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Blankman, Jacqueline
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Blankman, Jacqueline

Graduate Student
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Positions

  • 2017 - Associate Director, Pharmacology, Abide Therapeutics
  • 2012 - 2016 Senior Scientist, Abide Therapeutics
  • 2012 - 2013 Postdoctoral Associate, Scripps Research

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Publications

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  • academic article

    • Clapper, J. R., Henry, C. L., Niphakis, M. J., Knize, A. M., Coppola, A. R., Simon, G. M., Ngo, N., Herbst, R. A., Herbst, D. M., Reed, A. W., Cisar, J. S., Weber, O. D., et al. Monoacylglycerol lipase inhibition in human and rodent systems supports clinical evaluation of endocannabinoid modulators Journal of Pharmacology and Experimental Therapeutics  2018 367:494-508  DOI:10.1124/jpet.118.252296  PMID:30305428
    • Cisar, J. S., Weber, O. D., Clapper, J. R., Blankman, J. L., Henry, C. L., Simon, G. M., Alexander, J. P., Jones, T. K., Ezekowitz, R. A. B., O'Neill, G. P., Grice, C. A. Identification of ABX-1431, a selective inhibitor of monoacylglycerol lipase and clinical candidate for treatment of neurological disorders Journal of Medicinal Chemistry  2018 61:9062-9084  DOI:10.1021/acs.jmedchem.8b00951  PMID:30067909
    • Viader, A., Blankman, J. L., Zhong, P., Liu, X., Schlosburg, J. E., Joslyn, C. M., Liu, Q. S., Tomarchio, A. J., Lichtman, A. H., Selley, D. E., Sim-Selley, L. J., Cravatt, B. Metabolic interplay between astrocytes and neurons regulates endocannabinoid action Cell Reports  2015 12:798-808  DOI:10.1016/j.celrep.2015.06.075  PMID:26212325  PMCID:PMC4526356
    • degree-related publication Naydenov, A. V., Horne, E. A., Cheah, C. S., Swinney, K., Hsu, K. L., Cao, J. K., Marrs, W. R., Blankman, J. L., Tu, S., Cherry, A. E., Fung, S., Wen, A., et al. ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice Neuron  2014 83:361-371  DOI:10.1016/j.neuron.2014.06.030  PMID:25033180  PMCID:PMC4136499
    • degree-related publication Chen, D. H., Naydenov, A., Blankman, J. L., Mefford, H. C., Davis, M., Sul, Y., Barloon, A. S., Bonkowski, E., Wolff, J., Matsushita, M., Smith, C., Cravatt, B. F., et al. Two novel mutations in ABHD12: expansion of the mutation spectrum in PHARC and assessment of their functional effects Human Mutation  2013 34:1672-1678  DOI:10.1002/humu.22437  PMID:24027063  PMCID:PMC3855015
    • degree-related publication Thomas, G., Betters, J. L., Lord, C. C., Brown, A. L., Marshall, S., Ferguson, D., Sawyer, J., Davis, M. A., Melchior, J. T., Blume, L. C., Howlett, A. C., Ivanova, P. T., et al. The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome Cell Reports  2013 5:508-520  DOI:10.1016/j.celrep.2013.08.047  PMID:24095738  PMCID:PMC3833083
    • degree-related publication Blankman, J. L., Cravatt, B. F. Chemical probes of endocannabinoid metabolism Pharmacological Reviews  2013 65:849-871  DOI:10.1124/pr.112.006387  PMID:23512546  PMCID:PMC3639726
    • degree-related publication Blankman, J. L., Long, J. Z., Trauger, S. A., Siuzdak, G., Cravatt, B. F. ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC Proceedings of the National Academy of Sciences of the United States of America  2013 110:1500-1505  DOI:10.1073/pnas.1217121110  PMID:23297193  PMCID:PMC3557017
    • degree-related publication Blankman, J. L., Cravatt, B. F. The endocannabinoid system: from basic research to translational opportunity ACS Chemical Neuroscience  2012 3:337-338  DOI:10.1021/cn3000444  PMCID:PMC3382449
    • degree-related publication Booker, L., Kinsey, S. G., Abdullah, R. A., Blankman, J. L., Long, J. Z., Ezzili, C., Boger, D. L., Cravatt, B. F., Lichtman, A. H. The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice British Journal of Pharmacology  2012 165:2485-2496  DOI:10.1111/j.1476-5381.2011.01445.x  PMID:21506952  PMCID:PMC3423256
    • degree-related publication Nomura, D. K., Morrison, B. E., Blankman, J. L., Long, J. Z., Kinsey, S. G., Marcondes, M. C. G., Ward, A. M., Hahn, Y. K., Lichtman, A. H., Conti, B., Cravatt, B. F. Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation Science  2011 334:809-813  DOI:10.1126/science.1209200  PMID:22021672  PMCID:PMC3249428
    • degree-related publication Straiker, A., Wager-Miller, J., Hu, S. S., Blankman, J. L., Cravatt, B. F., Mackie, K. Cox-2 and fatty acid amide hydrolase can regulate the time course of depolarization-induced suppression of excitation British Journal of Pharmacology  2011 164:1672-1683  DOI:10.1111/j.1476-5381.2011.01486.x  PMID:21564090  PMCID:PMC3230814
