subject area of
- A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals Academic Article
- A method for identification of hiv gp140 binding memory b cells in human blood Academic Article
- A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene Academic Article
- A next-generation cleaved, soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies Academic Article
- Adhesion and fusion efficiencies of human immunodeficiency virus type 1 (HIV-1) surface proteins Academic Article
- Affinity maturation of a potent family of HIV antibodies is primarily focused on accommodating or avoiding glycans Academic Article
- An HIV-1 envelope glycoprotein trimer with an embedded IL-21 domain activates human B cells Academic Article
- Analysis of the interaction of the human immunodeficiency virus type 1 gp120 envelope glycoprotein with the gp41 transmembrane glycoprotein Academic Article
- Anti-HIV B Cell lines as candidate vaccine biosensors Academic Article
- Antibodies from Rabbits Immunized with HIV-1 Clade B SOSIP Trimers Can Neutralize Multiple Clade B Viruses by Destabilizing the Envelope Glycoprotein Academic Article
- Antibody 8ANC195 reveals a site of broad vulnerability on the HIV-1 envelope spike Academic Article
- Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env Academic Article
- Antibody responses to envelope glycoproteins in HIV-1 infection Academic Article
- Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9 Academic Article
- B cell recognition of the conserved hiv-1 co-receptor binding site is altered by endogenous primate cd4 Academic Article
- Biochemical and immunogenic characterization of soluble human immunodeficiency virus type 1 envelope glycoprotein trimers expressed by semliki forest virus Academic Article
- Biochemically defined hiv-1 envelope glycoprotein variant immunogens display differential binding and neutralizing specificities to the cd4-binding site Academic Article
- Blys-mediated modulation of naive b cell subsets impacts hiv env-induced antibody responses Academic Article
- Bone marrow plasma cells are a primary source of serum HIV-1-specific antibodies in chronically infected individuals Academic Article
- Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals Academic Article
- Broadly cross-reactive hiv-1-neutralizing human monoclonal fab selected for binding to gp120-cd4-ccr5 complexes Academic Article
- Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses Academic Article
- Broadly neutralizing antibody responses in a large longitudinal Sub-Saharan HIV primary infection cohort Academic Article
- CD4-induced T-20 binding to human immunodeficiency virus type 1 gp120 blocks interaction with the CXCR4 coreceptor Academic Article
- CD4-induced activation in a soluble HIV-1 Env trimer Academic Article
- Challenges for structure-based HIV vaccine design Academic Article
- Characterization of antibody responses elicited by human immunodeficiency virus type 1 primary isolate trimeric and monomeric envelope glycoproteins in selected adjuvants Academic Article
- Chemical cross-linking stabilizes native-like HIV-1 envelope glycoprotein trimer antigens Academic Article
- Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation Academic Article
- Cleavage-independent HIV-1 Env trimers engineered as soluble native spike mimetics for vaccine design Academic Article
- Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer Academic Article
- Conformational changes induced in the envelope glycoproteins of the human and simian immunodeficiency viruses by soluble receptor binding Academic Article
- Cooperation between somatic mutation and germline-encoded residues enables antibody recognition of HIV-1 envelope glycans Academic Article
- Covalent linkage of HIV-1 trimers to synthetic liposomes elicits improved B cell and antibody responses Academic Article
- Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer Academic Article
- Crystal structure of a soluble cleaved HIV-1 envelope trimer Academic Article
- Dense array of spikes on HIV-1 virion particles Academic Article
- Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens Academic Article
- Detection of minority resistance during early HIV-1 infection: natural variation and spurious detection rather than transmission and evolution of multiple viral variants Academic Article
- Determinants flanking the cd4 binding loop modulate macrophage tropism of human immunodeficiency virus type 1 r5 envelopes Academic Article
- Direct expression and validation of phage-selected peptide variants in mammalian cells Academic Article
- Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization Academic Article
- Diverse antibody genetic and recognition properties revealed following HIV-1 envelope glycoprotein immunization Academic Article
- Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer Academic Article
- Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies Academic Article
- Envelope glycoprotein internalization protects human and simian immunodeficiency virus-infected cells from antibody-dependent cell-mediated cytotoxicity Academic Article
- Evolution of CCR5 use before and during coreceptor switching Academic Article
- Extreme genetic divergence is required for coreceptor switching in HIV-1 subtype C Academic Article
- Focused dampening of antibody response to the immunodominant variable loops by engineered soluble gp140 Academic Article
- Frequency and phenotype of human immunodeficiency virus envelope-specific b cells from patients with broadly cross-neutralizing antibodies Academic Article
- Functional stability of HIV-1 envelope trimer affects accessibility to broadly neutralizing antibodies at its apex Academic Article
- Functional stability of unliganded envelope glycoprotein spikes among isolates of human immunodeficiency virus type 1 (HIV-1) Academic Article
- HIV envelope glycoform heterogeneity and localized diversity govern the initiation and maturation of a V2 apex broadly neutralizing antibody lineage Academic Article
- HIV-1 envelope glycoprotein trimer immunogenicity elicited in the presence of human CD4 alters the neutralization profile Academic Article
- HIV-1 neutralizing antibodies induced by native-like envelope trimers Academic Article
- HIV-1 neutralizing antibodies induced by native-like envelope trimers Academic Article
- Hiv-1 env(gp140) trimers elicit neutralizing antibodies without efficient induction of conformational antibodies Academic Article
- Human immunodeficiency virus type 1 env trimer immunization of macaques and impact of priming with viral vector or stabilized core protein Academic Article
- Identification and characterization of a naturally occurring, efficiently cleaved, membrane-bound, clade A HIV-1 Env, suitable for immunogen design, with properties comparable to membrane-bound BG505 Academic Article
- Identification and characterization of a new cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody Academic Article
- Identification of common features in prototype broadly neutralizing antibodies to HIV envelope V2 apex to facilitate vaccine design Academic Article
- Immune Focusing and Enhanced Neutralization Induced by HIV-1 gp140 Chemical Cross-Linking Academic Article
- Immunization for HIV-1 broadly neutralizing antibodies in human Ig knockin mice Academic Article
- Immunization with recombinant hla classes i and ii, hiv-1 gp140, and siv p27 elicits protection against heterologous shiv infection in rhesus macaques Academic Article
- Immunogenic display of purified chemically cross-linked HIV-1 spikes Academic Article
- Immunogenicity of DNA vaccines expressing human immunodeficiency virus type 1 envelope glycoprotein with and without deletions in the v1/2 and v3 regions Academic Article
- Immunogenicity of HIV-1 envelope glycoprotein oligomers Academic Article
- Immunogenicity of stabilized HIV-1 envelope trimers with reduced exposure of non-neutralizing epitopes Academic Article
- In vitro antigen challenge of human antibody libraries for vaccine evaluation: The human immunodeficiency virus type 1 envelope Academic Article
- In-solution virus capture assay helps deconstruct heterogeneous antibody recognition of human immunodeficiency virus type 1 Academic Article
- Increased functional stability and homogeneity of viral envelope spikes through directed evolution Academic Article
- Increased hiv-1 vaccine efficacy against viruses with genetic signatures in env v2 Academic Article
- Independent expansion of epitope-specific plasma cell responses upon HIV-1 envelope glycoprotein immunization Academic Article
- Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein Academic Article
- Influences on the design and purification of soluble, recombinant native-like HIV-1 envelope glycoprotein trimers Academic Article
- Key gp120 glycans pose roadblocks to the rapid development of VRC01-class antibodies in an HIV-1-infected Chinese donor Academic Article
- Ligand accessibility to the HIV-1 Env co-receptor binding site can occur prior to CD4 engagement and is independent of viral tier category Academic Article
- Model building and refinement of a natively glycosylated HIV-1 Env protein by high-resolution cryoelectron microscopy Academic Article
- Modifications of the human immunodeficiency virus envelope glycoprotein enhance immunogenicity for genetic immunization Academic Article
- Murine antibody responses to cleaved soluble HIV-1 envelope trimers are highly restricted in specificity Academic Article
- Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers Academic Article
- Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers Academic Article
- Phase 1 safety and immunogenicity evaluation of a multiclade hiv-1 candidate vaccine delivered by a replication-defective recombinant adenovirus vector Academic Article
- Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM Academic Article
- Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity Academic Article
- Primary infection by a human immunodeficiency virus with atypical coreceptor tropism Academic Article
- Primate immune responses to HIV-1 Env formulated in the saponin-based adjuvant AbISCO-100 in the presence or absence of TLR9 co-stimulation Academic Article
- Pseudovirion particles bearing native HIV envelope trimers facilitate a novel method for generating human neutralizing monoclonal antibodies against HIV Academic Article
- Rational antibody-based HIV-1 vaccine design: current approaches and future directions Academic Article
- Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs. Academic Article
- Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infections Academic Article
- Reducing V3 antigenicity and immunogenicity on soluble, native-like HIV-1 Env SOSIP trimers Academic Article
- Selection of unadapted, pathogenic SHIVs encoding newly transmitted HIV-1 envelope proteins Academic Article
- Selective expansion of hiv-1 envelope glycoprotein-specific b cell subsets recognizing distinct structural elements following immunization Academic Article
- Soluble hiv-1 env trimers in adjuvant elicit potent and diverse functional b cell responses in primates Academic Article
- Solution conformation of an immunogenic peptide derived from the principal neutralizing determinant of the HIV-2 envelope glycoprotein gp125 Academic Article
- Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice Academic Article
- Stabilization of a soluble, native-like trimeric form of an efficiently cleaved Indian HIV-1 clade C envelope glycoprotein Academic Article
- Stable 293 T and CHO cell lines expressing cleaved, stable HIV-1 envelope glycoprotein trimers for structural and vaccine studies Academic Article
- Structural and functional evaluation ofde novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens Academic Article
- Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates Academic Article
- Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins Academic Article
- Structural basis of glycan276-dependent recognition by HIV-1 broadly neutralizing antibodies Academic Article
- Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers Academic Article
- Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization Academic Article
- Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence Academic Article
- Structure of 2G12 Fab2 in complex with soluble and fully glycosylated HIV-1 Env by negative-stain single-particle electron microscopy Academic Article
- Structure-based vaccine design in hiv: Blind men and the elephant? Academic Article
- Structure-guided redesign increases the propensity of HIV Env to generate highly stable soluble trimers Academic Article
- Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120 Academic Article
- Targeted selection of HIV-specific antibody mutations by engineering B cell maturation Academic Article
- Targeting the HIV-1 spike and coreceptor with bi- and trispecific antibodies for single-component broad inhibition of entry Academic Article
- The C3/465 glycan hole cluster in BG505 HIV-1 envelope is the major neutralizing target involved in preventing mucosal SHIV infection Academic Article
- The Glycan Hole Area of HIV-1 Envelope Trimers Contributes Prominently to the Induction of Autologous Neutralization Academic Article
- The challenges of eliciting neutralizing antibodies to hiv-1 and to influenza virus Academic Article
- The human immunodeficiency virus type 1 envelope spike of primary viruses can suppress antibody access to variable regions Academic Article
- Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures Academic Article
- Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope Academic Article
- V1/V2 neutralizing epitope is conserved in divergent non-M groups of HIV-1 Academic Article
- Vaccine elicitation of high mannose-dependent neutralizing antibodies against the V3-glycan broadly neutralizing epitope in nonhuman primates Academic Article
- Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign Academic Article
- Virus entry via the alternative coreceptors CCR3 and FPRL1 differs by human immunodeficiency virus type 1 subtype Academic Article
- Visualization of the HIV-1 Env glycan shield across scales Academic Article
- Well-ordered trimeric HIV-1 subtype B and C soluble spike mimetics generated by negative selection display native-like properties Academic Article