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Dyson, Jane
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Dyson, Jane

Faculty Member
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Positions

  • 2013 - Professor, Integrative Structural and Computational Biology (ISCB) , Scripps Research
  • 1984 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 1984 - 2012 Professor, Molecular Biology , Scripps Research
Dr. Helen Jane Dyson uses NMR to study the protein-folding process and to study the nature and behavior of unfolded and partly folded forms of proteins, including prion proteins and several newly-discovered, intrinsically unstructured proteins.

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  • dyson@scripps.edu

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  • Jane Dyson, Ph.D.
  • Dyson Laboratory
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Publications

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    • Singh, J. K., Hutt, D. M., Tait, B., Guy, N. C., Sivils, J. C., Ortiz, N. R., Payan, A. N., Komaragiri, S. K., Owens, J. J., Culbertson, D., Blair, L. J., Dickey, C., et al. Management of Hsp90-dependent protein folding by small molecules targeting the Aha1 co-chaperone Cell Chemical Biology  2020 27:292-305  DOI:10.1016/j.chembiol.2020.01.008  PMID:32017918  PMCID:PMC7144688
    • Singh, A., Dyson, H. J. Backbone and side-chain chemical shift assignments of p50 subunit of NF-κB transcription factor Biomolecular Nmr Assignments  2020  DOI:10.1007/s12104-020-09978-z  PMID:32936430
    • Jackson, M. B., Dyson, J. Editors' Note Biophysical Journal  2020 119:E01-E01  DOI:10.1016/j.bpj.2020.08.033  PMID:32910901  PMCID:PMC7568000
    • Dyson, H. J. Reflections on the Pandemic Biophysical Journal  2020 119:E1-E1  DOI:10.1016/j.bpj.2020.07.018  PMID:32771077  PMCID:PMC7414318
    • Aoto, P. C., Stanfield, R. L., Wilson, I. A., Dyson, H. J., Wright, P. E. A dynamic switch in inactive p38γ leads to an excited state on the pathway to an active kinase Biochemistry  2019 58:5160-5172  DOI:10.1021/acs.biochem.9b00932  PMID:31794659  PMCID:PMC6932632
    • Dyson, H. J., Wright, P. E. Perspective: the essential role of NMR in the discovery and characterization of intrinsically disordered proteins Journal of Biomolecular NMR  2019  DOI:10.1007/s10858-019-00280-2  PMID:31617035
    • Wu, H., Dyson, H. J. Aggregation of zinc-free p53 is inhibited by Hsp90 but not other chaperones Protein Science  2019  DOI:10.1002/pro.3726  PMID:31503385
    • Berlow, R. B., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Role of backbone dynamics in modulating the interactions of disordered ligands with the TAZ1 domain of the CREB-binding protein Biochemistry  2019 58:1354-1362  DOI:10.1021/acs.biochem.8b01290  PMID:30775911  PMCID:PMC6414276
    • Dyson, J. A journal for all biophysics Biophysical Journal  2019 116:E1-E1  DOI:10.1016/j.bpj.2018.12.001  PMID:30553436
    • Sung, X., Jaeger, M., Kelly, J. W., Dyson, J. H., Wright, P. E. Mispacking of the Phe87 side chain reduces the kinetic stability of human transthyretin Biochemistry  2018 57:6919-6922  DOI:10.1021/acs.biochem.8b01046  PMID:30540442
    • Shnitkind, S., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Structural basis for graded inhibition of CREB:DNA interactions by multi-site phosphorylation Biochemistry  2018 57:6964-6972  DOI:10.1021/acs.biochem.8b01092  PMID:30507144
    • Krois, A. S., Dyson, H. J., Wright, P. E. Long-range regulation of p53 DNA binding by its intrinsically disordered N-terminal transactivation domain Proceedings of the National Academy of Sciences of the United States of America  2018 115:E11302-E11310  DOI:10.1073/pnas.1814051115  PMID:30420502  PMCID:PMC6275486
    • Yang, K., Stanfield, R. L., Martinez-Yamout, M. A., Dyson, H. J., Wilson, I. A., Wright, P. E. Structural basis for cooperative regulation of KIX-mediated transcription pathways by the HTLV-1 HBZ activation domain Proceedings of the National Academy of Sciences of the United States of America  2018 115:10040-10045  DOI:10.1073/pnas.1810397115  PMID:30232260  PMCID:PMC6176603
    • Berlow, R. B., Dyson, H. J., Wright, P. E. Expanding the Paradigm: Intrinsically Disordered Proteins and Allosteric Regulation Journal of Molecular Biology  2018 430:2309-2320  DOI:10.1016/j.jmb.2018.04.003  PMID:29634920  PMCID:PMC6045455
    • Leach, B. I., Zhang, X., Kelly, J. W., Dyson, H. J., Wright, P. E. NMR measurements reveal the structural basis of transthyretin destabilization by pathogenic mutations Biochemistry  2018 57:4421-4430  DOI:10.1021/acs.biochem.8b00642  PMID:29972637  PMCID:PMC6067956
    • Dyson, H. J., Wright, P. E. How do intrinsically disordered viral proteins hijack the cell? Biochemistry  2018 57:4045-4046  DOI:10.1021/acs.biochem.8b00622  PMID:29952542  PMCID:PMC6054125
