subject area of

• A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals  Academic Article
• A method for identification of hiv gp140 binding memory b cells in human blood  Academic Article
• A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene  Academic Article
• A next-generation cleaved, soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies  Academic Article
• Adhesion and fusion efficiencies of human immunodeficiency virus type 1 (HIV-1) surface proteins  Academic Article
• Affinity maturation of a potent family of HIV antibodies is primarily focused on accommodating or avoiding glycans  Academic Article
• An HIV-1 envelope glycoprotein trimer with an embedded IL-21 domain activates human B cells  Academic Article
• Analysis of the interaction of the human immunodeficiency virus type 1 gp120 envelope glycoprotein with the gp41 transmembrane glycoprotein  Academic Article
• Anti-HIV B Cell lines as candidate vaccine biosensors  Academic Article
• Antibodies from Rabbits Immunized with HIV-1 Clade B SOSIP Trimers Can Neutralize Multiple Clade B Viruses by Destabilizing the Envelope Glycoprotein  Academic Article
• Antibody 8ANC195 reveals a site of broad vulnerability on the HIV-1 envelope spike  Academic Article
• Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env  Academic Article
• Antibody responses to envelope glycoproteins in HIV-1 infection  Academic Article
• Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9  Academic Article
• B cell recognition of the conserved hiv-1 co-receptor binding site is altered by endogenous primate cd4  Academic Article
• Biochemical and immunogenic characterization of soluble human immunodeficiency virus type 1 envelope glycoprotein trimers expressed by semliki forest virus  Academic Article
• Biochemically defined hiv-1 envelope glycoprotein variant immunogens display differential binding and neutralizing specificities to the cd4-binding site  Academic Article
• Blys-mediated modulation of naive b cell subsets impacts hiv env-induced antibody responses  Academic Article
• Bone marrow plasma cells are a primary source of serum HIV-1-specific antibodies in chronically infected individuals  Academic Article
• Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals  Academic Article
• Broadly cross-reactive hiv-1-neutralizing human monoclonal fab selected for binding to gp120-cd4-ccr5 complexes  Academic Article
• Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses  Academic Article
• Broadly neutralizing antibody responses in a large longitudinal Sub-Saharan HIV primary infection cohort  Academic Article
• CD4-induced T-20 binding to human immunodeficiency virus type 1 gp120 blocks interaction with the CXCR4 coreceptor  Academic Article
• CD4-induced activation in a soluble HIV-1 Env trimer  Academic Article
• Challenges for structure-based HIV vaccine design  Academic Article
• Characterization of antibody responses elicited by human immunodeficiency virus type 1 primary isolate trimeric and monomeric envelope glycoproteins in selected adjuvants  Academic Article
• Chemical cross-linking stabilizes native-like HIV-1 envelope glycoprotein trimer antigens  Academic Article
• Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation  Academic Article
• Cleavage-independent HIV-1 Env trimers engineered as soluble native spike mimetics for vaccine design  Academic Article
• Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer  Academic Article
• Conformational changes induced in the envelope glycoproteins of the human and simian immunodeficiency viruses by soluble receptor binding  Academic Article
• Cooperation between somatic mutation and germline-encoded residues enables antibody recognition of HIV-1 envelope glycans  Academic Article
• Covalent linkage of HIV-1 trimers to synthetic liposomes elicits improved B cell and antibody responses  Academic Article
• Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer  Academic Article
• Crystal structure of a soluble cleaved HIV-1 envelope trimer  Academic Article
• Dense array of spikes on HIV-1 virion particles  Academic Article
• Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens  Academic Article
• Detection of minority resistance during early HIV-1 infection: natural variation and spurious detection rather than transmission and evolution of multiple viral variants  Academic Article
• Determinants flanking the cd4 binding loop modulate macrophage tropism of human immunodeficiency virus type 1 r5 envelopes  Academic Article
• Direct expression and validation of phage-selected peptide variants in mammalian cells  Academic Article
• Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization  Academic Article
• Diverse antibody genetic and recognition properties revealed following HIV-1 envelope glycoprotein immunization  Academic Article
• Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer  Academic Article
• Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies  Academic Article
• Envelope glycoprotein internalization protects human and simian immunodeficiency virus-infected cells from antibody-dependent cell-mediated cytotoxicity  Academic Article
• Evolution of CCR5 use before and during coreceptor switching  Academic Article
• Extreme genetic divergence is required for coreceptor switching in HIV-1 subtype C  Academic Article
• Focused dampening of antibody response to the immunodominant variable loops by engineered soluble gp140  Academic Article
• Frequency and phenotype of human immunodeficiency virus envelope-specific b cells from patients with broadly cross-neutralizing antibodies  Academic Article
• Functional stability of HIV-1 envelope trimer affects accessibility to broadly neutralizing antibodies at its apex  Academic Article
• Functional stability of unliganded envelope glycoprotein spikes among isolates of human immunodeficiency virus type 1 (HIV-1)  Academic Article
• HIV envelope glycoform heterogeneity and localized diversity govern the initiation and maturation of a V2 apex broadly neutralizing antibody lineage  Academic Article
• HIV-1 envelope glycoprotein trimer immunogenicity elicited in the presence of human CD4 alters the neutralization profile  Academic Article
• HIV-1 neutralizing antibodies induced by native-like envelope trimers  Academic Article
• HIV-1 neutralizing antibodies induced by native-like envelope trimers  Academic Article
• Hiv-1 env(gp140) trimers elicit neutralizing antibodies without efficient induction of conformational antibodies  Academic Article
• Human immunodeficiency virus type 1 env trimer immunization of macaques and impact of priming with viral vector or stabilized core protein  Academic Article
• Identification and characterization of a naturally occurring, efficiently cleaved, membrane-bound, clade A HIV-1 Env, suitable for immunogen design, with properties comparable to membrane-bound BG505  Academic Article
• Identification and characterization of a new cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody  Academic Article
• Identification of common features in prototype broadly neutralizing antibodies to HIV envelope V2 apex to facilitate vaccine design  Academic Article
• Immune Focusing and Enhanced Neutralization Induced by HIV-1 gp140 Chemical Cross-Linking  Academic Article
• Immunization for HIV-1 broadly neutralizing antibodies in human Ig knockin mice  Academic Article
• Immunization with recombinant hla classes i and ii, hiv-1 gp140, and siv p27 elicits protection against heterologous shiv infection in rhesus macaques  Academic Article
• Immunogenic display of purified chemically cross-linked HIV-1 spikes  Academic Article
• Immunogenicity of DNA vaccines expressing human immunodeficiency virus type 1 envelope glycoprotein with and without deletions in the v1/2 and v3 regions  Academic Article
• Immunogenicity of HIV-1 envelope glycoprotein oligomers  Academic Article
• Immunogenicity of stabilized HIV-1 envelope trimers with reduced exposure of non-neutralizing epitopes  Academic Article
• In vitro antigen challenge of human antibody libraries for vaccine evaluation: The human immunodeficiency virus type 1 envelope  Academic Article
• In-solution virus capture assay helps deconstruct heterogeneous antibody recognition of human immunodeficiency virus type 1  Academic Article
• Increased functional stability and homogeneity of viral envelope spikes through directed evolution  Academic Article
• Increased hiv-1 vaccine efficacy against viruses with genetic signatures in env v2  Academic Article
• Independent expansion of epitope-specific plasma cell responses upon HIV-1 envelope glycoprotein immunization  Academic Article
• Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein  Academic Article
• Influences on the design and purification of soluble, recombinant native-like HIV-1 envelope glycoprotein trimers  Academic Article
• Key gp120 glycans pose roadblocks to the rapid development of VRC01-class antibodies in an HIV-1-infected Chinese donor  Academic Article
• Ligand accessibility to the HIV-1 Env co-receptor binding site can occur prior to CD4 engagement and is independent of viral tier category  Academic Article
• Model building and refinement of a natively glycosylated HIV-1 Env protein by high-resolution cryoelectron microscopy  Academic Article
• Modifications of the human immunodeficiency virus envelope glycoprotein enhance immunogenicity for genetic immunization  Academic Article
• Murine antibody responses to cleaved soluble HIV-1 envelope trimers are highly restricted in specificity  Academic Article
• Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers  Academic Article
• Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers  Academic Article
• Phase 1 safety and immunogenicity evaluation of a multiclade hiv-1 candidate vaccine delivered by a replication-defective recombinant adenovirus vector  Academic Article
• Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM  Academic Article
• Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity  Academic Article
• Primary infection by a human immunodeficiency virus with atypical coreceptor tropism  Academic Article
• Primate immune responses to HIV-1 Env formulated in the saponin-based adjuvant AbISCO-100 in the presence or absence of TLR9 co-stimulation  Academic Article
• Pseudovirion particles bearing native HIV envelope trimers facilitate a novel method for generating human neutralizing monoclonal antibodies against HIV  Academic Article
• Rational antibody-based HIV-1 vaccine design: current approaches and future directions  Academic Article
• Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs.  Academic Article
• Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infections  Academic Article
• Reducing V3 antigenicity and immunogenicity on soluble, native-like HIV-1 Env SOSIP trimers  Academic Article
• Selection of unadapted, pathogenic SHIVs encoding newly transmitted HIV-1 envelope proteins  Academic Article
• Selective expansion of hiv-1 envelope glycoprotein-specific b cell subsets recognizing distinct structural elements following immunization  Academic Article
• Soluble hiv-1 env trimers in adjuvant elicit potent and diverse functional b cell responses in primates  Academic Article
• Solution conformation of an immunogenic peptide derived from the principal neutralizing determinant of the HIV-2 envelope glycoprotein gp125  Academic Article
• Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice  Academic Article
• Stabilization of a soluble, native-like trimeric form of an efficiently cleaved Indian HIV-1 clade C envelope glycoprotein  Academic Article
• Stable 293 T and CHO cell lines expressing cleaved, stable HIV-1 envelope glycoprotein trimers for structural and vaccine studies  Academic Article
• Structural and functional evaluation ofde novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens  Academic Article
• Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates  Academic Article
• Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins  Academic Article
• Structural basis of glycan276-dependent recognition by HIV-1 broadly neutralizing antibodies  Academic Article
• Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers  Academic Article
• Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization  Academic Article
• Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence  Academic Article
• Structure of 2G12 Fab2 in complex with soluble and fully glycosylated HIV-1 Env by negative-stain single-particle electron microscopy  Academic Article
• Structure-based vaccine design in hiv: Blind men and the elephant?  Academic Article
• Structure-guided redesign increases the propensity of HIV Env to generate highly stable soluble trimers  Academic Article
• Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120  Academic Article
• Targeted selection of HIV-specific antibody mutations by engineering B cell maturation  Academic Article
• Targeting the HIV-1 spike and coreceptor with bi- and trispecific antibodies for single-component broad inhibition of entry  Academic Article
• The C3/465 glycan hole cluster in BG505 HIV-1 envelope is the major neutralizing target involved in preventing mucosal SHIV infection  Academic Article
• The Glycan Hole Area of HIV-1 Envelope Trimers Contributes Prominently to the Induction of Autologous Neutralization  Academic Article
• The challenges of eliciting neutralizing antibodies to hiv-1 and to influenza virus  Academic Article
• The human immunodeficiency virus type 1 envelope spike of primary viruses can suppress antibody access to variable regions  Academic Article
• Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures  Academic Article
• Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope  Academic Article
• V1/V2 neutralizing epitope is conserved in divergent non-M groups of HIV-1  Academic Article
• Vaccine elicitation of high mannose-dependent neutralizing antibodies against the V3-glycan broadly neutralizing epitope in nonhuman primates  Academic Article
• Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign  Academic Article
• Virus entry via the alternative coreceptors CCR3 and FPRL1 differs by human immunodeficiency virus type 1 subtype  Academic Article
• Visualization of the HIV-1 Env glycan shield across scales  Academic Article
• Well-ordered trimeric HIV-1 subtype B and C soluble spike mimetics generated by negative selection display native-like properties  Academic Article