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Enediynes

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  • A free-standing condensation enzyme catalyzing ester bond formation in c-1027 biosynthesis  Academic Article
  • A new member of the 4-methylideneimidazole-5-one-containing aminomutase family from the enediyne kedarcidin biosynthetic pathway  Academic Article
  • A novel 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic c-1027 biosynthesis  Academic Article
  • A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis  Academic Article
  • A total synthesis trilogy: Calicheamicin gamma 1i, taxol (r), and brevetoxin a  Academic Article
  • Biochemical characterization of the sgca1 alpha-d-glucopyranosyl-1-phosphate thymidylyltransferase from the enediyne antitumor antibiotic c-1027 biosynthetic pathway and overexpression of sgca1 in streptomyces globisporus to improve c-1027 production  Academic Article
  • Biosynthesis of enediyne antitumor antibiotics  Academic Article
  • Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic c-1027 featuring beta-amino acyl-s-carrier protein intermediates  Academic Article
  • Biosynthesis of the enediyne antitumor antibiotic c-1027  Academic Article
  • Biosynthesis of the enediyne antitumor antibiotic c-1027 involves a new branching point in chorismate metabolism  Academic Article
  • C-1027, a radiomimetic enediyne anticancer drug, preferentially targets hypoxic cells  Academic Article
  • Cell-specific regulation of apoptosis by designed enediynes  Academic Article
  • Characterization of sgce6, the flavin reductase component supporting fad-dependent halogenation and hydroxylation in the biosynthesis of the enediyne antitumor antibiotic c-1027  Academic Article
  • Characterization of the maduropeptin biosynthetic gene cluster from actinomadura madurae atcc 39144 supporting a unifying paradigm for enediyne biosynthesis  Academic Article
  • Characterization of the two-component, fad-dependent monooxygenase sgcc that requires carrier protein-tethered substrates for the biosynthesis of the enediyne antitumor antibiotic c-1027  Academic Article
  • Chemistry and biology of natural and designed enediynes  Academic Article
  • Cloning and sequencing of the kedarcidin biosynthetic gene cluster from streptoalloteichus sp atcc 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics  Academic Article
  • Conversion of enediynes into quinones by antibody catalysis and in aqueous buffers: Implications for an alternative enediynes therapeutic mechanism  Academic Article
  • Cytochrome P450 Hydroxylase TnmL Catalyzing Sequential Hydroxylation with an Additional Proofreading Activity in Tiancimycin Biosynthesis  Academic Article
  • Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses  Academic Article
  • Enediyne antitumor antibiotic maduropeptin biosynthesis featuring a c-methyltransferase that acts on a coa-tethered aromatic substrate  Academic Article
  • Enediynes: Exploration of microbial genomics to discover new anticancer drug leads  Academic Article
  • Genes for production of the enediyne antitumor antibiotic c-1027 in streptomyces globisporus are clustered with the caga gene that encodes the c-1027 apoprotein  Academic Article
  • Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery  Academic Article
  • Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery  Academic Article
  • Improvement of secondary metabolite production in streptomyces by manipulating pathway regulation  Academic Article
  • Improvement of the enediyne antitumor antibiotic c-1027 production by manipulating its biosynthetic pathway regulation in streptomyces globisporus  Academic Article
  • In vivo efficacy of novel synthetic enediynes 1  Academic Article
  • Inspirations, discoveries, and future perspectives in total synthesis  Academic Article
  • Kinetic analysis of the 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic c-1027 biosynthesis  Academic Article
  • Manipulation of pathway regulation in streptomyces globisporus for overproduction of the enediyne antitumor antibiotic c-1027  Academic Article
  • Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin  Academic Article
  • Polyketide synthase chemistry does not direct biosynthetic divergence between 9-and 10-membered enediynes  Academic Article
  • Predictive Model for Epoxide Hydrolase-Generated Stereochemistry in the Biosynthesis of Nine-Membered Enediyne Antitumor Antibiotics  Academic Article
  • Products of the iterative polyketide synthases in 9-and 10-membered enediyne biosynthesis  Academic Article
  • Regiospecific chlorination of (s)-ss-tyrosyl-s-carrier protein catalyzed by sgcc3 in the biosynthesis of the enediyne antitumor antibiotic c-1027  Academic Article
  • Sequence-selective carbohydrate DNA interaction: Dimeric and monomeric forms of the calicheamicin oligosaccharide interfere with transcription factor function  Academic Article
  • Single chemical modifications of the c-1027 enediyne core, a radiomimetic antitumor drug, affect both drug potency and the role of ataxia-telangiectasia mutated in cellular responses to DNA double-strand breaks  Academic Article
  • Specificity of the ester bond forming condensation enzyme sgcc5 in c-1027 biosynthesis  Academic Article
  • Substrate specificity of the adenylation enzyme sgcc1 involved in the biosynthesis of the enediyne antitumor antibiotic c-1027  Academic Article
  • Supercoiling affects the accessibility of glutathione to DNA-bound molecules: Positive supercoiling inhibits calicheamicin-induced DNA damage  Academic Article
  • Synthesis of the carboline disaccharide domain of shishijimicin a  Academic Article
  • Targeted therapy with a novel enediyene antibiotic calicheamicin theta(i)(1) effectively suppresses growth and dissemination of liver metastases in a syngeneic model of murine neuroblastoma  Academic Article
  • The enediyne antibiotics  Academic Article
  • The radiomimetic enediyne, 20'-deschloro-C-1027 induces inter-strand DNA crosslinks in hypoxic cells and overcomes cytotoxic radioresistance  Academic Article
  • The structure of l-tyrosine 2,3-aminomutase from the c-1027 enediyne antitumor antibiotic biosynthetic pathway  Academic Article
  • Transcriptional effects of the potent enediyne anti-cancer agent calicheamicin gamma  Academic Article

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