recent publications
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academic article
- Oravcova, M., Gadaleta, M. C., Nie, M. H., Reubens, M. C., Limbo, O., Russell, P., Boddy, M. N. Brc1 promotes the focal accumulation and SUMO ligase activity of Smc5-Smc6 during replication stress Molecular and Cellular Biology 2019 39:00271-18 DOI:10.1128/mcb.00271-18 PMID:30348841 PMCID:PMC6321882
- Oravcova, M., Boddy, M. N. Recruitment, loading, and activation of the Smc5-Smc6 SUMO ligase Current Genetics 2019 65:669-676 DOI:10.1007/s00294-018-0922-9 PMID:30600397 PMCID:PMC6511331
- Nie, M., Moser, B. A., Nakamura, T. M., Boddy, M. N. SUMO-targeted ubiquitin ligase activity can either suppress or promote genome instability, depending on the nature of the DNA lesion PLoS Genetics 2017 13 DOI:10.1371/journal.pgen.1006776 PMID:28475613 PMCID:PMC5438191
- Nie, M., Arner, E., Prudden, J., Schaffer, L., Head, S., Boddy, M. N. Functional crosstalk between the PP2A and SUMO pathways revealed by analysis of STUbL suppressor, razor 1-1 PLoS Genetics 2016 12 DOI:10.1371/journal.pgen.1006165 PMID:27398807 PMCID:PMC4939958
- Nie, M., Vashisht, A. A., Wohlschlegel, J. A., Boddy, M. N. High confidence fission yeast SUMO conjugates identified by tandem denaturing affinity purification Scientific Reports 2015 5:14389 DOI:10.1038/srep14389 PMID:26404184 PMCID:PMC4585906
- Nie, M., Boddy, M. N. Pli1(PIAS1) SUMO ligase protected by the nuclear pore-associated SUMO protease Ulp1(SENP1/2) Journal of Biological Chemistry 2015 290:22678-22685 DOI:10.1074/jbc.M115.673038 PMID:26221037 PMCID:PMC4566240
- Zilio, N., Codlin, S., Vashisht, A. A., Bitton, D. A., Head, S. R., Wohlschlegel, J. A., Bahler, J., Boddy, M. N. A novel histone deacetylase complex in the control of transcription and genome stability Molecular and Cellular Biology 2014 34:3500-3514 DOI:10.1128/mcb.00519-14 PMID:25002536 PMCID:PMC4135615
- Groocock, L. M., Nie, M., Prudden, J., Moiani, D., Wang, T., Cheltsov, A., Rambo, R. P., Arvai, A. S., Hitomi, C., Tainer, J. A., Luger, K., Perry, J. J. P., et al. RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response EMBO Reports 2014 15:601-608 DOI:10.1002/embr.201338369 PMID:24714598 PMCID:PMC4210088
- Zilio, N., Wehrkamp-Richter, S., Boddy, M. N. A new versatile system for rapid control of gene expression in the fission yeast Schizosaccharomyces pombe Yeast 2012 29:425-434 DOI:10.1002/yea.2920 PMID:22968950 PMCID:PMC3478897
- Nie, M. H., Aslanian, A., Prudden, J., Heideker, J., Vashisht, A. A., Wohlschlegel, J. A., Yates, J. R., Boddy, M. N. Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions Journal of Biological Chemistry 2012 287:29610-29619 DOI:10.1074/jbc.M112.379768 PMID:22730331 PMCID:PMC3436128
- Wehrkamp-Richter, S., Hyppa, R. W., Prudden, J., Smith, G. R., Boddy, M. N. Meiotic DNA joint molecule resolution depends on Nse5-Nse6 of the Smc5-Smc6 holocomplex Nucleic Acids Research 2012 40:9633-9646 DOI:10.1093/nar/gks713 PMID:22855558 PMCID:PMC3479181
- Groocock, L. M., Prudden, J., Perry, J. J. P., Boddy, M. N. The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast Molecular and Cellular Biology 2012 32:276-287 DOI:10.1128/mcb.06184-11 PMID:22064477 PMCID:PMC3255783
- Prudden, J., Perry, J. J. P., Nie, M. H., Vashisht, A. A., Arvai, A. S., Hitomi, C., Guenther, G., Wohlschlegel, J. A., Tainer, J. A., Boddy, M. N. DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes Molecular and Cellular Biology 2011 31:2299-2310 DOI:10.1128/mcb.05188-11 PMID:21444718 PMCID:PMC3133251
- Heideker, J., Prudden, J., Perry, J. J. P., Tainer, J. A., Boddy, M. N. SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability PLoS Genetics 2011 7:e1001320 DOI:10.1371/journal.pgen.1001320 PMID:21408210 PMCID:PMC3048374
- Bekes, M., Prudden, J., Srikumar, T., Raught, B., Boddy, M. N., Salvesen, G. S. The dynamics and mechanism of SUMO chain deconjugation by SUMO-specific proteases Journal of Biological Chemistry 2011 286:10238-10247 DOI:10.1074/jbc.M110.205153 PMID:21247896 PMCID:PMC3060478
