subject area of

• 2-Aminobenzimidazoles as potent Aurora kinase inhibitors  Academic Article
• 68Ga-PSMA-11 PET imaging of response to androgen receptor inhibition: first human experience  Academic Article
• A 3-dimensional extracellular matrix as a delivery system for the transplantation of glioma-targeting neural stem/progenitor cells  Academic Article
• A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy  Academic Article
• A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3β  Academic Article
• A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles  Academic Article
• A combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decay  Academic Article
• A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive clinical, metastatic, developmental, and metabolic characteristics  Academic Article
• A cross-species analysis of a mouse model of breast cancer-specific osteolysis and human bone metastases using gene expression profiling  Academic Article
• A curcumin derivative that inhibits vinyl carbamate-induced lung carcinogenesis via activation of the Nrf2 protective response  Academic Article
• A dual color immunohistochemistry assay for measurement of cereblon in multiple myeloma patient samples  Academic Article
• A fluopol-ABPP HTS assay to identify PAD inhibitors  Academic Article
• A fundamental relationship between hydrophobic properties and biological activity for the duocarmycin class of DNA-alkylating antitumor drugs: hydrophobic-binding-driven bonding  Academic Article
• A general approach for receptor and antibody-targeted detection of native proteins utilizing split-luciferase reassembly  Academic Article
• A genetically encoded aza-Michael acceptor for covalent cross-linking of protein-receptor complexes  Academic Article
• A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing  Academic Article
• A genomic screen identifies TYRO3 as a MITF regulator in melanoma  Academic Article
• A global map of lipid-binding proteins and their ligandability in cells  Academic Article
• A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters  Academic Article
• A large noncoding rna is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas  Academic Article
• A lentiviral vector allowing physiologically regulated membrane-anchored and secreted antibody expression depending on B-cell maturation status  Academic Article
• A monoclonal antibody to ADAM17 inhibits tumor growth by inhibiting EGFR and non-EGFR-Mediated Pathways  Academic Article
• A multifunctional bispecific antibody protects against Pseudomonas aeruginosa  Academic Article
• A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis  Academic Article
• A novel DNA vaccine encoding pdgfr beta suppresses growth and dissemination of murine colon, lung and breast carcinoma  Academic Article
• A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target  Academic Article
• A novel achiral seco-amino-cyclopropylindoline (CI) analog of CC-1065 and the duocarmycins: design, synthesis and biological studies  Academic Article
• A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells  Academic Article
• A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties  Academic Article
• A novel estrogen receptor α-associated protein alters receptor-deoxyribonucleic acid interactions and represses receptor-mediated transcription  Academic Article
• A novel high-affinity human monoclonal antibody to mesothelin  Academic Article
• A novel mode of intervention with serine protease activity: targeting zymogen activation  Academic Article
• A novel neuroprotective agent with antioxidant and nitric oxide synthase inhibitory action  Academic Article
• A novel, unusually efficacious duocarmycin carbamate prodrug that releases no residual byproduct  Academic Article
• A peptide that antagonizes tcr-mediated reactions with both syngeneic and allogeneic agonists: Functional and structural aspects  Academic Article
• A phosphoproteomic analysis of the ErbB2 receptor tyrosine kinase signaling pathways  Academic Article
• A physical sciences network characterization of non-tumorigenic and metastatic cells  Academic Article
• A platform for artificial intelligence based identification of the extravasation potential of cancer cells into the brain metastatic niche  Academic Article
• A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis  Academic Article
• A reversible and highly selective inhibitor of the proteasomal ubiquitin receptor rpn13 is toxic to multiple myeloma cells  Academic Article
• A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors  Academic Article
• A second fatty acid amide hydrolase with variable distribution among placental mammals  Academic Article
• A selective estrogen receptor modulator for the treatment of hot flushes  Academic Article
• A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells  Academic Article
• A short n-terminal sequence of pten controls cytoplasmic localization and is required for suppression of cell growth  Academic Article
• A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase  Academic Article
• A small molecule inhibitor of α4 integrin-dependent cell migration  Academic Article
• A small molecule inhibits deregulated NRF2 transcriptional activity in cancer  Academic Article
• A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth  Academic Article
• A small molecule modulates circadian rhythms through phosphorylation of the period protein  Academic Article
• A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein  Academic Article
