subject area of
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- 68Ga-PSMA-11 PET imaging of response to androgen receptor inhibition: first human experience Academic Article
- A 3-dimensional extracellular matrix as a delivery system for the transplantation of glioma-targeting neural stem/progenitor cells Academic Article
- A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy Academic Article
- A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3β Academic Article
- A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles Academic Article
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- A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive clinical, metastatic, developmental, and metabolic characteristics Academic Article
- A cross-species analysis of a mouse model of breast cancer-specific osteolysis and human bone metastases using gene expression profiling Academic Article
- A curcumin derivative that inhibits vinyl carbamate-induced lung carcinogenesis via activation of the Nrf2 protective response Academic Article
- A dual color immunohistochemistry assay for measurement of cereblon in multiple myeloma patient samples Academic Article
- A fluopol-ABPP HTS assay to identify PAD inhibitors Academic Article
- A fundamental relationship between hydrophobic properties and biological activity for the duocarmycin class of DNA-alkylating antitumor drugs: hydrophobic-binding-driven bonding Academic Article
- A general approach for receptor and antibody-targeted detection of native proteins utilizing split-luciferase reassembly Academic Article
- A genetically encoded aza-Michael acceptor for covalent cross-linking of protein-receptor complexes Academic Article
- A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing Academic Article
- A genomic screen identifies TYRO3 as a MITF regulator in melanoma Academic Article
- A global map of lipid-binding proteins and their ligandability in cells Academic Article
- A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters Academic Article
- A large noncoding rna is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas Academic Article
- A lentiviral vector allowing physiologically regulated membrane-anchored and secreted antibody expression depending on B-cell maturation status Academic Article
- A monoclonal antibody to ADAM17 inhibits tumor growth by inhibiting EGFR and non-EGFR-Mediated Pathways Academic Article
- A multifunctional bispecific antibody protects against Pseudomonas aeruginosa Academic Article
- A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis Academic Article
- A novel DNA vaccine encoding pdgfr beta suppresses growth and dissemination of murine colon, lung and breast carcinoma Academic Article
- A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target Academic Article
- A novel achiral seco-amino-cyclopropylindoline (CI) analog of CC-1065 and the duocarmycins: design, synthesis and biological studies Academic Article
- A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells Academic Article
- A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties Academic Article
- A novel estrogen receptor α-associated protein alters receptor-deoxyribonucleic acid interactions and represses receptor-mediated transcription Academic Article
- A novel high-affinity human monoclonal antibody to mesothelin Academic Article
- A novel mode of intervention with serine protease activity: targeting zymogen activation Academic Article
- A novel neuroprotective agent with antioxidant and nitric oxide synthase inhibitory action Academic Article
- A novel, unusually efficacious duocarmycin carbamate prodrug that releases no residual byproduct Academic Article
- A peptide that antagonizes tcr-mediated reactions with both syngeneic and allogeneic agonists: Functional and structural aspects Academic Article
- A phosphoproteomic analysis of the ErbB2 receptor tyrosine kinase signaling pathways Academic Article
- A physical sciences network characterization of non-tumorigenic and metastatic cells Academic Article
- A platform for artificial intelligence based identification of the extravasation potential of cancer cells into the brain metastatic niche Academic Article
- A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis Academic Article
- A reversible and highly selective inhibitor of the proteasomal ubiquitin receptor rpn13 is toxic to multiple myeloma cells Academic Article
- A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors Academic Article
- A second fatty acid amide hydrolase with variable distribution among placental mammals Academic Article
- A selective estrogen receptor modulator for the treatment of hot flushes Academic Article
- A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells Academic Article
- A short n-terminal sequence of pten controls cytoplasmic localization and is required for suppression of cell growth Academic Article
- A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase Academic Article
- A small molecule inhibitor of α4 integrin-dependent cell migration Academic Article
- A small molecule inhibits deregulated NRF2 transcriptional activity in cancer Academic Article
- A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth Academic Article
- A small molecule modulates circadian rhythms through phosphorylation of the period protein Academic Article
- A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein Academic Article
- A small-molecule antagonist of the hedgehog signaling pathway Academic Article
- A stapled p53 helix overcomes HDMX-mediated suppression of p53 Academic Article
- A structure-guided approach to creating covalent FGFR inhibitors Academic Article
