academic article

• Deguchi, H., Shukla, M., Hayat, M., Torkamani, A., Elias, D. J., Griffin, J. H. Novel exomic rare variants associated with venous thrombosis British Journal of Haematology  2020  DOI:10.1111/bjh.16613  PMID:32232851
• von Drygalski, A., Bhat, V., Gale, A. J., Averell, P. M., Cramer, T. J., Elias, D. J., Griffin, J. H., Mosnier, L. O. An engineered factor Va prevents bleeding induced by direct-acting oral anticoagulants by different mechanisms Blood Advances  2020 4:3716-3727  DOI:10.1182/bloodadvances.2020001699  PMID:32777068  PMCID:PMC7422119
• Heeb, M. J., Fernandez, J. A., Yamashita, A., McDowell, O. R., Guo, Z. H., Mosnier, L. O., Deguchi, H., Griffin, J. H. Activated protein C anticoagulant activity is enhanced by skeletal muscle myosin Haematologica  2020 105:E424-E427  DOI:10.3324/haematol.2019.242982  PMID:31857364  PMCID:PMC7395292
• Mukherjee, P., Lyden, P., Fernandez, J. A., Davis, T. P., Pryor, K. E., Zlokovic, B. V., Griffin, J. H. 3K3A-Activated Protein C Variant Does Not Interfere With the Plasma Clot Lysis Activity of Tenecteplase Stroke  2020 51:2236-2239  DOI:10.1161/strokeaha.120.028793  PMID:32568648  PMCID:PMC7380733
• Yamashita, A., Zhang, Y. Q., Sanner, M. F., Griffin, J. H., Mosnier, L. O. C-terminal residues of activated protein C light chain contribute to its anticoagulant and cytoprotective activities Journal of Thrombosis and Haemostasis  2020 18:1027-1038  DOI:10.1111/jth.14756  PMID:32017367
• Kondreddy, V., Pendurthi, U. R., Xu, X., Griffin, J. H., Rao, L. V. M. FVIIa (Factor VIIa) Induces Biased Cytoprotective Signaling in Mice Through the Cleavage of PAR (Protease-Activated Receptor)-1 at Canonical Arg41 (Arginine41) Site Arteriosclerosis Thrombosis and Vascular Biology  2020 40:1275-1288  DOI:10.1161/atvbaha.120.314244  PMID:32212848
• Deguchi, T. K., Deguchi, H., Guo, Z., Elias, D. J., Griffin, J. H. Plasma skeletal muscle myosin phenotypes identified by immunoblotting are associated with pulmonary embolism occurrence in young adults Thrombosis Research  2020 189:88-92  DOI:10.1016/j.thromres.2020.02.020  PMID:32192996
• Kant, R., Halder, S. K., Fernandez, J. A., Griffin, J. H., Milner, R. Activated Protein C Attenuates Experimental Autoimmune Encephalomyelitis Progression by Enhancing Vascular Integrity and Suppressing Microglial Activation Frontiers in Neuroscience  2020 14  DOI:10.3389/fnins.2020.00333  PMID:32351356  PMCID:PMC7174764
• Zilberman-Rudenko, J., Deguchi, H., Shukla, M., Oyama, Y., Orje, J. N., Guo, Z. H., Wyseure, T., Mosnier, L. O., McCarty, O. J. T., Ruggeri, Z. M., Eckle, T., Griffin, J. H. Cardiac Myosin Promotes Thrombin Generation and Coagulation In Vitro and In Vivo Arteriosclerosis Thrombosis and Vascular Biology  2020 40:901-913  DOI:10.1161/atvbaha.120.313990  PMID:32102568  PMCID:PMC7135739
• Coleman, J. R., Moore, E. E., Zilberman-Rudenko, J., Samuels, J. M., Cohen, M. J., Silliman, C. C., Banerjee, A., Sauaia, A., Griffin, J. H., Deguchi, H. Cardiac and skeletal muscle myosin exert procoagulant effects Shock  2019 52:554-555  DOI:10.1097/shk.0000000000001426  PMID:31613865
• Deguchi, H., Guo, Z., Hayat, M., Pflimlin, E., Lear, S., Shen, W., Griffin, J. H. Molecular interaction site on procoagulant myosin for factor Xa?dependent prothrombin activation Journal of Biological Chemistry  2019 294:15176-15181  DOI:10.1074/jbc.AC119.010236  PMID:31481465  PMCID:PMC6791324
• Muller-Calleja, N., Hollerbach, A., Ritter, S., Pedrosa, D. G., Strand, D., Graf, C., Reinhardt, C., Strand, S., Poncelet, P., Griffin, J. H., Lackner, K. J., Ruf, W. Tissue factor pathway inhibitor primes monocytes for antiphospholipid antibody-induced thrombosis Blood  2019 134:1119-1131  DOI:10.1182/blood.2019001530  PMID:31434703
• Sinha, R. K., Flynn, R., Zaiken, M., Paz, K., Gavin, A. L., Nemazee, D., Fernandez, J. A., Xu, X., Griffin, J. H., Blazar, B. R. Activated protein C ameliorates chronic graft-versus-host disease by PAR1-dependent biased cell signaling on T cells Blood  2019 134:776-781  DOI:10.1182/blood.2019001259  PMID:31243040  PMCID:PMC6716074
• Rajput, P. S., Lamb, J. A., Fernandez, J. A., Bai, J., Pereira, B. R., Lei, I. F., Leung, J., Griffin, J. H., Lyden, P. D. Neuroprotection and vasculoprotection using genetically targeted protease-ligands Brain Research  2019 1715:13-20  DOI:10.1016/j.brainres.2019.03.010  PMID:30880117  PMCID:PMC6500472
• Lazic, D., Sagare, A. P., Nikolakopoulou, A. M., Griffin, J. H., Vassar, R., Zlokovic, B. V. 3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice Journal of Experimental Medicine  2019 216:279-293  DOI:10.1084/jem.20181035  PMID:30647119  PMCID:PMC6363429
• Lyden, P., Pryor, K. E., Coffey, C. S., Cudkowicz, M., Conwit, R., Jadhav, A., Sawyer, R. N., Claassen, J., Adeoye, O., Song, S., Hannon, P., Rost, N. S., et al. Final Results of the RHAPSODY Trial: A Multi-center, phase 2 trial using a continual reassessment method to determine the safety and tolerability of 3K3A-APC, a recombinant variant of human activated protein C, in combination with tissue plasminogen activator, mechanical thrombectomy or both in moderate to severe acute ischemic stroke Annals of Neurology  2019 85:125-136  DOI:10.1002/ana.25383  PMID:30450637  PMCID:PMC6342508
• Mukherjee, P., Leman, L. J., Griffin, J. H., Ghadiri, M. R. Design of a DNA-programmed plasminogen activator Journal of the American Chemical Society  2018 140:15516-15524  DOI:10.1021/jacs.8b10166  PMID:30347143
• Griffin, J. H., Zlokovic, B. V., Mosnier, L. O. Activated protein C, protease activated receptor 1, and neuroprotection Blood  2018 132:159-169  DOI:10.1182/blood-2018-02-769026  PMID:29866816  PMCID:PMC6043978
• Healy, L. D., Rigg, R. A., Griffin, J. H., McCarty, O. J. T. Regulation of immune cell signaling by activated protein C Journal of Leukocyte Biology  2018 103:1197-1203  DOI:10.1002/jlb.3mir0817-338r  PMID:29601101
• Gupta, N., Liu, R., Shin, S., Sinha, R., Pogliano, J., Pogliano, K., Griffin, J. H., Nizet, V., Corriden, R. SCH79797 improves outcomes in experimental bacterial pneumonia by boosting neutrophil killing and direct antibiotic activity Journal of Antimicrobial Chemotherapy  2018 73:1586-1594  DOI:10.1093/jac/dky033  PMID:29514266  PMCID:PMC5961356
• Amar, A. P., Sagare, A. P., Zhao, Z., Wang, Y., Nelson, A. R., Griffin, J. H., Zlokovic, B. V. Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C Neuropharmacology  2018 134:293-301  DOI:10.1016/j.neuropharm.2017.09.021  PMID:28923278  PMCID:PMC5857404
• Gupta, N., Sinha, R., Krasnodembskaya, A., Xu, X., Nizet, V., Matthay, M. A., Griffin, J. H. The TLR4-PAR1 axis regulates bone marrow mesenchymal stromal cell survival and therapeutic capacity in experimental bacterial pneumonia Stem Cells  2018 36:796-806  DOI:10.1002/stem.2796  PMID:29396891  PMCID:PMC5918231
• Martos, L., Ramon, L. A., Oto, J., Fernandez-Pardo, A., Bonanad, S., Cid, A. R., Gruber, A., Griffin, J. H., Espana, F., Navarro, S., Medina, P. α2-macroglobulin is a significant in vivo inhibitor of activated protein C and low APC:α2M levels are associated with venous thromboembolism Thrombosis and Haemostasis  2018 118:630-638  DOI:10.1055/s-0038-1629902  PMID:29448296
• Prince, R., Bologna, L., Manetti, M., Melchiorre, D., Rosa, I., Dewarrat, N., Suardi, S., Amini, P., Fernandez, J. A., Burnier, L., Quarroz, C., Caro, M. D. R., et al. Targeting anticoagulant protein S to improve hemostasis in hemophilia Blood  2018 131:1360-1371  DOI:10.1182/blood-2017-09-800326  PMID:29317453  PMCID:PMC5865230
• Sinha, R. K., Wang, Y., Zhao, Z., Xu, X., Burnier, L., Gupta, N., Fernandez, J. A., Martin, G., Kupriyanov, S., Mosnier, L. O., Zlokovic, B. V., Griffin, J. H. PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke Blood  2018 131:1163-1171  DOI:10.1182/blood-2017-10-810895  PMID:29343482  PMCID:PMC5855020
• Nazir, S., Gadi, I., Al-Dabet, M. M., Elwakiel, A., Kohli, S., Ghosh, S., Manoharan, J., Ranjan, S., Bock, F., Braun-Dullaeus, R. C., Esmon, C. T., Huber, T. B., et al. Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition Blood  2017 130:2664-2677  DOI:10.1182/blood-2017-05-782102  PMID:28882883
• Fernandez, J. A., Xu, X., Sinha, R. K., Mosnier, L. O., Sanner, M. F., Griffin, J. H. Activated protein C light chain provides an extended binding surface for its anticoagulant cofactor, protein S Blood Advances  2017 1:1423-1426  DOI:10.1182/bloodadvances.2017007005  PMID:29296783  PMCID:PMC5727852
• Healy, L. D., Puy, C., Fernandez, J. A., Mitrugno, A., Keshari, R. S., Taku, N. A., Chu, T. T., Xu, X., Gruber, A., Lupu, F., Griffin, J. H., McCarty, O. J. T. Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo Journal of Biological Chemistry  2017 292:8616-8629  DOI:10.1074/jbc.M116.768309  PMID:28408624  PMCID:PMC5448091
• Griffin, J. H., Mosnier, L. O., Fernandez, J. A., Zlokovic, B. V. 2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis. Thrombotic stroke: neuroprotective therapy by recombinant-activated protein C Arteriosclerosis Thrombosis and Vascular Biology  2016 36:2143-2151  DOI:10.1161/atvbaha.116.308038  PMID:27758767  PMCID:PMC5119536
• Deguchi, H., Sinha, R. K., Marchese, P., Ruggeri, Z. M., Zilberman-Rudenko, J., McCarty, O. J. T., Cohen, M. J., Griffin, J. H. Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va Blood  2016 128:1870-1878  DOI:10.1182/blood-2016-03-707679  PMID:27421960  PMCID:PMC5054698
• Wang, Y., Zhao, Z., Rege, S. V., Wang, M., Si, G., Zhou, Y., Wang, S., Griffin, J. H., Goldman, S. A., Zlokovic, B. V. 3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice Nature Medicine  2016 22:1050-1055  DOI:10.1038/nm.4154  PMID:27548576
• Burnier, L., Boroujerdi, A., Fernandez, J. A., Welser-Alves, J. V., Griffin, J. H., Milner, R. Physiological cerebrovascular remodeling in response to chronic mild hypoxia: A role for activated protein C Experimental Neurology  2016 283:396-403  DOI:10.1016/j.expneurol.2016.07.004  PMID:27412766  PMCID:PMC4992591
• Alsultan, A., Gale, A. J., Kurban, K., Khalifah, M., Albadr, F. B., Griffin, J. H. Activation-resistant homozygous protein C R229W mutation causing familial perinatal intracranial hemorrhage and delayed onset of thrombosis Thrombosis Research  2016 143:17-21  DOI:10.1016/j.thromres.2016.04.011  PMID:27172833  PMCID:PMC4943460
• Gale, A. J., Bhat, V., Pellequer, J. L., Griffin, J. H., Mosnier, L. O., Von Drygalski, A. Safety, stability and pharmacokinetic properties of (super)Factor Va, a novel engineered coagulation Factor V for treatment of severe bleeding Pharmaceutical Research  2016 33:1517-1526  DOI:10.1007/s11095-016-1895-3  PMID:26960296  PMCID:PMC4854778
• Griffin, J. H., Fernandez, J. A., Lyden, P. D., Zlokovic, B. V. Activated protein C promotes neuroprotection: mechanisms and translation to the clinic Thrombosis Research  2016 141:S62-S64  DOI:10.1016/S0049-3848(16)30368-1  PMID:27207428  PMCID:PMC4904825
• Sinha, R. K., Yang, X. V., Fernandez, J. A., Xu, X., Mosnier, L. O., Griffin, J. H. Apolipoprotein E receptor 2 mediates activated protein C-induced endothelial Akt activation and endothelial barrier stabilization Arteriosclerosis Thrombosis and Vascular Biology  2016 36:518-524  DOI:10.1161/atvbaha.115.306795  PMID:26800564  PMCID:PMC4816599
• Bhat, V., von Drygalski, A., Gale, A. J., Griffin, J. H., Mosnier, L. O. Improved coagulation and haemostasis in haemophilia with inhibitors by combinations of superFactor Va and Factor VIIa Thrombosis and Haemostasis  2016 115:551-561  DOI:10.1160/th15-07-0525  PMID:26466980  PMCID:PMC4775351
• Deguchi, H., Banerjee, Y., Elias, D. J., Griffin, J. H. Elevated CETP lipid transfer activity is associated with the risk of venous thromboembolism Journal of Atherosclerosis and Thrombosis  2016 23:1159-1167  DOI:10.5551/jat.32201  PMID:27169917  PMCID:PMC5064881
• Liang, H. P. H., Kerschen, E. J., Basu, S., Hernandez, I., Zogg, M., Jia, S., Hessner, M. J., Toso, R., Rezaie, A. R., Fernandez, J. A., Camire, R. M., Ruf, W., et al. Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice Blood  2015 126:2415-2423  DOI:10.1182/blood-2015-05-644401  PMID:26341257  PMCID:PMC4653768
• Banno, F., Kita, T., Fernandez, J. A., Yanamoto, H., Tashima, Y., Kokame, K., Griffin, J. H., Miyata, T. Exacerbated venous thromboembolism in mice carrying a protein S K196E mutation Blood  2015 126:2247-2253  DOI:10.1182/blood-2015-06-653162  PMID:26251307  PMCID:PMC4635119
