subject area of
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- 2-Bromopalmitate analogues as activity-based probes to explore palmitoyl acyltransferases Academic Article
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- 8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors Academic Article
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- A SNAP-tag fluorogenic probe mimicking the chromophore of the red fluorescent protein Kaede Academic Article
- A chemically stable fluorescent marker of the ureter Academic Article
- A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles Academic Article
- A chimeric hiv-1 envelope glycoprotein trimer with an embedded granulocyte-macrophage colony-stimulating factor (gm-csf) domain induces enhanced antibody and t cell responses Academic Article
- A complex of Protocadherin-19 and N-cadherin mediates a novel mechanism of cell adhesion Academic Article
- A comprehensive approach to zinc-finger recombinase customization enables genomic targeting in human cells Academic Article
- A conserved motif in the itk ph-domain is required for phosphoinositide binding and tcr signaling but dispensable for adaptor protein interactions Academic Article
- A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins Academic Article
- A fluorogenic aryl fluorosulfate for intraorganellar transthyretin imaging in living cells and in Caenorhabditis elegans Academic Article
- A genetically encoded aza-Michael acceptor for covalent cross-linking of protein-receptor complexes Academic Article
- A genetically encoded fluorescent probe in mammalian cells Academic Article
- A global map of lipid-binding proteins and their ligandability in cells Academic Article
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- A high-throughput cell-based Gaussia luciferase reporter assay for identifying modulators of fibulin-3 secretion Academic Article
- A lentiviral vector allowing physiologically regulated membrane-anchored and secreted antibody expression depending on B-cell maturation status Academic Article
- A mammalian expression system for high throughput antibody screening Academic Article
- A molecular switch regulating transcriptional repression and activation of PPARγ Academic Article
- A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks Academic Article
- A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation Academic Article
- A novel dual expression platform for high throughput functional screening of phage libraries in product like format Academic Article
- A novel α2/α4 subtype-selective positive allosteric modulator of nicotinic acetylcholine receptors acting from the C-tail of an α subunit Academic Article
- A platform for functional assessment of large variant libraries in mammalian cells Academic Article
- A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding Academic Article
- A practical synthesis of zanamivir phosphonate congeners with potent anti-influenza activity Academic Article
- A proximity based general method for identification of ligand and receptor interactions in living cells Academic Article
- A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells Academic Article
- A reversible and highly selective inhibitor of the proteasomal ubiquitin receptor rpn13 is toxic to multiple myeloma cells Academic Article
- A shared structural solution for neutralizing ebolaviruses Academic Article
- A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors Academic Article
- A superfolding Spinach2 reveals the dynamic nature of trinucleotide repeat-containing RNA Academic Article
- A two-antibody pan-ebolavirus cocktail confers broad therapeutic protection in ferrets and nonhuman primates Academic Article
- A variable cytoplasmic domain segment is necessary for γ-protocadherin trafficking and tubulation in the endosome/lysosome pathway Academic Article
- AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that suppresses cocaine-induced behavior Academic Article
- ABHD4-dependent developmental anoikis safeguards the embryonic brain Academic Article
- AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs Academic Article
- ATF6 activation reduces the secretion and extracellular aggregation of destabilized variants of an amyloidogenic protein Academic Article
- ATM-dependent phosphorylation of MEF2D promotes neuronal survival after DNA damage Academic Article
- Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors Academic Article
- Accessory genes confer a high replication rate to virulent feline immunodeficiency virus Academic Article
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- Activation of rabbit tlr9 by different cpg-odn optimized for mouse and human tlr9 Academic Article
- Addition of N-terminal peptide sequences activates the oncogenic and signaling potentials of the catalytic subunit p110α of phosphoinositide-3-kinase Academic Article
- Adeno-associated virus enhances wild-type and oncolytic adenovirus spread Academic Article
- Affinity maturation of a potent family of HIV antibodies is primarily focused on accommodating or avoiding glycans Academic Article
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- Akt-mediated phosphorylation of argonaute 2 downregulates cleavage and upregulates translational repression of MicroRNA targets Academic Article
- An HIV-encoded antisense long noncoding RNA epigenetically regulates viral transcription Academic Article
- An accessory agonist binding site promotes activation of α4β2* nicotinic acetylcholine receptors Academic Article
