recent publications
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academic article
- Wang, M., Datta, D., Enwright, J., Galvin, V., Yang, S. T., Paspalas, C., Kozak, R., Gray, D. L., Lewis, D. A., Arnsten, A. F. T. A novel dopamine D1 receptor agonist excites delay-dependent working memory-related neuronal firing in primate dorsolateral prefrontal cortex Neuropharmacology 2019 150:46-58 DOI:10.1016/j.neuropharm.2019.03.001 PMID:30858103 PMCID:PMC6475613
- Davoren, J. E., Nason, D., Coe, J., Dlugolenski, K., Helal, C., Harris, A. R., LaChapelle, E., Liang, S., Liu, Y., O'Connor, R., Orozco, C. C., Rai, B. K., et al. Discovery and lead optimization of atropisomer D1 agonists with reduced desensitization Journal of Medicinal Chemistry 2018 61:11384-11397 DOI:10.1021/acs.jmedchern.8b01622 PMID:30431269
- Papapetropoulos, S., Liu, W., Duvvuri, S., Thayer, K., Gray, D. L. Evaluation of D-1/D-5 partial agonist PF-06412562 in Parkinson's Disease following oral administration Neurodegenerative Diseases 2018 18:262-269 DOI:10.1159/000492498 PMID:30453303
- Gray, D. L., Allen, J. A., Mente, S., O'Connor, R. E., DeMarco, G. J., Efremov, I., Tierney, P., Volfson, D., Davoren, J., Guilmette, E., Salafia, M., Kozak, R., et al. Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor Nature Communications 2018 9 DOI:10.1038/s41467-017-02776-7 PMID:29445200 PMCID:PMC5813016
- Arnsten, A. F. T., Girgis, R. R., Gray, D. L., Mailman, R. B. Novel dopamine therapeutics for cognitive deficits in schizophrenia Biological Psychiatry 2017 81:67-77 DOI:10.1016/j.biopsych.2015.12.028 PMID:26946382
- Sciabola, S., Goetz, G. H., Bai, G., Rogers, B. N., Gray, D. L., Duplantier, A., Fonseca, K. R., Vanase-Frawley, M. A., Kablaoui, N. M. Systematic N-methylation of oxytocin: Impact on pharmacology and intramolecular hydrogen bonding network Bioorganic & Medicinal Chemistry 2016 24:3513-3520 DOI:10.1016/j.bmc.2016.05.062 PMID:27297999
- Mente, S., Guilmette, E., Salafia, M., Gray, D. Dopamine D1 receptor-agonist interactions: A mutagenesis and homology modeling study Bioorganic & Medicinal Chemistry Letters 2015 25:2106-2111 DOI:10.1016/j.bmcl.2015.03.079 PMID:25881819
- Davoren, J. E., Bundesmann, M. W., Yan, Q. T., Collantes, E. M., Mente, S., Nason, D. M., Gray, D. L. Measurement of atropisomer racemization kinetics using segmented flow technology ACS Medicinal Chemistry Letters 2012 3:433-435 DOI:10.1021/ml2003108 PMID:24900489 PMCID:PMC4025797
- Li, C. S. W., Zhang, L., Haske, T., Dounay, A., Gray, D., Barta, N., Brodfuehrer, J., Lepsy, C., Campbell, B. Mechanism-based pharmacokinetic/pharmacodynamic modeling of rat prefrontal cortical dopamine response to dual acting norepinephrine reuptake inhibitor and 5-HT1A partial agonist AAPS Journal 2012 14:365-376 DOI:10.1208/s12248-012-9343-8 PMID:22454087 PMCID:PMC3326163
- Palui, G., Avellini, T., Zhan, N., Pan, F., Gray, D., Alabugin, I., Mattoussi, H. Photoinduced phase transfer of luminescent quantum dots to polar and aqueous media. Journal of the American Chemical Society 2012 134:16370-16378 DOI:10.1021/ja306621n PMID:22938162
- Sakya, S. M., Flick, A. C., Coe, J. W., Gray, D. L., Liang, S., Ferri, F., Van Den Berg, M., Pouwer, K. Synthesis of 4-azepanones and heteroaromatic-fused azepines Tetrahedron Letters 2012 53:723-725 DOI:10.1016/tetlet.2011.11.129
- Pettersson, M., Campbell, B. M., Dounay, A. B., Gray, D. L., Xie, L., O'Donnell, C. J., Stratman, N. C., Zoski, K., Drummond, E., Bora, G., Probert, A., Whisman, T. Design, synthesis, and pharmacological evaluation of azetedine and pyrrolidine derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists Bioorganic & Medicinal Chemistry Letters 2011 21:865-868 DOI:10.1016/j.bmcl.2010.11.066 PMID:21185183
- Wang, Z., Chi, Y., Harris, A. R., Gray, D., Davoren, J. E. Scalable synthesis of 4-substituted 5-bromo-6-methylpyrimidines Synthesis-Stuttgart 2011 1529-1531 DOI:10.1055/s-0030-1259976
- Harris, A. R., Nason, D. M., Collantes, E. M., Xu, W., Chi, Y. S., Wang, Z., Zhang, B., Zhang, Q., Gray, D. L., Davoren, J. E. Synthesis of 5-bromo-6-methyl imidazopyrazine, 5-bromo and 5-chloro-6-methyl imidazopyridine using electron density surface maps to guide synthetic strategy Tetrahedron 2011 67:9063-9066 DOI:10.1016/j.tet.2011.08.090
