subject area of

• A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition  Academic Article
• A single amino acid change in the binding pocket alters specificity of an anti-integrin antibody AP7.4 as revealed by its crystal structure  Academic Article
• Antibody modeling assessment II. Structures and models  Academic Article
• Antigen-driven selection of tcr in vivo: Related tcr alpha-chains pair with diverse tcr beta-chains  Academic Article
• Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics  Academic Article
• Computational design of protein antigens that interact with the CDR H3 loop of HIV broadly neutralizing antibody 2F5  Academic Article
• Construction, affinity maturation, and biological characterization of an anti-tumor-associated glycoprotein-72 humanized antibody  Academic Article
• Converting stem cells to dendritic cells by agonist antibodies from unbiased morphogenic selections  Academic Article
• Cross-neutralization of influenza a viruses mediated by a single antibody loop  Academic Article
• Crystal structure determination of anti-DNA Fab A52  Academic Article
• Crystal structure of PG16 and chimeric dissection with somatically related PG9: structure-function analysis of two quaternary-specific antibodies that effectively neutralize HIV-1  Academic Article
• Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design  Academic Article
• Crystal structure of a shark single-domain antibody v region in complex with lysozyme  Academic Article
• Crystal structure of an isolated V(alpha) domain of the 2C T-cell receptor  Academic Article
• Crystal structure of mouse cd1d bound to the self ligand phosphatidylcholine: A molecular basis for nkt cell activation  Academic Article
• Development of a high-throughput screen for protein catalysts: application to the directed evolution of antibody aldolases  Academic Article
• Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies  Academic Article
• Ectopic B-cell clusters that infiltrate transplanted human kidneys are clonal  Academic Article
• Emergence of a type ii collagen-specific helper t cell response  Academic Article
• Evolution of antigen-specific t cell receptors in vivo: Preimmune and antigen-driven selection of preferred complementarity-determining region 3 (cdr3) motifs  Academic Article
• Fine specificity of tcr complementarity-determining region residues and lipid antigen hydrophilic moieties in the recognition of a cd1-lipid complex  Academic Article
• Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing  Academic Article
• Frequency and genetic characterization of V(DD)J recombinants in the human peripheral blood antibody repertoire  Academic Article
• Functional antibody CDR3 fusion proteins with enhanced pharmacological properties  Academic Article
• Functional human antibody CDR fusions as long-acting therapeutic endocrine agonists  Academic Article
• HIV envelope glycoform heterogeneity and localized diversity govern the initiation and maturation of a V2 apex broadly neutralizing antibody lineage  Academic Article
• HTLV-I env protein acts as a major antigen in patients with HTLV-I-associated arthropathy  Academic Article
• Human peripheral blood antibodies with long HCDR3s are established primarily at original recombination using a limited subset of germline genes  Academic Article
• Identification and characterization of single chain anti-cocaine catalytic antibodies  Academic Article
• Integrin α(IIb)β(3)-specific synthetic human monoclonal antibodies and HCDR3 peptides that potently inhibit platelet aggregation  Academic Article
• Malachite green mediates homodimerization of antibody VL domains to form a fluorescent ternary complex with singular symmetric interfaces  Academic Article
• Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120  Academic Article
• Nucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies  Academic Article
• Oligoclonality and innate-like features in the TCR repertoire of type II NKT cells reactive to a beta-linked self-glycolipid  Academic Article
• Paucity of V-D-D-J rearrangements and V-H replacement events in lupus prone and nonautoimmune TdT(-/-) and TdT(+/+) mice  Academic Article
• Prevention of cell death by antibodies selected from intracellular combinatorial libraries  Academic Article
• Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen  Academic Article
• Rational design of CXCR4 specific antibodies with elongated CDRs  Academic Article
• Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth  Academic Article
• Relationship between antibody 2f5 neutralization of hiv-1 and hydrophobicity of its heavy chain third complementarity-determining region  Academic Article
• Reshaping antibody diversity  Academic Article
• Structural basis for amide hydrolysis catalyzed by the 43C9 antibody  Academic Article
• Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors  Academic Article
• Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2f5 in complex with its gp41 epitope  Academic Article
• T cell populations in the pancreatic lymph node naturally and consistently expand and contract in NOD mice as disease progresses  Academic Article
• Terminal deoxynucleotidyl transferase deficiency decreases autoimmune disease in MRL-Fas(lpr) mice  Academic Article
• The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies  Academic Article
• The long third complementarity-determining region of the heavy chain is important in the activity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2f5  Academic Article
• The role of HLA-DQ8 beta 57 polymorphism in the anti-gluten T-cell response in coeliac disease  Academic Article
• Tissue-specific expressed antibody variable gene repertoires  Academic Article
• Towards the generation of artificial O(6)-alkylguanine-DNA alkyltransferases: in vitro selection of antibodies with reactive cysteine residues  Academic Article
• Unusual germline DSP2 gene accounts for all apparent V-D-D-J rearrangements in newborn, but not adult, MRL mice  Academic Article