Dyson, Jane

Faculty Member

Positions

2013 - Professor, Integrative Structural and Computational Biology (ISCB) , Scripps Research
1984 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
1984 - 2012 Professor, Molecular Biology , Scripps Research

Dr. Helen Jane Dyson uses NMR to study the protein-folding process and to study the nature and behavior of unfolded and partly folded forms of proteins, including prion proteins and several newly-discovered, intrinsically unstructured proteins.

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dyson@scripps.edu

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academic article
- Singh, J. K., Hutt, D. M., Tait, B., Guy, N. C., Sivils, J. C., Ortiz, N. R., Payan, A. N., Komaragiri, S. K., Owens, J. J., Culbertson, D., Blair, L. J., Dickey, C., et al. Management of Hsp90-dependent protein folding by small molecules targeting the Aha1 co-chaperone Cell Chemical Biology 2020 27:292-305 DOI:10.1016/j.chembiol.2020.01.008 PMID:32017918 PMCID:PMC7144688
- Singh, A., Dyson, H. J. Backbone and side-chain chemical shift assignments of p50 subunit of NF-κB transcription factor Biomolecular Nmr Assignments 2020 DOI:10.1007/s12104-020-09978-z PMID:32936430
- Dyson, H. J. Reflections on the Pandemic Biophysical Journal 2020 119:E1-E1 DOI:10.1016/j.bpj.2020.07.018 PMID:32771077 PMCID:PMC7414318
- Aoto, P. C., Stanfield, R. L., Wilson, I. A., Dyson, H. J., Wright, P. E. A dynamic switch in inactive p38γ leads to an excited state on the pathway to an active kinase Biochemistry 2019 58:5160-5172 DOI:10.1021/acs.biochem.9b00932 PMID:31794659 PMCID:PMC6932632
- Dyson, H. J., Wright, P. E. Perspective: the essential role of NMR in the discovery and characterization of intrinsically disordered proteins Journal of Biomolecular NMR 2019 DOI:10.1007/s10858-019-00280-2 PMID:31617035
- Wu, H., Dyson, H. J. Aggregation of zinc-free p53 is inhibited by Hsp90 but not other chaperones Protein Science 2019 DOI:10.1002/pro.3726 PMID:31503385
- Berlow, R. B., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Role of backbone dynamics in modulating the interactions of disordered ligands with the TAZ1 domain of the CREB-binding protein Biochemistry 2019 58:1354-1362 DOI:10.1021/acs.biochem.8b01290 PMID:30775911 PMCID:PMC6414276
- Dyson, J. A journal for all biophysics Biophysical Journal 2019 116:E1-E1 DOI:10.1016/j.bpj.2018.12.001 PMID:30553436
- Sung, X., Jaeger, M., Kelly, J. W., Dyson, J. H., Wright, P. E. Mispacking of the Phe87 side chain reduces the kinetic stability of human transthyretin Biochemistry 2018 57:6919-6922 DOI:10.1021/acs.biochem.8b01046 PMID:30540442
- Shnitkind, S., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Structural basis for graded inhibition of CREB:DNA interactions by multi-site phosphorylation Biochemistry 2018 57:6964-6972 DOI:10.1021/acs.biochem.8b01092 PMID:30507144
- Krois, A. S., Dyson, H. J., Wright, P. E. Long-range regulation of p53 DNA binding by its intrinsically disordered N-terminal transactivation domain Proceedings of the National Academy of Sciences of the United States of America 2018 115:E11302-E11310 DOI:10.1073/pnas.1814051115 PMID:30420502 PMCID:PMC6275486
- Yang, K., Stanfield, R. L., Martinez-Yamout, M. A., Dyson, H. J., Wilson, I. A., Wright, P. E. Structural basis for cooperative regulation of KIX-mediated transcription pathways by the HTLV-1 HBZ activation domain Proceedings of the National Academy of Sciences of the United States of America 2018 115:10040-10045 DOI:10.1073/pnas.1810397115 PMID:30232260 PMCID:PMC6176603
- Berlow, R. B., Dyson, H. J., Wright, P. E. Expanding the Paradigm: Intrinsically Disordered Proteins and Allosteric Regulation Journal of Molecular Biology 2018 430:2309-2320 DOI:10.1016/j.jmb.2018.04.003 PMID:29634920 PMCID:PMC6045455
- Leach, B. I., Zhang, X., Kelly, J. W., Dyson, H. J., Wright, P. E. NMR measurements reveal the structural basis of transthyretin destabilization by pathogenic mutations Biochemistry 2018 57:4421-4430 DOI:10.1021/acs.biochem.8b00642 PMID:29972637 PMCID:PMC6067956
- Dyson, H. J., Wright, P. E. How do intrinsically disordered viral proteins hijack the cell? Biochemistry 2018 57:4045-4046 DOI:10.1021/acs.biochem.8b00622 PMID:29952542 PMCID:PMC6054125
- Sun, X., Dyson, H. J., Wright, P. E. Kinetic analysis of the multistep aggregation pathway of human transthyretin Proceedings of the National Academy of Sciences of the United States of America 2018 115:E6201-E6208 DOI:10.1073/pnas.1807024115 PMID:29915031
- Nikolova, E. N., Stanfield, R. L., Dyson, H. J., Wright, P. E. CH···O hydrogen bonds mediate highly specific recognition of methylated CpG sites by the zinc finger protein kaiso Biochemistry 2018 57:2109-2120 DOI:10.1021/acs.biochem.8600065 PMID:29546986 PMCID:PMC5893398
- Dyson, J. Is the BJ review process gender-biased? Biophysical Journal 2018 114:E1-E1 DOI:10.1016/j.bpj.2018.02.007 PMID:29539410 PMCID:PMC5883556
- Wu, H., Hyun, J., Martinez-Yamout, M. A., Park, S. J., Dyson, H. J. Characterization of an Hsp90-Independent Interaction between Co-Chaperone p23 and Transcription Factor p53 Biochemistry 2018 57:935-944 DOI:10.1021/acs.biochem.7b01076 PMID:29334217 PMCID:PMC5811392
- Fenwick, R. B., Oyen, D., Dyson, H. J., Wright, P. E. Slow dynamics of tryptophan-water networks in proteins Journal of the American Chemical Society 2018 140:675-682 DOI:10.1021/jacs.7b09974 PMID:29256600 PMCID:PMC5771866
- Sun, X., Dyson, H. J., Wright, P. E. Fluorotryptophan incorporation modulates the structure and stability of transthyretin in a site-specific manner Biochemistry 2017 56:5570-5581 DOI:10.1021/acs.biochem.7b00815 PMID:28920433 PMCID:PMC5645263
- Oyen, D., Fenwick, R. B., Aoto, P. C., Stanfield, R. L., Wilson, I. A., Dyson, H. J., Wright, P. E. Defining the structural basis for allosteric product release from E. coli dihydrofolate reductase using NMR relaxation dispersion Journal of the American Chemical Society 2017 139:11233-11240 DOI:10.1021/jacs.7b05958 PMID:28737940 PMCID:PMC5562155
- Park, S., Phukan, P. D., Zeeb, M., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Structural basis for interaction of the tandem zinc finger domains of human muscleblind with cognate RNA from human cardiac troponin T Biochemistry 2017 56:4154-4168 DOI:10.1021/acs.biochem.7b00484 PMID:28718627 PMCID:PMC5560242
- Berlow, R. B., Dyson, H. J., Wright, P. E. Hypersensitive termination of the hypoxic response by a disordered protein switch Nature 2017 543:447-451 DOI:10.1038/nature21705 PMID:28273070 PMCID:PMC5375031
- Dembinski, H. E., Wismer, K., Vargas, J. D., Suryawanshi, G. W., Kern, N., Kroon, G., Dyson, H. J., Hoffmann, A., Komives, E. A. Functional importance of stripping in NFκB signaling revealed by a stripping-impaired IκBα mutant Proceedings of the National Academy of Sciences of the United States of America 2017 114:1916-1921 DOI:10.1073/pnas.1610192114 PMID:28167786 PMCID:PMC5338396
- Dyson, H. J., Wright, P. E. How does your protein fold? Elucidating the apomyoglobin folding pathway Accounts of Chemical Research 2017 50:105-111 DOI:10.1021/acs.accounts.6b00511 PMID:28032989 PMCID:PMC5241236
- Haberz, P., Arai, M., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Mapping the interactions of adenoviral E1A proteins with the p160 nuclear receptor coactivator binding domain of CBP Protein Science 2016 25:2256-2267 DOI:10.1002/pro.3059 PMID:27699893 PMCID:PMC5119557
- Bhowmick, A., Brookes, D. H., Yost, S. R., Dyson, H. J., Forman-Kay, J. D., Gunter, D., Head-Gordon, M., Hura, G. L., Pande, V. S., Wemmer, D. E., Wright, P. E., Head-Gordon, T. Finding our way in the dark proteome Journal of the American Chemical Society 2016 138:9730-9742 DOI:10.1021/jacs.6b06543 PMID:27387657 PMCID:PMC5051545