• A small-molecule antagonist of the hedgehog signaling pathway  Academic Article
• A stapled p53 helix overcomes HDMX-mediated suppression of p53  Academic Article
• A structure-guided approach to creating covalent FGFR inhibitors  Academic Article
• A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors  Academic Article
• A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity  Academic Article
• A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy  Academic Article
• A system-wide investigation of the dynamics of Wnt signaling reveals novel phases of transcriptional regulation  Academic Article
• A two-hit mechanism for pre-mitotic arrest of cancer cell proliferation by a polyamide-alkylator conjugate  Academic Article
• A unique class of duocarmycin and CC-1065 analogues subject to reductive activation  Academic Article
• AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin  Academic Article
• ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1  Academic Article
• ATP induces protein arginine deiminase 2-dependent citrullination in mast cells through the P2X7 purinergic receptor  Academic Article
• ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A  Academic Article
• Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness  Academic Article
• Aberrant, persistent inclusion into lipid rafts limits the tumorigenic function of membrane type-1 matrix metalloproteinase in malignant cells  Academic Article
• Abnormal tau induces cognitive impairment through two different mechanisms: synaptic dysfunction and neuronal loss  Academic Article
• Absence of CTL responses to early viral antigens facilitates viral persistence  Academic Article
• Activating transcription factor 4 increases chemotherapeutics resistance of human hepatocellular carcinoma  Academic Article
• Activating transcription factor 4 promotes angiogenesis of breast cancer through enhanced macrophage recruitment  Academic Article
• Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor vii  Academic Article
• Activation of pro-uPA is critical for initial escape from the primary tumor and hematogenous dissemination of human carcinoma cells  Academic Article
• Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer  Academic Article
• Activation of tumor cell integrin alpha(v)beta(3) controls angiogenesis and metastatic growth in the brain  Academic Article
• Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth  Academic Article
• Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins  Academic Article
• Activity-based protein profiling implicates urokinase activation as a key step in human fibrosarcoma intravasation  Academic Article
• Activity-based protein profiling of oncogene-driven changes in metabolism reveals broad dysregulation of PAFAH1B2 and 1B3 in cancer  Academic Article
• Activity-based protein profiling of protein arginine methyltransferase 1  Academic Article
• Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474  Academic Article
• Adeno-associated virus enhances wild-type and oncolytic adenovirus spread  Academic Article
• Adenoviral-mediated, intratumor gene transfer of interleukin 23 induces a therapeutic antitumor response  Academic Article
• Adipocytes contribute to the growth and progression of multiple myeloma: Unraveling obesity related differences in adipocyte signaling  Academic Article
• Adjuvant therapy with agonistic antibodies to CD134 (OX40) increases local control after surgical or radiation therapy of cancer in mice  Academic Article
• Advantages and limitations of particle-mediated transfection (gene gun) in cancer immuno-gene therapy using IL-10, IL-12 or B7-1 in murine tumor models  Academic Article
• Akt demoted in glioblastoma  Academic Article
• Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation  Academic Article
• Akt-mediated phosphorylation of argonaute 2 downregulates cleavage and upregulates translational repression of MicroRNA targets  Academic Article
• Aldolase antibody activation of prodrugs of potent aldehyde-containing cytotoxics for selective chemotherapy  Academic Article
• Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells  Academic Article
• Allosteric control of ligand selectivity between estrogen receptors alpha and beta: Implications for other nuclear receptors  Academic Article
• Allosteric inhibition of hypoxia inducible factor-2 with small molecules  Academic Article
• Alteration of the bis-tetrahydrofuran core stereochemistries in asimicin can affect the cytotoxicity  Academic Article
• Altered trafficking of FAS and subsequent resistance to FAS-mediated apoptosis occurs by a wild-type p53 independent mechanism in esophageal adenocarcinoma  Academic Article
• Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase  Academic Article
• Alternatively spliced tissue factor promotes breast cancer growth in a beta 1 integrin-dependent manner  Academic Article
• Alzheimer's Aβ peptides containing an isostructural backbone mutation afford distinct aggregate morphologies but analogous cytotoxicity. Evidence for a common low-abundance toxic structure(s)?  Academic Article
• An Mtb-human protein-protein interaction map identifies a switch between host antiviral and antibacterial responses  Academic Article
• An activity-based imaging probe for the integral membrane hydrolase KIAA1363  Academic Article
• An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth  Academic Article
• An anti-B cell maturation antigen bispecific antibody for multiple myeloma  Academic Article
