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An oxazolo[3,2-b]indazole route to 1-H-indazolones
An oxetane-based polyketide surrogate To probe substrate binding in a polyketide synthase
An oxidation domain in the blmiii non-ribosomal peptide synthetase probably catalyzing thiazole formation in the biosynthesis of the anti-tumor drug bleomycin in streptomyces verticillus atcc15003
An RNA binding site in a tRNA synthetase with a reduced set of amino acids
An RNA biosensor for imaging the first round of translation from single cells to living animals
An RNA conformational switch regulates pre-18S rRNA cleavage
An RNA targeted to the HIV-1 LTR promoter modulates indiscriminate off-target gene activation
An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation
An RNAi-based genetic screen for oxidative stress resistance reveals retinol saturase as a mediator of stress resistance
An RORγt oral inhibitor modulates IL-17 responses in peripheral blood and intestinal mucosa of Crohn's disease patients
An S(N)Ar approach to sterically hindered ortho-alkoxybenzaldehydes for the synthesis of olefin metathesis catalysts
An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence
An SMC-like protein binds and regulates Caenorhabditis elegans condensins
An ultra-high throughput cell-based screen for wee1 degradation inhibitors
An ultra-high-throughput screen for catalytic inhibitors of serine/threonine protein phosphatases types 1 and 5 (PP1C and PP5C)
An ultrastructural-study of dynorphin-immunoreactive nerve-fibers and terminals in the celiac-superior mesenteric ganglion of the guinea-pig
An unbiased analysis method to quantify mRNA localization reveals its correlation with cell motility
An unbiased high-throughput drug screen reveals a potential therapeutic vulnerability in the most lethal molecular subtype of pancreatic cancer
An Under-Appreciated Source of Reproducibility Issues in Cross-Coupling: Solid-State Decomposition of Primary Sodium Alkoxides in Air
An unexpected access to 5-epi-cyclophellitol: a new cyclitol member
An unexpected chelation-controlled Yb(OTf)(3)-catalyzed aminolysis and azidolysis of cyclitol epoxides
An unexpected effect of polyethylene glycol on the specificity of monoclonal anti-B
An unexpected example of protein-templated click chemistry
An unexpected N-heterocyclic carbene-catalyzed annulation of enals and nitroso compounds
An unexpected outcome of surface engineering an integral membrane protein: Improved crystallization of cytochrome ba(3) from thermus thermophilus
An unexpected switch in the modulation of AI-2-based quorum sensing discovered through synthetic 4,5-dihydroxy-2,3-pentanedione analogues
An unexpected twist in viral capsid maturation
An unexpectedly efficient catalytic antibody operating by ping-pong and induced fit mechanisms
An unnatural biopolymer
An unusual case of pseudo-merohedral twinning in orthorhombic crystals of Dicer