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Baran, Phil
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Baran, Phil

Professor
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Positions

  • 2008 - Professor, Chemistry , Scripps Research
  • 2008 - Member, The Skaggs Institute for Chemical Biology , Scripps Research
  • 2003 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2006 - 2008 Associate Professor (with tenure), Chemistry , Scripps Research
  • 2003 - 2006 Assistant Professor, Chemistry , Scripps Research
  • 2001 - 2003 NIH Postdoctoral Fellow with Dr. E. J. Corey, Harvard University
Dr. Phil Baran explores new avenues for the efficient and practical construction of organic molecules, both naturally occurring and man-made, by pursuing longstanding synthetic challenges and by designing methods of broad utility.

Research Areas research areas

  • Alzheimer (UMLS)
  • Arthritis (UMLS)
  • Cancer (UMLS)

Contact

  • pbaran@scripps.edu

Websites

  • Phil Baran, Ph.D.
  • Laboratory Website
  • Doctoral Dissertation
  • Wikipedia
  • Twitter @BaranLabReads
  • Publications
  • Research
  • Teaching
  • Background
  • Contact
  • Identity
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Publications

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    • Kanda, Y., Nakamura, H., Umemiya, S., Puthukanoori, R. K., Appala, V. R. M., Gaddamanugu, G. K., Paraselli, B. R., Baran, P. S. Two-Phase Synthesis of Taxol Journal of the American Chemical Society  2020 142:10526-10533  DOI:10.1021/jacs.0c03592  PMID:32406238
    • McClymont, K. S., Wang, F. Y., Minakar, A., Baran, P. S. Total Synthesis of (-)-Maximiscin Journal of the American Chemical Society  2020 142:8608-8613  DOI:10.1021/jacs.0c03202  PMID:32338003
    • Flood, D. T., Zhang, X. J., Fu, X., Zhao, Z. X., Asai, S., Sanchez, B. B., Sturgell, E. J., Vantourout, J. C., Richardson, P., Flanagan, M. E., Piotrowski, D. W., K?lmel, D. K., et al. RASS-Enabled S/P-C and S-N Bond Formation for DEL Synthesis Angewandte Chemie-International Edition  2020 59:7377-7383  DOI:10.1002/anie.201915493  PMID:32050046
    • Kawamata, Y., Baran, P. S. Electrosynthesis: Sustainability Is Not Enough Joule  2020 4:701-704  DOI:10.1016/j.joule.2020.02.002
    • Xu, D., Rivas-Bascon, N., Padial, N. M., Knouse, K. W., Zheng, B., Vantourout, J. C., Schmidt, M. A., Eastgate, M. D., Baran, P. S. Enantiodivergent Formation of C-P Bonds: Synthesis of P-Chiral Phosphines and Methylphosphonate Oligonucleotides Journal of the American Chemical Society  2020 142:5785-5792  DOI:10.1021/jacs.9b13898  PMID:32109356
    • Flood, D. T., Kingston, C., Vantourout, J. C., Dawson, P. E., Baran, P. S. DNA encoded libraries: a visitor's guide Israel Journal of Chemistry  2020  DOI:10.1002/ijch.201900133
    • Minteer, S. D., Baran, P. Electrifying Synthesis: Recent Advances in the Methods, Materials, and Techniques for Organic Electrosynthesis Accounts of Chemical Research  2020 53:545-546  DOI:10.1021/acs.accounts.0c00049  PMID:32178522
    • Reisberg, S. H., Gao, Y., Walker, A. S., Helfrich, E. J. N., Clardy, J., Baran, P. S. Total synthesis reveals atypical atropisomerism in a small-molecule natural product, tryptorubin A Science  2020 367:458-463  DOI:10.1126/science.aay9981  PMID:31896661  PMCID:PMC6996792
    • Sheng, T., Zhang, H. J., Shang, M., He, C., Vantourout, J. C., Baran, P. S. Electrochemical Decarboxylative N-Alkylation of Heterocycles Organic Letters  2020 22:7594-7598  DOI:10.1021/acs.orglett.0c02799  PMID:32941044
    • Vantourout, J. C., Adusumalli, S. R., Knouse, K. W., Flood, D. T., Ramirez, A., Padial, N. M., Istrate, A., Maziarz, K., DeGruyter, J. N., Merchant, R. R., Qiao, J. X., Schmidt, M. A., et al. Serine-Selective Bioconjugation Journal of the American Chemical Society  2020 142:17236-17242  DOI:10.1021/jacs.0c05595  PMID:32965106
    • Flood, D. T., Knouse, K. W., Vantourout, J. C., Kitamura, S., Sanchez, B. B., Sturgell, E. J., Chen, J. S., Wolan, D. W., Baran, P. S., Dawson, P. E. Synthetic Elaboration of Native DNA by RASS (SENDR) ACS Central Science  2020 6:1789-1799  DOI:10.1021/acscentsci.0c00680  PMID:33145415  PMCID:PMC7596865
    • He, C., Chu, H., Stratton, T. P., Kossler, D., Eberle, K. J., Flood, D. T., Baran, P. S. Total Synthesis of Tagetitoxin Journal of the American Chemical Society  2020 142:13683-13688  DOI:10.1021/jacs.0c06641  PMID:32687336
    • Kanda, Y., Ishihara, Y., Wilde, N. C., Baran, P. S. Two-Phase Total Synthesis of Taxanes: Tactics and Strategies Journal of Organic Chemistry  2020 85:10293-10320  DOI:10.1021/acs.joc.0c01287  PMID:32663002
    • Kingston, C., Palkowitz, M. D., Takahira, Y., Vantourout, J. C., Peters, B. K., Kawamata, Y., Baran, P. S. A survival guide for the "Electro-curious" Accounts of Chemical Research  2020 53:72-83  DOI:10.1021/acs.accounts.9b00539  PMID:31823612  PMCID:PMC6996934
    • Xiang, J., Shang, M., Kawamata, Y., Lundberg, H., Reisberg, S. H., Chen, M., Mykhailiuk, P., Beutner, G., Collins, M. R., Davies, A., Del Bel, M., Gallego, G. M., et al. Hindered dialkyl ether synthesis with electrogenerated carbocations Nature  2019 573:398-402  DOI:10.1038/s41586-019-1539-y  PMID:31501569
    • Barton, L. M., Edwards, J. T., Johnson, E. C., Bukowski, E. J., Sausa, R. C., Byrd, E. F. C., Orlicki, J. A., Sabatini, J. J., Baran, P. S. Impact of stereo- and regiochemistry on energetic materials Journal of the American Chemical Society  2019 141:12531-12535  DOI:10.1021/jacs.9b06961  PMID:31361955
    • Flood, D. T., Asai, S., Zhang, X., Wang, J., Yoon, L., Adams, Z. C., Dillingham, B. C., Sanchez, B. B., Vantourout, J. C., Flanagan, M. E., Piotrowsld, D. W., Richardson, P., et al. Expanding reactivity in DNA-encoded library synthesis via reversible binding of DNA to an inert quaternary ammonium support Journal of the American Chemical Society  2019 141:9998-10006  DOI:10.1021/jacs.9b03774  PMID:31136164
    • Kawamata, Y., Baran, P. S. Cluster preface: electrochemical synthesis and catalysis Synlett  2019 30:1147-1148  DOI:10.1055/s-0039-1689970
    • Takahira, Y., Chen, M., Kawamata, Y., Mykhailiuk, P., Nakamura, H., Peters, B. K., Reisberg, S. H., Li, C., Chen, L., Hoshikawa, T., Shibuguchi, T., Baran, P. S. Electrochemical C(sp(3))-H fluorination Synlett  2019 30:1178-1182  DOI:10.1055/s-0037-1611737
    • Shang, M., Feu, K. S., Vantourout, J. C., Barton, L. M., Osswald, H. L., Kato, N., Gagaring, K., McNamara, C. W., Chen, G., Hu, L., Ni, S., Fernandez-Canelas, P., et al. Modular, stereocontrolled Cβ-H/Cα-C activation of alkyl carboxylic acids Proceedings of the National Academy of Sciences of the United States of America  2019 116:8721-8727  DOI:10.1073/pnas.1903048116  PMID:30996125  PMCID:PMC6500144
    • Ni, S., Munoz Padial, N., Kingston, C., Vantourout, J. C., Schmitt, D. C., Edwards, J. T., Kruszyk, M., Merchant, R. R., Mykhailiuk, P. K., Sanchez, B., Yang, S., Perry, M., et al. A radical approach to anionic chemistry: synthesis of ketones, alcohols, and amines Journal of the American Chemical Society  2019 141:6726-6739  DOI:10.1021/jacs.9b02238  PMID:30943023