• Deguchi, H., Banerjee, Y., Trauger, S., Siuzdak, G., Kalisiak, E., Fernandez, J. A., Hoang, L., Tran, M., Yegneswaran, S., Elias, D. J., Griffin, J. H. Acylcarnitines are anticoagulants that inhibit factor Xa and are reduced in venous thrombosis, based on metabolomics data Blood  2015 126:1595-1600  DOI:10.1182/blood-2015-03-636761  PMID:26175037  PMCID:PMC4582336
• Amar, A. P., Griffin, J. H., Zlokovic, B. V. Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke Frontiers in Cellular Neuroscience  2015 9:344  DOI:10.3389/fncel.2015.00344  PMID:26388732  PMCID:PMC4556986
• Yegneswaran, S., Banerjee, Y., Fernandez, J. A., Deguchi, H., Griffin, J. H. Lyso-sulfatide binds factor Xa and inhibits thrombin generation by the prothrombinase complex PLoS One  2015 10:e0135025  DOI:10.1371/journal.pone.0135025  PMID:26263376  PMCID:PMC4532512
• Ivanisevic, J., Elias, D., Deguchi, H., Averell, P. M., Kurczy, M., Johnson, C. H., Tautenhahn, R., Zhu, Z., Watrous, J., Jain, M., Griffin, J., Patti, G. J., et al. Arteriovenous blood metabolomics: a readout of intra-tissue metabostasis Scientific Reports  2015 5:12757  DOI:10.1038/srep12757  PMID:26244428  PMCID:PMC4525490
• Griffin, J. H., Zlokovic, B. V., Mosnier, L. O. Activated protein C: biased for translation Blood  2015 125:2898-2907  DOI:10.1182/blood-2015-02-355974  PMID:25824691  PMCID:PMC4424414
• Liang, H. P. H., Kerschen, E. J., Hernandez, I., Basu, S., Zogg, M., Botros, F., Jia, S., Hessner, M. J., Griffin, J. H., Ruf, W., Weiler, H. EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice Blood  2015 125:2845-2854  DOI:10.1182/blood-2014-11-610717  PMID:25733582  PMCID:PMC4424632
• Mosnier, L. O., Zlokovic, B. V., Griffin, J. H. Cytoprotective-selective activated protein C therapy for ischaemic stroke Thrombosis and Haemostasis  2014 112:883-892  DOI:10.1160/th14-05-0448  PMID:25230930
• von Drygalski, A., Bhat, V., Gale, A. J., Burnier, L., Cramer, T. J., Griffin, J. H., Mosnier, L. O. An engineered Factor Va prevents bleeding induced by anticoagulant wt activated protein C PLoS One  2014 9:e104304  DOI:10.1371/journal.pone.0104304  PMID:25127130  PMCID:PMC4134195
• Deguchi, H., Elias, D. J., Trauger, S., Zhang, H. M., Kalisiak, E., Siuzdak, G., Griffin, J. H. Warfarin untargeted metabolomics study identifies novel procoagulant ethanolamide plasma lipids British Journal of Haematology  2014 165:409-412  DOI:10.1111/bjh.12720  PMID:24450944  PMCID:PMC3984601
• Winkler, E. A., Sengillo, J. D., Sagare, A. P., Zhao, Z., Ma, Q., Zuniga, E., Wang, Y., Zhong, Z., Sullivan, J. S., Griffin, J. H., Cleveland, D. W., Zlokovic, B. V. Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice Proceedings of the National Academy of Sciences of the United States of America  2014 111:E1035-E1042  DOI:10.1073/pnas.1401595111  PMID:24591593  PMCID:PMC3964055
• von Drygalski, A., Cramer, T. J., Bhat, V., Griffin, J. H., Gale, A. J., Mosnier, L. O. Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant Journal of Thrombosis and Haemostasis  2014 12:363-372  DOI:10.1111/jth.12489  PMID:24818532  PMCID:PMC4161283
• Deguchi, H., Elias, D. J., Griffin, J. H. Gain in translation: heme oxygenase-1 induced by activated protein C promotes thrombus resolution Journal of Thrombosis and Haemostasis  2014 12:90-92  DOI:10.1111/jth.12446  PMID:24406066  PMCID:PMC4062081
• Wang, Y., Zhao, Z., Chow, N., Rajput, P. S., Griffin, J. H., Lyden, P. D., Zlokovic, B. V. Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats Stroke  2013 44:3529-3536  DOI:10.1161/strokeaha.113.003350  PMID:24159062
• Lyden, P., Levy, H., Weymer, S., Pryor, K., Kramer, W., Griffin, J. H., Davis, T. P., Zlokovic, B. Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers Current Pharmaceutical Design  2013 19:7479-7485  PMID:24372304  PMCID:PMC4040367
• Mosnier, L. O., Fernandez, J. A., Davis, T. P., Zlokovic, B. V., Griffin, J. H. Influence of the 3K3A-activated protein C variant on the plasma clot lysis activity of t-PA and of t-PA on the variant's anticoagulant activity Journal of Thrombosis and Haemostasis  2013 11:2059-2062  DOI:10.1111/jth.12400  PMID:24034518  PMCID:PMC3850769
• Wang, Y., Sinha, R. K., Mosnier, L. O., Griffin, J. H., Zlokovic, B. V. Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice Blood Cells Molecules and Diseases  2013 51:104-108  DOI:10.1016/j.bcmd2013.02.009  PMID:23541526
• Heeb, M. J., Mesters, R. M., Fernandez, J. A., Hackeng, T. M., Nakasone, R. K., Griffin, J. H. Plasma protein S residues 37-50 mediate its binding to factor Va and inhibition of blood coagulation Thrombosis and Haemostasis  2013 110:275-282  DOI:10.1160/th12-12-0953  PMID:23892573  PMCID:PMC3733499
• Wang, Y., Zhao, Z., Chow, N., Ali, T., Griffin, J. H., Zlokovic, B. V. Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1 Brain Research  2013 1507:97-104  DOI:10.1016/j.brainres.2013.02.023  PMID:23438513  PMCID:PMC3739836
• Guo, H., Zhao, Z., Yang, Q., Wang, M., Bell, R. D., Wang, S., Chow, N., Davis, T. P., Griffin, J. H., Goldman, S. A., Zlokovic, B. V. An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway Journal of Neuroscience  2013 33:6181-6190  DOI:10.1523/jneurosci.4491-12.2013  PMID:23554499
• Burnier, L., Fernandez, J. A., Griffin, J. H. Antibody SPC-54 provides acute in vivo blockage of the murine protein C system Blood Cells, Molecules, and Diseases  2013 50:252-8  DOI:10.1016/j.bcmd.2013.01.002  PMID:23385154  PMCID:PMC3594351
• von Drygalski, A., Furlan-Freguia, C., Ruf, W., Griffin, J. H., Mosnier, L. O. Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor Arteriosclerosis, Thrombosis, and Vascular Biology  2013 33:769-776  DOI:10.1161/atvbaha.112.301082  PMID:23393392
• Deguchi, H., Elias, D. J., Navarro, S., Espana, F., Griffin, J. H. Elevated serum amyloid A is associated with venous thromboembolism Thrombosis and Haemostasis  2013 109:358-359  DOI:10.1160/th12-10-0722  PMID:23255027  PMCID:PMC3579663
• Mosnier, L. O., Sinha, R. K., Burnier, L., Bouwens, E. A., Griffin, J. H. Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46 Blood  2012 120:5237-5246  DOI:10.1182/blood-2012-08-452169  PMID:23149848  PMCID:PMC3537315
• Van de Vijver, P., Schmitt, M., Suylen, D., Scheer, L., Thomassen, Mclgd, Schurgers, L. J., Griffin, J. H., Koenen, R. R., Hackeng, T. M. Incorporation of disulfide containing protein modules into multivalent antigenic conjugates: Generation of antibodies against the thrombin-sensitive region of murine protein S Journal of the American Chemical Society  2012 134:19318-19321  DOI:10.1021/ja306993t  PMID:23066897
• von Drygalski, A., Furlan-Freguia, C., Mosnier, L. O., Yegneswaran, S., Ruf, W., Griffin, J. H. Infrared fluorescence for vascular barrier breach in vivo - a novel method for quantitation of albumin efflux Thrombosis and Haemostasis  2012 108:981-991  DOI:10.1160/th12-03-0196  PMID:23052565  PMCID:PMC3597782
• Wang, Y. M., Zhang, Z. G., Chow, N., Davis, T. P., Griffin, J. H., Chopp, M., Zlokovic, B. V. An activated protein c analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents Stroke  2012 43:2444-2449  DOI:10.1161/strokeaha.112.658997  PMID:22811462  PMCID:PMC3429704
• Williams, P. D., Zlokovic, B. V., Griffin, J. H., Pryor, K. E., Davis, T. P. Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke Current Pharmaceutical Design  2012 18:4215-4222  DOI:10.2174/138161212802430413  PMID:22632606  PMCID:PMC3472038
• Geiger, H., Pawar, S. A., Kerschen, E. J., Nattamai, K. J., Hernandez, I., Liang, H. P. H., Fernandez, J. A., Cancelas, J. A., Ryan, M. A., Kustikova, O., Schambach, A., Fu, Q., et al. Pharmacological targeting of the thrombomodulin-activated protein c pathway mitigates radiation toxicity Nature Medicine  2012 18:1123-9  DOI:10.1038/nm.2813  PMID:22729286  PMCID:PMC3491776
• Hansen, J. B., Fernandez, J. A., Borch, K. H., Griffin, J. H., Brox, J. H., Braekkan, S. K. Activated protein C plasma levels in the fasting and postprandial states among patients with previous unprovoked venous thromboembolism Thrombosis Research  2012 129:502-507  DOI:10.1016/j.thromres.2011.06.026  PMID:21777953  PMCID:PMC3480311
• Griffin, J. H., Zlokovic, B. V., Mosnier, L. O. Protein c anticoagulant and cytoprotective pathways International Journal of Hematology  2012 95:333-345  DOI:10.1007/s12185-012-1059-0  PMID:22477541  PMCID:PMC3413316
• Madhusudhan, T., Wang, H. J., Straub, B. K., Grone, E., Zhou, Q. X., Shahzad, K., Muller-Krebs, S., Schwenger, V., Gerlitz, B., Grinnell, B. W., Griffin, J. H., Reiser, J., et al. Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes Blood  2012 119:874-883  DOI:10.1182/blood-2011-07-365973  PMID:22117049  PMCID:PMC3398751
• Raife, T. J., Dwyre, D. M., Stevens, J. W., Erger, R. A., Leo, L., Wilson, K. M., Fernandez, J. A., Wilder, J., Kim, H. S., Griffin, J. H., Maeda, N., Lentz, S. R. Human thrombomodulin knock-in mice reveal differential effects of human thrombomodulin on thrombosis and atherosclerosis Arteriosclerosis, Thrombosis, and Vascular Biology  2011 31:2509-2517  DOI:10.1161/atvbaha.111.236828  PMID:21885846  PMCID:PMC3202707
• Bir, N., Lafargue, M., Howard, M., Goolaerts, A., Roux, J., Carles, M., Cohen, M. J., Iles, K. E., Fernandez, J. A., Griffin, J. H., Pittet, J. F. Cytoprotective-selective activated protein C attenuates pseudomonas aeruginosa-induced lung injury in mice American Journal of Respiratory Cell and Molecular Biology  2011 45:632-641  DOI:10.1165/rcmb.2010-0397OC  PMID:21257925  PMCID:PMC3175583
• Zlokovic, B. V., Griffin, J. H. Cytoprotective protein C pathways and implications for stroke and neurological disorders Trends in Neurosciences  2011 34:198-209  DOI:10.1016/j.tins.2011.01.005  PMID:21353711  PMCID:PMC3491752
• Guo, H. A., Barrett, T. M., Zhong, Z. H., Fernandez, J. A., Griffin, J. H., Freeman, R. S., Zlokovic, B. V. Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway Molecular Neurodegeneration  2011 6:13  DOI:10.1186/1750-1326-6-13  PMID:21291561  PMCID:PMC3042387
• Zhong, Z. H., Wang, Y. M., Guo, H. A., Sagare, A., Fernandez, J. A., Bell, R. D., Barrett, T. M., Griffin, J. H., Freeman, R. S., Zlokovic, B. V. Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region Journal of Neuroscience  2010 30:15521-15534  DOI:10.1523/jneurosci.4437-10.2010  PMID:21084607  PMCID:PMC3012432
• Cheung, M. C., Albers, J. J., Kennedy, H., Deguchi, H., Elias, D. J., Averell, P. M., Griffin, J. H., Marcovina, S. M. Association of Apo(a)isoform size with dyslipoproteinemia in male venous thrombosis patients Clinica Chimica Acta  2010 411:1279-1283  DOI:10.1016/j.cca.2010.05.012  PMID:20488173  PMCID:PMC3427714
• Kerschen, E., Hernandez, I., Zogg, M., Jia, S. A., Hessner, M. J., Fernandez, J. A., Griffin, J. H., Huettner, C. S., Castellino, F. J., Weiler, H. Activated protein C targets CD8(+) dendritic cells to reduce the mortality of endotoxemia in mice Journal of Clinical Investigation  2010 120:3167-3178  DOI:10.1172/jci42629  PMID:20714108  PMCID:PMC2929901
• Cramer, T. J., Griffin, J. H., Gale, A. J. Factor V is an anticoagulant cofactor for activated protein C during inactivation of factor Va Pathophysiology of Haemostasis and Thrombosis  2010 37:17-23  DOI:10.1159/000315141  PMID:20501981  PMCID:PMC2974842
• Fernandez, J. A., Heeb, M. J., Xu, X., Singh, I., Zlokovic, B. V., Griffin, J. H. Species-specific anticoagulant and mitogenic activities of murine protein S Haematologica-The Hematology Journal  2009 94:1721-1731  DOI:10.3324/haematol.2009.009233  PMID:19815836  PMCID:PMC2791928
• Zhong, Z. H., Ilieva, H., Hallagan, L., Bell, R., Singh, I., Paquette, N., Thiyagarajan, M., Deane, R., Fernandez, J. A., Lane, S., Zlokovic, A. B., Liu, T., et al. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells Journal of Clinical Investigation  2009 119:3437-3449  DOI:10.1172/jci38476  PMID:19841542  PMCID:PMC2769191
• Saller, F., Brisset, A. C., Tchaikovski, S. N., Azevedo, M., Chrast, R., Fernandez, J. A., Schapira, M., Hackeng, T. M., Griffin, J. H., Angelillo-Scherrer, A. Generation and phenotypic analysis of protein S-deficient mice Blood  2009 114:2307-2314  DOI:10.1182/blood-2009-03-209031  PMID:19567881  PMCID:PMC2745849
• Heeb, M. J., Prashun, D., Griffin, J. H., Bouma, B. N. Plasma protein S contains zinc essential for efficient activated protein C-independent anticoagulant activity and binding to factor Xa, but not for efficient binding to tissue factor pathway inhibitor FASEB Journal  2009 23:2244-2253  DOI:10.1096/fj.08-123174  PMID:19244162  PMCID:PMC2704590
• Mosnier, L. O., Zampolli, A., Kerschen, E. J., Schuepbach, R. A., Banerjee, Y., Fernandez, J. A., Yang, X. V., Riewald, M., Weiler, H., Ruggeri, Z. M., Griffin, J. H. Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant Blood  2009 113:5970-5978  DOI:10.1182/blood-2008-10-183327  PMID:19244160  PMCID:PMC2700330
