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Enzyme Activators

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  • A high-throughput screening compatible assay for activators and inhibitors of methionine sulfoxide reductase a  Academic Article
  • Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry  Academic Article
  • Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth  Academic Article
  • Allosteric activators of glucokinase: potential role in diabetes therapy  Academic Article
  • Cefoxitin is both an inhibitor of class A beta-lactamase of Xanthomonas campestris pv. campestris str. 17 and an inducer of its gene  Academic Article
  • Comparison of the circulating metabolite profile of PF-04991532, a hepatoselective glucokinase activator, across preclinical species and humans: potential implications in metabolites in safety testing assessment  Academic Article
  • Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A  Academic Article
  • Design, synthesis and SAR of novel glucokinase activators  Academic Article
  • Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido )nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus  Academic Article
  • Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia  Academic Article
  • Discovery of piragliatin--first glucokinase activator studied in type 2 diabetic patients  Academic Article
  • Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators  Academic Article
  • Glucokinase activators  Academic Article
  • High-throughput FRET assay yields allosteric SERCA activators  Academic Article
  • Impaired immunoproteasome assembly and immune responses in pa28(-/-) mice  Academic Article
  • Insight into the rescue of oxidized soluble guanylate cyclase by the activator cinaciguat  Academic Article
  • Intrinsic electrophilicity of the 4-methylsulfonyl-2-pyridone scaffold in glucokinase activators: Role of glutathione-S-transferases and in vivo quantitation of a glutathione conjugate in rats  Academic Article
  • Peptides as modulators of enzymes and regulatory proteins  Academic Article
  • Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif  Academic Article
  • Single-particle EM reveals the higher-order domain architecture of soluble guanylate cyclase  Academic Article
  • Small-molecule activators of a proenzyme  Academic Article
  • Small-molecule procaspase activators identified using fluorescence polarization  Academic Article
  • Soluble guanylate cyclase is activated differently by excess no and by yc-1: Resonance raman spectroscopic evidence  Academic Article
  • Strategies for the design of hepatoselective glucokinase activators to treat type 2 diabetes  Academic Article
  • Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator yc-1  Academic Article
  • The design and synthesis of yc-1 analogues as probes for soluble guanylate cyclase  Academic Article
  • The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats  Academic Article

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