    • Kawamata, Y., Vantourout, J. C., Hickey, D. P., Bai, P., Chen, L., Hou, Q., Qiao, W., Barman, K., Edwards, M. A., Garrido-Castro, A. F., DeGruyter, J. N., Nakamura, H., et al. Electrochemically driven, Ni-catalyzed aryl amination: scope, mechanism, and applications Journal of the American Chemical Society  2019 141:6392-6402  DOI:10.1021/jacs.9b01886  PMID:30905151
    • Smith, J. M., Dixon, J. A., deGruyter, J. N., Baran, P. S. Alkyl sulfinates: radical precursors enabling drug discovery Journal of Medicinal Chemistry  2019 62:2256-2264  DOI:10.1021/acs.jmedchem.8b01303  PMID:30272973
    • Peters, B. K., Rodriguez, K. X., Reisberg, S. H., Beil, S. B., Hickey, D. P., Kawamata, Y., Collins, M., Starr, J., Chen, L., Udyavara, S., Klunder, K., Gorey, T. J., et al. Scalable and safe synthetic organic electroreduction inspired by Li-ion battery chemistry Science  2019 363:838-845  DOI:10.1126/science.aav5606  PMID:30792297
    • Chen, T. G., Zhang, H., Mykhailiuk, P. K., Merchant, R. R., Smith, C. A., Qin, T., Baran, P. S. Quaternary centers by nickel-catalyzed cross-coupling of tertiary carboxylic acids and (hetero)aryl zinc reagents Angewandte Chemie-International Edition  2019 58:2454-2458  DOI:10.1002/anie.201814524  PMID:30623547  PMCID:PMC6391118
    • Nakamura, H., Yasui, K., Kanda, Y., Baran, P. S. 11-step total synthesis of teleocidins B-1-6-4 Journal of the American Chemical Society  2019 141:1494-1497  DOI:10.1021/jacs.8b13697  PMID:30636411  PMCID:PMC6353666
    • Kingston, C., Wallace, M. A., Allentoff, A. J., deGruyter, J. N., Chen, J. S., Gong, S. X., Bonacorsi, S., Baran, P. S. Direct carbon isotope exchange through decarboxylative carboxylation Journal of the American Chemical Society  2019 141:774-779  DOI:10.1021/jacs.8b12035  PMID:30605319
    • He, C., Stratton, T. P., Baran, P. S. Concise total synthesis of herqulines B and C Journal of the American Chemical Society  2019 141:29-32  DOI:10.1021/jacs.8b13029  PMID:30575396
    • Mediouni, S., Chinthalapudi, K., Ekka, M. K., Usui, I., Jablonski, J. A., Clementz, M. A., Mousseau, G., Nowak, J., Macherla, V. R., Beverage, J. N., Esquenazi, E., Baran, P., et al. Didehydro-cortistatin A inhibits HIV-1 by specifically binding to the unstructured basic region of Tat MBio  2019 10:e02662-18  DOI:10.1128/mBio.02662-18  PMID:30723126  PMCID:PMC6368365
    • Ni, S. Y., Garrido-Castro, A. F., Merchant, R. R., de Gruyter, J. N., Schmitt, D. C., Mousseau, J. J., Gallego, G. M., Yang, S., Collins, M. R., Qiao, J. X., Yeung, K. S., Langley, D. R., et al. A general amino acid synthesis enabled by innate radical cross-coupling Angewandte Chemie-International Edition  2018 57:14560-14565  DOI:10.1002/anie.201809310  PMID:30212610
    • Wang, J., Shang, M., Lundberg, H., Feu, K. S., Hecker, S. J., Qin, T., Blackmond, D. G., Baran, P. S. Cu-catalyzed decarboxylative borylation ACS Catalysis  2018 8:9537-9542  DOI:10.1021/acscatal.8b02928
    • Knouse, K. W.*, deGruyter, J. N.*, Schmidt, M. A., Zheng, B., Vantourout, J. C., Kingston, C., Mercer, S. E., McDonald, I. M., Olson, R. E., Zhu, Y., Hang, C., Zhu, J., et al. Unlocking P(V): Reagents for chiral phosphorothioate synthesis Science  2018 361:1234-1238  DOI:10.1126/science.aau3369  PMID:30072577 (* = equal contribution)
    • Chu, H., Dunstl, G., Felding, J., Baran, P. S. Divergent synthesis of thapsigargin analogs Bioorganic & Medicinal Chemistry Letters  2018 28:2705-2707  DOI:10.1016/j.bmcl.2018.03.065  PMID:29636219  PMCID:PMC6119632
    • Chen, T. G., Barton, L. M., Lin, Y., Tsien, J., Kossler, D., Bastida, I., Asai, S., Bi, C., Chen, J. S., Shan, M., Fang, H., Fang, F. G., et al. Building C(sp3)-rich complexity by combining cycloaddition and C-C cross-coupling reactions Nature  2018 560:350-354  DOI:10.1038/s41586-018-0391-9  PMID:30061620
    • Smith, J. M., Harwood, S. J., Baran, P. S. Radical retrosynthesis Accounts of Chemical Research  2018 51:1807-1817  DOI:10.1021/acs.accounts.8b00209  PMID:30070821
    • Wang, J., Lundberg, H., Asai, S., Martin-Acosta, P., Chen, J. S., Brown, S., Farrell, W., Dushin, R. G., O'Donnell, C. J., Ratnayake, A. S., Richardson, P., Liu, Z., et al. Kinetically guided radical-based synthesis of C(sp(3))-C(sp(3)) linkages on DNA Proceedings of the National Academy of Sciences of the United States of America  2018 115:E6404-E6410  DOI:10.1073/pnas.1806900115  PMID:29946037  PMCID:PMC6048552
    • Merchant, R. R., Oberg, K. M., Lin, Y., Novak, A. J. E., Felding, J., Baran, P. S. Divergent synthesis of pyrone diterpenes via radical cross coupling Journal of the American Chemical Society  2018 140:7462-7465  DOI:10.1021/jacs.8b04891  PMID:29921130  PMCID:PMC6016063
    • Baran, P. S. Natural product total synthesis: as exciting as ever and here to stay Journal of the American Chemical Society  2018 140:4751-4755  DOI:10.1021/jacs.8b02266  PMID:29635919
    • Yan, M., Kawamata, Y., Baran, P. S. Synthetic organic electrochemistry: calling all engineers Angewandte Chemie-International Edition  2018 57:4149-4155  DOI:10.1002/anie.201707584  PMID:28834012  PMCID:PMC5823775
    • Merchant, R. R.*, Edwards, J. T.*, Qin, T., Kruszyk, M. M., Bi, C., Che, G., Bao, D. H., Qiao, W., Sun, L., Collins, M. R., Fadeyi, O. O., Gallego, G. M., et al. Modular radical cross-coupling with sulfones enables access to sp(3)-rich (fluoro)alkylated scaffolds Science  2018 360:75-80  DOI:10.1126/science.aar7335  PMID:29456201 (* = equal contribution)
    • Peters, D. S., Romesberg, F. E., Baran, P. S. Scalable access to arylomycins via C-H functionalization logic Journal of the American Chemical Society  2018 140:2072-2075  DOI:10.1021/jacs.8b00087  PMID:29381350  PMCID:PMC5817625
    • Parker, C. G., Kuttruff, C. A., Galmozzi, A., Jørgensen, L., Yeh, C.-H., Hermanson, D. J., Wang, Y., Artola, M., McKerrall, S. J., Josyln, C. M., Nørremark, B., Dünstl, G., et al. Chemical proteomics identifies SLC25A20 as a functional target of the ingenol class of actinic keratosis drugs ACS Central Science  2017 3:1276-1285  DOI:10.1021/acscentsci.7b00420  PMID:29296668  PMCID:PMC5746860
    • Degruyter, J. N., Malins, L. R., Wimmer, L., Clay, K. J., Lopez-Ogalla, J., Qin, T., Cornella, J., Liu, Z., Che, G., Bao, D., Stevens, J. M., Ojao, J. X., et al. CITU: a peptide and decarboxylative coupling reagent Organic Letters  2017 19:6196-6199  DOI:10.1021/acs.orglett.7b03121  PMID:29115835  PMCID:PMC5792187
    • Yan, M., Kawamata, Y., Baran, P. S. Synthetic organic electrochemical methods since 2000: on the verge of a renaissance Chemical Reviews  2017 117:13230-13319  DOI:10.1021/acs.chemrev.7b00397  PMID:28991454
    • Li, C., Kawamata, Y., Nakamura, H., Vantourout, J. C., Liu, Z., Hou, Q., Bao, D., Starr, J. T., Chen, J., Yan, M., Baran, P. S. Electrochemically enabled, nickel-catalyzed amination Angewandte Chemie-International Edition  2017 56:13088-13093  DOI:10.1002/anie.201707906  PMID:28834098