• An efficient chemical approach to bispecific antibodies and antibodies of high valency  Academic Article
• An endophytic Neurospora sp. from Nothapodytes foetida producing camptothecin  Academic Article
• An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling  Academic Article
• An immunoglobulin Cκ-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system  Academic Article
• An in vivo tagging method reveals that Ras undergoes sustained activation upon transglutaminase-mediated protein serotonylation  Academic Article
• An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer  Academic Article
• An integrated transcriptomic and meta-analysis of hepatoma cells reveals factors that influence susceptibility to HCV infection  Academic Article
• Analysis of URI nuclear interaction with RPB5 and components of the R2TP/prefoldin-like complex  Academic Article
• Analysis of cell-cell contact mediated by Ig superfamily cell adhesion molecules  Academic Article
• Analysis of microRNAs expressions in chondrosarcoma  Academic Article
• Androgen receptor splice variants determine taxane sensitivity in prostate cancer  Academic Article
• Androgen receptor upregulation mediates radioresistance after ionizing radiation  Academic Article
• Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor  Academic Article
• Annotating STEAP1 regulation in prostate cancer with (89)Zr immuno-PET  Academic Article
• Anti-inflammatory activity in vitro and in vivo of the protein farnesyltransferase inhibitor tipifarnib  Academic Article
• Anti-lung cancer activity and inhibitory mechanisms of a novel Calothrixin A derivative  Academic Article
• Anti-proliferative actions of a synthetic REV-ERBα/β agonist in breast cancer cells  Academic Article
• Anti-tumor and immunomodulatory activity of resveratrol in vitro and its potential for combining with cancer immunotherapy  Academic Article
• Antibody microarrays utilizing site-specific antibody-oligonucleotide conjugates  Academic Article
• Antibody-dependent cell-mediated cytotoxicity effector-enhanced EphA2 agonist monoclonal antibody demonstrates potent activity against human tumors  Academic Article
• Anticancer properties of distinct antimalarial drug classes  Academic Article
• Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor  Academic Article
• Antigen-specific cytotoxicity by invariant NKT cells in vivo is CD95/CD178-dependent and is correlated with antigenic potency  Academic Article
• Antinuclear autoantibodies in prostate cancer: immunity to LEDGF/p75, a survival protein highly expressed in prostate tumors and cleaved during apoptosis  Academic Article
• Antischistosomal versus antiandrogenic properties of aryl hydantoin Ro 13-3978  Academic Article
• Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase  Academic Article
• Antitumor effects and mechanisms ofAZD4547on FGFR2-deregulated endometrial cancer cells  Academic Article
• Apoptotic tumor cells induce il-27 release from human dcs to activate treg cells that express cd69 and attenuate cytotoxicity  Academic Article
• Applying PET to broaden the diagnostic utility of the clinically validated CA19.9 serum biomarker for oncology  Academic Article
• Apurinic/apyrimidinic endonuclease 1 alters estrogen receptor activity and estrogen-responsive gene expression  Academic Article
• Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKK epsilon  Academic Article
• Arresting cancer proliferation by small-molecule gene regulation  Academic Article
• Arylsulfonamide kcn1 inhibits in vivo glioma growth and interferes with hif signaling by disrupting hif-1 alpha interaction with cofactors p300/cbp  Academic Article
• Assessing compound binding to the Eg5 motor domain using a thermal shift assay  Academic Article
• Assessing enzyme activities using stable isotope labeling and mass spectrometry  Academic Article
• Assessment of therapeutic efficacy of liposomal nanoparticles mediated gene delivery by molecular imaging for cancer therapy  Academic Article
• Association with the plasma membrane is sufficient for potentiating catalytic activity of regulators of G protein signaling (RGS) proteins of the R7 subfamily  Academic Article
• Asymmetric synthesis and biological properties of uncialamycin and 26-epi-uncialamycin  Academic Article
• Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase  Academic Article
• Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells  Academic Article
• Automated screening of microtubule growth dynamics identifies MARK2 as a regulator of leading edge microtubules downstream of Rac1 in migrating cells  Academic Article
• Autophagy-regulated ROS from xanthine oxidase acts as an early effector for triggering late mitochondria-dependent apoptosis in cathepsin S-targeted tumor cells  Academic Article
• Avidity of cd1d-ligand-receptor ternary complex contributes to t-helper 1 (th1) polarization and anticancer efficacy  Academic Article
• Azaxanthene based selective glucocorticoid receptor modulators: design, synthesis, and pharmacological evaluation of (S)-4-(5-(1-((1,3,4-thiadiazol-2-yl)amino)-2-methyl-1-oxopropan-2-yl)-5H-chromeno[2,3-b]pyridin-2-yl)-2-fluoro-N,N-dimethylbenzamide (BMS-776532) and its methylene homologue (BMS-791826)  Academic Article
• B-cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention  Academic Article
• BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction  Academic Article
• Background gene expression networks significantly enhance drug response prediction by transcriptional profiling  Academic Article
