recent publications
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academic article
- Turner, L. D., Nielsen, A. L., Lin, L., Campedelli, A. J., Silvaggi, N. R., Chen, J. S., Wakefield, A. E., Allen, K. N., Janda, K. D. Use of Crystallography and Molecular Modeling for the Inhibition of the Botulinum Neurotoxin A Protease Acs Medicinal Chemistry Letters 2021 12:1318-1324 DOI:10.1021/acsmedchemlett.1c00325 PMID:34413962 PMCID:PMC8365998
- Li, F. Z., Yang, L. C., Zhang, J. Y., Chen, J. S., Renata, H. Stereoselective Synthesis of β-Branched Aromatic α-Amino Acids by Biocatalytic Dynamic Kinetic Resolution* Angewandte Chemie-International Edition 2021 DOI:10.1002/anie.202105656 PMID:34056805 PMCID:PMC8319157
- Dik, D. A., Zhang, N., Sturgell, E. J., Sanchez, B. B., Chen, J. S., Webb, B., Vanderpool, K. G., Schultz, P. G. A synthetic 5,3-cross-link in the cell wall of rod-shaped Gram-positive bacteria Proceedings of the National Academy of Sciences of the United States of America 2021 118 DOI:10.1073/pnas.2100137118 PMID:33836615 PMCID:PMC7980369
- Flood, D. T., Hintzen, J. C. J., Knouse, K. W., Hill, D. E., Lu, C. X., Cistrone, P. A., Chen, J. S., Otomo, T., Dawson, P. Selenomethionine as an expressible handle for bioconjugations Proceedings of the National Academy of Sciences of the United States of America 2021 118 DOI:10.1073/pnas.2005164118 PMID:33602807 PMCID:PMC7923357
- Saint-Denis, T. G., Lam, N. Y. S., Chekshin, N., Richardson, P. F., Chen, J. S., Elleraas, J., Hesp, K. D., Schmitt, D. C., Lian, Y. J., Huh, C. W., Yu, J. Q. Mechanistic Study of Enantioselective Pd-Catalyzed C(sp(3))-H Activation of Thioethers Involving Two Distinct Stereomodels ACS Catalysis 2021 11:9738-9753 DOI:10.1021/acscatal.1c02808
- Flood, D. T., Knouse, K. W., Vantourout, J. C., Kitamura, S., Sanchez, B. B., Sturgell, E. J., Chen, J. S., Wolan, D. W., Baran, P. S., Dawson, P. E. Synthetic Elaboration of Native DNA by RASS (SENDR) ACS Central Science 2020 6:1789-1799 DOI:10.1021/acscentsci.0c00680 PMID:33145415 PMCID:PMC7596865
- Fan, Z. L., Zhao, S., Liu, T., Shen, P. X., Cui, Z. N., Zhuang, Z., Shao, Q., Chen, J. S., Ratnayake, A. S., Flanagan, M. E., Kolmel, D. K., Piotrowski, D. W., et al. Merging C(sp(3))-H activation with DNA-encoding Chemical Science 2020 11:12282-12288 DOI:10.1039/d0sc03935g PMID:34094436 PMCID:PMC8162953
- Yan, N. L., Santos-Martins, D., Rennella, E., Sanchez, B. B., Chen, J. S., Kay, L. E., Wilson, I. A., Morgan, G. J., Forli, S., Kelly, J. W. Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins Bioorganic & Medicinal Chemistry Letters 2020 30 DOI:10.1016/j.bmcl.2020.127356 PMID:32631553 PMCID:PMC7402200
- Matos, J. L. M., Green, S. A., Chun, Y. G., Dang, V. Q., Dushin, R. G., Richardson, P., Chen, J. S., Piotrowski, D. W., Paegel, B. M., Shenvi, R. A. Cycloisomerization of Olefins in Water Angewandte Chemie-International Edition 2020 DOI:10.1002/anie.202003948 PMID:32285542
- Dik, D. A., Zhang, N., Chen, J. S., Webb, B., Schultz, P. G. Semisynthesis of a Bacterium with Non-canonical Cell-Wall Cross-Links Journal of the American Chemical Society 2020 142:10910-10913 DOI:10.1021/jacs.0c02956 PMID:32510943