    • Sun, X., Dyson, H. J., Wright, P. E. Kinetic analysis of the multistep aggregation pathway of human transthyretin Proceedings of the National Academy of Sciences of the United States of America  2018 115:E6201-E6208  DOI:10.1073/pnas.1807024115  PMID:29915031
    • Nikolova, E. N., Stanfield, R. L., Dyson, H. J., Wright, P. E. CH···O hydrogen bonds mediate highly specific recognition of methylated CpG sites by the zinc finger protein kaiso Biochemistry  2018 57:2109-2120  DOI:10.1021/acs.biochem.8600065  PMID:29546986  PMCID:PMC5893398
    • Dyson, J. Is the BJ review process gender-biased? Biophysical Journal  2018 114:E1-E1  DOI:10.1016/j.bpj.2018.02.007  PMID:29539410  PMCID:PMC5883556
    • Wu, H., Hyun, J., Martinez-Yamout, M. A., Park, S. J., Dyson, H. J. Characterization of an Hsp90-Independent Interaction between Co-Chaperone p23 and Transcription Factor p53 Biochemistry  2018 57:935-944  DOI:10.1021/acs.biochem.7b01076  PMID:29334217  PMCID:PMC5811392
    • Fenwick, R. B., Oyen, D., Dyson, H. J., Wright, P. E. Slow dynamics of tryptophan-water networks in proteins Journal of the American Chemical Society  2018 140:675-682  DOI:10.1021/jacs.7b09974  PMID:29256600  PMCID:PMC5771866
    • Sun, X., Dyson, H. J., Wright, P. E. Fluorotryptophan incorporation modulates the structure and stability of transthyretin in a site-specific manner Biochemistry  2017 56:5570-5581  DOI:10.1021/acs.biochem.7b00815  PMID:28920433  PMCID:PMC5645263
    • Oyen, D., Fenwick, R. B., Aoto, P. C., Stanfield, R. L., Wilson, I. A., Dyson, H. J., Wright, P. E. Defining the structural basis for allosteric product release from E. coli dihydrofolate reductase using NMR relaxation dispersion Journal of the American Chemical Society  2017 139:11233-11240  DOI:10.1021/jacs.7b05958  PMID:28737940  PMCID:PMC5562155
    • Park, S., Phukan, P. D., Zeeb, M., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Structural basis for interaction of the tandem zinc finger domains of human muscleblind with cognate RNA from human cardiac troponin T Biochemistry  2017 56:4154-4168  DOI:10.1021/acs.biochem.7b00484  PMID:28718627  PMCID:PMC5560242
    • Berlow, R. B., Dyson, H. J., Wright, P. E. Hypersensitive termination of the hypoxic response by a disordered protein switch Nature  2017 543:447-451  DOI:10.1038/nature21705  PMID:28273070  PMCID:PMC5375031
    • Dembinski, H. E., Wismer, K., Vargas, J. D., Suryawanshi, G. W., Kern, N., Kroon, G., Dyson, H. J., Hoffmann, A., Komives, E. A. Functional importance of stripping in NFκB signaling revealed by a stripping-impaired IκBα mutant Proceedings of the National Academy of Sciences of the United States of America  2017 114:1916-1921  DOI:10.1073/pnas.1610192114  PMID:28167786  PMCID:PMC5338396
    • Dyson, H. J., Wright, P. E. How does your protein fold? Elucidating the apomyoglobin folding pathway Accounts of Chemical Research  2017 50:105-111  DOI:10.1021/acs.accounts.6b00511  PMID:28032989  PMCID:PMC5241236
    • Haberz, P., Arai, M., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Mapping the interactions of adenoviral E1A proteins with the p160 nuclear receptor coactivator binding domain of CBP Protein Science  2016 25:2256-2267  DOI:10.1002/pro.3059  PMID:27699893  PMCID:PMC5119557
    • Bhowmick, A., Brookes, D. H., Yost, S. R., Dyson, H. J., Forman-Kay, J. D., Gunter, D., Head-Gordon, M., Hura, G. L., Pande, V. S., Wemmer, D. E., Wright, P. E., Head-Gordon, T. Finding our way in the dark proteome Journal of the American Chemical Society  2016 138:9730-9742  DOI:10.1021/jacs.6b06543  PMID:27387657  PMCID:PMC5051545
    • Hsu, C. H., Park, S., Mortenson, D. E., Foley, B. L., Wang, X., Woods, R. J., Case, D. A., Powers, E. T., Wong, C. H., Dyson, H. J., Kelly, J. W. The dependence of carbohydrate-aromatic interaction strengths on the structure of the carbohydrate Journal of the American Chemical Society  2016 138:7636-7648  DOI:10.1021/jacs.6b02879  PMID:27249581  PMCID:PMC4924591
    • Mukherjee, S. P., Quintas, P. O., McNulty, R., Komives, E. A., Dyson, H. J. Structural characterization of the ternary complex that mediates termination of NF-κB signaling by IκBα Proceedings of the National Academy of Sciences of the United States of America  2016 113:6212-6217  DOI:10.1073/pnas.1603488113  PMID:27185953  PMCID:PMC4896678
    • Krois, A. S., Ferreon, J. C., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein Proceedings of the National Academy of Sciences of the United States of America  2016 113:E1853-E1862  DOI:10.1073/pnas.1602487113  PMID:26976603  PMCID:PMC4822595