    • Mathur, A., Wang, B., Smith, D., Li, J., Pawluczyk, J., Sun, J. H., Wong, M. K., Krishnananthan, S., Wu, D. R., Sun, D., Li, P., Yip, S., et al. Development of the large-scale synthesis of tetrahydropyran glycine, a precursor to the HCV NS5A inhibitor BMS-986097 Journal of Organic Chemistry  2017 82:10376-10387  DOI:10.1021/acs.joc.7b01852  PMID:28877441
    • Smith, J. M., Qin, T., Merchant, R. R., Edwards, J. T., Malins, L. R., Liu, Z., Che, G., Shen, Z., Shaw, S. A., Eastgate, M. D., Baran, P. S. Decarboxylative alkynylation Angewandte Chemie-International Edition  2017 56:11906-11910  DOI:10.1002/anie.201705107  PMID:28636185  PMCID:PMC5792189
    • Trammell, R., See, Y. Y., Herrmann, A. T., Xie, N., Diaz, D. E., Siegler, M. A., Baran, P. S., Garcia-Bosch, I. Decoding the Mechanism of Intramolecular Cu-Directed Hydroxylation of sp3 C-H Bonds Journal of Organic Chemistry  2017 82:7887-7904  DOI:10.1021/acs.joc.7b01069  PMID:28654755
    • Yan, M., Baran, P. S. BMS-663068: Another quiet victory for chemistry Organic Process Research & Development  2017 21:1091-1094  DOI:10.1021/acs.oprd.7b00208
    • deGruyter, J. N., Malins, L. R., Baran, P. S. Residue-Specific Peptide Modification: A Chemist's Guide Biochemistry  2017 56:3863-3873  DOI:10.1021/acs.biochem.7b00536  PMID:28653834
    • Li, C., Wang, J., Barton, L. M., Yu, S., Tian, M., Peters, D. S., Kumar, M., Yu, A. W., Johnson, K. A., Chatterjee, A. K., Yan, M., Baran, P. S. Decarboxylative borylation Science  2017 356  DOI:10.1126/science.aam7355  PMID:28408721
    • Kawamata, Y., Yan, M., Liu, Z., Bao, D. H., Chen, J., Starr, J. T., Baran, P. S. Scalable, electrochemical oxidation of unactivated C-H bonds Journal of the American Chemical Society  2017 139:7448-7451  DOI:10.1021/jacs.7b03539  PMID:28510449  PMCID:PMC5465511
    • Edwards, J. T., Merchant, R. R., McClymont, K. S., Knouse, K. W., Qin, T., Malins, L. R., Vokits, B., Shaw, S. A., Bao, D. H., Wei, F. L., Zhou, T., Eastgate, M. D., et al. Decarboxylative alkenylation Nature  2017 545:213-218  DOI:10.1038/nature22307  PMID:28424520
    • Malins, L. R., deGruyter, J. N., Robbins, K. J., Scola, P. M., Eastgate, M. D., Ghadiri, M. R., Baran, P. S. Peptide macrocyclization inspired by non-ribosomal imine natural products Journal of the American Chemical Society  2017 139:5233-5241  DOI:10.1021/jacs.7b01624  PMID:28326777  PMCID:PMC5391502
    • Sandfort, F., O'Neill, M. J., Cornella, J., Wimmer, L., Baran, P. S. Alkyl-(hetero)aryl bond formation via decarboxylative cross-coupling: A systematic analysis Angewandte Chemie-International Edition  2017 56:3319-3323  DOI:10.1002/anie.201612314  PMID:28185368
    • Lopchuk, J. M., Fjelbye, K., Kawamata, Y., Malins, L. R., Pan, C. M., Gianatassio, R., Wang, J., Prieto, L., Bradow, J., Brandt, T. A., Collins, M. R., Elleraas, J., et al. Strain-release heteroatom functionalization: Development, scope, and stereospecificity Journal of the American Chemical Society  2017 139:3209-3226  DOI:10.1021/jacs.6b13229  PMID:28140573  PMCID:PMC5334783
    • Lo, J. C., Kim, D., Pan, C. M., Edwards, J. T., Yabe, Y., Gui, J. H., Qin, T., Gutierrez, S., Giacoboni, J., Smith, M. W., Holland, P. L., Baran, P. S. Fe-catalyzed C-C bond construction from olefins via radicals Journal of the American Chemical Society  2017 139:2484-2503  DOI:10.1021/jacs.6b13155  PMID:28094980  PMCID:PMC5314431
    • Chu, H., Smith, J. M., Felding, J., Baran, P. S. Scalable synthesis of (-)-thapsigargin ACS Central Science  2017 3:47-51  DOI:10.1021/acscentsci.6b00313  PMID:28149952  PMCID:PMC5269647
    • Qin, T., Malins, L. R., Edwards, J. T., Merchant, R. R., Novak, A. J. E., Zhong, J. Z., Mills, R. B., Yan, M., Yuan, C., Eastgate, M. D., Baran, P. S. Nickel-catalyzed barton decarboxylation and giese reactions: a practical take on classic transforms Angewandte Chemie-International Edition  2017 56:260-265  DOI:10.1002/anie.201609662  PMID:27981703  PMCID:PMC5295468
    • Tian, M., Yan, M., Baran, P. S. 11-step total synthesis of araiosamines Journal of the American Chemical Society  2016 138:14234-14237  DOI:10.1021/jacs.6b09701  PMID:27748593  PMCID:PMC5095662
    • Yan, M., Lo, J. C., Edwards, J. T., Baran, P. S. Radicals: reactive intermediates with translational potential Journal of the American Chemical Society  2016 138:12692-12714  DOI:10.1021/jacs.6b08856  PMID:27631602  PMCID:PMC5054485
    • Toriyama, F., Cornella, J., Wimmer, L., Chen, T. G., Dixon, D. D., Creech, G., Baran, P. S. Redox-active esters in Fe-catalyzed C-C coupling Journal of the American Chemical Society  2016 138:11132-11135  DOI:10.1021/jacs.6b07172  PMID:27548696  PMCID:PMC5016806
    • Quesnelle, C. A., Gill, P., Kim, S. H., Chen, L., Zhao, Y., Fink, B. E., Saulnier, M., Frennesson, D., DeMartino, M. P., Baran, P. S., Gavai, A. V. A practical approach for enantio- and diastereocontrol in the synthesis of 2,3-disubstituted succinic acid esters: synthesis of the pan-Notch inhibitor BMS-906024 Synlett  2016 27:2254-2258  DOI:10.1055/s-0035-1561636
    • Gnaim, S., Scomparin, A., Li, X., Baran, P. S., Rader, C., Satchi-Fainaro, R., Shabat, D. Tagging the untaggable: a difluoroalkyl-sulfinate ketone-based reagent for direct C-H functionalization of bioactive heteroarenes Bioconjugate Chemistry  2016 27:1965-1971  DOI:10.1021/acs.bioconjchem.6b00382  PMID:27494153
    • Wang, J., Qin, T., Chen, T. G., Wimmer, L., Edwards, J. T., Cornella, J., Vokits, B., Shaw, S. A., Baran, P. S. Nickel-catalyzed cross-coupling of redox-active esters with boronic acids Angewandte Chemie-International Edition  2016 55:9675-9678  DOI:10.1002/anie.201605463  PMID:27380912  PMCID:PMC5232357
    • Cernijenko, A., Risgaard, R., Baran, P. S. 11-step total synthesis of (-)-maoecrystal V Journal of the American Chemical Society  2016 138:9425-9428  DOI:10.1021/jacs.6b06623  PMID:27457680  PMCID:PMC4974602
    • Yuan, C., Jin, Y., Wilde, N. C., Baran, P. S. Short, enantioselective total synthesis of highly oxidized taxanes Angewandte Chemie-International Edition  2016 55:8280-8284  DOI:10.1002/anie.201602235  PMID:27240325  PMCID:PMC4972021
    • Martinez, L. P., Umemiya, S., Wengryniuk, S. E., Baran, P. S. 11-step total synthesis of pallambins C and D Journal of the American Chemical Society  2016 138:7536-7539  DOI:10.1021/jacs.6b04816  PMID:27284962  PMCID:PMC4919752
    • Horn, E. J., Rosen, B. R., Baran, P. S. Synthetic organic electrochemistry: an enabling and innately sustainable method ACS Central Science  2016 2:302-308  DOI:10.1021/acscentsci.6b00091  PMID:27280164  PMCID:PMC4882743
    • Yan, M., Baran, P. S. Drug discovery: Fighting evolution with chemical synthesis Nature  2016 533:326-327  PMID:27193674
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    • Ji, Y. N., Brueckl, T., Baxter, R. D., Fujiwara, Y., Seiple, I. B., Su, S., Blackmond, D. G., Baran, P. S. Innate C-H trifluoromethylation of heterocycles Proceedings of the National Academy of Sciences of the United States of America  2011 108:14411-14415  DOI:10.1073/pnas.1109059108  PMID:21844378  PMCID:PMC3167544