- An agonist antibody that blocks autoimmunity by inducing anti-inflammatory macrophages Academic Article
- An allosteric peptide inhibitor of HIF-1α regulates hypoxia-induced retinal neovascularization Academic Article
- An immunosuppressive antibody-drug conjugate Academic Article
- An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging Academic Article
- An isotopically tagged azobenzene-based cleavable linker for quantitative proteomics Academic Article
- An online resource for GPCR structure determination and analysis Academic Article
- Analysis of microRNAs expressions in chondrosarcoma Academic Article
- Analyzing and tuning ribozyme activity by deep sequencing to modulate gene expression level in mammalian cells Academic Article
- Androgen receptor splice variants determine taxane sensitivity in prostate cancer Academic Article
- Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor Academic Article
- Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike Academic Article
- Antibody conjugation via one and two C-terminal selenocysteines Academic Article
- Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env Academic Article
- Antibody to gp41 MPER alters functional properties of HIV-1 Env without complete neutralization Academic Article
- Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation Academic Article
- Antiproliferation activity of a small molecule repressor of liver receptor homolog 1 Academic Article
- Approaching rational epitope vaccine design for hepatitis C virus with meta-server and multivalent scaffolding Academic Article
- Aqueous two-phase printing of cell-containing contractile collagen microgels Academic Article
- Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKK epsilon Academic Article
- Arenavirus reverse genetics for vaccine development Academic Article
- Auto-fatty acylation of transcription factor RFX3 regulates ciliogenesis Academic Article
- Autocrine signaling based selection of combinatorial antibodies that transdifferentiate human stem cells Academic Article
- Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss Academic Article
- BET bromodomain proteins function as master transcription elongation factors independent of CDK9 recruitment Academic Article
- Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics Academic Article
- Band-pass processing in a GPCR signaling pathway selects for NFAT transcription factor activation Academic Article
- Bead aggregation assays for the characterization of putative cell adhesion molecules Academic Article
- Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46 Academic Article
- Bimolecular fluorescence complementation: lighting-up tau-tau interaction in living cells Academic Article
- Binding of β4γ5 by adenosine A1 and A2A receptors determined by stable isotope labeling with amino acids in cell culture and mass spectrometry Academic Article
- Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells Academic Article
- Broad and potent neutralization of hiv-1 by a gp41-specific human antibody Academic Article
- Broad neutralization coverage of HIV by multiple highly potent antibodies Academic Article
- Broadly applicable methodology for the rapid and dosable small molecule-mediated regulation of transcription factors in human cells Academic Article
- Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers Academic Article
- Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans Academic Article
- C-H activation generates period-shortening molecules that target cryptochrome in the mammalian circadian clock Academic Article
- CD4-induced activation in a soluble HIV-1 Env trimer Academic Article
- CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts Academic Article
- CPSF30 and Wdr33 directly bind to AAUAAA in mammalian mRNA 3 ' processing Academic Article
- CRTC1/MAML2 gain-of-function interactions with MYC create a gene signature predictive of cancers with CREB-MYC involvement Academic Article
- Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2 Academic Article
- Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry Academic Article
- Cd1b tetramers bind alpha beta t cell receptors to identify a mycobacterial glycolipid-reactive t cell repertoire in humans Academic Article
- Cell painting with an engineered EPCR to augment the protein C system Academic Article
- Cell-penetrating peptide-mediated delivery of TALEN proteins via bioconjugation for genome engineering Academic Article
- Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide Academic Article
- Characterization of a selective inhibitor of the parkinson's disease kinase lrrk2 Academic Article
- Characterization of an HIV-targeted transcriptional gene-silencing RNA in primary cells Academic Article
- Characterizing the altered cellular proteome induced by the stress-independent activation of heat shock factor 1 Academic Article
- Chemical probes to directly profile palmitoleoylation of proteins Academic Article
- Chemical proteomic platform to identify citrullinated proteins Academic Article
- Chemotype-selective modes of action of κ-opioid receptor agonists Academic Article
- Chimeric TALE recombinases with programmable DNA sequence specificity Academic Article
- Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells Academic Article
- Chronic treatment with novel brain-penetrating selective NOP receptor agonist MT-7716 reduces alcohol drinking and seeking in the rat Academic Article
- Cleavage-independent HIV-1 Env trimers engineered as soluble native spike mimetics for vaccine design Academic Article
- Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer Academic Article
- Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation Academic Article
- Commensal bacteria make GPCR ligands that mimic human signalling molecules Academic Article
- Comparability analysis of protein therapeutics by bottom-up LC-MS with stable isotope-tagged reference standards Academic Article
- Comprehensive analysis of structure-activity relationships of a-ketoheterocycles as sn-1-diacylglycerol lipase a inhibitors Academic Article
- Compromised mutant EFEMP1 secretion associated with macular dystrophy remedied by proteostasis network alteration Academic Article
- Constructing de novo H2O2 signaling via induced protein proximity Academic Article
- Controlling mammalian gene expression by allosteric hepatitis delta virus ribozymes Academic Article
- Cross-editing by a tRNA synthetase allows vertebrates to abundantly express mischargeable tRNA without causing mistranslation Academic Article
- Cross-talk between receptor tyrosine kinase and tumor necrosis factor-α signaling networks regulates apoptosis but not proliferation Academic Article
- Cryptochromes mediate rhythmic repression of the glucocorticoid receptor Academic Article
- Crystal structure of a fully glycosylated HIV-1 gp120 core reveals a stabilizing role for the glycan at Asn262 Academic Article
- Crystal structure of the human 4-1BB/4-1BBL complex Academic Article
- Crystal structure of the human n-myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor Academic Article
- Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor Academic Article
- Cutting Edge: CD1a tetramers and dextramers identify human lipopeptide-specific T cells ex vivo Academic Article
- Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins Academic Article
- Cytotoxicity of quantum dots used for in vitro cellular labeling: role of QD surface ligand, delivery modality, cell type, and direct comparison to organic fluorophores Academic Article
- D-Ornithine coopts pyrrolysine biosynthesis to make and insert pyrroline-carboxy-lysine Academic Article
- D471G mutation in LCMV-NP affects its ability to self-associate and results in a dominant negative effect in viral RNA synthesis Academic Article
- DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cells Academic Article
- De novo-designed enzymes as small-molecule-regulated fluorescence imaging tags and fluorescent reporters Academic Article
- Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function Academic Article
- Delivery of proteases in aqueous two-phase systems enables direct purification of stem cell colonies from feeder cell co-cultures for differentiation into functional cardiomyocytes Academic Article
- Delta-9,11 modification of glucocorticoids dissociates nuclear factor-κB inhibitory efficacy from glucocorticoid response element-associated side effects Academic Article
- Design of potent and proteolytically stable oxyntomodulin analogs Academic Article
- Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus Academic Article
- Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-1,6-dione γ-secretase modulators Academic Article
- Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor Academic Article
- Development of a high-throughput screening-compatible cell-based functional assay to identify small molecule probes of the galanin 3 receptor (GalR3) Academic Article
- Development of an HTS-compatible assay for discovery of ROR alpha modulators using AlphaScreen (r) technology Academic Article
- Development of an HTS-compatible assay for the discovery of ASK1 signalosome inhibitors using alphascreen technology Academic Article
- Development of small-molecule cryptochrome stabilizer derivatives as modulators of the circadian clock Academic Article
- Dextran as a generally applicable multivalent scaffold for improving immunoglobulin-binding affinities of peptide and peptidomimetic ligands Academic Article
- Di-acidic motifs in the membrane-distal C termini modulate the transport of angiotensin II receptors from the endoplasmic reticulum to the cell surface Academic Article
- Differences in AMPA and kainate receptor interactomes facilitate identification of AMPA receptor auxiliary subunit GSG1L Academic Article
- Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits Academic Article
- Direct antibody access to the HIV-1 membrane-proximal external region positively correlates with neutralization sensitivity Academic Article
- Direct detection of biotinylated proteins by mass spectrometry Academic Article
- Direct expression and validation of phage-selected peptide variants in mammalian cells Academic Article
- Direct interaction between TKS proteins and the N-terminal proline-rich region (PPR) of NoxA1 mediates Nox1-dependent ROS generation Academic Article
- Direct screening for ribozyme activity in mammalian cells Academic Article
- Discovery and characterization of an endogenous CXCR4 antagonist Academic Article
- Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5) Academic Article
- Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system Academic Article
- Discovery of a novel class of negative allosteric modulator of the dopamine D-2 receptor through fragmentation of a bitopic ligand Academic Article
- Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKKε kinases Academic Article
- Dismissal of RNA polymerase II underlies a large ligand-induced enhancer decommissioning program Academic Article
- Dispersible oxygen microsensors map oxygen gradients in three-dimensional cell cultures Academic Article
- Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells Academic Article