    • Dyson, H. J., Wright, P. E. Role of intrinsic protein disorder in the function and interactions of the transcriptional coactivators CREB-binding protein (CBP) and p300 Journal of Biological Chemistry  2016 291:6714-6722  DOI:10.1074/jbc.R115.692020  PMID:26851278  PMCID:PMC4807259
    • Dyson, H. J. Making sense of intrinsically disordered proteins Biophysical Journal  2016 110:1013-1016  DOI:10.1016/j.bpj.2016.01.030  PMID:26958875  PMCID:PMC4788759
    • Mukherjee, S. P., Borin, B., Quintas, P. O., Dyson, H. J. NMR characterization of a 72 kDa transcription factor using differential isotopic labeling Protein Science  2016 25:597-604  DOI:10.1002/pro.2853  PMID:26647230  PMCID:PMC4815403
    • Fenwick, R. B., Dyson, H. J. Classic analysis of biopolymer dynamics is model free Biophysical Journal  2016 110:3-6  DOI:10.1016/j.bpj.2015.11.022  PMID:26745403  PMCID:PMC4805862
    • Keskin, O., Dyson, H. J., Bahar, I. Biomolecular systems interactions, dynamics, and allostery: reflections and new directions Biophysical Journal  2015 109:E01-E02  DOI:10.1016/j.bpj.2015.08.005  PMID:26377787  PMCID:PMC4576319
    • Berlow, R. B., Dyson, H. J., Wright, P. E. Functional advantages of dynamic protein disorder FEBS Letters  2015 589:2433-2440  DOI:10.1016/j.febslet.2015.06.003  PMID:26073260  PMCID:PMC4586362
    • Arai, M., Sugase, K., Dyson, H. J., Wright, P. E. Conformational propensities of intrinsically disordered proteins influence the mechanism of binding and folding Proceedings of the National Academy of Sciences of the United States of America  2015 112:9614-9619  DOI:10.1073/pnas.1512799112  PMID:26195786  PMCID:PMC4534220
    • Oyen, D., Fenwick, R. B., Stanfield, R. L., Dyson, H. J., Wright, P. E. Cofactor-mediated conformational dynamics promote product release from Escherichia coli dihydrofolate reductase via an allosteric pathway Journal of the American Chemical Society  2015 137:9459-9468  DOI:10.1021/jacs.5b05707  PMID:26147643  PMCID:PMC4521799
    • Wright, P. E., Dyson, H. J. Intrinsically disordered proteins in cellular signalling and regulation Nature Reviews Molecular Cell Biology  2015 16:18-29  DOI:10.1038/nrm3920  PMID:25531225  PMCID:PMC4405151
    • Jansma, A. L., Martinez-Yamout, M. A., Liao, R., Sun, P., Dyson, H. J., Wright, P. E. The high-risk HPV16 E7 oncoprotein mediates interaction between the transcriptional coactivator CBP and the retinoblastoma protein pRb Journal of Molecular Biology  2014 426:4030-4048  DOI:10.1016/j.jmb.2014.10.021  PMID:25451029  PMCID:PMC4258470
    • Aoto, P. C., Nishimura, C., Dyson, H. J., Wright, P. E. Probing the non-native H helix translocation in apomyoglobin folding intermediates Biochemistry  2014 53:3767-3780  DOI:10.1021/bi500478m  PMID:24857522  PMCID:PMC4067146
    • Burge, R. G., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Structural characterization of interactions between the double-stranded RNA-binding zinc finger protein JAZ and nucleic acids Biochemistry  2014 53:1495-1510  DOI:10.1021/bi401675h  PMID:24521053  PMCID:PMC3985865
    • Tuttle, L. M., Dyson, H. J., Wright, P. E. Side chain conformational averaging in human dihydrofolate reductase Biochemistry  2014 53:1134-1145  DOI:10.1021/bi4015314  PMID:24498949  PMCID:PMC3985697
    • Bhabha, G., Ekiert, D. C., Jennewein, M., Zmasek, C. M., Tuttle, L. M., Kroon, G., Dyson, H. J., Godzik, A., Wilson, I. A., Wright, P. E. Divergent evolution of protein conformational dynamics in dihydrofolate reductase Nature Structural & Molecular Biology  2013 20:1243-1249  DOI:10.1038/nsmb.2676  PMID:24077226  PMCID:PMC3823643
    • Park, S., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. The CH2 domain of CBP/p300 is a novel zinc finger FEBS Letters  2013 587:2506-2511  DOI:10.1016/j.febslet.2013.06.051  PMID:23831576  PMCID:PMC3765250
    • Boehr, D. D., Schnell, J. R., McElheny, D., Bae, S. H., Duggan, B. M., Benkovic, S. J., Dyson, H. J., Wright, P. E. A distal mutation perturbs dynamic amino acid networks in dihydrofolate reductase Biochemistry  2013 52:4605-4619  DOI:10.1021/bi400563c  PMID:23758161  PMCID:PMC3838469
    • Chen, W., Enck, S., Price, J. L., Powers, D. L., Powers, E. T., Wong, C. H., Dyson, H. J., Kelly, J. W. Structural and energetic basis of carbohydrate-aromatic packing interactions in proteins Journal of the American Chemical Society  2013 135:9877-9884  DOI:10.1021/ja4040472  PMID:23742246  PMCID:PMC3715148
    • Tuttle, L. M., Dyson, H. J., Wright, P. E. Side-chain conformational heterogeneity of intermediates in the Escherichia coli dihydrofolate reductase catalytic cycle Biochemistry  2013 52:3464-3477  DOI:10.1021/bi400322e  PMID:23614825  PMCID:PMC3796204
    • Lim, K. H., Dyson, H. J., Kelly, J. W., Wright, P. E. Localized structural fluctuations promote amyloidogenic conformations in transthyretin Journal of Molecular Biology  2013 425:977-988  DOI:10.1016/j.jmb.2013.01.008  PMID:23318953  PMCID:PMC3594634
