subject area of

• A biosensor-based approach toward purification and crystallization of g protein-coupled receptors  Academic Article
• A conserved hiv gp120 glycoprotein structure involved in chemokine receptor binding  Academic Article
• A double-mimetic peptide efficiently neutralizes HIV-1 by bridging the CD4- and coreceptor-binding sites of gp120  Academic Article
• A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A  Academic Article
• A highly conserved arginine in gp120 governs HIV-1 binding to both syndecans and CCR5 via sulfated motifs  Academic Article
• A low-molecular-weight entry inhibitor of both CCR5- and CXCR4-tropic strains of human immunodeficiency virus type 1 targets a novel site on gp41  Academic Article
• A new perspective on V3 phenotype prediction  Academic Article
• A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5  Academic Article
• A tyrosine-sulfated CCR5-mimetic peptide promotes conformational transitions in the HIV-1 envelope glycoprotein  Academic Article
• A tyrosine-sulfated peptide based on the N terminus of CCR5 interacts with a CD4-enhanced epitope of the HIV-1 gp120 envelope glycoprotein and inhibits HIV-1 entry  Academic Article
• A tyrosine-sulfated peptide derived from the heavy-chain CDR3 region of an HIV-1-neutralizing antibody binds gp120 and inhibits HIV-1 infection  Academic Article
• AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges  Academic Article
• Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gpl120 is sterically restricted on primary human immunodeficiency virus type 1  Academic Article
• Adaptation of a CCR5-using, primary human immunodeficiency virus type 1 isolate for CD4-independent replication  Academic Article
• Adhesion and fusion efficiencies of human immunodeficiency virus type 1 (HIV-1) surface proteins  Academic Article
• Alloantigen-enhanced accumulation of CCR5+ 'effector' regulatory T cells in the gravid uterus  Academic Article
• An aptamer that neutralizes r5 strains of hiv-1 binds to core residues of gp120 in the ccr5 binding site  Academic Article
• An aptamer that neutralizes r5 strains of human immunodeficiency virus type 1 blocks gp120-ccr5 interaction  Academic Article
• Antibody 17b binding at the coreceptor site weakens the kinetics of the interaction of envelope glycoprotein gp120 with cd4  Academic Article
• Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells  Academic Article
• Biology of CCR5 and its role in HIV infection and treatment  Academic Article
• Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface  Academic Article
• Broadly cross-reactive hiv-1-neutralizing human monoclonal fab selected for binding to gp120-cd4-ccr5 complexes  Academic Article
• CCL3L1 and HIV/AIDS susceptibility  Academic Article
• CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia  Academic Article
• CCR5 knockout prevents neuronal injury and behavioral impairment induced in a transgenic mouse model by a CXCR4-using HIV-1 glycoprotein 120  Academic Article
• CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro  Academic Article
• CCR5 mutations distinguish N-terminal modifications of RANTES (CCL5) with agonist versus antagonist activity  Academic Article
• CCR5 promoter polymorphism determines macrophage CCR5 density and magnitude of HIV-1 propagation in vitro  Academic Article
• CD4-independent binding of SIV gp120 to rhesus CCR5  Academic Article
• CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5  Academic Article
• Can gene delivery close the door to HIV-1 entry after escape?  Academic Article
• Ccr5 as a potential target in cancer therapy: Inhibition or stimulation?  Academic Article
• Cell-free human immunodeficiency virus type 1 transcytosis through primary genital epithelial cells  Academic Article
• Cell-penetrating peptide-mediated delivery of TALEN proteins via bioconjugation for genome engineering  Academic Article
• Cell-specific RNA aptamer against human CCR5 specifically targets HIV-1 susceptible cells and inhibits HIV-1 infectivity  Academic Article
• Changes in HIV-1 tropism: clinical and prognostic consequences  Academic Article
• Changes in the V3 region of gp 120 contribute to unusually broad coreceptor usage of an HIV-1 isolate from a CCR5 Delta 32 heterozygote  Academic Article
• Chemokine receptor CCR5 genotype influences the kinetics of human immunodeficiency virus type 1 infection in human PBL-SCID mice  Academic Article
• Chemokine receptors in HIV-1 and SIV infection  Academic Article
• Circulating human CD4 and CD8 T cells do not have large intracellular pools of CCR5  Academic Article
• Clinical applications of genome editing to HIV cure  Academic Article
• Cloning and characterization of functional subtype A HIV-1 envelope variants transmitted through breastfeeding  Academic Article