• Benzazepinones and benzoxazepinones as antagonists of inhibitor of apoptosis proteins (IAPs) selective for the second baculovirus IAP repeat (BIR2) domain  Academic Article
• Beta-lactam-based approach for the chemical programming of aldolase antibody 38c2  Academic Article
• Bidirectional transcription directs both transcriptional gene activation and suppression in human cells  Academic Article
• Bifunctional electrophiles cross-link thioredoxins with redox relay partners in cells  Academic Article
• Biobanking: an important resource for precision medicine in glioblastoma  Academic Article
• Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1  Academic Article
• Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase  Academic Article
• Biomimetic total synthesis of gambogin and rate acceleration of pericyclic reactions in aqueous media  Academic Article
• Biomimetically inspired total synthesis and structure activity relationships of 1-o-methyllateriflorone. 6 pi electrocyclizations in organic synthesis  Academic Article
• Biosynthesis of 14,15-hepoxilins in human l1236 Hodgkin lymphoma cells and eosinophils  Academic Article
• Bipartite functions of the CREB co-activators selectively direct alternative splicing or transcriptional activation  Academic Article
• Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors  Academic Article
• Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors  Academic Article
• Blocking lactate export by inhibiting the Myc target MCT1 disables glycolysis and glutathione synthesis  Academic Article
• Bortezomib resistance in mantle cell lymphoma is associated with plasmacytic differentiation  Academic Article
• Both scf(cdc4 alpha) and scf(cdc4 gamma) are required for cyclin e turnover in cell lines that do not overexpress cyclin e  Academic Article
• Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1  Academic Article
• Breadth of neutralization and synergy of clinically relevant human monoclonal antibodies against HCV genotypes 1a, 1b, 2a, 2b, 2c, and 3a  Academic Article
• Breaking the one antibody-one target axiom  Academic Article
• Breast cancer cell lines grown in vivo: What goes in isn't always the same as what comes out  Academic Article
• Broad anti-tumor activity of a small molecule that selectively targets the Warburg effect and lipogenesis  Academic Article
• Brusatol overcomes chemoresistance through inhibition of protein translation  Academic Article
• Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1  Academic Article
• Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax  Academic Article
• CBP is a dosage-dependent regulator of nuclear factor-kappa B suppression by the estrogen receptor  Academic Article
• CD200 expression on tumor cells suppresses antitumor immunity: new approaches to cancer immunotherapy  Academic Article
• CDC25B mediates rapamycin-induced oncogenic responses in cancer cells  Academic Article
• CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability  Academic Article
• CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma  Academic Article
• CEBPA-dependent HK3 and KLF5 expression in primary AML and during AML differentiation  Academic Article
• CLEC5A (MDL-1) is a novel PU.1 transcriptional target during myeloid differentiation  Academic Article
• CS1, a potential new therapeutic antibody target for the treatment of multiple myeloma  Academic Article
• CXCR4 activation maintains a stem cell population in tamoxifen-resistant breast cancer cells through AhR signalling  Academic Article
• Caged [(18)F]FDG glycosylamines for imaging acidic tumor microenvironments using positron emission tomography  Academic Article
• Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4t1 murine breast cancer model  Academic Article
• Cancer gene therapy using a novel secretable trimeric trail  Academic Article
• Capturing changes in the brain microenvironment during initial steps of breast cancer brain metastasis  Academic Article
• Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo  Academic Article
• Cd22 is a recycling receptor that can shuttle cargo between the cell surface and endosomal compartments of b cells  Academic Article
• Cell based screening of inhibitors of transthyretin aggregation  Academic Article
• Cell growth inhibition and actin cytoskeleton disorganization induced by azaspiracid-1 structure-activity studies  Academic Article
• Cell penetrating peptide amphiphile integrated liposomal systems for enhanced delivery of anticancer drugs to tumor cells  Academic Article
• Cell surface proteomics identifies molecules functionally linked to tumor cell intravasation  Academic Article
• Cell targeting with hybrid Qβ virus-like particles displaying epidermal growth factor  Academic Article
• Cell, isoform, and environment factors shape gradients and modulate chemotaxis  Academic Article
• Cell-specific susceptibility to prion strains is a property of the intact cell  Academic Article
• Cellular cofactors affecting hepatitis C virus infection and replication  Academic Article
• Ceramide triggers budding of exosome vesicles into multivesicular endosomes  Academic Article
• Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays  Academic Article
• Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.  Academic Article
• Characterization of a hypoxia-response element in the Epo locus of the pufferfish, Takifugu rubripes  Academic Article
• Characterization of a side population of astrocytoma cells in response to temozolomide  Academic Article
