subject area of
- 4-Aminoindazolyl-dihydrofuro 3,4-d pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase Academic Article
- 5-aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor alpha-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated protein kinase-independent Academic Article
- A chemical, genetic, and structural analysis of the nuclear bile acid receptor fxr Academic Article
- A genetically humanized mouse model for hepatitis C virus infection Academic Article
- A novel approach for monitoring extracellular acidification rates: based on bead injection spectrophotometry and the lab-on-valve system Academic Article
- Aberrant expression of fetal RNA-binding protein p62 in liver cancer and liver cirrhosis Academic Article
- Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in mice Academic Article
- Aging accelerates endotoxin-induced thrombosis: increased responses of plasminogen activator inhibitor-1 and lipopolysaccharide signaling with aging Academic Article
- Alisporivir inhibition of hepatocyte cyclophilins reduces HBV replication and hepatitis B surface antigen production Academic Article
- Antiviral stilbene 1,2-diamines prevent initiation of hepatitis C virus RNA replication at the outset of infection Academic Article
- Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: Involvement of regulatory T cells Academic Article
- Bioactivation of the epidermal growth factor receptor inhibitor gefitinib: Implications for pulmonary and hepatic toxicities Academic Article
- Bipartite functions of the CREB co-activators selectively direct alternative splicing or transcriptional activation Academic Article
- Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of hfe, transferrin receptor 2 (tfr2), and il-6 Academic Article
- Broadly neutralizing antibodies abrogate established hepatitis C virus infection Academic Article
- Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity Academic Article
- Cell co-culture patterning using aqueous two-phase systems Academic Article
- Cell-autonomous circadian clock of hepatocytes drives rhythms in transcription and polyamine synthesis Academic Article
- Cell-autonomous hepatic circadian clock regulates polyamine synthesis Academic Article
- Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages Academic Article
- Characterization of T-5 N-oxide formation as the first highly selective measure of CYP3A5 activity Academic Article
- Comment on "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA" Academic Article
- Cyclophilin A-independent recruitment of NS5A and NS5B into hepatitis C virus replication complexes Academic Article
- Cytokine-sensitive replication of hepatitis B virus in immortalized mouse hepatocyte cultures Academic Article
- Development of a liver-targeted siRNA delivery platform with a broad therapeutic window utilizing biodegradable polypeptide-based polymer conjugates Academic Article
- Differential effects of phthalates on the testis and the liver Academic Article
- Dimerization-driven interaction of hepatitis c virus core protein with ns3 helicase Academic Article
- Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2) Academic Article
- Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2 Academic Article
- Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido )nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus Academic Article
- Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia Academic Article
- Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: A bench-to-bedside case study on tissue selective drug distribution Academic Article
- Dose-response in a high density three-dimensional liver device with real-time bioenergetic and metabolic flux quantification Academic Article
- Effects of acetylbergenin against d-galactosamine-induced hepatotoxicity in rats Academic Article
- Effects of foxo4 overexpression on cholesterol biosynthesis, triacylglycerol accumulation, and glucose uptake Academic Article
- Estrogen-related receptor alpha is a repressor of phosphoenolpyruvate carboxykinase gene transcription Academic Article
- Evaluation of aldehyde dehydrogenase 1 promoter polymorphisms identified in human populations Academic Article
- Exposure of plasmodium sporozoites to the intracellular concentration of potassium enhances infectivity and reduces cell passage activity Academic Article
- Fatty acid amide hydrolase determines anandamide-induced cell death in the liver Academic Article
- Genistein, resveratrol, and 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside induce cytochrome P450 4F2 expression through an AMP-activated protein kinase-dependent pathway Academic Article
- Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues Academic Article
- Hepatic glucose sensing via the CREB coactivator CRTC2 Academic Article
- Hepatocyte nuclear factor-4-independent synthesis of coagulation factor vii in breast cancer cells and its inhibition by targeting selective histone acetyltransferases Academic Article
- Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication Academic Article
- Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment Academic Article
- Hybrid periportal hepatocytes regenerate the injured liver without giving rise to cancer Academic Article
- IKK beta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis Academic Article
- Identification of pyrrolo[2,1-f][1,2,4] triazine-based inhibitors of Met kinase Academic Article
- Identification of small molecule activators of cryptochrome Academic Article
- Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling Academic Article
- Ifit1 protects against lipopolysaccharide and D-galactosamine-induced fatal hepatitis by inhibiting activation of the JNK Pathway Academic Article
- Immune suppression uncovers endogenous cytopathic effects of the hepatitis B virus Academic Article
- Immunosurveillance of the liver by intravascular effector CD8(+) T cells Academic Article
- In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance Academic Article
- In vivo cleavage of alpha 2,6-sialyltransferase by alzheimer beta-secretase Academic Article
- Induced pluripotent stem cell modeling of multisystemic, hereditary transthyretin amyloidosis Academic Article
- Interferon modulation of cellular microRNAs as an antiviral mechanism Academic Article
- Interleukin-6-induced plasminogen gene expression in murine hepatocytes is mediated by transcription factor CCAAT/enhancer binding protein beta (C/EBP beta) Academic Article
- Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis Academic Article
- Lack of Protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis Academic Article
- Limited hepatitis B virus replication space in the chronically hepatitis C virus-infected liver Academic Article
- Liver-expressed Igκ superantigen induces tolerance of polyclonal B cells by clonal deletion not κ to λ receptor editing Academic Article
- Localization of regulatory elements mediating constitutive and cytokine-stimulated plasminogen gene expression Academic Article
- Mechanisms and consequences of ebolavirus-induced lymphocyte apoptosis Academic Article
- Metformin inhibits hepatic mTORC1 signaling via dose-dependent mechanisms involving AMPK and the TSC complex Academic Article
- Mitochondrial clearance is regulated by atg7-dependent and -independent mechanisms during reticulocyte maturation Academic Article
- Modulation of glucokinase by glucose, small-molecule activator and glucokinase regulatory protein: steady-state kinetic and cell-based analysis Academic Article
- Mouse liver repopulation with hepatocytes generated from human fibroblasts Academic Article
- Mouse liver-specific CD8(+) T-cells encounter their cognate antigen and acquire capacity to destroy target hepatocytes Academic Article
- Multi-organ iron overload in an african-american man with alas2 r452s and slc40a1 r561g Academic Article
- Mutation in fucose synthesis gene of Klebsiella pneumoniae affects capsule composition and virulence in mice Academic Article
- N-acylthiadiazolines, a new class of liver x receptor agonists with selectivity for lxr beta Academic Article
- NF-kB inhibition delays DNA damage-induced senescence and aging in mice Academic Article
- New ws9326a congeners from streptomyces sp 9078 inhibiting brugia malayi asparaginyl-trna synthetase Academic Article
- Novel PEI/poly-γ-gutamic acid nanoparticles for high efficient siRNA and plasmid DNA co-delivery Academic Article
- Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1 Academic Article
- Novel endosomolytic poly(amido amine) polymer conjugates for systemic delivery of siRNA to hepatocytes in rodents and nonhuman primates Academic Article
- Peptide inhibitors of hepatitis c virus core oligomerization and virus production Academic Article
- Persistent hepatitis C virus infection in vitro: Coevolution of virus and host Academic Article
- Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection Academic Article
- Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite Academic Article
- Production of infectious hepatitis C virus by well-differentiated, growth-arrested human hepatoma-derived cells Academic Article
- Profiling of MicroRNA Targets Using Activity-Based Protein Profiling: Linking Enzyme Activity to MicroRNA-185 Function Academic Article
- Quantitative inference of cellular parameters from microfluidic cell culture systems Academic Article
- RagA, but not RagB, is essential for embryonic development and adult mice Academic Article
- Real-time monitoring of lactate extrusion and glucose consumption of cultured cells using a lab-on-valve system Academic Article
- Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling Academic Article
- Regulation of carbohydrate metabolism by the farnesoid x receptor Academic Article
- Regulation of hepcidin transcription by interleukin-1 and interleukin-6 Academic Article
- Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin Academic Article
- Regulation of pyruvate dehydrogenase kinase expression by the farnesoid x receptor Academic Article
- Replication of a hepatitis C virus replicon clone in mouse cells Academic Article
- Reprogramming fibroblasts toward cardiomyocytes, neural stem cells and hepatocytes by cell activation and signaling-directed lineage conversion Academic Article
- SERBP1 Is a component of the liver receptor homologue-1 transcriptional complex Academic Article
- Searching for interferon-induced genes that inhibit hepatitis B virus replication in transgenic mouse hepatocytes Academic Article
- Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study Academic Article
- Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity Academic Article
- Simultaneous detection of hepatitis C virus and interferon stimulated gene expression in infected human liver Academic Article
- Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept Academic Article
- Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2 Academic Article
- Stereospecific reduction of a potent kinesin spindle protein (KSP) inhibitor in human tissues Academic Article
- Structure-Activity Relationship and Biological Investigation of SR18292 (16), a Suppressor of Glucagon-Induced Glucose Production Academic Article
- Substituted Pyrazoles as hepatoselective HMG-CoA reductase inhibitors: Discovery of (3R,5R)-7-[2-(4-Fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)- 2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia Academic Article
- Suppression of host p53 is critical for Plasmodium liver-stage infection Academic Article
- Suppression of the hepcidin-encoding gene hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/tmprss6 Academic Article
- Targeted delivery of LXR Agonist Using a site-specific antibody drug conjugate Academic Article
- Temporal orchestration of circadian autophagy rhythm by C/EBPβ Academic Article
- The E3 ubiquitin ligase itch couples JNK activation to TNF alpha-induced cell death by inducing c-FLIP(L) turnover Academic Article
- The contraction phase of virus-specific cd8(+) t cells is unaffected by a pan-caspase inhibitor Academic Article
- The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats Academic Article
- The il-6- and lipopolysaccharide-induced transcription of hepcidin in hfe-, transferrin receptor 2-, and beta(2)-microglobulin-deficient hepatocytes Academic Article
- The isomerase active site of cyclophilin A is critical for hepatitis C virus replication Academic Article
- The pore-forming toxin listeriolysin O mediates a novel entry pathway of L. monocytogenes into human hepatocytes Academic Article
- The size of the viral inoculum contributes to the outcome of hepatitis B virus infection Academic Article
- Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase Academic Article
- Virion-independent transfer of replication-competent hepatitis C virus RNA between permissive cells Academic Article