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An adaptor from translational to transcriptional control enables predictable assembly of complex regulation
An additional spirocyclization for duocarmycin SA
An adjustable-threshold algorithm for the identification of objects in three-dimensional images
An Advance in Prescription Opioid Vaccines: Overdose Mortality Reduction and Extraordinary Alteration of Drug Half-Life
An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10
An age-dependent interaction with leptin unmasks ghrelin's bone-protective effects
An aged immune system drives senescence and ageing of solid organs
An agonist antibody prefers relapsed AML for induction of cells that kill each other
An agonist antibody that blocks autoimmunity by inducing anti-inflammatory macrophages
An agrin minigene rescues dystrophic symptoms in a mouse model for congenital muscular dystrophy
An ahemolytic pneumolysin of Streptococcus pneumoniae manipulates human innate and CD4⁺ T-cell responses and reduces resistance to colonization in mice in a serotype-independent manner
An Akt3 splice variant lacking the serine 472 phosphorylation site promotes apoptosis and suppresses mammary tumorigenesis
An alerting structure: human orexin receptor 1
An algorithm for generating small RNAs capable of epigenetically modulating transcriptional gene silencing and activation in human cells
An alkoxide-directed alkyne-allene cross-coupling for stereoselective synthesis of 1,4-dienes
An alkoxide-directed carbometalation of internal alkynes
An alkoxide-directed intermolecular 2+2+1 annulation: A three-component coupling reaction for the synthesis of tetrasubstituted alpha,beta,-unsaturated gamma-lactams
An alkynylboronic ester annulation: Development of synthetic methods for application to diversity-oriented organic synthesis
An all-purpose antimalarial drug target
An allospecific murine T helper clone which can help both T and B cell responses in vitro and in vivo
An allosteric ca2+ binding site on the beta 3 integrins that regulates the dissociation rate for rgd ligands
An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1
An allosteric network in spastin couples multiple activities required for microtubule severing
An allosteric peptide inhibitor of HIF-1α regulates hypoxia-induced retinal neovascularization
An alpha beta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex
An alpha-2-macroglobulinlike activity in the blood of chelicerate and mandibulate arthropods
An altered zinc-binding site confers resistance to a covalent inactivator of New Delhi metallo-beta-lactamase-1 (NDM-1) discovered by high-throughput screening
An alternate binding site for PPARγ ligands
An alternate conformation of HCV E2 neutralizing face as an additional vaccine target
An alternative and convenient strategy for generation of substantial quantities of singly 5-32P-end-labeled double-stranded DNA for binding-studies - development of a protocol for examination of functional features of (+)-CC-1065 and the duocarmycins that contribute to their sequence-selective DNA alkylation properties