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• 4-Aminoindazolyl-dihydrofuro 3,4-d pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase  Academic Article
• 5-aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor alpha-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated protein kinase-independent  Academic Article
• A chemical, genetic, and structural analysis of the nuclear bile acid receptor fxr  Academic Article
• A genetically humanized mouse model for hepatitis C virus infection  Academic Article
• A novel approach for monitoring extracellular acidification rates: based on bead injection spectrophotometry and the lab-on-valve system  Academic Article
• Aberrant expression of fetal RNA-binding protein p62 in liver cancer and liver cirrhosis  Academic Article
• Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in mice  Academic Article
• Aging accelerates endotoxin-induced thrombosis: increased responses of plasminogen activator inhibitor-1 and lipopolysaccharide signaling with aging  Academic Article
• Alisporivir inhibition of hepatocyte cyclophilins reduces HBV replication and hepatitis B surface antigen production  Academic Article
• Antiviral stilbene 1,2-diamines prevent initiation of hepatitis C virus RNA replication at the outset of infection  Academic Article
• Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: Involvement of regulatory T cells  Academic Article
• Bioactivation of the epidermal growth factor receptor inhibitor gefitinib: Implications for pulmonary and hepatic toxicities  Academic Article
• Bipartite functions of the CREB co-activators selectively direct alternative splicing or transcriptional activation  Academic Article
• Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of hfe, transferrin receptor 2 (tfr2), and il-6  Academic Article
• Broadly neutralizing antibodies abrogate established hepatitis C virus infection  Academic Article
• Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity  Academic Article
• Cell co-culture patterning using aqueous two-phase systems  Academic Article
• Cell-autonomous circadian clock of hepatocytes drives rhythms in transcription and polyamine synthesis  Academic Article
• Cell-autonomous hepatic circadian clock regulates polyamine synthesis  Academic Article
• Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages  Academic Article
• Characterization of T-5 N-oxide formation as the first highly selective measure of CYP3A5 activity  Academic Article
• Comment on "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA"  Academic Article
• Cyclophilin A-independent recruitment of NS5A and NS5B into hepatitis C virus replication complexes  Academic Article
• Cytokine-sensitive replication of hepatitis B virus in immortalized mouse hepatocyte cultures  Academic Article
• Development of a liver-targeted siRNA delivery platform with a broad therapeutic window utilizing biodegradable polypeptide-based polymer conjugates  Academic Article
• Differential effects of phthalates on the testis and the liver  Academic Article
• Dimerization-driven interaction of hepatitis c virus core protein with ns3 helicase  Academic Article
• Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)  Academic Article
• Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2  Academic Article
• Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido )nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus  Academic Article
• Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia  Academic Article
• Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: A bench-to-bedside case study on tissue selective drug distribution  Academic Article
• Dose-response in a high density three-dimensional liver device with real-time bioenergetic and metabolic flux quantification  Academic Article
• Effects of acetylbergenin against d-galactosamine-induced hepatotoxicity in rats  Academic Article
• Effects of foxo4 overexpression on cholesterol biosynthesis, triacylglycerol accumulation, and glucose uptake  Academic Article
• Estrogen-related receptor alpha is a repressor of phosphoenolpyruvate carboxykinase gene transcription  Academic Article
• Evaluation of aldehyde dehydrogenase 1 promoter polymorphisms identified in human populations  Academic Article
• Exposure of plasmodium sporozoites to the intracellular concentration of potassium enhances infectivity and reduces cell passage activity  Academic Article
• Fatty acid amide hydrolase determines anandamide-induced cell death in the liver  Academic Article
• Genistein, resveratrol, and 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside induce cytochrome P450 4F2 expression through an AMP-activated protein kinase-dependent pathway  Academic Article
• Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues  Academic Article
• Hepatic glucose sensing via the CREB coactivator CRTC2  Academic Article
• Hepatocyte nuclear factor-4-independent synthesis of coagulation factor vii in breast cancer cells and its inhibition by targeting selective histone acetyltransferases  Academic Article
• Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication  Academic Article
• Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment  Academic Article
• Hybrid periportal hepatocytes regenerate the injured liver without giving rise to cancer  Academic Article
• IKK beta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis  Academic Article
• Identification of pyrrolo[2,1-f][1,2,4] triazine-based inhibitors of Met kinase  Academic Article
• Identification of small molecule activators of cryptochrome  Academic Article
• Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling  Academic Article
• Ifit1 protects against lipopolysaccharide and D-galactosamine-induced fatal hepatitis by inhibiting activation of the JNK Pathway  Academic Article
• Immune suppression uncovers endogenous cytopathic effects of the hepatitis B virus  Academic Article
• Immunosurveillance of the liver by intravascular effector CD8(+) T cells  Academic Article
• In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance  Academic Article
• In vivo cleavage of alpha 2,6-sialyltransferase by alzheimer beta-secretase  Academic Article
• Induced pluripotent stem cell modeling of multisystemic, hereditary transthyretin amyloidosis  Academic Article
• Interferon modulation of cellular microRNAs as an antiviral mechanism  Academic Article
• Interleukin-6-induced plasminogen gene expression in murine hepatocytes is mediated by transcription factor CCAAT/enhancer binding protein beta (C/EBP beta)  Academic Article
• Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis  Academic Article
• Lack of Protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis  Academic Article
• Limited hepatitis B virus replication space in the chronically hepatitis C virus-infected liver  Academic Article
• Liver-expressed Igκ superantigen induces tolerance of polyclonal B cells by clonal deletion not κ to λ receptor editing  Academic Article
• Localization of regulatory elements mediating constitutive and cytokine-stimulated plasminogen gene expression  Academic Article
• Mechanisms and consequences of ebolavirus-induced lymphocyte apoptosis  Academic Article
• Metformin inhibits hepatic mTORC1 signaling via dose-dependent mechanisms involving AMPK and the TSC complex  Academic Article
• Mitochondrial clearance is regulated by atg7-dependent and -independent mechanisms during reticulocyte maturation  Academic Article
• Modulation of glucokinase by glucose, small-molecule activator and glucokinase regulatory protein: steady-state kinetic and cell-based analysis  Academic Article
• Mouse liver repopulation with hepatocytes generated from human fibroblasts  Academic Article
• Mouse liver-specific CD8(+) T-cells encounter their cognate antigen and acquire capacity to destroy target hepatocytes  Academic Article
• Multi-organ iron overload in an african-american man with alas2 r452s and slc40a1 r561g  Academic Article
• Mutation in fucose synthesis gene of Klebsiella pneumoniae affects capsule composition and virulence in mice  Academic Article
• N-acylthiadiazolines, a new class of liver x receptor agonists with selectivity for lxr beta  Academic Article
• NF-kB inhibition delays DNA damage-induced senescence and aging in mice  Academic Article
• New ws9326a congeners from streptomyces sp 9078 inhibiting brugia malayi asparaginyl-trna synthetase  Academic Article
• Novel PEI/poly-γ-gutamic acid nanoparticles for high efficient siRNA and plasmid DNA co-delivery  Academic Article
• Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1  Academic Article
• Novel endosomolytic poly(amido amine) polymer conjugates for systemic delivery of siRNA to hepatocytes in rodents and nonhuman primates  Academic Article
• Peptide inhibitors of hepatitis c virus core oligomerization and virus production  Academic Article
• Persistent hepatitis C virus infection in vitro: Coevolution of virus and host  Academic Article
• Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection  Academic Article
• Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite  Academic Article
• Production of infectious hepatitis C virus by well-differentiated, growth-arrested human hepatoma-derived cells  Academic Article
• Profiling of MicroRNA Targets Using Activity-Based Protein Profiling: Linking Enzyme Activity to MicroRNA-185 Function  Academic Article
• Quantitative inference of cellular parameters from microfluidic cell culture systems  Academic Article
• RagA, but not RagB, is essential for embryonic development and adult mice  Academic Article
• Real-time monitoring of lactate extrusion and glucose consumption of cultured cells using a lab-on-valve system  Academic Article
• Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling  Academic Article
• Regulation of carbohydrate metabolism by the farnesoid x receptor  Academic Article
• Regulation of hepcidin transcription by interleukin-1 and interleukin-6  Academic Article
• Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin  Academic Article
• Regulation of pyruvate dehydrogenase kinase expression by the farnesoid x receptor  Academic Article
• Replication of a hepatitis C virus replicon clone in mouse cells  Academic Article
• Reprogramming fibroblasts toward cardiomyocytes, neural stem cells and hepatocytes by cell activation and signaling-directed lineage conversion  Academic Article
• SERBP1 Is a component of the liver receptor homologue-1 transcriptional complex  Academic Article
• Searching for interferon-induced genes that inhibit hepatitis B virus replication in transgenic mouse hepatocytes  Academic Article
• Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study  Academic Article
• Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity  Academic Article
• Simultaneous detection of hepatitis C virus and interferon stimulated gene expression in infected human liver  Academic Article
• Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept  Academic Article
• Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2  Academic Article
• Stereospecific reduction of a potent kinesin spindle protein (KSP) inhibitor in human tissues  Academic Article
• Structure-Activity Relationship and Biological Investigation of SR18292 (16), a Suppressor of Glucagon-Induced Glucose Production  Academic Article
• Substituted Pyrazoles as hepatoselective HMG-CoA reductase inhibitors: Discovery of (3R,5R)-7-[2-(4-Fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)- 2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia  Academic Article
• Suppression of host p53 is critical for Plasmodium liver-stage infection  Academic Article
• Suppression of the hepcidin-encoding gene hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/tmprss6  Academic Article
• Targeted delivery of LXR Agonist Using a site-specific antibody drug conjugate  Academic Article
• Temporal orchestration of circadian autophagy rhythm by C/EBPβ  Academic Article
• The E3 ubiquitin ligase itch couples JNK activation to TNF alpha-induced cell death by inducing c-FLIP(L) turnover  Academic Article
• The contraction phase of virus-specific cd8(+) t cells is unaffected by a pan-caspase inhibitor  Academic Article
• The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats  Academic Article
• The il-6- and lipopolysaccharide-induced transcription of hepcidin in hfe-, transferrin receptor 2-, and beta(2)-microglobulin-deficient hepatocytes  Academic Article
• The isomerase active site of cyclophilin A is critical for hepatitis C virus replication  Academic Article
• The pore-forming toxin listeriolysin O mediates a novel entry pathway of L. monocytogenes into human hepatocytes  Academic Article
• The size of the viral inoculum contributes to the outcome of hepatitis B virus infection  Academic Article
• Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase  Academic Article
• Virion-independent transfer of replication-competent hepatitis C virus RNA between permissive cells  Academic Article