• Schuepbach, R. A., Feistritzer, C., Fernandez, J. A., Griffin, J. H., Riewald, M. Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1 Thrombosis and Haemostasis  2009 101:724-733  DOI:10.1160/th08-10-0632  PMID:19350118  PMCID:PMC2680237
• Guo, H., Wang, Y. M., Singh, I., Liu, D., Fernandez, J. A., Griffin, J. H., Chow, N., Zlokovic, B. V. Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity Journal of Neurochemistry  2009 109:116-124  DOI:10.1111/j.1471-4159.2009.05921.x  PMID:19166505  PMCID:PMC2692505
• Cheung, M. C., Wolfbauer, G., Deguchi, H., Fernandez, J. A., Griffin, J. H., Albers, J. J. Human plasma phospholipid transfer protein specific activity is correlated with HDL size: Implications for lipoprotein physiology Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids  2009 1791:206-211  DOI:10.1016/j.bbalip.2008.12.010  PMID:19162221  PMCID:PMC2733856
• Guo, H., Singh, I., Wang, Y. M., Deane, R., Barrett, T., Fernandez, J. A., Chow, N., Griffin, J. H., Zlokovic, B. V. Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity European Journal of Neuroscience  2009 29:1119-1130  DOI:10.1111/j.1460-9568.2009.06664.x  PMID:19302148  PMCID:PMC2692517
• Yang, X. V., Banerjee, Y., Fernandez, J. A., Deguchi, H., Xu, X., Mosnier, L. O., Urbanus, R. T., de Groot, P. G., White-Adams, T. C., McCarty, O. J. T., Griffin, J. H. Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells Proceedings of the National Academy of Sciences of the United States of America  2009 106:274-279  DOI:10.1073/pnas.0807594106  PMID:19116273  PMCID:PMC2629184
• Yegneswaran, S., Nguyen, P. M., Gale, A. J., Griffin, J. H. Prothrombin amino terminal region helps protect coagulation factor Va from proteolytic inactivation by activated protein C Thrombosis and Haemostasis  2009 101:55-61  DOI:10.1160/th08-07-0491  PMID:19132189  PMCID:PMC2730196
• Yegneswaran, S., Hackeng, T. M., Dawson, P. E., Griffin, J. H. The thrombin-sensitive region of protein S mediates phospholipid-dependent interaction with factor Xa Journal of Biological Chemistry  2008 283:33046-33052  DOI:10.1074/jbc.M806527200  PMID:18784085  PMCID:PMC2586267
• Thiyagarajan, M., Fernandez, J. A., Lane, S. M., Griffin, J. H., Zlokovic, B. V. Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1 Journal of Neuroscience  2008 28:12788-12797  DOI:10.1523/jneurosci.3485-08.2008  PMID:19036971  PMCID:PMC2742231
• Pecheniuk, N. M., Elias, D. J., Deguchi, H., Averell, P. M., Griffin, J. H. Elevated plasma fibronectin levels associated with venous thromboembolism Thrombosis and Haemostasis  2008 100:224-228  DOI:10.1160/th08-02-0078  PMID:18690341  PMCID:PMC2909754
• Heeb, M. J., Gandrille, S., Fernandez, J. A., Griffin, J. H., Fedullo, P. F. Late onset thrombosis in a case of severe protein S deficiency due to compound heterozygosity for PROS1 mutations Journal of Thrombosis and Haemostasis  2008 6:1235-1237  DOI:10.1111/j.1538-7836.2008.02994.x  PMID:18433462  PMCID:PMC2632602
• White, T. C., Berny, M. A., Tucker, E. I., Urbanus, R. T., De Groot, P. G., Fernandez, J. A., Griffin, J. H., Gruber, A., McCarty, O. J. T. Protein C supports platelet binding and activation under flow: Role of glycoprotein Ib and apolipoprotein E receptor 2 Journal of Thrombosis and Haemostasis  2008 6:995-1002  DOI:10.1111/j.1538-7836.2008.02979.x  PMID:18489431
• Pecheniuk, N. M., Elias, D. J., Xu, X., Griffin, J. H. Failure to validate association of gene polymorphisms in EPCR, PAR-1, FSAP and protein S Tokushima with venous thromboembolism among Californians of European ancestry Thrombosis and Haemostasis  2008 99:453-455  DOI:10.1160/th07-10-0607  PMID:18278202
• Deguchi, H., Fernandez, J. A., Griffin, J. H. Plasma cholesteryl ester transfer protein and blood coagulability Thrombosis and Haemostasis  2007 98:1160-1164  DOI:10.1160/th07-07-0451  PMID:18064308
• Mosnier, L. O., Yang, X. V., Griffin, J. H. Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions Journal of Biological Chemistry  2007 282:33022-33033  DOI:10.1074/jbc.M705824200  PMID:17872949
• Kerschen, E. J., Fernandez, J. A., Cooley, B. C., Yang, X. V., Sood, R., Mosnier, L. O., Castellino, F. J., Mackman, N., Griffin, J. H., Weiler, H. Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C Journal of Experimental Medicine  2007 204:2439-2448  DOI:10.1084/jem.20070404  PMID:17893198  PMCID:PMC2118455
• Yegneswaran, S., Kojima, Y., Nguyen, P. M., Gale, A. J., Heeb, M. J., Griffin, J. H. Factor Va residues 311-325 represent an activated protein C binding region Journal of Biological Chemistry  2007 282:28353-28361  DOI:10.1074/jbc.M704316200  PMID:17646160
• Gale, A. J., Yegneswaran, S., Xu, X., Pellequer, J. L., Griffin, J. H. Characterization of a factor Xa binding site on factor Va near the Arg-506 activated protein C cleavage site Journal of Biological Chemistry  2007 282:21848-21855  DOI:10.1074/jbc.M702192200  PMID:17553804
• Griffin, J. H., Fernandez, J. A., Gale, A. J., Mosnier, L. O. Activated protein C Journal of Thrombosis and Haemostasis  2007 5:73-80  DOI:10.1111/j.1538-7836.2007.02491.x  PMID:17635713
• Gruber, A., Marzec, U. M., Bush, L., Di Cera, E., Fernandez, J. A., Berny, M. A., Tucker, E. I., McCarty, O. J. T., Griffin, J. H., Hanson, S. R. Relative antithrombotic and andhernostatic effects of protein C activator versus low-molecular-weight heparin in primates Blood  2007 109:3733-3740  DOI:10.1182/blood-2006-07-035147  PMID:17227834  PMCID:PMC1874578
• Mosnier, L. O., Zlokovic, B. V., Griffin, J. H. The cytoprotective protein C pathway Blood  2007 109:3161-3172  DOI:10.1182/blood-2006-09-003004  PMID:17110453
• Eichinger, S., Pecheniuk, N. M., Hron, G., Deguchi, H., Schemper, M., Kyrle, P. A., Griffin, J. H. High-density lipoprotein and the risk of recurrent venous thromboembolism Circulation  2007 115:1609-1614  DOI:10.1161/circulationaha.106.649954  PMID:17372172
• Raivio, P., Fernandez, J. A., Kuitunen, A., Griffin, J. H., Lassila, R., Petaja, J. Activation of protein C and hemodynamic recovery after coronary artery bypass surgery Journal of Thoracic and Cardiovascular Surgery  2007 133:44-51  DOI:10.1016/j.jtcvs.2006.10.003  PMID:17198779
• Radtke, K. P., Griffin, J. H., Riceberg, J., Gale, A. J. Disulfide bond-stabilized factor viii has prolonged factor viiia activity and improved potency in whole blood clotting assays Journal of Thrombosis and Haemostasis  2007 5:102-108  DOI:10.1111/j.1538-7836.2006.02283.x
• Cheng, T., Petraglia, A. L., Li, Z., Thiyagarajan, M., Zhong, Z. H., Wu, Z. H., Liu, D., Maggirwar, S. B., Deane, R., Fernandez, J. A., LaRue, B., Griffin, J. H., et al. Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage Nature Medicine  2006 12:1278-1285  DOI:10.1038/nm1498  PMID:17072311
• Pecheniuk, N. M., Deguchi, H., Elias, D. J., Xu, X., Griffin, J. H. Cholesteryl ester transfer protein genotypes associated with venous thrombosis and dyslipoproteinemia in males Journal of Thrombosis and Haemostasis  2006 4:2080-2082  DOI:10.1111/j.1538-7836.2006.02099.x  PMID:16961620
• Mosnier, L. O., Griffin, J. H. Protein C anticoagulant activity in relation to anti-inflammatory and anti-apoptotic activities Frontiers in Bioscience  2006 11:2381-2399  DOI:10.2741/1977  PMID:16720321
• Fernandez, J. A., Lentz, S. R., Dwyre, D. M., Griffin, J. H. A novel ELISA for mouse activated protein C in plasma Journal of Immunological Methods  2006 314:174-181  DOI:10.1016/j.jim.2006.05.004  PMID:16828789
• Feistritzer, C., Schuepbach, R. A., Mosnier, L. O., Bush, L. A., Di Cera, E., Griffin, J. H., Riewald, M. Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells Journal of Biological Chemistry  2006 281:20077-20084  DOI:10.1074/jbc.M600506200  PMID:16709569
• Mineo, C., Deguchi, H., Griffin, J. H., Shaul, P. W. Endothelial and antithrombotic actions of HDL Circulation Research  2006 98:1352-1364  DOI:10.1161/01.res.0000225982.01988.93  PMID:16763172
• Gale, A. J., Radtke, K. P., Cunningham, M. A., Chamberlain, D., Pellequer, J. L., Griffin, J. H. Intrinsic stability and functional properties of disulfide bond-stabilized coagulation factor VIIIa variants Journal of Thrombosis and Haemostasis  2006 4:1315-1322  DOI:10.1111/j.1538-7836.2006.01951.x  PMID:16706977
• Bushnell, C. D., Griffin, J., Newby, L. K., Goldstein, L. B., Mahaffey, K. W., Graffagnino, C. A., Harrington, R. A., White, H. D., Simes, R. J., Califf, R. M., Topol, E. J., Easton, J. D. Statin use and sex-specific stroke outcomes in patients with vascular disease Stroke  2006 37:1427-1431  DOI:10.1161/01.STR.0000221315.60282.ca  PMID:16645137
• Fernandez, J. A., Pecheniuk, N. M., Deguchi, H., Elias, D. J., Griffin, J. H. Is adiponectin implicated in venous thromboembolism? Journal of Thrombosis and Haemostasis  2006 4:1151-1152  DOI:10.1111/j.1538-7836.2006.01897.x  PMID:16689775
• Fernandez, J. A., Vento, A. E., Jormalainen, M., Griffin, J. H., Pseonen, E., Syrjala, M., Repo, H., Jansson, S. E., Ramo, O. J., Petaja, J. Activated protein C in the cardioplegic solution on a porcine model of coronary ischemia-reperfusion has deleterious hemodynamic effects Cardiovascular Drugs and Therapy  2006 20:113-121  DOI:10.1007/s10557-006-7448-y  PMID:16761191
• Griffin, J. H., Fernandez, J. A., Mosnier, L. O., Liu, D., Cheng, T., Guo, H., Zlokovic, B. V. The promise of protein C Blood Cells Molecules and Diseases  2006 36:211-216  DOI:10.1016/j,bcmd.2005.12.023  PMID:16464623
• Ilmakunnas, M., Pesonen, E. J., Hockerstedt, K., Makisalo, H., Fernandez, J. A., Griffin, J. H., Repo, H., Siitonen, S., Petaja, J. Graft protein C entrapment is associated with reduced phagocyte activation during reperfusion in human liver transplantation Critical Care Medicine  2006 34:426-432  DOI:10.1097/01.ccm.0000198108.38349.28  PMID:16424724
• Gruber, A., Fernandez, J. A., Bush, L., Marzec, U., Griffin, J. H., Hanson, S. R., Di Cera, E. Limited generation of activated protein C during infusion of the protein C activator thrombin analog W215A/E217A in primates Journal of Thrombosis and Haemostasis  2006 4:392-397  DOI:10.1111/j.1538-7836.2006.01760.x  PMID:16420571
• Tanaka, K. A., Fernandez, J. A., Marzec, U. M., Kelly, A. B., Mohri, M., Griffin, J. H., Hanson, S. R., Gruber, A. Soluble thrombomodulin is antithrombotic in the presence of neutralising antibodies to protein C and reduces circulating activated protein C levels in primates British Journal of Haematology  2006 132:197-203  DOI:10.1111/j.1365-2141.2005.05855.x  PMID:16398653
• Lindstrom, O., Kylanpaa, L., Mentula, P., Puolakkainen, P., Kemppainen, E., Haapiainen, R., Fernandez, J. A., Griffin, J. H., Repo, H., Petaja, J. Upregulated but insufficient generation of activated protein C is associated with development of multiorgan failure in severe acute pancreatitis Critical Care  2006 10:R16  DOI:10.1186/cc3966  PMID:16420659  PMCID:PMC1550818
• Turunen, A. J., Fernandez, J. A., Lindgren, L., Salmela, K. T., Kyllonen, L. E., Makisalo, H., Griffin, J. H., Siitonen, S. M., Petaja, J., Pesonen, E. J. Activated protein C reduces graft neutrophil activation in clinical renal transplantation American Journal of Transplantation  2005 5:2204-2212  DOI:10.1111/j.1600-6143.2005.00994.x  PMID:16095499
• Zlokovic, B. V., Zhang, C. L., Liu, D., Fernandez, J., Griffin, J. H., Chopp, M. Functional recovery after embolic stroke in rodents by activated protein C Annals of Neurology  2005 58:474-477  DOI:10.1002/ana.20602  PMID:16130108
• Deguchi, H., Pecheniuk, N. M., Elias, D. J., Averell, P. M., Griffin, J. H. High-density lipoprotein deficiency and dyslipoproteinemia associated with venous thrombosis in men Circulation  2005 112:893-899  DOI:10.1161/circulationaha.104.521344  PMID:16087810
• Deguchi, H., Bouma, B. N., Middeldorp, S., Lee, Y. M., Griffin, J. H. Decreased plasma sensitivity to activated protein C by oral contraceptives is associated with decreases in plasma glucosylceramide Journal of Thrombosis and Haemostasis  2005 3:935-938  DOI:10.1111/j.1538-7836.2005.01335.x  PMID:15869587
• Pecheniuk, N. M., Deguchi, H., Griffin, J. H. Cholesterol enhances phospholipid-dependent activated protein c anticoagulant activity Journal of Thrombosis and Haemostasis  2005 3:340-345  DOI:10.1111/j.1538-7836.2005.01112.x  PMID:15670041
• Liu, D., Cheng, T., Guo, H., Fernandez, J. A., Griffin, J. H., Song, X. M., Zlokovic, B. V. Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C Nature Medicine  2004 10:1379-1383  DOI:10.1038/nm1122  PMID:15516929