- Hsu, C. H., Park, S., Mortenson, D. E., Foley, B. L., Wang, X., Woods, R. J., Case, D. A., Powers, E. T., Wong, C. H., Dyson, H. J., Kelly, J. W. The dependence of carbohydrate-aromatic interaction strengths on the structure of the carbohydrate Journal of the American Chemical Society 2016 138:7636-7648 DOI:10.1021/jacs.6b02879 PMID:27249581 PMCID:PMC4924591
- Mukherjee, S. P., Quintas, P. O., McNulty, R., Komives, E. A., Dyson, H. J. Structural characterization of the ternary complex that mediates termination of NF-κB signaling by IκBα Proceedings of the National Academy of Sciences of the United States of America 2016 113:6212-6217 DOI:10.1073/pnas.1603488113 PMID:27185953 PMCID:PMC4896678
- Krois, A. S., Ferreon, J. C., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein Proceedings of the National Academy of Sciences of the United States of America 2016 113:E1853-E1862 DOI:10.1073/pnas.1602487113 PMID:26976603 PMCID:PMC4822595
- Dyson, H. J., Wright, P. E. Role of intrinsic protein disorder in the function and interactions of the transcriptional coactivators CREB-binding protein (CBP) and p300 Journal of Biological Chemistry 2016 291:6714-6722 DOI:10.1074/jbc.R115.692020 PMID:26851278 PMCID:PMC4807259
- Dyson, H. J. Making sense of intrinsically disordered proteins Biophysical Journal 2016 110:1013-1016 DOI:10.1016/j.bpj.2016.01.030 PMID:26958875 PMCID:PMC4788759
- Mukherjee, S. P., Borin, B., Quintas, P. O., Dyson, H. J. NMR characterization of a 72 kDa transcription factor using differential isotopic labeling Protein Science 2016 25:597-604 DOI:10.1002/pro.2853 PMID:26647230 PMCID:PMC4815403
- Fenwick, R. B., Dyson, H. J. Classic analysis of biopolymer dynamics is model free Biophysical Journal 2016 110:3-6 DOI:10.1016/j.bpj.2015.11.022 PMID:26745403 PMCID:PMC4805862
- Keskin, O., Dyson, H. J., Bahar, I. Biomolecular systems interactions, dynamics, and allostery: reflections and new directions Biophysical Journal 2015 109:E01-E02 DOI:10.1016/j.bpj.2015.08.005 PMID:26377787 PMCID:PMC4576319
- Berlow, R. B., Dyson, H. J., Wright, P. E. Functional advantages of dynamic protein disorder FEBS Letters 2015 589:2433-2440 DOI:10.1016/j.febslet.2015.06.003 PMID:26073260 PMCID:PMC4586362
- Arai, M., Sugase, K., Dyson, H. J., Wright, P. E. Conformational propensities of intrinsically disordered proteins influence the mechanism of binding and folding Proceedings of the National Academy of Sciences of the United States of America 2015 112:9614-9619 DOI:10.1073/pnas.1512799112 PMID:26195786 PMCID:PMC4534220
- Oyen, D., Fenwick, R. B., Stanfield, R. L., Dyson, H. J., Wright, P. E. Cofactor-mediated conformational dynamics promote product release from Escherichia coli dihydrofolate reductase via an allosteric pathway Journal of the American Chemical Society 2015 137:9459-9468 DOI:10.1021/jacs.5b05707 PMID:26147643 PMCID:PMC4521799
- Wright, P. E., Dyson, H. J. Intrinsically disordered proteins in cellular signalling and regulation Nature Reviews Molecular Cell Biology 2015 16:18-29 DOI:10.1038/nrm3920 PMID:25531225 PMCID:PMC4405151
- Jansma, A. L., Martinez-Yamout, M. A., Liao, R., Sun, P., Dyson, H. J., Wright, P. E. The high-risk HPV16 E7 oncoprotein mediates interaction between the transcriptional coactivator CBP and the retinoblastoma protein pRb Journal of Molecular Biology 2014 426:4030-4048 DOI:10.1016/j.jmb.2014.10.021 PMID:25451029 PMCID:PMC4258470
- Aoto, P. C., Nishimura, C., Dyson, H. J., Wright, P. E. Probing the non-native H helix translocation in apomyoglobin folding intermediates Biochemistry 2014 53:3767-3780 DOI:10.1021/bi500478m PMID:24857522 PMCID:PMC4067146
- Burge, R. G., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Structural characterization of interactions between the double-stranded RNA-binding zinc finger protein JAZ and nucleic acids Biochemistry 2014 53:1495-1510 DOI:10.1021/bi401675h PMID:24521053 PMCID:PMC3985865
- Tuttle, L. M., Dyson, H. J., Wright, P. E. Side chain conformational averaging in human dihydrofolate reductase Biochemistry 2014 53:1134-1145 DOI:10.1021/bi4015314 PMID:24498949 PMCID:PMC3985697
- Bhabha, G., Ekiert, D. C., Jennewein, M., Zmasek, C. M., Tuttle, L. M., Kroon, G., Dyson, H. J., Godzik, A., Wilson, I. A., Wright, P. E. Divergent evolution of protein conformational dynamics in dihydrofolate reductase Nature Structural & Molecular Biology 2013 20:1243-1249 DOI:10.1038/nsmb.2676 PMID:24077226 PMCID:PMC3823643
- Park, S., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. The CH2 domain of CBP/p300 is a novel zinc finger FEBS Letters 2013 587:2506-2511 DOI:10.1016/j.febslet.2013.06.051 PMID:23831576 PMCID:PMC3765250
- Boehr, D. D., Schnell, J. R., McElheny, D., Bae, S. H., Duggan, B. M., Benkovic, S. J., Dyson, H. J., Wright, P. E. A distal mutation perturbs dynamic amino acid networks in dihydrofolate reductase Biochemistry 2013 52:4605-4619 DOI:10.1021/bi400563c PMID:23758161 PMCID:PMC3838469
- Chen, W., Enck, S., Price, J. L., Powers, D. L., Powers, E. T., Wong, C. H., Dyson, H. J., Kelly, J. W. Structural and energetic basis of carbohydrate-aromatic packing interactions in proteins Journal of the American Chemical Society 2013 135:9877-9884 DOI:10.1021/ja4040472 PMID:23742246 PMCID:PMC3715148
- Tuttle, L. M., Dyson, H. J., Wright, P. E. Side-chain conformational heterogeneity of intermediates in the Escherichia coli dihydrofolate reductase catalytic cycle Biochemistry 2013 52:3464-3477 DOI:10.1021/bi400322e PMID:23614825 PMCID:PMC3796204
- Lim, K. H., Dyson, H. J., Kelly, J. W., Wright, P. E. Localized structural fluctuations promote amyloidogenic conformations in transthyretin Journal of Molecular Biology 2013 425:977-988 DOI:10.1016/j.jmb.2013.01.008 PMID:23318953 PMCID:PMC3594634
- Cervantes, C. F., Handley, L. D., Sue, S. C., Dyson, H. J., Komives, E. A. Long-range effects and functional consequences of stabilizing mutations in the ankyrin repeat domain of IκBα Journal of Molecular Biology 2013 425:902-913 DOI:10.1016/j.jmb.2012.12.012 PMID:23274114 PMCID:PMC3744861
- Cardoso, R., Love, R., Nilsson, C. L., Bergqvist, S., Nowlin, D., Yan, J. L., Liu, K. K. C., Zhu, J., Chen, P., Deng, Y. L., Dyson, H. J., Greig, M. J., et al. Identification of cys255 in hif-1 alpha as a novel site for development of covalent inhibitors of hif-1 alpha/arnt pasb domain protein-protein interaction Protein Science 2012 21:1885-1896 DOI:10.1002/pro.2172 PMID:23033253 PMCID:PMC3575918
- Vila, J. A., Sue, S. C., Fraser, J. S., Scheraga, H. A., Dyson, H. J. Cheshift-2 resolves a local inconsistency between two x-ray crystal structures Journal of Biomolecular NMR 2012 54:193-198 DOI:10.1007/s10858-012-9663-0 PMID:22945426 PMCID:PMC3471536
- Buck-Koehntop, B. A., Stanfield, R. L., Ekiert, D. C., Martinez-Yamout, M. A., Dyson, H. J., Wilson, I. A., Wright, P. E. Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein kaiso Proceedings of the National Academy of Sciences of the United States of America 2012 109:15229-15234 DOI:10.1073/pnas.1213726109 PMID:22949637 PMCID:PMC3458336
- Zhu, J., Martinez-Yamout, M., Cardoso, R., Yan, J. L., Love, R. A., Grodsky, N., Brooun, A., Dyson, H. J. Homodimerization of the PAS-B domains of hypoxia-inducible factors Journal of Physical Chemistry B 2012 116:6960-6965 DOI:10.1021/jp300525n PMID:22424208 PMCID:PMC3376167
- Dyson, H. J., Komives, E. A. Role of disorder in i?B-nf?B interaction IUBMB Life 2012 64:499-505 DOI:10.1002/iub.1044 PMID:22573609 PMCID:PMC3575514
