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Cytochrome P-450 CYP2C19

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  • CYP2C19 participates in tolbutamide hydroxylation by human liver microsomes  Academic Article
  • Diazepam metabolism by cDNA-Expressed human 2C p450s: identification of P4502C18 and P4502C19 as low K(M) diazepam N-demethylases  Academic Article
  • Effects of clopidogrel on the pharmacokinetics of sibutramine and its active metabolites  Academic Article
  • Emerging genomic applications in coronary artery disease  Academic Article
  • Identification of amino acid substitutions that confer a high affinity for sulfaphenazole binding and a high catalytic efficiency for warfarin metabolism to P450 2C19  Academic Article
  • Identification of human CYP2C19 residues that confer S-mephenytoin 4'-hydroxylation activity to CYP2C9  Academic Article
  • Impact of proton pump inhibitor therapy on the efficacy of clopidogrel in the CAPRIE and CREDO trials  Academic Article
  • Influence of genetic polymorphisms on the effect of high-and standard-dose clopidogrel after percutaneous coronary intervention the gift (genotype information and functional testing) study  Academic Article
  • Pharmacogenetics-based population pharmacokinetic analysis of etravirine in HIV-1 infected individuals  Academic Article
  • Pilot study of the antiplatelet effect of increased clopidogrel maintenance dosing and its relationship to cyp2c19 genotype in patients with high on-treatment reactivity  Academic Article
  • Structural characterization of human cytochrome P450 2C19: active site differences between P450s 2C8, 2C9, and 2C19  Academic Article
  • Sulfaphenazole derivatives as tools for comparing cytochrome P450 2C5 and human cytochromes P450 2Cs: identification of a new high affinity substrate common to those enzymes  Academic Article
  • Targeted antipeptide antibodies to cytochrome P450 2C18 based on epitope mapping of an inhibitory monoclonal antibody to P450 2C51  Academic Article
  • The relationship between cyp2c19 polymorphisms and ischaemic and bleeding outcomes in stable outpatients: The charisma genetics study  Academic Article

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