• Yegneswaran, S., Mesters, R. M., Fernandez, J. A., Griffin, J. H. Prothrombin residues 473-487 contribute to factor Va binding in the prothrombinase complex Journal of Biological Chemistry  2004 279:49019-49025  DOI:10.1074/jbc.M406654200  PMID:15331602  PMCID:PMC2911622
• Contreras, J. L., Eckstein, C., Smyth, C. A., Bilbao, G., Vilatoba, M., Ringland, S. E., Young, C., Thompson, J. A., Fernandez, J. A., Griffin, J. H., Eckhoff, D. E. Activated protein C preserves functional islet mass after intraportal transplantation - a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death Diabetes  2004 53:2804-2814  DOI:10.2337/diabetes.53.11.2804  PMID:15504960
• Leiba, M., Seligsohn, U., Sidi, Y., Harats, D., Sela, B. A., Griffin, J. H., Livneh, A., Rosenberg, N., Gelernter, I., Gur, H., Ehrenfeld, M. Thrombophilic factors are not the leading cause of thrombosis in Behcet's disease Annals of the Rheumatic Diseases  2004 63:1445-1449  DOI:10.1136/ard.2003.014241  PMID:15479893  PMCID:PMC1754810
• Mosnier, L. O., Gale, A. J., Yegneswaran, S., Griffin, J. H. Activated protein C variants with normal cytoprotective but reduced anticoagulant activity Blood  2004 104:1740-1744  DOI:10.1182/blood-2004-01-0110  PMID:15178575
• Griffin, J. H., Fernandez, J. A., Liu, D., Cheng, T., Guo, H., Zlokovic, B. V. Activated protein C and ischemic stroke Critical Care Medicine  2004 32:S247-S253  DOI:10.1097/01.cmm.0000126127.87484.2b  PMID:15118526
• Deguchi, H., Yegneswaran, S., Griffin, J. H. Sphingolipids as bioactive regulators of thrombin generation Journal of Biological Chemistry  2004 279:12036-12042  DOI:10.1074/jbc.M302531200  PMID:14722105
• Guo, H., Liu, D., Gelbard, H., Cheng, T., Insalaco, R., Fernandez, J. A., Griffin, J. H., Zlokovic, B. V. Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3 Neuron  2004 41:563-572  DOI:10.1016/s0896-6273(04)00019-4  PMID:14980205
• Gale, A. J., Griffin, J. H. Characterization of a thrombomodulin binding site on protein C and its comparison to an activated protein C binding site for factor Va Proteins-Structure Function and Genetics  2004 54:433-441  DOI:10.1002/prot.10627  PMID:14747992
• Yegneswaran, S., Mesters, R. M., Griffin, J. H. Identification of distinct sequences in human blood coagulation factor Xa and prothrombin essential for substrate and cofactor recognition in the prothrombinase complex Journal of Biological Chemistry  2003 278:33312-33318  DOI:10.1074/jbc.M305906200  PMID:12805370
• Mosnier, L. O., Griffin, J. H. Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor Biochemical Journal  2003 373:65-70  DOI:10.1042/bj20030341  PMID:12683950
• Slungaard, A., Fernandez, J. A., Griffin, J. H., Key, N. S., Long, J. R., Piegors, D. J., Lentz, S. R. Platelet factor 4 enhances generation of activated protein C in vitro and in vivo Blood  2003 102:146-151  DOI:10.1182/blood-2002-11-3529  PMID:12609838
• Domotor, E., Benzakour, O., Griffin, J. H., Yule, D., Fukudome, K., Zlokovic, B. V. Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1 Blood  2003 101:4797-4801  DOI:10.1182/blood-2002-12-3680  PMID:12586611
• Fernandez, J. A., Xu, X., Liu, D., Zlokovic, B. V., Griffin, J. H. Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model Blood Cells Molecules and Diseases  2003 30:271-276  DOI:10.1016/s1079-9796(03)00034-2  PMID:12737945
• Yegneswaran, S., Deguchi, H., Griffin, J. H. Glucosylceramide, a neutral glycosphingolipid anticoagulant cofactor, enhances the interaction of human- and bovine-activated protein C with negatively charged phospholipid vesicles Journal of Biological Chemistry  2003 278:14614-14621  DOI:10.1074/jbc.M206746200  PMID:12560338
• Liu, D., Guo, H., Griffin, J. H., Fernandez, J. A., Zlokovic, B. V. Protein S confers neuronal protection during ischemic/hypoxic injury in mice Circulation  2003 107:1791-1796  DOI:10.1161/01.cir.0000058460.34453.5a  PMID:12665496
• Cheng, T., Liu, D., Griffin, J. H., Fernandez, J. A., Castellino, F., Rosen, E. D., Fukudome, K., Zlokovic, B. V. Activated protein c blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective Nature Medicine  2003 9:338-342  DOI:10.1038/nm826  PMID:12563316
• Ilmakunnas, M., Petaja, J., Hockerstedt, K., Makisalo, H., Fernandez, J. A., Griffin, J. H., Jansson, S. E., Repo, H., Pesonen, E. J. Activation of protein C during reperfusion in clinical liver transplantation Transplantation  2003 75:467-472  DOI:10.1097/01.tp.0000046529.83650.8a  PMID:12605111
• Simmelink, M. J. A., de Groot, P. G., Derksen, Rhwm, Fernandez, J. A., Griffin, J. H. Oral anticoagulation reduces activated protein C less than protein C and other vitamin K-dependent clotting factors Blood  2002 100:4232-4233  DOI:10.1182/blood-2002-01-0329  PMID:12393585
• Khrenov, A. V., Ananyeva, N. M., Griffin, J. H., Saenko, E. L. Coagulation pathways in atherothrombosis Trends in Cardiovascular Medicine  2002 12:317-324  DOI:10.1016/s1050-1738(02)00182-2  PMID:12458095
• Lentz, S. R., Piegors, D. J., Fernandez, J. A., Erger, R. A., Arning, E., Malinow, M. R., Griffin, J. H., Bottiglieri, T., Haynes, W. G., Heistad, D. D. Effect of hyperhomocysteinemia on protein C activation and activity Blood  2002 100:2108-2112  DOI:10.1182/blood-2002-03-0727  PMID:12200374
• Heeb, M. J., Griffin, J. H. Activated protein C-dependent and -independent anticoagulant activities of protein S have different structural requirements Blood Cells Molecules and Diseases  2002 29:190-199  DOI:10.1006/bcmd.2002.0558  PMID:12490286
• Gale, A. J., Xu, X., Pellequer, J. L., Getzoff, E. D., Griffin, J. H. Interdomain engineered disulfide bond permitting elucidation of mechanisms of inactivation of coagulation factor Va by activated protein C Protein Science  2002 11:2091-2101  DOI:10.1110/ps.0210002  PMID:12192065  PMCID:PMC2373598
• Heeb, M. J., Paganini-Hill, A., Griffin, J. H., Fisher, M. Low protein Z levels and risk of ischemic stroke: differences by diabetic status and gender Blood Cells Molecules and Diseases  2002 29:139-144  DOI:10.1006/bcmd.2002.0549  PMID:12490280
• Lentz, S. R., Miller, F. J., Piegors, D. J., Erger, R. A., Fernandez, J. A., Griffin, J. H., Heistad, D. D. Anticoagulant responses to thrombin are enhanced during regression of atherosclerosis in monkeys Circulation  2002 106:842-846  DOI:10.1161/01.cir.0000024982.11646.25  PMID:12176958
• Gale, A. J., Tsavaler, A., Griffin, J. H. Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C Journal of Biological Chemistry  2002 277:28836-28840  DOI:10.1074/jbc.M204363200  PMID:12063259
• Kottke-Marchant, K., Bahit, M. C., Granger, C. B., Zoldhelyi, P., Ardissino, D., Brooks, L., Griffin, J. H., Potthoff, R. F., Van de Werf, F., Califf, R. M., Topol, E. J. Effect of hirudin vs heparin on haemostatic activity in patients with acute coronary syndromes - the GUSTO-IIb haemostasis substudy European Heart Journal  2002 23:1202-1212  DOI:10.1053/euhj.2001.3074  PMID:12127922
• Griffin, J. H., Zlokovic, B., Fernandez, J. A. Activated protein C: Potential therapy for severe sepsis, thrombosis, and stroke Seminars in Hematology  2002 39:197-205  DOI:10.1053/shem.2002.2002.34093  PMID:12124682
• Fernandez, J. A., Gruber, A., Heeb, M. J., Griffin, J. H. Protein C pathway impairment in nonsymptomatic cigarette smokers Blood Cells Molecules and Diseases  2002 29:73-82  DOI:10.1006/bcmd.2002.0542  PMID:12482406
• Simmelink, M. J. A., Fernandez, J. A., Derksen, Rhwm, Griffin, J. H., de Groot, P. G. Low levels of activated protein C in patients with systemic lupus erythematosus do not relate to lupus anticoagulants but to low levels of factor II British Journal of Haematology  2002 117:676-684  DOI:10.1046/j.1365-2141.2002.03447.x  PMID:12028041
• Yegneswaran, S., Fernandez, J. A., Griffin, J. H., Dawson, P. E. Factor Va increases the affinity of factor Xa for prothrombin: a binding study using a novel photoactivable thiol-specific fluorescent probe Chemistry & Biology  2002 9:485-494  DOI:10.1016/s1074-5521(02)00132-1  PMID:11983337
• Deguchi, H., Fernandez, J. A., Griffin, J. H. Neutral glycosphingolipid-dependent inactivation of coagulation factor Va by activated protein C and protein S Journal of Biological Chemistry  2002 277:8861-8865  DOI:10.1074/jbc.M110252200  PMID:11741960
• Petaja, J., Pesonen, E., Fernandez, J. A., Griffin, J. H., Repo, H., Jansson, S. E., Vento, A. E., Ramo, O. J. Activated protein C and inflammation in human myocardium after heart surgery American Journal of Hematology  2001 67:210-212  DOI:10.1002/ajh.1110  PMID:11391722
• Griffin, J. H., Fernandez, J. A., Deguchi, H. Plasma lipoproteins, hemostasis and thrombosis Thrombosis and Haemostasis  2001 86:386-394  PMID:11487028
• Shibata, M., Kumar, S. R., Amar, A., Fernandez, J. A., Hofman, F., Griffin, J. H., Zlokovic, B. V. Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke Circulation  2001 103:1799-1805  PMID:11282913
• Deguchi, H., Fernandez, J. A., Pabinger, I., Heit, J. A., Griffin, J. H. Plasma glucosylceramide deficiency as potential risk factor for venous thrombosis and modulator of anticoagulant protein C pathway Blood  2001 97:1907-1914  DOI:10.1182/blood.V97.7.1907  PMID:11264150
• Grody, W. W., Griffin, J. H., Taylor, A. K., Korf, B. R., Heit, J. A. American College of Medical Genetics consensus statement on factor V Leiden mutation testing Genetics in Medicine  2001 3:139-148  DOI:10.109700125817-200103000-00009  PMID:11280951  PMCID:PMC3111091
• Rintelen, C., Yegneswaran, S., Griffin, J. H. Anticoagulant dysfunction of human Arg352Trp-activated protein C caused by defective factor Va inactivation Thrombosis and Haemostasis  2001 85:274-279  PMID:11246547
• Hackeng, T. M., Fernandez, J. A., Dawson, P. E., Kent, S. B. H., Griffin, J. H. Chemical synthesis and spontaneous folding of a multidomain protein: anticoagulant microprotein S Proceedings of the National Academy of Sciences of the United States of America  2000 97:14074-14078  DOI:10.1073/pnas.260239797  PMID:11106381  PMCID:PMC18873
• Pellequer, J. L., Gale, A. J., Getzoff, E. D., Griffin, J. H. Three-dimensional model of coagulation factor Va bound to activated protein C Thrombosis and Haemostasis  2000 84:849-857  PMID:11127867
• Hackeng, T. M., Yegneswaran, S., Johnson, A. E., Griffin, J. H. Conformational changes in activated protein C caused by binding of the first epidermal growth factor-like module of protein S Biochemical Journal  2000 349:757-764  PMID:10903136  PMCID:PMC1221202
• Gale, A. J., Heeb, M. J., Griffin, J. H. The autolysis loop of activated protein C interacts with factor Va and differentiates between the Arg506 and Arg306 cleavage sites Blood  2000 96:585-593  PMID:10887122
• Mesters, R. M., Helterbrand, J., Utterback, B. G., Yan, S. B., Chao, Y. B., Fernandez, J. A., Griffin, J. H., Hartman, D. L. Prognostic value of protein C concentrations in neutropenic patients at high risk of severe septic complications Critical Care Medicine  2000 28:2209-2216  PMID:10921542
• Marx, P. F., Hackeng, T. M., Dawson, P. E., Griffin, J. H., Meijers, J. C. M., Bouma, B. N. Inactivation of active thrombin-activable fibrinolysis inhibitor takes place by a process that involves conformational instability rather than proteolytic cleavage Journal of Biological Chemistry  2000 275:12410-12415  DOI:10.1074/jbc.275.17.12410  PMID:10777524
• Fernandez, J. A., Kojima, K., Petaja, J., Hackeng, T. M., Griffin, J. H. Cardiolipin enhances protein C pathway anticoagulant activity Blood Cells Molecules and Diseases  2000 26:115-123  DOI:10.1006/bcmd.2000.0285  PMID:10753602
• Deguchi, H., Fernandez, J. A., Hackeng, T. M., Banka, C. L., Griffin, J. H. Cardiolipin is a normal component of human plasma lipoproteins Proceedings of the National Academy of Sciences of the United States of America  2000 97:1743-1748  DOI:10.1073/pnas.97.4.1743  PMID:10677528
• Griffin, J. H., Deguchi, H., Fernandez, J. A. Causes of thrombophilia yet to be discovered: A personal view Haemostasis  2000 30:26-33  PMID:11251338
• Griffin, J. H. Regulation of coagulation by the antithrombotic protein C pathway Archives of Hellenic Medicine  2000 17:19-25
• Gale, A. J., Pellequer, J. L., Getzoff, E. D., Griffin, J. H. Structural basis for hemophilia A caused by mutations in the C domains of blood coagulation factor VIII Thrombosis and Haemostasis  2000 83:78-85  PMID:10669159
• Heeb, M. J., Kojima, Y., Rosing, J., Tans, G., Griffin, J. H. C-terminal residues 621-635 of protein S are essential for binding to factor Va Journal of Biological Chemistry  1999 274:36187-36192  DOI:10.1074/jbc.274.51.36187  PMID:10593904
