subject area of

• A role for rev-erb alpha ligands in the regulation of adipogenesis  Academic Article
• A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein  Academic Article
• Autophagy-regulated ROS from xanthine oxidase acts as an early effector for triggering late mitochondria-dependent apoptosis in cathepsin S-targeted tumor cells  Academic Article
• Beyond the ligand: extracellular and transcellular G protein-coupled receptor complexes in physiology and pharmacology  Academic Article
• Broad anti-tumor activity of a small molecule that selectively targets the Warburg effect and lipogenesis  Academic Article
• Cancer immunotherapy: Opportunities and challenges in the rapidly evolving clinical landscape  Academic Article
• Chemical approaches to stem cell biology and therapeutics  Academic Article
• Clinical applications of genome editing to HIV cure  Academic Article
• Combined targeting of costimulatory (OX40) and coinhibitory (CTLA-4) pathways elicits potent effector T cells capable of driving robust antitumor immunity  Academic Article
• Control of experimental spasticity by targeting the degradation of endocannabinoids using selective fatty acid amide hydrolase inhibitors  Academic Article
• Cystic fibrosis in an era of genomically guided therapy  Academic Article
• Design and discovery of N-(2-Methyl-5 '-morpholino-6 '-((tetrahydro-2H-pyran-4-yl)oxy)- 3,3 '-bipyridin -5-yl)-3-(trifluoromethyl)benzamide (RAF709): a potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers  Academic Article
• Designing a broad-spectrum integrative approach for cancer prevention and treatment  Academic Article
• Determining target engagement in living systems  Academic Article
• Discovery of novel drugs for promising targets  Academic Article
• Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition  Academic Article
• Endocannabinoid regulation of amyloid-induced neuroinflammation  Academic Article
• Glucokinase activators  Academic Article
• HIV latency and the noncoding RNA therapeutic landscape  Academic Article
• How ligands illuminate GPCR molecular pharmacology  Academic Article
• Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network  Academic Article
• Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models  Academic Article
• Inhibition of class i histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue  Academic Article
• Kinetic analysis of membrane potential dye response to NaV1.7 channel activation identifies antagonists with pharmacological selectivity against NaV1.5  Academic Article
• Lysophospholipid receptors in drug discovery  Academic Article
• Mechanisms of drug resistance in kinases  Academic Article
• Musashi RNA-binding proteins as cancer drivers and novel therapeutic targets  Academic Article
• NF-κB-activating complex engaged in response to EGFR oncogene inhibition drives tumor cell survival and residual disease in lung cancer  Academic Article
• Necessity of lysophosphatidic acid receptor 1 for development of arthritis  Academic Article
• New treatment options for hearing loss  Academic Article
• Not so pseudo anymore: pseudogenes as therapeutic targets  Academic Article
• Novel approaches for targeting the adenosine A2A receptor  Academic Article
• PI3K and STAT3: A new alliance  Academic Article
• Passenger deletions generate therapeutic vulnerabilities in cancer  Academic Article
• Patient-derived models of acquired resistance can identify effective drug combinations for cancer  Academic Article
• Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness  Academic Article
• Pyrrolidin-3-yl-N-methylbenzamides as potent histamine 3 receptor antagonists  Academic Article
• RNA structures as mediators of neurological diseases and as drug targets  Academic Article
• Rational design of chemical genetic probes of RNA function and lead therapeutics targeting repeating transcripts  Academic Article
• Rational design, biophysical and biological characterization of site-specific antibody-tubulysin conjugates with improved stability, efficacy and pharmacokinetics  Academic Article
• Restricted cell surface expression of receptor tyrosine kinase ROR1 in pediatric B-lineage acute lymphoblastic leukemia suggests targetability with therapeutic monoclonal antibodies  Academic Article
• Rho kinase inhibitors: a patent review (2012-2013)  Academic Article
• Role of corticotropin-releasing factor in drug addiction potential for pharmacological intervention  Academic Article
• Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditions  Academic Article
• Small molecule targeting of a microRNA associated with hepatocellular carcinoma  Academic Article
• Structural properties of non-traditional drug targets present new challenges for virtual screening  Academic Article
• Synthesis and structure-activity relationship of 4-quinolone-3-carboxylic acid based inhibitors of glycogen synthase kinase-3 beta  Academic Article
• Targeting cancer metabolism to develop human lactate dehydrogenase (hLDH)5 inhibitors  Academic Article
• Targeting cathepsin S induces tumor cell autophagy via the EGFR-ERK signaling pathway  Academic Article
• Targeting lactate metabolism for cancer therapeutics  Academic Article
• Targeting malignant B cells with an immunotoxin against ROR1  Academic Article
• Targeting renal cell carcinoma with a HIF-2 antagonist  Academic Article
• Targeting tumor cell invasion and dissemination in vivo by an aptamer that inhibits urokinase-type plasminogen activator through a novel multifunctional mechanism  Academic Article
• Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases  Academic Article
• The GPCR Network: a large-scale collaboration to determine human GPCR structure and function  Academic Article
• The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs  Academic Article
• The hybrid pyrroloisoindolone-dehydropyrrolizine alkaloid (-)-chlorizidine A targets proteins within the glycolytic pathway  Academic Article
• The tumor microenvironment: A target for combination therapy of breast cancer  Academic Article
• Therapeutic targeting of casein kinase 1δ in breast cancer  Academic Article
• Tissue factor-activated coagulation cascade in the tumor microenvironment is critical for tumor progression and an effective target for therapy  Academic Article
• What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?  Academic Article