subject area of

• 2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport  Academic Article
• 2-Bromopalmitate analogues as activity-based probes to explore palmitoyl acyltransferases  Academic Article
• 24 hours in the life of HIV-1 in a T cell line  Academic Article
• 8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors  Academic Article
• A GTP affinity probe for proteomics highlights flexibility in purine nucleotide selectivity  Academic Article
• A HaloTag-based multicolor fluorogenic sensor visualizes and quantifies proteome stress in live cells using solvatochromic and molecular rotor-based fluorophores  Academic Article
• A SNAP-tag fluorogenic probe mimicking the chromophore of the red fluorescent protein Kaede  Academic Article
• A chemically stable fluorescent marker of the ureter  Academic Article
• A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles  Academic Article
• A chimeric hiv-1 envelope glycoprotein trimer with an embedded granulocyte-macrophage colony-stimulating factor (gm-csf) domain induces enhanced antibody and t cell responses  Academic Article
• A complex of Protocadherin-19 and N-cadherin mediates a novel mechanism of cell adhesion  Academic Article
• A comprehensive approach to zinc-finger recombinase customization enables genomic targeting in human cells  Academic Article
• A conserved motif in the itk ph-domain is required for phosphoinositide binding and tcr signaling but dispensable for adaptor protein interactions  Academic Article
• A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins  Academic Article
• A fluorogenic aryl fluorosulfate for intraorganellar transthyretin imaging in living cells and in Caenorhabditis elegans  Academic Article
• A genetically encoded aza-Michael acceptor for covalent cross-linking of protein-receptor complexes  Academic Article
• A genetically encoded fluorescent probe in mammalian cells  Academic Article
• A global map of lipid-binding proteins and their ligandability in cells  Academic Article
• A glycoengineered enzyme with multiple mannose-6-phosphates is internalized into diseased cells to restore its activity in lysosomes  Academic Article
• A high-throughput cell-based Gaussia luciferase reporter assay for identifying modulators of fibulin-3 secretion  Academic Article
• A lentiviral vector allowing physiologically regulated membrane-anchored and secreted antibody expression depending on B-cell maturation status  Academic Article
• A mammalian expression system for high throughput antibody screening  Academic Article
• A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks  Academic Article
• A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation  Academic Article
• A novel dual expression platform for high throughput functional screening of phage libraries in product like format  Academic Article
• A novel α2/α4 subtype-selective positive allosteric modulator of nicotinic acetylcholine receptors acting from the C-tail of an α subunit  Academic Article
• A platform for functional assessment of large variant libraries in mammalian cells  Academic Article
• A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding  Academic Article
• A practical synthesis of zanamivir phosphonate congeners with potent anti-influenza activity  Academic Article
• A proximity based general method for identification of ligand and receptor interactions in living cells  Academic Article
• A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells  Academic Article
• A reversible and highly selective inhibitor of the proteasomal ubiquitin receptor rpn13 is toxic to multiple myeloma cells  Academic Article
• A shared structural solution for neutralizing ebolaviruses  Academic Article
• A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors  Academic Article
• A superfolding Spinach2 reveals the dynamic nature of trinucleotide repeat-containing RNA  Academic Article
• A two-antibody pan-ebolavirus cocktail confers broad therapeutic protection in ferrets and nonhuman primates  Academic Article
• A variable cytoplasmic domain segment is necessary for γ-protocadherin trafficking and tubulation in the endosome/lysosome pathway  Academic Article
• AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that suppresses cocaine-induced behavior  Academic Article
• AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs  Academic Article
• ATF6 activation reduces the secretion and extracellular aggregation of destabilized variants of an amyloidogenic protein  Academic Article
• ATM-dependent phosphorylation of MEF2D promotes neuronal survival after DNA damage  Academic Article
• Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors  Academic Article
• Accessory genes confer a high replication rate to virulent feline immunodeficiency virus  Academic Article
• Activated protein c up-regulates procoagulant tissue factor activity on endothelial cells by shedding the tfpi kunitz 1 domain  Academic Article