• Bouma, B. N., Mosnier, L. O., Meijers, J. C. M., Griffin, J. H. Factor XI dependent and independent activation of thrombin activatable fibrinolysis inhibitor (TAFI) in plasma associated with clot formation Thrombosis and Haemostasis  1999 82:1703-1708  PMID:10613658
• Fernandez, J. A., Petaja, J., Griffin, J. H. Dermatan sulfate and LMW heparin enhance the anticoagulant action of activated protein C Thrombosis and Haemostasis  1999 82:1462-1468  PMID:10595639
• Tabrizi, P., Wang, L., Seeds, N., McComb, J. G., Yamada, S., Griffin, J. H., Carmeliet, P., Weiss, M. H., Zlokovic, B. V. Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model - studies in tPA-deficient mice and wild-type mice on a matched genetic background Arteriosclerosis, Thrombosis, and Vascular Biology  1999 19:2801-2806  PMID:10559029
• Petaja, J., Pesonen, E., Fernandez, J. A., Vento, A. E., Ramo, O. J., Griffin, J. H. Cardiopulmonary bypass and activation of antithrombotic plasma protein C Journal of Thoracic and Cardiovascular Surgery  1999 118:422-429  DOI:10.1016/s0022-5223(99)70178-9  PMID:10469954
• Hackeng, T. M., Griffin, J. H., Dawson, P. E. Protein synthesis by native chemical ligation: expanded scope by using straightforward methodology Proceedings of the National Academy of Sciences of the United States of America  1999 96:10068-10073  DOI:10.1073/pnas.96.18.10068  PMID:10468563  PMCID:PMC17843
• Zivelin, A., Gitel, S., Griffin, J. H., Xu, X., Fernandez, J. A., Martinowitz, U., Cohen, Y., Halkin, H., Seligsohn, U., Inbal, A. Extensive venous and arterial thrombosis associated with an inhibitor to activated protein c Blood  1999 94:895-901  PMID:10419879
• Lentz, S. R., Fernandez, J. A., Griffin, J. H., Piegors, D. J., Erger, R. A., Malinow, M. R., Heistad, D. D. Impaired anticoagulant response to infusion of thrombin in atherosclerotic monkeys associated with acquired defects in the protein c system Arteriosclerosis, Thrombosis, and Vascular Biology  1999 19:1744-1750  PMID:10397693
• Xu, X., Bauer, K. A., Griffin, J. H. Two multiplex pcr-based DNA assays for the thrombosis risk factors prothrombin G20210A and coagulation factor V G1691A polymorphisms Thrombosis Research  1999 93:265-269  DOI:10.1016/s0049-3848(98)00178-9  PMID:10093967
• Macko, R. F., Killewich, L. A., Fernandez, J. A., Cox, D. K., Gruber, A., Griffin, J. H. Brain-specific protein C activation during carotid artery occlusion in humans Stroke  1999 30:542-545  PMID:10066849
• Griffin, J. H., Kojima, K., Banka, C. L., Curtiss, L. K., Fernandez, J. A. High-density lipoprotein enhancement of anticoagulant activities of plasma protein S and activated protein C Journal of Clinical Investigation  1999 103:219-227  DOI:10.1172/jci5006  PMID:9916134
• Pellequer, J. L., Gale, A. J., Griffin, J. H., Getzoff, E. D. Homology models of the C domains of blood coagulation factors V and VIII: A proposed membrane binding mode for FV and FVIII C2 domains Blood Cells Molecules and Diseases  1998 24:448-461  DOI:10.1006/bcmd.1998.0214  PMID:9880241
• Petaja, J., Fernandez, J. A., Fellman, V., Griffin, J. H. Upregulation of the antithrombotic protein C pathway at birth Pediatric Hematology and Oncology  1998 15:489-499  PMID:9842642
• Mounier, C. M., Hackeng, T. M., Schaeffer, F., Faure, G., Bon, C., Griffin, J. H. Inhibition of prothrombinase by human secretory phospholipase A2 involves binding to factor Xa Journal of Biological Chemistry  1998 273:23764-23772  DOI:10.1074/jbc.273.37.23764  PMID:9726985
• Hackeng, T. M., Dawson, P. E., Kent, S. B. H., Griffin, J. H. Chemical synthesis of human protein S thrombin-sensitive module and first epidermal growth factor module Biopolymers  1998 46:53-63  DOI:10.1002/(sici)1097-0282(199808)46:2<53::aid-bip1>3.3.co;2-6  PMID:9664841
• Kojima, Y., Heeb, M. J., Gale, A. J., Hackeng, T. M., Griffin, J. H. Binding site for blood coagulation factor Xa involving residues 311-325 in factor Va Journal of Biological Chemistry  1998 273:14900-14905  DOI:10.1074/jbc.273.24.14900  PMID:9614093
• Fernandez, J. A., Griffin, J. H., Chang, G. T. G., Stam, J., Reitsma, P. H., Bertina, R. M., Bouma, B. N. Involvement of amino acid residues 423-429 of human protein S in binding to C4b-binding protein Blood Cells Molecules and Diseases  1998 24:101-113  DOI:10.1006/bcmd.1998.0175  PMID:9628846
• Petaja, J., Hakala, L., Rasi, V., Griffin, J. H. Circulating activated protein C in subjects with heterozygous GIn506-factor V Haemostasis  1998 28:31-36  PMID:9885368
• Petaja, J. M., Griffin, J. H. Activated protein C resistance: What have we learned now that the dust has settled? Annals of Medicine  1997 29:469-472  DOI:10.3109/07853899709007469  PMID:9562511
• Wang, L. L., Zoppe, M., Hackeng, T. M., Griffin, J. H., Lee, K. F., Verma, I. M. A factor IX-deficient mouse model for hemophilia B gene therapy Proceedings of the National Academy of Sciences of the United States of America  1997 94:11563-11566  DOI:10.1073/pnas.94.21.11563  PMID:9326649
• Smiley, S. T., Boyer, S. N., Heeb, M. J., Griffin, J. H., Grusby, M. J. Protein S is inducible by interleukin 4 in T cells and inhibits lymphoid cell procoagulant activity Proceedings of the National Academy of Sciences of the United States of America  1997 94:11484-11489  DOI:10.1073/pnas.94.21.11484  PMID:9326636
• Fernandez, J. A., Petaja, J., Gruber, A., Griffin, J. H. Activated protein c correlates inversely with thrombin levels in resting healthy individuals American Journal of Hematology  1997 56:29-31  DOI:10.1002/(sici)1096-8652(199709)56:1<29::aid-ajh6>3.0.co;2-4  PMID:9298864
• Fernandez, J. A., Hackeng, T. M., Kojima, K., Griffin, J. H. The carbohydrate moiety of factor V modulates inactivation by activated protein C Blood  1997 89:4348-4354  PMID:9192757
• Petaja, J., Fernandez, J. A., Gruber, A., Griffin, J. H. Anticoagulant synergism of heparin and activated protein C in vitro - role of a novel anticoagulant mechanism of heparin, enhancement of inactivation of factor V by activated protein C Journal of Clinical Investigation  1997 99:2655-2663  DOI:10.1172/jci119454  PMID:9169495
• Tcheng, J. E., Lincoff, A. M., Sigmon, K. N., Lee, K. L., Kitt, M. M., Califf, R. M., Topol, E. J., Juran, N., Worley, S., Tuzi, J., Hollywood, L., Kleiman, N. S., et al. Randomised placebo-controlled trial of effect of eptifibatide on complications of percutaneous coronary intervention: IMPACT II Lancet  1997 349:1422-1428  PMID:9164315
• Fernandez, J. A., Heeb, M. J., Radtke, K. P., Griffin, J. H. Potent blood coagulant activity of human semen due to prostasome-bound tissue factor Biology of Reproduction  1997 56:757-763  DOI:10.1095/biolreprod56.3.757  PMID:9047022
• Zivelin, A., Griffin, J. H., Xu, X., Pabinger, I., Samama, M., Conard, J., Brenner, B., Eldor, A., Seligsohn, U. A single genetic origin for a common caucasian risk factor for venous thrombosis Blood  1997 89:397-402  PMID:9002940
• Gale, A. J., Sun, X., Heeb, M. J., Griffin, J. H. Nonenzymatic anticoagulant activity of the mutant serine protease Ser360Ala-activated protein C mediated by factor Va Protein Science  1997 6:132-140  DOI:PMC2143509  PMID:9007985
• Hackeng, T. M., Mounier, C. M., Bon, C., Dawson, P. E., Griffin, J. H., Kent, S. B. H. Total chemical synthesis of enzymatically active human type II secretory phospholipase A2 Proceedings of the National Academy of Sciences of the United States of America  1997 94:7845-7850  DOI:10.1073/pnas.94.15.7845  PMID:9223275  PMCID:PMC21517
• Macko, R. F., Ameriso, S. F., Gruber, A., Griffin, J. H., Fernandez, J. A., Barndt, R., Quismorio, F. P., Weiner, J. M., Fisher, M. Impairments of the protein C system and fibrinolysis in infection-associated stroke Stroke  1996 27:2005-2011  PMID:8898806
• Petaja, J., Lundstrom, U., Sairanen, H., Marttinen, E., Griffin, J. H. Central venous thrombosis after cardiac operations in children Journal of Thoracic and Cardiovascular Surgery  1996 112:883-889  DOI:10.1016/s0022-5223(96)70087-9  PMID:8873713
• Heeb, M. J., Kojima, Y., Hackeng, T. M., Griffin, J. H. Binding sites for blood coagulation factor Xa and protein S involving residues 493-506 in factor Va Protein Science  1996 5:1883-1889  DOI:10.1002/pro.5560050914  PMID:8880912  PMCID:PMC2143529
• Brenner, B., Zivelin, A., Lanir, N., Greengard, J. S., Griffin, J. H., Seligsohn, U. Venous thromboembolism associated with double heterozygosity for R506Q mutation of factor V and for T298M mutation of protein C in a large family of a previously described homozygous protein C-deficient newborn with massive thrombosis Blood  1996 88:877-880  PMID:8704244
• Fisher, M., Fernandez, J. A., Ameriso, S. F., Xie, D. C., Gruber, A., PaganiniHill, A., Griffin, J. H. Activated protein C resistance in ischemic stroke not due to factor V arginine(506)->glutamine mutation Stroke  1996 27:1163-1166  PMID:8685921
• Espana, F., SanchezCuenca, J., Estelles, A., Gilabert, J., Griffin, J. H., Heeb, M. J. Quantitative immunoassay for complexes of prostate-specific antigen with alpha(2)-macroglobulin Clinical Chemistry  1996 42:545-550  PMID:8605671
• Gillespie, D. L., Carringion, L. R., Griffin, J. H., Alving, B. M. Resistance to activated protein C: A common inherited cause of venous thrombosis Annals of Vascular Surgery  1996 10:174-177  DOI:10.1007/bf02000762  PMID:8733870
• Sifontes, M. T., Nuss, R., Jacobson, L. J., Griffin, J. H., MancoJohnson, M. J. Thrombosis in otherwise well children with the factor V leiden mutation Journal of Pediatrics  1996 128:324-328  DOI:10.1016/s0022-3476(96)70275-5  PMID:8774498
• Radtke, K. P., Greengard, J. S., Fernandez, J. A., Villoutreix, B. O., Griffin, J. H. A two-allele polymorphism in protein C inhibitor with varying frequencies in different ethnic populations Thrombosis and Haemostasis  1996 75:62-69  PMID:8713781
• Alving, B. M., Griffin, J. H. Laboratory evaluation and management of patients with venous thrombosis Consultant  1996 35:64-71
• Greengard, J. S., Xu, X., Gandrille, S., Griffin, J. H. Alternative PCR method for diagnosis of mutation causing activated protein-C resistant Gln(506)-factor-V Thrombosis Research  1995 80:441-443  DOI:10.1016/0049-3848(95)00197-y  PMID:8588206
• Villoutreix, B. O., Fernandez, J. A., Teleman, O., Griffin, J. H. Comparative modeling of the three CP modules of the beta-chain of C4BP and evaluation of potential sites of interaction with protein S Protein Engineering  1995 8:1253-1258  DOI:10.1093/protein/8.12.1253  PMID:8869637
• Griffin, J. H. Blood coagulation. The thrombin paradox Nature  1995 378:337-338  DOI:10.1038/378337a0  PMID:7477366
• Heeb, M. J., Espana, F., Gittes, R. F., Griffin, J. H. Prostate specific antigen-alpha(2)-macroglobulin complexes in prostate cancer patient sera Biochemistry and Molecular Biology International  1995 37:917-923  PMID:8624498
• Spek, C. A., Greengard, J. S., Griffin, J. H., Bertina, R. M., Reitsma, P. H. Two mutations in the promoter region of the human protein-C gene both cause type-I protein-C deficiency by disruption of 2 HNF-3 binding-sites Journal of Biological Chemistry  1995 270:24216-24221  PMID:7592627
• Radtke, K. P., Fernandez, J. A., Villoutreix, B. O., Greengard, J. S., Griffin, J. H. Characterization of a cDNA for rhesus-monkey protein-C inhibitor - evidence for N-terminal involvement in heparin stimulation Thrombosis and Haemostasis  1995 74:1079-1087  PMID:8560417
• Gandrille, S., Greengard, J. S., Alhencgelas, M., Juhanvague, I., Abgrall, J. F., Jude, B., Griffin, J. H., Aiach, M. Incidence of activated protein-C resistance caused by the ARG-506 GLN mutation in factor-V in 113 unrelated symptomatic protein C-deficient patients Blood  1995 86:219-224  PMID:7795227
• Heeb, M. J., Kojima, Y., Greengard, J. S., Griffin, J. H. Activated protein C resistance: molecular mechanisms based on studies using purified Gln506-factor V Blood  1995 85:3405-3411  PMID:7780127
• Le, D. T., Griffin, J. H., Greengard, J. S., Mujumdar, V., Rapaport, S. I. Use of a generally applicable tissue factor-dependent factor-v assay to detect activated protein c-resistant factor va in patients receiving warfarin and in patients with a lupus anticoagulant Blood  1995 85:1704-1711  PMID:7703480
• Greengard, J. S., Fernandez, J. A., Radtke, K. P., Griffin, J. H. Identification of candidate residues for interaction of protein-S with C4b binding-protein and activated protein-C Biochemical Journal  1995 305:397-403  PMID:7832752  PMCID:PMC1136375
• Griffin, J. H., Heeb, M. J., Kojima, Y., Fernandez, J. A., Kojima, K., Hackeng, T. M., Greengard, J. S. Activated protein C resistance: molecular mechanisms Thrombosis and Haemostasis  1995 74:444-448  PMID:8578503
