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Thiazolidinediones

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  • A combined ligand- and structure-based virtual screening protocol identifies submicromolar PPAR gamma partial agonists  Academic Article
  • A dominant-negative peroxisome proliferator-activated receptor gamma (ppar gamma) mutant is a constitutive repressor and inhibits ppar gamma-mediated adipogenesis  Academic Article
  • A novel method for analysis of nuclear receptor function at natural promoters: Peroxisome proliferator-activated receptor gamma agonist actions on ap2 gene expression detected using branched DNA messenger rna quantitation  Academic Article
  • Activators of the nuclear receptor ppar gamma enhance colon polyp formation  Academic Article
  • Analysis of human cytochrome P4502C8 substrate specificity using a substrate pharmacophore and site-directed mutants  Academic Article
  • Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPAR gamma by Cdk5  Academic Article
  • Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation  Academic Article
  • Cancer-derived mutations in the regulatory subunit p85α of phosphoinositide 3-kinase function through the catalytic subunit p110α  Academic Article
  • Determinants of cytochrome P4502C8 substrate binding - structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid  Academic Article
  • Discovery, synthesis and sar analysis of novel selective small molecule s1p(4)-r agonists based on a (2z,5z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-o ne chemotype  Academic Article
  • Down-regulation of the expression of the obese gene by an antidiabetic thiazolidinedione in Zucker diabetic fatty rats and db/db mice  Academic Article
  • Effect of thiazolidinediones on expression of ucp2 and adipocyte markers in human paz6 adipocytes  Academic Article
  • High-throughput kinase profiling: A more efficient approach toward the discovery of new kinase inhibitors  Academic Article
  • Hydrogen/deuterium-exchange (H/D-Ex) of PPAR gamma LBD in the presence of various modulators  Academic Article
  • Induction of plasminogen activator inhibitor 1 gene expression in adipocytes by thiazolidinediones  Academic Article
  • Interventional cardiology - peroxisome proliferator-activated receptor gamma agonists for the prevention of adverse events following percutaneous coronary revascularization - results of the ppar study  Academic Article
  • L-764406 is a partial agonist of human peroxisome proliferator-activated receptor gamma. The role of Cys313 in ligand binding  Academic Article
  • Ligand and receptor dynamics contribute to the mechanism of graded PPAR gamma agonism  Academic Article
  • Lysophosphatidic acid inhibits adipocyte differentiation via lysophosphatidic acid 1 receptor-dependent down-regulation of peroxisome proliferator-activated receptor gamma 2  Academic Article
  • Nuclear receptors have distinct affinities for coactivators: characterization by fluorescence resonance energy transfer  Academic Article
  • Osteopontin is required for the early onset of high fat diet-induced insulin resistance in mice  Academic Article
  • PPARG post-translational modifications regulate bone formation and bone resorption  Academic Article
  • Percutaneous coronary intervention in diabetic patients with non-st-segment elevation acute coronary syndromes  Academic Article
  • Peroxisome proliferator-activated receptor (ppar) gamma coactivator-1 recruitment regulates ppar subtype specificity  Academic Article
  • Peroxisome proliferator-activated receptor gamma down-regulates receptor for advanced glycation end products and inhibits smooth muscle cell proliferation in a diabetic and nondiabetic rat carotid artery injury model  Academic Article
  • Potentiation of insulin stimulation of phosphatidylinositol 3-kinase by thiazolidinedione-derived antidiabetic agents in Chinese hamster ovary cells expressing human insulin receptors and L6 myotubes  Academic Article
  • Ppar gamma activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes  Academic Article
  • Regulation of adipogenesis by natural and synthetic REV-ERB ligands  Academic Article
  • Rosiglitazone-induced mitochondrial biogenesis in white adipose tissue is independent of peroxisome proliferator-activated receptor gamma coactivator-1 alpha  Academic Article
  • Targeting orphan nuclear receptors for treatment of metabolic diseases and autoimmunity  Academic Article

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