    • Shi, J., Manolikakes, G., Yeh, C. H., Guerrero, C. A., Shenvi, R. A., Shigehisa, H., Baran, P. S. Scalable synthesis of cortistatin A and related structures Journal of the American Chemical Society  2011 133:8014-8027  DOI:10.1021/ja202103e  PMID:21539314  PMCID:PMC3119343
    • Cherney, E. C., Baran, P. S. Terpenoid-alkaloids: Their biosynthetic twist of fate and total synthesis Israel Journal of Chemistry  2011 51:391-405  DOI:10.1002/ijch.201100005  PMID:26207071  PMCID:PMC4508874
    • Fujiwara, Y., Domingo, V., Seiple, I. B., Gianatassio, R., Del Bel, M., Baran, P. S. Practical C-H functionalization of quinones with boronic acids Journal of the American Chemical Society  2011 133:3292-3295  DOI:10.1021/ja111152z  PMID:21341741  PMCID:PMC3964812
    • Jessing, M., Baran, P. S. Oxidative coupling of indoles with 3-oxindoles Heterocycles  2011 82:1739-1745  DOI:10.3987/com-10-s(e)127
    • Lin, D. W., Masuda, T., Biskup, M. B., Nelson, J. D., Baran, P. S. Synthesis-guided structure revision of the sarcodonin, sarcoviolin, and hydnellin natural product family Journal of Organic Chemistry  2011 76:1013-1030  DOI:10.1021/jo102228j  PMID:21250718  PMCID:PMC3089814
    • Gutekunst, W. R., Baran, P. S. C-H functionalization logic in total synthesis Chemical Society Reviews  2011 40:1976-1991  DOI:10.1039/c0cs00182a  PMID:21298176
    • Newhouse, T., Baran, P. S. If C-H bonds could talk: Selective C-H bond oxidation Angewandte Chemie-International Edition  2011 50:3362-3374  DOI:10.1002/anie.201006368  PMID:21413105  PMCID:PMC3980681
    • Foo, K., Newhouse, T., Mori, I., Takayama, H., Baran, P. S. Total synthesis guided structure elucidation of (+)-psychotetramine Angewandte Chemie-International Edition  2011 50:2716-2719  DOI:10.1002/anie.201008048  PMID:21387473  PMCID:PMC3365487
    • Schallenberger, M. A., Newhouse, T., Baran, P. S., Romesberg, F. E. The psychotrimine natural products have antibacterial activity against gram-positive bacteria and act via membrane disruption Journal of Antibiotics  2010 63:685-687  DOI:10.1038/ja.2010.107  PMID:20924383  PMCID:PMC3979425
    • Seiple, I. B., Su, S., Rodriguez, R. A., Gianatassio, R., Fujiwara, Y., Sobel, A. L., Baran, P. S. Direct C-H arylation of electron-deficient heterocycles with arylboronic acids Journal of the American Chemical Society  2010 132:13194-13196  DOI:10.1021/ja1066459  PMID:20812741  PMCID:PMC2946225
    • Gaich, T., Baran, P. S. Aiming for the ideal synthesis Journal of Organic Chemistry  2010 75:4657-4673  DOI:10.1021/jo1006812  PMID:20540516
    • Ishihara, Y., Baran, P. S. Two-phase terpene total synthesis: historical perspective and application to the Taxol problem Synlett  2010 1733-1745  DOI:10.1055/s-0030-1258123
    • Chen, K., Ishihara, Y., Galan, M. M., Baran, P. S. Total synthesis of eudesmane terpenes: cyclase phase Tetrahedron  2010 66:4738-4744  DOI:10.1016/j.tet.2010.02.088
    • Newhouse, T., Lewis, C. A., Eastman, K. J., Baran, P. S. Scalable total syntheses of N-linked tryptamine dimers by direct indole-aniline coupling: Psychotrimine and kapakahines B and F Journal of the American Chemical Society  2010 132:7119-7137  DOI:10.1021/ja1009458  PMID:20426477  PMCID:PMC2874090
    • Schultz, A. W., Lewis, C. A., Luzung, M. R., Baran, P. S., Moore, B. S. Functional characterization of the cyclomarin/cyclomarazine prenyltransferase cymd directs the biosynthesis of unnatural cyclic peptides Journal of Natural Products  2010 73:373-377  DOI:10.1021/np9006876  PMID:20055491  PMCID:PMC2846197
    • Cipres, A., O'Malley, D. P., Li, K., Finlay, D., Baran, P. S., Vuori, K. Sceptrin, a marine natural compound, inhibits cell motility in a variety of cancer cell lines ACS Chemical Biology  2010 5:195-202  DOI:10.1021/cb900240k  PMID:20030414  PMCID:PMC2825093
    • Sella, E., Weinstain, R., Erez, R., Burns, N. Z., Baran, P. S., Shabat, D. Sulfhydryl-based dendritic chain reaction Chemical Communications  2010 46:6575-6577  DOI:10.1039/c0cc02195d  PMID:20714571
    • Seiple, I. B., Su, S., Young, I. S., Lewis, C. A., Yamaguchi, J., Baran, P. S. Total synthesis of palau'amine Angewandte Chemie-International Edition  2010 49:1095-1098  DOI:10.1002/anie.200907112  PMID:20041464  PMCID:PMC3367661
    • Maimone, T. J., Shi, J., Ashida, S., Baran, P. S. Total synthesis of vinigrol Journal of the American Chemical Society  2009 131:17066-17067  DOI:10.1021/ja908194b  PMID:19877628  PMCID:PMC2787793
    • Krawczuk, P. J., Schone, N., Baran, P. S. A synthesis of the carbon skeleton of maoecrystal v Organic Letters  2009 11:4774-4776  DOI:10.1021/ol901963v  PMID:19795876  PMCID:PMC2783297
    • Weinstain, R., Baran, P. S., Shabat, D. Activity-linked labeling of enzymes by self-immolative polymers Bioconjugate Chemistry  2009 20:1783-1791  DOI:10.1021/bc9002037  PMID:19689155
    • Burns, N. Z., Jessing, M., Baran, P. S. Total synthesis of haouamine A: The indeno-tetrahydropyridine core Tetrahedron  2009 65:6600-6610  DOI:10.1016/j.tet.2009.05.075  PMID:20161191  PMCID:PMC2728496
    • Hafensteiner, B. D., Escribano, M., Petricci, E., Baran, P. S. An improved synthesis of alpha,beta-unsaturated nitrones relevant to the stephacidins and analogs thereof Bioorganic & Medicinal Chemistry Letters  2009 19:3808-3810  DOI:10.1016/j.bmcl.2009.04.045  PMID:19423345  PMCID:PMC2709696
    • Burns, N. Z., Krylova, I. N., Hannoush, R. N., Baran, P. S. Scalable total synthesis and biological evaluation of haouamine a and its atropisomer Journal of the American Chemical Society  2009 131:9172-9173  DOI:10.1021/ja903745s  PMID:19530671  PMCID:PMC2740483
    • Chen, K., Baran, P. S. Total synthesis of eudesmane terpenes by site-selective C-H oxidations Nature  2009 459:824-828  DOI:10.1038/nature08043  PMID:19440196
    • Young, I. S., Baran, P. S. Protecting-group-free synthesis as an opportunity for invention Nature Chemistry  2009 1:193-205  DOI:10.1038/nchem.216  PMID:21378848
    • Newhouse, T., Lewis, C. A., Baran, P. S. Enantiospecific total syntheses of kapakahines B and F Journal of the American Chemical Society  2009 131:6360-6361  DOI:10.1021/ja901573x  PMID:19374357
    • Eastman, K., Baran, P. S. A simple method for the direct arylation of indoles Tetrahedron  2009 65:3149-3154  DOI:10.1016/j.tet.2008.09.028
    • Shenvi, R. A., O'Malley, D. P., Baran, P. S. Chemoselectivity: The mother of invention in total synthesis Accounts of Chemical Research  2009 42:530-541  DOI:10.1021/ar800182r  PMID:19182997  PMCID:PMC2765532
    • Luzung, M. R., Lewis, C. A., Baran, P. S. Direct, chemoselective N-tert-prenylation of indoles by C-H functionalization Angewandte Chemie-International Edition  2009 48:7025-7029  DOI:10.1002/anie.200902761  PMID:19701955  PMCID:PMC2886517
    • Burns, N. Z., Baran, P. S., Hoffmann, R. W. Redox economy in organic synthesis Angewandte Chemie-International Edition  2009 48:2854-2867  DOI:10.1002/anie.200806086  PMID:19294720
    • Shi, J., Shigehisa, H., Guerrero, C. A., Shenvi, R. A., Li, C. C., Baran, P. S. Stereodivergent synthesis of 17-alpha and 17-beta-alpharyl steroids: Application and biological evaluation of D-ring cortistatin analogues Angewandte Chemie-International Edition  2009 48:4328-4331  DOI:10.1002/anie.200901116  PMID:19434636  PMCID:PMC3495592