- A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors Academic Article
- A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity Academic Article
- A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy Academic Article
- A system-wide investigation of the dynamics of Wnt signaling reveals novel phases of transcriptional regulation Academic Article
- A two-hit mechanism for pre-mitotic arrest of cancer cell proliferation by a polyamide-alkylator conjugate Academic Article
- A unique class of duocarmycin and CC-1065 analogues subject to reductive activation Academic Article
- AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin Academic Article
- ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1 Academic Article
- ATP induces protein arginine deiminase 2-dependent citrullination in mast cells through the P2X7 purinergic receptor Academic Article
- ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A Academic Article
- Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness Academic Article
- Aberrant, persistent inclusion into lipid rafts limits the tumorigenic function of membrane type-1 matrix metalloproteinase in malignant cells Academic Article
- Abnormal tau induces cognitive impairment through two different mechanisms: synaptic dysfunction and neuronal loss Academic Article
- Absence of CTL responses to early viral antigens facilitates viral persistence Academic Article
- Activating transcription factor 4 increases chemotherapeutics resistance of human hepatocellular carcinoma Academic Article
- Activating transcription factor 4 promotes angiogenesis of breast cancer through enhanced macrophage recruitment Academic Article
- Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor vii Academic Article
- Activation of pro-uPA is critical for initial escape from the primary tumor and hematogenous dissemination of human carcinoma cells Academic Article
- Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer Academic Article
- Activation of tumor cell integrin alpha(v)beta(3) controls angiogenesis and metastatic growth in the brain Academic Article
- Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth Academic Article
- Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins Academic Article
- Activity-based protein profiling implicates urokinase activation as a key step in human fibrosarcoma intravasation Academic Article
- Activity-based protein profiling of oncogene-driven changes in metabolism reveals broad dysregulation of PAFAH1B2 and 1B3 in cancer Academic Article
- Activity-based protein profiling of protein arginine methyltransferase 1 Academic Article
- Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474 Academic Article
- Adeno-associated virus enhances wild-type and oncolytic adenovirus spread Academic Article
- Adenoviral-mediated, intratumor gene transfer of interleukin 23 induces a therapeutic antitumor response Academic Article
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- Adjuvant therapy with agonistic antibodies to CD134 (OX40) increases local control after surgical or radiation therapy of cancer in mice Academic Article
- Advantages and limitations of particle-mediated transfection (gene gun) in cancer immuno-gene therapy using IL-10, IL-12 or B7-1 in murine tumor models Academic Article
- Akt demoted in glioblastoma Academic Article
- Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation Academic Article
- Akt-mediated phosphorylation of argonaute 2 downregulates cleavage and upregulates translational repression of MicroRNA targets Academic Article
- Aldolase antibody activation of prodrugs of potent aldehyde-containing cytotoxics for selective chemotherapy Academic Article
- Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells Academic Article
- Allosteric control of ligand selectivity between estrogen receptors alpha and beta: Implications for other nuclear receptors Academic Article
- Allosteric inhibition of hypoxia inducible factor-2 with small molecules Academic Article
- Alteration of the bis-tetrahydrofuran core stereochemistries in asimicin can affect the cytotoxicity Academic Article
- Altered trafficking of FAS and subsequent resistance to FAS-mediated apoptosis occurs by a wild-type p53 independent mechanism in esophageal adenocarcinoma Academic Article
- Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase Academic Article
- Alternatively spliced tissue factor promotes breast cancer growth in a beta 1 integrin-dependent manner Academic Article
- Alzheimer's Aβ peptides containing an isostructural backbone mutation afford distinct aggregate morphologies but analogous cytotoxicity. Evidence for a common low-abundance toxic structure(s)? Academic Article
- An Mtb-human protein-protein interaction map identifies a switch between host antiviral and antibacterial responses Academic Article
- An activity-based imaging probe for the integral membrane hydrolase KIAA1363 Academic Article
- An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth Academic Article
- An anti-B cell maturation antigen bispecific antibody for multiple myeloma Academic Article
- An efficient chemical approach to bispecific antibodies and antibodies of high valency Academic Article
- An endophytic Neurospora sp. from Nothapodytes foetida producing camptothecin Academic Article
- An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling Academic Article
- An immunoglobulin Cκ-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system Academic Article
- An in vivo tagging method reveals that Ras undergoes sustained activation upon transglutaminase-mediated protein serotonylation Academic Article