• Calkins, T., Greengard, J., Griffin, J. H., Bylund, D. Anticoagulant response to activated protein-C- method validation and assay comparison Journal of Clinical Laboratory Analysis  1995 9:418-423  DOI:10.1002/jcla.1860090614  PMID:8587012
• Greengard, J. S., Eichinger, S., Griffin, J. H., Bauer, K. A. Variability of thrombosis among homozygous siblings with resistance to activated protein-C due to an Arg- Gln mutation in the gene for factor-V New England Journal of Medicine  1994 331:1559-1562  DOI:10.1056/nejm199412083312305  PMID:7969326
• Greengard, J. S., Griffin, J. H., Fisher, C. L. Possible structural implications of 20 mutations in the protein-C protease domain Thrombosis and Haemostasis  1994 72:869-873  PMID:7740456
• Villoutreix, B. O., Getzoff, E. D., Griffin, J. H. A structural model for the prostate disease marker, human prostate-specific antigen Protein Science  1994 3:2033-2044  DOI:10.1002/pro.5560031116  PMID:7535613  PMCID:PMC2142655
• Radtke, K. P., Fernandez, J. A., Greengard, J. S., Tang, W. W., Wilson, C. B., Loskutoff, D. J., Scharrer, I., Griffin, J. H. Protein C inhibitor is expressed in tubular cells of human kidney Journal of Clinical Investigation  1994 94:2117-2124  DOI:10.1172/jci117566  PMID:7525654  PMCID:PMC294656
• Fernandez, J. A., Villoutreix, B. O., Hackeng, T. M., Griffin, J. H., Bouma, B. N. Analysis of protein-S C4b-binding protein interactions by homology modeling and inhibitory antibodies Biochemistry  1994 33:11073-11078  DOI:10.1021/bi00203a003  PMID:7727359
• Tsay, W., Greengard, J. S., Griffin, J. H. Exonic polymorphisms in the protein-C gene - interethnic comparison between caucasians and asians Human Genetics  1994 94:177-178  PMID:8045564
• Sun, X., Evatt, B., Griffin, J. H. Blood-coagulation factor Va abnormality associated with resistance to activated protein-C in venous thrombophilia Blood  1994 83:3120-3125  PMID:8193349
• Greengard, J. S., Sun, X., Xu, X., Fernandez, J. A., Griffin, J. H., Evatt, B. Activated protein C resistance caused by Arg506Gln mutation in factor Va Lancet  1994 343:1361-1362  DOI:10.1016/s0140-6736(94)92497-x  PMID:7910348
• Gruber, A., Mori, E., del Zoppo, G. J., Waxman, L., Griffin, J. H. Alteration of fibrin network by activated protein-C Blood  1994 83:2541-2548  PMID:8167339
• Fisher, C. L., Greengard, J. S., Griffin, J. H. Models of the serine-protease domain of the human antithrombotic plasma factor-activated protein-C and its zymogen Protein Science  1994 3:588-599  DOI:10.1002/pro.5560030407  PMID:8003977  PMCID:PMC2142866
• Greengard, J. S., Fisher, C. L., Villoutreix, B., Griffin, J. H. Structural basis for type-I and type-II deficiencies of antithrombotic plasma protein-C - patterns revealed by 3-dimensional molecular modeling of mutations of the protease domain Proteins-Structure Function and Genetics  1994 18:367-380  DOI:10.1002/prot.340180407  PMID:8208728
• Heeb, M. J., Rosing, J., Bakker, H. M., Fernandez, J. A., Tans, G., Griffin, J. H. Protein-S binds to and inhibits factor-Xa Proceedings of the National Academy of Sciences of the United States of America  1994 91:2728-2732  DOI:10.1073/pnas.91.7.2728  PMID:8146182
• Fernandez, J. A., Griffin, J. H. A protein-S binding-site on C4b-binding protein involves beta-chain residues 31-45 Journal of Biological Chemistry  1994 269:2535-2540  PMID:8300581
• Espana, F., Estelles, A., Fernandez, P. J., Gilabert, J., Sanchezcuenca, J., Griffin, J. H. Evidence for the regulation of urokinase and tissue-type plasminogen activators by the serpin, protein-C inhibitor, in semen and blood-plasma Thrombosis and Haemostasis  1993 70:989-994  PMID:8165623
• Mesters, R. M., Heeb, M. J., Griffin, J. H. A novel exosite in the light chain of human activated protein C essential for interaction with blood coagulation factor Va Biochemistry  1993 32:12656-12663  DOI:10.1021/bi00210a014  PMID:8251484
• Gruber, A., Pal, A., Kiss, R. G., Sas, G., Griffin, J. H. Generation of activated protein-C during thrombolysis Lancet  1993 342:1275-1276  DOI:10.1016/0140-6736(93)92364-y  PMID:7901587
• Griffin, J. H., Evatt, B., Wideman, C., Fernandez, J. A. Anticoagulant protein-C pathway defective in majority of thrombophilic patients Blood  1993 82:1989-1993  PMID:8400251
• Hanson, S. R., Griffin, J. H., Harker, L. A., Kelly, A. B., Esmon, C. T., Gruber, A. Antithrombotic effects of thrombin-induced activation of endogenous protein-C in primates Journal of Clinical Investigation  1993 92:2003-2012  DOI:10.1172/jci116795  PMID:8408654
• Tsay, W., Greengard, J. S., Montgomery, R. R., McPherson, R. A., Fucci, J. C., Koerper, M. A., Coughlin, J., Griffin, J. H. Genetic mutations in ten unrelated american patients with symptomatic type-1 protein-C deficiency Blood Coagulation & Fibrinolysis  1993 4:791-796  DOI:10.1097/00001721-199304050-00017  PMID:8292730
• Mesters, R. M., Heeb, M. J., Griffin, J. H. Interactions and inhibition of blood-coagulation factor-Va involving residues 311-325 of activated protein-C Protein Science  1993 2:1482-1489  DOI:10.1002/pro.5560020912  PMID:8401232  PMCID:PMC2142455
• Conard, J., Bauer, K. A., Gruber, A., Griffin, J. H., Schwarz, H. P., Horellou, M. H., Samama, M. M., Rosenberg, R. D. Normalization of markers of coagulation activation with a purified protein-C concentrate in adults with homozygous protein-C deficiency Blood  1993 82:1159-1164  PMID:8353282
• Fernandez, J. A., Heeb, M. J., Griffin, J. H. Identification of residues 413-433 of plasma protein S as essential for binding to C4b-binding protein Journal of Biological Chemistry  1993 268:16788-16794  PMID:7688369
• Phillips, D. J., Greengard, J. S., Fernandez, J. A., Ribeiro, M., Evatt, B. L., Griffin, J. H., Hooper, W. C. Protein-S, an antithrombotic factor, is synthesized and released by neural tumor-cells Journal of Neurochemistry  1993 61:344-347  DOI:10.1111/j.1471-4159.1993.tb03574.x  PMID:8515282
• Heeb, M. J., Mesters, R. M., Tans, G., Rosing, J., Griffin, J. H. Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C Journal of Biological Chemistry  1993 268:2872-2877  PMID:8428962
• Berrettini, M., Schleef, R. R., Heeb, M. J., Hopmeier, P., Griffin, J. H. Assembly and expression of an intrinsic factor-IX activator complex on the surface of cultured human endothelial-cells Journal of Biological Chemistry  1992 267:19833-19839  PMID:1400299
• Bakker, H. M., Tans, G., Janssenclaessen, T., Thomassen, Mclgd, Hemker, H. C., Griffin, J. H., Rosing, J. The effect of phospholipids, calcium-ions and protein-S on rate constants of human factor-Va inactivation by activated human protein-C European Journal of Biochemistry  1992 208:171-178  DOI:10.1111/j.1432-1033.1992.tb17171.x  PMID:1387359
• Griffin, J. H., Gruber, A., Fernandez, J. A. Reevaluation of total, free, and bound protein-S and C4b-binding protein-levels in plasma anticoagulated with citrate or hirudin Blood  1992 79:3203-3211  PMID:1534488
• Gruber, A., Griffin, J. H. Direct detection of activated protein-C in blood from human-subjects Blood  1992 79:2340-2348  PMID:1571547
• Greengard, J. S., Griffin, J. H. High-molecular-weight kininogen receptor Methods in Enzymology  1992 215:369-382  PMID:1331710
• Mesters, R. M., Houghten, R. A., Griffin, J. H. Identification of a sequence of human activated protein-C (residues 390-404) essential for its anticoagulant activity Journal of Biological Chemistry  1991 266:24514-24519  PMID:1761551
• Gruber, A., Harker, L. A., Hanson, S. R., Kelly, A. B., Griffin, J. H. Antithrombotic effects of combining activated protein-C and urokinase in nonhuman-primates Circulation  1991 84:2454-2462  PMID:1835678
• Heeb, M. J., Gruber, A., Griffin, J. H. Identification of divalent metal ion-dependent inhibition of activated protein-C by alpha-2-macroglobulin and alpha-2-antiplasmin in blood and comparisons to inhibition of factor-Xa, thrombin, and plasmin Journal of Biological Chemistry  1991 266:17606-17612  PMID:1716632
• Vicente, V., Espana, F., Tabernero, D., Estelles, A., Aznar, J., Hendl, S., Griffin, J. H. Evidence of activation of the protein-c pathway during acute vascular damage induced by mediterranean spotted-fever Blood  1991 78:416-422  PMID:1648982
• Geiger, M., Priglinger, U., Griffin, J. H., Binder, B. R. Urinary protein-C inhibitor - glycosaminoglycans synthesized by the epithelial kidney-cell line TCL-598 enhance its interaction with urokinase Journal of Biological Chemistry  1991 266:11851-11857  PMID:1646816
• Tans, G., Rosing, J., Christella, M., Thomassen, L. G. D., Heeb, M. J., Zwaal, R. F. A., Griffin, J. H. Comparison of anticoagulant and procoagulant activities of stimulated platelets and platelet-derived microparticles Blood  1991 77:2641-2648  PMID:2043766
• Espana, F., Gilabert, J., Aznar, J., Estelles, A., Kobayashi, T., Griffin, J. H. Complexes of activated protein-C with alpha-1-antitrypsin in normal-pregnancy and in severe preeclampsia American Journal of Obstetrics and Gynecology  1991 164:1310-1316  PMID:1852102
• Espana, F., Estelles, A., Griffin, J. H., Aznar, J. Interaction of plasma kallikrein with protein-C inhibitor in purified mixtures and in plasma Thrombosis and Haemostasis  1991 65:46-51  PMID:1850876
• Hendl, S., Espana, F., Aznar, J., Estelles, A., Gilabert, J., Griffin, J. H. Immunoaffinity purification of protein C with a calcium-dependent monoclonal antibody Revista Iberoamericana de Trombosis y Hemostasia  1991 4:25-28
• Espana, F., Gruber, A., Heeb, M. J., Hanson, S. R., Harker, L. A., Griffin, J. H. In vivo and in vitro complexes of activated protein C with two inhibitors in baboons Blood  1991 77:1754-1760  PMID:1849759
• Kuhn, L. A., Griffin, J. H., Fisher, C. L., Greengard, J. S., Bouma, B. N., Espana, F., Tainer, J. A. Elucidating the structural chemistry of glycosaminoglycan recognition by protein-C inhibitor Proceedings of the National Academy of Sciences of the United States of America  1990 87:8506-8510  DOI:10.1073/pnas.87.21.8506  PMID:2172989
• Espana, F., Vicente, V., Tabernero, D., Scharrer, I., Griffin, J. H. Determination of plasma protein-C inhibitor and of 2 activated protein-C-inhibitor complexes in normals and in patients with intravascular coagulation and thrombotic disease Thrombosis Research  1990 59:593-608  DOI:10.1016/0049-3848(90)90418-c  PMID:2173167
• Gruber, A., Hanson, S. R., Kelly, A. B., Yan, B. S., Bang, N., Griffin, J. H., Harker, L. A. Inhibition of thrombus formation by activated recombinant protein-C in a primate model of arterial thrombosis Circulation  1990 82:578-585  PMID:2372904
• Heeb, M. J., Bischoff, R., Courtney, M., Griffin, J. H. Inhibition of activated protein C by recombinant alpha 1-antitrypsin variants with substitution of arginine or leucine for methionine-358 Journal of Biological Chemistry  1990 265:2365-2369  PMID:2298753
• Espana, F., Estelles, A., Griffin, J. H., Aznar, J., Gilabert, J. Aprotinin (trasylol) is a competitive inhibitor of activated protein-C Thrombosis Research  1989 56:751-756  DOI:10.1016/0049-3848(89)90292-2  PMID:2483763
• Espana, F., Griffin, J. H. Determination of functional and antigenic protein-C inhibitor and its complexes with activated protein-C in plasma by ELISA's Thrombosis Research  1989 55:671-682  DOI:10.1016/0049-3848(89)90298-3  PMID:2551066
• Geiger, M., Huber, K., Wojta, J., Stingl, L., Espana, F., Griffin, J. H., Binder, B. R. Complex formation between urokinase and plasma protein C inhibitor in vitro and in vivo Blood  1989 74:722-728  PMID:2752144
• Espana, F., Berrettini, M., Griffin, J. H. Purification and characterization of plasma protein-c inhibitor Thrombosis Research  1989 55:369-384  DOI:10.1016/0049-3848(89)90069-8  PMID:2551064
• Berrettini, M., Schleef, R. R., Espana, F., Loskutoff, D. J., Griffin, J. H. Interaction of type 1 plasminogen activator inhibitor with the enzymes of the contact activation system Journal of Biological Chemistry  1989 264:11738-11743  PMID:2787318
• Gladson, C. L., Schleef, R. R., Binder, B. R., Loskutoff, D. J., Griffin, J. H. A comparison between activated protein C and des-1-41-light chain-activated protein C in reactions with type 1 plasminogen activator inhibitor Blood  1989 74:173-181  PMID:2787675
• Schwarz, H. P., Heeb, M. J., Lottenberg, R., Roberts, H., Griffin, J. H. Familial protein S deficiency with a variant protein S molecule in plasma and platelets Blood  1989 74:213-221  PMID:2526663
• Geiger, M., White, T. M., Griffin, J. H. Functional assays for protein-C activity and protein-C inhibitor activity in plasma Thrombosis and Haemostasis  1989 61:86-92  PMID:2546280
