recent publications
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academic article
- Karki, R. G., Powers, J., Mainolfi, N., Anderson, K., Belanger, D. B., Liu, D., Ji, N., Jendza, K., Gelin, C. F., Mac Sweeney, A., Solovay, C., Delgado, O., et al. Design, synthesis, and preclinical characterization of selective factor D inhibitors targeting the alternative complement pathway Journal of Medicinal Chemistry 2019 62:4656-4668 DOI:10.1021/acs.jmedchem.9b00271 PMID:30995036
- Chrovian, C. C., Soyode-Johnson, A., Peterson, A. A., Gelin, C. F., Deng, X., Dvorak, C. A., Carruthers, N. I., Lord, B., Fraser, I., Aluisio, L., Coe, K. J., Scott, B., et al. A dipolar cycloaddition reaction to access 6-methyl-4,5,6,7-tetrahydro-1H 1,2,3 triazolo 4,5-c pyridines enables the discovery synthesis and preclinical profiling of a P2X7 antagonist clinical candidate Journal of Medicinal Chemistry 2018 61:207-223 DOI:10.1021/acs.jmedchem.7b01279 PMID:29211470
- Letavic, M. A., Savall, B. M., Allison, B. D., Aluisio, L., Andres, J. I., De Angelis, M., Ao, H., Beauchamp, D. A., Bonaventure, P., Bryan, S., CarruthersT, N. I., Ceusters, M., et al. 4-Methyl-6,7-dihydro-4H-triazolo 4,5-c pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate Journal of Medicinal Chemistry 2017 60:4559-4572 DOI:10.1021/acs.jmedchem.7b00408 PMID:28493698
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Nicolaou, K. C.*, Gelin, C. F.*, Seo, J. H., Huang, Z. H., Umezawa, T.
Synthesis of the QRSTU domain of maitotoxin and its 85-epi- and 86-epi-diastereoisomers
Journal of the American Chemical Society
2010
132:9900-9907
DOI:10.1021/ja103708j
PMID:20666400
PMCID:PMC2913318
(* = equal contribution)
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Narita, T., Yin, S. M., Gelin, C. F., Moreno, C. S., Yepes, M., Nicolaou, K. C., Van Meir, E. G.
Identification of a novel small molecule HIF-1-α translation inhibitor
Clinical Cancer Research
2009
15:6128-6136
DOI:10.1158/1078-0432.ccr-08-3180
PMID:19789328
PMCID:PMC2770235
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Nicolaou, K. C., Lister, T., Denton, R. M., Gelin, C. F.
Total synthesis of atrochamins F, H, I, and J through cascade reactions
Tetrahedron
2008
64:4736-4757
DOI:10.1016/j.tet.2008.02.108
PMID:19461992
PMCID:PMC2597834
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Nicolaou, K. C., Lister, T., Denton, R. M., Gelin, C. F.
Cascade reactions involving formal [2+2] thermal cycloadditions: total synthesis of artochamins F, H, I, and J
Angewandte Chemie-International Edition
2007
46:7501-7505
DOI:10.1002/anie.200702363
PMID:17768746