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Chen, Jason Shih-Hao
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Chen, Jason Shih-Hao

Graduate Student
Non-Faculty Academic
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Positions

  • 2017 - Scientific Director, Automated Synthesis Facility, Scripps Research
  • 2016 - 2017 Senior Staff Scientist, Scripps Research
  • 2011 - 2016 Faculty Member, Iowa State University
  • 2008 - 2011 Postdoctoral Research Associate, Scripps Research

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  • Doctoral Dissertation
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Publications

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  • academic article

    • Yan, N. L., Santos-Martins, D., Rennella, E., Sanchez, B. B., Chen, J. S., Kay, L. E., Wilson, I. A., Morgan, G. J., Forli, S., Kelly, J. W. Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins Bioorganic & Medicinal Chemistry Letters  2020 30  DOI:10.1016/j.bmcl.2020.127356  PMID:32631553  PMCID:PMC7402200
    • Matos, J. L. M., Green, S. A., Chun, Y. G., Dang, V. Q., Dushin, R. G., Richardson, P., Chen, J. S., Piotrowski, D. W., Paegel, B. M., Shenvi, R. A. Cycloisomerization of Olefins in Water Angewandte Chemie-International Edition  2020  DOI:10.1002/anie.202003948  PMID:32285542
    • Dik, D. A., Zhang, N., Chen, J. S., Webb, B., Schultz, P. G. Semisynthesis of a Bacterium with Non-canonical Cell-Wall Cross-Links Journal of the American Chemical Society  2020 142:10910-10913  DOI:10.1021/jacs.0c02956  PMID:32510943
    • Qian, S., Li, Z. Q., Li, M., Wisniewski, S. R., Qiao, J. X., Richter, J. M., Ewing, W. R., Eastgate, M. D., Chen, J. S., Yu, J. Q. Ligand-Enabled Pd(II)-Catalyzed C(sp(3))-H Lactonization Using Molecular Oxygen as Oxidant Organic Letters  2020 22:3960-3963  DOI:10.1021/acs.orglett.0c01243  PMID:32330054
    • Zambaldo, C., Vinogradova, E. V., Qi, X., Iaconelli, J., Suciu, R. M., Koh, M., Senkane, K., Chadwick, S. R., Sanchez, B. B., Chen, J. S., Chatterjee, A. K., Liu, P., et al. 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles Journal of the American Chemical Society  2020 142:8972-8979  DOI:10.1021/jacs.0c02721  PMID:32302104
    • Flood, D. T., Zhang, X. J., Fu, X., Zhao, Z. X., Asai, S., Sanchez, B. B., Sturgell, E. J., Vantourout, J. C., Richardson, P., Flanagan, M. E., Piotrowski, D. W., K?lmel, D. K., et al. RASS-Enabled S/P-C and S-N Bond Formation for DEL Synthesis Angewandte Chemie-International Edition  2020 59:7377-7383  DOI:10.1002/anie.201915493  PMID:32050046
    • Gao, D. W., Gao, Y., Shao, H. L., Qiao, T. Z., Wang, X., Sanchez, B. B., Chen, J. S., Liu, P., Engle, K. M. Cascade CuH-catalysed conversion of alkynes into enantioenriched 1,1-disubstituted products Nature Catalysis  2020 3:23-29  DOI:10.1038/s41929-019-0384-6
    • Romine, A. M., Yang, K. S., Karunananda, M. K., Chen, J. S., Engle, K. M. Synthetic and mechanistic studies of a versatile heteroaryl thioether directing group for Pd(II) catalysis ACS Catalysis  2019 9:7626-7640  DOI:10.1021/acscatal.9b01471
    • Feldman, A. W., Dien, V. T., Karadeema, R. J., Fischer, E. C., You, Y., Anderson, B. A., Krishnamurthy, R., Chen, J. S., Li, L., Romesberg, F. E. Optimization of replication, transcription, and translation in a semi-synthetic organism Journal of the American Chemical Society  2019 141:10644-10653  DOI:10.1021/jacs.9b02075  PMID:31241334
    • Flood, D. T., Asai, S., Zhang, X., Wang, J., Yoon, L., Adams, Z. C., Dillingham, B. C., Sanchez, B. B., Vantourout, J. C., Flanagan, M. E., Piotrowsld, D. W., Richardson, P., et al. Expanding reactivity in DNA-encoded library synthesis via reversible binding of DNA to an inert quaternary ammonium support Journal of the American Chemical Society  2019 141:9998-10006  DOI:10.1021/jacs.9b03774  PMID:31136164
    • Ni, S., Munoz Padial, N., Kingston, C., Vantourout, J. C., Schmitt, D. C., Edwards, J. T., Kruszyk, M., Merchant, R. R., Mykhailiuk, P. K., Sanchez, B., Yang, S., Perry, M., et al. A radical approach to anionic chemistry: synthesis of ketones, alcohols, and amines Journal of the American Chemical Society  2019 141:6726-6739  DOI:10.1021/jacs.9b02238  PMID:30943023