• Gruber, A., Griffin, J. H., Harker, L. A., Hanson, S. R. Inhibition of platelet-dependent thrombus formation by human activated protein-C in a primate model Blood  1989 73:639-642  PMID:2917194
• Heeb, M. J., Mosher, D., Griffin, J. H. Activation and complexation of protein C and cleavage and decrease of protein S in plasma of patients with intravascular coagulation Blood  1989 73:455-461  PMID:2521800
• Heeb, M. J., Espana, F., Griffin, J. H. Inhibition and complexation of activated protein C by two major inhibitors in plasma Blood  1989 73:446-454  PMID:2917184
• Heeb, M. J., Schwarz, H. P., White, T., Lammle, B., Berrettini, M., Griffin, J. H. Immunoblotting studies of the molecular forms of protein C in plasma Thrombosis Research  1988 52:33-43  DOI:10.1016/0049-3848(88)90038-2  PMID:3201394
• Heeb, M. J., Griffin, J. H. Physiologic inhibition of human activated protein-C by alpha-1-antitrypsin Journal of Biological Chemistry  1988 263:11613-11616  PMID:3261294
• Lammle, B., Zuraw, B. L., Heeb, M. J., Schwarz, H. P., Berrettini, M., Curd, J. G., Griffin, J. H. Detection and quantitation of cleaved and uncleaved high molecular weight kininogen in plasma by ligand blotting with radiolabeled plasma prekallikrein or factor XI Thrombosis and Haemostasis  1988 59:151-161  PMID:3388291
• Geiger, M., Heeb, M. J., Binder, B. R., Griffin, J. H. Competition of activated protein-C and urokinase for a heparin-dependent inhibitor FASEB Journal  1988 2:2263-2267  PMID:3350241
• Schwarz, H. P., Muntean, W., Watzke, H., Richter, B., Griffin, J. H. Low total protein-S antigen but high protein-S activity due to decreased C4b-binding protein in neonates Blood  1988 71:562-565  PMID:2964259
• Alter, S. C., Lammle, B., Griffin, J. H., Schwartz, L. B. Tryptase from human mast-cells does not activate purified human Hageman-factor Clinical Allergy  1988 18:151-156  DOI:10.1111/j.1365-2222.1988.tb02854.x  PMID:3284668
• Gladson, C. L., Scharrer, I., Hach, V., Beck, K. H., Griffin, J. H. The frequency of type-I heterozygous protein-S and protein-C deficiency in 141 unrelated young-patients with venous thrombosis Thrombosis and Haemostasis  1988 59:18-22  PMID:2966450
• Sakata, Y., Griffin, J. H., Loskutoff, D. J. Effect of activated protein C on the fibrinolytic components released by cultured bovine aortic endothelial cells Fibrinolysis  1988 2:7-15  DOI:10.1016/0268-9499(88)90059-8
• Tans, G., Verkleij, A. J., Yu, J., Griffin, J. H. Sulfatide bilayers as a surface for contact activation in human plasma Biochemical and Biophysical Research Communications  1987 149:1002-1007  DOI:10.1016/0006-291x(87)90508-0  PMID:3426605
• Gladson, C. L., Groncy, P., Griffin, J. H. Coumarin necrosis, neonatal purpura fulminans, and protein C deficiency Archives of Dermatology  1987 123:1701a-1706a  PMID:2961308
• Heeb, M. J., Espana, F., Geiger, M., Collen, D., Stump, D. C., Griffin, J. H. Immunological identity of heparin-dependent plasma and urinary protein C inhibitor and plasminogen activator inhibitor-3 Journal of Biological Chemistry  1987 262:15813-15816  PMID:2824468
• Tans, G., Rosing, J., Berrettini, M., Lammle, B., Griffin, J. H. Autoactivation of human-plasma prekallikrein Journal of Biological Chemistry  1987 262:11308-11314  PMID:2440889
• Tans, G., Janssenclaessen, T., Rosing, J., Griffin, J. H. Studies on the effect of serine protease inhibitors on activated contact factors - application in amidolytic assays for factor-XIIa, plasma kallikrein and factor-XIa European Journal of Biochemistry  1987 164:637-642  DOI:10.1111/j.1432-1033.1987.tb11174.x  PMID:3552674
• Schwarz, H. P., Schernthaner, G., Griffin, J. H. Decreased plasma levels of protein S in well-controlled type I diabetes mellitus Thrombosis and Haemostasis  1987 57:240  PMID:2955541
• Lammle, B., Berrettini, M., Griffin, J. H. Immunoblotting studies of coagulation factor-XII, plasma prekallikrein, and high-molecular-weight kininogen Seminars in Thrombosis and Hemostasis  1987 13:106-114  DOI:10.1055/s-2007-1003480  PMID:3494310
• Griffin, J. H., Heeb, M. J., Schwarz, H. P. Plasma protein S deficiency and thromboembolic disease Progress in Hematology  1987 15:39-49  PMID:2971986
• Schwarz, H. P., Heeb, M. J., Lammle, B., Berrettini, M., Griffin, J. H. Quantitative immunoblotting of plasma and platelet protein S Thrombosis and Haemostasis  1986 56:382-386  PMID:2436335
• Sakata, Y., Loskutoff, D. J., Gladson, C. L., Hekman, C. M., Griffin, J. H. Mechanism of protein C-dependent clot lysis: role of plasminogen activator inhibitor Blood  1986 68:1218-1223  PMID:3096399
• Cembrowski, G. S., Griffin, J. H., Mosher, D. F. Diagnostic efficacy of 6 plasma-proteins in evaluating consumptive coagulopathies - use of receiver operating characteristic curves to compare antithrombin-III, plasminogen, alpha-2-plasmin inhibitor, fibronectin, prothrombin, and protein-C Archives of Internal Medicine  1986 146:1997-2002  DOI:10.1001/archinte.146.10.1997  PMID:3767544
• Berrettini, M., Lammle, B., White, T., Heeb, M. J., Schwarz, H. P., Zuraw, B., Curd, J., Griffin, J. H. Detection of in vitro and in vivo cleavage of high molecular weight kininogen in human plasma by immunoblotting with monoclonal antibodies Blood  1986 68:455-462  PMID:3730610
• Greengard, J. S., Heeb, M. J., Ersdal, E., Walsh, P. N., Griffin, J. H. Binding of coagulation factor-XI to washed human-platelets Biochemistry  1986 25:3884-3890  DOI:10.1021/bi00361a022  PMID:3017409
• Bouma, B. N., Kerbiriou, D. M., Baker, J., Griffin, J. H. Characterization of a variant prekallikrein, prekallikrein Long-Beach, from a family with mixed cross-reacting material positive and cross-reacting material negative prekallikrein deficiency Journal of Clinical Investigation  1986 78:170-176  DOI:10.1172/jci112547  PMID:3487556
• Lammle, B., Berrettini, M., Griffin, J. H. Enhanced specificity of immunoblotting using radiolabeled antigen overlay - studies of blood-coagulation factor-XII and prekallikrein in plasma Analytical Biochemistry  1986 156:118-125  DOI:10.1016/0003-2697(86)90162-4  PMID:3638135
• Podack, E. R., Dahlback, B., Griffin, J. H. Interaction of S-protein of complement with thrombin and antithrombin-III during coagulation - protection of thrombin by S-protein from antithrombin-III inactivation Journal of Biological Chemistry  1986 261:7387-7392  PMID:3754869
• Bezeaud, A., Drouet, L., Leverger, G., Griffin, J. H., Guillin, M. C. Effect of L-asparaginase therapy for acute lymphoblastic-leukemia on plasma vitamin-K-dependent coagulation-factors and inhibitors Journal of Pediatrics  1986 108:698-701  DOI:10.1016/s0022-3476(86)81044-7  PMID:2939229
• Lammle, B., Berrettini, M., Schwarz, H. P., Heeb, M. J., Griffin, J. H. Quantitative immunoblotting assay of blood-coagulation factor-XII Thrombosis Research  1986 41:747-759  DOI:10.1016/0049-3848(86)90373-7  PMID:3085274
• Sas, G., Blasko, G., Petro, I., Griffin, J. H. A protein S deficient family with portal vein thrombosis Thrombosis and Haemostasis  1985 54:724  PMID:2935967
• Sakata, Y., Curriden, S., Lawrence, D., Griffin, J. H., Loskutoff, D. J. Activated protein C stimulates the fibrinolytic activity of cultured endothelial cells and decreases antiactivator activity Proceedings of the National Academy of Sciences of the United States of America  1985 82:1121-1125  DOI:10.1073/pnas.82.4.1121  PMID:3871946  PMCID:PMC397206
• Lammle, B., Griffin, J. H. Formation of the fibrin clot: the balance of procoagulant and inhibitory factors Clinics in Haematology  1985 14:281-342  PMID:2994929
• Schwarz, H. P., Heeb, M. J., Wenceldrake, J. D., Griffin, J. H. Identification and quantitation of protein-S in human-platelets Blood  1985 66:1452-1455  PMID:2933098
• Cosio, F. G., Harker, C., Batard, M. A., Brandt, J. T., Griffin, J. H. Plasma-concentrations of the natural anticoagulants protein-C and protein-S in patients with proteinuria Journal of Laboratory and Clinical Medicine  1985 106:218-222  PMID:3160800
• Bock, P. E., Shore, J. D., Tans, G., Griffin, J. H. Protein-protein interactions in contact activation of blood-coagulation - binding of high molecular-weight kininogen and the 5-(iodoacetamido)fluorescein-labeled kininogen light chain to prekallikrein, kallikrein, and the separated kallikrein heavy and light-chains Journal of Biological Chemistry  1985 260:2434-2443
• Rosing, J., Tans, G., Griffin, J. H. Surface-dependent activation of human factor-XII (Hageman-factor) by kallikrein and its light chain European Journal of Biochemistry  1985 151:531-538  DOI:10.1111/j.1432-1033.1985.tb09135.x  PMID:3875484
• Schwartz, L. B., Bradford, T., Griffin, J. H. The effect of tryptase from human mast-cells on human prekallikrein Biochemical and Biophysical Research Communications  1985 129:76-81  DOI:10.1016/0006-291x(85)91405-6  PMID:3890857
• Griffin, J. H. Clinical-studies of protein-C Seminars in Thrombosis and Hemostasis  1984 10:162-166  DOI:10.1055/s-2007-1004419  PMID:6377499
• Schwarz, H. P., Fischer, M., Hopmeier, P., Batard, M. A., Griffin, J. H. Plasma protein-S deficiency in familial thrombotic disease Blood  1984 64:1297-1300  PMID:6238642
• Fulcher, C. A., Gardiner, J. E., Griffin, J. H., Zimmerman, T. S. Proteolytic inactivation of human factor-VIII procoagulant protein by activated human protein-C and its analogy with factor-V Blood  1984 63:486-489  PMID:6419799
• Greengard, J. S., Griffin, J. H. Receptors for high molecular-weight kininogen on stimulated washed human-platelets Biochemistry  1984 23:6863-6869  DOI:10.1021/bi00321a090  PMID:6099145
• Griffin, J. H., Bezeaud, A., Evatt, B., Mosher, D. Studies of protein-C in thromboembolic disease Ricerca in Clinica e in Laboratorio  1984 14:469-473  PMID:6395293
• Gardiner, J. E., Griffin, J. H. Studies on human protein-C inhibitor in normal and factor-V/VIII deficient plasmas Thrombosis Research  1984 36:197-203  DOI:10.1016/0049-3848(84)90219-6  PMID:6549082
• Walsh, P. N., Tuszynski, G. P., Greengard, J. S., Griffin, J. H. The possible role of platelets in bypassing the contact phase of blood coagulation Haematologia  1984 17:169-178  PMID:6534825
• Miles, L. A., Greengard, J. S., Griffin, J. H. A comparison of the abilities of plasma kallikrein, beta-Factor XIIa, Factor XIa and urokinase to activate plasminogen Thrombosis Research  1983 29:407-417  DOI:10.1016/0049-3848(83)90244-x  PMID:6344314
• Miles, L. A., Rothschild, Z., Griffin, J. H. Dextran sulfate-dependent fibrinolysis in whole human plasma. Journal of Laboratory and Clinical Medicine  1983 101:214-225  PMID:6185600
• Miles, L. A., Rothschild, Z., Griffin, J. H. Dextran sulfate-dependent fibrinolytic activity in whole human plasma Progress in Fibrinolysis  1983 6:58-61
• Gardiner, J. E., Griffin, J. H. Human protein-C and thromboembolic disease Progress in Hematology  1983 13:265-278  PMID:6422505
• Bouma, B. N., Vlooswijk, R. A. A., Griffin, J. H. Immunological studies of human coagulation factor-XI and its complex with high molecular-weight kininogen Blood  1983 62:1123-1131  PMID:6626744
• Branson, H. E., Marble, R., Katz, J., Griffin, J. H. Inherited protein-C deficiency and coumarin-responsive chronic relapsing purpura fulminans in a newborn-infant Lancet  1983 2:1165-1168  PMID:6139528
• Vandergraaf, F., Koedam, J. A., Griffin, J. H., Bouma, B. N. Interaction of human-plasma kallikrein and its light chain with C1 inhibitor Biochemistry  1983 22:4860-4866  DOI:10.1021/bi00289a037  PMID:6556071
• Vandergraaf, F., Greengard, J. S., Bouma, B. N., Kerbiriou, D. M., Griffin, J. H. Isolation and functional-characterization of the active light chain of activated human-blood coagulation factor-XI Journal of Biological Chemistry  1983 258:9669-9675  PMID:6604052
• Tans, G., Rosing, J., Griffin, J. H. Sulfatide-dependent autoactivation of human-blood coagulation Factor-XII (Hageman-factor) Journal of Biological Chemistry  1983 258:8215-8222  PMID:6553053
• Miles, L. A., Plow, E. F., Donnelly, K. J., Hougie, C., Griffin, J. H. A bleeding disorder due to deficiency of alpha-2-antiplasmin Blood  1982 59:1246-1251  PMID:7082827
• Marlar, R. A., Kleiss, A. J., Griffin, J. H. An alternative extrinsic pathway of human-blood coagulation Blood  1982 60:1353-1358  PMID:7139124
• Vandergraaf, F., Tans, G., Bouma, B. N., Griffin, J. H. Isolation and functional-properties of the heavy and light-chains of human-plasma kallikrein Journal of Biological Chemistry  1982 257:4300-4305  PMID:6815193