- Qian, S., Li, Z. Q., Li, M., Wisniewski, S. R., Qiao, J. X., Richter, J. M., Ewing, W. R., Eastgate, M. D., Chen, J. S., Yu, J. Q. Ligand-Enabled Pd(II)-Catalyzed C(sp(3))-H Lactonization Using Molecular Oxygen as Oxidant Organic Letters 2020 22:3960-3963 DOI:10.1021/acs.orglett.0c01243 PMID:32330054
- Zambaldo, C., Vinogradova, E. V., Qi, X., Iaconelli, J., Suciu, R. M., Koh, M., Senkane, K., Chadwick, S. R., Sanchez, B. B., Chen, J. S., Chatterjee, A. K., Liu, P., et al. 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles Journal of the American Chemical Society 2020 142:8972-8979 DOI:10.1021/jacs.0c02721 PMID:32302104
- Flood, D. T., Zhang, X. J., Fu, X., Zhao, Z. X., Asai, S., Sanchez, B. B., Sturgell, E. J., Vantourout, J. C., Richardson, P., Flanagan, M. E., Piotrowski, D. W., K?lmel, D. K., et al. RASS-Enabled S/P-C and S-N Bond Formation for DEL Synthesis Angewandte Chemie-International Edition 2020 59:7377-7383 DOI:10.1002/anie.201915493 PMID:32050046
- Gao, D. W., Gao, Y., Shao, H. L., Qiao, T. Z., Wang, X., Sanchez, B. B., Chen, J. S., Liu, P., Engle, K. M. Cascade CuH-catalysed conversion of alkynes into enantioenriched 1,1-disubstituted products Nature Catalysis 2020 3:23-29 DOI:10.1038/s41929-019-0384-6
- Romine, A. M., Yang, K. S., Karunananda, M. K., Chen, J. S., Engle, K. M. Synthetic and mechanistic studies of a versatile heteroaryl thioether directing group for Pd(II) catalysis ACS Catalysis 2019 9:7626-7640 DOI:10.1021/acscatal.9b01471
- Feldman, A. W., Dien, V. T., Karadeema, R. J., Fischer, E. C., You, Y., Anderson, B. A., Krishnamurthy, R., Chen, J. S., Li, L., Romesberg, F. E. Optimization of replication, transcription, and translation in a semi-synthetic organism Journal of the American Chemical Society 2019 141:10644-10653 DOI:10.1021/jacs.9b02075 PMID:31241334
- Flood, D. T., Asai, S., Zhang, X., Wang, J., Yoon, L., Adams, Z. C., Dillingham, B. C., Sanchez, B. B., Vantourout, J. C., Flanagan, M. E., Piotrowsld, D. W., Richardson, P., et al. Expanding reactivity in DNA-encoded library synthesis via reversible binding of DNA to an inert quaternary ammonium support Journal of the American Chemical Society 2019 141:9998-10006 DOI:10.1021/jacs.9b03774 PMID:31136164
- Ni, S., Munoz Padial, N., Kingston, C., Vantourout, J. C., Schmitt, D. C., Edwards, J. T., Kruszyk, M., Merchant, R. R., Mykhailiuk, P. K., Sanchez, B., Yang, S., Perry, M., et al. A radical approach to anionic chemistry: synthesis of ketones, alcohols, and amines Journal of the American Chemical Society 2019 141:6726-6739 DOI:10.1021/jacs.9b02238 PMID:30943023
- Nimmagadda, S. K.*, Liu, M.*, Karunananda, M. K., Gao, D. W., Apolinar, O., Chen, J. S., Liu, P., Engle, K. M. Catalytic, enantioselective α-alkylation of azlactones with nonconjugated alkenes by directed nucleopalladation Angewandte Chemie-International Edition 2019 58:3923-3927 DOI:10.1002/anie.201814272 PMID:30729619 (* = equal contribution)
- Kingston, C., Wallace, M. A., Allentoff, A. J., deGruyter, J. N., Chen, J. S., Gong, S. X., Bonacorsi, S., Baran, P. S. Direct carbon isotope exchange through decarboxylative carboxylation Journal of the American Chemical Society 2019 141:774-779 DOI:10.1021/jacs.8b12035 PMID:30605319
- Flood, D. T., Hintzen, J. C. J., Bird, M. J., Cistrone, P. A., Chen, J. S., Dawson, P. E. Leveraging the Knorr pyrazole synthesis for the facile generation of thioester surrogates for use in native chemical ligation Angewandte Chemie-International Edition 2018 57:11634-11639 DOI:10.1002/anie.201805191 PMID:29908104 PMCID:PMC6126375