• Conformational changes of gp120 in epitopes near the ccr5 binding site are induced by cd4 and a cd4 miniprotein mimetic  Academic Article
• Conserved changes in envelope function during human immunodeficiency virus type 1 coreceptor switching  Academic Article
• Current V3 genotyping algorithms are inadequate for predicting X4 co-receptor usage in clinical isolates  Academic Article
• Differential tropism and replication kinetics of human immunodeficiency virus type 1 isolates in thymocytes: coreceptor expression allows viral entry, but productive infection of distinct subsets is determined at the postentry level  Academic Article
• Direct expression and validation of phage-selected peptide variants in mammalian cells  Academic Article
• Disentangling human tolerance and resistance against HIV  Academic Article
• Donor- and ligand-dependent differences in C-C chemokine receptor 5 reexpression  Academic Article
• Dopamine receptor activation increases HIV entry into primary human macrophages  Academic Article
• Enhanced expression, native purification, and characterization of CCR5, a principal HIV-1 coreceptor  Academic Article
• Enhanced recognition and neutralization of HIV-1 by antibody-derived CCR5-mimetic peptide variants  Academic Article
• Evolution of CCR5 use before and during coreceptor switching  Academic Article
• Evolutionary genetics: CCR5 mutation and plague protection  Academic Article
• Extreme genetic divergence is required for coreceptor switching in HIV-1 subtype C  Academic Article
• Fitness epistasis and constraints on adaptation in a human immunodeficiency virus type 1 protein region  Academic Article
• Formation of eosinophilic and monocytic intradermal inflammatory sites in the dog by injection of human rantes but not human monocyte chemoattractant protein-1, human macrophage inflammatory protein 1-alpha, or human interleukin-8  Academic Article
• Functional deletion of the CCR5 receptor by intracellular immunization produces cells that are refractory to CCR5-dependent HIV-1 infection and cell fusion  Academic Article
• Functional mimicry of a human immunodeficiency virus type 1 coreceptor by a neutralizing monoclonal antibody  Academic Article
• Generation and characterization of a recombinant human CCR5-specific antibody. A phage display approach for rabbit antibody humanization  Academic Article
• Genetic and phenotypic analyses of human immunodeficiency virus type 1 escape from a small-molecule ccr5 inhibitor  Academic Article
• Gp120: Biologic aspects of structural features  Academic Article
• HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells  Academic Article
• HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection  Academic Article
• HIV-1 entry and macrophage inflammatory protein-1 beta-mediated signaling are independent functions of the chemokine receptor CCR5  Academic Article
• HIV-1 subtype A envelope variants from early in infection have variable sensitivity to neutralization and to inhibitors of viral entry  Academic Article
• Highly potent RANTES analogues either prevent CCR5-using human immunodeficiency virus type 1 infection in vivo or rapidly select for CXCR4-using variants  Academic Article
• Highly potent, fully recombinant anti-HIV chemokines: reengineering a low-cost microbicide  Academic Article
• Highly stable trimers formed by human immunodeficiency virus type 1 envelope glycoproteins fused with the trimeric motif of T4 bacteriophage fibritin  Academic Article
• Host and viral genetic correlates of clinical definitions of HIV-1 disease progression  Academic Article
• How HIV changes its tropism: evolution and adaptation?  Academic Article
• Human adipose cells express CD4, CXCR4, and CCR5 receptors: a new target cell type for the immunodeficiency virus-1  Academic Article
• Human immunodeficiency virus type 1 coreceptor switching: V1/V2 gain-of-fitness mutations compensate for V3 loss-of-fitness mutations  Academic Article
• Human mast cell progenitors can be infected by macrophagetropic human immunodeficiency virus type 1 and retain virus with maturation in vitro  Academic Article
• ICOS controls effector function but not trafficking receptor expression of kidney-infiltrating effector T cells in murine lupus  Academic Article
• Identifying safety concerns from genetic data: lessons from the development of CCR5 inhibitors  Academic Article
• Increased CCR5 affinity and reduced CCR5/CD4 dependence of a neurovirulent primary human immunodeficiency virus type 1 isolate  Academic Article
• Induction, characterization, and functional coupling of the high affinity chemokine receptor for RANTES and macrophage inflammatory protein-1 alpha upon differentiation of an eosinophilic HL-60 cell line  Academic Article
• Inhibition of HIV ENV binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged gp120  Academic Article
