subject area of
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- Beyond the ligand: extracellular and transcellular G protein-coupled receptor complexes in physiology and pharmacology Academic Article
- Broad anti-tumor activity of a small molecule that selectively targets the Warburg effect and lipogenesis Academic Article
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- Clinical applications of genome editing to HIV cure Academic Article
- Combined targeting of costimulatory (OX40) and coinhibitory (CTLA-4) pathways elicits potent effector T cells capable of driving robust antitumor immunity Academic Article
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- Design and discovery of N-(2-Methyl-5 '-morpholino-6 '-((tetrahydro-2H-pyran-4-yl)oxy)- 3,3 '-bipyridin -5-yl)-3-(trifluoromethyl)benzamide (RAF709): a potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers Academic Article
- Designing a broad-spectrum integrative approach for cancer prevention and treatment Academic Article
- Determining target engagement in living systems Academic Article
- Discovery of novel drugs for promising targets Academic Article
- Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition Academic Article
- Endocannabinoid regulation of amyloid-induced neuroinflammation Academic Article
- Glucokinase activators Academic Article
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- How ligands illuminate GPCR molecular pharmacology Academic Article
- Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network Academic Article
- Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models Academic Article
- Inhibition of class i histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue Academic Article
- Kinetic analysis of membrane potential dye response to NaV1.7 channel activation identifies antagonists with pharmacological selectivity against NaV1.5 Academic Article
- Lysophospholipid receptors in drug discovery Academic Article
- Mechanisms of drug resistance in kinases Academic Article
- Musashi RNA-binding proteins as cancer drivers and novel therapeutic targets Academic Article
- NF-κB-activating complex engaged in response to EGFR oncogene inhibition drives tumor cell survival and residual disease in lung cancer Academic Article
- Necessity of lysophosphatidic acid receptor 1 for development of arthritis Academic Article
- New treatment options for hearing loss Academic Article
- Not so pseudo anymore: pseudogenes as therapeutic targets Academic Article
- Novel approaches for targeting the adenosine A2A receptor Academic Article
- PI3K and STAT3: A new alliance Academic Article
- Passenger deletions generate therapeutic vulnerabilities in cancer Academic Article
- Patient-derived models of acquired resistance can identify effective drug combinations for cancer Academic Article
- Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness Academic Article
- Pyrrolidin-3-yl-N-methylbenzamides as potent histamine 3 receptor antagonists Academic Article
- RNA structures as mediators of neurological diseases and as drug targets Academic Article
- Rational design of chemical genetic probes of RNA function and lead therapeutics targeting repeating transcripts Academic Article
- Rational design, biophysical and biological characterization of site-specific antibody-tubulysin conjugates with improved stability, efficacy and pharmacokinetics Academic Article
- Restricted cell surface expression of receptor tyrosine kinase ROR1 in pediatric B-lineage acute lymphoblastic leukemia suggests targetability with therapeutic monoclonal antibodies Academic Article
- Rho kinase inhibitors: a patent review (2012-2013) Academic Article
- Role of corticotropin-releasing factor in drug addiction potential for pharmacological intervention Academic Article
- Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditions Academic Article
- Small molecule targeting of a microRNA associated with hepatocellular carcinoma Academic Article
- Structural properties of non-traditional drug targets present new challenges for virtual screening Academic Article
- Synthesis and structure-activity relationship of 4-quinolone-3-carboxylic acid based inhibitors of glycogen synthase kinase-3 beta Academic Article
- Targeting cancer metabolism to develop human lactate dehydrogenase (hLDH)5 inhibitors Academic Article
- Targeting cathepsin S induces tumor cell autophagy via the EGFR-ERK signaling pathway Academic Article
- Targeting lactate metabolism for cancer therapeutics Academic Article
- Targeting malignant B cells with an immunotoxin against ROR1 Academic Article
- Targeting renal cell carcinoma with a HIF-2 antagonist Academic Article
- Targeting tumor cell invasion and dissemination in vivo by an aptamer that inhibits urokinase-type plasminogen activator through a novel multifunctional mechanism Academic Article
- Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases Academic Article
- The GPCR Network: a large-scale collaboration to determine human GPCR structure and function Academic Article
- The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs Academic Article
- The hybrid pyrroloisoindolone-dehydropyrrolizine alkaloid (-)-chlorizidine A targets proteins within the glycolytic pathway Academic Article
- The tumor microenvironment: A target for combination therapy of breast cancer Academic Article
- Therapeutic targeting of casein kinase 1δ in breast cancer Academic Article
- Tissue factor-activated coagulation cascade in the tumor microenvironment is critical for tumor progression and an effective target for therapy Academic Article
- What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands? Academic Article