- An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer Academic Article
- An integrated transcriptomic and meta-analysis of hepatoma cells reveals factors that influence susceptibility to HCV infection Academic Article
- Analysis of URI nuclear interaction with RPB5 and components of the R2TP/prefoldin-like complex Academic Article
- Analysis of cell-cell contact mediated by Ig superfamily cell adhesion molecules Academic Article
- Analysis of microRNAs expressions in chondrosarcoma Academic Article
- Androgen receptor splice variants determine taxane sensitivity in prostate cancer Academic Article
- Androgen receptor upregulation mediates radioresistance after ionizing radiation Academic Article
- Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor Academic Article
- Annotating STEAP1 regulation in prostate cancer with (89)Zr immuno-PET Academic Article
- Anti-inflammatory activity in vitro and in vivo of the protein farnesyltransferase inhibitor tipifarnib Academic Article
- Anti-lung cancer activity and inhibitory mechanisms of a novel Calothrixin A derivative Academic Article
- Anti-proliferative actions of a synthetic REV-ERBα/β agonist in breast cancer cells Academic Article
- Anti-tumor and immunomodulatory activity of resveratrol in vitro and its potential for combining with cancer immunotherapy Academic Article
- Antibody microarrays utilizing site-specific antibody-oligonucleotide conjugates Academic Article
- Antibody-dependent cell-mediated cytotoxicity effector-enhanced EphA2 agonist monoclonal antibody demonstrates potent activity against human tumors Academic Article
- Anticancer properties of distinct antimalarial drug classes Academic Article
- Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor Academic Article
- Antigen-specific cytotoxicity by invariant NKT cells in vivo is CD95/CD178-dependent and is correlated with antigenic potency Academic Article
- Antinuclear autoantibodies in prostate cancer: immunity to LEDGF/p75, a survival protein highly expressed in prostate tumors and cleaved during apoptosis Academic Article
- Antischistosomal versus antiandrogenic properties of aryl hydantoin Ro 13-3978 Academic Article
- Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase Academic Article
- Antitumor effects and mechanisms ofAZD4547on FGFR2-deregulated endometrial cancer cells Academic Article
- Apoptotic tumor cells induce il-27 release from human dcs to activate treg cells that express cd69 and attenuate cytotoxicity Academic Article
- Applying PET to broaden the diagnostic utility of the clinically validated CA19.9 serum biomarker for oncology Academic Article
- Apurinic/apyrimidinic endonuclease 1 alters estrogen receptor activity and estrogen-responsive gene expression Academic Article
- Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKK epsilon Academic Article
- Arresting cancer proliferation by small-molecule gene regulation Academic Article
- Arylsulfonamide kcn1 inhibits in vivo glioma growth and interferes with hif signaling by disrupting hif-1 alpha interaction with cofactors p300/cbp Academic Article
- Assessing compound binding to the Eg5 motor domain using a thermal shift assay Academic Article
- Assessing enzyme activities using stable isotope labeling and mass spectrometry Academic Article
- Assessment of therapeutic efficacy of liposomal nanoparticles mediated gene delivery by molecular imaging for cancer therapy Academic Article
- Association with the plasma membrane is sufficient for potentiating catalytic activity of regulators of G protein signaling (RGS) proteins of the R7 subfamily Academic Article
- Asymmetric synthesis and biological properties of uncialamycin and 26-epi-uncialamycin Academic Article
- Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase Academic Article
- Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells Academic Article
- Automated screening of microtubule growth dynamics identifies MARK2 as a regulator of leading edge microtubules downstream of Rac1 in migrating cells Academic Article
- Autophagy-regulated ROS from xanthine oxidase acts as an early effector for triggering late mitochondria-dependent apoptosis in cathepsin S-targeted tumor cells Academic Article
- Avidity of cd1d-ligand-receptor ternary complex contributes to t-helper 1 (th1) polarization and anticancer efficacy Academic Article
- Azaxanthene based selective glucocorticoid receptor modulators: design, synthesis, and pharmacological evaluation of (S)-4-(5-(1-((1,3,4-thiadiazol-2-yl)amino)-2-methyl-1-oxopropan-2-yl)-5H-chromeno[2,3-b]pyridin-2-yl)-2-fluoro-N,N-dimethylbenzamide (BMS-776532) and its methylene homologue (BMS-791826) Academic Article
- B-cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention Academic Article
- BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction Academic Article
- Background gene expression networks significantly enhance drug response prediction by transcriptional profiling Academic Article
- Benzazepinones and benzoxazepinones as antagonists of inhibitor of apoptosis proteins (IAPs) selective for the second baculovirus IAP repeat (BIR2) domain Academic Article
- Beta-lactam-based approach for the chemical programming of aldolase antibody 38c2 Academic Article
- Bidirectional transcription directs both transcriptional gene activation and suppression in human cells Academic Article
- Bifunctional electrophiles cross-link thioredoxins with redox relay partners in cells Academic Article
- Biobanking: an important resource for precision medicine in glioblastoma Academic Article
- Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1 Academic Article
- Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase Academic Article
- Biomimetic total synthesis of gambogin and rate acceleration of pericyclic reactions in aqueous media Academic Article
- Biomimetically inspired total synthesis and structure activity relationships of 1-o-methyllateriflorone. 6 pi electrocyclizations in organic synthesis Academic Article
- Biosynthesis of 14,15-hepoxilins in human l1236 Hodgkin lymphoma cells and eosinophils Academic Article
- Bipartite functions of the CREB co-activators selectively direct alternative splicing or transcriptional activation Academic Article
- Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors Academic Article
- Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors Academic Article
- Blocking lactate export by inhibiting the Myc target MCT1 disables glycolysis and glutathione synthesis Academic Article
- Bortezomib resistance in mantle cell lymphoma is associated with plasmacytic differentiation Academic Article
- Both scf(cdc4 alpha) and scf(cdc4 gamma) are required for cyclin e turnover in cell lines that do not overexpress cyclin e Academic Article
- Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1 Academic Article
- Breadth of neutralization and synergy of clinically relevant human monoclonal antibodies against HCV genotypes 1a, 1b, 2a, 2b, 2c, and 3a Academic Article
- Breaking the one antibody-one target axiom Academic Article
- Breast cancer cell lines grown in vivo: What goes in isn't always the same as what comes out Academic Article
- Broad anti-tumor activity of a small molecule that selectively targets the Warburg effect and lipogenesis Academic Article
- Brusatol overcomes chemoresistance through inhibition of protein translation Academic Article
- Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1 Academic Article
- Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax Academic Article
- CBP is a dosage-dependent regulator of nuclear factor-kappa B suppression by the estrogen receptor Academic Article
- CD200 expression on tumor cells suppresses antitumor immunity: new approaches to cancer immunotherapy Academic Article
- CDC25B mediates rapamycin-induced oncogenic responses in cancer cells Academic Article
- CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability Academic Article
- CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma Academic Article
- CEBPA-dependent HK3 and KLF5 expression in primary AML and during AML differentiation Academic Article
- CLEC5A (MDL-1) is a novel PU.1 transcriptional target during myeloid differentiation Academic Article
- CS1, a potential new therapeutic antibody target for the treatment of multiple myeloma Academic Article
- CXCR4 activation maintains a stem cell population in tamoxifen-resistant breast cancer cells through AhR signalling Academic Article
- Caged [(18)F]FDG glycosylamines for imaging acidic tumor microenvironments using positron emission tomography Academic Article
- Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4t1 murine breast cancer model Academic Article
- Cancer gene therapy using a novel secretable trimeric trail Academic Article
- Capturing changes in the brain microenvironment during initial steps of breast cancer brain metastasis Academic Article
- Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo Academic Article
- Cd22 is a recycling receptor that can shuttle cargo between the cell surface and endosomal compartments of b cells Academic Article
- Cell based screening of inhibitors of transthyretin aggregation Academic Article
- Cell growth inhibition and actin cytoskeleton disorganization induced by azaspiracid-1 structure-activity studies Academic Article
- Cell penetrating peptide amphiphile integrated liposomal systems for enhanced delivery of anticancer drugs to tumor cells Academic Article
- Cell surface proteomics identifies molecules functionally linked to tumor cell intravasation Academic Article
- Cell targeting with hybrid Qβ virus-like particles displaying epidermal growth factor Academic Article
- Cell, isoform, and environment factors shape gradients and modulate chemotaxis Academic Article
- Cell-specific susceptibility to prion strains is a property of the intact cell Academic Article
- Cellular cofactors affecting hepatitis C virus infection and replication Academic Article
- Ceramide triggers budding of exosome vesicles into multivesicular endosomes Academic Article
- Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays Academic Article
- Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR. Academic Article
- Characterization of a hypoxia-response element in the Epo locus of the pufferfish, Takifugu rubripes Academic Article
- Characterization of a side population of astrocytoma cells in response to temozolomide Academic Article
- Characterization of lassa virus cell entry inhibitors: Determination of the active enantiomer by asymmetric synthesis Academic Article
- Characterization of stem cell-like cancer cells in immune-competent mice Academic Article
- Characterization of the human protein S gene promoter: a possible role of transcription factors Sp1 and HNF3 in liver Academic Article
- Charcot-Marie-Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect Academic Article
- Chem-seq permits identification of genomic targets of drugs against androgen receptor regulation selected by functional phenotypic screens Academic Article
- Chemical adaptor immunotherapy: design, synthesis, and evaluation of novel integrin-targeting devices Academic Article
- Chemical generation of bispecific antibodies Academic Article