    • Cervantes, C. F., Handley, L. D., Sue, S. C., Dyson, H. J., Komives, E. A. Long-range effects and functional consequences of stabilizing mutations in the ankyrin repeat domain of IκBα Journal of Molecular Biology  2013 425:902-913  DOI:10.1016/j.jmb.2012.12.012  PMID:23274114  PMCID:PMC3744861
    • Cardoso, R., Love, R., Nilsson, C. L., Bergqvist, S., Nowlin, D., Yan, J. L., Liu, K. K. C., Zhu, J., Chen, P., Deng, Y. L., Dyson, H. J., Greig, M. J., et al. Identification of cys255 in hif-1 alpha as a novel site for development of covalent inhibitors of hif-1 alpha/arnt pasb domain protein-protein interaction Protein Science  2012 21:1885-1896  DOI:10.1002/pro.2172  PMID:23033253  PMCID:PMC3575918
    • Vila, J. A., Sue, S. C., Fraser, J. S., Scheraga, H. A., Dyson, H. J. Cheshift-2 resolves a local inconsistency between two x-ray crystal structures Journal of Biomolecular NMR  2012 54:193-198  DOI:10.1007/s10858-012-9663-0  PMID:22945426  PMCID:PMC3471536
    • Buck-Koehntop, B. A., Stanfield, R. L., Ekiert, D. C., Martinez-Yamout, M. A., Dyson, H. J., Wilson, I. A., Wright, P. E. Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein kaiso Proceedings of the National Academy of Sciences of the United States of America  2012 109:15229-15234  DOI:10.1073/pnas.1213726109  PMID:22949637  PMCID:PMC3458336
    • Zhu, J., Martinez-Yamout, M., Cardoso, R., Yan, J. L., Love, R. A., Grodsky, N., Brooun, A., Dyson, H. J. Homodimerization of the PAS-B domains of hypoxia-inducible factors Journal of Physical Chemistry B  2012 116:6960-6965  DOI:10.1021/jp300525n  PMID:22424208  PMCID:PMC3376167
    • Dyson, H. J., Komives, E. A. Role of disorder in i?B-nf?B interaction IUBMB Life  2012 64:499-505  DOI:10.1002/iub.1044  PMID:22573609  PMCID:PMC3575514
    • Buck-Koehntop, B. A., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Kaiso uses all three zinc fingers and adjacent sequence motifs for high affinity binding to sequence-specific and methyl-cpg DNA targets FEBS Letters  2012 586:734-739  DOI:10.1016/j.febslet.2012.01.045  PMID:22300642  PMCID:PMC3309074
    • Dyson, H. J. Roles of intrinsic disorder in protein-nucleic acid interactions Molecular Biosystems  2012 8:97-104  DOI:10.1039/c1mb05258f  PMID:21874205  PMCID:PMC3600845
    • Dyson, H. J. Expanding the proteome: Disordered and alternatively folded proteins Quarterly Reviews of Biophysics  2011 44:467-518  DOI:10.1017/s0033583511000060  PMID:21729349  PMCID:PMC3189428
    • Nishimura, C., Dyson, H. J., Wright, P. E. Consequences of stabilizing the natively disordered f helix for the folding pathway of apomyoglobin Journal of Molecular Biology  2011 411:248-263  DOI:10.1016/j.jmb.2011.05.028  PMID:21640124  PMCID:PMC3143293
    • Park, S. J., Kostic, M., Dyson, H. J. Dynamic interaction of hsp90 with its client protein p53 Journal of Molecular Biology  2011 411:158-173  DOI:10.1016/j.jmb.2011.05.030  PMID:21658391  PMCID:PMC3143201
    • Park, S. J., Borin, B. N., Martinez-Yamout, M. A., Dyson, H. J. The client protein p53 adopts a molten globule-like state in the presence of hsp90 Nature Structural & Molecular Biology  2011 18:537-541  DOI:10.1038/nsmb.2045  PMID:21460846  PMCID:PMC3087862
    • Bhabha, G., Lee, J., Ekiert, D. C., Gam, J., Wilson, I. A., Dyson, H. J., Benkovic, S. J., Wright, P. E. A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis Science  2011 332:234-238  DOI:10.1126/science.1198542  PMID:21474759  PMCID:PMC3151171
    • Sue, S. C., Alverdi, V., Komives, E. A., Dyson, H. J. Detection of a ternary complex of nf-kappa b and i kappa b alpha with DNA provides insights into how i kappa b alpha removes nf-kappa b from transcription sites Proceedings of the National Academy of Sciences of the United States of America  2011 108:1367-1372  DOI:10.1073/pnas.1014323108  PMID:21220295  PMCID:PMC3029698
    • Cervantes, C. F., Bergqvist, S., Kjaergaard, M., Kroon, G., Sue, S. C., Dyson, H. J., Komives, E. A. The rela nuclear localization signal folds upon binding to i kappa b alpha Journal of Molecular Biology  2011 405:754-764  DOI:10.1016/j.jmb.2010.10.055  PMID:21094161  PMCID:PMC3056351
    • Lee, C. W., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Structure of the p53 transactivation domain in complex with the nuclear receptor coactivator binding domain of creb binding protein Biochemistry  2010 49:9964-9971  DOI:10.1021/bi1012996  PMID:20961098  PMCID:PMC2982890
    • Arai, M., Dyson, H. J., Wright, P. E. Leu628 of the kix domain of cbp is a key residue for the interaction with the mll transactivation domain FEBS Letters  2010 584:4500-4504  DOI:10.1016/j.febslet.2010.10.024  PMID:20969867  PMCID:PMC2993637