- Buck-Koehntop, B. A., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Kaiso uses all three zinc fingers and adjacent sequence motifs for high affinity binding to sequence-specific and methyl-cpg DNA targets FEBS Letters 2012 586:734-739 DOI:10.1016/j.febslet.2012.01.045 PMID:22300642 PMCID:PMC3309074
- Dyson, H. J. Roles of intrinsic disorder in protein-nucleic acid interactions Molecular Biosystems 2012 8:97-104 DOI:10.1039/c1mb05258f PMID:21874205 PMCID:PMC3600845
- Dyson, H. J. Expanding the proteome: Disordered and alternatively folded proteins Quarterly Reviews of Biophysics 2011 44:467-518 DOI:10.1017/s0033583511000060 PMID:21729349 PMCID:PMC3189428
- Nishimura, C., Dyson, H. J., Wright, P. E. Consequences of stabilizing the natively disordered f helix for the folding pathway of apomyoglobin Journal of Molecular Biology 2011 411:248-263 DOI:10.1016/j.jmb.2011.05.028 PMID:21640124 PMCID:PMC3143293
- Park, S. J., Kostic, M., Dyson, H. J. Dynamic interaction of hsp90 with its client protein p53 Journal of Molecular Biology 2011 411:158-173 DOI:10.1016/j.jmb.2011.05.030 PMID:21658391 PMCID:PMC3143201
- Park, S. J., Borin, B. N., Martinez-Yamout, M. A., Dyson, H. J. The client protein p53 adopts a molten globule-like state in the presence of hsp90 Nature Structural & Molecular Biology 2011 18:537-541 DOI:10.1038/nsmb.2045 PMID:21460846 PMCID:PMC3087862
- Bhabha, G., Lee, J., Ekiert, D. C., Gam, J., Wilson, I. A., Dyson, H. J., Benkovic, S. J., Wright, P. E. A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis Science 2011 332:234-238 DOI:10.1126/science.1198542 PMID:21474759 PMCID:PMC3151171
- Sue, S. C., Alverdi, V., Komives, E. A., Dyson, H. J. Detection of a ternary complex of nf-kappa b and i kappa b alpha with DNA provides insights into how i kappa b alpha removes nf-kappa b from transcription sites Proceedings of the National Academy of Sciences of the United States of America 2011 108:1367-1372 DOI:10.1073/pnas.1014323108 PMID:21220295 PMCID:PMC3029698
- Cervantes, C. F., Bergqvist, S., Kjaergaard, M., Kroon, G., Sue, S. C., Dyson, H. J., Komives, E. A. The rela nuclear localization signal folds upon binding to i kappa b alpha Journal of Molecular Biology 2011 405:754-764 DOI:10.1016/j.jmb.2010.10.055 PMID:21094161 PMCID:PMC3056351
- Lee, C. W., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Structure of the p53 transactivation domain in complex with the nuclear receptor coactivator binding domain of creb binding protein Biochemistry 2010 49:9964-9971 DOI:10.1021/bi1012996 PMID:20961098 PMCID:PMC2982890
- Arai, M., Dyson, H. J., Wright, P. E. Leu628 of the kix domain of cbp is a key residue for the interaction with the mll transactivation domain FEBS Letters 2010 584:4500-4504 DOI:10.1016/j.febslet.2010.10.024 PMID:20969867 PMCID:PMC2993637
- Nishimura, C., Dyson, H. J., Wright, P. E. Energetic frustration of apomyoglobin folding: Role of the b helix Journal of Molecular Biology 2010 396:1319-1328 DOI:10.1016/j.jmb.2009.12.040 PMID:20043917 PMCID:PMC2827033
- Boehr, D. D., McElheny, D., Dyson, H. J., Wright, P. E. Millisecond timescale fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands Proceedings of the National Academy of Sciences of the United States of America 2010 107:1373-1378 DOI:10.1073/pnas.0914163107 PMID:20080605 PMCID:PMC2824364
- Bae, S. H., Legname, G., Serban, A., Prusiner, S. B., Wright, P. E., Dyson, H. J. Prion proteins with pathogenic and protective mutations show similar structure and dynamics Biochemistry 2009 48:8120-8128 DOI:10.1021/bi900923b PMID:19618915 PMCID:PMC2762478
- Cervantes, C. F., Markwick, P. R. L., Sue, S. C., McCammon, J. A., Dyson, H. J., Komives, E. A. Functional dynamics of the folded ankyrin repeats of i kappa b alpha revealed by nuclear magnetic resonance Biochemistry 2009 48:8023-8031 DOI:10.1021/bi900712r PMID:19591507 PMCID:PMC2728578
- Ferreon, J. C., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Structural basis for subversion of cellular control mechanisms by the adenoviral e1a oncoprotein Proceedings of the National Academy of Sciences of the United States of America 2009 106:13260-13265 DOI:10.1073/pnas.0906770106 PMID:19651603 PMCID:PMC2726373
- Fuller, A. A., Du, D., Liu, F., Davoren, J. E., Bhabha, G., Kroon, G., Case, D. A., Dyson, H. J., Powers, E. T., Wipf, P., Gruebele, M., Kelly, J. W. Evaluating beta-turn mimics as beta-sheet folding nucleators Proceedings of the National Academy of Sciences of the United States of America 2009 106:11067-11072 DOI:10.1073/pnas.0813012106 PMID:19541614 PMCID:PMC2708776
- Bae, S. H., Dyson, H. J., Wright, P. E. Prediction of the rotational tumbling time for proteins with disordered segments Journal of the American Chemical Society 2009 131:6814-6821 DOI:10.1021/ja809687r PMID:19391622 PMCID:PMC2694746
- Sue, S. C., Dyson, H. J. Interaction of the i kappa b alpha c-terminal pest sequence with nf-kappa b: Insights into the inhibition of nf-kappa b DNA binding by i kappa b alpha Journal of Molecular Biology 2009 388:824-838 DOI:10.1016/j.jmb.2009.03.048 PMID:19327364 PMCID:PMC2688455
- Ferreon, J. C., Lee, C. W., Arai, M., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Cooperative regulation of p53 by modulation of ternary complex formation with cbp/p300 and hdm2 Proceedings of the National Academy of Sciences of the United States of America 2009 106:6591-6596 DOI:10.1073/pnas.0811023106 PMID:19357310 PMCID:PMC2672497
- Wojciak, J. M., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Structural basis for recruitment of cbp/p300 coactivators by stat1 and stat2 transactivation domains EMBO Journal 2009 28:948-958 DOI:10.1038/emboj.2009.30 PMID:19214187 PMCID:PMC2670858
- Lee, C. W., Arai, M., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Mapping the interactions of the p53 transactivation domain with the kix domain of cbp Biochemistry 2009 48:2115-2124 DOI:10.1021/bi802055v PMID:19220000 PMCID:PMC2765525
- Wright, P. E., Dyson, H. J. Linking folding and binding Current Opinion in Structural Biology 2009 19:31-38 DOI:10.1016/j.sbi.2008.12.003 PMID:19157855 PMCID:PMC2675572
- Danielsson, J., Liljedahl, L., Barany-Wallje, E., Sonderby, P., Kristensen, L. H., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E., Poulsen, F. M., Maler, L., Graslund, A., Kragelund, B. B. The intrinsically disordered rnr inhibitor sml1 is a dynamic dimer Biochemistry 2008 47:13428-13437 DOI:10.1021/bi801040b PMID:19086274 PMCID:PMC2747730
- Yonemoto, I. T., Kroon, G. J. A., Dyson, H. J., Balch, W. E., Kelly, J. W. Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state Biochemistry 2008 47:9900-9910 DOI:10.1021/bi800828u PMID:18710262 PMCID:PMC2662778
- Uzawa, T., Nishimura, C., Akiyama, S., Ishimori, K., Takahashi, S., Dyson, H. J., Wright, P. E. Hierarchical folding mechanism of apomyoglobin revealed by ultra-fast h/d exchange coupled with 2d NMR Proceedings of the National Academy of Sciences of the United States of America 2008 105:13859-13864 DOI:10.1073/pnas.0804033105 PMID:18779573 PMCID:PMC2544544
- Boehr, D. D., Dyson, H. J., Wright, P. E. Conformational relaxation following hydride transfer plays a limiting role in dihydrofolate reductase catalysis Biochemistry 2008 47:9227-9233 DOI:10.1021/bi801102e PMID:18690714 PMCID:PMC2562322
- Sue, S. C., Cervantes, C., Komives, E. A., Dyson, H. J. Transfer of flexibility between ankyrin repeats in i kappa b alpha upon formation of the nf-kappa b complex Journal of Molecular Biology 2008 380:917-931 DOI:10.1016/j.jmb.2008.05.048 PMID:18565540 PMCID:PMC2603615
