocin and 8-lysine vasopressin - high-resolution proton nuclear magnetic-resonance spectroscopy studies Journal of Biological Chemistry 1974 249:6895-6900 PMID:4423570
- Furie, B., Griffin, J. H., Feldmann, R. J., Sokoloski, E. A., Schechter, A. N. The active site of staphylococcal nuclease: paramagnetic relaxation of bound nucleotide inhibitor nuclei by lanthanide ions Proceedings of the National Academy of Sciences of the United States of America 1974 71:2833-2837 DOI:10.1073/pnas.71.7.2833 PMID:4528015 PMCID:PMC388566
- Rosenbusch, J. P., Griffin, J. H. Carbamyl phosphate binding to aspartate transcarbamylase. Partial saturation and its alteration by succinate Journal of Biological Chemistry 1973 248:5063-5066 PMID:4577764
- Griffin, J. H., Alazard, R., Cohen, P. Complex-formation between bovine neurophysin-I and oxytocin, vasopressin, and tripeptide analogs of their NH2-terminal region - absorbance and circular-dichroism difference spectroscopic studies Journal of Biological Chemistry 1973 248:7975-7978 PMID:4796247
- Griffin, J. H., Rosenbusch, J. P., Blout, E. R., Weber, K. K. Conformational changes in aspartate transcarbamylase. II. Circular dichroism evidence for the involvement of metal ions in allosteric interactions Journal of Biological Chemistry 1973 248:5057-5062 PMID:4577763
- Griffin, J. H., Schechter, A. N., Cohen, J. S. Nuclear magnetic resonance studies of a ribonuclease-dinucleoside phosphonate complex and their implications for the mechanism of the enzyme Annals of the New York Academy of Sciences 1973 222:693-708 DOI:10.1111/j.1749-6632.1973.tb15296.x PMID:4522440
- Cohen, J. S., Griffin, J. H., Schechter, A. N. Nuclear magnetic resonance titration curves of histidine ring protons. IV. The effects of phosphate and sulfate on ribonuclease Journal of Biological Chemistry 1973 248:4305-4310 PMID:4736427
- Griffin, J. H., Cohen, J. S., Schechter, A. N. The assignment of an exchangeable low-field NH proton resonance of ribonuclease A to the active-site histidine-119 Biochemistry 1973 12:2096-2099 DOI:10.1021/bi00735a012 PMID:4735881
- Griffin, J. H., Rosenbusch, J. P., Weber, K. K., Blout, E. R. Conformational changes in aspartate trancarbamylase. I. Studies of ligand binding and of subunit interactions by circular dichroism spectroscopy Journal of Biological Chemistry 1972 247:6482-6490 PMID:4561937
- Cohen, P., Griffin, J. H., Camier, M., Caizergues, M., Fromageot, P., Cohen, J. S. Hormonal interactions at the molecular level: A high resolution proton magnetic resonance study of bovine neurophysins and their interactions with oxytocin FEBS Letters 1972 25:282-286 DOI:10.1016/0014-5793(72)80504-0 PMID:11946770
- Griffin, J. H., Criddle, R. S. Substrate-inhibited lactate dehydrogenase. Reaction mechanism and essential role of dissociated subunits Biochemistry 1970 9:1195-1205 DOI:10.1021/bi00807a021 PMID:4313938