    • Nimmagadda, S. K.*, Liu, M.*, Karunananda, M. K., Gao, D. W., Apolinar, O., Chen, J. S., Liu, P., Engle, K. M. Catalytic, enantioselective α-alkylation of azlactones with nonconjugated alkenes by directed nucleopalladation Angewandte Chemie-International Edition  2019 58:3923-3927  DOI:10.1002/anie.201814272  PMID:30729619 (* = equal contribution)
    • Kingston, C., Wallace, M. A., Allentoff, A. J., deGruyter, J. N., Chen, J. S., Gong, S. X., Bonacorsi, S., Baran, P. S. Direct carbon isotope exchange through decarboxylative carboxylation Journal of the American Chemical Society  2019 141:774-779  DOI:10.1021/jacs.8b12035  PMID:30605319
    • Flood, D. T., Hintzen, J. C. J., Bird, M. J., Cistrone, P. A., Chen, J. S., Dawson, P. E. Leveraging the Knorr pyrazole synthesis for the facile generation of thioester surrogates for use in native chemical ligation Angewandte Chemie-International Edition  2018 57:11634-11639  DOI:10.1002/anie.201805191  PMID:29908104  PMCID:PMC6126375
    • Chen, T. G., Barton, L. M., Lin, Y., Tsien, J., Kossler, D., Bastida, I., Asai, S., Bi, C., Chen, J. S., Shan, M., Fang, H., Fang, F. G., et al. Building C(sp3)-rich complexity by combining cycloaddition and C-C cross-coupling reactions Nature  2018 560:350-354  DOI:10.1038/s41586-018-0391-9  PMID:30061620
    • Wang, J., Lundberg, H., Asai, S., Martin-Acosta, P., Chen, J. S., Brown, S., Farrell, W., Dushin, R. G., O'Donnell, C. J., Ratnayake, A. S., Richardson, P., Liu, Z., et al. Kinetically guided radical-based synthesis of C(sp(3))-C(sp(3)) linkages on DNA Proceedings of the National Academy of Sciences of the United States of America  2018 115:E6404-E6410  DOI:10.1073/pnas.1806900115  PMID:29946037  PMCID:PMC6048552
    • Gao, D. W., Xiao, Y., Liu, M., Liu, Z., Karunananda, M. K., Chen, J. S., Engle, K. M. Catalytic, enantioselective synthesis of allenyl boronates ACS Catalysis  2018 8:3650-3654  DOI:10.1021/acscatal.8b00626
    • Derosa, J.*, Tran, V. T.*, Boulous, M. N., Chen, J. S., Engle, K. M. Nickel-catalyzed β,γ-dicarbofunctionalization of alkenyl carbonyl compounds via conjunctive cross-coupling Journal of the American Chemical Society  2017 139:10657-10660  DOI:10.1021/jacs.7b06567  PMID:28738150 (* = equal contribution)
    • Nicolaou, K. C., Wang, Y., Lu, M., Mandal, D., Pattanayak, M. R., Yu, R., Shah, A. A., Chen, J. S., Zhang, H., Crawford, J. J., Pasunoori, L., Poudel, Y. B., et al. Streamlined total synthesis of uncialamycin and its application to the synthesis of designed analogues for biological investigations Journal of the American Chemical Society  2016 138:8235-8246  DOI:10.1021/jacs.6b04339  PMID:27266267
    • Chen, J. S., Abeykoon, G. A. Catalytic enantioselective α,β,γ-trioxygenation Organic Letters  2015 17:6050-6053  DOI:10.1021/acs.orglett.5b03050  PMID:26651079
    • Fought, E. L., Chatterjee, S., Windus, T. L., Chen, J. S. Computational and NMR spectroscopic evidence for stereochemistry-dependent conformations of 2,2,6,6-tetramethylpiperidinyl-masked 1,2-diols Journal of Organic Chemistry  2015 80:9967-9972  DOI:10.1021/acs.joc.5b01516  PMID:26427992
    • Khan, A. H., Chen, J. S. Synthesis of breitfussin B by late-stage bromination Organic Letters  2015 17:3718-3721  DOI:10.1021/acs.orglett.5b01702  PMID:26192988
    • Zenner, M. D., Madbouly, S. A., Chen, J. S., Kessler, M. R. Unexpected tackifiers from isosorbide ChemSusChem  2015 8:448-451  DOI:10.1002/cssc.201402667  PMID:25601572
    • Chen, R. Q., Chen, J. S., Zhang, C. Q., Kessler, M. R. Rapid room-temperature polymerization of bio-based multiaziridine-containing compounds RSC Advances  2015 5:1557-1563  DOI:10.1039/c4ra10335a
    • Abeykoon, G. A., Chatterjee, S., Chen, J. S. anti-Diols from α-oxyaldehydes: synthesis and stereochemical assignment of oxylipins from Dracontium loretense Organic Letters  2014 16:3248-3251  DOI:10.1021/ol501263y  PMID:24918974
    • Zenner, M. D., Xia, Y., Chen, J. S., Kessler, M. R. Polyurethanes from isosorbide-based diisocyanates ChemSusChem  2013 6:1182-1185  DOI:10.1002/cssc.201300126  PMID:23757328
