recent publications
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academic article
- Cisar, J. S., Weber, O. D., Clapper, J. R., Blankman, J. L., Henry, C. L., Simon, G. M., Alexander, J. P., Jones, T. K., Ezekowitz, R. A. B., O'Neill, G. P., Grice, C. A. Identification of ABX-1431, a selective inhibitor of monoacylglycerol lipase and clinical candidate for treatment of neurological disorders Journal of Medicinal Chemistry 2018 61:9062-9084 DOI:10.1021/acs.jmedchem.8b00951 PMID:30067909
- Clapper, J. R., Henry, C. L., Niphakis, M. J., Knize, A. M., Coppola, A. R., Simon, G. M., Ngo, N., Herbst, R. A., Herbst, D. M., Reed, A. W., Cisar, J. S., Weber, O. D., et al. Monoacylglycerol lipase inhibition in human and rodent systems supports clinical evaluation of endocannabinoid modulators Journal of Pharmacology and Experimental Therapeutics 2018 367:494-508 DOI:10.1124/jpet.118.252296 PMID:30305428
- Viader, A., Blankman, J. L., Zhong, P., Liu, X., Schlosburg, J. E., Joslyn, C. M., Liu, Q. S., Tomarchio, A. J., Lichtman, A. H., Selley, D. E., Sim-Selley, L. J., Cravatt, B. Metabolic interplay between astrocytes and neurons regulates endocannabinoid action Cell Reports 2015 12:798-808 DOI:10.1016/j.celrep.2015.06.075 PMID:26212325 PMCID:PMC4526356
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Naydenov, A. V., Horne, E. A., Cheah, C. S., Swinney, K., Hsu, K. L., Cao, J. K., Marrs, W. R., Blankman, J. L., Tu, S., Cherry, A. E., Fung, S., Wen, A., et al.
ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice
Neuron
2014
83:361-371
DOI:10.1016/j.neuron.2014.06.030
PMID:25033180
PMCID:PMC4136499
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Blankman, J. L., Long, J. Z., Trauger, S. A., Siuzdak, G., Cravatt, B. F.
ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC
Proceedings of the National Academy of Sciences of the United States of America
2013
110:1500-1505
DOI:10.1073/pnas.1217121110
PMID:23297193
PMCID:PMC3557017
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Blankman, J. L., Cravatt, B. F.
Chemical probes of endocannabinoid metabolism
Pharmacological Reviews
2013
65:849-871
DOI:10.1124/pr.112.006387
PMID:23512546
PMCID:PMC3639726
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Thomas, G., Betters, J. L., Lord, C. C., Brown, A. L., Marshall, S., Ferguson, D., Sawyer, J., Davis, M. A., Melchior, J. T., Blume, L. C., Howlett, A. C., Ivanova, P. T., et al.
The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome
Cell Reports
2013
5:508-520
DOI:10.1016/j.celrep.2013.08.047
PMID:24095738
PMCID:PMC3833083
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Chen, D. H., Naydenov, A., Blankman, J. L., Mefford, H. C., Davis, M., Sul, Y., Barloon, A. S., Bonkowski, E., Wolff, J., Matsushita, M., Smith, C., Cravatt, B. F., et al.
Two novel mutations in ABHD12: expansion of the mutation spectrum in PHARC and assessment of their functional effects
Human Mutation
2013
34:1672-1678
DOI:10.1002/humu.22437
PMID:24027063
PMCID:PMC3855015
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Blankman, J. L., Cravatt, B. F.
The endocannabinoid system: from basic research to translational opportunity
ACS Chemical Neuroscience
2012
3:337-338
DOI:10.1021/cn3000444
PMCID:PMC3382449
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Booker, L., Kinsey, S. G., Abdullah, R. A., Blankman, J. L., Long, J. Z., Ezzili, C., Boger, D. L., Cravatt, B. F., Lichtman, A. H.
The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice
British Journal of Pharmacology
2012
165:2485-2496
DOI:10.1111/j.1476-5381.2011.01445.x
PMID:21506952
PMCID:PMC3423256
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Pan, B., Wang, W., Zhong, P., Blankman, J. L., Cravatt, B. F., Liu, Q. S.
Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice
Journal of Neuroscience
2011
31:13420-13430
DOI:10.1523/jneurosci.2075-11.2011
PMID:21940435
PMCID:PMC3371386
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Straiker, A., Wager-Miller, J., Hu, S. S., Blankman, J. L., Cravatt, B. F., Mackie, K.