- Chen, T. G., Barton, L. M., Lin, Y., Tsien, J., Kossler, D., Bastida, I., Asai, S., Bi, C., Chen, J. S., Shan, M., Fang, H., Fang, F. G., et al. Building C(sp3)-rich complexity by combining cycloaddition and C-C cross-coupling reactions Nature 2018 560:350-354 DOI:10.1038/s41586-018-0391-9 PMID:30061620
- Wang, J., Lundberg, H., Asai, S., Martin-Acosta, P., Chen, J. S., Brown, S., Farrell, W., Dushin, R. G., O'Donnell, C. J., Ratnayake, A. S., Richardson, P., Liu, Z., et al. Kinetically guided radical-based synthesis of C(sp(3))-C(sp(3)) linkages on DNA Proceedings of the National Academy of Sciences of the United States of America 2018 115:E6404-E6410 DOI:10.1073/pnas.1806900115 PMID:29946037 PMCID:PMC6048552
- Gao, D. W., Xiao, Y., Liu, M., Liu, Z., Karunananda, M. K., Chen, J. S., Engle, K. M. Catalytic, enantioselective synthesis of allenyl boronates ACS Catalysis 2018 8:3650-3654 DOI:10.1021/acscatal.8b00626
- Derosa, J.*, Tran, V. T.*, Boulous, M. N., Chen, J. S., Engle, K. M. Nickel-catalyzed β,γ-dicarbofunctionalization of alkenyl carbonyl compounds via conjunctive cross-coupling Journal of the American Chemical Society 2017 139:10657-10660 DOI:10.1021/jacs.7b06567 PMID:28738150 (* = equal contribution)
- Nicolaou, K. C., Wang, Y., Lu, M., Mandal, D., Pattanayak, M. R., Yu, R., Shah, A. A., Chen, J. S., Zhang, H., Crawford, J. J., Pasunoori, L., Poudel, Y. B., et al. Streamlined total synthesis of uncialamycin and its application to the synthesis of designed analogues for biological investigations Journal of the American Chemical Society 2016 138:8235-8246 DOI:10.1021/jacs.6b04339 PMID:27266267
- Chen, J. S., Abeykoon, G. A. Catalytic enantioselective α,β,γ-trioxygenation Organic Letters 2015 17:6050-6053 DOI:10.1021/acs.orglett.5b03050 PMID:26651079
- Fought, E. L., Chatterjee, S., Windus, T. L., Chen, J. S. Computational and NMR spectroscopic evidence for stereochemistry-dependent conformations of 2,2,6,6-tetramethylpiperidinyl-masked 1,2-diols Journal of Organic Chemistry 2015 80:9967-9972 DOI:10.1021/acs.joc.5b01516 PMID:26427992
- Khan, A. H., Chen, J. S. Synthesis of breitfussin B by late-stage bromination Organic Letters 2015 17:3718-3721 DOI:10.1021/acs.orglett.5b01702 PMID:26192988
- Zenner, M. D., Madbouly, S. A., Chen, J. S., Kessler, M. R. Unexpected tackifiers from isosorbide ChemSusChem 2015 8:448-451 DOI:10.1002/cssc.201402667 PMID:25601572
- Chen, R. Q., Chen, J. S., Zhang, C. Q., Kessler, M. R. Rapid room-temperature polymerization of bio-based multiaziridine-containing compounds RSC Advances 2015 5:1557-1563 DOI:10.1039/c4ra10335a
- Abeykoon, G. A., Chatterjee, S., Chen, J. S. anti-Diols from α-oxyaldehydes: synthesis and stereochemical assignment of oxylipins from Dracontium loretense Organic Letters 2014 16:3248-3251 DOI:10.1021/ol501263y PMID:24918974
- Zenner, M. D., Xia, Y., Chen, J. S., Kessler, M. R. Polyurethanes from isosorbide-based diisocyanates ChemSusChem 2013 6:1182-1185 DOI:10.1002/cssc.201300126 PMID:23757328
- Nicolaou, K. C., Valiulin, R. A., Pokorski, J. K., Chang, V., Chen, J. S. Bio-inspired synthesis and biological evaluation of a colchicine-related compound library Bioorganic & Medicinal Chemistry Letters 2012 22:3776-3780 DOI:10.1016/j.bmcl.2012.04.007 PMID:22542017 PMCID:PMC3353021