    • Chen, K., Eschenmoser, A., Baran, P. S. Strain release in C-H bond activation? Angewandte Chemie-International Edition  2009 48:9705-9708  DOI:10.1002/anie.200904474  PMID:19937877  PMCID:PMC2879134
    • Newhouse, T., Baran, P. S., Hoffmann, R. W. The economies of synthesis Chemical Society Reviews  2009 38:3010-3021  DOI:10.1039/b821200g  PMID:19847337  PMCID:PMC2880393
    • Perry-Feigenbaum, R., Baran, P. S., Shabat, D. The pyridinone-methide elimination Organic & Biomolecular Chemistry  2009 7:4825-4828  DOI:10.1039/b915265b  PMID:19907770
    • Richter, J. M., Ishihara, Y., Masuda, T., Whitefield, B. W., Llamas, T., Pohjakallio, A., Baran, P. S. Enantiospecific total synthesis of the hapalindoles, fischerindoles, and welwitindolinones via a redox economic approach Journal of the American Chemical Society  2008 130:17938-17954  DOI:10.1021/ja806981k  PMID:19035635  PMCID:PMC2634302
    • Su, S., Seiple, I. B., Young, I. S., Baran, P. S. Total syntheses of (+/-)-massadine and massadine chloride Journal of the American Chemical Society  2008 130:16490-16491  DOI:10.1021/ja8074852  PMID:19049446  PMCID:PMC2913575
    • DeMartino, M. P., Chen, K., Baran, P. S. Intermolecular enolate heterocoupling: Scope, mechanism, and application Journal of the American Chemical Society  2008 130:11546-11560  DOI:10.1021/ja804159y  PMID:18680297
    • Newhouse, T., Baran, P. S. Total synthesis of (+/-)-psychotrimine Journal of the American Chemical Society  2008 130:10886-10887  DOI:10.1021/ja8042307  PMID:18656919
    • Chen, K., Richter, J. M., Baran, P. S. 1,3-diol synthesis via controlled, radical-mediated C-H functionalization Journal of the American Chemical Society  2008 130:7247-7249  DOI:10.1021/ja802491q  PMID:18481847
    • Shenvi, R. A., Guerrero, C. A., Shi, J., Li, C. C., Baran, P. S. Synthesis of (+)-cortistatin A Journal of the American Chemical Society  2008 130:7241-7243  DOI:10.1021/ja8023466  PMID:18479104  PMCID:PMC2652360
    • Maimone, T. J., Voica, A. F., Baran, P. S. A concise approach to vinigrol Angewandte Chemie-International Edition  2008 47:3054-3056  DOI:10.1002/anie.200800167  PMID:18338349
    • Burns, N. Z., Baran, P. S. On the origin of the haouamine alkaloids Angewandte Chemie-International Edition  2008 47:205-208  DOI:10.1002/anie.200704576  PMID:18038444
    • Yamaguchi, J., Seiple, I. B., Young, I. S., O'Malley, D. P., Maue, M., Baran, P. S. Synthesis of 1,9-dideoxy-pre-axinellamine Angewandte Chemie-International Edition  2008 47:3578-3580  DOI:10.1002/anie.200705913  PMID:18357598
    • O'Malley, D. P., Yamaguchi, J., Young, I. S., Seiple, I. B., Baran, P. S. Total synthesis of (+/-)-axinellamines A and B Angewandte Chemie-International Edition  2008 47:3581-3583  DOI:10.1002/anie.200801138  PMID:18357612
    • Richter, J. M., Whitefield, B. W., Maimone, T. J., Lin, D. W., Castroviejo, M. P., Baran, P. S. Scope and mechanism of direct indole and pyrrole couplings adjacent to carbonyl compounds: Total synthesis of acremoauxin A and oxazinin 3 Journal of the American Chemical Society  2007 129:12857-12869  DOI:10.1021/ja074392m  PMID:17900115  PMCID:PMC2631414
    • Maimone, T. J., Baran, P. S. Modern synthetic efforts toward biologically active terpenes Nature Chemical Biology  2007 3:396-407  DOI:10.1038/nchembio.2007.1  PMID:17576427
    • O'Malley, D. P., Li, K., Maue, M., Zografos, A. L., Baran, P. S. Total synthesis of dimeric pyrrole-imidazole alkaloids: Sceptrin, ageliferin, nagelamide e, oxysceptrin, nakamuric acid, and the axinellamine carbon skeleton Journal of the American Chemical Society  2007 129:4762-4775  DOI:10.1021/ja069035a  PMID:17375928
    • Baran, P. S.*, Maimone, T. J.*, Richter, J. M. Total synthesis of marine natural products without using protecting groups Nature  2007 446:404-408  DOI:10.1038/nature05569  PMID:17377577 (* = equal contribution)
    • Baran, P. S.*, Maimone, T. J.* Organic chemistry: A tuxedo for iodine atoms Nature  2007 445:826-827  DOI:10.1038/445826a  PMID:17314962 (* = equal contribution)
    • Grube, A., Immel, S., Baran, P. S., Kock, M. Massadine chloride: A biosynthetic precursor of massadine and stylissadine Angewandte Chemie-International Edition  2007 46:6721-6724  DOI:10.1002/anie.200701935  PMID:17685369
    • Kock, M., Grube, A., Seiple, I. B., Baran, P. S. The pursuit of palau'amine Angewandte Chemie-International Edition  2007 46:6586-6594  DOI:10.1002/anie.200701798  PMID:17724780
    • Baran, P. S., Shenvi, R. A., Nguyen, S. A. One-step synthesis of 4,5-disubstituted pyrimidines using commercially available and inexpensive reagents Heterocycles  2006 70:581-586  DOI:10.3987/COM-06-S(W)27
    • Baran, P. S., Shenvi, R. A. Total synthesis of (+/-)-chartelline C Journal of the American Chemical Society  2006 128:14028-14029  DOI:10.1021/ja0659673  PMID:17061876
    • Baran, P. S.*, Hafensteiner, B. D.*, Ambhaikar, N. B., Guerrero, C. A., Gallagher, J. D. Enantioselective total synthesis of avrainvillamide and the stephacidins Journal of the American Chemical Society  2006 128:8678-8693  DOI:10.1021/ja061660s  PMID:16802835 (* = equal contribution)
    • Baran, P. S.*, Burns, N. Z.* Total synthesis of (+/-)-haouamine A Journal of the American Chemical Society  2006 128:3908-3909  DOI:10.1021/ja0602997  PMID:16551088 (* = equal contribution)
    • Baran, P. S.*, DeMartino, M. P.* Intermolecular oxidative enolate heterocoupling Angewandte Chemie-International Edition  2006 45:7083-7086  DOI:10.1002/anie.200603024  PMID:17009377 (* = equal contribution)
    • Northrop, B. H., O'Malley, D. P., Zografos, A. L., Baran, P. S., Houk, K. N. Mechanism of the vinylcyclobutane rearrangement of sceptrin to ageliferin and nagelamide E Angewandte Chemie-International Edition  2006 45:4126-4130  DOI:10.1002/anie.200600514  PMID:16703636
    • Baran, P. S., Ambhaikar, N. B., Guerrero, C. A., Hafensteiner, B. D., Lin, D. W., Richter, J. M. Oxidative C-C bond formation in heterocyclic chemistry Arkivoc  2006 310-325
    • Baran, P. S., Li, K., O'Malley, D. R., Mitsos, C. Short, enantioselective total synthesis of sceptrin and ageliferin by programmed oxaquadricyclane fragmentation Angewandte Chemie-International Edition  2006 45:249-252  DOI:10.1002/anie.200503374  PMID:16317782
    • Baran, P. S.*, Richter, J. M.* Enantioselective total syntheses of welwitindolinone A and fischerindoles I and G Journal of the American Chemical Society  2005 127:15394-15396  DOI:10.1021/ja056171r  PMID:16262402 (* = equal contribution)
    • Baran, P. S., Shenvi, R. A., Mitsos, C. A. A remarkable ring contraction en route to the chartelline alkaloids Angewandte Chemie-International Edition  2005 44:3714-3717  DOI:10.1002/anie.200500522  PMID:15900528
    • Baran, P. S.*, Richter, J. M.*, Lin, D. W. Direct coupling of pyrroles with carbonyl compounds: Short enantioselective synthesis of (S)-ketorolac Angewandte Chemie-International Edition  2005 44:609-612  DOI:10.1002/anie.200462048  PMID:15584071 (* = equal contribution)