    • Nishimura, C., Dyson, H. J., Wright, P. E. Energetic frustration of apomyoglobin folding: Role of the b helix Journal of Molecular Biology  2010 396:1319-1328  DOI:10.1016/j.jmb.2009.12.040  PMID:20043917  PMCID:PMC2827033
    • Boehr, D. D., McElheny, D., Dyson, H. J., Wright, P. E. Millisecond timescale fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands Proceedings of the National Academy of Sciences of the United States of America  2010 107:1373-1378  DOI:10.1073/pnas.0914163107  PMID:20080605  PMCID:PMC2824364
    • Bae, S. H., Legname, G., Serban, A., Prusiner, S. B., Wright, P. E., Dyson, H. J. Prion proteins with pathogenic and protective mutations show similar structure and dynamics Biochemistry  2009 48:8120-8128  DOI:10.1021/bi900923b  PMID:19618915  PMCID:PMC2762478
    • Cervantes, C. F., Markwick, P. R. L., Sue, S. C., McCammon, J. A., Dyson, H. J., Komives, E. A. Functional dynamics of the folded ankyrin repeats of i kappa b alpha revealed by nuclear magnetic resonance Biochemistry  2009 48:8023-8031  DOI:10.1021/bi900712r  PMID:19591507  PMCID:PMC2728578
    • Ferreon, J. C., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Structural basis for subversion of cellular control mechanisms by the adenoviral e1a oncoprotein Proceedings of the National Academy of Sciences of the United States of America  2009 106:13260-13265  DOI:10.1073/pnas.0906770106  PMID:19651603  PMCID:PMC2726373
    • Fuller, A. A., Du, D., Liu, F., Davoren, J. E., Bhabha, G., Kroon, G., Case, D. A., Dyson, H. J., Powers, E. T., Wipf, P., Gruebele, M., Kelly, J. W. Evaluating beta-turn mimics as beta-sheet folding nucleators Proceedings of the National Academy of Sciences of the United States of America  2009 106:11067-11072  DOI:10.1073/pnas.0813012106  PMID:19541614  PMCID:PMC2708776
    • Bae, S. H., Dyson, H. J., Wright, P. E. Prediction of the rotational tumbling time for proteins with disordered segments Journal of the American Chemical Society  2009 131:6814-6821  DOI:10.1021/ja809687r  PMID:19391622  PMCID:PMC2694746
    • Sue, S. C., Dyson, H. J. Interaction of the i kappa b alpha c-terminal pest sequence with nf-kappa b: Insights into the inhibition of nf-kappa b DNA binding by i kappa b alpha Journal of Molecular Biology  2009 388:824-838  DOI:10.1016/j.jmb.2009.03.048  PMID:19327364  PMCID:PMC2688455
    • Ferreon, J. C., Lee, C. W., Arai, M., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Cooperative regulation of p53 by modulation of ternary complex formation with cbp/p300 and hdm2 Proceedings of the National Academy of Sciences of the United States of America  2009 106:6591-6596  DOI:10.1073/pnas.0811023106  PMID:19357310  PMCID:PMC2672497
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    • Perez-Alvarado, G. C., Munnerlyn, A., Dyson, H. J., Grosschedl, R., Wright, P. E. Identification of the regions involved in DNA binding by the mouse PEBP2alpha protein FEBS Letters  2000 470:125-130  DOI:10.1016/s0014-5793(00)01296-5  PMID:10734220
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    • Legge, G. B., Kriwacki, R. W., Chung, J., Hommel, U., Ramage, P., Case, D. A., Dyson, H. J., Wright, P. E. NMR solution structure of the inserted domain of human leukocyte function associated antigen-1 Journal of Molecular Biology  2000 295:1251-1264  DOI:10.1006/jmbi.1999.3409  PMID:10653701
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    • Cavagnero, S., Theriault, Y., Narula, S. S., Dyson, H. J., Wright, P. E. Amide proton hydrogen exchange rates for sperm whale myoglobin obtained from (15)N-(1)H NMR spectra Protein Science  2000 9:186-193  DOI:10.1110/ps.9.1.186  PMID:10739261  PMCID:PMC2144433
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    • Karimi, A., Matsumura, M., Wright, P. E., Dyson, H. J. Characterization of monomeric and dimeric B domain of Staphylococcal protein A Journal of Peptide Research  1999 54:344-352  DOI:10.1034/j.1399-3011.1999.00115.x  PMID:10532240
    • Duggan, B. M., Dyson, H. J., Wright, P. E. Inherent flexibility in a potent inhibitor of blood coagulation, recombinant nematode anticoagulant protein c2 European Journal of Biochemistry  1999 265:539-548  DOI:10.1046/j.1432-1327.1999.00781.x  PMID:10504384
    • Atkins, A. R., Osborne, M. J., Lashuel, H. A., Edelman, G. M., Wright, P. E., Cunningham, B. A., Dyson, H. J. Association between the first two immunoglobulin-like domains of the neural cell adhesion molecule N-CAM FEBS Letters  1999 451:162-168  DOI:10.1016/s0014-5793(99)00554-2  PMID:10371158
    • Radhakrishnan, I., Perez-Alvarado, G. C., Parker, D., Dyson, H. J., Montminy, M. R., Wright, P. E. Structural analyses of CREB-CBP transcriptional activator-coactivator complexes by NMR spectroscopy: implications for mapping the boundaries of structural domains Journal of Molecular Biology  1999 287:859-865  DOI:10.1006/jmbi.1999.2658  PMID:10222196