• Characterization of lassa virus cell entry inhibitors: Determination of the active enantiomer by asymmetric synthesis  Academic Article
• Characterization of stem cell-like cancer cells in immune-competent mice  Academic Article
• Characterization of the human protein S gene promoter: a possible role of transcription factors Sp1 and HNF3 in liver  Academic Article
• Charcot-Marie-Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect  Academic Article
• Chem-seq permits identification of genomic targets of drugs against androgen receptor regulation selected by functional phenotypic screens  Academic Article
• Chemical adaptor immunotherapy: design, synthesis, and evaluation of novel integrin-targeting devices  Academic Article
• Chemical generation of bispecific antibodies  Academic Article
• Chemical proteomics identifies druggable vulnerabilities in a genetically defined cancer  Academic Article
• Chemical synthesis and biological evaluation of palmerolide a analogues  Academic Article
• Chemically programmed antibodies targeting multiple alpha(v) integrins and their effects on tumor-related functions in vitro  Academic Article
• Chemically programmed bispecific antibody targeting legumain protease and avß3 integrin mediates strong antitumor effects  Academic Article
• Chemistry and biology of diazonamide A: Second total synthesis and biological investigations  Academic Article
• Chemo-resistant protein expression pattern of glioblastoma cells (A172) to perillyl alcohol  Academic Article
• Chemoproteomic evaluation of target engagement by the cyclin-dependent kinase 4 and 6 inhibitor palbociclib correlates with cancer cell response  Academic Article
• Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma  Academic Article
• Chemotherapy-resistant human acute myeloid leukemia cells are not enriched for leukemic stem cells but require oxidative metabolism  Academic Article
• Chick embryo chorioallantoic membrane model systems to study and visualize human tumor cell metastasis  Academic Article
• Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription  Academic Article
• Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3  Academic Article
• Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells  Academic Article
• Chromosomal instability estimation based on next generation sequencing and single cell genome wide copy number variation analysis  Academic Article
• Chronophin coordinates cell leading edge dynamics by controlling active cofilin levels  Academic Article
• Cks overexpression enhances chemotherapeutic efficacy by overriding DNA damage checkpoints  Academic Article
• Clathrate nanostructures for mass spectrometry  Academic Article
• Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors  Academic Article
• Cold stress-induced protein rbm3 binds 60s ribosomal subunits, alters rnicrorna levels, and enhances global protein synthesis  Academic Article
• Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer  Academic Article
• Combination of anti-HER3 antibody MM-121/SAR256212 and cetuximab inhibits tumor growth in preclinical models of head and neck squamous cell carcinoma  Academic Article
• Combination therapy targeting both tumor-initiating and differentiated cell populations in prostate carcinoma  Academic Article
• Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer  Academic Article
• Comparative analysis of antitumor activity of CD40L, RANKL, and 4-1BBL in vivo following intratumoral administration of viral vectors or transduced dendritic cells  Academic Article
• Comparative analysis of metastasis variants derived from human prostate carcinoma cells: roles in intravasation of VEGF-mediated angiogenesis and uPA-mediated invasion  Academic Article
• Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues  Academic Article
• Comparison of in vitro and in vivo approaches to studying brain colonization by breast cancer cells  Academic Article
• Complete replication of hepatitis C virus in cell culture  Academic Article
• Comprehensive mapping of histone modifications at DNA double-strand breaks deciphers repair pathway chromatin signatures  Academic Article
• Comprehensive study of sansalvamide a derivatives and their structure-activity relationships against drug-resistant colon cancer cell lines  Academic Article
• Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells  Academic Article
• Conditional regulation of the human CYP4X1 and CYP4Z1 genes  Academic Article
• Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate  Academic Article
• Construction, affinity maturation, and biological characterization of an anti-tumor-associated glycoprotein-72 humanized antibody  Academic Article
• Contributions of thrombin targets to tissue factor-dependent metastasis in hyperthrombotic mice  Academic Article
• Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment  Academic Article
• Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis  Academic Article
• Coumarins hinged directly on benzimidazoles and their ribofuranosides to inhibit hepatitis C virus  Academic Article
• Coupling of receptor conformation and ligand orientation determine graded activity  Academic Article
• Covalent ligand discovery against druggable hotspots targeted by anti-cancer natural products  Academic Article
• Crystal structure of the human n-myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor  Academic Article
• Crystal structures of human HSP90 alpha-complexed with dihydroxyphenylpyrazoles  Academic Article