Cox-2 and fatty acid amide hydrolase can regulate the time course of depolarization-induced suppression of excitation
British Journal of Pharmacology
2011
164:1672-1683
DOI:10.1111/j.1476-5381.2011.01486.x
PMID:21564090
PMCID:PMC3230814
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Nomura, D. K., Morrison, B. E., Blankman, J. L., Long, J. Z., Kinsey, S. G., Marcondes, M. C. G., Ward, A. M., Hahn, Y. K., Lichtman, A. H., Conti, B., Cravatt, B. F.
Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation
Science
2011
334:809-813
DOI:10.1126/science.1209200
PMID:22021672
PMCID:PMC3249428
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Zhong, P., Pan, B., Gao, X. P., Blankman, J. L., Cravatt, B. F., Liu, Q. S.
Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum
Journal of Physiology-London
2011
589:4847-4855
DOI:10.1113/jphysiol.2011.215509
PMID:21911610
PMCID:PMC3224879
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Ahn, K., Smith, S. E., Liimatta, M. B., Beidler, D., Sadagopan, N., Dudley, D. T., Young, T., Wren, P., Zhang, Y. H., Swaney, S., Van Becelaere, K., Blankman, J. L., et al.
Mechanistic and pharmacological characterization of PF-04457845: A highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain
Journal of Pharmacology and Experimental Therapeutics
2011
338:114-124
DOI:10.1124/jpet.111.180257
PMID:21505060
PMCID:PMC3126636
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Lichtman, A. H., Blankman, J. L., Cravatt, B. F.
Endocannabinoid overload
Molecular Pharmacology
2010
78:993-995
DOI:10.1124/mol.110.069427
PMID:20952498
PMCID:PMC2993463
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Schlosburg, J. E., Blankman, J. L., Long, J. Z., Nomura, D. K., Pan, B., Kinsey, S. G., Nguyen, P. T., Ramesh, D., Booker, L., Burston, J. J., Thomas, E. A., Selley, D. E., et al.
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
Nature Neuroscience
2010
13:1113-1119
DOI:10.1038/nn.2616
PMID:20729846
PMCID:PMC2928870
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Godlewski, G., Alapafuja, S. O., Batkai, S., Nikas, S. P., Cinar, R., Offertaler, L., Osei-Hyiaman, D., Liu, J., Mukhopadhyay, B., Harvey-White, J., Tam, J., Pacak, K., et al.
Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects
Chemistry & Biology
2010
17:1256-1266
DOI:10.1016/j.chembiol.2010.08.013
PMID:21095576
PMCID:PMC3003779
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Bachovchin, D. A., Ji, T. Y., Li, W. W., Simon, G. M., Blankman, J. L., Adibekian, A., Hoover, H., Niessen, S., Cravatt, B. F.
Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening
Proceedings of the National Academy of Sciences of the United States of America
2010
107:20941-20946
DOI:10.1073/pnas.1011663107
PMID:21084632
PMCID:PMC3000285
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Marrs, W. R., Blankman, J. L., Horne, E. A., Thomazeau, A., Lin, Y. H., Coy, J., Bodor, A. L., Muccioli, G. G., Hu, S. S. J., Woodruff, G., Fung, S., Lafourcade, M., et al.
The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors
Nature Neuroscience
2010
13:951-957
DOI:10.1038/nn.2601
PMID:20657592
PMCID:PMC2970523
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Nomura, D. K., Blankman, J. L., Simon, G. M., Fujioka, K., Issa, R. S., Ward, A. M., Cravatt, B. F., Casida, J. E.
Activation of the endocannabinoid system by organophosphorus nerve agents
Nature Chemical Biology
2008
4:373-378
DOI:10.1038/nchembio.86
PMID:18438404
PMCID:PMC2597283
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Hoover, H. S., Blankman, J. L., Niessen, S., Cravatt, B. F.
Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling
Bioorganic & Medicinal Chemistry Letters
2008
18:5838-5841
DOI:10.1016/j.bmcl.2008.06.091
PMID:18657971
PMCID:PMC2634297
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Blankman, J. L., Simon, G. M., Cravatt, B. F.
A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol
Chemistry & Biology
2007
14:1347-1356
DOI:10.1016/j.chembiol.2007.11.006
PMID:18096503
PMCID:PMC2692834
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Li, W. W., Blankman, J. L., Cravatt, B. F.
A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases
Journal of the American Chemical Society
2007
129:9594-9595
DOI:10.1021/ja073650c
PMID:17629278