• Activation of rabbit tlr9 by different cpg-odn optimized for mouse and human tlr9  Academic Article
• Addition of N-terminal peptide sequences activates the oncogenic and signaling potentials of the catalytic subunit p110α of phosphoinositide-3-kinase  Academic Article
• Adeno-associated virus enhances wild-type and oncolytic adenovirus spread  Academic Article
• Affinity maturation of a potent family of HIV antibodies is primarily focused on accommodating or avoiding glycans  Academic Article
• Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity  Academic Article
• Akt-mediated phosphorylation of argonaute 2 downregulates cleavage and upregulates translational repression of MicroRNA targets  Academic Article
• An HIV-encoded antisense long noncoding RNA epigenetically regulates viral transcription  Academic Article
• An accessory agonist binding site promotes activation of α4β2* nicotinic acetylcholine receptors  Academic Article
• An agonist antibody that blocks autoimmunity by inducing anti-inflammatory macrophages  Academic Article
• An immunosuppressive antibody-drug conjugate  Academic Article
• An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging  Academic Article
• An isotopically tagged azobenzene-based cleavable linker for quantitative proteomics  Academic Article
• An online resource for GPCR structure determination and analysis  Academic Article
• Analysis of microRNAs expressions in chondrosarcoma  Academic Article
• Analyzing and tuning ribozyme activity by deep sequencing to modulate gene expression level in mammalian cells  Academic Article
• Androgen receptor splice variants determine taxane sensitivity in prostate cancer  Academic Article
• Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor  Academic Article
• Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike  Academic Article
• Antibody conjugation via one and two C-terminal selenocysteines  Academic Article
• Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env  Academic Article
• Antibody to gp41 MPER alters functional properties of HIV-1 Env without complete neutralization  Academic Article
• Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation  Academic Article
• Antiproliferation activity of a small molecule repressor of liver receptor homolog 1  Academic Article
• Approaching rational epitope vaccine design for hepatitis C virus with meta-server and multivalent scaffolding  Academic Article
• Aqueous two-phase printing of cell-containing contractile collagen microgels  Academic Article
• Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKK epsilon  Academic Article
• Arenavirus reverse genetics for vaccine development  Academic Article
• Auto-fatty acylation of transcription factor RFX3 regulates ciliogenesis  Academic Article
• Autocrine signaling based selection of combinatorial antibodies that transdifferentiate human stem cells  Academic Article
• Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss  Academic Article
• BET bromodomain proteins function as master transcription elongation factors independent of CDK9 recruitment  Academic Article
• Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics  Academic Article
• Band-pass processing in a GPCR signaling pathway selects for NFAT transcription factor activation  Academic Article
• Bead aggregation assays for the characterization of putative cell adhesion molecules  Academic Article
• Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46  Academic Article
• Bimolecular fluorescence complementation: lighting-up tau-tau interaction in living cells  Academic Article
• Binding of β4γ5 by adenosine A1 and A2A receptors determined by stable isotope labeling with amino acids in cell culture and mass spectrometry  Academic Article
• Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells  Academic Article
• Broad and potent neutralization of hiv-1 by a gp41-specific human antibody  Academic Article
• Broad neutralization coverage of HIV by multiple highly potent antibodies  Academic Article
• Broadly applicable methodology for the rapid and dosable small molecule-mediated regulation of transcription factors in human cells  Academic Article
• Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers  Academic Article
• Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans  Academic Article
• C-H activation generates period-shortening molecules that target cryptochrome in the mammalian circadian clock  Academic Article
• CD4-induced activation in a soluble HIV-1 Env trimer  Academic Article
• CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts  Academic Article
• CPSF30 and Wdr33 directly bind to AAUAAA in mammalian mRNA 3 ' processing  Academic Article
• CRTC1/MAML2 gain-of-function interactions with MYC create a gene signature predictive of cancers with CREB-MYC involvement  Academic Article
• Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2  Academic Article
• Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry  Academic Article
• Cd1b tetramers bind alpha beta t cell receptors to identify a mycobacterial glycolipid-reactive t cell repertoire in humans  Academic Article
• Cell painting with an engineered EPCR to augment the protein C system  Academic Article
• Cell-penetrating peptide-mediated delivery of TALEN proteins via bioconjugation for genome engineering  Academic Article
• Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide  Academic Article
• Characterization of a selective inhibitor of the parkinson's disease kinase lrrk2  Academic Article
• Characterization of an HIV-targeted transcriptional gene-silencing RNA in primary cells  Academic Article
• Characterizing the altered cellular proteome induced by the stress-independent activation of heat shock factor 1  Academic Article
• Chemical probes to directly profile palmitoleoylation of proteins  Academic Article
• Chemical proteomic platform to identify citrullinated proteins  Academic Article
• Chemotype-selective modes of action of κ-opioid receptor agonists  Academic Article
• Chimeric TALE recombinases with programmable DNA sequence specificity  Academic Article
• Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells  Academic Article
• Chronic treatment with novel brain-penetrating selective NOP receptor agonist MT-7716 reduces alcohol drinking and seeking in the rat  Academic Article
• Cleavage-independent HIV-1 Env trimers engineered as soluble native spike mimetics for vaccine design  Academic Article
• Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer  Academic Article
• Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation  Academic Article
• Commensal bacteria make GPCR ligands that mimic human signalling molecules  Academic Article
• Comparability analysis of protein therapeutics by bottom-up LC-MS with stable isotope-tagged reference standards  Academic Article
• Comprehensive analysis of structure-activity relationships of a-ketoheterocycles as sn-1-diacylglycerol lipase a inhibitors  Academic Article
• Compromised mutant EFEMP1 secretion associated with macular dystrophy remedied by proteostasis network alteration  Academic Article
• Constructing de novo H2O2 signaling via induced protein proximity  Academic Article
• Controlling mammalian gene expression by allosteric hepatitis delta virus ribozymes  Academic Article
• Cross-talk between receptor tyrosine kinase and tumor necrosis factor-α signaling networks regulates apoptosis but not proliferation  Academic Article
• Cryptochromes mediate rhythmic repression of the glucocorticoid receptor  Academic Article
• Crystal structure of a fully glycosylated HIV-1 gp120 core reveals a stabilizing role for the glycan at Asn262  Academic Article
• Crystal structure of the human 4-1BB/4-1BBL complex  Academic Article
• Crystal structure of the human n-myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor  Academic Article
• Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor  Academic Article
• Cutting Edge: CD1a tetramers and dextramers identify human lipopeptide-specific T cells ex vivo  Academic Article
• Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins  Academic Article
• Cytotoxicity of quantum dots used for in vitro cellular labeling: role of QD surface ligand, delivery modality, cell type, and direct comparison to organic fluorophores  Academic Article
• D-Ornithine coopts pyrrolysine biosynthesis to make and insert pyrroline-carboxy-lysine  Academic Article
• D471G mutation in LCMV-NP affects its ability to self-associate and results in a dominant negative effect in viral RNA synthesis  Academic Article
• DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cells  Academic Article
• De novo-designed enzymes as small-molecule-regulated fluorescence imaging tags and fluorescent reporters  Academic Article
• Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function  Academic Article
• Delivery of proteases in aqueous two-phase systems enables direct purification of stem cell colonies from feeder cell co-cultures for differentiation into functional cardiomyocytes  Academic Article
• Delta-9,11 modification of glucocorticoids dissociates nuclear factor-κB inhibitory efficacy from glucocorticoid response element-associated side effects  Academic Article
• Design of potent and proteolytically stable oxyntomodulin analogs  Academic Article
• Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus  Academic Article
• Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-1,6-dione γ-secretase modulators  Academic Article
• Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor  Academic Article
• Development of a high-throughput screening-compatible cell-based functional assay to identify small molecule probes of the galanin 3 receptor (GalR3)  Academic Article
• Development of an HTS-compatible assay for discovery of ROR alpha modulators using AlphaScreen (r) technology  Academic Article