• Cyclic marinopyrrole derivatives as disruptors of Mcl-1 and Bcl-x(L) binding to Bim  Academic Article
• Cyclin E deregulation promotes loss of specific genomic regions  Academic Article
• Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities  Academic Article
• Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins  Academic Article
• Cycloheximide and congeners as inhibitors of eukaryotic protein synthesis from endophytic actinomycetes streptomyces sps. Yim56132 and yim56141  Academic Article
• Cyclophilin and NS5A inhibitors, but not other anti-hepatitis C virus (HCV) agents, preclude HCV-mediated formation of double-membrane-vesicle viral factories  Academic Article
• Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site  Academic Article
• Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites  Academic Article
• Cyclostreptin derivatives specifically target cellular tubulin and further map the paclitaxel site  Academic Article
• Cytometric comparisons between circulating tumor cells from prostate cancer patients and the prostate-tumor-derived lncap cell line  Academic Article
• Cytotoxicity of a Ti(IV) compound is independent of serum proteins  Academic Article
• DNA methylation fingerprint of neuroblastoma reveals new biological and clinical insights  Academic Article
• DNA-based vaccines activate innate and adaptive antitumor immunity by engaging the nkg2d receptor  Academic Article
• DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cells  Academic Article
• Darwinian evolution of prions in cell culture  Academic Article
• Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint  Academic Article
• Deciphering the chromatin landscape induced around DNA double strand breaks  Academic Article
• Deep interactome profiling of membrane proteins by co-interacting protein identification technology  Academic Article
• Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function  Academic Article
• Defects in the acquisition of CD8 T cell effector function after priming with tumor or soluble antigen can be overcome by the addition of an OX40 agonist  Academic Article
• Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death  Academic Article
• Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors  Academic Article
• Deregulation of cyclin e in human cells interferes with prereplication complex assembly  Academic Article
• Derivation of a retinoid x receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-di(1h-indol-3-yl)methyl-4-trifluoromethylbenzene  Academic Article
• Design and synthesis of Hsp90 inhibitors: Exploring the SAR of Sansalvamide A derivatives  Academic Article
• Design and synthesis of alpha-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis  Academic Article
• Design, synthesis and biological evaluation of artemisinin derivatives containing fluorine atoms as anticancer agents  Academic Article
• Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors  Academic Article
• Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors  Academic Article
• Design, synthesis, and biological activity of substrate competitive SMYD2 inhibitors  Academic Article
• Design, synthesis, and biological evaluation of novel aminopyrimidinylisoindolines as AXL kinase inhibitors  Academic Article
• Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase  Academic Article
• Design, synthesis, and biological properties of highly potent epothilone b analogues  Academic Article
• Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of Jumonji domain-containing protein 2 histone demethylase inhibitors  Academic Article
• Detecting expression of 5T4 in CTCs and tumor samples from NSCLC patients  Academic Article
• Detection of human α-L-Fucosidase by a quinone methide-generating probe: enhanced activities in response to Helicobacter pylori Infection  Academic Article
• Detection of low molecular weight derivatives of cyclin e1 is a function of cyclin e1 protein levels in breast cancer  Academic Article
• Detection of miRNA in live cells by using templated RuII-catalyzed unmasking of a fluorophore  Academic Article
• Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors  Academic Article
• Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties  Academic Article
• Development of non-peptide ligands of growth factor receptor-bound protein 2-SRC homology 2 domain using molecular modeling and NMR spectroscopy  Academic Article
• Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB  Academic Article
• Development of trifunctional probes for glycoproteomic analysis  Academic Article
• Differential activation of Wnt-β-catenin pathway in triple negative breast cancer increases MMP7 in a PTEN dependent manner  Academic Article
• Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues  Academic Article
• Differential utilization of upstream augs in the beta-secretase mrna suggests that a shunting mechanism regulates translation  Academic Article
• Direct binding of a hepatitis c virus inhibitor to the viral capsid protein  Academic Article
• Direct interaction between TKS proteins and the N-terminal proline-rich region (PPR) of NoxA1 mediates Nox1-dependent ROS generation  Academic Article
• Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe  Academic Article
• Direct targeting of αvβ3 integrin on tumor cells with a monoclonal antibody, Abegrin™  Academic Article
• Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors  Academic Article
• Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system  Academic Article
• Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-m ethyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through structure-based drug design: a high affinity irreversible inhibitor targeting oncogenic EGFR mutants with selectivity over wild-type EGFR  Academic Article
• Discovery of TAK-960: an orally available small molecule inhibitor of polo-like kinase 1 (PLK1)  Academic Article
• Discovery of a noncovalent, mutant-selective epidermal growth factor receptor inhibitor  Academic Article
• Discovery of a potent and selective in vivo probe (GNE-272) for the bromodomain of CBP/EP300  Academic Article
• Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152)  Academic Article
• Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase  Academic Article
• Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer  Academic Article
• Discovery of a selective irreversible BMX inhibitor for prostate cancer  Academic Article
• Discovery of aminopiperidine-based Smac mimetics as IAP antagonists  Academic Article
• Discovery of matrix metalloproteases selective and activated peptide-doxorubicin prodrugs as anti-tumor agents  Academic Article
• Discovery of novel drugs for promising targets  Academic Article
• Discovery of potent and selective covalent inhibitors of JNK  Academic Article
• Discovery of small-molecule nonfluorescent inhibitors of fluorogen-fluorogen activating protein binding pair  Academic Article
• Disruption of the MYC transcriptional function by a small-molecule antagonist of MYC/MAX dimerization  Academic Article
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• Downregulation of tumor growth and invasion by redox-active nanoparticles  Academic Article
• Drug-inducible and simultaneous regulation of endogenous genes by single-chain nuclear receptor-based zinc-finger transcription factor gene switches  Academic Article
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• EZH2 is essential for glioblastoma cancer stem cell maintenance  Academic Article
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• Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies  Academic Article
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• Estrogen-related receptor alpha is a repressor of phosphoenolpyruvate carboxykinase gene transcription  Academic Article
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• Harnessing cyanine reactivity for optical imaging and drug delivery  Academic Article
• Hepatitis C virus (HCV) induces formation of stress granules whose proteins regulate HCV RNA replication and virus assembly and egress  Academic Article
• Hepatocyte nuclear factor-4-independent synthesis of coagulation factor vii in breast cancer cells and its inhibition by targeting selective histone acetyltransferases  Academic Article
• Heregulin-ErbB3-driven tumor growth persists in PI3 kinase mutant cancer cells  Academic Article
• Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells  Academic Article
• Hiers: Hierarchical scaffold clustering using topological chemical graphs  Academic Article
• Hif2 alpha-sp1 interaction mediates a deacetylation-dependent fvii-gene activation under hypoxic conditions in ovarian cancer cells  Academic Article
• High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array  Academic Article
• High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase  Academic Article
• High-yield isolation of extracellular vesicles using aqueous two-phase system  Academic Article
• Histone arg modifications and p53 regulate the expression of okl38, a mediator of apoptosis  Academic Article
• Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability  Academic Article
• Histone deacetylase inhibitors enhance lexaturnurnab-induced apoptosis via a p21(cip1)-dependent decrease in survivin levels  Academic Article
• Homologous recombination is a primary pathway to repair DNA double-strand breaks generated during DNA rereplication  Academic Article
• Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4  Academic Article
• Hrr25/CK1 delta-directed release of Ltv1 from pre-40S ribosomes is necessary for ribosome assembly and cell growth  Academic Article
• Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus  Academic Article
• Human embryonic stem cells have a unique epigenetic signature  Academic Article
• Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis  Academic Article
• Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease  Academic Article
• Hydroxyamidine inhibitors of indoleamine-2,3-dioxygenase potently suppress systemic tryptophan catabolism and the growth of IDO-expressing tumors  Academic Article
• Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker  Academic Article
• Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and par-2-mediated heparin-binding egf signaling in endothelial cells  Academic Article
• Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells  Academic Article
• IFITM proteins restrict antibody-dependent enhancement of dengue virus infection  Academic Article
• IGF1R-and ROR1-specific CAR T cells as a potential therapy for high risk sarcomas  Academic Article
• IMD-0354 targets breast cancer stem cells: a novel approach for an adjuvant to chemotherapy to prevent multidrug resistance in a murine model  Academic Article
• INPP4B suppresses prostate cancer cell invasion  Academic Article
• Identification and characterization of a novel estrogenic ligand actinopolymorphol a  Academic Article
• Identification and characterization of small molecule antagonists of pRb inactivation by viral oncoproteins  Academic Article