• Marlar, R. A., Kleiss, A. J., Griffin, J. H. Mechanism of action of human activated protein-C, a thrombin-dependent anticoagulant enzyme Blood  1982 59:1067-1072  PMID:6803853
• Tans, G., Griffin, J. H. Properties of sulfatides in factor-XII-dependent contact activation Blood  1982 59:69-75  PMID:6914902
• Griffin, J. H., Mosher, D. F., Zimmerman, T. S., Kleiss, A. J. Protein-C, an antithrombotic protein, is reduced in hospitalized-patients with intravascular coagulation Blood  1982 60:261-264  PMID:6896290
• Cochrane, C. G., Griffin, J. H. The biochemistry and pathophysiology of the contact system of plasma Advances in Immunology  1982 33:241-306  DOI:10.1016/s0065-2776(08)60837-8  PMID:6182767
• Walsh, P. N., Griffin, J. H. Contributions of human-platelets to the proteolytic activation of blood-coagulation factor-XII and factor-XI Blood  1981 57:106-118  PMID:7004531
• Griffin, J. H., Evatt, B., Zimmerman, T. S., Kleiss, A. J., Wideman, C. Deficiency of protein-C in congenital thrombotic disease Journal of Clinical Investigation  1981 68:1370-1373  DOI:10.1172/jci110385  PMID:6895379
• Miles, L. A., Burnier, J. P., Verlander, M. S., Goodman, M., Kleiss, A. J., Griffin, J. H. Inactivation of purified human alpha 2-antiplasmin and purified human C1 inhibitor by synthetic fibrinolytic agents Blood  1981 57:1015-1024  PMID:6452920
• Curd, J. G., Yelvington, M., Ziccardi, R. J., Mathison, D. A., Griffin, J. H. Purification and characterization of 2 functionally distinct forms of C-1 inhibitor from a patient with angioedema Clinical and Experimental Immunology  1981 45:261-270  PMID:6976242  PMCID:PMC1537389
• Wiggins, R. C., Loskutoff, D. J., Cochrane, C. G., Griffin, J. H., Edgington, T. S. Activation of rabbit Hageman factor by homogenates of cultured rabbit endothelial cells Journal of Clinical Investigation  1980 65:197-206  DOI:10.1172/jci109651  PMID:6444222  PMCID:PMC371355
• Marlar, R. A., Griffin, J. H. Deficiency of protein-C inhibitor in combined factor-V-VIII deficiency disease Journal of Clinical Investigation  1980 66:1186-1189  DOI:10.1172/jci109952  PMID:6253526
• Bouma, B. N., Miles, L. A., Beretta, G., Griffin, J. H. Human plasma prekallikrein. Studies of its activation by activated factor XII and of its inactivation by diisopropyl phosphofluoridate Biochemistry  1980 19:1151-1160  DOI:10.1021/bi00547a018  PMID:6768384
• Kerbiriou, D. M., Bouma, B. N., Griffin, J. H. Immunochemical studies of human high molecular-weight kininogen and of its complexes with plasma prekallikrein or kallikrein Journal of Biological Chemistry  1980 255:3952-3958  PMID:6154706
• Bouma, B. N., Kerbiriou, D. M., Vlooswijk, R. A. A., Griffin, J. H. Immunological studies of prekallikrein, kallikrein, and high-molecular-weight kininogen in normal and deficient plasmas and in normal plasma after cold-dependent activation Journal of Laboratory and Clinical Medicine  1980 96:693-709  PMID:6903191
• Ginsberg, M. H., Jaques, B., Cochrane, C. G., Griffin, J. H. Urate crystal--dependent cleavage of Hageman factor in human plasma and synovial fluid Journal of Laboratory and Clinical Medicine  1980 95:497-506  PMID:6898641
• Seligsohn, U., Osterud, B., Brown, S. F., Griffin, J. H., Rapaport, S. I. Activation of human factor-VII in plasma and in purified systems - roles of activated factor-IX, kallikrein, and activated factor-XII Journal of Clinical Investigation  1979 64:1056-1065  DOI:10.1172/jci109543  PMID:479368
• Kerbiriou, D. M., Griffin, J. H. Human high molecular-weight kininogen - studies of structure-function-relationships and of proteolysis of the molecule occurring during contact activation of plasma Journal of Biological Chemistry  1979 254:2020-2027  PMID:500690
  
  
• Cochrane, C. G., Griffin, J. H. Molecular assembly in the contact phase of the Hageman factor system American Journal of Medicine  1979 67:657-664  DOI:10.1016/0002-9343(79)90253-5  PMID:386794
• Wiggins, R. C., Cochrane, C. G., Griffin, J. H. Rabbit blood coagulation factor XI. Mechanism of activation of rabbit Hageman factor (factor XII) Thrombosis Research  1979 15:487-495  DOI:10.1016/0049-3848(79)90154-3  PMID:494157
• Wiggins, R. C., Cochrane, C. G., Griffin, J. H. Rabbit blood coagulation factor XI. Purification and properties Thrombosis Research  1979 15:475-486  DOI:10.1016/0049-3848(79)90153-1  PMID:494156
• Griffin, J. H., Cochrane, C. G. Recent advances in the understanding of contact activation reactions Seminars in Thrombosis and Hemostasis  1979 5:254-273  PMID:386517
• Cochrane, C. G., Revak, S. D., Wiggins, R. C., Griffin, J. H. The Hageman Factor system in inflammation Advances in Inflammation Research  1979 1:249-261
• Davis, S., Furie, B. C., Griffin, J. H., Furie, B. Circulating inhibitors of blood-coagulation associated with procainamide-induced lupus-erythematosus American Journal of Hematology  1978 4:401-407  DOI:10.1002/ajh.2830040411  PMID:717399
• Bouma, B. N., Griffin, J. H. Deficiency of factor-XII-dependent plasminogen proactivator in prekallikrein-deficient plasma Journal of Laboratory and Clinical Medicine  1978 91:148-155  PMID:73563
• Seligsohn, U., Osterud, B., Griffin, J. H., Rapaport, S. I. Evidence for the participation of both activated factor-XII and activated factor-IX in cold-promoted activation of factor-VII Thrombosis Research  1978 13:1049-1056  DOI:10.1016/0049-3848(78)90233-5  PMID:749262
• Osterud, B., Bouma, B. N., Griffin, J. H. Human-blood coagulation factor-IX - purification, properties, and mechanism of activation by activated factor-XI Journal of Biological Chemistry  1978 253:5946-5951  PMID:681330
• Griffin, J. H. Role of surface in surface-dependent activation of Hageman-factor (blood-coagulation factor-XII) Proceedings of the National Academy of Sciences of the United States of America  1978 75:1998-2002  DOI:10.1073/pnas.75.4.1998  PMID:273926
• Revak, S. D., Cochrane, C. G., Bouma, B. N., Griffin, J. H. Surface and fluid phase activities of two forms of activated Hageman factor produced during contact activation of plasma Journal of Experimental Medicine  1978 147:719-729  DOI:10.1084/jem.147.3.719  PMID:632748  PMCID:PMC2184209
• Kerbiriou, D., Herve, G., Griffin, J. H. Aspartate-transcarbamylase lacking catalytic subunit interactions - study of conformational-changes by uv absorbance and circular-dichroism spectroscopy Journal of Biological Chemistry  1977 252:2881-2890  PMID:323258
• Griffin, J. H., Dibello, C., Alazard, R., Nicolas, P., Cohen, P. Carbon-13 nuclear magnetic-resonance studies of binding of selectively 13C-enriched oxytocins to neurohypophyseal protein, bovine neurophysin-II Biochemistry  1977 16:4194-4198  DOI:10.1021/bi00638a010  PMID:561612
• Bouma, B. N., Griffin, J. H. Human blood coagulation factor-XI - purification, properties, and mechanism of activation by activated factor-XII Journal of Biological Chemistry  1977 252:6432-6437  PMID:893417
• Wiggins, R. C., Bouma, B. N., Cochrane, C. G., Griffin, J. H. Role of high-molecular-weight kininogen in surface-binding and activation of coagulation Factor XI and prekallikrein Proceedings of the National Academy of Sciences of the United States of America  1977 74:4636-4640  DOI:10.1073/pnas.74.10.4636  PMID:270705  PMCID:PMC432002
• Convert, O., Griffin, J. H., Dibello, C., Nicolas, P., Cohen, P. Selectively enriched 13C-labeled proline-7 and 13C-labeled leucine-8 ocytocins as probes for analysis of peptide hormone interactions with bovine neurophysin i using 13C nuclear magnetic-resonance spectroscopy Biochemistry  1977 16:5061-5065  DOI:10.1021/bi00642a018  PMID:562184
• Revak, S. D., Cochrane, C. G., Griffin, J. H. The binding and cleavage characteristics of human Hageman factor during contact activation. A comparison of normal plasma with plasmas deficient in factor XI, prekallikrein, or high molecular weight kininogen Journal of Clinical Investigation  1977 59:1167-1175  DOI:10.1172/jci108741  PMID:864009  PMCID:PMC372330
• Griffin, J. H., Cochrane, C. G. Human factor XII (Hageman factor) Methods in Enzymology  1976 45:56-65  DOI:10.1016/S0076-6879(76)45009-7  PMID:1012017
• Griffin, J. H., Cochrane, C. G. Mechanisms for the involvement of high molecular weight kininogen in surface-dependent reactions of Hageman factor Proceedings of the National Academy of Sciences of the United States of America  1976 73:2554-2558  DOI:10.1073/pnas.73.8.2554  PMID:1066663  PMCID:PMC430686
• Griffin, J. H., Furie, B., Schechter, A. N. Application of nuclear magnetic-resonance spectroscopy to proteins Biochimie  1975 57:453-460  DOI:10.1016/s0300-9084(75)80332-4  PMID:1148335
• Griffin, J. H., Alazard, R., Dibello, C., Sala, E., Mermetbouvier, R., Cohen, P. Carbon-13 nuclear magnetic-resonance studies on (85 percent 13C-enriched Gly9) oxytocin FEBS Letters  1975 50:168-171  DOI:10.1016/0014-5793(75)80481-9  PMID:1112410
• Griffin, J. H., Cohen, J. S., Cohen, P., Camier, M. Drug-biomolecule interactions - proton magnetic-resonance studies of complex-formation between bovine neurophysins and oxytocin at molecular level Journal of Pharmaceutical Sciences  1975 64:507-511  DOI:10.1002/jps.2600640341  PMID:239193
• Wolff, J., Alazard, R., Camier, M., Griffin, J. H., Cohen, P. Interactions of bovine neurophysins with neurohypophyseal hormones - role of tyrosine-49 Journal of Biological Chemistry  1975 250:5215-5220  PMID:1150656
• Cohen, P., Camier, M., Wolff, J., Alazard, R., Cohen, J. S., Griffin, J. H. Studies of bovine neurophysin-neurohypophyseal hormone interactions Annals of the New York Academy of Sciences  1975 248:463-479  DOI:10.1111/j.1749-6632.1975.tb34207.x  PMID:235235
• Alazard, R., Cohen, P., Cohen, J. S., Griffin, J. H. Interactions of bovine neurophysin-II with oxytocin and 8-lysine vasopressin - high-resolution proton nuclear magnetic-resonance spectroscopy studies Journal of Biological Chemistry  1974 249:6895-6900  PMID:4423570
• Furie, B., Griffin, J. H., Feldmann, R. J., Sokoloski, E. A., Schechter, A. N. The active site of staphylococcal nuclease: paramagnetic relaxation of bound nucleotide inhibitor nuclei by lanthanide ions Proceedings of the National Academy of Sciences of the United States of America  1974 71:2833-2837  DOI:10.1073/pnas.71.7.2833  PMID:4528015  PMCID:PMC388566
• Rosenbusch, J. P., Griffin, J. H. Carbamyl phosphate binding to aspartate transcarbamylase. Partial saturation and its alteration by succinate Journal of Biological Chemistry  1973 248:5063-5066  PMID:4577764
• Griffin, J. H., Alazard, R., Cohen, P. Complex-formation between bovine neurophysin-I and oxytocin, vasopressin, and tripeptide analogs of their NH2-terminal region - absorbance and circular-dichroism difference spectroscopic studies Journal of Biological Chemistry  1973 248:7975-7978  PMID:4796247
• Griffin, J. H., Rosenbusch, J. P., Blout, E. R., Weber, K. K. Conformational changes in aspartate transcarbamylase. II. Circular dichroism evidence for the involvement of metal ions in allosteric interactions Journal of Biological Chemistry  1973 248:5057-5062  PMID:4577763
• Griffin, J. H., Schechter, A. N., Cohen, J. S. Nuclear magnetic resonance studies of a ribonuclease-dinucleoside phosphonate complex and their implications for the mechanism of the enzyme Annals of the New York Academy of Sciences  1973 222:693-708  DOI:10.1111/j.1749-6632.1973.tb15296.x  PMID:4522440
• Cohen, J. S., Griffin, J. H., Schechter, A. N. Nuclear magnetic resonance titration curves of histidine ring protons. IV. The effects of phosphate and sulfate on ribonuclease Journal of Biological Chemistry  1973 248:4305-4310  PMID:4736427
• Griffin, J. H., Cohen, J. S., Schechter, A. N. The assignment of an exchangeable low-field NH proton resonance of ribonuclease A to the active-site histidine-119 Biochemistry  1973 12:2096-2099  DOI:10.1021/bi00735a012  PMID:4735881
• Griffin, J. H., Rosenbusch, J. P., Weber, K. K., Blout, E. R. Conformational changes in aspartate trancarbamylase. I. Studies of ligand binding and of subunit interactions by circular dichroism spectroscopy Journal of Biological Chemistry  1972 247:6482-6490  PMID:4561937
• Cohen, P., Griffin, J. H., Camier, M., Caizergues, M., Fromageot, P., Cohen, J. S. Hormonal interactions at the molecular level: A high resolution proton magnetic resonance study of bovine neurophysins and their interactions with oxytocin FEBS Letters  1972 25:282-286  DOI:10.1016/0014-5793(72)80504-0  PMID:11946770
• Griffin, J. H., Criddle, R. S. Substrate-inhibited lactate dehydrogenase. Reaction mechanism and essential role of dissociated subunits Biochemistry  1970 9:1195-1205  DOI:10.1021/bi00807a021  PMID:4313938