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    • Holmbeck, S. M. A., Dyson, H. J., Wright, P. E. DNA-induced conformational changes are the basis for cooperative dimerization by the DNA binding domain of the retinoid X receptor Journal of Molecular Biology  1998 284:533-539  DOI:10.1006/jmbi.1998.2207  PMID:9826495
    • Simanek, E. E., Huang, D. H., Pasternack, L., Machajewski, T. D., Seitz, O., Millar, D. S., Dyson, H. J., Wong, C. H. Glycosylation of threonine of the repeating unit of RNA polymerase II with beta-linked N-acetylglucosame leads to a turnlike structure Journal of the American Chemical Society  1998 120:11567-11575  DOI:10.1021/ja982312w
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    • Dillet, V., Dyson, H. J., Bashford, D. Calculations of electrostatic interactions and pK(a)s in the active site of Escherichia coli thioredoxin Biochemistry  1998 37:10298-10306  DOI:10.1021/bi980333x  PMID:9665738
    • Radhakrishnan, I., Perez-Alvarado, G. C., Dyson, H. J., Wright, P. E. Conformational preferences in the Ser(133)-phosphorylated and non-phosphorylated forms of the kinase inducible transactivation domain of CREB FEBS Letters  1998 430:317-322  DOI:10.1016/s0014-5793(98)00680-2  PMID:9688563
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    • Dyson, H. J., Wright, P. E. Equilibrium NMR studies of unfolded and partially folded proteins Nature Structural Biology  1998 5:499-503  DOI:10.1038/739  PMID:9665178
    • Eliezer, D., Yao, J., Dyson, H. J., Wright, P. E. Structural and dynamic characterization of partially folded states of apomyoglobin and implications for protein folding Nature Structural Biology  1998 5:148-155  PMID:9461081
    • Zhu, L. M., Dyson, H. J., Wright, P. E. A NOESY-HSQC simulation program, SPIRIT Journal of Biomolecular NMR  1998 11:17-29  DOI:10.1023/a:1008252526537  PMID:9566311
    • Dyson, H. J., Bolinger, L., Feher, V. A., Osterhout, J. J., Yao, J., Wright, P. E. Sequence requirements for stabilization of a peptide reverse turn in water solution: proline is not essential for stability European Journal of Biochemistry  1998 255:462-471  DOI:10.1046/j.1432-1327.1998.2550462.x  PMID:9716389
    • Yao, J., Dyson, H. J., Wright, P. E. Chemical shift dispersion and secondary structure prediction in unfolded and partly folded proteins FEBS Letters  1997 419:285-289  DOI:10.1016/s0014-5793(97)01474-9  PMID:9428652
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    • Bender, C. J., Casimiro, D. R., Peisach, J., Dyson, H. J. Electron spin echo modulation study of the Type I copper protein rusticyanin and its mutant variant His85Ala: implications for the general analysis of weak (14)N superhyperfine interactions Journal of the Chemical Society-Faraday Transactions  1997 93:3967-3980  DOI:10.1039/a704541g
    • Casimiro, D. R., Wright, P. E., Dyson, H. J. PCR-based gene synthesis and protein NMR spectroscopy Structure  1997 5:1407-1412  DOI:10.1016/s0969-2126(97)00291-8  PMID:9384559
    • Eliezer, D., Jennings, P. A., Dyson, H. J., Wright, P. E. Populating the equilibrium molten globule state of apomyoglobin under conditions suitable for structural characterization by NMR FEBS Letters  1997 417:92-96  DOI:10.1016/s0014-5793(97)01256-8  PMID:9395082
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    • Ghiara, J. B., Ferguson, D. C., Satterthwait, A. C., Dyson, H. J., Wilson, I. A. Structure-based design of a constrained peptide mimic of the HIV-1 V3 loop neutralization site Journal of Molecular Biology  1997 266:31-39  DOI:10.1006/jmbi.1996.0768  PMID:9054968
    • Prytulla, S., Dyson, H. J., Wright, P. E. Gene synthesis, high-level expression and assignment of backbone (15)N and (13)C resonances of soybean leghemoglobin FEBS Letters  1996 399:283-289  DOI:10.1016/s0014-5793(96)01278-1  PMID:8985163
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    • Campbell, A. P., Sykes, B. D., Norrby, E., AssaMunt, N., Dyson, H. J. Solution conformation of an immunogenic peptide derived from the principal neutralizing determinant of the HIV-2 envelope glycoprotein gp125 Folding & Design  1996 1:157-165  DOI:10.1016/s1359-0278(96)00024-7  PMID:9079375
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    • Waltho, J. P., Feher, V. A., Merutka, G., Dyson, H. J., Wright, P. E. Peptide models of protein folding initiation sites. 1. Secondary structure formation by peptides corresponding to the G- and H-helices of myoglobin Biochemistry  1993 32:6337-6347  DOI:10.1021/bi00076a006  PMID:8518279
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    • Nachman, R. J., Roberts, V. A., Dyson, H. J., Holman, G. M., Tainer, J. A. Active conformation of an insect neuropeptide family Proceedings of the National Academy of Sciences of the United States of America  1991 88:4518-4522  DOI:10.1073/pnas.88.10.4518  PMID:2034692
