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  • An oxazolo[3,2-b]indazole route to 1-H-indazolones
  • An oxetane-based polyketide surrogate To probe substrate binding in a polyketide synthase
  • An oxidation domain in the blmiii non-ribosomal peptide synthetase probably catalyzing thiazole formation in the biosynthesis of the anti-tumor drug bleomycin in streptomyces verticillus atcc15003
  • An RNA binding site in a tRNA synthetase with a reduced set of amino acids
  • An RNA biosensor for imaging the first round of translation from single cells to living animals
  • An RNA conformational switch regulates pre-18S rRNA cleavage
  • An RNA targeted to the HIV-1 LTR promoter modulates indiscriminate off-target gene activation
  • An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation
  • An RNAi-based genetic screen for oxidative stress resistance reveals retinol saturase as a mediator of stress resistance
  • An RORγt oral inhibitor modulates IL-17 responses in peripheral blood and intestinal mucosa of Crohn's disease patients
  • An S(N)Ar approach to sterically hindered ortho-alkoxybenzaldehydes for the synthesis of olefin metathesis catalysts
  • An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence
  • An SMC-like protein binds and regulates Caenorhabditis elegans condensins
  • An ultra-high throughput cell-based screen for wee1 degradation inhibitors
  • An ultra-high-throughput screen for catalytic inhibitors of serine/threonine protein phosphatases types 1 and 5 (PP1C and PP5C)
  • An ultrastructural-study of dynorphin-immunoreactive nerve-fibers and terminals in the celiac-superior mesenteric ganglion of the guinea-pig
  • An unbiased analysis method to quantify mRNA localization reveals its correlation with cell motility
  • An unbiased high-throughput drug screen reveals a potential therapeutic vulnerability in the most lethal molecular subtype of pancreatic cancer
  • An Under-Appreciated Source of Reproducibility Issues in Cross-Coupling: Solid-State Decomposition of Primary Sodium Alkoxides in Air
  • An unexpected access to 5-epi-cyclophellitol: a new cyclitol member
  • An unexpected chelation-controlled Yb(OTf)(3)-catalyzed aminolysis and azidolysis of cyclitol epoxides
  • An unexpected effect of polyethylene glycol on the specificity of monoclonal anti-B
  • An unexpected example of protein-templated click chemistry
  • An unexpected N-heterocyclic carbene-catalyzed annulation of enals and nitroso compounds
  • An unexpected outcome of surface engineering an integral membrane protein: Improved crystallization of cytochrome ba(3) from thermus thermophilus
  • An unexpected switch in the modulation of AI-2-based quorum sensing discovered through synthetic 4,5-dihydroxy-2,3-pentanedione analogues
  • An unexpected twist in viral capsid maturation
  • An unexpectedly efficient catalytic antibody operating by ping-pong and induced fit mechanisms
  • An unnatural biopolymer
  • An unusual case of pseudo-merohedral twinning in orthorhombic crystals of Dicer
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