    • Baran, P. S.*, Guerrero, C. A.*, Ambhaikar, N. B., Hafensteiner, B. D. Short, enantioselective total synthesis of stephacidin A Angewandte Chemie-International Edition  2005 44:606-609  DOI:10.1002/anie.200461864  PMID:15586393 (* = equal contribution)
    • Baran, P. S.*, Guerrero, C. A.*, Hafensteiner, B. D., Ambhaikar, N. B. Total synthesis of avrainvillamide (CJ-17,665) and stephacidin B Angewandte Chemie-International Edition  2005 44:3892-3895  DOI:10.1002/anie.200500655  PMID:15900526 (* = equal contribution)
    • Baran, P. S.*, Richter, J. M.* Direct coupling of indoles with carbonyl compounds: Short, enantioselective, gram-scale synthetic entry into the hapalindole and fischerindole alkaloid families Journal of the American Chemical Society  2004 126:7450-7451  DOI:10.1021/ja047874w  PMID:15198586 (* = equal contribution)
    • Baran, P. S., Zografos, A. L., O'Malley, D. P. Short total synthesis of (+/-)-sceptrin Journal of the American Chemical Society  2004 126:3726-3727  DOI:10.1021/ja049648s  PMID:15038721
    • Baran, P. S.*, O'Malley, D. P.*, Zografos, A. L. Sceptrin as a potential biosynthetic precursor to complex pyrrole-imidazole alkaloids: The total synthesis of ageliferin Angewandte Chemie-International Edition  2004 43:2674-2677  DOI:10.1002/anie.200453937  PMID:18629987 (* = equal contribution)
    • Baran, P. S., Guerrero, C. A., Corey, E. J. The first method for protection-deprotection of the indole 2,3-pi bond Organic Letters  2003 5:1999-2001  DOI:10.1021/ol034634x  PMID:12762706
    • Baran, P. S., Guerrero, C. A., Corey, E. J. Short, enantioselective total synthesis of okaramine n Journal of the American Chemical Society  2003 125:5628-5629  DOI:10.1021/ja034491+  PMID:12733890
    • Baran, P. S., Corey, E. J. A short synthetic route to (+)-austamide, (+)-deoxyisoaustamide, and (+)-hydratoaustamide from a common precursor by a novel palladium-mediated indole -> dihydroindoloazocine cyclization Journal of the American Chemical Society  2002 124:7904-7905  DOI:10.1021/ja026663t  PMID:12095326
    • degree-related publication Nicolaou, K. C., Montagnon, T., Ulven, T., Baran, P. S., Zhong, Y. L., Sarabia, F. Novel chemistry of alpha-tosyloxy ketones: Applications to the solution- and solid-phase synthesis of privileged heterocycle and enediyne libraries Journal of the American Chemical Society  2002 124:5718-5728  DOI:10.1021/ja012146j  PMID:12010045
    • degree-related publication Nicolaou, K. C.*, Baran, P. S.*, Zhong, Y. L., Sugita, K. Iodine(V) reagents in organic synthesis. Part 1. Synthesis of polycyclic heterocycles via Dess-Martin periodinane-mediated cascade cyclization: Generality, scope, and mechanism of the reaction Journal of the American Chemical Society  2002 124:2212-2220  DOI:10.1021/ja012124x  PMID:11878975 (* = equal contribution)
    • degree-related publication Nicolaou, K. C., Sugita, K., Baran, P. S., Zhong, Y. L. Iodine(V) reagents in organic synthesis. Part 2. Access to complex molecular architectures via Dess-Martin periodinane-generated o-imidoquinones Journal of the American Chemical Society  2002 124:2221-2232  DOI:10.1021/ja012125p  PMID:11878976
    • degree-related publication Nicolaou, K. C.*, Baran, P. S.*, Zhong, Y. L., Barluenga, S., Hunt, K. W., Kranich, R., Vega, J. A. Iodine(V) reagents in organic synthesis. Part 3. New routes to heterocyclic compounds via o-iodoxybenzoic acid-mediated cyclizations: Generality, scope, and mechanism Journal of the American Chemical Society  2002 124:2233-2244  DOI:10.1021/ja012126h  PMID:11878977 (* = equal contribution)
    • degree-related publication Nicolaou, K. C., Montagnon, T., Baran, P. S., Zhong, Y. L. Iodine(V) reagents in organic synthesis. Part 4. O-iodoxybenzoic acid as a chemospecific tool for single electron transfer-based oxidation processes Journal of the American Chemical Society  2002 124:2245-2258  DOI:10.1021/ja012127+  PMID:11878978
    • degree-related publication Nicolaou, K. C., Jung, J., Yoon, W. H., Fong, K. C., Choi, H. S., He, Y., Zhong, Y. L., Baran, P. S. Total synthesis of the CP-molecules (CP-263,114 and CP-225,917, phomoidrides B and A). 1. Racemic and asymmetric synthesis of bicyclo 4.3.1 key building blocks Journal of the American Chemical Society  2002 124:2183-2189  DOI:10.1021/ja012010l  PMID:11878972
    • degree-related publication Nicolaou, K. C.*, Baran, P. S.*, Zhong, Y. L., Fong, K. C., Choi, K. S. Total synthesis of the CP-molecules (CP-263,114 and CP-225,917, phomoidrides B and A). 2. Model studies for the construction of key structural elements and first-generation strategy Journal of the American Chemical Society  2002 124:2190-2201  DOI:10.1021/ja012011d  PMID:11878973 (* = equal contribution)
    • degree-related publication Nicolaou, K. C., Zhong, Y. L., Baran, P. S., Jung, J., Choi, H. S., Yoon, W. H. Total synthesis of the CP-molecules (CP-263,114 and CP-225,917, phomoidrides B and A). 3. Completion and synthesis of advanced analogues Journal of the American Chemical Society  2002 124:2202-2211  DOI:10.1021/ja0120126  PMID:11878974
    • degree-related publication Nicolaou, K. C., Montagnon, T., Baran, P. S. HIO3 and I2O5: mild and selective alternative reagents to IBX for the dehydrogenation of aldehydes and ketones Angewandte Chemie-International Edition  2002 41:1386-1389  DOI:10.1002/1521-3773(20020415)41:8<1386::aid-anie1386>3.0.co;2-v  PMID:19750773
    • degree-related publication Nicolaou, K. C., Montagnon, T., Baran, P. S. Modulation of the reactivity profile of IBX by ligand complexation: Ambient temperature dehydrogenation of aldehydes and ketones to alpha,beta-unsaturated carbonyl compounds Angewandte Chemie-International Edition  2002 41:993-996  DOI:10.1002/1521-3773(20020315)41:6<993::aid-anie993>3.0.co;2-u  PMID:12491291
    • degree-related publication Nicolaou, K. C.*, Baran, P. S.* The CP molecule labyrinth: a paradigm of how endeavors in total synthesis lead to discoveries and inventions in organic synthesis Angewandte Chemie-International Edition  2002 41:2678-2720  DOI:10.1002/1521-3773(20020802)41:15<2678::aid-anie2678>3.0.co;2-v  PMID:12203464 (* = equal contribution)
    • MacMahon, S., Fong, R., 2nd, Baran, P. S., Safonov, I., Wilson, S. R., Schuster, D. I. Synthetic approaches to a variety of covalently linked porphyrin-fullerene hybrids Journal of Organic Chemistry  2001 66:5449-5455  DOI:10.1021/jo010317x  PMID:11485469
    • degree-related publication Nicolaou, K. C.*, Baran, P. S.*, Zhong, Y. L. Selective oxidation at carbon adjacent to aromatic systems with IBX Journal of the American Chemical Society  2001 123:3183-3185  DOI:10.1021/ja004218x  PMID:11457049 (* = equal contribution)
    • degree-related publication Nicolaou, K. C.*, Baran, P. S.*, Kranich, R., Zhong, Y. L., Sugita, K., Zou, N. Mechanistic studies of periodinane-mediated reactions of anilides and related systems Angewandte Chemie-International Edition  2001 40:202-206  DOI:10.1002/1521-3773(20010105)40:1<202::aid-anie202>3.0.co;2-3  PMID:11169713 (* = equal contribution)