    • Dyson, H. J., Tennant, L. L., Holmgren, A. Proton-transfer effects in the active-site region of Escherichia coli thioredoxin using two-dimensional (1)H NMR Biochemistry  1991 30:4262-4268  DOI:10.1021/bi00231a023  PMID:1850621
    • Oldstone, M. B. A., Tishon, A., Lewicki, H., Dyson, H. J., Feher, V. A., Assamunt, N., Wright, P. E. Mapping the anatomy of the immunodominant domain of the human immunodeficiency virus gp41 transmembrane protein: peptide conformation analysis using monoclonal antibodies and proton nuclear magnetic resonance spectroscopy Journal of Virology  1991 65:1727-1734  PMID:2002540  PMCID:PMC239977
    • Dyson, H. J., Wright, P. E. Defining solution conformations of small linear peptides Annual Review of Biophysics and Biophysical Chemistry  1991 20:519-538  DOI:10.1146/annurev.biophys.20.1.519  PMID:1867725
    • Dyson, H. J., Satterthwait, A. C., Lerner, R. A., Wright, P. E. Conformational preferences of synthetic peptides derived from the immunodominant site of the circumsporozoite protein of Plasmodium falciparum by (1)H NMR Biochemistry  1990 29:7828-7837  DOI:10.1021/bi00486a008  PMID:2261440
    • Wright, P. E., Dyson, H. J., Lerner, R. A., Riechmann, L., Tsang, P. Antigen-antibody interactions: an NMR approach Biochemical Pharmacology  1990 40:83-88  DOI:10.1016/0006-2952(90)90182-k  PMID:1695509
    • Dyson, H. J., Gippert, G. P., Case, D. A., Holmgren, A., Wright, P. E. Three-dimensional solution structure of the reduced form of Escherichia coli thioredoxin determined by nuclear magnetic resonance spectroscopy Biochemistry  1990 29:4129-4136  DOI:10.1021/bi00469a016  PMID:2193685
    • Satterthwait, A. C., Chiang, L. C., Arrhenius, T., Cabezas, E., Zavala, F., Dyson, H. J., Wright, P. E., Lerner, R. A. The conformational restriction of synthetic vaccines for malaria Bulletin of the World Health Organization  1990 68:17-25  PMID:2094582  PMCID:PMC2393045
    • Osterhout, J. J., Baldwin, R. L., York, E. J., Stewart, J. M., Dyson, H. J., Wright, P. E. (1)H NMR studies of the solution conformations of an analog of the C-peptide of ribonuclease A Biochemistry  1989 28:7059-7064  DOI:10.1021/bi00443a042  PMID:2819049
    • Dyson, H. J., Holmgren, A., Wright, P. E. Assignment of the proton NMR spectrum of reduced and oxidized thioredoxin: sequence-specific assignments, secondary structure, and global fold Biochemistry  1989 28:7074-7087  DOI:10.1021/bi00443a044  PMID:2684270
    • Wright, P. E., Dyson, H. J., Lerner, R. A. Conformation of peptide fragments of proteins in aqueous solution: implications for initiation of protein folding Biochemistry  1988 27:7167-7175  DOI:10.1021/bi00419a001  PMID:3061450
    • Dyson, H. J., Holmgren, A., Wright, P. E. Structural differences between oxidized and reduced thioredoxin monitored by two-dimensional (1)H NMR spectroscopy FEBS Letters  1988 228:254-258  DOI:10.1016/0014-5793(88)80010-3  PMID:3277863
    • Dyson, H. J., Rance, M., Houghten, R. A., Lerner, R. A., Wright, P. E. Folding of immunogenic peptide fragments of proteins in water solution. I. Sequence requirements for the formation of a reverse turn Journal of Molecular Biology  1988 201:161-200  DOI:10.1016/0022-2836(88)90446-9  PMID:2843644
    • Dyson, H. J., Rance, M., Houghten, R. A., Wright, P. E., Lerner, R. A. Folding of immunogenic peptide fragments of proteins in water solution. II. The nascent helix Journal of Molecular Biology  1988 201:201-217  DOI:10.1016/0022-2836(88)90447-0  PMID:3418697
    • Dyson, H. J., Lerner, R. A., Wright, P. E. The physical basis for induction of protein-reactive antipeptide antibodies Annual Review of Biophysics and Biophysical Chemistry  1988 17:305-324  DOI:10.1146/annurev.biophys.17.1.305  PMID:2456075
    • Dyson, H. J., Cross, K. J., Ostresh, J., Houghten, R. A., Wilson, I. A., Wright, P. E., Lerner, R. A. Selection by site-directed antibodies of small regions of peptides which are ordered in water Ciba Foundation Symposia  1986 119:58-75  PMID:3525041
    • Dyson, H. J., Cross, K. J., Houghten, R. A., Wilson, I. A., Wright, P. E., Lerner, R. A. The immunodominant site of a synthetic immunogen has a conformational preference in water for a type-II reverse turn Nature  1985 318:480-483  PMID:4069219
    • Dyson, H. J., Beattie, J. K. Spin state and unfolding equilibria of ferricytochrome c in acidic solutions Journal of Biological Chemistry  1982 257:2267-2273  PMID:6277891
    • Upcroft, P., Dyson, H. J., Wake, R. G. Characteristics of a Bacillus subtilis W23 mutant temperature sensitive for initiation of chromosome replication Journal of Bacteriology  1975 121:121-127  PMID:803947  PMCID:PMC285621
  • thesis