• Development of an HTS-compatible assay for the discovery of ASK1 signalosome inhibitors using alphascreen technology  Academic Article
• Development of small-molecule cryptochrome stabilizer derivatives as modulators of the circadian clock  Academic Article
• Dextran as a generally applicable multivalent scaffold for improving immunoglobulin-binding affinities of peptide and peptidomimetic ligands  Academic Article
• Di-acidic motifs in the membrane-distal C termini modulate the transport of angiotensin II receptors from the endoplasmic reticulum to the cell surface  Academic Article
• Differences in AMPA and kainate receptor interactomes facilitate identification of AMPA receptor auxiliary subunit GSG1L  Academic Article
• Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits  Academic Article
• Direct antibody access to the HIV-1 membrane-proximal external region positively correlates with neutralization sensitivity  Academic Article
• Direct detection of biotinylated proteins by mass spectrometry  Academic Article
• Direct expression and validation of phage-selected peptide variants in mammalian cells  Academic Article
• Direct interaction between TKS proteins and the N-terminal proline-rich region (PPR) of NoxA1 mediates Nox1-dependent ROS generation  Academic Article
• Direct screening for ribozyme activity in mammalian cells  Academic Article
• Discovery and characterization of an endogenous CXCR4 antagonist  Academic Article
• Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5)  Academic Article
• Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system  Academic Article
• Discovery of a novel class of negative allosteric modulator of the dopamine D-2 receptor through fragmentation of a bitopic ligand  Academic Article
• Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKKε kinases  Academic Article
• Dismissal of RNA polymerase II underlies a large ligand-induced enhancer decommissioning program  Academic Article
• Dispersible oxygen microsensors map oxygen gradients in three-dimensional cell cultures  Academic Article
• Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells  Academic Article
• Dissociating quaternary structure regulates cell-signaling functions of a secreted human tRNA synthetase  Academic Article
• Distinct TCR signaling pathways drive proliferation and cytokine production in T cells  Academic Article
• Distinct roles for somatically and dendritically synthesized brain-derived neurotrophic factor in morphogenesis of dendritic spines  Academic Article
• Drosophila TRPA1 isoforms detect UV light via photochemical production of H2O2  Academic Article
• EEPD1 rescues stressed replication forks and maintains genome stability by promoting end resection and homologous recombination repair  Academic Article
• Early doors (Edo) mutant mouse reveals the importance of period 2 (PER2) PAS domain structure for circadian pacemaking  Academic Article
• Ecto-Fc MS identifies ligand-receptor interactions through extracellular domain Fc fusion protein baits and shotgun proteomic analysis  Academic Article
• Efficient interaction between arenavirus nucleoprotein (NP) and RNA-dependent RNA polymerase (L) is mediated by the virus nucleocapsid (NP-RNA) template  Academic Article
• Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16  Academic Article
• Endogenous molecules stimulating n-acylethanolamine-hydrolyzing acid amidase (naaa)  Academic Article
• Energy dependence of HCD on peptide fragmentation: stepped collisional energy finds the sweet spot  Academic Article
• Energy stress regulates hippo-YAP signaling involving AMPK-mediated regulation of angiomotin-like 1 protein  Academic Article
• Engineered cellular gene-replacement platform for selective and inducible proteolytic profiling  Academic Article
• Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection  Academic Article
• Engineering cell surfaces for orthogonal selectability  Academic Article
• Enhanced aromatic sequons increase oligosaccharyltransferase glycosylation efficiency and glycan homogeneity  Academic Article
• Enhanced human-type receptor binding by ferret-transmissible H5N1 with a K193T mutation  Academic Article
• Enhanced recognition and neutralization of HIV-1 by antibody-derived CCR5-mimetic peptide variants  Academic Article
• Enhancing MALDI time-of-flight mass spectrometer performance through spectrum averaging  Academic Article
• Enhancing the specificity of recombinase-mediated genome engineering through dimer interface redesign  Academic Article
• Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis  Academic Article
• Euphohelioscopin A is a PKC activator capable of inducing macrophage differentiation  Academic Article
• Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors  Academic Article
• Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide  Academic Article
• Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A₂A adenosine receptor  Academic Article
• Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation  Academic Article
• Family-wide investigation of PDZ domain-mediated protein-protein interactions implicates β-catenin in maintaining the integrity of tight junctions  Academic Article
• Fbw7alpha and fbw7gamma collaborate to shuttle cyclin e1 into the nucleolus for multiubiquitylation  Academic Article
• First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G  Academic Article
• Fluorescence turn-on folding sensor to monitor proteome stress in live cells  Academic Article
• Fluorophore-NanoLuc BRET reporters enable sensitive in vivo optical imaging and flow cytometry for monitoring tumorigenesis  Academic Article
• Folding of fibroblast growth factor 1 is critical for its nonclassical release  Academic Article
• Functional interaction of heat shock protein 90 and beclin 1 modulates toll-like receptor-mediated autophagy  Academic Article
• Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist  Academic Article
• Functional stability of unliganded envelope glycoprotein spikes among isolates of human immunodeficiency virus type 1 (HIV-1)  Academic Article
• G protein-coupled receptor endocytosis confers uniformity in responses to chemically distinct ligands  Academic Article
• GATA family members as inducers for cellular reprogramming to pluripotency  Academic Article
• GNE-781, a highly advanced potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein, binding protein (CBP)  Academic Article
• GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes  Academic Article
• Gain-of-function ADCY5 mutations in familial dyskinesia with facial myokymia  Academic Article
• Gating mechanisms of acid-sensing ion channels  Academic Article
• Generation of soluble human tumor necrosis factor-alpha receptor 1-fc transgenic pig  Academic Article
• Genetic incorporation of ε-N-2-hydroxyisobutyryl-lysine into recombinant histones  Academic Article
• Genome engineering with custom recombinases  Academic Article
• Girk channel modulation by assembly with allosterically regulated RGS proteins  Academic Article
• Global landscape of HIV-human protein complexes  Academic Article
• Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes  Academic Article
• Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution  Academic Article
• Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity  Academic Article
• Glucosamine-6-sulfamate analogues of heparan sulfate as inhibitors of endosulfatases  Academic Article
• Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies  Academic Article
• Glycan sequence-dependent Nod2 activation investigated by using a chemically synthesized bacterial peptidoglycan fragment library  Academic Article
• HIV-1 RNAs are not part of the argonaute 2 associated RNA interference pathway in macrophages  Academic Article
• Heat shock protein 90AB1 and hyperthermia rescue infectivity of HIV with defective cores  Academic Article
• Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanisms  Academic Article
• Hepatitis C virus (HCV) induces formation of stress granules whose proteins regulate HCV RNA replication and virus assembly and egress  Academic Article
• Hi-Fi transmission of periodic signals amid cell-to-cell variability  Academic Article
• High throughput screening identifies novel, cell cycle-arresting small molecule enhancers of transient protein expression  Academic Article
• High-throughput assay and engineering of self-cleaving ribozymes by sequencing  Academic Article
• High-throughput protein engineering improves the antigenicity and stability of soluble HIV-1 envelope glycoprotein SOSIP trimers  Academic Article
• Highly complementary target RNAs promote release of guide RNAs from human Argonaute2  Academic Article
• Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates  Academic Article
• Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock  Academic Article
• Homologous recombination is a primary pathway to repair DNA double-strand breaks generated during DNA rereplication  Academic Article
• Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis  Academic Article
• Hsp90-cdc37 chaperone complex regulates ulk1-and atg13-mediated mitophagy  Academic Article
• HtrA1 proteolysis of ApoE in vitro is allele selective  Academic Article
• Human and host species transferrin receptor 1 use by north american arenaviruses  Academic Article
• Human antibodies targeting the C-type lectin-like domain of the tumor endothelial cell marker clec14a regulate angiogenic properties in vitro  Academic Article
• Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus  Academic Article
• Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease  Academic Article
• Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer  Academic Article
• IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV  Academic Article