    • degree-related publication Nicolaou, K. C., Sugita, K., Baran, P. S., Zhong, Y. L. New synthetic technology for the construction of N-containing quinones and derivatives thereof: Total synthesis of epoxyquinomycin B Angewandte Chemie-International Edition  2001 40:207-210  DOI:10.1002/1521-3773(20010105)40:1<207::aid-anie207>3.3.co;2-b  PMID:11169714
    • degree-related publication Nicolaou, K. C., Zhong, Y. L., Baran, P. S., Sugita, K. Rapid access to complex molecular architectures via o-Azaquinones Angewandte Chemie-International Edition  2001 40:2145-2149  DOI:10.1002/1521-3773(20010601)40:11<2145::aid-anie2145>3.0.co;2-m  PMID:11433472
    • degree-related publication Nicolaou, K. C.*, Baran, P. S.*, Zhong, Y. L. Novel solution- and solid-phase chemistry of α-sulfonated ketones applicable to combinatorial chemistry Journal of the American Chemical Society  2000 122:10246-10248  DOI:10.1021/ja002768p (* = equal contribution)
    • degree-related publication Nicolaou, K. C., Zhong, Y. L., Baran, P. S. A new method for the one-step synthesis of alpha,beta-unsaturated carbonyl systems from saturated alcohols and carbonyl compounds Journal of the American Chemical Society  2000 122:7596-7597  DOI:10.1021/ja001825b
    • degree-related publication Nicolaou, K. C., Vassilikogiannakis, G., Kranich, R., Baran, P. S., Zhong, Y. L., Natarajan, S. New synthetic technology for the mild and selective one-carbon homologation of hindered aldehydes in the presence of ketones Organic Letters  2000 2:1895-1898  DOI:10.1021/ol000102u  PMID:10891185
    • degree-related publication Nicolaou, K. C., Vassilikogiannakis, G., Simonsen, K. B., Baran, P. S., Zhong, Y. L., Vidali, V. P., Pitsinos, E. N., Couladouros, E. A. Biomimetic total synthesis of bisorbicillinol, bisorbibutenolide, trichodimerol, and designed analogues of the bisorbicillinoids Journal of the American Chemical Society  2000 122:3071-3079  DOI:10.1021/ja9942843
    • degree-related publication Nicolaou, K. C., Zhong, Y. L., Baran, P. S. New synthetic technology for the rapid construction of novel heterocycles. Part 1. The reaction of Dess-Martin periodinane with anilides and related compounds Angewandte Chemie-International Edition  2000 39:622-625  DOI:10.1002/(sici)1521-3773(20000204)39:3<622::aid-anie622>3.3.co;2-2  PMID:10671278
    • degree-related publication Nicolaou, K. C., Zhong, Y. L., Baran, P. S. New synthetic technology for the rapid construction of novel heterocycles. Part 2. The reaction of IBX with anilides and related compounds Angewandte Chemie-International Edition  2000 39:625-628  DOI:10.1002/(sici)1521-3773(20000204)39:3<625::aid-anie625>3.0.co;2-#  PMID:10671279
    • degree-related publication Nicolaou, K. C.*, Baran, P. S.*, Zhong, Y. L., Vega, J. A. Novel IBX-mediated processes for the synthesis of amino sugars and libraries thereof Angewandte Chemie-International Edition  2000 39:2525-2529  DOI:10.1002/1521-3773(20000717)39:14<2525::aid-anie2525>3.0.co;2-1  PMID:10941125 (* = equal contribution)
    • degree-related publication Nicolaou, K. C., Jung, J. K., Yoon, W. H., He, Y., Zhong, Y. L., Baran, P. S. The absolute configuration and asymmetric total synthesis of the CP molecules (CP-263,114 and CP-225,917, phomoidrides B and A) Angewandte Chemie-International Edition  2000 39:1829-1832  DOI:10.1002/(sici)1521-3773(20000515)39:10<1829::aid-anie1829>3.0.co;2-6  PMID:10934377
    • degree-related publication Nicolaou, K. C., Vourloumis, D., Winssinger, N., Baran, P. S. The art and science of total synthesis at the dawn of the twenty-first century Angewandte Chemie-International Edition  2000 39:44-122  DOI:10.1002/(sici)1521-3773(20000103)39:1<44::aid-anie44>3.3.co;2-c  PMID:10649349
    • degree-related publication Nicolaou, K. C., Jautelat, R., Vassilikogiannakis, G., Baran, P. S., Simonsen, K. B. Studies towards trichodimerol: Novel cascade reactions and polycyclic frameworks Chemistry-a European Journal  1999 5:3651-3665  DOI:10.1002/(sici)1521-3765(19991203)5:12<3651::aid-chem3651>3.3.co;2-p
    • degree-related publication Nicolaou, K. C.*, Baran, P. S.*, Zhong, Y. L., Choi, H. S., Fong, K. C., He, Y., Yoon, W. H. New synthetic technology for the synthesis of hindered α-diazoketones via acyl mesylates Organic Letters  1999 1:883-886  DOI:10.1021/ol990790l  PMID:10823217 (* = equal contribution)
    • degree-related publication Nicolaou, K. C.*, He, Y.*, Fong, K. C., Yoon, W. H., Choi, H. S., Zhong, Y. L., Baran, P. S. Novel strategies to construct the γ-hydroxy lactone moiety of the CP molecules. Synthesis of the CP-225,917 core skeleton Organic Letters  1999 1:63-66  DOI:10.1021/ol990551y  PMID:10822534 (* = equal contribution)
    • degree-related publication Nicolaou, K. C.*, Baran, P. S.*, Jautelat, R., He, Y., Fong, K. C., Choi, H. S., Yoon, W. H., Zhong, Y. L. A novel route to the fused maleic anhydride moiety of CP molecules Angewandte Chemie-International Edition  1999 38:549-552  DOI:10.1002/(sici)1521-3773(19990215)38:4<549::aid-anie549>3.0.co;2-o (* = equal contribution)
    • degree-related publication Nicolaou, K. C., Simonsen, K. B., Vassilikogiannakis, G., Baran, P. S., Vidali, V. P., Pitsinos, E. N., Couladouros, E. A. Biomimetic explorations towards the bisorbicillinoids: total synthesis of bisorbicillinol, bisorbibutenolide, and trichodimerol Angewandte Chemie-International Edition  1999 38:3555-3559  DOI:10.1002/(sici)1521-3773(19991203)38:23<3555::aid-anie3555>3.0.co;2-z  PMID:10602241
    • Baran, P. S., Khan, A. U., Schuster, D. I., Wilson, S. R. Some photophysical properties of nanotubes Fullerene Science and Technology  1999 7:921-925  DOI:10.1080/10641229909351388
    • degree-related publication Nicolaou, K. C.*, Baran, P. S.*, Zhong, Y. L., Fong, K. C., He, Y., Yoon, W. H., Choi, H. S. Total synthesis of the CP molecules CP-225,917 and CP-263,114. Part 2: Evolution of the final strategy Angewandte Chemie-International Edition  1999 38:1676-1678  DOI:10.1002/(sici)1521-3773(19990601)38:11<1676::aid-anie1676>3.0.co;2-t (* = equal contribution)
    • degree-related publication Nicolaou, K. C.*, Baran, P. S.*, Zhong, Y. L., Choi, H. S., Yoon, W. H., He, Y., Fong, K. C. Total synthesis of the CP molecules CP-263,114 and CP-225,917. Part 1: Synthesis of key intermediates and intelligence gathering Angewandte Chemie-International Edition  1999 38:1669-1675  DOI:10.1002/(sici)1521-3773(19990601)38:11<1669::aid-anie1669>3.0.co;2-d (* = equal contribution)
    • Schuster, D. I.*, Baran, P. S.*, Hatch, R. K., Khan, A. U., Wilson, S. R. The role of singlet oxygen in the photochemical formation of c60o Chemical Communications  1998 2493-2494  DOI:10.1039/a806603e (* = equal contribution)
    • Safonov, I. G., Baran, P. S., Schuster, D. I. Synthesis and photophysics of a novel porphyrin-c-60 hybrid Tetrahedron Letters  1997 38:8133-8136  DOI:10.1016/s0040-4039(97)10184-8
    • Baran, P. S., Monaco, R. R., Khan, A. U., Schuster, D. I., Wilson, S. R. Synthesis and cation-mediated electronic interactions of two novel classes of porphyrin-fullerene hybrids Journal of the American Chemical Society  1997 119:8363-8364  DOI:10.1021/ja970486s

