subject area of
- A high-throughput screening compatible assay for activators and inhibitors of methionine sulfoxide reductase a Academic Article
- Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry Academic Article
- Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth Academic Article
- Allosteric activators of glucokinase: potential role in diabetes therapy Academic Article
- Cefoxitin is both an inhibitor of class A beta-lactamase of Xanthomonas campestris pv. campestris str. 17 and an inducer of its gene Academic Article
- Comparison of the circulating metabolite profile of PF-04991532, a hepatoselective glucokinase activator, across preclinical species and humans: potential implications in metabolites in safety testing assessment Academic Article
- Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A Academic Article
- Design, synthesis and SAR of novel glucokinase activators Academic Article
- Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido )nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus Academic Article
- Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia Academic Article
- Discovery of piragliatin--first glucokinase activator studied in type 2 diabetic patients Academic Article
- Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators Academic Article
- Glucokinase activators Academic Article
- High-throughput FRET assay yields allosteric SERCA activators Academic Article
- Impaired immunoproteasome assembly and immune responses in pa28(-/-) mice Academic Article
- Insight into the rescue of oxidized soluble guanylate cyclase by the activator cinaciguat Academic Article
- Intrinsic electrophilicity of the 4-methylsulfonyl-2-pyridone scaffold in glucokinase activators: Role of glutathione-S-transferases and in vivo quantitation of a glutathione conjugate in rats Academic Article
- Peptides as modulators of enzymes and regulatory proteins Academic Article
- Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif Academic Article
- Single-particle EM reveals the higher-order domain architecture of soluble guanylate cyclase Academic Article
- Small-molecule activators of a proenzyme Academic Article
- Small-molecule procaspase activators identified using fluorescence polarization Academic Article
- Soluble guanylate cyclase is activated differently by excess no and by yc-1: Resonance raman spectroscopic evidence Academic Article
- Strategies for the design of hepatoselective glucokinase activators to treat type 2 diabetes Academic Article
- Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator yc-1 Academic Article
- The design and synthesis of yc-1 analogues as probes for soluble guanylate cyclase Academic Article
- The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats Academic Article