• IFITM3 polymorphism rs12252-C restricts influenza A viruses  Academic Article
• INPP4B suppresses prostate cancer cell invasion  Academic Article
• IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation  Academic Article
• Identification and mechanism of action of a novel small-molecule inhibitor of arenavirus multiplication  Academic Article
• Identification of GABA(c) receptor protein homeostasis network components from three tandem mass spectrometry proteomics approaches  Academic Article
• Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ  Academic Article
• Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB  Academic Article
• Identification of a peptide inhibitor of the RPM-1 · FSN-1 ubiquitin ligase complex  Academic Article
• Identification of a selective ROR gamma ligand that suppresses T(H)17 cells and stimulates T regulatory cells  Academic Article
• Identification of a tumor specific, active-site mutation in casein kinase 1α by chemical proteomics  Academic Article
• Identification of common features in prototype broadly neutralizing antibodies to HIV envelope V2 apex to facilitate vaccine design  Academic Article
• Identification of fibroblast growth factor receptor 3 (FGFR3) as a protein receptor for botulinum neurotoxin serotype A (BoNT/A)  Academic Article
• Identification of microprotein-protein interactions via APEX tagging  Academic Article
• Identification of novel targets for miR-29a using miRNA proteomics  Academic Article
• Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP  Academic Article
• Identification of small molecule activators of cryptochrome  Academic Article
• Identification of the antiarrhythmic drugs amiodarone and lorcainide as potent H3 histamine receptor inverse agonists  Academic Article
• Impact of substituents in tumor uptake and fluorescence imaging ability of near-infrared cyanine-like dyes  Academic Article
• Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor  Academic Article
• Impedance responses reveal β₂-adrenergic receptor signaling pluridimensionality and allow classification of ligands with distinct signaling profiles  Academic Article
• In cellulo protein labelling with Ru-conjugate for luminescence imaging and bioorthogonal photocatalysis  Academic Article
• In vitro and in vivo anticancer activity of a synthetic glycolipid as Toll-like receptor 4 (TLR4) activator  Academic Article
• In vitro evolution of h5n1 avian influenza virus toward human-type receptor specificity  Academic Article
• In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential  Academic Article
• In vivo tagging and characterization of S-glutathionylated proteins by a chemoenzymatic method  Academic Article
• Incomplete neutralization and deviation from sigmoidal neutralization curves for HIV broadly neutralizing monoclonal antibodies  Academic Article
• Indications for a protective function of beta(2)-glycoprotein I in thrombotic thrombocytopenic purpura  Academic Article
• Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules  Academic Article
• Induction of p38δ expression plays an essential role in oncogenic ras-induced senescence  Academic Article
• Infection of monkeys by simian-human immunodeficiency viruses with transmitted/founder clade C HIV-1 envelopes  Academic Article
• Inflammatory signals enhance piezo2-mediated mechanosensitive currents  Academic Article
• Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein  Academic Article
• Inhibition of Delta-induced Notch signaling using fucose analogs  Academic Article
• Inhibition of Dpp8/9 activates the Nlrp1b inflammasome  Academic Article
• Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation  Academic Article
• Inhibition of histone binding by supramolecular hosts  Academic Article
• Inhibition of multiplication of the prototypic arenavirus LCMV by valproic acid  Academic Article
• Innate immune defects in HIV permissive cell lines  Academic Article
• Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins  Academic Article
• Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II  Academic Article
• Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin  Academic Article
• Interferon-induced transmembrane protein 3 is a type II transmembrane protein  Academic Article
• Intermolecular interaction between anchoring subunits specify subcellular targeting and function of RGS proteins in retina ON-bipolar neurons  Academic Article
• L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity  Academic Article
• LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates  Academic Article
• LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway  Academic Article
• Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins  Academic Article
• Lead optimization and modulation of hERG activity in a series of aminooxazoline xanthene β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors  Academic Article
