subject area of
- A free-standing condensation enzyme catalyzing ester bond formation in c-1027 biosynthesis Academic Article
- A new member of the 4-methylideneimidazole-5-one-containing aminomutase family from the enediyne kedarcidin biosynthetic pathway Academic Article
- A novel 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic c-1027 biosynthesis Academic Article
- A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis Academic Article
- A total synthesis trilogy: Calicheamicin gamma 1i, taxol (r), and brevetoxin a Academic Article
- Biochemical characterization of the sgca1 alpha-d-glucopyranosyl-1-phosphate thymidylyltransferase from the enediyne antitumor antibiotic c-1027 biosynthetic pathway and overexpression of sgca1 in streptomyces globisporus to improve c-1027 production Academic Article
- Biosynthesis of enediyne antitumor antibiotics Academic Article
- Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic c-1027 featuring beta-amino acyl-s-carrier protein intermediates Academic Article
- Biosynthesis of the enediyne antitumor antibiotic c-1027 Academic Article
- Biosynthesis of the enediyne antitumor antibiotic c-1027 involves a new branching point in chorismate metabolism Academic Article
- C-1027, a radiomimetic enediyne anticancer drug, preferentially targets hypoxic cells Academic Article
- Cell-specific regulation of apoptosis by designed enediynes Academic Article
- Characterization of sgce6, the flavin reductase component supporting fad-dependent halogenation and hydroxylation in the biosynthesis of the enediyne antitumor antibiotic c-1027 Academic Article
- Characterization of the maduropeptin biosynthetic gene cluster from actinomadura madurae atcc 39144 supporting a unifying paradigm for enediyne biosynthesis Academic Article
- Characterization of the two-component, fad-dependent monooxygenase sgcc that requires carrier protein-tethered substrates for the biosynthesis of the enediyne antitumor antibiotic c-1027 Academic Article
- Chemistry and biology of natural and designed enediynes Academic Article
- Cloning and sequencing of the kedarcidin biosynthetic gene cluster from streptoalloteichus sp atcc 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics Academic Article
- Conversion of enediynes into quinones by antibody catalysis and in aqueous buffers: Implications for an alternative enediynes therapeutic mechanism Academic Article
- Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses Academic Article
- Enediyne antitumor antibiotic maduropeptin biosynthesis featuring a c-methyltransferase that acts on a coa-tethered aromatic substrate Academic Article
- Enediynes: Exploration of microbial genomics to discover new anticancer drug leads Academic Article
- Genes for production of the enediyne antitumor antibiotic c-1027 in streptomyces globisporus are clustered with the caga gene that encodes the c-1027 apoprotein Academic Article
- Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery Academic Article
- Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery Academic Article
- Improvement of secondary metabolite production in streptomyces by manipulating pathway regulation Academic Article
- Improvement of the enediyne antitumor antibiotic c-1027 production by manipulating its biosynthetic pathway regulation in streptomyces globisporus Academic Article
- In vivo efficacy of novel synthetic enediynes 1 Academic Article
- Inspirations, discoveries, and future perspectives in total synthesis Academic Article
- Kinetic analysis of the 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic c-1027 biosynthesis Academic Article
- Manipulation of pathway regulation in streptomyces globisporus for overproduction of the enediyne antitumor antibiotic c-1027 Academic Article
- Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin Academic Article
- Polyketide synthase chemistry does not direct biosynthetic divergence between 9-and 10-membered enediynes Academic Article
- Predictive Model for Epoxide Hydrolase-Generated Stereochemistry in the Biosynthesis of Nine-Membered Enediyne Antitumor Antibiotics Academic Article
- Products of the iterative polyketide synthases in 9-and 10-membered enediyne biosynthesis Academic Article
- Regiospecific chlorination of (s)-ss-tyrosyl-s-carrier protein catalyzed by sgcc3 in the biosynthesis of the enediyne antitumor antibiotic c-1027 Academic Article
- Sequence-selective carbohydrate DNA interaction: Dimeric and monomeric forms of the calicheamicin oligosaccharide interfere with transcription factor function Academic Article
- Single chemical modifications of the c-1027 enediyne core, a radiomimetic antitumor drug, affect both drug potency and the role of ataxia-telangiectasia mutated in cellular responses to DNA double-strand breaks Academic Article
- Specificity of the ester bond forming condensation enzyme sgcc5 in c-1027 biosynthesis Academic Article
- Substrate specificity of the adenylation enzyme sgcc1 involved in the biosynthesis of the enediyne antitumor antibiotic c-1027 Academic Article
- Supercoiling affects the accessibility of glutathione to DNA-bound molecules: Positive supercoiling inhibits calicheamicin-induced DNA damage Academic Article
- Synthesis of the carboline disaccharide domain of shishijimicin a Academic Article
- Targeted therapy with a novel enediyene antibiotic calicheamicin theta(i)(1) effectively suppresses growth and dissemination of liver metastases in a syngeneic model of murine neuroblastoma Academic Article
- The enediyne antibiotics Academic Article
- The radiomimetic enediyne, 20'-deschloro-C-1027 induces inter-strand DNA crosslinks in hypoxic cells and overcomes cytotoxic radioresistance Academic Article
- The structure of l-tyrosine 2,3-aminomutase from the c-1027 enediyne antitumor antibiotic biosynthetic pathway Academic Article
- Transcriptional effects of the potent enediyne anti-cancer agent calicheamicin gamma Academic Article