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Gelin, Christine
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Gelin, Christine

Graduate Student
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Positions

  • 2012 - Senior Scientist, Janssen, Pharmaceutical Companies of Johnson and Johnson
  • 2010 - 2012 Research Investigator II, Novartis Institutes for BioMedical Research

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Publications

recent publications
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  • academic article

    • Karki, R. G., Powers, J., Mainolfi, N., Anderson, K., Belanger, D. B., Liu, D., Ji, N., Jendza, K., Gelin, C. F., Mac Sweeney, A., Solovay, C., Delgado, O., et al. Design, synthesis, and preclinical characterization of selective factor D inhibitors targeting the alternative complement pathway Journal of Medicinal Chemistry  2019 62:4656-4668  DOI:10.1021/acs.jmedchem.9b00271  PMID:30995036
    • Chrovian, C. C., Soyode-Johnson, A., Peterson, A. A., Gelin, C. F., Deng, X., Dvorak, C. A., Carruthers, N. I., Lord, B., Fraser, I., Aluisio, L., Coe, K. J., Scott, B., et al. A dipolar cycloaddition reaction to access 6-methyl-4,5,6,7-tetrahydro-1H 1,2,3 triazolo 4,5-c pyridines enables the discovery synthesis and preclinical profiling of a P2X7 antagonist clinical candidate Journal of Medicinal Chemistry  2018 61:207-223  DOI:10.1021/acs.jmedchem.7b01279  PMID:29211470
    • Letavic, M. A., Savall, B. M., Allison, B. D., Aluisio, L., Andres, J. I., De Angelis, M., Ao, H., Beauchamp, D. A., Bonaventure, P., Bryan, S., CarruthersT, N. I., Ceusters, M., et al. 4-Methyl-6,7-dihydro-4H-triazolo 4,5-c pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate Journal of Medicinal Chemistry  2017 60:4559-4572  DOI:10.1021/acs.jmedchem.7b00408  PMID:28493698
    • degree-related publication Nicolaou, K. C.*, Gelin, C. F.*, Seo, J. H., Huang, Z. H., Umezawa, T. Synthesis of the QRSTU domain of maitotoxin and its 85-epi- and 86-epi-diastereoisomers Journal of the American Chemical Society  2010 132:9900-9907  DOI:10.1021/ja103708j  PMID:20666400  PMCID:PMC2913318 (* = equal contribution)
    • degree-related publication Narita, T., Yin, S. M., Gelin, C. F., Moreno, C. S., Yepes, M., Nicolaou, K. C., Van Meir, E. G. Identification of a novel small molecule HIF-1-α translation inhibitor Clinical Cancer Research  2009 15:6128-6136  DOI:10.1158/1078-0432.ccr-08-3180  PMID:19789328  PMCID:PMC2770235
    • degree-related publication Nicolaou, K. C., Lister, T., Denton, R. M., Gelin, C. F. Total synthesis of atrochamins F, H, I, and J through cascade reactions Tetrahedron  2008 64:4736-4757  DOI:10.1016/j.tet.2008.02.108  PMID:19461992  PMCID:PMC2597834
    • degree-related publication Nicolaou, K. C., Lister, T., Denton, R. M., Gelin, C. F. Cascade reactions involving formal [2+2] thermal cycloadditions: total synthesis of artochamins F, H, I, and J Angewandte Chemie-International Edition  2007 46:7501-7505  DOI:10.1002/anie.200702363  PMID:17768746
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Background

education and training

  • Ph.D. in Chemistry, Scripps Research 2005 - 2010
  • B.S. in Chemistry, University of California, Los Angeles , Transferred from University of California, Irvine 2003 - 2005

advisee of

  • graduate advising relationship

    • Nicolaou, K.C., Ph.D.  candidacy, 2006 - 2010
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Contact

full name

  • Christine Fang Gelin

geographic location

  • Scripps California 

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