• Lead optimization of antimalarial propafenone analogues  Academic Article
• Levetiracetam inhibits oligomeric Aβ-induced glutamate release from human astrocytes  Academic Article
• Ligand-binding dynamics rewire cellular signaling via estrogen receptor-alpha  Academic Article
• Light control of cellular processes by using photocaged abscisic acid.  Academic Article
• Like-acetylglucosaminyltransferase (large)-dependent modification of dystroglycan at thr-317/319 is required for laminin binding and arenavirus infection  Academic Article
• Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells  Academic Article
• Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape  Academic Article
• Mammalian adaptation of influenza A(H7N9) virus is limited by a narrow genetic bottleneck  Academic Article
• Manipulating JNK signaling with (-)-zuonin A  Academic Article
• Marburg virus VP35 can both fully coat the backbone and cap the ends of dsRNA for interferon antagonism  Academic Article
• Mechanism for selective synaptic wiring of rod photoreceptors into the retinal circuitry and its role in vision  Academic Article
• Mechanism of activation of protein kinase JAK2 by the growth hormone receptor  Academic Article
• Mechanistic pharmacokinetic-pharmacodynamic modeling of BACE1 inhibition in monkeys: development of a predictive model for amyloid precursor protein processing  Academic Article
• Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids  Academic Article
• Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone  Academic Article
• Microfluidic interrogation and mathematical modeling of multi-regime calcium signaling dynamics  Academic Article
• Microfluidic platform for chemotaxis in gradients formed by CXCL12 source-sink cells  Academic Article
• Microrna-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function  Academic Article
• Modification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release  Academic Article
• Modulation of fluorescent protein chromophores to detect protein aggregation with turn-on fluorescence  Academic Article
• Molecular determinants of selectivity and efficacy at the dopamine D3 receptor  Academic Article
• Molecular dissection of the interaction between the AMPA receptor and cornichon homolog-3  Academic Article
• Molecular-interaction and signaling profiles of AM3677, a novel covalent agonist selective for the cannabinoid 1 receptor  Academic Article
• Multiplex assessment of protein variant abundance by massively parallel sequencing  Academic Article
• Multiplexed spectral signature detection for microfluidic color-coded bioparticle flow  Academic Article
• Munc13-4 Is a Rab11-binding protein that regulates Rab11-positive vesicle trafficking and docking at the plasma membrane  Academic Article
• Munc13-4 interacts with syntaxin 7 and regulates late endosomal maturation, endosomal signaling, and TLR9-initiated cellular responses  Academic Article
• Murine antibody responses to cleaved soluble HIV-1 envelope trimers are highly restricted in specificity  Academic Article
• Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis  Academic Article
• N-cadherin regulates mammary tumor cell migration through Akt3 suppression  Academic Article
• N332-directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function  Academic Article
• NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells  Academic Article
• NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component  Academic Article
• New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases  Academic Article
• Non-canonical Hedgehog/AMPK-mediated control of polyamine metabolism supports neuronal and medulloblastoma cell growth  Academic Article
• Non-degradative ubiquitination of protein kinases  Academic Article
• Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3  Academic Article
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• PRMT5 modulates the metabolic response to fasting signals  Academic Article
• PRMT5-mediated regulation of developmental myelination  Academic Article
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• Pharmacological and behavioral profile of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-6-chinolincarboxamide (EVP-5141), a novel α7 nicotinic acetylcholine receptor agonist/serotonin 5-HT3 receptor antagonist  Academic Article
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• Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic  Academic Article
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• Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120  Academic Article
• Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models  Academic Article
• Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand  Academic Article
• Suppressors of superoxide production from mitochondrial complex III  Academic Article