    • degree-related publication Zhong, P., Pan, B., Gao, X. P., Blankman, J. L., Cravatt, B. F., Liu, Q. S. Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum Journal of Physiology-London  2011 589:4847-4855  DOI:10.1113/jphysiol.2011.215509  PMID:21911610  PMCID:PMC3224879
    • degree-related publication Pan, B., Wang, W., Zhong, P., Blankman, J. L., Cravatt, B. F., Liu, Q. S. Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice Journal of Neuroscience  2011 31:13420-13430  DOI:10.1523/jneurosci.2075-11.2011  PMID:21940435  PMCID:PMC3371386
    • degree-related publication Ahn, K., Smith, S. E., Liimatta, M. B., Beidler, D., Sadagopan, N., Dudley, D. T., Young, T., Wren, P., Zhang, Y. H., Swaney, S., Van Becelaere, K., Blankman, J. L., et al. Mechanistic and pharmacological characterization of PF-04457845: A highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain Journal of Pharmacology and Experimental Therapeutics  2011 338:114-124  DOI:10.1124/jpet.111.180257  PMID:21505060  PMCID:PMC3126636
    • degree-related publication Bachovchin, D. A., Ji, T. Y., Li, W. W., Simon, G. M., Blankman, J. L., Adibekian, A., Hoover, H., Niessen, S., Cravatt, B. F. Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening Proceedings of the National Academy of Sciences of the United States of America  2010 107:20941-20946  DOI:10.1073/pnas.1011663107  PMID:21084632  PMCID:PMC3000285
    • degree-related publication Lichtman, A. H., Blankman, J. L., Cravatt, B. F. Endocannabinoid overload Molecular Pharmacology  2010 78:993-995  DOI:10.1124/mol.110.069427  PMID:20952498  PMCID:PMC2993463
    • degree-related publication Godlewski, G., Alapafuja, S. O., Batkai, S., Nikas, S. P., Cinar, R., Offertaler, L., Osei-Hyiaman, D., Liu, J., Mukhopadhyay, B., Harvey-White, J., Tam, J., Pacak, K., et al. Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects Chemistry & Biology  2010 17:1256-1266  DOI:10.1016/j.chembiol.2010.08.013  PMID:21095576  PMCID:PMC3003779
    • degree-related publication Schlosburg, J. E., Blankman, J. L., Long, J. Z., Nomura, D. K., Pan, B., Kinsey, S. G., Nguyen, P. T., Ramesh, D., Booker, L., Burston, J. J., Thomas, E. A., Selley, D. E., et al. Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system Nature Neuroscience  2010 13:1113-1119  DOI:10.1038/nn.2616  PMID:20729846  PMCID:PMC2928870
    • degree-related publication Marrs, W. R., Blankman, J. L., Horne, E. A., Thomazeau, A., Lin, Y. H., Coy, J., Bodor, A. L., Muccioli, G. G., Hu, S. S. J., Woodruff, G., Fung, S., Lafourcade, M., et al. The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors Nature Neuroscience  2010 13:951-957  DOI:10.1038/nn.2601  PMID:20657592  PMCID:PMC2970523
    • degree-related publication Hoover, H. S., Blankman, J. L., Niessen, S., Cravatt, B. F. Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling Bioorganic & Medicinal Chemistry Letters  2008 18:5838-5841  DOI:10.1016/j.bmcl.2008.06.091  PMID:18657971  PMCID:PMC2634297
    • degree-related publication Nomura, D. K., Blankman, J. L., Simon, G. M., Fujioka, K., Issa, R. S., Ward, A. M., Cravatt, B. F., Casida, J. E. Activation of the endocannabinoid system by organophosphorus nerve agents Nature Chemical Biology  2008 4:373-378  DOI:10.1038/nchembio.86  PMID:18438404  PMCID:PMC2597283
    • degree-related publication Blankman, J. L., Simon, G. M., Cravatt, B. F. A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol Chemistry & Biology  2007 14:1347-1356  DOI:10.1016/j.chembiol.2007.11.006  PMID:18096503  PMCID:PMC2692834
    • degree-related publication Li, W. W., Blankman, J. L., Cravatt, B. F. A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases Journal of the American Chemical Society  2007 129:9594-9595  DOI:10.1021/ja073650c  PMID:17629278
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Background

education and training

  • Ph.D. in Chemistry, Scripps Research 2006 - 2012
  • B.A. in Chemistry, Northwestern University 2003 - 2006

advisee of

  • graduate advising relationship

    • Cravatt, Benjamin, Ph.D.  candidacy, 2007 - 2012
  • postdoc or fellow advising relationship

    • Cravatt, Benjamin, Ph.D.  candidacy, 2012 - 2013
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Contact

full name

  • Jacqueline Lorayne Blankman

geographic location

  • Scripps California 

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