- Nishimura, C., Dyson, H. J., Wright, P. E. The kinetic and equilibrium molten globule intermediates of apoleghemoglobin differ in structure Journal of Molecular Biology 2008 378:715-725 DOI:10.1016/j.jmb.2008.03.025 PMID:18384808 PMCID:PMC2409369
- Dyson, H. J., Kostic, M., Liu, J., Martinez-Yamout, M. A. Hydrogen-deuterium exchange strategy for delineation of contact sites in protein complexes FEBS Letters 2008 582:1495-1500 DOI:10.1016/j.febslet.2008.03.043 PMID:18396165 PMCID:PMC2440508
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- Lee, B. M., Buck-Koehntopt, B. A., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Embryonic neural inducing factor churchill is not a DNA-binding zinc finger protein: Solution structure reveals a solvent-exposed beta-sheet and zinc binuclear cluster Journal of Molecular Biology 2007 371:1274-1289 DOI:10.1016/j.jmb.2007.06.021 PMID:17610897 PMCID:PMC1994575
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- Lee, B. M., Xu, J., Clarkson, B. K., Martinez-Yamout, M. A., Dyson, H. J., Case, D. A., Gottesfeld, J. M., Wright, P. E. Induced fit and "lock and key" recognition of 5s RNA by zinc fingers of transcription factor IIIA Journal of Molecular Biology 2006 357:275-291 DOI:10.1016/j.jmb.2005.12.010 PMID:16405997
- Kamikubo, Y., Kroon, G., Curriden, S. A., Dyson, H. J., Loskutoff, D. J. The reduced, denatured somatomedin B domain of vitronectin refolds into a stable, biologically active molecule Biochemistry 2006 45:3297-3306 DOI:10.1021/bi052278f PMID:16519524
- De Guzman, R. N., Goto, N. K., Dyson, H. J., Wright, P. E. Structural basis for cooperative transcription factor binding to the cbp coactivator Journal of Molecular Biology 2006 355:1005-1013 DOI:10.1016/j.jmb.2005.09.059 PMID:16253272
- Yao, Y., Martinez-Yamout, M. A., Dickerson, T. J., Brogan, A. P., Wright, P. E., Dyson, H. J. Structure of the Escherichia coli quorum sensing protein SdiA: Activation of the folding switch by acyl homoserine lactones Journal of Molecular Biology 2006 355:262-273 DOI:10.1016/j.jmb.2005.10.041 PMID:16307757
- Papadopoulos, E., Oglecka, K., Maler, L., Jarvet, J., Wright, P. E., Dyson, H. J., Graslund, A. Nmr solution structure of the peptide fragment 1-30, derived from unprocessed mouse doppel protein, in dhpc micelles Biochemistry 2006 45:159-166 DOI:10.1021/bi051313f PMID:16388591
- Nishimura, C., Dyson, H. J., Wright, P. E. Identification of native and non-native structure in kinetic folding intermediates of apomyoglobin Journal of Molecular Biology 2006 355:139-156 DOI:10.1016/j.jmb.2005.10.047 PMID:16300787
- Moller, H. M., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Solution structure of the n-terminal zinc fingers of the xenopus laevis double-stranded rna-binding protein zfa Journal of Molecular Biology 2005 351:718-730 DOI:10.1016/j.jmb.2005.06.032 PMID:16051273
- Nishimura, C., Lietzow, M. A., Dyson, H. J., Wright, P. E. Sequence determinants of a protein folding pathway Journal of Molecular Biology 2005 351:383-392 DOI:10.1016/j.jmb.2005.06.017 PMID:16005892
- McElheny, D., Schnell, J. R., Lansing, J. C., Dyson, H. J., Wright, P. E. Defining the role of active-site loop fluctuations in dihydrofolate reductase catalysis Proceedings of the National Academy of Sciences of the United States of America 2005 102:5032-5037 DOI:10.1073/pnas.0500699102 PMID:15795383 PMCID:PMC556001
- Yao, Y., Martinez-Yamout, M. A., Dyson, H. J. Letter to the editor: Backbone and side chain h-1, c-13 and n-15 assignments for escherichia coli sdia1-171, the autoinducer-binding domain of a quorum sensing protein Journal of Biomolecular NMR 2005 31:373-374 DOI:10.1007/s10858-005-2470-0 PMID:15929010
- Nishimura, C., Dyson, H. J., Wright, P. E. Enhanced picture of protein-folding intermediates using organic solvents in h/d exchange and quench-flow experiments Proceedings of the National Academy of Sciences of the United States of America 2005 102:4765-4770 DOI:10.1073/pnas.0409538102 PMID:15769860 PMCID:PMC555694
- Dyson, H. J., Wright, P. E. Intrinsically unstructured proteins and their functions Nature Reviews Molecular Cell Biology 2005 6:197-208 DOI:10.1038/nrm1589 PMID:15738986
- De Guzman, R. N., Wojciak, J. M., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Cbp/p300 taz1 domain forms a structured scaffold for ligand binding Biochemistry 2005 44:490-497 DOI:10.1021/bi048161t PMID:15641773
- Chen, J. H., Won, H. S., Im, W. P., Dyson, H. J., Brooks, C. L. Generation of native-like protein structures from limited NMR data, modern force fields and advanced conformational sampling Journal of Biomolecular NMR 2005 31:59-64 DOI:10.1007/s10858-004-6056-z PMID:15692739
- Venkitakrishnan, R. P., Zaborowski, E., McElheny, D., Benkovic, S. J., Dyson, H. J., Wright, P. E. Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle Biochemistry 2004 43:16046-16055 DOI:10.1021/bi048119y PMID:15609999
- Legge, G. B., Martinez-Yamout, M. A., Hambly, D. M., Trinh, T., Lee, B. M., Dyson, H. J., Wright, P. E. Zz domain of cbp: An unusual zinc finger fold in a protein interaction module Journal of Molecular Biology 2004 343:1081-1093 DOI:10.1016/j.jmb.2004.08.087 PMID:15476823
- Won, H. S., Low, L. Y., De Guzman, R., Martinez-Yamout, M., Jakob, U., Dyson, H. J. The zinc-dependent redox switch domain of the chaperone hsp33 has a novel fold Journal of Molecular Biology 2004 341:893-899 DOI:10.1016/j.jmb.2004.06.046 PMID:15328602
- Matt, T., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. The cbp/p300 taz1 domain in its native state is not a binding partner of mdm2 Biochemical Journal 2004 381:685-691 DOI:10.1042/bj20040564 PMID:15154850
- Dyson, H. J., Wright, P. E. Unfolded proteins and protein folding studied by NMR Chemical Reviews 2004 104:3607-3622 DOI:10.1021/cr030403s PMID:15303830
- Mohana-Borges, R., Goto, N. K., Kroon, G. J. A., Dyson, H. J., Wright, P. E. Structural characterization of unfolded states of apomyoglobin using residual dipolar couplings Journal of Molecular Biology 2004 340:1131-1142 DOI:10.1016/j.jmb.2004.05.022 PMID:15236972
- Love, J. J., Li, X., Chung, J., Dyson, H. J., Wright, P. E. The lef-1 high-mobility group domain undergoes a disorder-to-order transition upon formation of a complex with cognate DNA Biochemistry 2004 43:8725-8734 DOI:10.1021/bi049591m PMID:15236581
- Kamikubo, Y., De Guzman, R., Kroon, G., Curriden, S., Neels, J. G., Churchill, M. J., Dawson, P., Oldziej, S., Jagielska, A., Scheraga, H. A., Loskutoff, D. J., Dyson, H. J. Disulfide bonding arrangements in active forms of the somatomedin B domain of human vitronectin Biochemistry 2004 43:6519-6534 DOI:10.1021/bi049647c PMID:15157085
- Graf, P. C. F., Martinez-Yamout, M., VanHaerents, S., Lilie, H., Dyson, H. J., Jakob, U. Activation of the redox-regulated chaperone hsp33 by domain unfolding Journal of Biological Chemistry 2004 279:20529-20538 DOI:10.1074/jbc.M401764200 PMID:15023991
- Zor, T., De Guzman, R. N., Dyson, H. J., Wright, P. E. Solution structure of the kix domain of cbp bound to the transactivation domain of c-myb Journal of Molecular Biology 2004 337:521-534 DOI:10.1016/j.jmb.2004.01.038 PMID:15019774
- Hudson, B. P., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Recognition of the mrna au-rich element by the zinc finger domain of tis11d Nature Structural & Molecular Biology 2004 11:257-264 DOI:10.1038/nsmb738 PMID:14981510
- De Guzman, R. N., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Interaction of the taz1 domain of the creb-binding protein with the activation domain of cited2 - regulation by competition between intrinsically unstructured ligands for non-identical binding sites Journal of Biological Chemistry 2004 279:3042-3049 DOI:10.1074/jbc.M310348200 PMID:14594809