• Identification and characterization of small-molecule inducers of fetal hemoglobin  Academic Article
• Identification and characterization of the first small molecule inhibitor of MDMX  Academic Article
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• Identification and optimization of small molecule antagonists of vasoactive intestinal peptide receptor-1 (VIPR1)  Academic Article
• Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)  Academic Article
• Identification of TG100-115 as a new and potent TRPM7 kinase inhibitor, which suppresses breast cancer cell migration and invasion  Academic Article
• Identification of a novel Mcl-1 protein binding motif  Academic Article
• Identification of a novel drug lead that inhibits HCV infection and cell-to-cell transmission by targeting the HCV E2 glycoprotein  Academic Article
• Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway  Academic Article
• Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers  Academic Article
• Identification of alk as a major familial neuroblastoma predisposition gene  Academic Article
• Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)  Academic Article
• Identification of an EGFRvIII-JNK2-HGF/c-Met-signaling axis required for intercellular crosstalk and glioblastoma multiforme cell invasion  Academic Article
• Identification of an overabundant cholesterol precursor in hepatitis B virus replicating cells by untargeted lipid metabolite profiling  Academic Article
• Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases  Academic Article
• Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening  Academic Article
• Identification of kinectin as a novel Behçet's disease autoantigen  Academic Article
• Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility  Academic Article
• Identification of novel ROS inducers: quinone derivatives tethered to long hydrocarbon chains  Academic Article
• Identification of novel binding elements and gene targets for the homeodomain protein BARX2  Academic Article
• Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach  Academic Article
• Identification of small molecule activators of cryptochrome  Academic Article
• Identification of small-molecule inhibitors of the colorectal cancer oncogene Kruppel-like factor 5 expression by ultrahigh-throughput screening  Academic Article
• Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells  Academic Article
• Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1  Academic Article
• Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling  Academic Article
• Identification of tumor-associated antigens as diagnostic and predictive biomarkers in cancer  Academic Article
• IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions  Academic Article
• Imaging androgen receptor signaling with a radiotracer targeting free prostate-specific antigen  Academic Article
• Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery  Academic Article
• Imaging of tumor vascularization using fluorescence molecular tomography to monitor arginine deiminase treatment in melanoma  Academic Article
• Imaging tumor burden in the brain with 89-Zr-transferrin  Academic Article
• Immunologic effects of an orally available BRAFV600E inhibitor in BRAF wild-type murine models  Academic Article
• Impact of substituents in tumor uptake and fluorescence imaging ability of near-infrared cyanine-like dyes  Academic Article
• Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor  Academic Article
• Improving the TFold test for differential shotgun proteomics  Academic Article
• In cellulo protein labelling with Ru-conjugate for luminescence imaging and bioorthogonal photocatalysis  Academic Article
• In situ kinase profiling reveals functionally relevant properties of native kinases  Academic Article
• In vitro imaging and in vivo liver targeting with carbohydrate capped quantum dots  Academic Article
• In vivo brain GPCR signaling elucidated by phosphoproteomics  Academic Article
• In vivo cleaved CDCP1 promotes early tumor dissemination via complexing with activated beta1 integrin and induction of FAK/PI3K/Akt motility signaling  Academic Article
• In vivo efficacy of natural product-inspired irreversible kinase inhibitors  Academic Article
• In vivo modification of native carrier protein domains  Academic Article
• In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential  Academic Article
• In vivo selection for metastasis promoting genes in the mouse  Academic Article
• In vivo selection of combinatorial libraries and designed affinity maturation of polydactyl zinc finger transcription factors for icam-1 provides new insights into gene regulation  Academic Article
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• The butterfly effect in cancer: A single base mutation can remodel the cell  Academic Article
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• The cyclophilin inhibitor SCY-635 suppresses viral replication and induces endogenous interferons in patients with chronic HCV genotype 1 infection  Academic Article
• The death effector domains of caspase-8 induce terminal differentiation  Academic Article
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• The development of n-alpha-(2-carboxyl)benzoyl-n(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-f-amidine) and n-alpha-(2-carboxyl)benzoyl-n(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-cl-amidine) as second generation protein arginine deiminase (pad) inhibitors  Academic Article
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