subject area of

• A TFIIH-associated mediator head is a basal factor of small nuclear spliced leader RNA gene transcription in early-diverged trypanosomes  Academic Article
• A THEMIS:SHP1 complex promotes T-cell survival  Academic Article
• A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway  Academic Article
• A complex of Protocadherin-19 and N-cadherin mediates a novel mechanism of cell adhesion  Academic Article
• A component-based software environment for visualizing large macromolecular assemblies  Academic Article
• A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins  Academic Article
• A fence-like coat for the nuclear pore membrane  Academic Article
• A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase  Academic Article
• A receptor-modifying deamidase in complex with a signaling phosphatase reveals reciprocal regulation  Academic Article
• A sequence-specific transcription activator motif and powerful synthetic variants that bind Mediator using a fuzzy protein interface  Academic Article
• A20 restricts ubiquitination of pro-interleukin-1β protein complexes and suppresses NLRP3 inflammasome activity  Academic Article
• Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions  Academic Article
• Actin filament labels for localizing protein components in large complexes viewed by electron microscopy  Academic Article
• Activation-independent platelet adhesion and aggregation under elevated shear stress  Academic Article
• Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice  Academic Article
• Affinity purification of protein complexes in C. elegans  Academic Article
• An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1  Academic Article
• Analysis of URI nuclear interaction with RPB5 and components of the R2TP/prefoldin-like complex  Academic Article
• Architectures of lipid transport systems for the bacterial outer membrane  Academic Article
• Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKK epsilon  Academic Article
• Assembly of multi-tRNA synthetase complex via heterotetrameric glutathione transferase-homology domains  Academic Article
• Assembly states of FliM and FliG within the flagellar switch complex  Academic Article
• B cell recognition of the conserved hiv-1 co-receptor binding site is altered by endogenous primate cd4  Academic Article
• BET bromodomain proteins function as master transcription elongation factors independent of CDK9 recruitment  Academic Article
• BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells  Academic Article
• Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex  Academic Article
• Biochemistry. Integrative structural biology  Academic Article
• Catalysis and regulation. Editorial overview  Academic Article
• Cd14 is required for myd88-independent lps signaling  Academic Article
• Cdk1 coordinates cell-surface growth with the cell cycle  Academic Article
• Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair  Academic Article
• Characterization of the 26S proteasome network in Plasmodium falciparum  Academic Article
• Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation  Academic Article
• Circular trimers of gelatinase B/matrix metalloproteinase-9 constitute a distinct population of functional enzyme molecules differentially regulated by tissue inhibitor of metalloproteinases-1  Academic Article
• Condensin I and II complexes license full estrogen receptor α-dependent enhancer activation  Academic Article
• Conformational states of the severe acute respiratory syndrome coronavirus spike protein ectodomain  Academic Article
• Control of developmental regulator's by Polycomb in human embryonic stem cells  Academic Article
• Cooperativity in macromolecular assembly  Academic Article
• Crystal structure of a Cbtx-AChBP complex reveals essential interactions between snake alpha-neurotoxins and nicotinic receptors  Academic Article
• Crystal structure of a novel manganese-containing cupin (TM1459) from Thermotoga maritima at 1.65 Å resolution  Academic Article
• Crystal structure of an orphan protein (TM0875) from thermotoga maritima at 2.00 Å resolution reveals a new fold  Academic Article
• Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser  Academic Article
• Crystal structure of vinculin in complex with vinculin binding site 50 (VBS50), the integrin binding site 2 (IBS2) of talin  Academic Article
• Design of self-assembling peptide nanotubes with delocalized electronic states  Academic Article
• Detection of a ternary complex of nf-kappa b and i kappa b alpha with DNA provides insights into how i kappa b alpha removes nf-kappa b from transcription sites  Academic Article
• Developmental biology: The early heart remodelled  Academic Article
• Direct binding of SAS-6 to ZYG-1 recruits SAS-6 to the mother centriole for cartwheel assembly  Academic Article
• Disrupted adenovirus-based vaccines against small addictive molecules circumvent anti-adenovirus immunity  Academic Article
• Disulfide isomerization switches tissue factor from coagulation to cell signaling  Academic Article
• E339 ... R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors  Academic Article
• ELF3 recruitment to the PRR9 promoter requires other Evening Complex members in the Arabidopsis circadian clock  Academic Article
• Evidence for annexin II-S100A10 complex and plasmin in mobilization of cytokine activity of human TrpRS  Academic Article