- Schnell, J. R., Dyson, H. J., Wright, P. E. Effect of cofactor binding and loop conformation on side chain methyl dynamics in dihydrofolate reductase Biochemistry 2004 43:374-383 DOI:10.1021/bi035464z PMID:14717591
- Demarest, S. J., Deechongkit, S., Dyson, H. J., Evans, R. M., Wright, P. E. Packing, specificity, and mutability at the binding interface between the p160 coactivator and creb-binding protein Protein Science 2004 13:203-210 DOI:10.1110/ps.03366504 PMID:14691235 PMCID:PMC2286511
- Schnell, J. R., Dyson, H. J., Wright, P. E. Structure, dynamics, and catalytic function of dihydrofolate reductase Annual Review of Biophysics and Biomolecular Structure 2004 33:119-140 DOI:10.1146/annurev.biophys.33.110502.133613 PMID:15139807
- Nishimura, C., Wright, P. E., Dyson, H. J. Role of the b helix in early folding events in apomyoglobin: Evidence from site-directed mutagenesis for native-like long range interactions Journal of Molecular Biology 2003 334:293-307 DOI:10.1016/j.jmb.2003.09.042 PMID:14607120
- Osborne, M. J., Venkitakrishnan, R. P., Dyson, H. J., Wright, P. E. Diagnostic chemical shift markers for loop conformation and substrate and cofactor binding in dihydrofolate reductase complexes Protein Science 2003 12:2230-2238 DOI:10.1110/ps.03219603 PMID:14500880 PMCID:PMC2366930
- Kroon, G. J. A., Mo, H. P., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Changes in structure and dynamics of the fv fragment of a catalytic antibody upon binding of inhibitor Protein Science 2003 12:1386-1394 DOI:10.1110/ps.0243303 PMID:12824485 PMCID:PMC2323930
- Huntley, J. J. A., Fast, W., Benkovic, S. J., Wright, P. E., Dyson, H. J. Role of a solvent-exposed tryptophan in the recognition and binding of antibiotic substrates for a metallo-beta-lactamase Protein Science 2003 12:1368-1375 DOI:10.1110/ps.0305303 PMID:12824483 PMCID:PMC2323931
- Perez-Alvarado, G. C., Martinez-Yamout, M., Allen, M. M., Grosschedl, R., Dyson, H. J., Wright, P. E. Structure of the nuclear factor aly: Insights into post-transcriptional regulatory and mrna nuclear export processes Biochemistry 2003 42:7348-7357 DOI:10.1021/bi034062o PMID:12809490
- Mizuguchi, M., Kroon, G. J., Wright, P. E., Dyson, H. J. Folding of a beta-sheet protein monitored by real-time NMR spectroscopy Journal of Molecular Biology 2003 328:1161-1171 DOI:10.1016/s0022-2836(03)00349-8 PMID:12729749
- Lehmann, T. E., Kroon, G., Dyson, H. J., Lorenzo, M. A., Bermudez, H., Perez, H. Plasmodium vivax cs peptides display conformational preferences for folded forms in solution Journal of Peptide Research 2003 61:252-262 DOI:10.1034/j.1399-3011.2003.00055.x PMID:12662359
- Gearhart, M. D., Holmbeck, S. M. A., Evans, R. M., Dyson, H. J., Wright, P. E. Monomeric complex of human orphan estrogen related receptor-2 with DNA: A pseudo-dimer interface mediates extended half-site recognition Journal of Molecular Biology 2003 327:819-832 DOI:10.1016/s0022-2836(03)00183-9 PMID:12654265
- Goto, N. K., Zor, T., Martinez-Yamout, M., Dyson, H. J., Wright, P. E. Cooperativity in transcription factor binding to the coactivator creb-binding protein (cbp) - the mixed lineage leukemia protein (mll) activation domain binds to an allosteric site on the kix domain Journal of Biological Chemistry 2002 277:43168-43174 DOI:10.1074/jbc.M207660200 PMID:12205094
- Zor, T., Mayr, B. M., Dyson, H. J., Montminy, M. R., Wright, P. E. Roles of phosphorylation and helix propensity in the binding of the kix domain of creb-binding protein by constitutive (c-myb) and inducible (creb) activators Journal of Biological Chemistry 2002 277:42241-42248 DOI:10.1074/jbc.M207361200 PMID:12196545
- Schwarzinger, S., Wright, P. E., Dyson, H. J. Molecular hinges in protein folding: The urea-denatured state of apomyoglobin Biochemistry 2002 41:12681-12686 DOI:10.1021/bi020381o PMID:12379110
- Lietzow, M. A., Jamin, M., Dyson, H. J., Wright, P. E. Mapping long-range contacts in a highly unfolded protein Journal of Molecular Biology 2002 322:655-662 DOI:10.1016/s.0022-2836(02)00847-1 PMID:12270702
- Nishimura, C., Dyson, H. J., Wright, P. E. The apomyoglobin folding pathway revisited: Structural heterogeneity in the kinetic burst phase intermediate Journal of Molecular Biology 2002 322:483-489 DOI:10.1016/s0022-2836(02)00810-0 PMID:12225742
- Dames, S. A., Martinez-Yamout, M., De Guzman, R. N., Dyson, H. J., Wright, P. E. Structural basis for hif-1 alpha/cbp recognition in the cellular hypoxic response Proceedings of the National Academy of Sciences of the United States of America 2002 99:5271-5276 DOI:10.1073/pnas.082121399 PMID:11959977 PMCID:PMC122759
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- Demarest, S. J., Martinez-Yamout, M., Chung, J., Chen, H. W., Xu, W., Dyson, H. J., Evans, R. M., Wright, P. E. Mutual synergistic folding in recruitment of cbp/p300 by p160 nuclear receptor coactivators Nature 2002 415:549-553 DOI:10.1038/415549a PMID:11823864
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- Atkins, A. R., Chung, J., Deechongkit, S. P., Little, E. B., Edelman, G. M., Wright, P. E., Cunningham, B. A., Dyson, H. J. Solution structure of the third immunoglobulin domain of the neural cell adhesion molecule N-CAM: can solution studies define the mechanism of homophilic binding? Journal of Molecular Biology 2001 311:161-172 DOI:10.1006/jmbi.2001.4861 PMID:11469865
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- Bai, Y. W., Chung, J., Dyson, H. J., Wright, P. E. Structural and dynamic characterization of an unfolded state of poplar apo-plastocyanin formed under nondenaturing conditions Protein Science 2001 10:1056-1066 DOI:10.1110/ps.00601 PMID:11316886 PMCID:PMC2374208
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- Mo, H. P., Moore, R. C., Cohen, F. E., Westaway, D., Prusiner, S. B., Wright, P. E., Dyson, H. J. Two different neurodegenerative diseases caused by proteins with similar structures Proceedings of the National Academy of Sciences of the United States of America 2001 98:2352-2357 DOI:10.1073/pnas.051627998 PMID:11226243 PMCID:PMC30142
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- Hudson, B. P., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E. Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain Journal of Molecular Biology 2000 304:355-370 DOI:10.1006/jmbi.2000.4207 PMID:11090279
- Huntley, J. J. A., Scrofani, S. D. B., Osborne, M. J., Wright, P. E., Dyson, H. J. Dynamics of the metallo-beta-lactamase from Bacteroides fragilis in the presence and absence of a tight-binding inhibitor Biochemistry 2000 39:13356-13364 DOI:10.1021/bi001210r PMID:11063572
- Laity, J. H., Dyson, H. J., Wright, P. E. Molecular basis for modulation of biological function by alternate splicing of the Wilms' tumor suppressor protein Proceedings of the National Academy of Sciences of the United States of America 2000 97:11932-11935 DOI:10.1073/pnas.97.22.11932 PMID:11050227 PMCID:PMC17272
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- Legge, G. B., Kriwacki, R. W., Chung, J., Hommel, U., Ramage, P., Case, D. A., Dyson, H. J., Wright, P. E. NMR solution structure of the inserted domain of human leukocyte function associated antigen-1 Journal of Molecular Biology 2000 295:1251-1264 DOI:10.1006/jmbi.1999.3409 PMID:10653701
- Laity, J. H., Dyson, H. J., Wright, P. E. DNA-induced alpha-helix capping in conserved linker sequences is a determinant of binding affinity in Cys(2)-His(2) zinc fingers Journal of Molecular Biology 2000 295:719-727 DOI:10.1006/jmbi.1999.3406 PMID:10656784
