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An ion channel essential for sensing chemical damage
An ion selectivity filter in the extracellular domain of Cys-loop receptors reveals determinants for ion conductance
An iontophoretic survey of opioid peptide actions in the rat limbic system - in search of opiate epileptogenic mechanisms
An IRF-3-, IRF-5-, and IRF-7-independent pathway of dengue viral resistance utilizes IRF-1 to stimulate type I and II interferon responses
An Irreversible Inhibitor to Probe the Role of Streptococcus pyogenes Cysteine Protease SpeB in Evasion of Host Complement Defenses
An isogenic human ESC platform for functional evaluation of genome-wide-association-study-identified diabetes genes and drug discovery
An isothermal system that couples ligand-dependent catalysis to ligand-independent exponential amplification
An isotope labeling strategy for quantifying the degree of phosphorylation at multiple sites in proteins
An isotopically tagged azobenzene-based cleavable linker for quantitative proteomics
An L-RNA aptamer that binds and inhibits RNase
An LPA species (18:1 LPA) plays key roles in the self-amplification of spinal LPA production in the peripheral neuropathic pain model
An lrp8 variant is associated with familial and premature coronary artery disease and myocardial infarction
An LXR-cholesterol axis creates a metabolic co-dependency for brain cancers
An MPER antibody neutralizes HIV-1 using germline features shared among donors
An mrna-rrna base-pairing mechanism for translation initiation in eukaryotes
An Mtb-human protein-protein interaction map identifies a switch between host antiviral and antibacterial responses
An Mtr4/ZFC3H1 complex facilitates turnover of unstable nuclear RNAs to prevent their cytoplasmic transport and global translational repression
An MXD1-derived repressor peptide identifies noncoding mediators of MYC-driven cell proliferation
An NIR-guided aggregative and self-immolative nanosystem for efficient cancer targeting and combination anticancer therapy
An NMR method for assigning relative stereochemistry to beta-hydroxy ketones deriving from aldol reactions of methyl ketones
An NMR perspective on enzyme dynamics
An NMR study of the rates of single-molecule exchange in a cylindrical host capsule
An o-glycoside of sialic acid derivative that inhibits both hemagglutinin and sialidase activities of influenza viruses
An o-nitrobenzyl scaffold for peptide ligation: synthesis and applications
An observational method for quantifying the behavioral-effects of dopamine agonists - contrasting effects of d-amphetamine and apomorphine
An olefin metathesis based strategy for the construction of the JKL, OPQ, and UVW ring systems of maitotoxin
An online resource for GPCR structure determination and analysis
An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution
An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7
An open letter to the metabolomics community: looking forward to a future of integrative plant biology