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HIV Integrase

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  • A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase  Academic Article
  • A dynamic model of HIV integrase inhibition and drug resistance  Academic Article
  • Active site binding modes of curcumin in HIV-1 protease and integrase  Academic Article
  • Blind prediction of HIV integrase binding from the SAMPL4 challenge  Academic Article
  • Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome  Academic Article
  • Discovery of a distinct chemical and mechanistic class of allosteric HIV-1 integrase inhibitors with antiretroviral activity  Academic Article
  • Dithiothreitol causes HIV-1 integrase dimer dissociation while agents interacting with the integrase dimer interface promote dimer formation  Academic Article
  • First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G  Academic Article
  • Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein e2c direct integration of viral DNA into specific sites  Academic Article
  • Human immunodeficiency virus type 1 incorporated with fusion proteins consisting of integrase and the designed polydactyl zinc finger protein e2c can bias integration of viral DNA into a predetermined chromosomal region in human cells  Academic Article
  • Identification of efficiently cleaved substrates for HIV-1 protease using a phage display library and use in inhibitor development  Academic Article
  • New class of HIV-1 integrase (IN) inhibitors with a dual mode of action  Academic Article
  • Recombinant rabbit single-chain antibodies bind to the catalytic and c-terminal domains of hiv-1 integrase protein and strongly inhibit hiv-1 replication  Academic Article
  • Single-particle image reconstruction of a tetramer of hiv integrase bound to DNA  Academic Article
  • Structural basis for strand-transfer inhibitor binding to HIV intasomes  Academic Article
  • The food of sweet and bitter fancy  Academic Article
  • The integrase interactor I (INII) proteins facilitate Tat-mediated human immunodeficiency virus type I transcription  Academic Article
  • Virtual screening of integrase inhibitors by large scale binding free energy calculations: the SAMPL4 challenge  Academic Article
  • Virtual screening with AutoDock Vina and the common pharmacophore engine of a low diversity library of fragments and hits against the three allosteric sites of HIV integrase: participation in the SAMPL4 protein-ligand binding challenge  Academic Article

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