- Heideker, J., Perry, J. J. P., Boddy, M. N. Genome stability roles of sumo-targeted ubiquitin ligases DNA Repair 2009 8:517-524 DOI:10.1016/j.dnarep.2009.01.010 PMID:19233742 PMCID:PMC2685196
- Prudden, J., Perry, J. J. P., Arvai, A. S., Tainer, J. A., Boddy, M. N. Molecular mimicry of SUMO promotes DNA repair Nature Structural & Molecular Biology 2009 16:509-516 DOI:10.1038/nsmb.1582 PMID:19363481 PMCID:PMC2711901
- Perry, J. J. P., Tainer, J. A., Boddy, M. N. A sim-ultaneous role for SUMO and ubiquitin Trends in Biochemical Sciences 2008 33:201-208 DOI:10.1016/j.tibs.2008.02.001 PMID:18403209
- Pebernard, S., Schaffer, L., Campbell, D., Head, S. R., Boddy, M. N. Localization of Smc5/6 to centromeres and telomeres requires heterochromatin and SUMO, respectively EMBO Journal 2008 27:3011-3023 DOI:10.1038/emboj.2008.220 PMID:18923417 PMCID:PMC2585169
- Pebernard, S., Perry, J. J. P., Tainer, J. A., Boddy, M. N. Nse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability Molecular Biology of the Cell 2008 19:4099-4109 DOI:10.1091/mbc.E08-02-0226 PMID:18667531 PMCID:PMC2555936
- Prudden, J., Pebernard, S., Raffa, G., Slavin, D. A., Perry, J. J. P., Tainer, J. A., McGowan, C. H., Boddy, M. N. Sumo-targeted ubiquitin ligases in genome stability EMBO Journal 2007 26:4089-4101 DOI:10.1038/sj.emboj.7601838 PMID:17762865 PMCID:PMC2230673
- Raffa, G. D., Wohlschlegel, J., Yates, J. R., Boddy, M. N. SUMO-binding motifs mediate the Rad60-dependent response to replicative stress and self-association Journal of Biological Chemistry 2006 281:27973-27981 DOI:10.1074/jbc.M601943200 PMID:16880212
- Pebernard, S., Wohschlegel, J., McDonald, W. H., Yates, J. R., Boddy, M. N. The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex Molecular and Cellular Biology 2006 26:1617-1630 DOI:10.1128/mcb.26.5.1617-1630.2006 PMID:16478984 PMCID:PMC1430260
- Kai, M., Boddy, M. N., Russell, P., Wang, T. S. F. Replication checkpoint kinase Cds1 regulates Mus81 to reserve genome integrity during replication stress Genes & Development 2005 19:919-932 DOI:10.1101/gad.1304305 PMID:15805465 PMCID:PMC1080131
- Pebernard, S., McDonald, W. H., Pavlova, Y., Yates, J. R., Boddy, M. N. Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis Molecular Biology of the Cell 2004 15:4866-4876 DOI:10.1091/mbc.E04-05-0436 PMID:15331764 PMCID:PMC524734
- Blais, V., Gao, H., Elwell, C. A., Boddy, M. N., Gaillard, P. H. L., Russell, P., McGowan, C. H. RNA interference inhibition of Mus81 reduces mitotic recombination in human cells Molecular Biology of the Cell 2004 15:552-562 DOI:10.1091/mbc.E03-08-0580 PMID:14617801 PMCID:PMC329235
- Smith, G. R., Boddy, M. N., Shanahan, P., Russell, P. Fission yeast Mus81.Eme1 Holliday junction resolvase is required for meiotic crossing over but not for gene conversion Genetics 2003 165:2289-2293 PMID:14704204 PMCID:PMC1462924
- McDonald, W. H., Pavlova, Y., Yates, J. R., Boddy, M. N. Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex Journal of Biological Chemistry 2003 278:45460-45467 DOI:10.1074/jbc.M308828200 PMID:12966087
- Boddy, M. N., Shanahan, P., McDonald, W. H., Lopez-Girona, A., Noguchi, E., Yates, J. R., Russell, P. Replication checkpoint kinase Cds1 regulates recombinational repair protein Rad60 Molecular and Cellular Biology 2003 23:5939-5946 DOI:10.1128/mcb.23.16.5939-5946.2003 PMID:12897162 PMCID:PMC166335
- Boddy, M. N., Russell, P. DNA replication checkpoint Current Biology 2001 11:R953-R956 DOI:10.1016/s0960-9822(01)00572-3 PMID:11728320
- Chen, X. B., Melchionna, R., Denis, C. M., Gaillard, P. H. L., Blasina, A., Van de Weyer, I., Boddy, M. N., Russell, P., Vialard, J., McGowan, C. H. Human Mus81-associated endonuclease cleaves Holliday junctions in vitro Molecular Cell 2001 8:1117-1127 DOI:10.1016/s1097-2765(01)00375-6 PMID:11741546