• Synthesis and activity of substituted heteroaromatics as positive allosteric modulators for α4β2α5 nicotinic acetylcholine receptors  Academic Article
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• Synthesis and biological evaluation of manassantin analogues for hypoxia-inducible factor 1α inhibition  Academic Article
• Synthesis of sesquiterpene-inspired derivatives designed for covalent binding and their inhibition of the NF-κB pathway  Academic Article
• Synthetic mammalian riboswitches based on guanine aptazyme  Academic Article
• Systematic analysis of bacterial effector-postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domain interactions demonstrates Shigella OspE protein promotes protein kinase C activation via PDLIM proteins  Academic Article
• T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component  Academic Article
• TMIE is an essential component of the mechanotransduction machinery of cochlear hair cells  Academic Article
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• TRPM1 forms complexes with nyctalopin in vivo and accumulates in postsynaptic compartment of ON-bipolar neurons in mGluR6-dependent manner  Academic Article
• Targeted Fcγ receptor (FcγR)-mediated clearance by a biparatopic bispecific antibody  Academic Article
• Targeted disruption of Myc-Max oncoprotein complex by a small molecule  Academic Article
• Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery  Academic Article
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• The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal gamma delta T cell function  Academic Article
• The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation  Academic Article
• The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation  Academic Article
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• The centriolar satellite protein CCDC66 interacts with CEP290 and functions in cilium formation and trafficking  Academic Article
• The clustered protocadherins Pcdh(alpha) and Pcdh(gamma) form a heteromeric complex in zebrafish  Academic Article
• The combination of i-leader truncation and gemcitabine improves oncolytic adenovirus efficacy in an immunocompetent model  Academic Article
• The costimulatory immunogen LPS induces the B-cell clones that infiltrate transplanted human kidneys  Academic Article
• The critical role of membralin in postnatal motor neuron survival and disease  Academic Article
• The crystal structure of the alpha-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function  Academic Article
• The dynamics and mechanism of SUMO chain deconjugation by SUMO-specific proteases  Academic Article
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• The glycan shield of hiv is predominantly oligomannose independently of production system or viral clade  Academic Article
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• The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming  Academic Article
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• The regulatory T cell lineage factor Foxp3 regulates gene expression through several distinct mechanisms mostly independent of direct DNA binding  Academic Article
• The role of Drosophila Piezo in mechanical nociception  Academic Article
• The role of a sodium ion binding site in the allosteric modulation of the A2A adenosine G protein-coupled receptor  Academic Article
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• Translational attenuation differentially alters the fate of disease-associated fibulin proteins  Academic Article
• Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models  Academic Article
• Two- and three-dimensional live cell imaging of DNA damage response proteins  Academic Article
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• Tyrosine cross-linking reveals interfacial dynamics in adeno-associated viral capsids during infection  Academic Article
• UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs  Academic Article
• Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain  Academic Article
• Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops  Academic Article
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• Well-ordered trimeric HIV-1 subtype B and C soluble spike mimetics generated by negative selection display native-like properties  Academic Article
• Withaferin A analogs that target the AAA plus chaperone p97  Academic Article
• YME1L degradation reduces mitochondrial proteolytic capacity during oxidative stress  Academic Article
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• alpha-Catenin interacts with APC to regulate beta-catenin proteolysis and transcriptional repression of Wnt target genes  Academic Article
• eCD4-Ig variants that more potently neutralize HIV-1  Academic Article
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• tRNA synthetase counteracts c-Myc to develop functional vasculature  Academic Article
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