- Chemical proteomics identifies druggable vulnerabilities in a genetically defined cancer Academic Article
- Chemical synthesis and biological evaluation of palmerolide a analogues Academic Article
- Chemically programmed antibodies targeting multiple alpha(v) integrins and their effects on tumor-related functions in vitro Academic Article
- Chemically programmed bispecific antibody targeting legumain protease and avß3 integrin mediates strong antitumor effects Academic Article
- Chemistry and biology of diazonamide A: Second total synthesis and biological investigations Academic Article
- Chemo-resistant protein expression pattern of glioblastoma cells (A172) to perillyl alcohol Academic Article
- Chemoproteomic evaluation of target engagement by the cyclin-dependent kinase 4 and 6 inhibitor palbociclib correlates with cancer cell response Academic Article
- Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma Academic Article
- Chemotherapy-resistant human acute myeloid leukemia cells are not enriched for leukemic stem cells but require oxidative metabolism Academic Article
- Chick embryo chorioallantoic membrane model systems to study and visualize human tumor cell metastasis Academic Article
- Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription Academic Article
- Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3 Academic Article
- Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells Academic Article
- Chromosomal instability estimation based on next generation sequencing and single cell genome wide copy number variation analysis Academic Article
- Chronophin coordinates cell leading edge dynamics by controlling active cofilin levels Academic Article
- Cks overexpression enhances chemotherapeutic efficacy by overriding DNA damage checkpoints Academic Article
- Clathrate nanostructures for mass spectrometry Academic Article
- Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors Academic Article
- Cold stress-induced protein rbm3 binds 60s ribosomal subunits, alters rnicrorna levels, and enhances global protein synthesis Academic Article
- Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer Academic Article
- Combination of anti-HER3 antibody MM-121/SAR256212 and cetuximab inhibits tumor growth in preclinical models of head and neck squamous cell carcinoma Academic Article
- Combination therapy targeting both tumor-initiating and differentiated cell populations in prostate carcinoma Academic Article
- Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer Academic Article
- Comparative analysis of antitumor activity of CD40L, RANKL, and 4-1BBL in vivo following intratumoral administration of viral vectors or transduced dendritic cells Academic Article
- Comparative analysis of metastasis variants derived from human prostate carcinoma cells: roles in intravasation of VEGF-mediated angiogenesis and uPA-mediated invasion Academic Article
- Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues Academic Article
- Comparison of in vitro and in vivo approaches to studying brain colonization by breast cancer cells Academic Article
- Complete replication of hepatitis C virus in cell culture Academic Article
- Comprehensive mapping of histone modifications at DNA double-strand breaks deciphers repair pathway chromatin signatures Academic Article
- Comprehensive study of sansalvamide a derivatives and their structure-activity relationships against drug-resistant colon cancer cell lines Academic Article
- Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells Academic Article
- Conditional regulation of the human CYP4X1 and CYP4Z1 genes Academic Article
- Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate Academic Article
- Construction, affinity maturation, and biological characterization of an anti-tumor-associated glycoprotein-72 humanized antibody Academic Article
- Contributions of thrombin targets to tissue factor-dependent metastasis in hyperthrombotic mice Academic Article
- Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment Academic Article
- Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis Academic Article
- Coumarins hinged directly on benzimidazoles and their ribofuranosides to inhibit hepatitis C virus Academic Article
- Coupling of receptor conformation and ligand orientation determine graded activity Academic Article
- Covalent ligand discovery against druggable hotspots targeted by anti-cancer natural products Academic Article
- Crystal structure of the human n-myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor Academic Article
- Crystal structures of human HSP90 alpha-complexed with dihydroxyphenylpyrazoles Academic Article
- Cyclic marinopyrrole derivatives as disruptors of Mcl-1 and Bcl-x(L) binding to Bim Academic Article
- Cyclin E deregulation promotes loss of specific genomic regions Academic Article
- Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities Academic Article
- Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins Academic Article
- Cycloheximide and congeners as inhibitors of eukaryotic protein synthesis from endophytic actinomycetes streptomyces sps. Yim56132 and yim56141 Academic Article
- Cyclophilin and NS5A inhibitors, but not other anti-hepatitis C virus (HCV) agents, preclude HCV-mediated formation of double-membrane-vesicle viral factories Academic Article
- Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site Academic Article
- Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites Academic Article
- Cyclostreptin derivatives specifically target cellular tubulin and further map the paclitaxel site Academic Article