    • Dyson, H. J. How do proteins work? 2008
    • Dyson, H. J. Dynamic and equilibrium spectrophotometry of hemoproteins 1977

featured in

  • Faculty Promotions Announced (October 1, 2001)  Newsletter
  • Scripps Research Institute Study Finds New Moves in Protein's Evolution  News Release
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Research

research overview

  • NMR is the method of choice in studying unfolded proteins, as well as proteins such as the prion protein that have highly unstructured parts. Since many of the entries in the published genomes appear to code for proteins that should be intrinsically unstructured, an understanding of the nature and behavior of unfolded proteins is assuming increasing importance.

    Studies with unfolded and partly folded forms of proteins have given us important insights into the earliest steps in the protein folding process. A series of forms of the helical protein apomyoglobin, modeling various stages in the folding process, have now been fully characterized. Using NMR and other spectroscopic techniques, we have been able to map the progressive compaction and increasing structure formation that occurs as the protein folds. A series of mutant proteins has provided important, sometimes surprising, details of the folding process at the level of individual amino acid residues.

    Probing the mechanism of action of enzymes using NMR techniques that give information on local motion in the polypeptide chain has given us important insights into the role of dynamics in enzyme action. We have studied several systems, including the clinically important antibiotic-resistance enzyme metallo-b-lactamase from Bacteroides fragilis andEscherichia coli thioredoxin. Structure-function studies are particularly focused on the role of polypeptide chain dynamics in a number of systems that appear to use thiol-disulfide chemistry to control cellular processes.
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Teaching

advisees

  • graduate advising relationship

    • Tuttle, Lisa, Ph.D.  candidate, 2006 - 2012
    • Bhabha, Gira Sorab, Ph.D.  candidate, 2007 - 2011
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Background

education and training

  • D.Sc., The University of Sydney , Faculty of Science 2007
  • Ph.D. in Inorganic Chemistry, The University of Sydney 1977
  • B.Sc. in Biochemistry, The University of Sydney , Hons, Class 1 1973

awards and honors

  • ISMAR Prize, conferred by International Society of Magnetic Resonance , 2019
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Contact

full name

  • H. Jane Dyson

geographic location

  • Scripps California 
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Identity

ORCID iD

  • ORCID iD http://orcid.org/0000-0001-6855-3398

Scopus ID

  • 7102413157

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