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Chemistry Techniques, Synthetic

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  • 4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency  Academic Article
  • A practical sulfenylation of 2,5-diketopiperazines  Academic Article
  • Activation of remote meta-C-H bonds assisted by an end-on template  Academic Article
  • An approach to mimicking the sesquiterpene cyclase phase by nickel-promoted diene/alkyne cooligomerization  Academic Article
  • Approaches to the chemical synthesis of the chlorosulfolipids  Academic Article
  • Axinellamines as broad-spectrum antibacterial agents: scalable synthesis and biology  Academic Article
  • Caged [(18)F]FDG glycosylamines for imaging acidic tumor microenvironments using positron emission tomography  Academic Article
  • Chemoenzymatic synthesis of cholesteryl-6-O-tetradecanoyl-alpha-D-glucopyranoside: a product of host cholesterol efflux promoted by Helicobacter pylori  Academic Article
  • Constructing molecular complexity and diversity: Total synthesis of natural products of biological and medicinal importance  Academic Article
  • Data-driven synthesis of proteolysis-resistant peptide hormones  Academic Article
  • De novo synthesis of L-colitose and L-rhodinose building blocks  Academic Article
  • Design and synthesis of 1,2,3-triazole-containing N-acyl zanamivir analogs as potent neuraminidase inhibitors  Academic Article
  • Design, synthesis and evaluation of 2,5-diketopiperazines as inhibitors of the MDM2-p53 interaction  Academic Article
  • Design, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactions  Academic Article
  • Discovery and optimization of a series of pyrimidine-based phosphodiesterase 10A (PDE10A) inhibitors through fragment screening, structure-based design, and parallel synthesis  Academic Article
  • Dosage delivery of sensitive reagents enables glove-box-free synthesis  Academic Article
  • Dynamic covalent side-chain cross-links via intermolecular oxime or hydrazone formation from bifunctional peptides and simple organic linkers  Academic Article
  • Editorial overview: Synthetic biomolecules  Academic Article
  • Efficient and stereoselective synthesis of alpha(2 -> 9) oligosialic acids: From monomers to dodecamers  Academic Article
  • Enantioselective Heck arylations of acyclic alkenyl alcohols using a redox-relay strategy  Academic Article
  • Enantioselective total syntheses of (-)-palau'amine, (-)-axinellamines, and (-)-massadines  Academic Article
  • Functionalized olefin cross-coupling to construct carbon-carbon bonds  Academic Article
  • Gas extrusion in natural products total synthesis  Academic Article
  • Glycocalyx scaffolding with synthetic nanoscale glycomaterials  Academic Article
  • Improved syntheses of phosphine ligands by direct coupling of diarylbromophosphine with organometallic reagents  Academic Article
  • Improving the pharmacokinetic and CYP inhibition profiles of azaxanthene-based glucocorticoid receptor modulators-identification of (S)-5-(2-(9-fluoro-2-(4-(2-hydroxypropan-2-yl)phenyl)-5H-chromeno[2,3-b]pyridin-5-yl)-2-methylpropanamido)-N-(tetrahydro-2H-pyran-4-yl)-1,3,4-thiadiazole-2-carboxamide (BMS-341)  Academic Article
  • Lactonization as a general route to β-C(sp 3)-H functionalization 
  • Ligand-enabled β-C-H arylation of α-amino acids using a simple and practical auxiliary  Academic Article
  • Natural product synthesis at the interface of chemistry and biology  Academic Article
  • Nineteen-step total synthesis of (+)-phorbol  Academic Article
  • Novel analogues of (R)-5-(methylamino)-5,6-dihydro-4H-imidazo 4,5,1-ij quinolin-2(1H)-one (sumanirole) provide clues to dopamine D-2/D-3 receptor agonist selectivity  Academic Article
  • Organic chemistry: A cure for catalyst poisoning  Academic Article
  • Palladium-catalyzed dearomative syn-1,4-carboamination  Academic Article
  • Palladium-catalyzed dearomative syn-1,4-carboamination  Academic Article
  • Pd(ii)-catalyzed para-selective c-h arylation of monosubstituted arenes  Academic Article
  • Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif  Academic Article
  • Regioselective base-free intermolecular aminohydroxylations of hindered and functionalized alkenes  Academic Article
  • Scalable and sustainable electrochemical allylic C-H oxidation  Academic Article
  • Scalable, stereocontrolled total syntheses of (±)-axinellamines A and B  Academic Article
  • Sequential one-pot enzymatic synthesis of oligo-N-acetyllactosamine and its multi-sialylated extensions  Academic Article
  • Silver(I)-promoted conversion of thioamides to amidines: divergent synthesis of a key series of vancomycin aglycon residue 4 amidines that clarify binding behavior to model ligands  Academic Article
  • Site-specific immobilization of enzymes on magnetic nanoparticles and their use in organic synthesis  Academic Article
  • Stereoinversion of tertiary alcohols to tertiary-alkyl isonitriles and amines  Academic Article
  • Strain-release amination  Academic Article
  • Support of academic synthetic chemistry using separation technologies from the pharmaceutical industry  Academic Article
  • Sustainable practices in medicinal chemistry Part 2: Green by design  Academic Article
  • Switchable catalysis with a light-responsive cavitand  Academic Article
  • Synthesis and biological evaluation of QRSTUVWXYZA' domains of maitotoxin  Academic Article
  • Synthesis and biological evaluation of dimeric furanoid macroheterocycles: discovery of new anticancer agents  Academic Article
  • Synthesis and biological evaluation of manassantin analogues for hypoxia-inducible factor 1α inhibition  Academic Article
  • Synthesis and biological evaluation of urea derivatives as highly potent and selective rho kinase inhibitors  Academic Article
  • Synthesis and screening of stereochemically diverse combinatorial libraries of peptide tertiary amides  Academic Article
  • Synthesis of (+)-pancratistatins via catalytic desymmetrization of benzene  Academic Article
  • Synthesis of highly strained terpenes by non-stop tail-to-head polycyclization  Academic Article
  • Synthesis of highly strained terpenes by non-stop tail-to-head polycyclization  Academic Article
  • Synthesis of medicinally relevant terpenes: reducing the cost and time of drug discovery  Academic Article
  • Synthesis of oligomeric mannosides and their structure-binding relationship with concanavalin A  Academic Article
  • Synthesis/biological evaluation of hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain  Academic Article
  • Synthesis: A constructive debate  Academic Article
  • The synthesis and in vivo evaluation of F-18 PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH)  Academic Article
  • Total syntheses and initial evaluation of [?[C(-S)NH]Tpg(4)]vancomycin, [?[C(-NH)NH]Tpg(4)]vancomycin, [?[CH2NH]Tpg(4)]vancomycin, and their (4-Chlorobiphenyl)methyl derivatives: synergistic binding pocket and peripheral modifications for the glycopeptide antibiotics  Academic Article
  • Total syntheses of anominine and tubingensin a  Academic Article
  • Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens  Academic Article
  • Total synthesis of hyperforin  Academic Article

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