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• Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1  Academic Article
• Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1  Academic Article
• Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3  Academic Article
• Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1  Academic Article
• Activated protein C variants with normal cytoprotective but reduced anticoagulant activity  Academic Article
• Activated protein c blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective  Academic Article
• Activated protein c signals through the thrombin receptor par1 in endothelial cells  Academic Article
• Activated protein c-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin  Academic Article
• Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor vii  Academic Article
• Activation of endothelial cell protease activated receptor 1 by the protein c pathway  Academic Article
• Apolipoprotein E receptor 2 mediates activated protein C-induced endothelial Akt activation and endothelial barrier stabilization  Academic Article
• Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46  Academic Article
• Cell painting with an engineered EPCR to augment the protein C system  Academic Article
• Coagulation factor xa cleaves protease-activated receptor-1 and mediates signaling dependent on binding to the endothelial protein c receptor  Academic Article
• Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition  Academic Article
• Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes  Academic Article
• Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation  Academic Article
• Endothelial barrier protection by activated protein c through par1-dependent sphingosine 1-phosphate receptor-1 crossactivation  Academic Article
• Factor xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1  Academic Article
• Failure to validate association of gene polymorphisms in EPCR, PAR-1, FSAP and protein S Tokushima with venous thromboembolism among Californians of European ancestry  Academic Article
• G protein-coupled receptor Ca2+-linked mlitochondrial reactive oxygen species are essential for endothelial/leukocyte adherence  Academic Article
• Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1  Academic Article
• Inflammation, obesity, and thrombosis  Academic Article
• Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor  Academic Article
• Inhibition of tissue factor signaling suppresses tumor growth  Academic Article
• Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway  Academic Article
• Molecular regulation of blood clotting in tumor biology  Academic Article
• Neutrophil activation by the tissue factor/factor viia/par2 axis mediates fetal death in a mouse model of anti phospholipid syndrome  Academic Article
• Noncanonical PAR3 activation by factor Xa identifies a novel pathway for Tie2 activation and stabilization of vascular integrity  Academic Article
• Orchestration of coagulation protease signaling by tissue factor  Academic Article
• PAR1 regulation of CXCL1 expression and neutrophil recruitment to the lung in mice infected with influenza A virus  Academic Article
• PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells  Academic Article
• Plasmin-induced migration requires signaling through protease-activated receptor 1 and integrin alpha(9)beta(1)  Academic Article
• Plasminogen inhibits TNF alpha-induced apoptosis in monocytes  Academic Article
• Protease-activated receptor (par) 2, but not par1, signaling promotes the development of mammary adenocarcinoma in polyoma middle t mice  Academic Article
• Protease-activated receptor (par)1 alters bioelectric properties of distal lung epithelia without compromising barrier function  Academic Article
• Protease-activated receptor-1 cleaved at r46 mediates cytoprotective effects  Academic Article
• Protease-activated receptor-1 modulates hippocampal memory formation and synaptic plasticity  Academic Article
• Protease-activated receptor-1 signaling by activated protein c in cytokine-perturbed endothelial cells is distinct from thrombin signaling  Academic Article
• Protease-activated receptors (par1 and par2) contribute to tumor cell motility and metastasis  Academic Article
• Protease-activated receptors-1 and-2 can mediate endothelial barrier protection: Role in factor xa signaling  Academic Article
• Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1  Academic Article
• Protein C system defects inflicted by the malaria parasite protein PfEMP1 can be overcome by a soluble EPCR variant  Academic Article
• Regulation of tissue factor-induced signaling by endogenous and recombinant tissue factor pathway inhibitor  Academic Article
• Role of protease activated receptor 1 and 2 signaling in hypoxia-induced angiogenesis  Academic Article
• The cytoprotective protein C pathway  Academic Article
• The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors  Academic Article
• Thrombin affects eosinophil migration via protease-activated receptor-1  Academic Article
• Tissue factor and par1 promote microbiota-induced intestinal vascular remodelling  Academic Article
• Tissue factor and protease-activated receptor signaling in cancer  Academic Article
• Tissue factor-dependent signaling in tumor biology  Academic Article
• Tumor MMP-1 activates endothelial PAR1 to facilitate vascular intravasation and metastatic dissemination  Academic Article
• Unique pathway of thrombin-induced platelet aggregation mediated by glycoprotein Ib  Academic Article