    • Nicolaou, K. C., Valiulin, R. A., Pokorski, J. K., Chang, V., Chen, J. S. Bio-inspired synthesis and biological evaluation of a colchicine-related compound library Bioorganic & Medicinal Chemistry Letters  2012 22:3776-3780  DOI:10.1016/j.bmcl.2012.04.007  PMID:22542017  PMCID:PMC3353021
    • Jiang, X., Shi, L., Liu, H., Khan, A. H., Chen, J. S. Gas extrusion in natural products total synthesis Organic & Biomolecular Chemistry  2012 10:8383-8392  DOI:10.1039/c2ob26152a  PMID:22940671
    • Nicolaou, K. C., Simmons, N. L., Ying, Y. C., Heretsch, P. M., Chen, J. S. Enantioselective dichlorination of allylic alcohols Journal of the American Chemical Society  2011 133:8134-8137  DOI:10.1021/ja202555m  PMID:21542622  PMCID:PMC3107004
    • Nicolaou, K. C., Simmons, N. L., Chen, J. S., Haste, N. M., Nizet, V. Total synthesis and biological evaluation of marinopyrrole A and analogues Tetrahedron Letters  2011 52:2041-2043  DOI:10.1016/j.tetlet.2010.09.059  PMID:21499535  PMCID:PMC3077031
    • Hirschmann, R. F., Nicolaou, K. C., Angeles, A. R., Chen, J. S., Smith, A. B. The beta-d-glucose scaffold as a beta-turn mimetic Accounts of Chemical Research  2009 42:1511-1520  DOI:10.1021/ar900020x  PMID:19624154  PMCID:PMC2764824
    • Nicolaou, K. C.*, Chen, J. S.*, Dalby, S. M. From nature to the laboratory and into the clinic Bioorganic & Medicinal Chemistry  2009 17:2290-2303  DOI:10.1016/j.bmc.2008.10.089  PMID:19028103  PMCID:PMC2665039 (* = equal contribution)
    • Nicolaou, K. C.*, Harrison, S. T.*, Chen, J. S. Discoveries from the abyss: The abyssomicins and their total synthesis Synthesis-Stuttgart  2009 33-42  DOI:10.1055/s-0028-1083259  PMID:20047014  PMCID:PMC2677807 (* = equal contribution)
    • Nicolaou, K. C.*, Chen, J. S.*, Edmonds, D. J., Estrada, A. A. Recent advances in the chemistry and biology of naturally occurring antibiotics Angewandte Chemie-International Edition  2009 48:660-719  DOI:10.1002/anie.200801695  PMID:19130444  PMCID:PMC2730216 (* = equal contribution)
    • Nicolaou, K. C.*, Ellery, S. P.*, Chen, J. S. Samarium diiodide mediated reactions in total synthesis Angewandte Chemie-International Edition  2009 48:7140-7165  DOI:10.1002/anie.200902151  PMID:19714695  PMCID:PMC2771673 (* = equal contribution)
    • Nicolaou, K. C.*, Chen, J. S.* The art of total synthesis through cascade reactions Chemical Society Reviews  2009 38:2993-3009  DOI:10.1039/b903290h  PMID:19847336  PMCID:PMC2766600 (* = equal contribution)
    • degree-related publication Nicolaou, K. C.*, Chen, J. S.* Total synthesis of complex heterocyclic natural products Pure and Applied Chemistry  2008 80:727-742  DOI:10.1351/pac200880040727 (* = equal contribution)
    • degree-related publication Nicolaou, K. C.*, Chen, J. S.*, Zhang, H. J., Montero, A. Asymmetric synthesis and biological properties of uncialamycin and 26-epi-uncialamycin Angewandte Chemie-International Edition  2008 47:185-189  DOI:10.1002/anie.200704577  PMID:18058881 (* = equal contribution)
    • degree-related publication Nicolaou, K. C., Zhang, H., Chen, J. S., Crawford, J. J., Pasunoori, L. Total synthesis and stereochemistry of uncialamycin Angewandte Chemie-International Edition  2007 46:4704-4707  DOI:10.1002/anie.200700917  PMID:17497617
    • Sheehan, S. M., Lalic, G., Chen, J. S., Shair, M. D. A highly efficient and convergent reaction for the synthesis of bridgehead enone-containing polycyclic ring systems Angewandte Chemie - International Edition  2000 39:2714-2715  DOI:10.1002/1521-3773(20000804)39:15<2714::aid-anie2714>3.3.co;2-t  PMID:10934402
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Background

education and training

  • Ph.D. in Chemistry, Scripps Research 2003 - 2008
  • M.A. in Chemistry, Harvard University 2000 - 2001
  • A.B. in Chemistry, Harvard University 1997 - 2000

advisee of

  • graduate advising relationship

    • Nicolaou, K.C., Ph.D.  candidacy, 2004 - 2008
  • postdoc or fellow advising relationship

    • Nicolaou, K.C., Ph.D.  candidacy, 2008 - 2011
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Contact

full name

  • Jason Shih-Hao Chen

geographic location

  • Scripps California 

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