• Evidence for participation of a multiprotein complex in yeast DNA replication in vitro  Academic Article
• Formation of cytotoxic transthyretin is not dependent on inter-molecular disulphide bridges commonly found within the amyloid form  Academic Article
• Functional interaction of heat shock protein 90 and beclin 1 modulates toll-like receptor-mediated autophagy  Academic Article
• Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging  Academic Article
• Girk channel modulation by assembly with allosterically regulated RGS proteins  Academic Article
• Head module control of mediator interactions  Academic Article
• High confidence fission yeast SUMO conjugates identified by tandem denaturing affinity purification  Academic Article
• High-resolution protein complexes from integrating genomic information with molecular simulation  Academic Article
• How TCRs bind MHCs, peptides, and coreceptors  Academic Article
• Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome  Academic Article
• Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease  Academic Article
• Identification and characterization of five new subunits of TRAPP  Academic Article
• Implication of a novel multiprotein Dam1p complex in outer kinetochore function  Academic Article
• Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1  Academic Article
• Inhibitor of MYC identified in a Krohnke pyridine library  Academic Article
• Intrinsically disordered proteins in cellular signalling and regulation  Academic Article
• Isolation and characterization of cytoplasmic cofilin-actin rods  Academic Article
• Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics  Academic Article
• LRRC8 proteins form volume-regulated anion channels that sense ionic strength  Academic Article
• Lyso-sulfatide binds factor Xa and inhibits thrombin generation by the prothrombinase complex  Academic Article
• MAIT recognition of a stimulatory bacterial antigen bound to MR1  Academic Article
• Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells  Academic Article
• Malleable machines take shape in eukaryotic transcriptional regulation  Academic Article
• Mechanism of Ska recruitment by Ndc8 complexes to kinetochores  Academic Article
• Mechanism of aldolase control of sorting nexin 9 function in endocytosis  Academic Article
• Mechanisms for zinc and proton inhibition of the GluN1/GluN2A NMDA receptor  Academic Article
• Metformin inhibits hepatic mTORC1 signaling via dose-dependent mechanisms involving AMPK and the TSC complex  Academic Article
• Mitochondrial complex i activity and nad(+)/nadh balance regulate breast cancer progression  Academic Article
• Molecular analysis of kinetochore architecture in fission yeast  Academic Article
• Molecular architecture and connectivity of the budding yeast Mtw1 kinetochore complex  Academic Article
• Molecular basis of listeriolysin O pH dependence  Academic Article
• Molecular mechanism for the umami taste synergism  Academic Article
• Mre11-rad50-nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks  Academic Article
• Nanodiscs and SILAC-based mass spectrometry to identify a membrane protein interactome  Academic Article
• Native capillary isoelectric focusing for the separation of protein complex isoforms and subcomplexes  Academic Article
• New chemistry for the study of multiprotein complexes: The six-histidine tag as a receptor for a protein crosslinking reagent  Academic Article
• Nob1 binds the single-stranded cleavage site d at the 3 '-end of 18s rRNA with its pin domain  Academic Article
• Novel multiprotein complexes identified in the hyperthermophilic archaeon pyrococcus furiosus by non-denaturing fractionation of the native proteome  Academic Article
• O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability  Academic Article
• Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation  Academic Article
• PEPCK coordinates the regulation of central carbon metabolism to promote cancer cell growth  Academic Article
• PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression  Academic Article
• Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1  Academic Article
• Phosphoregulation of the C. elegans cadherin-catenin complex  Academic Article
• Phosphorylation state defines discrete roles for monopolin in chromosome attachment and spindle elongation  Academic Article
• Polyglutamine-expanded spinocerebellar ataxia-7 protein disrupts normal SAGA and SLIK histone acetyltransferase activity  Academic Article
• Prion strain discrimination using luminescent conjugated polymers  Academic Article
• Probing DNA- and ATP-mediated conformational changes in the MutS family of mispair recognition proteins using deuterium exchange mass spectrometry  Academic Article
• Protein arginine methyltransferase 5 catalyzes substrate dimethylation in a distributive fashion  Academic Article
• Protein kinase C-eta controls CTLA-4-mediated regulatory T cell function  Academic Article
• RCADiA: simple automation platform for comparative multidimensional protein identification technology  Academic Article
• RagA, but not RagB, is essential for embryonic development and adult mice  Academic Article
• Reconstitution of the augmin complex provides insights into its architecture and function  Academic Article
• Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival  Academic Article
• Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks  Academic Article
• Repair complexes of fen1 endonuclease, DNA, and rad9-hus1-rad1 are distinguished from their pcna counterparts by functionally important stability  Academic Article
• Replication-independent histone deposition by the HIR complex and Asf1  Academic Article
• Retention of misfolded mutant transthyretin by the chaperone BiP/GRP78 mitigates amyloidogenesis  Academic Article
• Secreted IGFBP5 mediates mTORC1-dependent feedback inhibition of IGF-1 signalling  Academic Article
• Self-assembling peptide amphiphile nanofiber matrices for cell entrapment  Academic Article
• Structural basis for subversion of cellular control mechanisms by the adenoviral e1a oncoprotein  Academic Article
• Structural basis of IMP3 RRM12 recognition of RNA  Academic Article
• Structural characterization of the Z ring-eIF4E complex reveals a distinct mode of control for eIF4E  Academic Article
• Structural design of cage and coat scaffolds that direct membrane traffic  Academic Article
• Structure and nucleosome interaction of the yeast NuA4 and Piccolo-NuA4 histone acetyltransferase complexes  Academic Article
• Structure of a trimeric nucleoporin complex reveals alternate oligomerization states  Academic Article
• Structure of an RNA polymerase II preinitiation complex  Academic Article
• Structure of eukaryotic Mediator complexes  Academic Article
• Structure of the intact ppar-gamma-rxr-alpha nuclear receptor complex on DNA  Academic Article
• Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs  Academic Article
• Structure of the ternary complex formed by a chemotaxis receptor signaling domain, the CheA histidine kinase, and the coupling protein CheW as determined by pulsed dipolar ESR spectroscopy  Academic Article
• Structures and organization of adenovirus cement proteins provide insights into the role of capsid maturation in virus entry and infection  Academic Article
• Subunit architecture of general transcription factor TFIIH  Academic Article
• Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells  Academic Article
• Techniques: Oxidative cross-linking as an emergent tool for the analysis of receptor-mediated signalling events  Academic Article
• The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assembly  Academic Article
• The ELF4-ELF3-LUX complex links the circadian clock to diurnal control of hypocotyl growth  Academic Article
• The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins  Academic Article
• The Hsp90 chaperone complex regulates GDI-dependent Rab recycling  Academic Article
• The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A  Academic Article
• The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex  Academic Article
• The RCSB Protein Data Bank: views of structural biology for basic and applied research and education  Academic Article
• The RNA-induced silencing complex: A versatile gene-silencing machine  Academic Article
• The action of cardiolipin on the bacterial translocon  Academic Article
• The biological impact of mass-spectrometry-based proteomics  Academic Article
• The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes  Academic Article
• The complex of G protein regulator RGS9-2 and G beta(5) controls sensitization and signaling kinetics of type 5 adenylyl cyclase in the striatum  Academic Article
• The conserved KMN network constitutes the core microtubule-binding site of the kinetochore  Academic Article
• The high-risk HPV16 E7 oncoprotein mediates interaction between the transcriptional coactivator CBP and the retinoblastoma protein pRb  Academic Article
• The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility  Academic Article
• The kinetics of nucleated polymerizations at high concentrations: Amyloid fibril formation near and above the "supercritical concentration''  Academic Article
• The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments  Academic Article
• The novel purification and biochemical characterization of a reversible CYP24A1:adrenodoxin complex  Academic Article
• The structure of the NXF2/NXT1 heterodimeric complex reveals the combined specificity and versatility of the NTF2-like fold  Academic Article
• The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis  Academic Article
• The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis  Academic Article
• The yeast IgI family member Sro7p is an effector of the secretory Rab GTPase Sec4p  Academic Article
• Thiol pathways in the regulation of tissue factor prothrombotic activity  Academic Article
• Three distinct condensin complexes control C. elegans chromosome dynamics  Academic Article
• Toward a general chemical method for rapidly mapping multi-protein complexes  Academic Article
• Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner  Academic Article
• Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth  Academic Article
• Virus capsid expansion driven by the capture of mobile surface loops  Academic Article
• Xiap induces nf-kappa b activation via the bir1/tab1 interaction and bir1 dimerization  Academic Article
• [Molecular mechanism by which plant determines flowering timing with circadian clock]  Academic Article
• mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide  Academic Article
• tea4p links microtubule plus ends with the formin for3p in the establishment of cell polarity  Academic Article