- Cytometric comparisons between circulating tumor cells from prostate cancer patients and the prostate-tumor-derived lncap cell line Academic Article
- Cytotoxicity of a Ti(IV) compound is independent of serum proteins Academic Article
- DNA methylation fingerprint of neuroblastoma reveals new biological and clinical insights Academic Article
- DNA-based vaccines activate innate and adaptive antitumor immunity by engaging the nkg2d receptor Academic Article
- DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cells Academic Article
- Darwinian evolution of prions in cell culture Academic Article
- Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint Academic Article
- Deciphering the chromatin landscape induced around DNA double strand breaks Academic Article
- Deep interactome profiling of membrane proteins by co-interacting protein identification technology Academic Article
- Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function Academic Article
- Defects in the acquisition of CD8 T cell effector function after priming with tumor or soluble antigen can be overcome by the addition of an OX40 agonist Academic Article
- Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death Academic Article
- Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors Academic Article
- Deregulation of cyclin e in human cells interferes with prereplication complex assembly Academic Article
- Derivation of a retinoid x receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-di(1h-indol-3-yl)methyl-4-trifluoromethylbenzene Academic Article
- Design and synthesis of Hsp90 inhibitors: Exploring the SAR of Sansalvamide A derivatives Academic Article
- Design and synthesis of alpha-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis Academic Article
- Design, synthesis and biological evaluation of artemisinin derivatives containing fluorine atoms as anticancer agents Academic Article
- Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors Academic Article
- Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors Academic Article
- Design, synthesis, and biological activity of substrate competitive SMYD2 inhibitors Academic Article
- Design, synthesis, and biological evaluation of novel aminopyrimidinylisoindolines as AXL kinase inhibitors Academic Article
- Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase Academic Article
- Design, synthesis, and biological properties of highly potent epothilone b analogues Academic Article
- Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of Jumonji domain-containing protein 2 histone demethylase inhibitors Academic Article
- Detecting expression of 5T4 in CTCs and tumor samples from NSCLC patients Academic Article
- Detection of human α-L-Fucosidase by a quinone methide-generating probe: enhanced activities in response to Helicobacter pylori Infection Academic Article
- Detection of low molecular weight derivatives of cyclin e1 is a function of cyclin e1 protein levels in breast cancer Academic Article
- Detection of miRNA in live cells by using templated RuII-catalyzed unmasking of a fluorophore Academic Article
- Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors Academic Article
- Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties Academic Article
- Development of non-peptide ligands of growth factor receptor-bound protein 2-SRC homology 2 domain using molecular modeling and NMR spectroscopy Academic Article
- Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB Academic Article
- Development of trifunctional probes for glycoproteomic analysis Academic Article
- Differential activation of Wnt-β-catenin pathway in triple negative breast cancer increases MMP7 in a PTEN dependent manner Academic Article
- Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues Academic Article
- Differential utilization of upstream augs in the beta-secretase mrna suggests that a shunting mechanism regulates translation Academic Article
- Direct binding of a hepatitis c virus inhibitor to the viral capsid protein Academic Article
- Direct interaction between TKS proteins and the N-terminal proline-rich region (PPR) of NoxA1 mediates Nox1-dependent ROS generation Academic Article
- Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe Academic Article
- Direct targeting of αvβ3 integrin on tumor cells with a monoclonal antibody, Abegrin™ Academic Article
- Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors Academic Article
- Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system Academic Article
- Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-m ethyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through structure-based drug design: a high affinity irreversible inhibitor targeting oncogenic EGFR mutants with selectivity over wild-type EGFR Academic Article
- Discovery of TAK-960: an orally available small molecule inhibitor of polo-like kinase 1 (PLK1) Academic Article
- Discovery of a noncovalent, mutant-selective epidermal growth factor receptor inhibitor Academic Article
- Discovery of a potent and selective in vivo probe (GNE-272) for the bromodomain of CBP/EP300 Academic Article
- Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152) Academic Article
- Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase Academic Article
- Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer Academic Article
- Discovery of a selective irreversible BMX inhibitor for prostate cancer Academic Article
- Discovery of aminopiperidine-based Smac mimetics as IAP antagonists Academic Article
- Discovery of matrix metalloproteases selective and activated peptide-doxorubicin prodrugs as anti-tumor agents Academic Article
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