subject area of

• A bifunctional molecule that displays context-dependent cellular activity  Academic Article
• A cross-strand Trp-Trp pair stabilizes the hPin1 WW domain at the expense of function  Academic Article
• A reduced-amide inhibitor of Pin1 binds in a conformation resembling a twisted-amide transition state  Academic Article
• An analysis of the expression of cyclophilin-c reveals tissue restriction and an intriguing pattern in the mouse kidney  Academic Article
• An endoplasmic reticulum-specific cyclophilin  Academic Article
• Calcineurin is a common target of cyclophilin-cyclosporine-a and fkbp-fk506 complexes  Academic Article
• Chain dynamics of nascent polypeptides emerging from the ribosome  Academic Article
• Characterization of native protein complexes using ultraviolet photodissociation mass spectrometry  Academic Article
• Chemical tools for studying the impact of cis/trans prolyl isomerization on signaling: a case study on RNA polymerase II phosphatase activity and specificity  Academic Article
• Complete protein characterization using top-down mass spectrometry and ultraviolet photodissociation  Academic Article
• Conformational polymorphism of cyclosporine-a  Academic Article
• Context-dependent contributions of backbone hydrogen bonding to β-sheet folding energetics  Academic Article
• Cooperation between different cdc4/fbw7 isoforms may be associated with 2-step inactivation of scfcdc4 targets  Academic Article
• Crystal structure of TM1367 from Thermotoga maritima at 1.90 Å resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold  Academic Article
• Crystal structure of the complex of brugia malayi cyclophilin and cyclosporin a  Academic Article
• Cyclophilin inhibitors for the treatment of HCV infection  Academic Article
• Cyclophilin-A is bound through its peptidylprolyl isomerase domain to the cytoplasmic dynein motor protein complex  Academic Article
• Cyclosporine-a - cyclophilin complex-formation - a model based on x-ray and NMR data  Academic Article
• Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function  Academic Article
• Destabilization of the complete protein secondary structure on binding to the chaperone groel  Academic Article
• Determination of the NMR solution structure of the cyclophilin-a - cyclosporine-a complex  Academic Article
• ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect  Academic Article
• Engineering a beta-sheet protein toward the folding speed limit  Academic Article
• Evaluating beta-turn mimics as beta-sheet folding nucleators  Academic Article
• Fbw7alpha and fbw7gamma collaborate to shuttle cyclin e1 into the nucleolus for multiubiquitylation  Academic Article
• High-resolution mapping of the folding transition state of a WW domain  Academic Article
• Host cyclophilin A mediates HIV-1 attachment to target cells via heparans  Academic Article
• Human immunodeficiency virus type 1 hijacks host cyclophilin A for its attachment to target cells  Academic Article
• Identification of inhibitors of the E. coli chaperone SurA using in silico and in vitro techniques  Academic Article
• Increasing protein stability using a rational approach combining sequence homology and structural alignment: stabilizing the WW domain  Academic Article
• Influence of hPin1 WWN-terminal domain boundaries on function, protein stability, and folding  Academic Article
• Inhibition of calcineurin by a novel fk-506-binding protein  Academic Article
• Multiple cycles of global unfolding of groel-bound cyclophilin a evidenced by NMR  Academic Article
• N-PEGylation of a reverse turn is stabilizing in multiple sequence contexts, unlike N-GlcNAcylation  Academic Article
• NMR solution structure of the isolated Apo Pin1 WW domain: comparison to the X-ray crystal structures of Pin1  Academic Article
• Nucleotide-sequence of a cdna coding for mouse cyclophilin  Academic Article
• Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease  Academic Article
• Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turns  Academic Article
• Sequence determinants of thermodynamic stability in a ww domain. An all-beta-sheet protein  Academic Article
• Structural and kinetic analysis of prolyl-isomerization/phosphorylation cross-talk in the CTD code  Academic Article
• Structural basis for high-affinity peptide inhibition of human Pin1  Academic Article
• Structure discrimination for the c-terminal domain of escherichia coli trigger factor in solution  Academic Article
• Structure of human cyclophilin and its binding-site for cyclosporine-a determined by x-ray crystallography and NMR-spectroscopy  Academic Article
• Structure-function-folding relationship in a WW domain  Academic Article
• Synthesis of a negatively charged dibenzofuran-based beta-turn mimetic and its incorporation into the WW miniprotein-enhanced solubility without a loss of thermodynamic stability  Academic Article
• The NMR solution conformation of unligated human cyclophilin A  Academic Article
• The NMR structure of cyclosporine-a bound to cyclophilin in aqueous-solution  Academic Article
• The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus  Academic Article
• The effect of backbone cyclization on the thermodynamics of beta-sheet unfolding: Stability optimization of the PINWW domain  Academic Article
• Three-dimensional structure and actions of immunosuppressants and their immunophilins  Academic Article
• Toward assessing the position-dependent contributions of backbone hydrogen bonding to β-sheet folding thermodynamics employing amide-to-ester perturbations  Academic Article
• Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: one in the presence and one in the absence of CsA  Academic Article
• Ubiquitylation of cyclin e requires the sequential function of scf complexes containing distinct hcdc4 isoforms  Academic Article
• p1B15: a cDNA clone of the rat mRNA encoding cyclophilin  Academic Article