- Boddy, M. N., Gaillard, P. H. L., McDonald, W. H., Shanahan, P., Yates, J. R., Russell, P. Mus81-Eme1 are essential components of a Holliday junction resolvase Cell 2001 107:537-548 DOI:10.1016/s0092-8674(01)00536-0 PMID:11719193
- Tanaka, K., Boddy, M. N., Chen, X. B., McGowan, C. H., Russell, P. Threonine-11, phosphorylated by Rad3 and atm in vitro, is required for activation of fission yeast checkpoint kinase Cds1 Molecular and Cellular Biology 2001 21:3398-3404 DOI:10.1128/mcb.21.10.3398-3404.2001 PMID:11313465
- Rhind, N., Baber-Furnari, B. A., Lopez-Girona, A., Boddy, M. N., Brondello, J. M., Moser, B., Shanahan, P., Blasina, A., McGowan, C., Russell, P. DNA damage checkpoint control of mitosis in fission yeast Cold Spring Harbor Symposia on Quantitative Biology 2000 65:353-359 DOI:10.1101/sqb.2000.65.353 PMID:12760050
- Boddy, M. N., Lopez-Girona, A., Shanahan, P., Interthal, H., Heyer, W. D., Russell, P. Damage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1 Molecular and Cellular Biology 2000 20:8758-8766 DOI:10.1128/mcb.20.23.8758-8766.2000 PMID:11073977
- Baber-Furnari, B. A., Rhind, N., Boddy, M. N., Shanahan, P., Lopez-Girona, A., Russell, P. Regulation of mitotic inhibitor Mik1 helps to enforce the DNA damage checkpoint Molecular Biology of the Cell 2000 11:1-11 DOI:10.1091/mbc.11.1.1 PMID:10637286 PMCID:PMC14752
- Brondello, J. M., Boddy, M. N., Furnari, B., Russell, P. Basis for the checkpoint signal specificity that regulates Chk1 and Cds1 protein kinases Molecular and Cellular Biology 1999 19:4262-4269 PMID:10330167 PMCID:PMC104386
- Furnari, B., Blasina, A., Boddy, M. N., McGowan, C. H., Russell, P. Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1 Molecular Biology of the Cell 1999 10:833-845 DOI:10.1091/mbc.10.4.833 PMID:10198041 PMCID:PMC25205
- Boddy, M. N., Russell, P. DNA replication checkpoint control Frontiers in Bioscience 1999 4:D841-D848 PMID:10577839
- Duprez, E., Saurin, A. J., Desterro, J. M., Lallemand-Breitenbach, V., Howe, K., Boddy, M. N., Solomon, E., de The, H., Hay, R. T., Freemont, P. S. SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation Journal of Cell Science 1999 112:381-393 PMID:9885291
- Boddy, M. N., Furnari, B., Mondesert, O., Russell, P. Replication checkpoint enforced by kinases Cds1 and Chk1 Science 1998 280:909-912 DOI:10.1126/science.280.5365.909 PMID:9572736
- Howe, K., Williamson, J., Boddy, N., Sheer, D., Freemont, P., Solomon, E. The ubiquitin-homology gene PIC1: Characterization of mouse (Pic1) and human (UBL1) genes and pseudogenes Genomics 1998 47:92-100 DOI:10.1006/geno.1997.5091 PMID:9465300
- Boddy, M. N., Duprez, E., Borden, K. L. B., Freemont, P. S. Surface residue mutations of the PML RING finger domain alter the formation of nuclear matrix-associated PML bodies Journal of Cell Science 1997 110:2197-2205 PMID:9378769
- Saurin, A. J., Borden, K. L. B., Boddy, M. N., Freemont, P. S. Does this have a familiar ring? Trends in Biochemical Sciences 1996 21:208-214 DOI:10.1016/s0968-0004(96)80017-x PMID:8744354
- Boddy, M. N., Howe, K., Etkin, L. D., Solomon, E., Freemont, P. S. PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia Oncogene 1996 13:971-982 PMID:8806687
- Otto, W. R., Nanchahal, J., Lu, Q. L., Boddy, N., Dover, R. Survival of allogeneic cells in cultured organotypic skin grafts Plastic and Reconstructive Surgery 1995 96:166-176 DOI:10.1097/00006534-199507000-00025 PMID:7604097
- Borden, K. L. B., Boddy, M. N., Lally, J., Oreilly, N. J., Martin, S., Howe, K., Solomon, E., Freemont, P. S. The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML EMBO Journal 1995 14:1532-1541 PMID:7729428 PMCID:PMC398240
- Boddy, M. N., Freemont, P. S., Borden, K. L. B. The p53-associated protein MDM2 contains a newly characterized zinc-binding domain called the RING finger Trends in Biochemical Sciences 1994 19:198-199 DOI:10.1016/0968-0004(94)90020-5 PMID:8048160