- Dounay, A. B., Barta, N. S., Campbell, B. M., Coleman, C., Collantes, E. M., Denny, L., Dutta, S., Gray, D. L., Hou, D. F., Iyer, R., Maiti, S. N., Ortwine, D. F., et al. Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists Bioorganic & Medicinal Chemistry Letters 2010 20:1114-1117 DOI:10.1016/j.bmcl.2009.12.023 PMID:20031410
- Davoren, J. E., Gray, D. L., Harris, A. R., Nason, D. M., Xu, W. Remarkable [3+2] annulations of electron-rich olefins with unstabilized azomethine ylides Synlett 2010 2490-2492 DOI:10.1055/s-0030-1258026
- Dounay, A. B., Barta, N. S., Bikker, J. A., Borosky, S. A., Campbell, B. M., Crawford, T., Denny, L., Evans, L. M., Gray, D. L., Lee, P., Lenoir, E. A., Xu, W. Synthesis and pharmacological evaluation of aminopyrimidine series of 5-HT1A partial agonists Bioorganic & Medicinal Chemistry Letters 2009 19:1159-1163 DOI:10.1016/j.bmcl.2008.12.087 PMID:19147349
- Fish, P. V., Barta, N. S., Gray, D. L. F., Ryckmans, T., Stobie, A., Wakenhut, F., Whitlock, G. A. Derivatives of (3S)-N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modulation of H-bond acceptor capacity Bioorganic & Medicinal Chemistry Letters 2008 18:4355-4359 DOI:10.1016/j.bmcl.2008.06.071 PMID:18621528
- Xu, W., Gray, D. L., Glase, S. A., Barta, N. S. Design and synthesis of reboxetine analogs morpholine derivatives as selective norepinephrine reuptake inhibitors Bioorganic & Medicinal Chemistry Letters 2008 18:5550-5553 DOI:10.1016/j.bmcl.2008.09.007 PMID:18805691
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Nicolaou, K. C.*, Gray, D. L. F.*, Tae, J. S.
Total synthesis of hamigerans and analogues thereof. Photochemical generation and diels-alder trapping of hydroxy-o-quinodimethanes
Journal of the American Chemical Society
2004
126:613-627
DOI:10.1021/ja030498f
PMID:14719961
(* = equal contribution)
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Nicolaou, K. C.*, Gray, D. L. F.*
Total synthesis of hybocarpone and analogues thereof. A facile dimerization of naphthazarins to pentacyclic systems
Journal of the American Chemical Society
2004
126:607-612
DOI:10.1021/ja030497n
PMID:14719960
(* = equal contribution)
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Nicolaou, K. C.*, Gray, D. L. F.*, Montagnon, T., Harrison, S. T.
Oxidation of silyl enol ethers by using IBX and IBX.N-oxide complexes: a mild and selective reaction for the synthesis of enones
Angewandte Chemie-International Edition
2002
41:996-1000
DOI:10.1002/1521-3773(20020315)41:6<996::aid-anie996>3.0.co;2-i
PMID:12491292
(* = equal contribution)
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Nicolaou, K. C.*, Gray, D.*, Tae, J. S.
Total synthesis of hamigerans: Part 1. Development of synthetic technology for the construction of benzannulated polycyclic systems by the intramolecular trapping of photogenerated hydroxy-o-quinodimethanes and synthesis of key building blocks
Angewandte Chemie-International Edition
2001
40:3675-3678
DOI:10.1002/1521-3773(20011001)40:19<3675::aid-anie3675>3.0.co;2-g
PMID:11592219
(* = equal contribution)
-
Nicolaou, K. C.*, Gray, D.*, Tae, J. S.
Total synthesis of hamigerans: Part 2. Implementation of the intramolecular diels-alder trapping of photochemically generated hydroxy-o-quinodimethanes; strategy and completion of the synthesis
Angewandte Chemie-International Edition
2001
40:3679-3683
DOI:10.1002/1521-3773(20011001)40:19<3679::aid-anie3679>3.0.co;2-t
PMID:11592220
(* = equal contribution)
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Nicolaou, K. C.*, Gray, D.*
Total synthesis of hybocarpone
Angewandte Chemie-International Edition
2001
40:761-763
DOI:10.1002/1521-3773(20010216)40:4<761::aid-anie7610>3.3.co;2-s
PMID:11241615
(* = equal contribution)
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Nicolaou, K. C., Murphy, F., Barluenga, S., Ohshima, T., Wei, H., Xu, J., Gray, D. L. F., Baudoin, O.
Total synthesis of the novel immunosuppressant sanglifehrin a
Journal of the American Chemical Society
2000
122:3830-3838
DOI:10.1021/ja994285v
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Nicolaou, K. C., Xu, J. Y., Murphy, F., Barluenga, S., Baudoin, O., Wei, H. X., Gray, D. L. F., Ohshima, T.
Total synthesis of sanglifehrin A
Angewandte Chemie-International Edition
1999
38:2447-2451
DOI:10.1002/(sici)1521-3773(19990816)38:16<2447::aid-anie2447>3.0.co;2-o
PMID:10458817