- Jiang, X., Shi, L., Liu, H., Khan, A. H., Chen, J. S. Gas extrusion in natural products total synthesis Organic & Biomolecular Chemistry 2012 10:8383-8392 DOI:10.1039/c2ob26152a PMID:22940671
- Nicolaou, K. C., Simmons, N. L., Ying, Y. C., Heretsch, P. M., Chen, J. S. Enantioselective dichlorination of allylic alcohols Journal of the American Chemical Society 2011 133:8134-8137 DOI:10.1021/ja202555m PMID:21542622 PMCID:PMC3107004
- Nicolaou, K. C., Simmons, N. L., Chen, J. S., Haste, N. M., Nizet, V. Total synthesis and biological evaluation of marinopyrrole A and analogues Tetrahedron Letters 2011 52:2041-2043 DOI:10.1016/j.tetlet.2010.09.059 PMID:21499535 PMCID:PMC3077031
- Hirschmann, R. F., Nicolaou, K. C., Angeles, A. R., Chen, J. S., Smith, A. B. The beta-d-glucose scaffold as a beta-turn mimetic Accounts of Chemical Research 2009 42:1511-1520 DOI:10.1021/ar900020x PMID:19624154 PMCID:PMC2764824
- Nicolaou, K. C.*, Chen, J. S.*, Dalby, S. M. From nature to the laboratory and into the clinic Bioorganic & Medicinal Chemistry 2009 17:2290-2303 DOI:10.1016/j.bmc.2008.10.089 PMID:19028103 PMCID:PMC2665039 (* = equal contribution)
- Nicolaou, K. C.*, Harrison, S. T.*, Chen, J. S. Discoveries from the abyss: The abyssomicins and their total synthesis Synthesis-Stuttgart 2009 33-42 DOI:10.1055/s-0028-1083259 PMID:20047014 PMCID:PMC2677807 (* = equal contribution)
- Nicolaou, K. C.*, Chen, J. S.*, Edmonds, D. J., Estrada, A. A. Recent advances in the chemistry and biology of naturally occurring antibiotics Angewandte Chemie-International Edition 2009 48:660-719 DOI:10.1002/anie.200801695 PMID:19130444 PMCID:PMC2730216 (* = equal contribution)
- Nicolaou, K. C.*, Ellery, S. P.*, Chen, J. S. Samarium diiodide mediated reactions in total synthesis Angewandte Chemie-International Edition 2009 48:7140-7165 DOI:10.1002/anie.200902151 PMID:19714695 PMCID:PMC2771673 (* = equal contribution)
- Nicolaou, K. C.*, Chen, J. S.* The art of total synthesis through cascade reactions Chemical Society Reviews 2009 38:2993-3009 DOI:10.1039/b903290h PMID:19847336 PMCID:PMC2766600 (* = equal contribution)
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Nicolaou, K. C.*, Chen, J. S.*
Total synthesis of complex heterocyclic natural products
Pure and Applied Chemistry
2008
80:727-742
DOI:10.1351/pac200880040727
(* = equal contribution)
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Nicolaou, K. C.*, Chen, J. S.*, Zhang, H. J., Montero, A.
Asymmetric synthesis and biological properties of uncialamycin and 26-epi-uncialamycin
Angewandte Chemie-International Edition
2008
47:185-189
DOI:10.1002/anie.200704577
PMID:18058881
(* = equal contribution)
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Nicolaou, K. C., Zhang, H., Chen, J. S., Crawford, J. J., Pasunoori, L.
Total synthesis and stereochemistry of uncialamycin
Angewandte Chemie-International Edition
2007
46:4704-4707
DOI:10.1002/anie.200700917
PMID:17497617
- Sheehan, S. M., Lalic, G., Chen, J. S., Shair, M. D. A highly efficient and convergent reaction for the synthesis of bridgehead enone-containing polycyclic ring systems Angewandte Chemie - International Edition 2000 39:2714-2715 DOI:10.1002/1521-3773(20000804)39:15<2714::aid-anie2714>3.3.co;2-t PMID:10934402