- Cavagnero, S., Theriault, Y., Narula, S. S., Dyson, H. J., Wright, P. E. Amide proton hydrogen exchange rates for sperm whale myoglobin obtained from (15)N-(1)H NMR spectra Protein Science 2000 9:186-193 DOI:10.1110/ps.9.1.186 PMID:10739261 PMCID:PMC2144433
- Scrofani, S. D. B., Chung, J., Huntley, J. J. A., Benkovic, S. J., Wright, P. E., Dyson, H. J. NMR characterization of the metallo-beta-lactamase from Bacteroides fragilis and its interaction with a tight-binding inhibitor: role of an active-site loop Biochemistry 1999 38:14507-14514 DOI:10.1021/bi990986t PMID:10545172
- Wright, P. E., Dyson, H. J. Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm Journal of Molecular Biology 1999 293:321-331 DOI:10.1006/jmbi.1999.3110 PMID:10550212
- Karimi, A., Matsumura, M., Wright, P. E., Dyson, H. J. Characterization of monomeric and dimeric B domain of Staphylococcal protein A Journal of Peptide Research 1999 54:344-352 DOI:10.1034/j.1399-3011.1999.00115.x PMID:10532240
- Duggan, B. M., Dyson, H. J., Wright, P. E. Inherent flexibility in a potent inhibitor of blood coagulation, recombinant nematode anticoagulant protein c2 European Journal of Biochemistry 1999 265:539-548 DOI:10.1046/j.1432-1327.1999.00781.x PMID:10504384
- Atkins, A. R., Osborne, M. J., Lashuel, H. A., Edelman, G. M., Wright, P. E., Cunningham, B. A., Dyson, H. J. Association between the first two immunoglobulin-like domains of the neural cell adhesion molecule N-CAM FEBS Letters 1999 451:162-168 DOI:10.1016/s0014-5793(99)00554-2 PMID:10371158
- Radhakrishnan, I., Perez-Alvarado, G. C., Parker, D., Dyson, H. J., Montminy, M. R., Wright, P. E. Structural analyses of CREB-CBP transcriptional activator-coactivator complexes by NMR spectroscopy: implications for mapping the boundaries of structural domains Journal of Molecular Biology 1999 287:859-865 DOI:10.1006/jmbi.1999.2658 PMID:10222196
- Cavagnero, S., Dyson, H. J., Wright, P. E. Improved low pH bicelle system for orienting macromolecules over a wide temperature range Journal of Biomolecular NMR 1999 13:387-391 DOI:10.1023/a:1008360022444 PMID:10353198
- Viles, J. H., Cohen, F. E., Prusiner, S. B., Goodin, D. B., Wright, P. E., Dyson, H. J. Copper binding to the prion protein: structural implications of four identical cooperative binding sites Proceedings of the National Academy of Sciences of the United States of America 1999 96:2042-2047 DOI:10.1073/pnas.96.5.2042 PMID:10051591
- Cavagnero, S., Dyson, H. J., Wright, P. E. Effect of H helix destabilizing mutations on the kinetic and equilibrium folding of apomyoglobin Journal of Molecular Biology 1999 285:269-282 DOI:10.1006/jmbi.1998.2273 PMID:9878405
- Tsui, V., Garcia, C., Cavagnero, S., Siuzdak, G., Dyson, H. J., Wright, P. E. Quench-flow experiments combined with mass spectrometry show apomyoglobin folds through an obligatory intermediate Protein Science 1999 8:45-49 DOI:10.1110/ps.8.1.45 PMID:10210182 PMCID:PMC2144105
- Holmbeck, S. M. A., Dyson, H. J., Wright, P. E. DNA-induced conformational changes are the basis for cooperative dimerization by the DNA binding domain of the retinoid X receptor Journal of Molecular Biology 1998 284:533-539 DOI:10.1006/jmbi.1998.2207 PMID:9826495
- Simanek, E. E., Huang, D. H., Pasternack, L., Machajewski, T. D., Seitz, O., Millar, D. S., Dyson, H. J., Wong, C. H. Glycosylation of threonine of the repeating unit of RNA polymerase II with beta-linked N-acetylglucosame leads to a turnlike structure Journal of the American Chemical Society 1998 120:11567-11575 DOI:10.1021/ja982312w
- Scrofani, S. D. B., Wright, P. E., Dyson, H. J. The identification of metal-binding ligand residues in metalloproteins using nuclear magnetic resonance spectroscopy Protein Science 1998 7:2476-2479 DOI:10.1002/pro.5560071128 PMID:9828017 PMCID:PMC2143851
- Jeng, M. F., Reymond, M. T., Tennant, L. L., Holmgren, A., Dyson, H. J. NMR characterization of a single-cysteine mutant of Escherichia coli thioredoxin and a covalent thioredoxin-peptide complex European Journal of Biochemistry 1998 257:299-308 DOI:10.1046/j.1432-1327.1998.2570299.x PMID:9826174
- Holmbeck, S. M. A., Foster, M. P., Casimiro, D. R., Sem, D. S., Dyson, H. J., Wright, P. E. High-resolution solution structure of the retinoid X receptor DNA-binding domain Journal of Molecular Biology 1998 281:271-284 DOI:10.1006/jmbi.1998.1908 PMID:9698548
- Dillet, V., Dyson, H. J., Bashford, D. Calculations of electrostatic interactions and pK(a)s in the active site of Escherichia coli thioredoxin Biochemistry 1998 37:10298-10306 DOI:10.1021/bi980333x PMID:9665738
- Radhakrishnan, I., Perez-Alvarado, G. C., Dyson, H. J., Wright, P. E. Conformational preferences in the Ser(133)-phosphorylated and non-phosphorylated forms of the kinase inducible transactivation domain of CREB FEBS Letters 1998 430:317-322 DOI:10.1016/s0014-5793(98)00680-2 PMID:9688563
- Scrofani, S. D. B., Wright, P. E., Dyson, H. J. (1)H, (13)C and (15)N NMR backbone assignments of 25.5 kDa metallo-beta-lactamase from Bacteroides fragilis Journal of Biomolecular NMR 1998 12:201-202 DOI:10.1023/a:1008279832041 PMID:9729800
- Dyson, H. J., Wright, P. E. Equilibrium NMR studies of unfolded and partially folded proteins Nature Structural Biology 1998 5:499-503 DOI:10.1038/739 PMID:9665178
- Eliezer, D., Yao, J., Dyson, H. J., Wright, P. E. Structural and dynamic characterization of partially folded states of apomyoglobin and implications for protein folding Nature Structural Biology 1998 5:148-155 PMID:9461081
- Zhu, L. M., Dyson, H. J., Wright, P. E. A NOESY-HSQC simulation program, SPIRIT Journal of Biomolecular NMR 1998 11:17-29 DOI:10.1023/a:1008252526537 PMID:9566311
- Dyson, H. J., Bolinger, L., Feher, V. A., Osterhout, J. J., Yao, J., Wright, P. E. Sequence requirements for stabilization of a peptide reverse turn in water solution: proline is not essential for stability European Journal of Biochemistry 1998 255:462-471 DOI:10.1046/j.1432-1327.1998.2550462.x PMID:9716389
- Yao, J., Dyson, H. J., Wright, P. E. Chemical shift dispersion and secondary structure prediction in unfolded and partly folded proteins FEBS Letters 1997 419:285-289 DOI:10.1016/s0014-5793(97)01474-9 PMID:9428652
- Radhakrishnan, I., PerezAlvarado, G. C., Parker, D., Dyson, H. J., Montminy, M. R., Wright, P. E. Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions Cell 1997 91:741-752 DOI:10.1016/s0092-8674(00)80463-8 PMID:9413984
- Donne, D. G., Viles, J. H., Groth, D., Mehlhorn, I., James, T. L., Cohen, F. E., Prusiner, S. B., Wright, P. E., Dyson, H. J. Structure of the recombinant full-length hamster prion protein PrP(29-231): the N terminus is highly flexible Proceedings of the National Academy of Sciences of the United States of America 1997 94:13452-13457 DOI:10.1073/pnas.94.25.13452 PMID:9391046 PMCID:PMC28326
- Bender, C. J., Casimiro, D. R., Peisach, J., Dyson, H. J. Electron spin echo modulation study of the Type I copper protein rusticyanin and its mutant variant His85Ala: implications for the general analysis of weak (14)N superhyperfine interactions Journal of the Chemical Society-Faraday Transactions 1997 93:3967-3980 DOI:10.1039/a704541g
- Casimiro, D. R., Wright, P. E., Dyson, H. J. PCR-based gene synthesis and protein NMR spectroscopy Structure 1997 5:1407-1412 DOI:10.1016/s0969-2126(97)00291-8 PMID:9384559
- Eliezer, D., Jennings, P. A., Dyson, H. J., Wright, P. E. Populating the equilibrium molten globule state of apomyoglobin under conditions suitable for structural characterization by NMR FEBS Letters 1997 417:92-96 DOI:10.1016/s0014-5793(97)01256-8 PMID:9395082