- Dissociating quaternary structure regulates cell-signaling functions of a secreted human tRNA synthetase Academic Article
- Distinct TCR signaling pathways drive proliferation and cytokine production in T cells Academic Article
- Distinct roles for somatically and dendritically synthesized brain-derived neurotrophic factor in morphogenesis of dendritic spines Academic Article
- Drosophila TRPA1 isoforms detect UV light via photochemical production of H2O2 Academic Article
- EEPD1 rescues stressed replication forks and maintains genome stability by promoting end resection and homologous recombination repair Academic Article
- Early doors (Edo) mutant mouse reveals the importance of period 2 (PER2) PAS domain structure for circadian pacemaking Academic Article
- Ecto-Fc MS identifies ligand-receptor interactions through extracellular domain Fc fusion protein baits and shotgun proteomic analysis Academic Article
- Efficient interaction between arenavirus nucleoprotein (NP) and RNA-dependent RNA polymerase (L) is mediated by the virus nucleocapsid (NP-RNA) template Academic Article
- Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16 Academic Article
- Endogenous molecules stimulating n-acylethanolamine-hydrolyzing acid amidase (naaa) Academic Article
- Energy dependence of HCD on peptide fragmentation: stepped collisional energy finds the sweet spot Academic Article
- Energy stress regulates hippo-YAP signaling involving AMPK-mediated regulation of angiomotin-like 1 protein Academic Article
- Engineered cellular gene-replacement platform for selective and inducible proteolytic profiling Academic Article
- Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection Academic Article
- Engineering cell surfaces for orthogonal selectability Academic Article
- Enhanced aromatic sequons increase oligosaccharyltransferase glycosylation efficiency and glycan homogeneity Academic Article
- Enhanced human-type receptor binding by ferret-transmissible H5N1 with a K193T mutation Academic Article
- Enhanced recognition and neutralization of HIV-1 by antibody-derived CCR5-mimetic peptide variants Academic Article
- Enhancing MALDI time-of-flight mass spectrometer performance through spectrum averaging Academic Article
- Enhancing the specificity of recombinase-mediated genome engineering through dimer interface redesign Academic Article
- Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis Academic Article
- Euphohelioscopin A is a PKC activator capable of inducing macrophage differentiation Academic Article
- Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors Academic Article
- Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide Academic Article
- Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A₂A adenosine receptor Academic Article
- Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation Academic Article
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- Fbw7alpha and fbw7gamma collaborate to shuttle cyclin e1 into the nucleolus for multiubiquitylation Academic Article
- First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G Academic Article
- Fluorescence turn-on folding sensor to monitor proteome stress in live cells Academic Article
- Fluorophore-NanoLuc BRET reporters enable sensitive in vivo optical imaging and flow cytometry for monitoring tumorigenesis Academic Article
- Folding of fibroblast growth factor 1 is critical for its nonclassical release Academic Article
- Functional interaction of heat shock protein 90 and beclin 1 modulates toll-like receptor-mediated autophagy Academic Article
- Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist Academic Article
- Functional stability of unliganded envelope glycoprotein spikes among isolates of human immunodeficiency virus type 1 (HIV-1) Academic Article
- G protein-coupled receptor endocytosis confers uniformity in responses to chemically distinct ligands Academic Article
- GATA family members as inducers for cellular reprogramming to pluripotency Academic Article
- GNE-781, a highly advanced potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein, binding protein (CBP) Academic Article
- GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes Academic Article
- Gain-of-function ADCY5 mutations in familial dyskinesia with facial myokymia Academic Article
- Gating mechanisms of acid-sensing ion channels Academic Article
- Generation of soluble human tumor necrosis factor-alpha receptor 1-fc transgenic pig Academic Article
- Genetic incorporation of ε-N-2-hydroxyisobutyryl-lysine into recombinant histones Academic Article
- Genome engineering with custom recombinases Academic Article
- Girk channel modulation by assembly with allosterically regulated RGS proteins Academic Article
- Global landscape of HIV-human protein complexes Academic Article
- Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes Academic Article
- Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution Academic Article
- Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity Academic Article
- Glucosamine-6-sulfamate analogues of heparan sulfate as inhibitors of endosulfatases Academic Article
- Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies Academic Article
- Glycan sequence-dependent Nod2 activation investigated by using a chemically synthesized bacterial peptidoglycan fragment library Academic Article
- HIV-1 RNAs are not part of the argonaute 2 associated RNA interference pathway in macrophages Academic Article
- Heat shock protein 90AB1 and hyperthermia rescue infectivity of HIV with defective cores Academic Article
- Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanisms Academic Article
- Hepatitis C virus (HCV) induces formation of stress granules whose proteins regulate HCV RNA replication and virus assembly and egress Academic Article
- Hi-Fi transmission of periodic signals amid cell-to-cell variability Academic Article
- High throughput screening identifies novel, cell cycle-arresting small molecule enhancers of transient protein expression Academic Article
- High-Throughput Screening for Drugs That Inhibit Papain-Like Protease in SARS-CoV-2 Academic Article
- High-throughput assay and engineering of self-cleaving ribozymes by sequencing Academic Article
- High-throughput protein engineering improves the antigenicity and stability of soluble HIV-1 envelope glycoprotein SOSIP trimers Academic Article
- Highly complementary target RNAs promote release of guide RNAs from human Argonaute2 Academic Article
- Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates Academic Article
- Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock Academic Article
- Homologous recombination is a primary pathway to repair DNA double-strand breaks generated during DNA rereplication Academic Article
- Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis Academic Article
- Hsp90-cdc37 chaperone complex regulates ulk1-and atg13-mediated mitophagy Academic Article
- HtrA1 proteolysis of ApoE in vitro is allele selective Academic Article
- Human and host species transferrin receptor 1 use by north american arenaviruses Academic Article
- Human antibodies targeting the C-type lectin-like domain of the tumor endothelial cell marker clec14a regulate angiogenic properties in vitro Academic Article
- Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus Academic Article
- Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease Academic Article
- Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer Academic Article
- IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV Academic Article
- IFITM3 polymorphism rs12252-C restricts influenza A viruses Academic Article
- INPP4B suppresses prostate cancer cell invasion Academic Article
- IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation Academic Article
- Identification and mechanism of action of a novel small-molecule inhibitor of arenavirus multiplication Academic Article
- Identification of GABA(c) receptor protein homeostasis network components from three tandem mass spectrometry proteomics approaches Academic Article
- Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ Academic Article
- Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB Academic Article
- Identification of a peptide inhibitor of the RPM-1 · FSN-1 ubiquitin ligase complex Academic Article
- Identification of a selective ROR gamma ligand that suppresses T(H)17 cells and stimulates T regulatory cells Academic Article
- Identification of a tumor specific, active-site mutation in casein kinase 1α by chemical proteomics Academic Article
- Identification of common features in prototype broadly neutralizing antibodies to HIV envelope V2 apex to facilitate vaccine design Academic Article
- Identification of fibroblast growth factor receptor 3 (FGFR3) as a protein receptor for botulinum neurotoxin serotype A (BoNT/A) Academic Article
- Identification of microprotein-protein interactions via APEX tagging Academic Article
- Identification of novel targets for miR-29a using miRNA proteomics Academic Article
- Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP Academic Article
- Identification of small molecule activators of cryptochrome Academic Article
- Identification of the antiarrhythmic drugs amiodarone and lorcainide as potent H3 histamine receptor inverse agonists Academic Article
- Impact of substituents in tumor uptake and fluorescence imaging ability of near-infrared cyanine-like dyes Academic Article
- Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor Academic Article
- Impedance responses reveal β₂-adrenergic receptor signaling pluridimensionality and allow classification of ligands with distinct signaling profiles Academic Article
- In cellulo protein labelling with Ru-conjugate for luminescence imaging and bioorthogonal photocatalysis Academic Article
- In vitro and in vivo anticancer activity of a synthetic glycolipid as Toll-like receptor 4 (TLR4) activator Academic Article
- In vitro evolution of h5n1 avian influenza virus toward human-type receptor specificity Academic Article
- In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential Academic Article
- In vivo tagging and characterization of S-glutathionylated proteins by a chemoenzymatic method Academic Article
- Incomplete neutralization and deviation from sigmoidal neutralization curves for HIV broadly neutralizing monoclonal antibodies Academic Article
- Indications for a protective function of beta(2)-glycoprotein I in thrombotic thrombocytopenic purpura Academic Article
- Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules Academic Article
- Induction of p38δ expression plays an essential role in oncogenic ras-induced senescence Academic Article
- Infection of monkeys by simian-human immunodeficiency viruses with transmitted/founder clade C HIV-1 envelopes Academic Article
- Inflammatory signals enhance piezo2-mediated mechanosensitive currents Academic Article
- Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein Academic Article
- Inhibition of Delta-induced Notch signaling using fucose analogs Academic Article
- Inhibition of Dpp8/9 activates the Nlrp1b inflammasome Academic Article
- Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation Academic Article
- Inhibition of histone binding by supramolecular hosts Academic Article
- Inhibition of multiplication of the prototypic arenavirus LCMV by valproic acid Academic Article
- Innate immune defects in HIV permissive cell lines Academic Article
- Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins Academic Article
- Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II Academic Article
- Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin Academic Article
- Interferon-induced transmembrane protein 3 is a type II transmembrane protein Academic Article
- Intermolecular interaction between anchoring subunits specify subcellular targeting and function of RGS proteins in retina ON-bipolar neurons Academic Article
- L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity Academic Article
- LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates Academic Article
- LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway Academic Article
- Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins Academic Article
- Lead optimization and modulation of hERG activity in a series of aminooxazoline xanthene β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors Academic Article
- Lead optimization of antimalarial propafenone analogues Academic Article
- Levetiracetam inhibits oligomeric Aβ-induced glutamate release from human astrocytes Academic Article
- Ligand-binding dynamics rewire cellular signaling via estrogen receptor-alpha Academic Article
- Light control of cellular processes by using photocaged abscisic acid. Academic Article
- Like-acetylglucosaminyltransferase (large)-dependent modification of dystroglycan at thr-317/319 is required for laminin binding and arenavirus infection Academic Article
- Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells Academic Article
- Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape Academic Article
- Mammalian adaptation of influenza A(H7N9) virus is limited by a narrow genetic bottleneck Academic Article
- Manipulating JNK signaling with (-)-zuonin A Academic Article
- Marburg virus VP35 can both fully coat the backbone and cap the ends of dsRNA for interferon antagonism Academic Article
- Mechanism for selective synaptic wiring of rod photoreceptors into the retinal circuitry and its role in vision Academic Article
- Mechanism of activation of protein kinase JAK2 by the growth hormone receptor Academic Article
- Mechanistic pharmacokinetic-pharmacodynamic modeling of BACE1 inhibition in monkeys: development of a predictive model for amyloid precursor protein processing Academic Article
- Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids Academic Article
- Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone Academic Article
- Microfluidic interrogation and mathematical modeling of multi-regime calcium signaling dynamics Academic Article
- Microfluidic platform for chemotaxis in gradients formed by CXCL12 source-sink cells Academic Article
- Microrna-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function Academic Article
- Modification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release Academic Article
- Modulation of fluorescent protein chromophores to detect protein aggregation with turn-on fluorescence Academic Article
- Molecular determinants of selectivity and efficacy at the dopamine D3 receptor Academic Article
- Molecular dissection of the interaction between the AMPA receptor and cornichon homolog-3 Academic Article
- Molecular-interaction and signaling profiles of AM3677, a novel covalent agonist selective for the cannabinoid 1 receptor Academic Article
- Multiplex assessment of protein variant abundance by massively parallel sequencing Academic Article
- Multiplexed spectral signature detection for microfluidic color-coded bioparticle flow Academic Article
- Munc13-4 Is a Rab11-binding protein that regulates Rab11-positive vesicle trafficking and docking at the plasma membrane Academic Article
- Munc13-4 interacts with syntaxin 7 and regulates late endosomal maturation, endosomal signaling, and TLR9-initiated cellular responses Academic Article
- Murine antibody responses to cleaved soluble HIV-1 envelope trimers are highly restricted in specificity Academic Article
- Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis Academic Article
- N-cadherin regulates mammary tumor cell migration through Akt3 suppression Academic Article
- N332-directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function Academic Article
- NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells Academic Article
- NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component Academic Article
- New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases Academic Article
- Non-canonical Hedgehog/AMPK-mediated control of polyamine metabolism supports neuronal and medulloblastoma cell growth Academic Article
- Non-degradative ubiquitination of protein kinases Academic Article
- Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3 Academic Article
- Nucleotide binding to ARL2 in the TBCD∙ARL2∙β-tubulin complex drives conformational changes in β-tubulin Academic Article
- O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability Academic Article
- O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors Academic Article
- On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN) Academic Article
- Optochemical control of gene expression by photocaged guanine and riboswitches Academic Article
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