• Intrinsic obstacles to human immunodeficiency virus type 1 coreceptor switching  Academic Article
• Mechanisms of neuronal injury and death in HIV-1 associated dementia  Academic Article
• Medicinal chemistry applied to a synthetic protein: development of highly potent HIV entry inhibitors  Academic Article
• Mode of action for linear peptide inhibitors of hiv-1 gp120 interactions  Academic Article
• Modifications that stabilize human immunodeficiency virus envelope glycoprotein trimers in solution  Academic Article
• Multiple antiviral activities of cyanovirin-n: Blocking of human immunodeficiency virus type 1 gp120 interaction with cd4 and coreceptor and inhibition of diverse enveloped viruses  Academic Article
• Mutagenic stabilization and/or disruption of a cd4-bound state reveals distinct conformations of the human immunodeficiency virus type 1 gp120 envelope glycoprotein  Academic Article
• N-linked glycosylation in the CXCR4 N-tenninus inhibits binding to HIV-1 envelope glycoproteins  Academic Article
• One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the blt model for evaluation of new microbicide candidates  Academic Article
• Paramagnetic proteoliposomes containing a pure, native, and oriented seven-transmembrane segment protein, CCR5  Academic Article
• Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load  Academic Article
• Potent inhibition of hiv-1 entry with a chemically programmed antibody aided by an efficient organocatalytic synthesis  Academic Article
• Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5  Academic Article
• Production of the chemokine RANTES by articular chondrocytes and role in cartilage degradation  Academic Article
• Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infections  Academic Article
• Redesigning recombinase specificity for safe harbor sites in the human genome  Academic Article
• Redox-triggered infection by disulfide-shackled human immunodeficiency virus type 1 pseudovirions  Academic Article
• Resistance to the CCR5 inhibitor 5P12-RANTES requires a difficult evolution from CCR5 to CXCR4 coreceptor use  Academic Article
• Safety concerns about CCR5 as an antiviral target  Academic Article
• Sialylated O-glycans and sulfated tyrosines in the NH2-terminal domain of CC chemokine receptor 5 contribute to high affinity binding of chemokines  Academic Article
• Structure of a v3-containing hiv-1 gp120 core  Academic Article
• Structure of an hiv gp120 envelope glycoprotein in complex with the cd4 receptor and a neutralizing human antibody  Academic Article
• Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex  Academic Article
• Structure-based stabilization of hiv-1 gp120 enhances humoral immune responses to the induced co-receptor binding site  Academic Article
• Structures of the ccr5 n terminus and of a tyrosine-sulfated antibody with hiv-1 gp120 and cd4  Academic Article
• T-cell protection and enrichment through lentiviral CCR5 intrabody gene delivery  Academic Article
• Targeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzyme  Academic Article
• Targeted gene knockout by direct delivery of zinc-finger nuclease proteins  Academic Article
• Targeting the HIV-1 spike and coreceptor with bi- and trispecific antibodies for single-component broad inhibition of entry  Academic Article
• The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates  Academic Article
• The bis-azo compound FP-21399 inhibits HIV-1 replication by preventing viral entry  Academic Article
• The ccr5 receptor acts as an alloantigen in ccr5 delta 32 homozygous individuals: Identification of chemokine- and hiv-1-blocking human antibodies  Academic Article
• The clinical applications of genome editing in HIV  Academic Article
• The orphan seven-transmembrane receptor apj supports the entry of primary T-cell-line-tropic and dualtropic human immunodeficiency virus type 1  Academic Article
• Transcription factor GATA-1 potently represses the expression of the HIV-1 coreceptor CCR5 in human T cells and dendritic cells  Academic Article
• Two mechanisms for human immunodeficiency virus type 1 inhibition by N-terminal modifications of RANTES  Academic Article
• Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection  Academic Article
• Tyrosine sulfation of HIV-1 coreceptors and other chemokine receptors  Academic Article
• Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120  Academic Article
• Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry  Academic Article
• Tyrosine-sulfate isosteres of ccr5 n-terminus as tools for studying hiv-1 entry  Academic Article
• Tyrosine-sulfated peptides functionally reconstitute a CCR5 variant lacking a critical amino-terminal region  Academic Article
• Utilization of C-C chemokine receptor 5 by the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIV(mac)239  Academic Article