featured in

  • Chemists Find More Efficient Total Synthesis Route To Ingenol  Article
  • Scripps Research Institute Chemist Phil Baran Named MacArthur Fellow  News Release
  • Scripps Research Team Wins Global Race to Achieve Landmark Synthesis of Perplexing Natural Product  Newsletter
  • Scripps Research Welcomes Stanford Club of San Diego to La Jolla Campus  Newsletter
  • TSRI Chemists’ Work Selected Among Most Significant in 2013  Newsletter
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Research

research overview

  • In the 20th century the art and science of complex natural product total synthesis defined the frontiers of organic chemistry. Throughout these decades fundamental insights into reactivity and selectivity principles were achieved by these numerous synthetic endeavors. The capability and power of organic synthesis has thus experienced a dramatic increase putting today’s synthetic chemists in the position to construct molecules of more or less any degree of structural complexity. The perception defining “art” in organic synthesis has therefore changed with time and in our opinion is described best by Hendrickson when he addressed the “ideal synthesis” as one which: “…creates a complex molecule… in a sequence of only construction reactions involving no intermediary refunctionalizations, and leading directly to the target, not only its skeleton but also its correctly placed functionality” (Hendrickson, J.B. J. Am. Chem. Soc. 1975, 97, 5784).

    This prescient statement truly encompasses and epitomizes the “economies” of synthesis design many years before ideas of atom, step, and redox-economy were formally galvanized. Now, in 2010, the field has reached an awe-inspiring level, with many proclaiming that synthesis has matured. But before one declares the science of synthesis an endeavor in engineering, one only needs to reflect on the inspiring ease with which Nature crafts large quantities of her most complex molecules (e.g. vancomycin and taxol). Total synthesis in this century must therefore be keenly aware of this ultimate challenge – to be able to provide large quantities of complex natural products with a minimum amount of labor and material expenses. The natural consequence of pursuing such a goal is to embrace the Hendrickson dictum (vide supra). Pursuing synthesis in such a way forces the practitioner into the role of an inventor. It naturally also leads to explorations into biology since multiple collaborations can be forged with ample materials.
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Teaching

advisees

  • graduate advising relationship

    • Barton, Lisa, Ph.D.  candidate, 2017 -
    • Bi, Cheng, Ph.D.  candidate, 2018 -
    • Gu, Jieyu, Ph.D.  candidate, 2019 -
    • Harwood, Stephen, Ph.D.  candidate, 2018 -
    • Kanda, Yuzuru, Ph.D.  candidate, 2016 -
    • Knouse, Kyle, Ph.D.  candidate, 2017 -
    • Mcclymont, Kyle, Ph.D.  candidate, 2016 -
    • Peters, David, Ph.D.  candidate, 2016 -
    • Reisberg, Solomon, Ph.D.  candidate, 2018 -
    • Stratton, Thomas Patrick, Ph.D.  candidate, 2017 -
    • Xu, Dongmin, Ph.D.  candidate, 2019 -
    • Chu, Hang, Ph.D.  candidate, 2015 - 2018
    • Edwards, Jacob, Ph.D.  candidate, 2015 - 2018
    • Farmer, Marcus, Ph.D.  candidate, 2014 - 2018
    • Merchant, Rohan, Ph.D.  candidate, 2015 - 2018
    • See, Yi Yang, Ph.D.  candidate, 2014 - 2018
    • deGruyter, Justine, Ph.D.  candidate, 2015 - 2018
    • Cernijenko, Artiom, Ph.D.  candidate, 2013 - 2017
    • Lo, Julian Castro, Ph.D.  candidate, 2013 - 2017
    • Yan, Ming, Ph.D.  candidate, 2013 - 2017
    • Dao, Hai Thanh, Ph.D.  candidate, 2012 - 2016
    • Martinez, Luis Ruben, Ph.D.  candidate, 2013 - 2016
    • Villaume, Matthew, Ph.B.  candidate, 2013 - 2016
    • Gianatassio, Ryan, Ph.D.  candidate, 2012 - 2015
    • Michaudel, Quentin, Ph.D.  candidate, 2011 - 2015
    • Rosen, Brandon, Ph.D.  candidate, 2012 - 2015
    • Wilde, Nathan, Ph.D.  candidate, 2012 - 2015
    • Cherney, Emily, Ph.D.  candidate, 2010 - 2014
    • Foo, Klement, Ph.D.  candidate, 2010 - 2014
    • Holte, Dane, Ph.D.  candidate, 2010 - 2014
    • McKerrall, Steven, Ph.D.  candidate, 2011 - 2014
    • Gutekunst, Will Ryan, Ph.D.  candidate, 2009 - 2013
    • Renata, Hans, Ph.D.  candidate, 2009 - 2013
    • Ishihara, Yoshihiro, Ph.D.  candidate, 2008 - 2012
    • Voica, Ana-Florina, Ph.D.  candidate, 2008 - 2012
    • Krawczuk, Paul J, Ph.D.  candidate, 2006 - 2011
    • Lockner, Jonathan, Ph.D.  candidate, 2007 - 2011
    • Seiple, Ian, Ph.D.  candidate, 2007 - 2011
    • Shi, Cindy Jun, Ph.D.  candidate, 2007 - 2011
    • Baran, Phil (Faculty Member) advising OMalley, Dan 2009 - 2010
    • Lin, David Wei, Ph.D.  candidate, 2004 - 2010
    • Newhouse, Timothy, Ph.D.  candidate, 2007 - 2010
    • Burns, Noah Z, Ph.D.  candidate, 2005 - 2009
    • Maimone, Thomas, Ph.D.  candidate, 2006 - 2009
    • DeMartino, Michael, Ph.D.  candidate, 2004 - 2008
    • Guerrero, Carlos, Ph.D.  candidate, 2004 - 2008
    • Hafensteiner, Benjamin, Ph.D.  candidate, 2004 - 2008
    • O'Malley, Dan, Ph.D.  candidate, 2004 - 2008
    • Richter, Jeremy, Ph.D.  candidate, 2004 - 2008
    • Shenvi, Ryan, Ph.D.  candidate, 2004 - 2008
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Background

education and training

  • Ph.D. in Chemistry, Scripps Research 1997 - 2001
  • B.S. in Chemistry, New York University , with Honors in Chemistry, with Dr. D. I. Schuster 1995 - 1997

awards and honors

  • Blavatnik National Award Winner, conferred by The Blavatnik Family Foundation, 2016
  • Mukaiyama Award, conferred by The Society of Synthetic Organic Chemistry, Japan, 2014
  • Synthetic Organic Chemistry Award, conferred by Royal Society of Chemistry, 2013
  • Fellow of the American Academy of Arts and Sciences, conferred by American Academy of Arts & Sciences, 2012
  • MacArthur Fellow, conferred by MacArthur Foundation, 2013 - 2017
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Contact

full name

  • Phil S. Baran

geographic location

  • Scripps California 
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Identity

ORCID iD

  • ORCID iD http://orcid.org/0000-0001-9193-9053

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