- Bai, Y. W., Karimi, A., Dyson, H. J., Wright, P. E. Absence of a stable intermediate on the folding pathway of protein A Protein Science 1997 6:1449-1457 DOI:10.1002/pro.5560060709 PMID:9232646 PMCID:PMC2143746
- Reymond, M. T., Huo, S. Q., Duggan, B., Wright, P. E., Dyson, H. J. Contribution of increased length and intact capping sequences to the conformational preference for helix in a 31-residue peptide from the C terminus of myohemerythrin Biochemistry 1997 36:5234-5244 DOI:10.1021/bi970038x PMID:9136885
- Dyson, H. J., Jeng, M. F., Tennant, L. L., Slaby, I., Lindell, M., Cui, D. S., Kuprin, S., Holmgren, A. Effects of buried charged groups on cysteine thiol ionization and reactivity in Escherichia coli thioredoxin: structural and functional characterization of mutants of Asp 26 and Lys 57 Biochemistry 1997 36:2622-2636 DOI:10.1021/bi961801a PMID:9054569
- Reymond, M. T., Merutka, G., Dyson, H. J., Wright, P. E. Folding propensities of peptide fragments of myoglobin Protein Science 1997 6:706-716 DOI:10.1002/pro.5560060320 PMID:9070453 PMCID:PMC2143684
- Ghiara, J. B., Ferguson, D. C., Satterthwait, A. C., Dyson, H. J., Wilson, I. A. Structure-based design of a constrained peptide mimic of the HIV-1 V3 loop neutralization site Journal of Molecular Biology 1997 266:31-39 DOI:10.1006/jmbi.1996.0768 PMID:9054968
- Prytulla, S., Dyson, H. J., Wright, P. E. Gene synthesis, high-level expression and assignment of backbone (15)N and (13)C resonances of soybean leghemoglobin FEBS Letters 1996 399:283-289 DOI:10.1016/s0014-5793(96)01278-1 PMID:8985163
- Botuyan, M. V., ToyPalmer, A., Chung, J., Blake, R. C., Beroza, P., Case, D. A., Dyson, H. J. NMR solution structure of Cu(I) rusticyanin from Thiobacillus ferrooxidans: structural basis for the extreme acid stability and redox potential Journal of Molecular Biology 1996 263:752-767 DOI:10.1006/jmbi.1996.0613 PMID:8947573
- Slaby, I., Cerna, V., Jeng, M. F., Dyson, H. J., Holmgren, A. Replacement of Trp(28) in Escherichia coli thioredoxin by site-directed mutagenesis affects thermodynamic stability but not function Journal of Biological Chemistry 1996 271:3091-3096 PMID:8621706
- Jeng, M. F., Dyson, H. J. Direct measurement of the aspartic acid 26 pK(a) for reduced Escherichia coli thioredoxin by (13)C NMR Biochemistry 1996 35:1-6 DOI:10.1021/bi952404n PMID:8555161
- Dyson, H. J., Wright, P. E. Insights into protein folding from NMR Annual Review of Physical Chemistry 1996 47:369-395 DOI:10.1146/annurev.physchem.47.1.369 PMID:8930101
- Campbell, A. P., Sykes, B. D., Norrby, E., AssaMunt, N., Dyson, H. J. Solution conformation of an immunogenic peptide derived from the principal neutralizing determinant of the HIV-2 envelope glycoprotein gp125 Folding & Design 1996 1:157-165 DOI:10.1016/s1359-0278(96)00024-7 PMID:9079375
- Wishart, D. S., Bigam, C. G., Yao, J., Abildgaard, F., Dyson, H. J., Oldfield, E., Markley, J. L., Sykes, B. D. (1)H, (13)C and (15)N chemical shift referencing in biomolecular NMR Journal of Biomolecular NMR 1995 6:135-140 PMID:8589602
- Jeng, M. F., Holmgren, A., Dyson, H. J. Proton sharing between cysteine thiols in Escherichia coli thioredoxin: implications for the mechanism of protein disulfide reduction Biochemistry 1995 34:10101-10105 DOI:10.1021/bi00032a001 PMID:7640264
- Casimiro, D. R., Toypalmer, A., Blake, R. C., Dyson, H. J. Gene synthesis, high-level expression, and mutagenesis of Thiobacillus ferrooxidans rusticyanin: His 85 is a ligand to the blue copper center Biochemistry 1995 34:6640-6648 DOI:10.1021/bi00020a009 PMID:7639845
- Toypalmer, A., Prytulla, S., Dyson, H. J. Complete (13)C assignments for recombinant Cu(I) rusticyanin prediction of secondary structure from patterns of chemical shifts FEBS Letters 1995 365:35-41 DOI:10.1016/0014-5793(95)00423-7 PMID:7774711
- Krebs, J. F., Siuzdak, G., Dyson, H. J., Stewart, J. D., Benkovic, S. J. Detection of a catalytic antibody species acylated at the active site by electrospray mass spectrometry Biochemistry 1995 34:720-723 DOI:10.1021/bi00003a002 PMID:7827028
- Jeng, M. F., Dyson, H. J. Comparison of the hydrogen exchange behavior of reduced and oxidized Escherichia coli thioredoxin Biochemistry 1995 34:611-619 DOI:10.1021/bi00002a028 PMID:7819256
- Merutka, G., Dyson, H. J., Wright, P. E. 'Random coil' (1)H chemical shifts obtained as a function of temperature and trifluoroethanol concentration for the peptide series GGXGG Journal of Biomolecular NMR 1995 5:14-24 DOI:10.1007/bf00227466 PMID:7881270
- Dyson, H. J., Wright, P. E. Antigenic peptides FASEB Journal 1995 9:37-42 PMID:7821757
- Dyson, H. J. Nuclear magnetic resonance of thioredoxin and glutaredoxin Biothiols, Pt B 1995 252:293-306 PMID:7476364
- Yao, J., Bruschweiler, R., Dyson, H. J., Wright, P. E. Differential side chain hydration in a linear peptide containing a type VI turn Journal of the American Chemical Society 1994 116:12051-12052 DOI:10.1021/ja00105a055
- Hunt, A. H., Toypalmer, A., Assamunt, N., Cavanagh, J., Blake, R. C., Dyson, H. J. Nuclear magnetic resonance (15)N and (1)H resonance assignments and global fold of rusticyanin. Insights into the ligation and acid stability of the blue copper site Journal of Molecular Biology 1994 244:370-384 DOI:10.1006/jmbi.1994.1737 PMID:7990128
- Yao, J., Feher, V. A., Espejo, B. F., Reymond, M. T., Wright, P. E., Dyson, H. J. Stabilization of a type VI turn in a family of linear peptides in water solution Journal of Molecular Biology 1994 243:736-753 DOI:10.1016/0022-2836(94)90044-2 PMID:7966293
- Yao, J., Dyson, H. J., Wright, P. E. Three-dimensional structure of a type VI turn in a linear peptide in water solution. Evidence for stacking of aromatic rings as a major stabilizing factor Journal of Molecular Biology 1994 243:754-766 DOI:10.1016/0022-2836(94)90045-0 PMID:7966294
- Jeng, M. F., Campbell, A. P., Begley, T., Holmgren, A., Case, D. A., Wright, P. E., Dyson, H. J. High-resolution solution structures of oxidized and reduced Escherichia coli thioredoxin Structure 1994 2:853-868 DOI:10.1016/s0969-2126(94)00086-7 PMID:7812718
- Siuzdak, G., Krebs, J. F., Benkovic, S. J., Dyson, H. J. Binding of hapten to a single chain catalytic antibody demonstrated by electrospray mass spectrometry Journal of the American Chemical Society 1994 116:7937-7938 DOI:10.1021/ja00096a077
- Chandrasekhar, K., Campbell, A. P., Jeng, M. F., Holmgren, A., Dyson, H. J. Effect of disulfide bridge formation on the NMR spectrum of a protein: studies on oxidized and reduced Escherichia coli thioredoxin Journal of Biomolecular NMR 1994 4:411-432 PMID:8019144
- Dyson, H. J., Jeng, M. F., Model, P., Holmgren, A. Characterization by (1)H NMR of a C32S,C35S double mutant of Escherichia coli thioredoxin confirms its resemblance to the reduced wild-type protein FEBS Letters 1994 339:11-17 PMID:8313957
- Koide, S., Dyson, H. J., Wright, P. E. Characterization of a folding intermediate of apoplastocyanin trapped by proline isomerization Biochemistry 1993 32:12299-12310 DOI:10.1021/bi00097a005 PMID:8241116
- Waltho, J. P., Feher, V. A., Merutka, G., Dyson, H. J., Wright, P. E. Peptide models of protein folding initiation sites. 1. Secondary structure formation by peptides corresponding to the G- and H-helices of myoglobin Biochemistry 1993 32:6337-6347 DOI:10.1021/bi00076a006 PMID:8518279
- Shin, H. C., Merutka, G., Waltho, J. P., Wright, P. E., Dyson, H. J. Peptide models of protein folding initiation sites. 2. The G-H turn region of myoglobin acts as a helix stop signal Biochemistry 1993 32:6348-6355 DOI:10.1021/bi00076a007 PMID:8518280
- Shin, H. C., Merutka, G., Waltho, J. P., Tennant, L. L., Dyson, H. J., Wright, P. E. Peptide models of protein folding initiation sites. 3. The G-H helical hairpin of myoglobin Biochemistry 1993 32:6356-6364 DOI:10.1021/bi00076a008 PMID:8518281
- Dyson, H. J., Wright, P. E. Peptide conformation and protein folding Current Opinion in Structural Biology 1993 3:60-65 DOI:10.1016/0959-440x(93)90203-w
- Stone, M. J., Chandrasekhar, K., Holmgren, A., Wright, P. E., Dyson, H. J. Comparison of backbone and tryptophan side-chain dynamics of reduced and oxidized Escherichia coli thioredoxin using (15)N NMR relaxation measurements Biochemistry 1993 32:426-435 DOI:10.1021/bi00053a007 PMID:8422352
- Dyson, H. J., Norrby, E., Hoey, K., Parks, D. E., Lerner, R. A., Wright, P. E. Immunogenic peptides corresponding to the dominant antigenic region alanine-597 to cysteine-619 in the transmembrane protein of simian immunodeficiency virus have a propensity to fold in aqueous solution Biochemistry 1992 31:1458-1463 DOI:10.1021/bi00120a024 PMID:1737004
- Dyson, H. J., Merutka, G., Waltho, J. P., Lerner, R. A., Wright, P. E. Folding of peptide fragments comprising the complete sequence of proteins. Models for initiation of protein folding. I. Myohemerythrin Journal of Molecular Biology 1992 226:795-817 DOI:10.1016/0022-2836(92)90633-u PMID:1507227
- Dyson, H. J., Sayre, J. R., Merutka, G., Shin, H. C., Lerner, R. A., Wright, P. E. Folding of peptide fragments comprising the complete sequence of proteins. Models for initiation of protein folding. II. Plastocyanin Journal of Molecular Biology 1992 226:819-835 DOI:10.1016/0022-2836(92)90634-v PMID:1507228
- Chandrasekhar, K., Profy, A. T., Dyson, H. J. Solution conformational preferences of immunogenic peptides derived from the principal neutralizing determinant of the HIV-1 envelope glycoprotein gp120 Biochemistry 1991 30:9187-9194 DOI:10.1021/bi00102a009 PMID:1892828
- Fairbrother, W. J., Cavanagh, J., Dyson, H. J., Palmer, A. G., Sutrina, S. L., Reizer, J., Saier, M. H., Wright, P. E. Polypeptide backbone resonance assignments and secondary structure of Bacillus subtilis enzyme IIIglc determined by two-dimensional and three-dimensional heteronuclear NMR spectroscopy Biochemistry 1991 30:6896-6907 DOI:10.1021/bi00242a013 PMID:1906345
- Chandrasekhar, K., Krause, G., Holmgren, A., Dyson, H. J. Assignment of the (15)N NMR spectra of reduced and oxidized Escherichia coli thioredoxin FEBS Letters 1991 284:178-183 DOI:10.1016/0014-5793(91)80679-w PMID:2060637
- Nachman, R. J., Roberts, V. A., Dyson, H. J., Holman, G. M., Tainer, J. A. Active conformation of an insect neuropeptide family Proceedings of the National Academy of Sciences of the United States of America 1991 88:4518-4522 DOI:10.1073/pnas.88.10.4518 PMID:2034692
- Dyson, H. J., Tennant, L. L., Holmgren, A. Proton-transfer effects in the active-site region of Escherichia coli thioredoxin using two-dimensional (1)H NMR Biochemistry 1991 30:4262-4268 DOI:10.1021/bi00231a023 PMID:1850621
- Oldstone, M. B. A., Tishon, A., Lewicki, H., Dyson, H. J., Feher, V. A., Assamunt, N., Wright, P. E. Mapping the anatomy of the immunodominant domain of the human immunodeficiency virus gp41 transmembrane protein: peptide conformation analysis using monoclonal antibodies and proton nuclear magnetic resonance spectroscopy Journal of Virology 1991 65:1727-1734 PMID:2002540 PMCID:PMC239977
- Dyson, H. J., Wright, P. E. Defining solution conformations of small linear peptides Annual Review of Biophysics and Biophysical Chemistry 1991 20:519-538 DOI:10.1146/annurev.biophys.20.1.519 PMID:1867725
- Dyson, H. J., Satterthwait, A. C., Lerner, R. A., Wright, P. E. Conformational preferences of synthetic peptides derived from the immunodominant site of the circumsporozoite protein of Plasmodium falciparum by (1)H NMR Biochemistry 1990 29:7828-7837 DOI:10.1021/bi00486a008 PMID:2261440
- Wright, P. E., Dyson, H. J., Lerner, R. A., Riechmann, L., Tsang, P. Antigen-antibody interactions: an NMR approach Biochemical Pharmacology 1990 40:83-88 DOI:10.1016/0006-2952(90)90182-k PMID:1695509
- Dyson, H. J., Gippert, G. P., Case, D. A., Holmgren, A., Wright, P. E. Three-dimensional solution structure of the reduced form of Escherichia coli thioredoxin determined by nuclear magnetic resonance spectroscopy Biochemistry 1990 29:4129-4136 DOI:10.1021/bi00469a016 PMID:2193685
- Satterthwait, A. C., Chiang, L. C., Arrhenius, T., Cabezas, E., Zavala, F., Dyson, H. J., Wright, P. E., Lerner, R. A. The conformational restriction of synthetic vaccines for malaria Bulletin of the World Health Organization 1990 68:17-25 PMID:2094582 PMCID:PMC2393045
- Osterhout, J. J., Baldwin, R. L., York, E. J., Stewart, J. M., Dyson, H. J., Wright, P. E. (1)H NMR studies of the solution conformations of an analog of the C-peptide of ribonuclease A Biochemistry 1989 28:7059-7064 DOI:10.1021/bi00443a042 PMID:2819049
- Dyson, H. J., Holmgren, A., Wright, P. E. Assignment of the proton NMR spectrum of reduced and oxidized thioredoxin: sequence-specific assignments, secondary structure, and global fold Biochemistry 1989 28:7074-7087 DOI:10.1021/bi00443a044 PMID:2684270
- Wright, P. E., Dyson, H. J., Lerner, R. A. Conformation of peptide fragments of proteins in aqueous solution: implications for initiation of protein folding Biochemistry 1988 27:7167-7175 DOI:10.1021/bi00419a001 PMID:3061450
- Dyson, H. J., Holmgren, A., Wright, P. E. Structural differences between oxidized and reduced thioredoxin monitored by two-dimensional (1)H NMR spectroscopy FEBS Letters 1988 228:254-258 DOI:10.1016/0014-5793(88)80010-3 PMID:3277863
- Dyson, H. J., Rance, M., Houghten, R. A., Lerner, R. A., Wright, P. E. Folding of immunogenic peptide fragments of proteins in water solution. I. Sequence requirements for the formation of a reverse turn Journal of Molecular Biology 1988 201:161-200 DOI:10.1016/0022-2836(88)90446-9 PMID:2843644
- Dyson, H. J., Rance, M., Houghten, R. A., Wright, P. E., Lerner, R. A. Folding of immunogenic peptide fragments of proteins in water solution. II. The nascent helix Journal of Molecular Biology 1988 201:201-217 DOI:10.1016/0022-2836(88)90447-0 PMID:3418697
- Dyson, H. J., Lerner, R. A., Wright, P. E. The physical basis for induction of protein-reactive antipeptide antibodies Annual Review of Biophysics and Biophysical Chemistry 1988 17:305-324 DOI:10.1146/annurev.biophys.17.1.305 PMID:2456075
- Dyson, H. J., Cross, K. J., Ostresh, J., Houghten, R. A., Wilson, I. A., Wright, P. E., Lerner, R. A. Selection by site-directed antibodies of small regions of peptides which are ordered in water Ciba Foundation Symposia 1986 119:58-75 PMID:3525041
- Dyson, H. J., Cross, K. J., Houghten, R. A., Wilson, I. A., Wright, P. E., Lerner, R. A. The immunodominant site of a synthetic immunogen has a conformational preference in water for a type-II reverse turn Nature 1985 318:480-483 PMID:4069219
- Dyson, H. J., Beattie, J. K. Spin state and unfolding equilibria of ferricytochrome c in acidic solutions Journal of Biological Chemistry 1982 257:2267-2273 PMID:6277891
- Upcroft, P., Dyson, H. J., Wake, R. G. Characteristics of a Bacillus subtilis W23 mutant temperature sensitive for initiation of chromosome replication Journal of Bacteriology 1975 121:121-127 PMID:803947 PMCID:PMC285621
thesis
- Dyson, H. J. How do proteins work? 2008
- Dyson, H. J. Dynamic and equilibrium spectrophotometry of hemoproteins 1977

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